RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119619194 222 SLNPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLL 301
Cdd:cd04376    1 SLNPIARQVPRLVESCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDENHSVHDVAALLKEFFRDMPDPLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119619194 302 TRELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNISKDGQEVTGNKMTSLNLATIFGPN 381
Cdd:cd04376   81 PRELYTAFIGTALLEPDEQLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADSIDEDGQEVSGNKMTSLNLATIFGPN 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 119619194 382 LLHKQKSSDKEFsVQSSARAEESTAIIAVVQKMIENYEALFMVPPDL 428
Cdd:cd04376  161 LLHKQKSGEREF-VQASLRIEESTAIINVVQTMIDNYEELFMVSPEL 206

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119619194 222 SLNPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLL 301
Cdd:cd04376    1 SLNPIARQVPRLVESCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDENHSVHDVAALLKEFFRDMPDPLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119619194 302 TRELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNISKDGQEVTGNKMTSLNLATIFGPN 381
Cdd:cd04376   81 PRELYTAFIGTALLEPDEQLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADSIDEDGQEVSGNKMTSLNLATIFGPN 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 119619194 382 LLHKQKSSDKEFsVQSSARAEESTAIIAVVQKMIENYEALFMVPPDL 428
Cdd:cd04376  161 LLHKQKSGEREF-VQASLRIEESTAIINVVQTMIDNYEELFMVSPEL 206

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119619194  231 PRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLE-EEHSVHDVAALLKEFLRDMPDPLLTRELYTAF 309
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPDVDLDlEEEDVHVVASLLKLFLRELPEPLLTFELYEEF 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 119619194  310 INTLLLE-PEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGPNLLH 384
Cdd:pfam00620  81 IEAAKLPdEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDV-----------NKMNAHNLAIVFGPTLLR 145

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119619194 222 SLNPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLL 301
Cdd:cd04376    1 SLNPIARQVPRLVESCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDENHSVHDVAALLKEFFRDMPDPLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119619194 302 TRELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNISKDGQEVTGNKMTSLNLATIFGPN 381
Cdd:cd04376   81 PRELYTAFIGTALLEPDEQLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADSIDEDGQEVSGNKMTSLNLATIFGPN 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 119619194 382 LLHKQKSSDKEFsVQSSARAEESTAIIAVVQKMIENYEALFMVPPDL 428
Cdd:cd04376  161 LLHKQKSGEREF-VQASLRIEESTAIINVVQTMIDNYEELFMVSPEL 206

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119619194  231 PRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLE-EEHSVHDVAALLKEFLRDMPDPLLTRELYTAF 309
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPDVDLDlEEEDVHVVASLLKLFLRELPEPLLTFELYEEF 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 119619194  310 INTLLLE-PEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGPNLLH 384
Cdd:pfam00620  81 IEAAKLPdEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDV-----------NKMNAHNLAIVFGPTLLR 145

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119619194 230 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDR--GIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYT 307
Cdd:cd04391   22 VPLIFQKLINKLEERGLETEGILRIPGSAQRVKFLCQELEAkfYEGTFLWDQVKQHDAASLLKLFIRELPQPLLTVEYLP 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119619194 308 AFINTLLL-EPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGPNLL--H 384
Cdd:cd04391  102 AFYSVQGLpSKKDQLQALNLLVLLLPEANRDTLKALLEFLQKVVDHEEK-----------NKMNLWNVAMIMAPNLFppR 170

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 119619194 385 KQKSSDKEfSVQSSARAEESTAIIavVQKMIENYEALFMVPPDLQNEV 432
Cdd:cd04391  171 GKHSKDNE-SLQEEVNMAAGCANI--MRLLIRYQDLLWTVPSFLINQV 215

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119619194 230 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRG---IDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELY 306
Cdd:cd04395   18 VPLIVEVCCNIVEARGLETVGIYRVPGNNAAISALQEELNRGgfdIDLQDPRWRDVNVVSSLLKSFFRKLPEPLFTNELY 97

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 119619194 307 TAFINTLLLE-PEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGPNL 382
Cdd:cd04395   98 PDFIEANRIEdPVERLKELRRLIHSLPDHHYETLKHLIRHLKTVADNSEV-----------NKMEPRNLAIVFGPTL 163

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119619194 224 NPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTR 303
Cdd:cd04404   17 NPEQEPIPPVVRETVEYLQAHALTTEGIFRRSANTQVVKEVQQKYNMGEPVDFDQYEDVHLPAVILKTFLRELPEPLLTF 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119619194 304 ELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGPNLL 383
Cdd:cd04404   97 DLYDDIVGFLNVDKEERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQ-----------NKMTNSNLAVVFGPNLL 165

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 119619194 384 HKQKssdkefsvqSSARAEESTAIIAVVQKMIENYEALF 422
Cdd:cd04404  166 WAKD---------ASMSLSAINPINTFTKFLLDHQDEIF 195

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119619194 228 RQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYT 307
Cdd:cd04377   13 RSVPLVLEKLLEHIEMHGLYTEGIYRKSGSANKIKELRQGLDTDPDSVNLEDYPIHVITSVLKQWLRELPEPLMTFELYE 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119619194 308 AFINTL-LLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGPNLLHKQ 386
Cdd:cd04377   93 NFLRAMeLEEKQERVRALYSVLEQLPRANLNTLERLIFHLVRVALQEEV-----------NRMSANALAIVFAPCILRCP 161

                        170
                 ....*....|....
gi 119619194 387 KSSDKEFSVQSSAR 400
Cdd:cd04377  162 DTADPLQSLQDVSK 175

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119619194 230 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYTAF 309
Cdd:cd04393   20 VPAVVRHIVEYLEQHGLEQEGLFRVNGNAETVEWLRQRLDSGEEVDLSKEADVCSAASLLRLFLQELPEGLIPASLQIRL 99

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 119619194 310 INTL--LLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNIskdgqevtgnkMTSLNLATIFGPNLLH 384
Cdd:cd04393  100 MQLYqdYNGEDEFGRKLRDLLQQLPPVNYSLLKFLCHFLSNVASQHHENR-----------MTAENLAAVFGPDVFH 165

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119619194 228 RQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRG-IDVSLEEEHS-VHDVAALLKEFLRDMPDPLLTREL 305
Cdd:cd04386   18 REIALPIEACVMCLLETGMNEEGLFRVGGGASKLKRLKAALDAGtFSLPLDEFYSdPHAVASALKSYLRELPDPLLTYNL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119619194 306 YTAFINTLLLE-PEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGPNLLh 384
Cdd:cd04386   98 YEDWVQAANKPdEDERLQAIWRILNKLPRENRDNLRYLIKFLSKLAQKSDE-----------NKMSPSNIAIVLAPNLL- 165

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 119619194 385 kqksSDKEFSVQSSARAEESTAIIAVVQKMIENYEALF 422
Cdd:cd04386  166 ----WAKNEGSLAEMAAGTSVHVVAIVELIISHADWFF 199

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119619194 230 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLR--EEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYT 307
Cdd:cd04403   16 VPKFVRLCIEAVEKRGLDVDGIYRVSGNLAVIQKLRfaVDHDEKLDLDDSKWEDIHVITGALKLFFRELPEPLFPYSLFN 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119619194 308 AFINTLLL-EPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGPNLLHKQ 386
Cdd:cd04403   96 DFVAAIKLsDYEQRVSAVKDLIKSLPKPNHDTLKMLFRHLCRVIEHGEK-----------NRMTTQNLAIVFGPTLLRPE 164

                 ...
gi 119619194 387 KSS 389
Cdd:cd04403  165 QET 167

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119619194 226 IYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDV--SLEEE-HSVHDVAALLKEFLRDMPDPLLT 302
Cdd:cd04396   28 VYGYIPVVVAKCGVYLKENATEVEGIFRVAGSSKRIRELQLIFSTPPDYgkSFDWDgYTVHDAASVLRRYLNNLPEPLVP 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119619194 303 RELYTAFINTLLLEP------------------EEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNIskdgqev 364
Cdd:cd04396  108 LDLYEEFRNPLRKRPrilqymkgrineplntdiDQAIKEYRDLITRLPNLNRQLLLYLLDLLAVFARNSDKNL------- 180

                        170
                 ....*....|....*....
gi 119619194 365 tgnkMTSLNLATIFGPNLL 383
Cdd:cd04396  181 ----MTASNLAAIFQPGIL 195

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119619194 230 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYTAF 309
Cdd:cd04378   16 VPFIIKKCTSEIENRALGVQGIYRVSGSKARVEKLCQAFENGKDLVELSELSPHDISSVLKLFLRQLPEPLILFRLYNDF 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119619194 310 I---NTLLLEPEEQLG------------TLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNL 374
Cdd:cd04378   96 IalaKEIQRDTEEDKApntpievnriirKLKDLLRQLPASNYNTLQHLIAHLYRVAEQFEE-----------NKMSPNNL 164

                        170       180
                 ....*....|....*....|...
gi 119619194 375 ATIFGPNLLhKQKSSDKEFSVQS 397
Cdd:cd04378  165 GIVFGPTLI-RPRPGDADVSLSS 186

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119619194 230 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYTAF 309
Cdd:cd04382   17 IPALIVHCVNEIEARGLTEEGLYRVSGSEREVKALKEKFLRGKTVPNLSKVDIHVICGCLKDFLRSLKEPLITFALWKEF 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119619194 310 IN-TLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARhaddniSKDgqevtgNKMTSLNLATIFGPNLL-HKQK 387
Cdd:cd04382   97 MEaAEILDEDNSRAALYQAISELPQPNRDTLAFLILHLQRVAQ------SPE------CKMDINNLARVFGPTIVgYSVP 164

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 119619194 388 SSDKEFSVQssaraeestaiIAVVQKMIenYEALFMVPPD 427
Cdd:cd04382  165 NPDPMTILQ-----------DTVRQPRV--VERLLEIPSD 191

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119619194 241 LEKHgLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEE-EHSVHDVAALLKEFLRDMPDPLLTRELYTAFI--------- 310
Cdd:cd04392   20 LEKN-LRVEGLFRKPGNSARQQELRDLLNSGTDLDLESgGFHAHDCATVLKGFLGELPEPLLTHAHYPAHLqiadlcqfd 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119619194 311 ----NTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGPNLLHKQ 386
Cdd:cd04392   99 ekgnKTSAPDKERLLEALQLLLLLLPEENRNLLKLILDLLYQTAKHEDK-----------NKMSADNLALLFTPHLICPR 167

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 119619194 387 KssdkefsVQSSARAEESTAIIAVVQKMIENYEALFMVPPDLQNEV 432
Cdd:cd04392  168 N-------LTPEDLHENAQKLNSIVTFMIKHSQKLFKAPAYLREDA 206

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119619194 230 VPRLVDSCCQHLEKHGLQTvGIFRVGSSKKRVRQLREEFDRGIDVSLEEE---HSVHDVAALLKEFLRDMPDPLLTRELY 306
Cdd:cd04384   18 VPQVLKSCTEFIEKHGIVD-GIYRLSGIASNIQRLRHEFDSEQIPDLTKDvyiQDIHSVSSLCKLYFRELPNPLLTYQLY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119619194 307 TAFINTLLLEP-EEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHaddniskdgQEVTGnkMTSLNLATIFGPNLLHK 385
Cdd:cd04384   97 EKFSEAVSAASdEERLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKY---------CSITN--MHAKNLAIVWAPNLLRS 165

                 ....*....
gi 119619194 386 QKSSDKEFS 394
Cdd:cd04384  166 KQIESACFS 174

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119619194 228 RQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDR---GIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRE 304
Cdd:cd04379   16 RDVPIVLQKCVQEIERRGLDVIGLYRLCGSAAKKKELRDAFERnsaAVELSEELYPDINVITGVLKDYLRELPEPLITPQ 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119619194 305 LYTAFINTLLLEPE---EQLGTLQL-LIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGP 380
Cdd:cd04379   96 LYEMVLEALAVALPndvQTNTHLTLsIIDCLPLSAKATLLLLLDHLSLVLSNSER-----------NKMTPQNLAVCFGP 164

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 119619194 381 NLL-HKQKSSDKEFSVQSSARAEESTAI---IAVVQKMIE 416
Cdd:cd04379  165 VLMfCSQEFSRYGISPTSKMAAVSTVDFkqhIEVLHYLLQ 204

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119619194 229 QVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEeHSVHDVAALLKEFLRDMPDPLLTRELYTA 308
Cdd:cd04381   19 DLPLVFRECIDYVEKHGMKCEGIYKVSGIKSKVDELKAAYNRRESPNLEE-YEPPTVASLLKQYLRELPEPLLTKELMPR 97

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 119619194 309 FINTLLLEPE-EQLGTLQLLIYLLPPCNcdtlhRLLqfLSIVARHADDNISKDGQevtgNKMTSLNLATIFGPNL 382
Cdd:cd04381   98 FEEACGRPTEaEREQELQRLLKELPECN-----RLL--LAWLIVHMDHVIAQELE----TKMNIQNISIVLSPTV 161

RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr kinase domain, an N-terminal oligomerization domain, and a C-terminal PDZ binding domain, in addition to PH and C2 domains. Bcr is a negative regulator of: i) RacGTPase, via the Rho GAP domain, ii) the Ras-Raf-MEK-ERK pathway, via phosphorylation of the Ras binding protein AF-6, and iii) the Wnt signaling pathway through binding beta-catenin. Bcr can form a complex with beta-catenin and Tcf1. The Wnt signaling pathway is involved in cell proliferation, differentiation, and cell renewal. Bcr was discovered as a fusion partner of Abl. The Bcr-Abl fusion is characteristic for a large majority of chronic myelogenous leukemias (CML). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.