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Conserved domains on  [gi|119628031|gb|EAX07626|]
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WD repeat domain 57 (U5 snRNP specific), isoform CRA_a [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
19-351 5.77e-82

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 255.22  E-value: 5.77e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031  19 RQRHELLLGAGSGPGAGQQQATPGALLQAGPPRCSSlQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVY-G 97
Cdd:COG2319   74 LLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT-GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAtG 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031  98 DCdnYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVcTGSDDGTVK 177
Cdd:COG2319  153 KL--LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLA-SGSADGTVR 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031 178 LWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMD 256
Cdd:COG2319  230 LWDLATGKLLRTLTgHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDD 309

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031 257 NTVRVWDVRpfapKERCVKIFQGNVHNfeknLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFH 336
Cdd:COG2319  310 GTVRLWDLA----TGKLLRTLTGHTGA----VRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFS 381

                        330
                 ....*....|....*
gi 119628031 337 PDEPIIISASSDKRL 351
Cdd:COG2319  382 PDGRTLASGSADGTV 396
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
19-351 5.77e-82

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 255.22  E-value: 5.77e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031  19 RQRHELLLGAGSGPGAGQQQATPGALLQAGPPRCSSlQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVY-G 97
Cdd:COG2319   74 LLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT-GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAtG 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031  98 DCdnYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVcTGSDDGTVK 177
Cdd:COG2319  153 KL--LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLA-SGSADGTVR 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031 178 LWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMD 256
Cdd:COG2319  230 LWDLATGKLLRTLTgHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDD 309

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031 257 NTVRVWDVRpfapKERCVKIFQGNVHNfeknLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFH 336
Cdd:COG2319  310 GTVRLWDLA----TGKLLRTLTGHTGA----VRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFS 381

                        330
                 ....*....|....*
gi 119628031 337 PDEPIIISASSDKRL 351
Cdd:COG2319  382 PDGRTLASGSADGTV 396
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 62-351 7.67e-80

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 245.71  E-value: 7.67e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031  62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDcDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETG 141
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG-ELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031 142 ERVKRLKGHTSFVNSC--YPARRgpqLVCTGSDDGTVKLWDIRKKAAIQTFQN-TYQVLAVTFNDTSDQIISGGIDNDIK 218
Cdd:cd00200   84 ECVRTLTGHTSYVSSVafSPDGR---ILSSSSRDKTIKVWDVETGKCLTTLRGhTDWVNSVAFSPDGTFVASSSQDGTIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031 219 VWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRpfapKERCVKIFQGnvhnFEKNLLRCSWSPDGS 298
Cdd:cd00200  161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS----TGKCLGTLRG----HENGVNSVAFSPDGY 232

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 119628031 299 KIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRL 351
Cdd:cd00200  233 LLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTI 285
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 122-312 1.14e-19

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 90.53  E-value: 1.14e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031 122 SMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTF 201
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQF 625

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031 202 -NDTSDQIISGGIDNDIKVWDLRQNKLTY-TMRGHADSVTGLSLsSEGSYLLSNAMDNTVRVWDVRPFAP--KERCVKIF 277
Cdd:PLN00181 626 pSESGRSLAFGSADHKVYYYDLRNPKLPLcTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWDLSMSISgiNETPLHSF 704

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 119628031 278 QGnvHNFEKNLLRCSWSpDGSkIAAGSADRFVYVW 312
Cdd:PLN00181 705 MG--HTNVKNFVGLSVS-DGY-IATGSETNEVFVY 735
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 58-94 1.33e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.00  E-value: 1.33e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 119628031    58 PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWN 94
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
58-94 9.53e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.73  E-value: 9.53e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 119628031   58 PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWN 94
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
19-351 5.77e-82

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 255.22  E-value: 5.77e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031  19 RQRHELLLGAGSGPGAGQQQATPGALLQAGPPRCSSlQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVY-G 97
Cdd:COG2319   74 LLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT-GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAtG 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031  98 DCdnYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVcTGSDDGTVK 177
Cdd:COG2319  153 KL--LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLA-SGSADGTVR 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031 178 LWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMD 256
Cdd:COG2319  230 LWDLATGKLLRTLTgHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDD 309

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031 257 NTVRVWDVRpfapKERCVKIFQGNVHNfeknLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFH 336
Cdd:COG2319  310 GTVRLWDLA----TGKLLRTLTGHTGA----VRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFS 381

                        330
                 ....*....|....*
gi 119628031 337 PDEPIIISASSDKRL 351
Cdd:COG2319  382 PDGRTLASGSADGTV 396
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 62-351 7.67e-80

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 245.71  E-value: 7.67e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031  62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDcDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETG 141
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG-ELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031 142 ERVKRLKGHTSFVNSC--YPARRgpqLVCTGSDDGTVKLWDIRKKAAIQTFQN-TYQVLAVTFNDTSDQIISGGIDNDIK 218
Cdd:cd00200   84 ECVRTLTGHTSYVSSVafSPDGR---ILSSSSRDKTIKVWDVETGKCLTTLRGhTDWVNSVAFSPDGTFVASSSQDGTIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031 219 VWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRpfapKERCVKIFQGnvhnFEKNLLRCSWSPDGS 298
Cdd:cd00200  161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS----TGKCLGTLRG----HENGVNSVAFSPDGY 232

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 119628031 299 KIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRL 351
Cdd:cd00200  233 LLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
19-352 1.41e-74

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 235.96  E-value: 1.41e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031  19 RQRHELLLGAGSGPGAGQQQATPGALLQAGPPRCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGD 98
Cdd:COG2319   31 LLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATG 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031  99 cDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVcTGSDDGTVKL 178
Cdd:COG2319  111 -LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLA-SGSDDGTVRL 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031 179 WDIRKKAAIQTFQN-TYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDN 257
Cdd:COG2319  189 WDLATGKLLRTLTGhTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADG 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031 258 TVRVWDVRPfapkERCVKIFQGNVHNfeknLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHP 337
Cdd:COG2319  269 TVRLWDLAT----GELLRTLTGHSGG----VNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP 340

                        330
                 ....*....|....*
gi 119628031 338 DEPIIISASSDKRLY 352
Cdd:COG2319  341 DGKTLASGSDDGTVR 355
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 101-352 2.28e-67

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 213.74  E-value: 2.28e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031 101 NYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCtGSDDGTVKLWD 180
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLAS-GSSDKTIRLWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031 181 IRKKAAIQTFQN-TYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTV 259
Cdd:cd00200   80 LETGECVRTLTGhTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031 260 RVWDVRPFapkeRCVKIFQGnvHnfEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDE 339
Cdd:cd00200  160 KLWDLRTG----KCVATLTG--H--TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG 231

                        250
                 ....*....|...
gi 119628031 340 PIIISASSDKRLY 352
Cdd:cd00200  232 YLLASGSEDGTIR 244
WD40 COG2319
WD40 repeat [General function prediction only];
62-316 4.04e-67

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 216.70  E-value: 4.04e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031  62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVY-GDCdnYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSET 140
Cdd:COG2319  158 LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAtGKL--LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT 235

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031 141 GERVKRLKGHTSFVNSCYPARRGPQLVcTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKV 219
Cdd:COG2319  236 GKLLRTLTGHSGSVRSVAFSPDGRLLA-SGSADGTVRLWDLATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRL 314

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031 220 WDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRpfapKERCVKIFQGnvHnfEKNLLRCSWSPDGSK 299
Cdd:COG2319  315 WDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA----TGELLRTLTG--H--TGAVTSVAFSPDGRT 386

                        250
                 ....*....|....*..
gi 119628031 300 IAAGSADRFVYVWDTTS 316
Cdd:COG2319  387 LASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 62-313 8.14e-67

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 212.58  E-value: 8.14e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031  62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYaTLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETG 141
Cdd:cd00200   47 LKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR-TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031 142 ERVKRLKGHTSFVNSCyPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVW 220
Cdd:cd00200  126 KCLTTLRGHTDWVNSV-AFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTgHTGEVNSVAFSPDGEKLLSSSSDGTIKLW 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031 221 DLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRpfapKERCVKIFQGnvHnfEKNLLRCSWSPDGSKI 300
Cdd:cd00200  205 DLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLR----TGECVQTLSG--H--TNSVTSLAWSPDGKRL 276

                        250
                 ....*....|...
gi 119628031 301 AAGSADRFVYVWD 313
Cdd:cd00200  277 ASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
74-351 4.34e-54

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 182.80  E-value: 4.34e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031  74 FHPNGSTLASAGFDRLILLWNVYGDcDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSF 153
Cdd:COG2319    2 LSADGAALAAASADLALALLAAALG-ALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031 154 VNSCYPARRGPQLVcTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMR 232
Cdd:COG2319   81 VLSVAFSPDGRLLA-SASADGTVRLWDLATGLLLRTLTgHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031 233 GHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRpfapKERCVKIFQGnvHNFEknLLRCSWSPDGSKIAAGSADRFVYVW 312
Cdd:COG2319  160 GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA----TGKLLRTLTG--HTGA--VRSVAFSPDGKLLASGSADGTVRLW 231

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 119628031 313 DTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRL 351
Cdd:COG2319  232 DLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 58-263 7.63e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 139.78  E-value: 7.63e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031  58 PIMLLSGHEGEVYCCKFHPngstlasagfdrlillwnvygdcdnyatlkghsgavmelhyntDGSMLFSASTDKTVAVWD 137
Cdd:cd00200  127 CLTTLRGHTDWVNSVAFSP-------------------------------------------DGTFVASSSQDGTIKLWD 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031 138 SETGERVKRLKGHTSFVNSCYPARRGPQLvCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDND 216
Cdd:cd00200  164 LRTGKCVATLTGHTGEVNSVAFSPDGEKL-LSSSSDGTIKLWDLSTGKCLGTLRgHENGVNSVAFSPDGYLLASGSEDGT 242

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 119628031 217 IKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWD 263
Cdd:cd00200  243 IRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 122-312 1.14e-19

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 90.53  E-value: 1.14e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031 122 SMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTF 201
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQF 625

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031 202 -NDTSDQIISGGIDNDIKVWDLRQNKLTY-TMRGHADSVTGLSLsSEGSYLLSNAMDNTVRVWDVRPFAP--KERCVKIF 277
Cdd:PLN00181 626 pSESGRSLAFGSADHKVYYYDLRNPKLPLcTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWDLSMSISgiNETPLHSF 704

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 119628031 278 QGnvHNFEKNLLRCSWSpDGSkIAAGSADRFVYVW 312
Cdd:PLN00181 705 MG--HTNVKNFVGLSVS-DGY-IATGSETNEVFVY 735
PTZ00421 PTZ00421
coronin; Provisional
 53-229 2.17e-18

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 86.10  E-value: 2.17e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031  53 SSLQAPIMLLSGHEGEVYCCKFHPNG-STLASAGFDRLILLWNV-YGDCDNyaTLKGHSGAVMELHYNTDGSMLFSASTD 130
Cdd:PTZ00421 112 QNISDPIVHLQGHTKKVGIVSFHPSAmNVLASAGADMVVNVWDVeRGKAVE--VIKCHSDQITSLEWNLDGSLLCTTSKD 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031 131 KTVAVWDSETGERVKRLKGHTSF-VNSCYPARRGPQLV---CTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTF----N 202
Cdd:PTZ00421 190 KKLNIIDPRDGTIVSSVEAHASAkSQRCLWAKRKDLIItlgCSKSQQRQIMLWDTRKMASPYSTVDLDQSSALFIpffdE 269

                        170       180
                 ....*....|....*....|....*..
gi 119628031 203 DTSDQIISGGIDNDIKVWDLRQNKLTY 229
Cdd:PTZ00421 270 DTNLLYIGSKGEGNIRCFELMNERLTF 296
PTZ00421 PTZ00421
coronin; Provisional
 105-314 1.09e-09

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 59.52  E-value: 1.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031 105 LKGHSGAVMELHYNT-DGSMLFSASTDKTVAVWD-------SETGERVKRLKGHtsfvnscyparrgpqlvctgsddgtv 176
Cdd:PTZ00421  71 LLGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGipeegltQNISDPIVHLQGH-------------------------- 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031 177 klwdiRKKAAIQTFQ-NTYQVLAvtfndtsdqiiSGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAM 255
Cdd:PTZ00421 125 -----TKKVGIVSFHpSAMNVLA-----------SAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSK 188

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 119628031 256 DNTVRVWDVRpfapkeRCVKIFQGNVHNFEKNlLRCSWSPDGSKI----AAGSADRFVYVWDT 314
Cdd:PTZ00421 189 DKKLNIIDPR------DGTIVSSVEAHASAKS-QRCLWAKRKDLIitlgCSKSQQRQIMLWDT 244
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 207-356 1.07e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 56.63  E-value: 1.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031 207 QIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDN-TVRVWDVrpfapkERCVKIfqGNVHNfe 285
Cdd:PLN00181 547 QVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDgSVKLWSI------NQGVSI--GTIKT-- 616

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 119628031 286 KNLLRCSWSPD--GSKIAAGSADRFVYVWDTTSRRI-LYKLPGHAGSINEVAFhPDEPIIISASSDKRLYMGEI 356
Cdd:PLN00181 617 KANICCVQFPSesGRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 58-94 1.33e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.00  E-value: 1.33e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 119628031    58 PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWN 94
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
58-94 9.53e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.73  E-value: 9.53e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 119628031   58 PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWN 94
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
225-263 2.40e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.57  E-value: 2.40e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 119628031  225 NKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWD 263
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 224-263 2.73e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 2.73e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 119628031   224 QNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWD 263
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
76-264 5.84e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 50.08  E-value: 5.84e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031  76 PNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLF-SASTDKTVAVWDSETGERVKRLKGHTSFV 154
Cdd:COG3391   34 GPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYvANSGSGRVSVIDLATGKVVATIPVGGGPR 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031 155 NSCYpARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDND-----IKVWDLRQNKLTY 229
Cdd:COG3391  114 GLAV-DPDGGRLYVADSGNGRVSVIDTATGKVVATIPVGAGPHGIAVDPDGKRLYVANSGSNtvsviVSVIDTATGKVVA 192

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 119628031 230 TMRGhADSVTGLSLSSEGSYLL--------SNAMDNTVRVWDV 264
Cdd:COG3391  193 TIPV-GGGPVGVAVSPDGRRLYvanrgsntSNGGSNTVSVIDL 234
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 103-137 6.29e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 6.29e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 119628031   103 ATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWD 137
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 140-180 1.06e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.06e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 119628031   140 TGERVKRLKGHTSFVNSCYPARRGPQLVcTGSDDGTVKLWD 180
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLA-SGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
103-137 1.21e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 1.21e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 119628031  103 ATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWD 137
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
141-180 1.29e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 1.29e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 119628031  141 GERVKRLKGHTSFVNSCYPARRGpQLVCTGSDDGTVKLWD 180
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 208-283 2.19e-05

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 45.83  E-value: 2.19e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 119628031  208 IISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHN 283
Cdd:pfam20426  97 ISCGNWENSFQVISLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGRSSEKRSRNTQTEFPR 172
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 316-353 2.54e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 2.54e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 119628031   316 SRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYM 353
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKL 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 272-313 6.53e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 6.53e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 119628031   272 RCVKIFQGNvhnfEKNLLRCSWSPDGSKIAAGSADRFVYVWD 313
Cdd:smart00320   3 ELLKTLKGH----TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
317-353 1.11e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 1.11e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 119628031  317 RRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYM 353
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKV 37
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
209-338 1.21e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 43.14  E-value: 1.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628031 209 ISGGIDNDIKVWDLRQNKLTYTMRgHADSVTGLSLSSEGSYLL-SNAMDNTVRVWDVRPFAPKERcvkIFQGN-VHNFEk 286
Cdd:COG3391   84 VANSGSGRVSVIDLATGKVVATIP-VGGGPRGLAVDPDGGRLYvADSGNGRVSVIDTATGKVVAT---IPVGAgPHGIA- 158

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 119628031 287 nllrcsWSPDGSKIAAGSAD-----RFVYVWDTTSRRILYKLPGhAGSINEVAFHPD 338
Cdd:COG3391  159 ------VDPDGKRLYVANSGsntvsVIVSVIDTATGKVVATIPV-GGGPVGVAVSPD 208
WD40 pfam00400
WD domain, G-beta repeat;
272-313 4.09e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 4.09e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 119628031  272 RCVKIFQGNvhnfEKNLLRCSWSPDGSKIAAGSADRFVYVWD 313
Cdd:pfam00400   2 KLLKTLEGH----TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 187-221 1.03e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 1.03e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 119628031   187 IQTFQN-TYQVLAVTFNDTSDQIISGGIDNDIKVWD 221
Cdd:smart00320   5 LKTLKGhTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
196-221 8.58e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 33.86  E-value: 8.58e-03
                          10        20
                  ....*....|....*....|....*.
gi 119628031  196 VLAVTFNDTSDQIISGGIDNDIKVWD 221
Cdd:pfam00400  14 VTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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