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Conserved domains on  [gi|137370721|gb|EBT72039|]
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hypothetical protein GOS_7227098 [marine metagenome]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 10451993)

TetR/AcrR family transcriptional regulator controls genes involved in a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TetR pfam13972
Bacterial transcriptional repressor; This family of bacterial transcriptional repressors is ...
 87-230 5.69e-54

Bacterial transcriptional repressor; This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The regulatory network in which TetR itself is involved is in being released in the presence of tetracycline, binding to the target operator, and repressing tetA transcription.


:

Pssm-ID: 433616  Cd Length: 143  Bit Score: 170.51  E-value: 5.69e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 137370721   87 YETQVDSFLRLPEGRALTVEDKTFYLEALLAAMWHYRFLHRDLEHLLESDAELAERYRAFAQRCLVRAQSIYQGFVEAGI 166
Cdd:pfam13972   1 YEEELLELLRPPSDRPLTLEDLWLYLHALFELMWRYRFLYRDLPDLLSRNPELAKRYRQLLARLLATLRALLQGLVEAGL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 137370721  167 LLMTPAQIEALTLNAWIIMTSWVRFLCTAgASPDNLSQDMLRRGIYQVLALEGGYIAPAAREAV 230
Cdd:pfam13972  81 LQADDEELEALADNIWLVATYWLSYQRTQ-APEAALTEAALRRGVYQVLSLLAPYLTPEGREAF 143
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
37-83 5.42e-08

Bacterial regulatory proteins, tetR family;


:

Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 47.79  E-value: 5.42e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 137370721   37 IVAESLALFNAQGERNVTTNHIAAHLGISPGNLYYHFRNKQMIIAEL 83
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
 
Name Accession Description Interval E-value
TetR pfam13972
Bacterial transcriptional repressor; This family of bacterial transcriptional repressors is ...
 87-230 5.69e-54

Bacterial transcriptional repressor; This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The regulatory network in which TetR itself is involved is in being released in the presence of tetracycline, binding to the target operator, and repressing tetA transcription.


Pssm-ID: 433616  Cd Length: 143  Bit Score: 170.51  E-value: 5.69e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 137370721   87 YETQVDSFLRLPEGRALTVEDKTFYLEALLAAMWHYRFLHRDLEHLLESDAELAERYRAFAQRCLVRAQSIYQGFVEAGI 166
Cdd:pfam13972   1 YEEELLELLRPPSDRPLTLEDLWLYLHALFELMWRYRFLYRDLPDLLSRNPELAKRYRQLLARLLATLRALLQGLVEAGL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 137370721  167 LLMTPAQIEALTLNAWIIMTSWVRFLCTAgASPDNLSQDMLRRGIYQVLALEGGYIAPAAREAV 230
Cdd:pfam13972  81 LQADDEELEALADNIWLVATYWLSYQRTQ-APEAALTEAALRRGVYQVLSLLAPYLTPEGREAF 143
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
30-183 2.33e-15

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 71.08  E-value: 2.33e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 137370721  30 PPKTRDRIVAESLALFNAQGERNVTTNHIAAHLGISPGNLYYHFRNKQMIIAELFAQYETQVDSFLRLPEGRALTVEDKT 109
Cdd:COG1309    4 REATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEDPRERLR 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 137370721 110 FYLEALLAAMWHYRFLHRDLEHLLESDAELAERYRAFAQRCLVRaqsIYQGFVEAGILLMTPAQIEALTLNAWI 183
Cdd:COG1309   84 ALLRAYLEFLAENPALARLLLAEAAELPELRAALRALLRRLRAL---LAELLRAGGLLADVDPDALARALLALL 154
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
37-83 5.42e-08

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 47.79  E-value: 5.42e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 137370721   37 IVAESLALFNAQGERNVTTNHIAAHLGISPGNLYYHFRNKQMIIAEL 83
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
PRK10668 PRK10668
DNA-binding transcriptional repressor AcrR; Provisional
 33-94 9.55e-05

DNA-binding transcriptional repressor AcrR; Provisional


Pssm-ID: 182632 [Multi-domain]  Cd Length: 215  Bit Score: 42.30  E-value: 9.55e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 137370721  33 TRDRIVAESLALFNAQGERNVTTNHIAAHLGISPGNLYYHFRNKQMIIAELFAQYETQVDSF 94
Cdd:PRK10668  12 TRQHILDAALRLFSQQGVSATSLADIAKAAGVTRGAIYWHFKNKSDLFSEIWELSESKIGEL 73
 
Name Accession Description Interval E-value
TetR pfam13972
Bacterial transcriptional repressor; This family of bacterial transcriptional repressors is ...
 87-230 5.69e-54

Bacterial transcriptional repressor; This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The regulatory network in which TetR itself is involved is in being released in the presence of tetracycline, binding to the target operator, and repressing tetA transcription.


Pssm-ID: 433616  Cd Length: 143  Bit Score: 170.51  E-value: 5.69e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 137370721   87 YETQVDSFLRLPEGRALTVEDKTFYLEALLAAMWHYRFLHRDLEHLLESDAELAERYRAFAQRCLVRAQSIYQGFVEAGI 166
Cdd:pfam13972   1 YEEELLELLRPPSDRPLTLEDLWLYLHALFELMWRYRFLYRDLPDLLSRNPELAKRYRQLLARLLATLRALLQGLVEAGL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 137370721  167 LLMTPAQIEALTLNAWIIMTSWVRFLCTAgASPDNLSQDMLRRGIYQVLALEGGYIAPAAREAV 230
Cdd:pfam13972  81 LQADDEELEALADNIWLVATYWLSYQRTQ-APEAALTEAALRRGVYQVLSLLAPYLTPEGREAF 143
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
30-183 2.33e-15

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 71.08  E-value: 2.33e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 137370721  30 PPKTRDRIVAESLALFNAQGERNVTTNHIAAHLGISPGNLYYHFRNKQMIIAELFAQYETQVDSFLRLPEGRALTVEDKT 109
Cdd:COG1309    4 REATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEDPRERLR 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 137370721 110 FYLEALLAAMWHYRFLHRDLEHLLESDAELAERYRAFAQRCLVRaqsIYQGFVEAGILLMTPAQIEALTLNAWI 183
Cdd:COG1309   84 ALLRAYLEFLAENPALARLLLAEAAELPELRAALRALLRRLRAL---LAELLRAGGLLADVDPDALARALLALL 154
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
37-83 5.42e-08

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 47.79  E-value: 5.42e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 137370721   37 IVAESLALFNAQGERNVTTNHIAAHLGISPGNLYYHFRNKQMIIAEL 83
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
YbjK COG3226
DNA-binding transcriptional regulator YbjK [Transcription];
30-178 1.38e-06

DNA-binding transcriptional regulator YbjK [Transcription];


Pssm-ID: 442459 [Multi-domain]  Cd Length: 191  Bit Score: 47.24  E-value: 1.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 137370721  30 PPKTRDRIVAESLALFNAQGERNVTTNHIAAHLGISPGNLYYHFRNKQMIIAELFAQYetqVDSFLRLPEGRALTVEDKT 109
Cdd:COG3226    6 GEERRERILEAALRVIARDGVRGVTHRAVAAEAGVPLGSTTYYFRTRDELLAAAFERL---AEREAARLRALLAAADDLE 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 137370721 110 FYLEALLAAMWHYRFLHRD---LEHLLESDAELAERYRAFAQRCLVRAQSIYQGFVEAGILLMTPAQIEALT 178
Cdd:COG3226   83 DAAEALADLLAELLPADRDrllARYELYLEALRDPELRALLRRWRDRLREALARLLAALGSPDPPETARALV 154
PRK10668 PRK10668
DNA-binding transcriptional repressor AcrR; Provisional
 33-94 9.55e-05

DNA-binding transcriptional repressor AcrR; Provisional


Pssm-ID: 182632 [Multi-domain]  Cd Length: 215  Bit Score: 42.30  E-value: 9.55e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 137370721  33 TRDRIVAESLALFNAQGERNVTTNHIAAHLGISPGNLYYHFRNKQMIIAELFAQYETQVDSF 94
Cdd:PRK10668  12 TRQHILDAALRLFSQQGVSATSLADIAKAAGVTRGAIYWHFKNKSDLFSEIWELSESKIGEL 73
PRK09975 PRK09975
DNA-binding transcriptional regulator EnvR; Provisional
 32-86 7.90e-04

DNA-binding transcriptional regulator EnvR; Provisional


Pssm-ID: 182177 [Multi-domain]  Cd Length: 213  Bit Score: 39.34  E-value: 7.90e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 137370721  32 KTRDRIVAESLALFNAQGERNVTTNHIAAHLGISPGNLYYHFRNKQMIIAELFAQ 86
Cdd:PRK09975  11 KTRQELIETAIAQFALRGVSNTTLNDIADAANVTRGAIYWHFENKTQLFNEMWLQ 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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