NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|148665498|gb|EDK97914|]
View 

mCG130182, isoform CRA_a [Mus musculus]

Protein Classification

CY domain-containing protein( domain architecture ID 10440427)

CY domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 4-90 4.21e-24

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


:

Pssm-ID: 425431  Cd Length: 92  Bit Score: 87.39  E-value: 4.21e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148665498   4 GGLSRARSATPEIQEIADKVKSLLEEKT-NEKYEVFKAVEYKSQVVAGQNYFIKMDVGGGCFL-HIKVFKGISGENV--L 79
Cdd:pfam00031  1 GGLSPIPDNSPELQEALDFALAEYNAKTdNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSkSKKLLEDCPLLDEkwL 80

                         90
                 ....*....|.
gi 148665498  80 ELHGYQTNKTR 90
Cdd:pfam00031 81 GLCSAQVYKVP 91
 
Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 4-90 4.21e-24

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 87.39  E-value: 4.21e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148665498   4 GGLSRARSATPEIQEIADKVKSLLEEKT-NEKYEVFKAVEYKSQVVAGQNYFIKMDVGGGCFL-HIKVFKGISGENV--L 79
Cdd:pfam00031  1 GGLSPIPDNSPELQEALDFALAEYNAKTdNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSkSKKLLEDCPLLDEkwL 80

                         90
                 ....*....|.
gi 148665498  80 ELHGYQTNKTR 90
Cdd:pfam00031 81 GLCSAQVYKVP 91
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 1-62 6.54e-18

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 72.08  E-value: 6.54e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 148665498     1 MMPGGLSRARSATPEIQEIADKVKSLLEEKTNEKYE--VFKAVEYKSQVVAGQNYFIKMDVGGG 62
Cdd:smart00043   1 LCLGGPSDVPPNDPEVQEAADFAVAEYNKKSNDKYElrVIKVVSAKSQVVAGTNYYLKVEVGET 64
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 14-60 1.45e-12

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 58.25  E-value: 1.45e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 148665498  14 PEIQEIADKVKSLLEEKTNEKY-EVFKAVEYKSQVVAGQNYFIKMDVG 60
Cdd:cd00042   11 PEVQELADFAVAEYNKKSNDKYlEFFKVLSAKSQVVAGTNYYITVEAG 58
 
Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 4-90 4.21e-24

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 87.39  E-value: 4.21e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148665498   4 GGLSRARSATPEIQEIADKVKSLLEEKT-NEKYEVFKAVEYKSQVVAGQNYFIKMDVGGGCFL-HIKVFKGISGENV--L 79
Cdd:pfam00031  1 GGLSPIPDNSPELQEALDFALAEYNAKTdNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSkSKKLLEDCPLLDEkwL 80

                         90
                 ....*....|.
gi 148665498  80 ELHGYQTNKTR 90
Cdd:pfam00031 81 GLCSAQVYKVP 91
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 1-62 6.54e-18

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 72.08  E-value: 6.54e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 148665498     1 MMPGGLSRARSATPEIQEIADKVKSLLEEKTNEKYE--VFKAVEYKSQVVAGQNYFIKMDVGGG 62
Cdd:smart00043   1 LCLGGPSDVPPNDPEVQEAADFAVAEYNKKSNDKYElrVIKVVSAKSQVVAGTNYYLKVEVGET 64
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 14-60 1.45e-12

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 58.25  E-value: 1.45e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 148665498  14 PEIQEIADKVKSLLEEKTNEKY-EVFKAVEYKSQVVAGQNYFIKMDVG 60
Cdd:cd00042   11 PEVQELADFAVAEYNKKSNDKYlEFFKVLSAKSQVVAGTNYYITVEAG 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH