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Conserved domains on  [gi|148667470|gb|EDK99886|]
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FK506 binding protein 4, isoform CRA_a [Mus musculus]

Protein Classification

FKBP-type peptidyl-prolyl cis-trans isomerase( domain architecture ID 10446594)

FKBP-type peptidyl-prolyl cis-trans isomerase acts as a PPIase that accelerates the folding of proteins

CATH:  3.10.50.40
EC:  5.2.1.8
Gene Ontology:  GO:0003755|GO:0000413|GO:0061077
PubMed:  27664121
SCOP:  4001062

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
40-131 7.72e-44

FKBP-type peptidyl-prolyl cis-trans isomerase;


:

Pssm-ID: 459735  Cd Length: 94  Bit Score: 148.88  E-value: 7.72e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470   40 GTETPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAVATMKVGEVCHITCKPEYAYGAAGS-PPK 118
Cdd:pfam00254   1 GPEKAKKGDRVTVHYTGTLEDGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLaGPV 80

                          90
                  ....*....|...
gi 148667470  119 IPPNATLVFEVEL 131
Cdd:pfam00254  81 IPPNATLVFEVEL 93
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
212-421 1.75e-17

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 81.11  E-value: 1.75e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470 212 EHSIVYLKPSYAFGSVGKERFQIPPHAELRYEVRLKSFEKAKESWEmSSAEKLEQSNIVKERGTAYFKEGKYKQALLQYK 291
Cdd:COG4785   19 ASKAAILLAALLFAAVLALAIALADLALALAAAALAAAALAAERID-RALALPDLAQLYYERGVAYDSLGDYDLAIADFD 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470 292 KivswleyessfsgeemqkvhALRL-----ASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDF 366
Cdd:COG4785   98 Q--------------------ALELdpdlaEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRY 157

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 148667470 367 DLARADFQKVLQLYPSNKAAKTQLAVCQQRTRRQLAREKKLYANMFERLAEEEHK 421
Cdd:COG4785  158 ELAIADLEKALELDPNDPERALWLYLAERKLDPEKALALLLEDWATAYLLQGDTE 212
 
Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
40-131 7.72e-44

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 148.88  E-value: 7.72e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470   40 GTETPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAVATMKVGEVCHITCKPEYAYGAAGS-PPK 118
Cdd:pfam00254   1 GPEKAKKGDRVTVHYTGTLEDGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLaGPV 80

                          90
                  ....*....|...
gi 148667470  119 IPPNATLVFEVEL 131
Cdd:pfam00254  81 IPPNATLVFEVEL 93
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 33-131 3.38e-42

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 144.94  E-value: 3.38e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470  33 VIKREGTGtETPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAVATMKVGEVCHITCKPEYAYGA 112
Cdd:COG0545    4 KVLKEGTG-AKPKAGDTVTVHYTGTLLDGTVFDSSYDRGEPATFPLGVGQVIPGWDEGLQGMKVGGKRRLVIPPELAYGE 82

                         90
                 ....*....|....*....
gi 148667470 113 AGSPPKIPPNATLVFEVEL 131
Cdd:COG0545   83 RGAGGVIPPNSTLVFEVEL 101
PRK10902 PRK10902
FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional
 34-135 4.29e-18

FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 236791 [Multi-domain]  Cd Length: 269  Bit Score: 84.04  E-value: 4.29e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470  34 IKREGTGtETPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKgeVIKAWDIAVATMKVGEVCHITCKPEYAYGAA 113
Cdd:PRK10902 152 VEKEGTG-EAPKDSDTVVVNYKGTLIDGKEFDNSYTRGEPLSFRLDG--VIPGWTEGLKNIKKGGKIKLVIPPELAYGKA 228

                         90       100
                 ....*....|....*....|..
gi 148667470 114 GSpPKIPPNATLVFEVELFEFK 135
Cdd:PRK10902 229 GV-PGIPANSTLVFDVELLDVK 249
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
212-421 1.75e-17

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 81.11  E-value: 1.75e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470 212 EHSIVYLKPSYAFGSVGKERFQIPPHAELRYEVRLKSFEKAKESWEmSSAEKLEQSNIVKERGTAYFKEGKYKQALLQYK 291
Cdd:COG4785   19 ASKAAILLAALLFAAVLALAIALADLALALAAAALAAAALAAERID-RALALPDLAQLYYERGVAYDSLGDYDLAIADFD 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470 292 KivswleyessfsgeemqkvhALRL-----ASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDF 366
Cdd:COG4785   98 Q--------------------ALELdpdlaEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRY 157

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 148667470 367 DLARADFQKVLQLYPSNKAAKTQLAVCQQRTRRQLAREKKLYANMFERLAEEEHK 421
Cdd:COG4785  158 ELAIADLEKALELDPNDPERALWLYLAERKLDPEKALALLLEDWATAYLLQGDTE 212
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 233-392 8.31e-09

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 57.79  E-value: 8.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470  233 QIPPHAELRY-----EVRLKSFEKAKESWEMSSAEKLEQSNIVKERGTAYFKEGKYKQALLQYKKIVSWLEyessfsgee 307
Cdd:TIGR02917 256 KAPNSPLAHYlkalvDFQKKNYEDARETLQDALKSAPEYLPALLLAGASEYQLGNLEQAYQYLNQILKYAP--------- 326

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470  308 mQKVHALRLashlnLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAK 387
Cdd:TIGR02917 327 -NSHQARRL-----LASIQLRLGRVDEAIATLSPALGLDPDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPENAAAR 400


                  ....*
gi 148667470  388 TQLAV 392
Cdd:TIGR02917 401 TQLGI 405
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 320-387 2.17e-06

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 49.16  E-value: 2.17e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 148667470 320 LNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAK 387
Cdd:cd24142    4 LEKAEELLDQGNFELALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDPDGGYEK 71
TPR_1 pfam00515
Tetratricopeptide repeat;
318-349 4.58e-05

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 40.10  E-value: 4.58e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 148667470  318 SHLNLAMCHLKLQAFSAAIESCNKALELDSNN 349
Cdd:pfam00515   3 ALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 323-436 8.38e-05

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 44.39  E-value: 8.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470 323 AMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNkaaktqlavcqqrtrrqlA 402
Cdd:PLN03088  43 AQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGTACMKLEEYQTAKAALEKGASLAPGD------------------S 104

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 148667470 403 REKKLYANMFERLAEEE-----HKVKAEVAAGDHPTDAE 436
Cdd:PLN03088 105 RFTKLIKECDEKIAEEEkdlvqPVPSDLPSSVTAPPVEE 143
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 319-349 8.77e-05

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 39.35  E-value: 8.77e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 148667470   319 HLNLAMCHLKLQAFSAAIESCNKALELDSNN 349
Cdd:smart00028   4 LYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
 
Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
40-131 7.72e-44

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 148.88  E-value: 7.72e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470   40 GTETPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAVATMKVGEVCHITCKPEYAYGAAGS-PPK 118
Cdd:pfam00254   1 GPEKAKKGDRVTVHYTGTLEDGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLaGPV 80

                          90
                  ....*....|...
gi 148667470  119 IPPNATLVFEVEL 131
Cdd:pfam00254  81 IPPNATLVFEVEL 93
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 33-131 3.38e-42

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 144.94  E-value: 3.38e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470  33 VIKREGTGtETPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAVATMKVGEVCHITCKPEYAYGA 112
Cdd:COG0545    4 KVLKEGTG-AKPKAGDTVTVHYTGTLLDGTVFDSSYDRGEPATFPLGVGQVIPGWDEGLQGMKVGGKRRLVIPPELAYGE 82

                         90
                 ....*....|....*....
gi 148667470 113 AGSPPKIPPNATLVFEVEL 131
Cdd:COG0545   83 RGAGGVIPPNSTLVFEVEL 101
PRK10902 PRK10902
FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional
 34-135 4.29e-18

FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 236791 [Multi-domain]  Cd Length: 269  Bit Score: 84.04  E-value: 4.29e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470  34 IKREGTGtETPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKgeVIKAWDIAVATMKVGEVCHITCKPEYAYGAA 113
Cdd:PRK10902 152 VEKEGTG-EAPKDSDTVVVNYKGTLIDGKEFDNSYTRGEPLSFRLDG--VIPGWTEGLKNIKKGGKIKLVIPPELAYGKA 228

                         90       100
                 ....*....|....*....|..
gi 148667470 114 GSpPKIPPNATLVFEVELFEFK 135
Cdd:PRK10902 229 GV-PGIPANSTLVFDVELLDVK 249
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
212-421 1.75e-17

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 81.11  E-value: 1.75e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470 212 EHSIVYLKPSYAFGSVGKERFQIPPHAELRYEVRLKSFEKAKESWEmSSAEKLEQSNIVKERGTAYFKEGKYKQALLQYK 291
Cdd:COG4785   19 ASKAAILLAALLFAAVLALAIALADLALALAAAALAAAALAAERID-RALALPDLAQLYYERGVAYDSLGDYDLAIADFD 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470 292 KivswleyessfsgeemqkvhALRL-----ASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDF 366
Cdd:COG4785   98 Q--------------------ALELdpdlaEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRY 157

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 148667470 367 DLARADFQKVLQLYPSNKAAKTQLAVCQQRTRRQLAREKKLYANMFERLAEEEHK 421
Cdd:COG4785  158 ELAIADLEKALELDPNDPERALWLYLAERKLDPEKALALLLEDWATAYLLQGDTE 212
PRK11570 PRK11570
peptidyl-prolyl cis-trans isomerase; Provisional
 28-133 6.24e-17

peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 183207 [Multi-domain]  Cd Length: 206  Bit Score: 79.07  E-value: 6.24e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470  28 KQDEGVIkregtgtetPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKgeVIKAWDIAVATMKVGEVCHITCKPE 107
Cdd:PRK11570 110 TQGEGAI---------PARTDRVRVHYTGKLIDGTVFDSSVARGEPAEFPVNG--VIPGWIEALTLMPVGSKWELTIPHE 178

                         90       100
                 ....*....|....*....|....*.
gi 148667470 108 YAYGAAGSPPKIPPNATLVFEVELFE 133
Cdd:PRK11570 179 LAYGERGAGASIPPFSTLVFEVELLE 204
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
245-455 1.50e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 70.04  E-value: 1.50e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470 245 RLKSFEKAKESWEMSSAEKLEQSNIVKERGTAYFKEGKYKQALLQYKKivswleyessfsgeemqkvhALRL-----ASH 319
Cdd:COG0457   20 RLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQ--------------------ALELdpddaEAL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470 320 LNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVC---QQR 396
Cdd:COG0457   80 NNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIAlekLGR 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 148667470 397 TRRQLAREKKLYANMFERLAEEEHKVKAEVAAGDHPTDAEMKGERNNVAENQSRVETEA 455
Cdd:COG0457  160 YEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAA 218
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
273-399 1.55e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 67.34  E-value: 1.55e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470 273 RGTAYFKEGKYKQALLQYKKIVswleyessfsgeEMQKVHAlrlASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKG 352
Cdd:COG0457   14 LGLAYRRLGRYEEAIEDYEKAL------------ELDPDDA---EALYNLGLAYLRLGRYEEALADYEQALELDPDDAEA 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 148667470 353 LFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTRR 399
Cdd:COG0457   79 LNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGR 125
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 233-397 5.00e-12

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 68.10  E-value: 5.00e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470 233 QIPPHAELRYEVRLKSFEKAKESWEMSSAEKLEQSNIVKERGTAYFKEGKYKQALLQYKKIvswLEYESSFsgeemqkvh 312
Cdd:COG3914   78 AALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRA---LALNPDF--------- 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470 313 alrLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAV 392
Cdd:COG3914  146 ---AEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLF 222


                 ....*
gi 148667470 393 CQQRT 397
Cdd:COG3914  223 ALRQA 227
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 264-399 1.64e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 66.17  E-value: 1.64e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470 264 LEQSNIVKERGTAYFKEGKYKQALLQYKKIVswleyessfsgeemqKVHALRLASHLNLAMCHLKLQAFSAAIESCNKAL 343
Cdd:COG3914   75 LLLAALLELAALLLQALGRYEEALALYRRAL---------------ALNPDNAEALFNLGNLLLALGRLEEALAALRRAL 139

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 148667470 344 ELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTRR 399
Cdd:COG3914  140 ALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGR 195
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 245-450 3.11e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 63.59  E-value: 3.11e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470 245 RLKSFEKAKESWEMSSAEKLEQSNIVKERGTAYFKEGKYKQALLQYKKIVSWLEYESSFsgeemqkvhalrlasHLNLAM 324
Cdd:COG2956   88 KAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHA---------------YCELAE 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470 325 CHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTRRQLARE 404
Cdd:COG2956  153 LYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEAL 232

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 148667470 405 KKLyanmfERLAEEEHKVKAEVAAGDHPTDAEMKGERNNVAENQSR 450
Cdd:COG2956  233 ELL-----RKALELDPSDDLLLALADLLERKEGLEAALALLERQLR 273
SlpA COG1047
Peptidyl-prolyl cis-trans isomerase, FKBP type [Posttranslational modification, protein ...
 47-142 9.74e-11

Peptidyl-prolyl cis-trans isomerase, FKBP type [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440668 [Multi-domain]  Cd Length: 138  Bit Score: 59.34  E-value: 9.74e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470  47 GDRVFVHYTGWLLDGTKFDSSLDRkDKFSFDLGKGEVIKAWDIAVATMKVGEVCHITCKPEYAYGaagsppkiPPNATLV 126
Cdd:COG1047    4 GDVVTLHYTLKLEDGEVFDSTFEG-EPLEFLHGAGQLIPGLEEALEGMEVGDKKTVTLPPEEAYG--------ERDPELV 74

                         90
                 ....*....|....*.
gi 148667470 127 FEVELFEFKGEDLTEE 142
Cdd:COG1047   75 QTVPREQFPEDEELEV 90
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 276-387 1.87e-10

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 58.08  E-value: 1.87e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470 276 AYFKEGKYKQALLQYKKIVSwlEYESSfsgeemqkvhALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEK---G 352
Cdd:COG1729    2 ALLKAGDYDEAIAAFKAFLK--RYPNS----------PLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKapdA 69

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 148667470 353 LFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAK 387
Cdd:COG1729   70 LLKLGLSYLELGDYDKARATLEELIKKYPDSEAAK 104
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
318-399 1.96e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 60.79  E-value: 1.96e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470 318 SHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRT 397
Cdd:COG0457   10 AYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQAL 89


                 ..
gi 148667470 398 RR 399
Cdd:COG0457   90 GR 91
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 272-399 3.90e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 60.51  E-value: 3.90e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470 272 ERGTAYFKEGKYKQALLQYKKIVswleyessfsgeemqKVHALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEK 351
Cdd:COG2956   13 FKGLNYLLNGQPDKAIDLLEEAL---------------ELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAE 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 148667470 352 GLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTRR 399
Cdd:COG2956   78 ALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGD 125
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 319-404 4.40e-10

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 57.32  E-value: 4.40e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470 319 HLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVC-QQRT 397
Cdd:COG4235   20 WLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAaFQQG 99


                 ....*..
gi 148667470 398 RRQLARE 404
Cdd:COG4235  100 DYAEAIA 106
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 274-386 5.71e-10

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 56.94  E-value: 5.71e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470 274 GTAYFKEGKYKQALLQYKKivswleyessfsgeemqkvhALRLAS-----HLNLAMCHLKLQAFSAAIESCNKALELDSN 348
Cdd:COG4235   24 GRAYLRLGRYDEALAAYEK--------------------ALRLDPdnadaLLDLAEALLAAGDTEEAEELLERALALDPD 83

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 148667470 349 NEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAA 386
Cdd:COG4235   84 NPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAPA 121
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 245-417 2.86e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 57.82  E-value: 2.86e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470 245 RLKSFEKAKESWEMSSAEKLEQSNIVKERGTAYFKEGKYKQALLQYKKIVSwleyessfsgEEMQKVHALRLashlnLAM 324
Cdd:COG2956   54 RRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLE----------LDPDDAEALRL-----LAE 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470 325 CHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTR------ 398
Cdd:COG2956  119 IYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGdyeeai 198

                        170       180
                 ....*....|....*....|..
gi 148667470 399 ---RQLAREKKLYANMFERLAE 417
Cdd:COG2956  199 aalERALEQDPDYLPALPRLAE 220
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 273-383 2.89e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 55.20  E-value: 2.89e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470 273 RGTAYFKEGKYKQALLQYKKIVswleyessfsgeemqKVHALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKG 352
Cdd:COG4783   44 LGEILLQLGDLDEAIVLLHEAL---------------ELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEA 108

                         90       100       110
                 ....*....|....*....|....*....|.
gi 148667470 353 LFRRGEAHLAVNDFDLARADFQKVLQLYPSN 383
Cdd:COG4783  109 YLRLARAYRALGRPDEAIAALEKALELDPDD 139
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 233-392 8.31e-09

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 57.79  E-value: 8.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470  233 QIPPHAELRY-----EVRLKSFEKAKESWEMSSAEKLEQSNIVKERGTAYFKEGKYKQALLQYKKIVSWLEyessfsgee 307
Cdd:TIGR02917 256 KAPNSPLAHYlkalvDFQKKNYEDARETLQDALKSAPEYLPALLLAGASEYQLGNLEQAYQYLNQILKYAP--------- 326

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470  308 mQKVHALRLashlnLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAK 387
Cdd:TIGR02917 327 -NSHQARRL-----LASIQLRLGRVDEAIATLSPALGLDPDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPENAAAR 400


                  ....*
gi 148667470  388 TQLAV 392
Cdd:TIGR02917 401 TQLGI 405
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
276-382 1.95e-08

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 51.71  E-value: 1.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470 276 AYFKEGKYKQALLQYKKIVswleyessfsgeemqKVHALRLASHLNLAMCHLKLQAFSAAIEsCNKALELDSNNEKGLFR 355
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKAL---------------ELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLN 64

                         90       100
                 ....*....|....*....|....*..
gi 148667470 356 RGEAHLAVNDFDLARADFQKVLQLYPS 382
Cdd:COG3063   65 LAELLLELGDYDEALAYLERALELDPS 91
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 313-407 2.40e-08

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 53.04  E-value: 2.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470 313 ALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAV 392
Cdd:COG5010   51 AKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAA 130

                         90
                 ....*....|....*
gi 148667470 393 CQQRTRRQLAREKKL 407
Cdd:COG5010  131 LLLSLGQDDEAKAAL 145
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 272-407 2.73e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 52.50  E-value: 2.73e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470 272 ERGTAYFKEGKYKQALLQYKKIVswleyessfsgeemqKVHALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEK 351
Cdd:COG4783    9 ALAQALLLAGDYDEAEALLEKAL---------------ELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPE 73

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 148667470 352 GLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTRRQLAREKKL 407
Cdd:COG4783   74 ARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAAL 129
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 238-381 1.52e-07

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 50.73  E-value: 1.52e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470 238 AELRYEVRLKSFEKAKESWEMSSAEKLEQSNIVKERGTAYFKEGKYKQALLQYKKIVSWLEYESSFsgeemqkvhalrla 317
Cdd:COG5010   25 EKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPEL-------------- 90

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 148667470 318 sHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYP 381
Cdd:COG5010   91 -YYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 334-391 1.61e-07

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 50.00  E-value: 1.61e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 148667470 334 AAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLA 391
Cdd:COG4235    1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLA 58
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 242-396 5.52e-07

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 51.91  E-value: 5.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470  242 YEVRLKSFEKAKESWEMSSAEKLEqsniVKERGTAYFKEGKYKQALLQYKKIVswlEYESSFSgeemqkvhalrlASHLN 321
Cdd:TIGR00990 310 YEEAARAFEKALDLGKLGEKEAIA----LNLRGTFKCLKGKHLEALADLSKSI---ELDPRVT------------QSYIK 370

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 148667470  322 LAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQR 396
Cdd:TIGR00990 371 RASMNLELGDPDKAEEDFDKALKLNSEDPDIYYHRAQLHFIKGEFAQAGKDYQKSIDLDPDFIFSHIQLGVTQYK 445
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 304-436 1.47e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 50.85  E-value: 1.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470  304 SGEEMQKVHALrlaSHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSN 383
Cdd:TIGR02917 456 KLEKKQPDNAS---LHNLLGAIYLGKGDLAKAREAFEKALSIEPDFFPAAANLARIDIQEGNPDDAIQRFEKVLTIDPKN 532

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 148667470  384 KAAKTQLAVCQQRTRRqlarekklyanmferlaEEEHKVKAEVAAGDHPTDAE 436
Cdd:TIGR02917 533 LRAILALAGLYLRTGN-----------------EEEAVAWLEKAAELNPQEIE 568
COG4700 COG4700
Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];
261-416 2.02e-06

Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];


Pssm-ID: 443735 [Multi-domain]  Cd Length: 249  Bit Score: 48.72  E-value: 2.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470 261 AEKLEQSNIVKER---GTAYFKEGKYKQALLQYkkivswleyESSFSGEEMQKVHALrlashLNLAMCHLKLQAFSAAIE 337
Cdd:COG4700   80 EKALEFADTVQNRvrlADALLELGRYDEAIELY---------EEALTGIFADDPHIL-----LGLAQALFELGRYAEALE 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470 338 SCNKALELDSNnekglFRRGEAHL-------AVNDFDLARADFQKVLQLYPsNKAAKTQLAVCQQRTRRQlAREKKLYAN 410
Cdd:COG4700  146 TLEKLIAKNPD-----FKSSDAHLlyaraleALGDLEAAEAELEALARRYS-GPEARYRYAKFLARQGRT-AEAKELLEE 218


                 ....*.
gi 148667470 411 MFERLA 416
Cdd:COG4700  219 ILDEAK 224
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 313-399 2.06e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 47.11  E-value: 2.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470 313 ALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAV 392
Cdd:COG4783    1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGL 80


                 ....*..
gi 148667470 393 CQQRTRR 399
Cdd:COG4783   81 ALLKAGD 87
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 320-387 2.17e-06

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 49.16  E-value: 2.17e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 148667470 320 LNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAK 387
Cdd:cd24142    4 LEKAEELLDQGNFELALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDPDGGYEK 71
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
325-399 3.71e-06

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 45.16  E-value: 3.71e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 148667470 325 CHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARAdFQKVLQLYPSNKAAKTQLAVCQQRTRR 399
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGD 74
TPR_1 pfam00515
Tetratricopeptide repeat;
318-349 4.58e-05

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 40.10  E-value: 4.58e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 148667470  318 SHLNLAMCHLKLQAFSAAIESCNKALELDSNN 349
Cdd:pfam00515   3 ALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
BamD COG4105
Outer membrane protein assembly factor BamD, BamD/ComL family [Cell wall/membrane/envelope ...
 248-403 5.97e-05

Outer membrane protein assembly factor BamD, BamD/ComL family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443281 [Multi-domain]  Cd Length: 254  Bit Score: 44.49  E-value: 5.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470 248 SFEKAKESWemsSAEKLeqsnivKERGTAYFKEGKYKQALLQYKKIVSWLEYessfsGEEMQKVhalrlasHLNLAMCHL 327
Cdd:COG4105   22 SFKKALKSW---DAEEL------YEEAKEALEKGDYEKAIKLFEELEPRYPG-----SPYAEQA-------QLMLAYAYY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470 328 KLQAFSAAIESCNKALELDSNNEK---GLFRRGEAH-LAVNDFDL-------ARADFQKVLQLYP-SNKAAKtqlavCQQ 395
Cdd:COG4105   81 KQGDYEEAIAAADRFIKLYPNSPNadyAYYLRGLSYyEQSPDSDRdqtstrkAIEAFQELINRYPdSEYAED-----AKK 155

                        170
                 ....*....|.
gi 148667470 396 R---TRRQLAR 403
Cdd:COG4105  156 RideLRDKLAR 166
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 323-436 8.38e-05

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 44.39  E-value: 8.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470 323 AMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNkaaktqlavcqqrtrrqlA 402
Cdd:PLN03088  43 AQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGTACMKLEEYQTAKAALEKGASLAPGD------------------S 104

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 148667470 403 REKKLYANMFERLAEEE-----HKVKAEVAAGDHPTDAE 436
Cdd:PLN03088 105 RFTKLIKECDEKIAEEEkdlvqPVPSDLPSSVTAPPVEE 143
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 319-349 8.77e-05

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 39.35  E-value: 8.77e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 148667470   319 HLNLAMCHLKLQAFSAAIESCNKALELDSNN 349
Cdd:smart00028   4 LYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 243-405 1.14e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 44.69  E-value: 1.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470  243 EVRLKSFEKAKESWEmsSAEKLEQSNIVKERGTAYFK--EGKYKQALLQYKKIVSwleyessfsgEEMQKVHALRLASHL 320
Cdd:TIGR02917 135 YLGLGQLELAQKSYE--QALAIDPRSLYAKLGLAQLAlaENRFDEARALIDEVLT----------ADPGNVDALLLKGDL 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470  321 NLAmchlkLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYP-SNKAAKTQLAVCQQRTRR 399
Cdd:TIGR02917 203 LLS-----LGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEAEKHADALLKKAPnSPLAHYLKALVDFQKKNY 277


                  ....*.
gi 148667470  400 QLAREK 405
Cdd:TIGR02917 278 EDARET 283
OM_YfiO TIGR03302
outer membrane assembly lipoprotein YfiO; Members of this protein family include YfiO, a ...
 272-408 1.93e-04

outer membrane assembly lipoprotein YfiO; Members of this protein family include YfiO, a near-essential protein of the outer membrane, part of a complex involved in protein insertion into the bacterial outer membrane. Many proteins in this family are annotated as ComL, based on the involvement of this protein in natural transformation with exogenous DNA in Neisseria gonorrhoeae. This protein family shows sequence similarity to, but is distinct from, the tol-pal system protein YbgF (TIGR02795). [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274513 [Multi-domain]  Cd Length: 235  Bit Score: 42.92  E-value: 1.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470  272 ERGTAYFKEGKYKQALLQYKKIvswleyESSF-SGEEMQKvhalrlaSHLNLAMCHLKLQAFSAAIESCNKALELDSNNE 350
Cdd:TIGR03302  38 EEAKEALDSGDYTEAIKYFEAL------ESRYpFSPYAEQ-------AQLDLAYAYYKSGDYAEAIAAADRFIRLHPNHP 104

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 148667470  351 K---GLFRRGEAHLA-VNDFD-------LARADFQKVLQLYPSNK---AAKTQLAVCqqrtRRQLArEKKLY 408
Cdd:TIGR03302 105 DadyAYYLRGLSNYNqIDRVDrdqtaarEAFEAFQELIRRYPNSEyapDAKKRMDYL----RNRLA-GKELY 171
TPR_1 pfam00515
Tetratricopeptide repeat;
351-383 5.03e-04

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 37.40  E-value: 5.03e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 148667470  351 KGLFRRGEAHLAVNDFDLARADFQKVLQLYPSN 383
Cdd:pfam00515   2 KALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 313-419 5.52e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 41.64  E-value: 5.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470 313 ALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAv 392
Cdd:COG2956    5 VAAALGWYFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELA- 83

                         90       100       110
                 ....*....|....*....|....*....|
gi 148667470 393 cqqrtrrQLAREKKLYA---NMFERLAEEE 419
Cdd:COG2956   84 -------QDYLKAGLLDraeELLEKLLELD 106
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 351-381 2.07e-03

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 35.58  E-value: 2.07e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 148667470  351 KGLFRRGEAHLAVNDFDLARADFQKVLQLYP 381
Cdd:pfam07719   2 EALYNLGLAYYKLGDYEEALEAYEKALELDP 32
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
343-399 2.25e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 39.60  E-value: 2.25e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 148667470 343 LELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTRR 399
Cdd:COG0457    1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGR 57
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 351-383 2.46e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 35.50  E-value: 2.46e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 148667470   351 KGLFRRGEAHLAVNDFDLARADFQKVLQLYPSN 383
Cdd:smart00028   2 EALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 258-373 3.37e-03

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 39.97  E-value: 3.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470  258 MSSAEKLEQSNIVKERGTAYFKEGKYKQALLQYKKIVSWLEYESSFSgeemqkvhalrlashlNLAMCHLKLQAFSAAIE 337
Cdd:TIGR00990 118 LSEEERKKYAAKLKEKGNKAYRNKDFNKAIKLYSKAIECKPDPVYYS----------------NRAACHNALGDWEKVVE 181

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 148667470  338 SCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADF 373
Cdd:TIGR00990 182 DTTAALELDPDYSKALNRRANAYDGLGKYADALLDL 217
YfgM COG2976
Putative negative regulator of RcsB-dependent stress response, UPF0070 family [Signal ...
 276-383 5.60e-03

Putative negative regulator of RcsB-dependent stress response, UPF0070 family [Signal transduction mechanisms];


Pssm-ID: 442215 [Multi-domain]  Cd Length: 207  Bit Score: 37.91  E-value: 5.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470 276 AYFKEGKYKQALLQYKKIVSwleyesSFSGEEMQKVHALRLAShlnlamCHLKLQAFSAAIESCNKAlelDSNNEKGLF- 354
Cdd:COG2976   99 AAVDAGDLDKAAAQLQWVLD------NAKDPALKALARLRLAR------VLLAQKKYDEALATLDAV---KPEAFAALYa 163

                         90       100       110
                 ....*....|....*....|....*....|
gi 148667470 355 -RRGEAHLAVNDFDLARADFQKVLQLYPSN 383
Cdd:COG2976  164 eLRGDILLAQGDKAEARAAYQKALAALPED 193
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
245-417 7.50e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 38.06  E-value: 7.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470 245 RLKSFEKAKESWEMSSAEKLEQSNIVKERGTAYFKEGKYKQALLQYKKIvswLEYESSFSgeemqkvhalrlASHLNLAM 324
Cdd:COG0457   88 ALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERA---LELDPDDA------------DALYNLGI 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470 325 CHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTRRQLARE 404
Cdd:COG0457  153 ALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLA 232

                        170
                 ....*....|...
gi 148667470 405 KKLYANMFERLAE 417
Cdd:COG0457  233 LRLAALALYQYRA 245
TPR_12 pfam13424
Tetratricopeptide repeat;
314-382 7.52e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 35.44  E-value: 7.52e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 148667470  314 LRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKG--------LFRRGEAHLAVNDFDLARADFQKVLQLYPS 382
Cdd:pfam13424   1 DVATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPdhpltattLLNLGRLYLELGRYEEALELLERALALAEK 77
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 274-392 8.34e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.53  E-value: 8.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667470  274 GTAYFKEGKYKQALLQYKKIVSwleyessfSGEEMQKVHALrlashlnLAMCHLKLQAFSAAIESCNKALELDSNNE-KG 352
Cdd:TIGR02917  63 GKIYLALGDYAAAEKELRKALS--------LGYPKNQVLPL-------LARAYLLQGKFQQVLDELPGKTLLDDEGAaEL 127

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 148667470  353 LFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAV 392
Cdd:TIGR02917 128 LALRGLAYLGLGQLELAQKSYEQALAIDPRSLYAKLGLAQ 167
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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