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Conserved domains on  [gi|148686170|gb|EDL18117|]
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adaptor protein complex AP-2, alpha 2 subunit, isoform CRA_b, partial [Mus musculus]

Protein Classification

HEAT repeat domain-containing protein( domain architecture ID 1001770)

HEAT repeat domain-containing protein similar to the N-terminal region of various adaptins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Adaptin_N super family cl37648
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
 6-177 3.01e-56

Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.


The actual alignment was detected with superfamily member pfam01602:

Pssm-ID: 396262 [Multi-domain]  Cd Length: 523  Bit Score: 184.75  E-value: 3.01e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686170    6 EIKRINKELANIRSKFKGDKaldgYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTEKQIGYLFISVLVNSNSEL 85
Cdd:pfam01602   1 EEKRIQQELARILNSFRDDP----RKKKNAVKKLLYLIMLGEDISFLFFEVVKLVASKDFTLKRLGYLYLMLLAEESPDL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686170   86 IRLINNAIKNDLASRNPTFMGLALHCIANVGSREMAEAFAGEIPKILVAGDTMdsVKQSAALCLLRLYRTSPDLVPmgDW 165
Cdd:pfam01602  77 AILVTNSIQKDLQSPNQLIRGLALRTLSCIRVPELARDLAPDIKKLLVDRSPY--VRKKAALAILKLYRKSPDLVR--DF 152

                         170
                  ....*....|..
gi 148686170  166 TSRVVHLLNDQH 177
Cdd:pfam01602 153 VPELKELLSDKD 164
 
Name Accession Description Interval E-value
Adaptin_N pfam01602
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
 6-177 3.01e-56

Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.


Pssm-ID: 396262 [Multi-domain]  Cd Length: 523  Bit Score: 184.75  E-value: 3.01e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686170    6 EIKRINKELANIRSKFKGDKaldgYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTEKQIGYLFISVLVNSNSEL 85
Cdd:pfam01602   1 EEKRIQQELARILNSFRDDP----RKKKNAVKKLLYLIMLGEDISFLFFEVVKLVASKDFTLKRLGYLYLMLLAEESPDL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686170   86 IRLINNAIKNDLASRNPTFMGLALHCIANVGSREMAEAFAGEIPKILVAGDTMdsVKQSAALCLLRLYRTSPDLVPmgDW 165
Cdd:pfam01602  77 AILVTNSIQKDLQSPNQLIRGLALRTLSCIRVPELARDLAPDIKKLLVDRSPY--VRKKAALAILKLYRKSPDLVR--DF 152

                         170
                  ....*....|..
gi 148686170  166 TSRVVHLLNDQH 177
Cdd:pfam01602 153 VPELKELLSDKD 164
COG5096 COG5096
Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular ...
 30-161 1.81e-07

Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 227427 [Multi-domain]  Cd Length: 757  Bit Score: 50.11  E-value: 1.81e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686170  30 YSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLAL 109
Cdd:COG5096   34 YKKIDAMKKIIAQMSLGEDMSSLFPDVIKNVATRDVELKRLLYLYLERYAKLKPELALLAVNTIQKDLQDPNEEIRGFAL 113

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 148686170 110 HCIANVGSREMAEAFAGEIPKILVAGDTMdsVKQSAALCLLRLYRTSPDLVP 161
Cdd:COG5096  114 RTLSLLRVKELLGNIIDPIKKLLTDPHAY--VRKTAALAVAKLYRLDKDLYH 163
 
Name Accession Description Interval E-value
Adaptin_N pfam01602
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
 6-177 3.01e-56

Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.


Pssm-ID: 396262 [Multi-domain]  Cd Length: 523  Bit Score: 184.75  E-value: 3.01e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686170    6 EIKRINKELANIRSKFKGDKaldgYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTEKQIGYLFISVLVNSNSEL 85
Cdd:pfam01602   1 EEKRIQQELARILNSFRDDP----RKKKNAVKKLLYLIMLGEDISFLFFEVVKLVASKDFTLKRLGYLYLMLLAEESPDL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686170   86 IRLINNAIKNDLASRNPTFMGLALHCIANVGSREMAEAFAGEIPKILVAGDTMdsVKQSAALCLLRLYRTSPDLVPmgDW 165
Cdd:pfam01602  77 AILVTNSIQKDLQSPNQLIRGLALRTLSCIRVPELARDLAPDIKKLLVDRSPY--VRKKAALAILKLYRKSPDLVR--DF 152

                         170
                  ....*....|..
gi 148686170  166 TSRVVHLLNDQH 177
Cdd:pfam01602 153 VPELKELLSDKD 164
COG5096 COG5096
Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular ...
 30-161 1.81e-07

Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 227427 [Multi-domain]  Cd Length: 757  Bit Score: 50.11  E-value: 1.81e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686170  30 YSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLAL 109
Cdd:COG5096   34 YKKIDAMKKIIAQMSLGEDMSSLFPDVIKNVATRDVELKRLLYLYLERYAKLKPELALLAVNTIQKDLQDPNEEIRGFAL 113

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 148686170 110 HCIANVGSREMAEAFAGEIPKILVAGDTMdsVKQSAALCLLRLYRTSPDLVP 161
Cdd:COG5096  114 RTLSLLRVKELLGNIIDPIKKLLTDPHAY--VRKTAALAVAKLYRLDKDLYH 163
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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