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Conserved domains on  [gi|148686413|gb|EDL18360|]
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hyperpolarization-activated, cyclic nucleotide-gated K+ 1, partial [Mus musculus]

Protein Classification

Ion_trans_N and CAP_ED domain-containing protein( domain architecture ID 13750458)

Ion_trans_N and CAP_ED domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CAP_ED cd00038
effector domain of the CAP family of transcription factors; members include CAP (or cAMP ...
465-573 5.66e-28

effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels


:

Pssm-ID: 237999 [Multi-domain]  Cd Length: 115  Bit Score: 108.95  E-value: 5.66e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686413 465 LFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSS--KEMK---LTDGSYFGEICLLTKGRR 539
Cdd:cd00038    1 LFSGLDDEELEELADALEERRFPAGEVIIRQGDPADSLYIVLSGSVEVYKLDEdgREQIvgfLGPGDLFGELALLGNGPR 80
                         90       100       110
                 ....*....|....*....|....*....|....
gi 148686413 540 TASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAF 573
Cdd:cd00038   81 SATVRALTDSELLVLPRSDFRRLLQEYPELARRL 114
Ion_trans_N pfam08412
Ion transport protein N-terminal; This metazoan domain is found to the N-terminus of pfam00520 ...
88-130 8.53e-22

Ion transport protein N-terminal; This metazoan domain is found to the N-terminus of pfam00520 in voltage- and cyclic nucleotide-gated K/Na ion channels.


:

Pssm-ID: 400630  Cd Length: 43  Bit Score: 88.90  E-value: 8.53e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 148686413   88 FTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSD 130
Cdd:pfam08412   1 LKSLLQPSDNKLSMKLFGSKKAVEKEKERQKEAGVWIIHPCSN 43
PLN03192 super family cl33658
Voltage-dependent potassium channel; Provisional
123-610 9.71e-20

Voltage-dependent potassium channel; Provisional


The actual alignment was detected with superfamily member PLN03192:

Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 94.93  E-value: 9.71e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686413 123 WIIHPYsDFRF-YWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFRTGTVNEDSSEIILDPK 201
Cdd:PLN03192  52 WIISPM-DSRYrWWETLMVVLVAYSAWVYPFEVAFLNASPKRGLEIADNVVDLFFAVDIVLTFFVAYIDPRTQLLVRDRK 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686413 202 VIKMNYLKSWFVVDFISSIPVDYI-FLIVEKGMDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIhqWeeifhmtyd 280
Cdd:PLN03192 131 KIAVRYLSTWFLMDVASTIPFQALaYLITGTVKLNLSYSLLGLLRFWRLRRVKQLFTRLEKDIRFSYF--W--------- 199
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686413 281 lasavVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVS--LNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVS 358
Cdd:PLN03192 200 -----IRCARLLSVTLFLVHCAGCLYYLIADRYPHQGKTWIGavIPNFRETSLWIRYISAIYWSITTMTTVGYGDLHAVN 274
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686413 359 MSDLWITMLSMIVGATCYAMFVGHATALIqsLDSSRR--QYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDE 436
Cdd:PLN03192 275 TIEMIFIIFYMLFNLGLTAYLIGNMTNLV--VEGTRRtmEFRNSIEAASNFVGRNRLPPRLKDQILAYMCLRFKAESLNQ 352
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686413 437 ENILSELNDPLREEIvnfnCRKL----VATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGV 512
Cdd:PLN03192 353 QQLIDQLPKSICKSI----CQHLflpvVEKVYLFKGVSREILLLLVTKMKAEYIPPREDVIMQNEAPDDVYIVVSGEVEI 428
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686413 513 I----TKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVleeypMMRRAFETVAIdrldrigKKN 588
Cdd:PLN03192 429 IdsegEKERVVGTLGCGDIFGEVGALCCRPQSFTFRTKTLSQLLRLKTSTLIEA-----MQTRQEDNVVI-------LKN 496
                        490       500
                 ....*....|....*....|..
gi 148686413 589 SILLQKFQKDLNTGVFNNQENE 610
Cdd:PLN03192 497 FLQHHKELHDLNVGDLLGDNGG 518
 
Name Accession Description Interval E-value
CAP_ED cd00038
effector domain of the CAP family of transcription factors; members include CAP (or cAMP ...
465-573 5.66e-28

effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels


Pssm-ID: 237999 [Multi-domain]  Cd Length: 115  Bit Score: 108.95  E-value: 5.66e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686413 465 LFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSS--KEMK---LTDGSYFGEICLLTKGRR 539
Cdd:cd00038    1 LFSGLDDEELEELADALEERRFPAGEVIIRQGDPADSLYIVLSGSVEVYKLDEdgREQIvgfLGPGDLFGELALLGNGPR 80
                         90       100       110
                 ....*....|....*....|....*....|....
gi 148686413 540 TASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAF 573
Cdd:cd00038   81 SATVRALTDSELLVLPRSDFRRLLQEYPELARRL 114
Ion_trans_N pfam08412
Ion transport protein N-terminal; This metazoan domain is found to the N-terminus of pfam00520 ...
88-130 8.53e-22

Ion transport protein N-terminal; This metazoan domain is found to the N-terminus of pfam00520 in voltage- and cyclic nucleotide-gated K/Na ion channels.


Pssm-ID: 400630  Cd Length: 43  Bit Score: 88.90  E-value: 8.53e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 148686413   88 FTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSD 130
Cdd:pfam08412   1 LKSLLQPSDNKLSMKLFGSKKAVEKEKERQKEAGVWIIHPCSN 43
cNMP smart00100
Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a ...
465-574 1.26e-20

Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a prokaryotic homologue of eukaryotic cNMP-binding domains, present in ion channels, and cNMP-dependent kinases.


Pssm-ID: 197516 [Multi-domain]  Cd Length: 120  Bit Score: 88.23  E-value: 1.26e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686413   465 LFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGV--ITKSSKEM---KLTDGSYFGEICLLTKGRR 539
Cdd:smart00100   1 LFKNLDAEELRELADALEPVRYPAGEVIIRQGDVGDSFYIIVSGEVEVykVLEDGEEQivgTLGPGDFFGELALLTNSRR 80
                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 148686413   540 TASVRADTY--CRLYSLSVDNFNEVLEEYPMMRRAFE 574
Cdd:smart00100  81 AASAAAVALelATLLRIDFRDFLQLLPELPQLLLELL 117
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
123-610 9.71e-20

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 94.93  E-value: 9.71e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686413 123 WIIHPYsDFRF-YWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFRTGTVNEDSSEIILDPK 201
Cdd:PLN03192  52 WIISPM-DSRYrWWETLMVVLVAYSAWVYPFEVAFLNASPKRGLEIADNVVDLFFAVDIVLTFFVAYIDPRTQLLVRDRK 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686413 202 VIKMNYLKSWFVVDFISSIPVDYI-FLIVEKGMDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIhqWeeifhmtyd 280
Cdd:PLN03192 131 KIAVRYLSTWFLMDVASTIPFQALaYLITGTVKLNLSYSLLGLLRFWRLRRVKQLFTRLEKDIRFSYF--W--------- 199
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686413 281 lasavVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVS--LNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVS 358
Cdd:PLN03192 200 -----IRCARLLSVTLFLVHCAGCLYYLIADRYPHQGKTWIGavIPNFRETSLWIRYISAIYWSITTMTTVGYGDLHAVN 274
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686413 359 MSDLWITMLSMIVGATCYAMFVGHATALIqsLDSSRR--QYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDE 436
Cdd:PLN03192 275 TIEMIFIIFYMLFNLGLTAYLIGNMTNLV--VEGTRRtmEFRNSIEAASNFVGRNRLPPRLKDQILAYMCLRFKAESLNQ 352
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686413 437 ENILSELNDPLREEIvnfnCRKL----VATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGV 512
Cdd:PLN03192 353 QQLIDQLPKSICKSI----CQHLflpvVEKVYLFKGVSREILLLLVTKMKAEYIPPREDVIMQNEAPDDVYIVVSGEVEI 428
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686413 513 I----TKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVleeypMMRRAFETVAIdrldrigKKN 588
Cdd:PLN03192 429 IdsegEKERVVGTLGCGDIFGEVGALCCRPQSFTFRTKTLSQLLRLKTSTLIEA-----MQTRQEDNVVI-------LKN 496
                        490       500
                 ....*....|....*....|..
gi 148686413 589 SILLQKFQKDLNTGVFNNQENE 610
Cdd:PLN03192 497 FLQHHKELHDLNVGDLLGDNGG 518
Crp COG0664
cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal ...
466-594 1.25e-18

cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms];


Pssm-ID: 440428 [Multi-domain]  Cd Length: 207  Bit Score: 85.42  E-value: 1.25e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686413 466 FANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSS--KEMKL---TDGSYFGEICLLTKGRRT 540
Cdd:COG0664    1 FAGLSDEELEALLAHLELRTLKKGEVLFREGDPADHLYFVLSGLVKLYRISEdgREQILgflGPGDFFGELSLLGGEPSP 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 148686413 541 ASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQK 594
Cdd:COG0664   81 ATAEALEDSELLRIPREDLEELLERNPELARALLRLLARRLRQLQERLVSLAFL 134
cNMP_binding pfam00027
Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, ...
483-566 8.77e-18

Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, oxygen and 2-oxoglutarate (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 459637 [Multi-domain]  Cd Length: 89  Bit Score: 78.81  E-value: 8.77e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686413  483 FEVFQPGDYIIREGAVGKKMYFIQHGVAGV--ITKSSKEMK---LTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVD 557
Cdd:pfam00027   1 LRSYKAGEVIFREGDPADSLYIVLSGKVKVyrTLEDGREQIlavLGPGDFFGELALLGGEPRSATVVALTDSELLVIPRE 80

                  ....*....
gi 148686413  558 NFNEVLEEY 566
Cdd:pfam00027  81 DFLELLERD 89
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
132-395 3.64e-17

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 81.93  E-value: 3.64e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686413  132 RFYWDLIMLIMMVGNLVIIPVGITF-FTEQTTTPWIIFNVASDTVFLLDLIMNFRTGTvnedsseiildpkvIKMNYLKS 210
Cdd:pfam00520   1 SRYFELFILLLILLNTIFLALETYFqPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAG--------------FKKRYFRS 66
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686413  211 -WFVVDFISSIPVDYIFLIVEKGMDSEVyktaRALRIVRFtkilsllrllrlSRLIRYIHQWEEIFHMTYdlasAVVRIF 289
Cdd:pfam00520  67 pWNILDFVVVLPSLISLVLSSVGSLSGL----RVLRLLRL------------LRLLRLIRRLEGLRTLVN----SLIRSL 126
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686413  290 NLIGMMLLLCHWDGCLQFLVpLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSD-------L 362
Cdd:pfam00520 127 KSLGNLLLLLLLFLFIFAII-GYQLFGGKLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGkgefwayI 205
                         250       260       270
                  ....*....|....*....|....*....|...
gi 148686413  363 WITMLSMIVGATCYAMFVGHATALIQSLDSSRR 395
Cdd:pfam00520 206 YFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
PRK11753 PRK11753
cAMP-activated global transcriptional regulator CRP;
492-567 2.69e-07

cAMP-activated global transcriptional regulator CRP;


Pssm-ID: 236969 [Multi-domain]  Cd Length: 211  Bit Score: 52.29  E-value: 2.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686413 492 IIREGAVGKKMYFIQHGVAGVITKSS--KEMKLT---DGSYFGEICLLTKG-RRTASVRADTYCRLYSLSVDNFNEVLEE 565
Cdd:PRK11753  31 LIHAGEKAETLYYIVKGSVAVLIKDEegKEMILSylnQGDFIGELGLFEEGqERSAWVRAKTACEVAEISYKKFRQLIQV 110

                 ..
gi 148686413 566 YP 567
Cdd:PRK11753 111 NP 112
 
Name Accession Description Interval E-value
CAP_ED cd00038
effector domain of the CAP family of transcription factors; members include CAP (or cAMP ...
465-573 5.66e-28

effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels


Pssm-ID: 237999 [Multi-domain]  Cd Length: 115  Bit Score: 108.95  E-value: 5.66e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686413 465 LFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSS--KEMK---LTDGSYFGEICLLTKGRR 539
Cdd:cd00038    1 LFSGLDDEELEELADALEERRFPAGEVIIRQGDPADSLYIVLSGSVEVYKLDEdgREQIvgfLGPGDLFGELALLGNGPR 80
                         90       100       110
                 ....*....|....*....|....*....|....
gi 148686413 540 TASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAF 573
Cdd:cd00038   81 SATVRALTDSELLVLPRSDFRRLLQEYPELARRL 114
Ion_trans_N pfam08412
Ion transport protein N-terminal; This metazoan domain is found to the N-terminus of pfam00520 ...
88-130 8.53e-22

Ion transport protein N-terminal; This metazoan domain is found to the N-terminus of pfam00520 in voltage- and cyclic nucleotide-gated K/Na ion channels.


Pssm-ID: 400630  Cd Length: 43  Bit Score: 88.90  E-value: 8.53e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 148686413   88 FTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSD 130
Cdd:pfam08412   1 LKSLLQPSDNKLSMKLFGSKKAVEKEKERQKEAGVWIIHPCSN 43
cNMP smart00100
Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a ...
465-574 1.26e-20

Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a prokaryotic homologue of eukaryotic cNMP-binding domains, present in ion channels, and cNMP-dependent kinases.


Pssm-ID: 197516 [Multi-domain]  Cd Length: 120  Bit Score: 88.23  E-value: 1.26e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686413   465 LFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGV--ITKSSKEM---KLTDGSYFGEICLLTKGRR 539
Cdd:smart00100   1 LFKNLDAEELRELADALEPVRYPAGEVIIRQGDVGDSFYIIVSGEVEVykVLEDGEEQivgTLGPGDFFGELALLTNSRR 80
                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 148686413   540 TASVRADTY--CRLYSLSVDNFNEVLEEYPMMRRAFE 574
Cdd:smart00100  81 AASAAAVALelATLLRIDFRDFLQLLPELPQLLLELL 117
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
123-610 9.71e-20

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 94.93  E-value: 9.71e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686413 123 WIIHPYsDFRF-YWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFRTGTVNEDSSEIILDPK 201
Cdd:PLN03192  52 WIISPM-DSRYrWWETLMVVLVAYSAWVYPFEVAFLNASPKRGLEIADNVVDLFFAVDIVLTFFVAYIDPRTQLLVRDRK 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686413 202 VIKMNYLKSWFVVDFISSIPVDYI-FLIVEKGMDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIhqWeeifhmtyd 280
Cdd:PLN03192 131 KIAVRYLSTWFLMDVASTIPFQALaYLITGTVKLNLSYSLLGLLRFWRLRRVKQLFTRLEKDIRFSYF--W--------- 199
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686413 281 lasavVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVS--LNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVS 358
Cdd:PLN03192 200 -----IRCARLLSVTLFLVHCAGCLYYLIADRYPHQGKTWIGavIPNFRETSLWIRYISAIYWSITTMTTVGYGDLHAVN 274
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686413 359 MSDLWITMLSMIVGATCYAMFVGHATALIqsLDSSRR--QYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDE 436
Cdd:PLN03192 275 TIEMIFIIFYMLFNLGLTAYLIGNMTNLV--VEGTRRtmEFRNSIEAASNFVGRNRLPPRLKDQILAYMCLRFKAESLNQ 352
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686413 437 ENILSELNDPLREEIvnfnCRKL----VATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGV 512
Cdd:PLN03192 353 QQLIDQLPKSICKSI----CQHLflpvVEKVYLFKGVSREILLLLVTKMKAEYIPPREDVIMQNEAPDDVYIVVSGEVEI 428
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686413 513 I----TKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVleeypMMRRAFETVAIdrldrigKKN 588
Cdd:PLN03192 429 IdsegEKERVVGTLGCGDIFGEVGALCCRPQSFTFRTKTLSQLLRLKTSTLIEA-----MQTRQEDNVVI-------LKN 496
                        490       500
                 ....*....|....*....|..
gi 148686413 589 SILLQKFQKDLNTGVFNNQENE 610
Cdd:PLN03192 497 FLQHHKELHDLNVGDLLGDNGG 518
Crp COG0664
cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal ...
466-594 1.25e-18

cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms];


Pssm-ID: 440428 [Multi-domain]  Cd Length: 207  Bit Score: 85.42  E-value: 1.25e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686413 466 FANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSS--KEMKL---TDGSYFGEICLLTKGRRT 540
Cdd:COG0664    1 FAGLSDEELEALLAHLELRTLKKGEVLFREGDPADHLYFVLSGLVKLYRISEdgREQILgflGPGDFFGELSLLGGEPSP 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 148686413 541 ASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQK 594
Cdd:COG0664   81 ATAEALEDSELLRIPREDLEELLERNPELARALLRLLARRLRQLQERLVSLAFL 134
cNMP_binding pfam00027
Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, ...
483-566 8.77e-18

Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, oxygen and 2-oxoglutarate (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 459637 [Multi-domain]  Cd Length: 89  Bit Score: 78.81  E-value: 8.77e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686413  483 FEVFQPGDYIIREGAVGKKMYFIQHGVAGV--ITKSSKEMK---LTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVD 557
Cdd:pfam00027   1 LRSYKAGEVIFREGDPADSLYIVLSGKVKVyrTLEDGREQIlavLGPGDFFGELALLGGEPRSATVVALTDSELLVIPRE 80

                  ....*....
gi 148686413  558 NFNEVLEEY 566
Cdd:pfam00027  81 DFLELLERD 89
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
132-395 3.64e-17

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 81.93  E-value: 3.64e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686413  132 RFYWDLIMLIMMVGNLVIIPVGITF-FTEQTTTPWIIFNVASDTVFLLDLIMNFRTGTvnedsseiildpkvIKMNYLKS 210
Cdd:pfam00520   1 SRYFELFILLLILLNTIFLALETYFqPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAG--------------FKKRYFRS 66
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686413  211 -WFVVDFISSIPVDYIFLIVEKGMDSEVyktaRALRIVRFtkilsllrllrlSRLIRYIHQWEEIFHMTYdlasAVVRIF 289
Cdd:pfam00520  67 pWNILDFVVVLPSLISLVLSSVGSLSGL----RVLRLLRL------------LRLLRLIRRLEGLRTLVN----SLIRSL 126
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686413  290 NLIGMMLLLCHWDGCLQFLVpLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSD-------L 362
Cdd:pfam00520 127 KSLGNLLLLLLLFLFIFAII-GYQLFGGKLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGkgefwayI 205
                         250       260       270
                  ....*....|....*....|....*....|...
gi 148686413  363 WITMLSMIVGATCYAMFVGHATALIQSLDSSRR 395
Cdd:pfam00520 206 YFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
PRK11753 PRK11753
cAMP-activated global transcriptional regulator CRP;
492-567 2.69e-07

cAMP-activated global transcriptional regulator CRP;


Pssm-ID: 236969 [Multi-domain]  Cd Length: 211  Bit Score: 52.29  E-value: 2.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686413 492 IIREGAVGKKMYFIQHGVAGVITKSS--KEMKLT---DGSYFGEICLLTKG-RRTASVRADTYCRLYSLSVDNFNEVLEE 565
Cdd:PRK11753  31 LIHAGEKAETLYYIVKGSVAVLIKDEegKEMILSylnQGDFIGELGLFEEGqERSAWVRAKTACEVAEISYKKFRQLIQV 110

                 ..
gi 148686413 566 YP 567
Cdd:PRK11753 111 NP 112
PLN02868 PLN02868
acyl-CoA thioesterase family protein
481-529 3.35e-03

acyl-CoA thioesterase family protein


Pssm-ID: 178459 [Multi-domain]  Cd Length: 413  Bit Score: 40.86  E-value: 3.35e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 148686413 481 LRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITK----SSKEMKLTDGSYFG 529
Cdd:PLN02868  31 VVPKRYGKGEYVVREGEPGDGLYFIWKGEAEVSGPaeeeSRPEFLLKRYDYFG 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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