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Conserved domains on  [gi|148690698|gb|EDL22645|]
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zinc finger protein 715, isoform CRA_c, partial [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
27-84 4.56e-26

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 101.52  E-value: 4.56e-26
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 148690698    27 MSFEDVTVNFSQEEWQHLDSAQRCLYQEVMLEIYSHLLAVGYSIPSPGVIFRMEKGKE 84
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEE 58
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
389-828 3.96e-14

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.89  E-value: 3.96e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690698 389 TPFICDICGKAFLRKSELTSHKQCHNGEKPYKCND--CEKSFKFPSQLKVHHQIHTGEKPYECR-ECGKSFSKTAKLKVH 465
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690698 466 QRIHTGEKPYVCSQCGKAFNQKSILDRHEKLHPGEKPYKCNDCGKS-------FNYPSQLKVHCHSHTgekPYKCHECGK 538
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSsvntpqsNSLHPPLPANSLSKD---PSSNLSLLI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690698 539 SFNFPCELKVHYQNHTGEKPYKcrecwklfskmsqLKAHYRVHTGERPYKCSHCGKAFSTKEQVQEHERIHTGEKPFVCT 618
Cdd:COG5048  189 SSNVSTSIPSSSENSPLSSSYS-------------IPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSS 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690698 619 ECGKAFSSRSSFRKHQLIHTKEKPFVSQKCETglqeatliphqqlhigeKPYKCPDCGKLFNYPSQLKSHYQ--IHTGE- 695
Cdd:COG5048  256 SASESPRSSLPTASSQSSSPNESDSSSEKGFS-----------------LPIKSKQCNISFSRSSPLTRHLRsvNHSGEs 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690698 696 -KPCKCP--DCGKSFSKTSQLKAHSRIHTGERPYVC--SVCGKAFKQLSTLSRHEKIHM-----VEKPYKC--SFCGKSF 763
Cdd:COG5048  319 lKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQykdlkNDKKSETlsNSCIRNF 398

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 148690698 764 CSPSELKVHLLIHTGERP--YKCSSCWKAFCTKVQLQEHERIHTgERPYVCTHCGKAFRSRSVFSKH 828
Cdd:COG5048  399 KRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNH 464
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
27-84 4.56e-26

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 101.52  E-value: 4.56e-26
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 148690698    27 MSFEDVTVNFSQEEWQHLDSAQRCLYQEVMLEIYSHLLAVGYSIPSPGVIFRMEKGKE 84
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEE 58
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 27-67 2.50e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.75  E-value: 2.50e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 148690698   27 MSFEDVTVNFSQEEWQHLDSAQRCLYQEVMLEIYSHLLAVG 67
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 27-63 2.98e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 70.27  E-value: 2.98e-15
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 148690698  27 MSFEDVTVNFSQEEWQHLDSAQRCLYQEVMLEIYSHL 63
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
389-828 3.96e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.89  E-value: 3.96e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690698 389 TPFICDICGKAFLRKSELTSHKQCHNGEKPYKCND--CEKSFKFPSQLKVHHQIHTGEKPYECR-ECGKSFSKTAKLKVH 465
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690698 466 QRIHTGEKPYVCSQCGKAFNQKSILDRHEKLHPGEKPYKCNDCGKS-------FNYPSQLKVHCHSHTgekPYKCHECGK 538
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSsvntpqsNSLHPPLPANSLSKD---PSSNLSLLI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690698 539 SFNFPCELKVHYQNHTGEKPYKcrecwklfskmsqLKAHYRVHTGERPYKCSHCGKAFSTKEQVQEHERIHTGEKPFVCT 618
Cdd:COG5048  189 SSNVSTSIPSSSENSPLSSSYS-------------IPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSS 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690698 619 ECGKAFSSRSSFRKHQLIHTKEKPFVSQKCETglqeatliphqqlhigeKPYKCPDCGKLFNYPSQLKSHYQ--IHTGE- 695
Cdd:COG5048  256 SASESPRSSLPTASSQSSSPNESDSSSEKGFS-----------------LPIKSKQCNISFSRSSPLTRHLRsvNHSGEs 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690698 696 -KPCKCP--DCGKSFSKTSQLKAHSRIHTGERPYVC--SVCGKAFKQLSTLSRHEKIHM-----VEKPYKC--SFCGKSF 763
Cdd:COG5048  319 lKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQykdlkNDKKSETlsNSCIRNF 398

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 148690698 764 CSPSELKVHLLIHTGERP--YKCSSCWKAFCTKVQLQEHERIHTgERPYVCTHCGKAFRSRSVFSKH 828
Cdd:COG5048  399 KRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
462-486 1.82e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.82e-04
                          10        20
                  ....*....|....*....|....*
gi 148690698  462 LKVHQRIHTGEKPYVCSQCGKAFNQ 486
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
27-84 4.56e-26

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 101.52  E-value: 4.56e-26
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 148690698    27 MSFEDVTVNFSQEEWQHLDSAQRCLYQEVMLEIYSHLLAVGYSIPSPGVIFRMEKGKE 84
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEE 58
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 27-67 2.50e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.75  E-value: 2.50e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 148690698   27 MSFEDVTVNFSQEEWQHLDSAQRCLYQEVMLEIYSHLLAVG 67
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 27-63 2.98e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 70.27  E-value: 2.98e-15
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 148690698  27 MSFEDVTVNFSQEEWQHLDSAQRCLYQEVMLEIYSHL 63
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
389-828 3.96e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.89  E-value: 3.96e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690698 389 TPFICDICGKAFLRKSELTSHKQCHNGEKPYKCND--CEKSFKFPSQLKVHHQIHTGEKPYECR-ECGKSFSKTAKLKVH 465
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690698 466 QRIHTGEKPYVCSQCGKAFNQKSILDRHEKLHPGEKPYKCNDCGKS-------FNYPSQLKVHCHSHTgekPYKCHECGK 538
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSsvntpqsNSLHPPLPANSLSKD---PSSNLSLLI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690698 539 SFNFPCELKVHYQNHTGEKPYKcrecwklfskmsqLKAHYRVHTGERPYKCSHCGKAFSTKEQVQEHERIHTGEKPFVCT 618
Cdd:COG5048  189 SSNVSTSIPSSSENSPLSSSYS-------------IPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSS 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690698 619 ECGKAFSSRSSFRKHQLIHTKEKPFVSQKCETglqeatliphqqlhigeKPYKCPDCGKLFNYPSQLKSHYQ--IHTGE- 695
Cdd:COG5048  256 SASESPRSSLPTASSQSSSPNESDSSSEKGFS-----------------LPIKSKQCNISFSRSSPLTRHLRsvNHSGEs 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690698 696 -KPCKCP--DCGKSFSKTSQLKAHSRIHTGERPYVC--SVCGKAFKQLSTLSRHEKIHM-----VEKPYKC--SFCGKSF 763
Cdd:COG5048  319 lKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQykdlkNDKKSETlsNSCIRNF 398

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 148690698 764 CSPSELKVHLLIHTGERP--YKCSSCWKAFCTKVQLQEHERIHTgERPYVCTHCGKAFRSRSVFSKH 828
Cdd:COG5048  399 KRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
333-745 3.15e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.81  E-value: 3.15e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690698 333 DPYKCSSCEKSFCNAAALQQHEQIHTEEKLYVCTL--CGKAFSDGSAFYEHELIHKNHTPFICDICG---KAFLRKSELT 407
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLplsNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690698 408 SHkqCHNGEKPYKCNDCEKSFKFPSQLKVHHQIHTGEKPYECRECGKSFSKTaklKVHQRIHtGEKPYVCSQCGKAFNQK 487
Cdd:COG5048  112 SS--SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNT---PQSNSLH-PPLPANSLSKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690698 488 SILdrHEKLHPGEKPYKCNDCGKSFNYPSQLKVHCHSHTGEKPYKCHECgkSFNFPCELKVHYQNHTGEKPYKCRECWKL 567
Cdd:COG5048  186 LLI--SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSLSSSDSSSSASESP 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690698 568 FS----KMSQLKAHYRVHTGER-----PYKCSHCGKAFSTKEQVQEHER--IHTGE--KPFVCTE--CGKAFSSRSSFRK 632
Cdd:COG5048  262 RSslptASSQSSSPNESDSSSEkgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKR 341

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690698 633 HQLIHTKEKPF---------VSQKCETGLQEATLIPHQQLHIgEKPYKCPDCGKLFNYPSQ--LKSHYQIHTGEKP--CK 699
Cdd:COG5048  342 HILLHTSISPAkekllnsssKFSPLLNNEPPQSLQQYKDLKN-DKKSETLSNSCIRNFKRDsnLSLHIITHLSFRPynCK 420

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*.
gi 148690698 700 CPDCGKSFSKTSQLKAHSRIHTGERPYVCSVCGKAFKQLSTLSRHE 745
Cdd:COG5048  421 NPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 665-746 1.35e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.48  E-value: 1.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690698 665 IGEKPYKCP--DCGKLFNYPSQLKSH-YQIHTGEKPCKCPDCGKsfsktsqlkaHSRIHTGERPYVCSVCGKAFKQLSTL 741
Cdd:COG5189  345 KDGKPYKCPveGCNKKYKNQNGLKYHmLHGHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGL 414


                 ....*
gi 148690698 742 SRHEK 746
Cdd:COG5189  415 KYHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
462-486 1.82e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.82e-04
                          10        20
                  ....*....|....*....|....*
gi 148690698  462 LKVHQRIHTGEKPYVCSQCGKAFNQ 486
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
741-763 4.28e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 4.28e-04
                          10        20
                  ....*....|....*....|...
gi 148690698  741 LSRHEKIHMVEKPYKCSFCGKSF 763
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
797-821 4.45e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 4.45e-04
                          10        20
                  ....*....|....*....|....*
gi 148690698  797 LQEHERIHTGERPYVCTHCGKAFRS 821
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
713-737 5.91e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.91e-04
                          10        20
                  ....*....|....*....|....*
gi 148690698  713 LKAHSRIHTGERPYVCSVCGKAFKQ 737
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
603-626 6.21e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 6.21e-04
                          10        20
                  ....*....|....*....|....
gi 148690698  603 QEHERIHTGEKPFVCTECGKAFSS 626
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
490-514 6.46e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 6.46e-04
                          10        20
                  ....*....|....*....|....*
gi 148690698  490 LDRHEKLHPGEKPYKCNDCGKSFNY 514
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
518-541 8.10e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 8.10e-04
                          10        20
                  ....*....|....*....|....
gi 148690698  518 LKVHCHSHTGEKPYKCHECGKSFN 541
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
585-865 9.48e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 9.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690698 585 RPYKCSHCGKAFSTKEQVQEHERIHTGEKPFVCT--ECGKAFSSRSSFRKHQLIHTKEKPFVSQKCETGLQEATL--IPH 660
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASssSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690698 661 QQLHIGEKPYKCPDCGKLFNYPSQLKSHYQIHTGEKPCKCPDCGKSFSKTSQ----------------------LKAHSR 718
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQsnslhpplpanslskdpssnlsLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690698 719 IHTGERPYVCSVCGKAFKQLSTLSRHEKIHMVEKPYKCSFCGKSF------CSPSELKVHLLIHTGERPYKCSSCWKAFC 792
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690698 793 TKVQLQEHERIHTGER-PYVCTHCGKAFRSRSVFSKHK--LIHRKE--TPFIC--ERCGKVFLQKSELTSHLQTHIEDKP 865
Cdd:COG5048  272 SSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351
zf-H2C2_2 pfam13465
Zinc-finger double domain;
574-598 1.26e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.26e-03
                          10        20
                  ....*....|....*....|....*
gi 148690698  574 LKAHYRVHTGERPYKCSHCGKAFST 598
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
434-458 1.55e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.55e-03
                          10        20
                  ....*....|....*....|....*
gi 148690698  434 LKVHHQIHTGEKPYECRECGKSFSK 458
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 611-688 2.39e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 2.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690698 611 GEKPFVC--TECGKAFSSRSSFRKHQLiHTKEKPFVSQKCETglqeatlIPHQQLHIGEKPYKCPDCGKLFNYPSQLKSH 688
Cdd:COG5189  346 DGKPYKCpvEGCNKKYKNQNGLKYHML-HGHQNQKLHENPSP-------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 695-772 3.52e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 3.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690698 695 EKPCKCPDCGKSFSKTSQLKAH---SRIHT-GERPYVCSV--CGKAFKQLSTLSRHEK-------------------IHM 749
Cdd:COG5189  315 KLPCTNSSSNGKLAHGGERNIDtpsRMLKVkDGKPYKCPVegCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSA 394

                         90       100
                 ....*....|....*....|...
gi 148690698 750 VEKPYKCSFCGKSFCSPSELKVH 772
Cdd:COG5189  395 KDKPYRCEVCDKRYKNLNGLKYH 417
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 372-525 3.52e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 3.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690698 372 FSDGSAFYEHELIHKNHTpfICDICGkAFLRKSELTSHKQCHNGEK--PYKCNDCEKSFKFPSQLkvhhQIHTGEKPYEC 449
Cdd:COG5189  280 FEESSLGFDYEFIHKSVG--NKEIRG-GISTGEMIDVRKLPCTNSSsnGKLAHGGERNIDTPSRM----LKVKDGKPYKC 352

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 148690698 450 R--ECGKSFSKTAKLKVHqRIHtgekpyvcSQCGKAFNQKSILDRHEKLHPGEKPYKCNDCGKSFNYPSQLKVH-CHSH 525
Cdd:COG5189  353 PveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHrKHSH 422
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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