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Conserved domains on  [gi|149015574|gb|EDL74955|]
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similar to hypothetical protein LOC199675 (predicted) [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lectin_N super family cl04343
Hepatic lectin, N-terminal domain; This is the N-terminal domain found in hepatic lectins, ...
 66-146 3.06e-03

Hepatic lectin, N-terminal domain; This is the N-terminal domain found in hepatic lectins, also known as Asialoglycoprotein receptors (ASGRs). ASGRs function as scavengers to mediate the endocytosis of plasma glycoproteins with terminal galactose and N-acetylgalactosamine units. ASGR is composed of a major (ASGR1) and a minor (ASGR2) subunits, both of which are type II, single-pass transmembrane proteins. ASGR is highly expressed in liver but has been also identified in human peripheral blood monocytes, representing a mobile pool of the receptor reaching distant sites from the liver to play a scavenger function where there is an infection or a damaged tissue. This domain includes the short, single transmembrane domain and the stalk region which mediates the oligomerization between subunits.


The actual alignment was detected with superfamily member pfam03954:

Pssm-ID: 461106  Cd Length: 140  Bit Score: 36.53  E-value: 3.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149015574   66 PWLHRSIMMLYVLLALVFLFCIILSalalvKNFQMSKELWTLKEELSNV-SNTVWNIQTLQNQQKSiweaVQRDIREAKS 144
Cdd:pfam03954  33 SGLRLLLLSLGLSLLLLVVVCVIGS-----QNSQLQRELLTLKETFSNFsSSTEAEVQALHSQGGS----LGDKVTSLES 103


                  ..
gi 149015574  145 SL 146
Cdd:pfam03954 104 KL 105
 
Name Accession Description Interval E-value
Lectin_N pfam03954
Hepatic lectin, N-terminal domain; This is the N-terminal domain found in hepatic lectins, ...
 66-146 3.06e-03

Hepatic lectin, N-terminal domain; This is the N-terminal domain found in hepatic lectins, also known as Asialoglycoprotein receptors (ASGRs). ASGRs function as scavengers to mediate the endocytosis of plasma glycoproteins with terminal galactose and N-acetylgalactosamine units. ASGR is composed of a major (ASGR1) and a minor (ASGR2) subunits, both of which are type II, single-pass transmembrane proteins. ASGR is highly expressed in liver but has been also identified in human peripheral blood monocytes, representing a mobile pool of the receptor reaching distant sites from the liver to play a scavenger function where there is an infection or a damaged tissue. This domain includes the short, single transmembrane domain and the stalk region which mediates the oligomerization between subunits.


Pssm-ID: 461106  Cd Length: 140  Bit Score: 36.53  E-value: 3.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149015574   66 PWLHRSIMMLYVLLALVFLFCIILSalalvKNFQMSKELWTLKEELSNV-SNTVWNIQTLQNQQKSiweaVQRDIREAKS 144
Cdd:pfam03954  33 SGLRLLLLSLGLSLLLLVVVCVIGS-----QNSQLQRELLTLKETFSNFsSSTEAEVQALHSQGGS----LGDKVTSLES 103


                  ..
gi 149015574  145 SL 146
Cdd:pfam03954 104 KL 105
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 73-182 4.83e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 36.67  E-value: 4.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149015574  73 MMLYVLLALVFLFCIILSALALVKNfqmSKELWTLKEELSNVSNTVWNIQTLQNQQKSIWEAVQRDIREAKSSLGTVKSS 152
Cdd:COG4942    1 MRKLLLLALLLALAAAAQADAAAEA---EAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQE 77

                         90       100       110
                 ....*....|....*....|....*....|
gi 149015574 153 IQTGNDRLKTVPEDITQIKKTLEALEKKIQ 182
Cdd:COG4942   78 LAALEAELAELEKEIAELRAELEAQKEELA 107
 
Name Accession Description Interval E-value
Lectin_N pfam03954
Hepatic lectin, N-terminal domain; This is the N-terminal domain found in hepatic lectins, ...
 66-146 3.06e-03

Hepatic lectin, N-terminal domain; This is the N-terminal domain found in hepatic lectins, also known as Asialoglycoprotein receptors (ASGRs). ASGRs function as scavengers to mediate the endocytosis of plasma glycoproteins with terminal galactose and N-acetylgalactosamine units. ASGR is composed of a major (ASGR1) and a minor (ASGR2) subunits, both of which are type II, single-pass transmembrane proteins. ASGR is highly expressed in liver but has been also identified in human peripheral blood monocytes, representing a mobile pool of the receptor reaching distant sites from the liver to play a scavenger function where there is an infection or a damaged tissue. This domain includes the short, single transmembrane domain and the stalk region which mediates the oligomerization between subunits.


Pssm-ID: 461106  Cd Length: 140  Bit Score: 36.53  E-value: 3.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149015574   66 PWLHRSIMMLYVLLALVFLFCIILSalalvKNFQMSKELWTLKEELSNV-SNTVWNIQTLQNQQKSiweaVQRDIREAKS 144
Cdd:pfam03954  33 SGLRLLLLSLGLSLLLLVVVCVIGS-----QNSQLQRELLTLKETFSNFsSSTEAEVQALHSQGGS----LGDKVTSLES 103


                  ..
gi 149015574  145 SL 146
Cdd:pfam03954 104 KL 105
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 73-182 4.83e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 36.67  E-value: 4.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149015574  73 MMLYVLLALVFLFCIILSALALVKNfqmSKELWTLKEELSNVSNTVWNIQTLQNQQKSIWEAVQRDIREAKSSLGTVKSS 152
Cdd:COG4942    1 MRKLLLLALLLALAAAAQADAAAEA---EAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQE 77

                         90       100       110
                 ....*....|....*....|....*....|
gi 149015574 153 IQTGNDRLKTVPEDITQIKKTLEALEKKIQ 182
Cdd:COG4942   78 LAALEAELAELEKEIAELRAELEAQKEELA 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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