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Conserved domains on  [gi|149021410|gb|EDL78873|]
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similar to low density lipoprotein receptor-related protein binding protein (predicted), isoform CRA_d [Rattus norvegicus]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 12120816)

ankyrin repeat (ANK) domain-containing protein mediates specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

CATH:  1.25.40.20
Gene Ontology:  GO:0005515
PubMed:  33435370|15152081|17176038
SCOP:  4000366

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
ANKYR super family cl34000
Ankyrin repeat [Signal transduction mechanisms];
10-85 4.26e-10

Ankyrin repeat [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG0666:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 54.19  E-value: 4.26e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 149021410  10 EDGLKNLLETGASVNAPpDPQEQSPVHLAAGGGLACFLLWQLQTGADLNQQDVLGETPLHKAAKVGSLECLSLLVA 85
Cdd:COG0666  100 LEIVKLLLEAGADVNAR-DKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLE 174
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
10-85 4.26e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 54.19  E-value: 4.26e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 149021410  10 EDGLKNLLETGASVNAPpDPQEQSPVHLAAGGGLACFLLWQLQTGADLNQQDVLGETPLHKAAKVGSLECLSLLVA 85
Cdd:COG0666  100 LEIVKLLLEAGADVNAR-DKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLE 174
Ank_2 pfam12796
Ankyrin repeats (3 copies);
36-85 1.03e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.80  E-value: 1.03e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 149021410  36 HLAAGGGLACFLLWQLQTGADLNQQDVLGETPLHKAAKVGSLECLSLLVA 85
Cdd:pfam12796  2 HLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE 51
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 13-84 1.70e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 44.18  E-value: 1.70e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 149021410  13 LKNLLETGASVNAPpDPQEQSPVHLAAGGGLACFLLWQLQTGADLNQQDVLGETPLHKAAKVGSLECLSLLV 84
Cdd:PHA02874 140 IKMLFEYGADVNIE-DDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLI 210
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 64-91 8.62e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 31.02  E-value: 8.62e-03
                          10        20
                  ....*....|....*....|....*...
gi 149021410   64 GETPLHKAAKVGSLECLSLLVASDVRIE 91
Cdd:smart00248  2 GRTPLHLAAENGNLEVVKLLLDKGADIN 29
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
10-85 4.26e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 54.19  E-value: 4.26e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 149021410  10 EDGLKNLLETGASVNAPpDPQEQSPVHLAAGGGLACFLLWQLQTGADLNQQDVLGETPLHKAAKVGSLECLSLLVA 85
Cdd:COG0666  100 LEIVKLLLEAGADVNAR-DKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLE 174
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
13-85 2.94e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 51.88  E-value: 2.94e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 149021410  13 LKNLLETGASVNAPpDPQEQSPVHLAAGGGLACFLLWQLQTGADLNQQDVLGETPLHKAAKVGSLECLSLLVA 85
Cdd:COG0666  136 VKLLLEAGADVNAQ-DNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLE 207
Ank_2 pfam12796
Ankyrin repeats (3 copies);
36-85 1.03e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.80  E-value: 1.03e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 149021410  36 HLAAGGGLACFLLWQLQTGADLNQQDVLGETPLHKAAKVGSLECLSLLVA 85
Cdd:pfam12796  2 HLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE 51
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-85 1.83e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 49.57  E-value: 1.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149021410   1 MLLLSCNLEEDGLKNLLETGASVNAPPDPQEQSPVHLAAGGGLACFLLWQLQTGADLNQQDVLGETPLHKAAKVGSLECL 80
Cdd:COG0666   57 LLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIV 136


                 ....*
gi 149021410  81 SLLVA 85
Cdd:COG0666  137 KLLLE 141
Ank_2 pfam12796
Ankyrin repeats (3 copies);
11-90 6.27e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 43.18  E-value: 6.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149021410  11 DGLKNLLETGASVNAPpDPQEQSPVHLAAGGGLAcFLLWQLQTGADLNQQDvLGETPLHKAAKVGSLECLSLLVASDVRI 90
Cdd:pfam12796 11 ELVKLLLENGADANLQ-DKNGRTALHLAAKNGHL-EIVKLLLEHADVNLKD-NGRTALHYAARSGHLEIVKLLLEKGADI 87
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
16-85 1.11e-06

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 44.56  E-value: 1.11e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149021410  16 LLETGASVNAPpDPQEQSPVHLAAGGGLACFLLWQLQTGADLNQQDVLGETPLHKAAKVGSLECLSLLVA 85
Cdd:COG0666  172 LLEAGADVNAR-DNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLE 240
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 13-84 1.70e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 44.18  E-value: 1.70e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 149021410  13 LKNLLETGASVNAPpDPQEQSPVHLAAGGGLACFLLWQLQTGADLNQQDVLGETPLHKAAKVGSLECLSLLV 84
Cdd:PHA02874 140 IKMLFEYGADVNIE-DDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLI 210
Ank_4 pfam13637
Ankyrin repeats (many copies);
33-84 1.74e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.11  E-value: 1.74e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 149021410  33 SPVHLAAGGGlaCFLLWQ--LQTGADLNQQDVLGETPLHKAAKVGSLECLSLLV 84
Cdd:pfam13637  3 TALHAAAASG--HLELLRllLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 13-84 1.90e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 38.32  E-value: 1.90e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 149021410  13 LKNLLETGASVNAPPDPQEQSPVHLAAGGGLACFLLwqLQTGADLNQQDVLGETPLHKAAKVGS-LECLSLLV 84
Cdd:PHA02878 251 LKLLLEHGVDVNAKSYILGLTALHSSIKSERKLKLL--LEYGADINSLNSYKLTPLSSAVKQYLcINIGRILI 321
PHA03095 PHA03095
ankyrin-like protein; Provisional
 15-68 4.84e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 36.93  E-value: 4.84e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 149021410  15 NLLETGASVNAPpDPQEQSPVHLAAGGGLACFLLWQLQTGADLNQQDVLGETPL 68
Cdd:PHA03095 242 PLLIAGISINAR-NRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPL 294
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 12-83 5.30e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 37.19  E-value: 5.30e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 149021410  12 GLKNLLETGASVNAPpDPQEQSPVHLAAGGGLACFLLWQLQTGADLNQQDVLGETPLHKAAKVGSLECLSLL 83
Cdd:PTZ00322  97 GARILLTGGADPNCR-DYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 51-90 5.82e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 36.97  E-value: 5.82e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 149021410  51 LQTGADLNQQDVLGETPLHKAAKVGSLECLSLLVA--SDVRI 90
Cdd:PHA02876 165 LEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSygADVNI 206
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 16-75 1.23e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 36.19  E-value: 1.23e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 149021410  16 LLETGASVNAPpDPQEQSPVHLAAGG-GLACFLLWQLQTGADLNQQDVLGETPLHKAAKVG 75
Cdd:PHA02876 259 LYDAGFSVNSI-DDCKNTPLHHASQApSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNG 318
PHA03095 PHA03095
ankyrin-like protein; Provisional
 2-69 1.53e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 35.77  E-value: 1.53e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 149021410   2 LLLSCNLEE--DGLKNLLETGASVNAPpDPQEQSPVHLaagggLACF--------LLwqLQTGADLNQQDVLGETPLH 69
Cdd:PHA03095  53 LYLHYSSEKvkDIVRLLLEAGADVNAP-ERCGFTPLHL-----YLYNattldvikLL--IKAGADVNAKDKVGRTPLH 122
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 7-83 3.77e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 34.47  E-value: 3.77e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 149021410   7 NLEEDGLKNLLETGASVNAPpDPQEQSPVHLAAGGGLACFLLWQLQTGADLNQQDVLGETPLHKAakVGSLECLSLL 83
Cdd:PHA02878 178 NKDQRLTELLLSYGANVNIP-DKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHIS--VGYCKDYDIL 251
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 64-91 8.62e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 31.02  E-value: 8.62e-03
                          10        20
                  ....*....|....*....|....*...
gi 149021410   64 GETPLHKAAKVGSLECLSLLVASDVRIE 91
Cdd:smart00248  2 GRTPLHLAAENGNLEVVKLLLDKGADIN 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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