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Conserved domains on  [gi|149026451|gb|EDL82601|]
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similar to cadherin 12, type 2 preproprotein (predicted) [Rattus norvegicus]

Protein Classification

cadherin( domain architecture ID 10638918)

cadherin is a glycoprotein involved in Ca2+-mediated cell-cell adhesion

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172
SCOP:  4007535

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 500-559 8.18e-34

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 122.26  E-value: 8.18e-34
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 149026451  500 NDADPAAPPYDSLATYAYEGNGSVAESLSSIDSLTSEADQDYDYLSDWGPRFKVLADMFG 559
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 49-156 4.91e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.70  E-value: 4.91e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149026451  49 IFHLKVPESSPVGSAIGRIRAVDPDFGKNAEIEYNIVPGDGGNLFDIvtdeDTQEGIIKLKKPLDFETKKAYTFKVEASN 128
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTATD 76

                         90       100
                 ....*....|....*....|....*...
gi 149026451 129 lhldhrfHSAGPFKDTATVKISVLDVDE 156
Cdd:cd11304   77 -------GGGPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 165-260 4.73e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.01  E-value: 4.73e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149026451 165 YTMEVYEDTPVGTIIGAVTAQDLDVGSSA-VRYFIDwKSDGDSYFTIDGTEGTIATNELLDRENTAQYNFSIIASKVSNP 243
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGeVTYSIV-SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                         90
                 ....*....|....*..
gi 149026451 244 SLTSKVNILINVLDVNE 260
Cdd:cd11304   81 PLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 268-366 1.41e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 58.09  E-value: 1.41e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149026451 268 PYETAVCENAKPGQIIQIVGAVDRDLSPAGqQFSFRLAPEAVIKPnFTVHdfrNNTAGIETRRNGySRRQQELYFLPIVI 347
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENG-EVTYSIVSGNEDGL-FSID---PSTGEITTAKPL-DREEQSSYTLTVTA 74

                         90
                 ....*....|....*....
gi 149026451 348 EDSSYPVQSSTNTMTIRVC 366
Cdd:cd11304   75 TDGGGPPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2-43 3.09e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 53.89  E-value: 3.09e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 149026451     2 DREVKEQYQVLIQAKDMGGQlgGLAGTTIVNITLTDVNDNPP 43
Cdd:smart00112  42 DREEQPEYTLTVEATDGGGP--PLSSTATVTITVLDVNDNAP 81
 
Name Accession Description Interval E-value
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 500-559 8.18e-34

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 122.26  E-value: 8.18e-34
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 149026451  500 NDADPAAPPYDSLATYAYEGNGSVAESLSSIDSLTSEADQDYDYLSDWGPRFKVLADMFG 559
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 49-156 4.91e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.70  E-value: 4.91e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149026451  49 IFHLKVPESSPVGSAIGRIRAVDPDFGKNAEIEYNIVPGDGGNLFDIvtdeDTQEGIIKLKKPLDFETKKAYTFKVEASN 128
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTATD 76

                         90       100
                 ....*....|....*....|....*...
gi 149026451 129 lhldhrfHSAGPFKDTATVKISVLDVDE 156
Cdd:cd11304   77 -------GGGPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 165-260 4.73e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.01  E-value: 4.73e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149026451 165 YTMEVYEDTPVGTIIGAVTAQDLDVGSSA-VRYFIDwKSDGDSYFTIDGTEGTIATNELLDRENTAQYNFSIIASKVSNP 243
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGeVTYSIV-SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                         90
                 ....*....|....*..
gi 149026451 244 SLTSKVNILINVLDVNE 260
Cdd:cd11304   81 PLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 68-158 1.25e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.78  E-value: 1.25e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149026451    68 RAVDPDFGKNAEIEYNIVPGDGGNLFDIvtdeDTQEGIIKLKKPLDFETKKAYTFKVEASNlhldhrfHSAGPFKDTATV 147
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSI----DPETGEITTTKPLDREEQPEYTLTVEATD-------GGGPPLSSTATV 69

                           90
                   ....*....|.
gi 149026451   148 KISVLDVDEPP 158
Cdd:smart00112  70 TITVLDVNDNA 80
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 183-263 3.99e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 76.23  E-value: 3.99e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149026451   183 TAQDLDVGSSA-VRYFIDwKSDGDSYFTIDGTEGTIATNELLDRENTAQYNFSIIASKVSNPSLTSKVNILINVLDVNEF 261
Cdd:smart00112   1 SATDADSGENGkVTYSIL-SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                   ..
gi 149026451   262 PP 263
Cdd:smart00112  80 AP 81
Cadherin pfam00028
Cadherin domain;
50-152 9.65e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.41  E-value: 9.65e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149026451   50 FHLKVPESSPVGSAIGRIRAVDPDFGKNAEIEYNIVPGDGGNLFDIvtdeDTQEGIIKLKKPLDFETKKAYTFKVEASNl 129
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRI----DPDTGDISTTKPLDRESIGEYELTVEATD- 75

                          90       100
                  ....*....|....*....|...
gi 149026451  130 hldhrfHSAGPFKDTATVKISVL 152
Cdd:pfam00028  76 ------SGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
165-256 9.60e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 72.72  E-value: 9.60e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149026451  165 YTMEVYEDTPVGTIIGAVTAQDLDVGS-SAVRYFIDwKSDGDSYFTIDGTEGTIATNELLDRENTAQYNFSIIASKVSNP 243
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPnGRIFYSIL-GGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                          90
                  ....*....|...
gi 149026451  244 SLTSKVNILINVL 256
Cdd:pfam00028  80 PLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 268-366 1.41e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 58.09  E-value: 1.41e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149026451 268 PYETAVCENAKPGQIIQIVGAVDRDLSPAGqQFSFRLAPEAVIKPnFTVHdfrNNTAGIETRRNGySRRQQELYFLPIVI 347
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENG-EVTYSIVSGNEDGL-FSID---PSTGEITTAKPL-DREEQSSYTLTVTA 74

                         90
                 ....*....|....*....
gi 149026451 348 EDSSYPVQSSTNTMTIRVC 366
Cdd:cd11304   75 TDGGGPPLSSTATVTITVL 93
Cadherin pfam00028
Cadherin domain;
269-366 9.91e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.38  E-value: 9.91e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149026451  269 YETAVCENAKPGQIIQIVGAVDRDLSPAGQQFSFRLAPEAviKPNFTVHdfrNNTAGIETRRNgYSRRQQELYFLPIVIE 348
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGP--GGNFRID---PDTGDISTTKP-LDRESIGEYELTVEAT 74

                          90
                  ....*....|....*...
gi 149026451  349 DSSYPVQSSTNTMTIRVC 366
Cdd:pfam00028  75 DSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2-43 3.09e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 53.89  E-value: 3.09e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 149026451     2 DREVKEQYQVLIQAKDMGGQlgGLAGTTIVNITLTDVNDNPP 43
Cdd:smart00112  42 DREEQPEYTLTVEATDGGGP--PLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1-41 2.13e-07

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 49.23  E-value: 2.13e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 149026451   1 MDREVKEQYQVLIQAKDMGGQlgGLAGTTIVNITLTDVNDN 41
Cdd:cd11304   60 LDREEQSSYTLTVTATDGGGP--PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 288-366 1.41e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 37.71  E-value: 1.41e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 149026451   288 AVDRDlSPAGQQFSFRLAPEAViKPNFTVHDfrnNTaGIETRRNGYSRRQQELYFLPIVIEDSSYPVQSSTNTMTIRVC 366
Cdd:smart00112   2 ATDAD-SGENGKVTYSILSGND-DGLFSIDP---ET-GEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
 
Name Accession Description Interval E-value
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 500-559 8.18e-34

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 122.26  E-value: 8.18e-34
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 149026451  500 NDADPAAPPYDSLATYAYEGNGSVAESLSSIDSLTSEADQDYDYLSDWGPRFKVLADMFG 559
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 49-156 4.91e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.70  E-value: 4.91e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149026451  49 IFHLKVPESSPVGSAIGRIRAVDPDFGKNAEIEYNIVPGDGGNLFDIvtdeDTQEGIIKLKKPLDFETKKAYTFKVEASN 128
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTATD 76

                         90       100
                 ....*....|....*....|....*...
gi 149026451 129 lhldhrfHSAGPFKDTATVKISVLDVDE 156
Cdd:cd11304   77 -------GGGPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 165-260 4.73e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.01  E-value: 4.73e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149026451 165 YTMEVYEDTPVGTIIGAVTAQDLDVGSSA-VRYFIDwKSDGDSYFTIDGTEGTIATNELLDRENTAQYNFSIIASKVSNP 243
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGeVTYSIV-SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                         90
                 ....*....|....*..
gi 149026451 244 SLTSKVNILINVLDVNE 260
Cdd:cd11304   81 PLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 68-158 1.25e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.78  E-value: 1.25e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149026451    68 RAVDPDFGKNAEIEYNIVPGDGGNLFDIvtdeDTQEGIIKLKKPLDFETKKAYTFKVEASNlhldhrfHSAGPFKDTATV 147
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSI----DPETGEITTTKPLDREEQPEYTLTVEATD-------GGGPPLSSTATV 69

                           90
                   ....*....|.
gi 149026451   148 KISVLDVDEPP 158
Cdd:smart00112  70 TITVLDVNDNA 80
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 183-263 3.99e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 76.23  E-value: 3.99e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149026451   183 TAQDLDVGSSA-VRYFIDwKSDGDSYFTIDGTEGTIATNELLDRENTAQYNFSIIASKVSNPSLTSKVNILINVLDVNEF 261
Cdd:smart00112   1 SATDADSGENGkVTYSIL-SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                   ..
gi 149026451   262 PP 263
Cdd:smart00112  80 AP 81
Cadherin pfam00028
Cadherin domain;
50-152 9.65e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.41  E-value: 9.65e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149026451   50 FHLKVPESSPVGSAIGRIRAVDPDFGKNAEIEYNIVPGDGGNLFDIvtdeDTQEGIIKLKKPLDFETKKAYTFKVEASNl 129
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRI----DPDTGDISTTKPLDRESIGEYELTVEATD- 75

                          90       100
                  ....*....|....*....|...
gi 149026451  130 hldhrfHSAGPFKDTATVKISVL 152
Cdd:pfam00028  76 ------SGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
165-256 9.60e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 72.72  E-value: 9.60e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149026451  165 YTMEVYEDTPVGTIIGAVTAQDLDVGS-SAVRYFIDwKSDGDSYFTIDGTEGTIATNELLDRENTAQYNFSIIASKVSNP 243
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPnGRIFYSIL-GGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                          90
                  ....*....|...
gi 149026451  244 SLTSKVNILINVL 256
Cdd:pfam00028  80 PLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 268-366 1.41e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 58.09  E-value: 1.41e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149026451 268 PYETAVCENAKPGQIIQIVGAVDRDLSPAGqQFSFRLAPEAVIKPnFTVHdfrNNTAGIETRRNGySRRQQELYFLPIVI 347
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENG-EVTYSIVSGNEDGL-FSID---PSTGEITTAKPL-DREEQSSYTLTVTA 74

                         90
                 ....*....|....*....
gi 149026451 348 EDSSYPVQSSTNTMTIRVC 366
Cdd:cd11304   75 TDGGGPPLSSTATVTITVL 93
Cadherin pfam00028
Cadherin domain;
269-366 9.91e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.38  E-value: 9.91e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149026451  269 YETAVCENAKPGQIIQIVGAVDRDLSPAGQQFSFRLAPEAviKPNFTVHdfrNNTAGIETRRNgYSRRQQELYFLPIVIE 348
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGP--GGNFRID---PDTGDISTTKP-LDRESIGEYELTVEAT 74

                          90
                  ....*....|....*...
gi 149026451  349 DSSYPVQSSTNTMTIRVC 366
Cdd:pfam00028  75 DSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2-43 3.09e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 53.89  E-value: 3.09e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 149026451     2 DREVKEQYQVLIQAKDMGGQlgGLAGTTIVNITLTDVNDNPP 43
Cdd:smart00112  42 DREEQPEYTLTVEATDGGGP--PLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1-41 2.13e-07

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 49.23  E-value: 2.13e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 149026451   1 MDREVKEQYQVLIQAKDMGGQlgGLAGTTIVNITLTDVNDN 41
Cdd:cd11304   60 LDREEQSSYTLTVTATDGGGP--PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 288-366 1.41e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 37.71  E-value: 1.41e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 149026451   288 AVDRDlSPAGQQFSFRLAPEAViKPNFTVHDfrnNTaGIETRRNGYSRRQQELYFLPIVIEDSSYPVQSSTNTMTIRVC 366
Cdd:smart00112   2 ATDAD-SGENGKVTYSILSGND-DGLFSIDP---ET-GEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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