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Conserved domains on  [gi|149036511|gb|EDL91129|]
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similar to D3Mm3e (predicted), isoform CRA_b [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1903264)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl43672
WD40 repeat [General function prediction only];
2-99 2.27e-07

WD40 repeat [General function prediction only];


The actual alignment was detected with superfamily member COG2319:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 48.75  E-value: 2.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149036511   2 VTADDSGVLCVWrSGPEFTLLTRIAGFGVPCPSVQL--WQGIVAAGYGNGQVRLYDAGTGALHIQISAHARTISALDLAP 79
Cdd:COG2319  304 ASGSDDGTVRLW-DLATGKLLRTLTGHTGAVRSVAFspDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP 382

                         90       100
                 ....*....|....*....|
gi 149036511  80 EVGKLLSAAEDTFVHIWKLN 99
Cdd:COG2319  383 DGRTLASGSADGTVRLWDLA 402
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
2-99 2.27e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 48.75  E-value: 2.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149036511   2 VTADDSGVLCVWrSGPEFTLLTRIAGFGVPCPSVQL--WQGIVAAGYGNGQVRLYDAGTGALHIQISAHARTISALDLAP 79
Cdd:COG2319  304 ASGSDDGTVRLW-DLATGKLLRTLTGHTGAVRSVAFspDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP 382

                         90       100
                 ....*....|....*....|
gi 149036511  80 EVGKLLSAAEDTFVHIWKLN 99
Cdd:COG2319  383 DGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1-97 2.08e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.79  E-value: 2.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149036511   1 MVTADDSGVLCVWRSgPEFTLLTRIAGFGVPCPSVQL--WQGIVAAGYGNGQVRLYDAGTGALHIQISAHARTISALDLA 78
Cdd:cd00200  192 LLSSSSDGTIKLWDL-STGKCLGTLRGHENGVNSVAFspDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWS 270

                         90
                 ....*....|....*....
gi 149036511  79 PEVGKLLSAAEDTFVHIWK 97
Cdd:cd00200  271 PDGKRLASGSADGTIRIWD 289
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 38-75 8.92e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 33.79  E-value: 8.92e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 149036511   38 WQG---IVAAGYGNGQVRLYDAGTGALHIQISAHARTISAL 75
Cdd:pfam12894  46 WRPdgkLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCL 86
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
2-99 2.27e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 48.75  E-value: 2.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149036511   2 VTADDSGVLCVWrSGPEFTLLTRIAGFGVPCPSVQL--WQGIVAAGYGNGQVRLYDAGTGALHIQISAHARTISALDLAP 79
Cdd:COG2319  304 ASGSDDGTVRLW-DLATGKLLRTLTGHTGAVRSVAFspDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP 382

                         90       100
                 ....*....|....*....|
gi 149036511  80 EVGKLLSAAEDTFVHIWKLN 99
Cdd:COG2319  383 DGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1-97 2.08e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.79  E-value: 2.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149036511   1 MVTADDSGVLCVWRSgPEFTLLTRIAGFGVPCPSVQL--WQGIVAAGYGNGQVRLYDAGTGALHIQISAHARTISALDLA 78
Cdd:cd00200  192 LLSSSSDGTIKLWDL-STGKCLGTLRGHENGVNSVAFspDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWS 270

                         90
                 ....*....|....*....
gi 149036511  79 PEVGKLLSAAEDTFVHIWK 97
Cdd:cd00200  271 PDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
41-141 2.31e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.98  E-value: 2.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149036511  41 IVAAGYGNGQVRLYDAGTGALHIQISAHARTISALDLAPEvGKLL-SAAEDTFVHIWKLNRNPESGSIEVEhchgecisD 119
Cdd:COG2319  176 LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD-GKLLaSGSADGTVRLWDLATGKLLRTLTGH--------S 246

                         90       100
                 ....*....|....*....|..
gi 149036511 120 TQVCGARFcDPGGSSFAVTGYD 141
Cdd:COG2319  247 GSVRSVAF-SPDGRLLASGSAD 267
WD40 COG2319
WD40 repeat [General function prediction only];
2-99 7.04e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.44  E-value: 7.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149036511   2 VTADDSGVLCVWRSGPEfTLLTRIAGFGVPCPSVQL-WQG-IVAAGYGNGQVRLYDAGTGALHIQISAHARTISALDLAP 79
Cdd:COG2319  262 ASGSADGTVRLWDLATG-ELLRTLTGHSGGVNSVAFsPDGkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP 340

                         90       100
                 ....*....|....*....|
gi 149036511  80 EVGKLLSAAEDTFVHIWKLN 99
Cdd:COG2319  341 DGKTLASGSDDGTVRLWDLA 360
WD40 COG2319
WD40 repeat [General function prediction only];
40-98 8.28e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.44  E-value: 8.28e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 149036511  40 GIVAAGYGNGQVRLYDAGTGALHIQISAHARTISALDLAPEVGKLLSAAEDTFVHIWKL 98
Cdd:COG2319   91 RLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL 149
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2-131 8.79e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.17  E-value: 8.79e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149036511   2 VTADDSGVLCVWrSGPEFTLLTRIAGF--GVPCPSVQLWQGIVAAGYGNGQVRLYDAGTGALHIQISAHARTISALDLAP 79
Cdd:cd00200  109 SSSSRDKTIKVW-DVETGKCLTTLRGHtdWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSP 187

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 149036511  80 EVGKLLSAAEDTFVHIWKLNrnpesgsieVEHCHGECISDTQ-VCGARFCDPG 131
Cdd:cd00200  188 DGEKLLSSSSDGTIKLWDLS---------TGKCLGTLRGHENgVNSVAFSPDG 231
WD40 COG2319
WD40 repeat [General function prediction only];
41-99 1.12e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.05  E-value: 1.12e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 149036511  41 IVAAGYGNGQVRLYDAGTGALHIQISAHARTISALDLAPEvGKLL-SAAEDTFVHIWKLN 99
Cdd:COG2319  218 LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD-GRLLaSGSADGTVRLWDLA 276
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 39-108 4.94e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 35.77  E-value: 4.94e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149036511  39 QGIVAAGYGNGQVRLYDAGTGALHIQISAHARTISALDLAPEVGKLLSAAEDTFVHIWKLNRNPESGSIE 108
Cdd:cd00200   21 GKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLT 90
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 38-75 8.92e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 33.79  E-value: 8.92e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 149036511   38 WQG---IVAAGYGNGQVRLYDAGTGALHIQISAHARTISAL 75
Cdd:pfam12894  46 WRPdgkLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCL 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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