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Conserved domains on  [gi|149039042|gb|EDL93262|]
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laminin gamma 3 (predicted), isoform CRA_a [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Laminin_N pfam00055
Laminin N-terminal (Domain VI);
44-278 9.98e-107

Laminin N-terminal (Domain VI);


:

Pssm-ID: 459653  Cd Length: 230  Bit Score: 334.94  E-value: 9.98e-107
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149039042    44 CLPEFENAAFGRRAEASHTCGQ-PPEDFCpHVGAPGAGPQCQRCDDADPRRRHDASYLTDFHSPDDSTWWQSPSMAFGVQ 122
Cdd:pfam00055    1 CYPAFGNLAFGREVSATSTCGLnGPERYC-ILSGLEGGKKCFICDSRDPHNSHPPSNLTDSNNGTNETWWQSETGVIQYE 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149039042   123 YptsVNLTLHLGKAYEITYVRLKFHTSRPESFAIYKRTHTGGPWEPYQYYSASCQKTYGHPEGHYLRPGEDErvAFCTSE 202
Cdd:pfam00055   80 N---VNLTLDLGKEFHFTYLILKFKSPRPAAMVLERSTDFGKTWQPYQYFASDCRRTFGRPSGPSRGIKDDE--VICTSE 154

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 149039042   203 FSDISPLNGGNVAFSTLEGRPSAYNFEESPVLQEWVTSTDLLISLDRLNTFGDDIFKDPRVLQSYYYAVSDFSVGG 278
Cdd:pfam00055  155 YSDISPLTGGEVIFSTLEGRPSANIFDYSPELQDWLTATNIRIRLLRLHTLGDELLDDPSVLRKYYYAISDISVGG 230
Laminin_B pfam00052
Laminin B (Domain IV);
549-683 6.69e-30

Laminin B (Domain IV);


:

Pssm-ID: 459652  Cd Length: 136  Bit Score: 115.44  E-value: 6.69e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149039042   549 LSAPEKFLGDQRLSYGQPLILTLQVP--PGGSPPPM--QLRLEGAGLSLALKPSNLPSSQDTrQPGRVQLQFLLQETSEE 624
Cdd:pfam00052    2 WSAPEQFLGNKLTSYGGYLTYTVRYEplPGGGSLNSepDVILEGNGLRLSYSSPDQPPPDPG-QEQTYSVRLHEENWRDS 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 149039042   625 AEPPLPAFHFQRLLSNLTTLSIWTSGQglGHSGHVLLCEVHLTSARPqRGLAPPASWVE 683
Cdd:pfam00052   81 DGAPVSREDFMMVLANLTAILIRATYS--TGSGQVSLSNVSLDSAVP-GGSGPPASWVE 136
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 928-976 4.74e-12

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 61.60  E-value: 4.74e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 149039042   928 CKCHPVGSLENKCHPKTGQCPCRPGVTGQACDRCQLGFFGFSIKGCRDC 976
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 878-925 2.02e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 54.28  E-value: 2.02e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 149039042   878 CSCDPRGSSSqKTCNPATGQCACLPYVTGRDCSRCSPGFYDLQ--PGRGC 925
Cdd:pfam00053    1 CDCNPHGSLS-DTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPsdPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 718-760 6.13e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 52.74  E-value: 6.13e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 149039042  718 PCTCNQHGT----CDPNTGICLCGHHTEGPSCERCMPGFYGNAFSGH 760
Cdd:cd00055     1 PCDCNGHGSlsgqCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGG 47
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 439-486 2.98e-08

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 50.81  E-value: 2.98e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 149039042   439 CTCNVAGSLG-TCDPRSGNCPCKENVEGGLCDRCRPGTFNLQPHNPAGC 486
Cdd:pfam00053    1 CDCNPHGSLSdTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 391-437 8.54e-08

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 49.66  E-value: 8.54e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 149039042  391 PCDCHPAGSLSLQCD-NSGTCPCKLTVTGWKCDRCLPGFHSLSE--GGCR 437
Cdd:cd00055     1 PCDCNGHGSLSGQCDpGTGQCECKPNTTGRRCDRCAPGYYGLPSqgGGCQ 50
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 279-326 1.14e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 46.58  E-value: 1.14e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 149039042  279 RCKCNGHASACGPNEAGQLACHCQHNTTGVDCERCLPFFQDRPWARGT 326
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGG 48
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 821-864 1.32e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 46.19  E-value: 1.32e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 149039042  821 RCQCSRNVDLNavGNCDPHSGRCLrCLHNTTGAHCEHCQEGFYG 864
Cdd:cd00055     1 PCDCNGHGSLS--GQCDPGTGQCE-CKPNTTGRRCDRCAPGYYG 41
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 976-1022 4.84e-06

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 44.65  E-value: 4.84e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 149039042   976 CRCSPLGAASPQCHENS-TCVCRPGFVGYKCDRCQDNFFLVDGDTGCQ 1022
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETgQCLCKPGVTGRHCDRCKPGYYGLPSDPPQG 48
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 766-814 6.12e-04

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 38.87  E-value: 6.12e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 149039042  766 PCPCPGQSACTTIPESRDVVCtHCPPGQRGRRCESCEDGFFGDPLGLSG 814
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQC-ECKPNTTGRRCDRCAPGYYGLPSQGGG 48
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 336-392 2.07e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 37.33  E-value: 2.07e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 149039042   336 CNCSGH---SEECTFdrelyrstgHGGHCQrCRDHTAGPHCEHCEKNYYRwDPKTPCQPC 392
Cdd:pfam00053    1 CDCNPHgslSDTCDP---------ETGQCL-CKPGVTGRHCDRCKPGYYG-LPSDPPQGC 49
 
Name Accession Description Interval E-value
Laminin_N pfam00055
Laminin N-terminal (Domain VI);
44-278 9.98e-107

Laminin N-terminal (Domain VI);


Pssm-ID: 459653  Cd Length: 230  Bit Score: 334.94  E-value: 9.98e-107
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149039042    44 CLPEFENAAFGRRAEASHTCGQ-PPEDFCpHVGAPGAGPQCQRCDDADPRRRHDASYLTDFHSPDDSTWWQSPSMAFGVQ 122
Cdd:pfam00055    1 CYPAFGNLAFGREVSATSTCGLnGPERYC-ILSGLEGGKKCFICDSRDPHNSHPPSNLTDSNNGTNETWWQSETGVIQYE 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149039042   123 YptsVNLTLHLGKAYEITYVRLKFHTSRPESFAIYKRTHTGGPWEPYQYYSASCQKTYGHPEGHYLRPGEDErvAFCTSE 202
Cdd:pfam00055   80 N---VNLTLDLGKEFHFTYLILKFKSPRPAAMVLERSTDFGKTWQPYQYFASDCRRTFGRPSGPSRGIKDDE--VICTSE 154

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 149039042   203 FSDISPLNGGNVAFSTLEGRPSAYNFEESPVLQEWVTSTDLLISLDRLNTFGDDIFKDPRVLQSYYYAVSDFSVGG 278
Cdd:pfam00055  155 YSDISPLTGGEVIFSTLEGRPSANIFDYSPELQDWLTATNIRIRLLRLHTLGDELLDDPSVLRKYYYAISDISVGG 230
LamNT smart00136
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ...
 38-278 8.34e-98

Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins.


Pssm-ID: 214532  Cd Length: 238  Bit Score: 311.22  E-value: 8.34e-98
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149039042     38 AGRAQRCLPEFENAAFGRRAEASHTCGQP-PEDFCPHVGAPGAGPQCQRCDDADPRRRHDASYLTDFHSPDDSTWWQSPS 116
Cdd:smart00136    1 AGRPRSCYPPFVNLAFGREVTATSTCGEPgPERYCKLVGHTEQGKKCDYCDARNPRRSHPAENLTDGNNPNNPTWWQSEP 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149039042    117 MAFGVQYptsVNLTLHLGKAYEITYVRLKFHTSRPeSFAIYKRTHTGGPWEPYQYYSASCQKTYGH-PEGHYLRPGEDEr 195
Cdd:smart00136   81 LSNGPQN---VNLTLDLGKEFHVTYVILKFCSPRP-SLWILERSDFGKTWQPWQYFSSDCRRTFGRpPRGPITKGNEDE- 155

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149039042    196 vAFCTSEFSDISPLNGGNVAFSTLEGRPSAYNFEESPVLQEWVTSTDLLISLDRLNTFGDDIFKD-PRVLQSYYYAVSDF 274
Cdd:smart00136  156 -VICTSEYSDIVPLEGGEIAFSLLEGRPSATDFDNSPVLQEWVTATNIRVRLTRLRTLGDELMDDrPEVTRRYYYAISDI 234


                    ....
gi 149039042    275 SVGG 278
Cdd:smart00136  235 AVGG 238
Laminin_B pfam00052
Laminin B (Domain IV);
549-683 6.69e-30

Laminin B (Domain IV);


Pssm-ID: 459652  Cd Length: 136  Bit Score: 115.44  E-value: 6.69e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149039042   549 LSAPEKFLGDQRLSYGQPLILTLQVP--PGGSPPPM--QLRLEGAGLSLALKPSNLPSSQDTrQPGRVQLQFLLQETSEE 624
Cdd:pfam00052    2 WSAPEQFLGNKLTSYGGYLTYTVRYEplPGGGSLNSepDVILEGNGLRLSYSSPDQPPPDPG-QEQTYSVRLHEENWRDS 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 149039042   625 AEPPLPAFHFQRLLSNLTTLSIWTSGQglGHSGHVLLCEVHLTSARPqRGLAPPASWVE 683
Cdd:pfam00052   81 DGAPVSREDFMMVLANLTAILIRATYS--TGSGQVSLSNVSLDSAVP-GGSGPPASWVE 136
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 928-976 4.74e-12

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 61.60  E-value: 4.74e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 149039042   928 CKCHPVGSLENKCHPKTGQCPCRPGVTGQACDRCQLGFFGFSIKGCRDC 976
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
928-973 1.86e-11

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 60.02  E-value: 1.86e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 149039042    928 CKCHPVGSLENKCHPKTGQCPCRPGVTGQACDRCQLGFFGFSIKGC 973
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
LamB smart00281
Laminin B domain;
550-671 2.42e-11

Laminin B domain;


Pssm-ID: 214597  Cd Length: 127  Bit Score: 62.28  E-value: 2.42e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149039042    550 SAPEKFLGDQRLSYGQPLILTLQ-VPPGGSPPPMQ--LRLEGAGLSLALKPSNLPSSqdtRQPGRVQLQFLLQETSEEAE 626
Cdd:smart00281    8 VAPEQFLGDKVTSYGGKLRYTLSfDGRRGGTHVSApdVILEGNGLRISHPAEGPPLP---DELTTVEVRFREENWQYYGG 84

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*....
gi 149039042    627 PPLPAFHFQRLLSNLTTLSI----WTSGQGLGhsghvlLCEVHLTSARP 671
Cdd:smart00281   85 RPVTREDLMMVLANLTAILIratySQQMAGSR------LSDVSLEVAVP 127
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 927-972 4.65e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 58.90  E-value: 4.65e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 149039042  927 SCKCHPVGSLENKCHPKTGQCPCRPGVTGQACDRCQLGFFGFSIKG 972
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQG 46
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 878-925 2.02e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 54.28  E-value: 2.02e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 149039042   878 CSCDPRGSSSqKTCNPATGQCACLPYVTGRDCSRCSPGFYDLQ--PGRGC 925
Cdd:pfam00053    1 CDCNPHGSLS-DTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPsdPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 877-926 2.21e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 54.28  E-value: 2.21e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 149039042  877 PCSCDPRGSSSQkTCNPATGQCACLPYVTGRDCSRCSPGFYDLQP-GRGCQ 926
Cdd:cd00055     1 PCDCNGHGSLSG-QCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSqGGGCQ 50
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 718-760 6.13e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 52.74  E-value: 6.13e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 149039042  718 PCTCNQHGT----CDPNTGICLCGHHTEGPSCERCMPGFYGNAFSGH 760
Cdd:cd00055     1 PCDCNGHGSlsgqCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGG 47
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 719-764 2.16e-08

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 51.20  E-value: 2.16e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 149039042   719 CTCNQHGT----CDPNTGICLCGHHTEGPSCERCMPGFYGNAfSGHADDC 764
Cdd:pfam00053    1 CDCNPHGSlsdtCDPETGQCLCKPGVTGRHCDRCKPGYYGLP-SDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
878-922 2.32e-08

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 51.16  E-value: 2.32e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 149039042    878 CSCDPRGSSSQkTCNPATGQCACLPYVTGRDCSRCSPGFYDLQPG 922
Cdd:smart00180    1 CDCDPGGSASG-TCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPP 44
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 439-486 2.98e-08

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 50.81  E-value: 2.98e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 149039042   439 CTCNVAGSLG-TCDPRSGNCPCKENVEGGLCDRCRPGTFNLQPHNPAGC 486
Cdd:pfam00053    1 CDCNPHGSLSdTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 438-486 7.59e-08

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 49.66  E-value: 7.59e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 149039042  438 PCTCNVAGSL-GTCDPRSGNCPCKENVEGGLCDRCRPGTFNLqPHNPAGC 486
Cdd:cd00055     1 PCDCNGHGSLsGQCDPGTGQCECKPNTTGRRCDRCAPGYYGL-PSQGGGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 391-437 8.54e-08

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 49.66  E-value: 8.54e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 149039042  391 PCDCHPAGSLSLQCD-NSGTCPCKLTVTGWKCDRCLPGFHSLSE--GGCR 437
Cdd:cd00055     1 PCDCNGHGSLSGQCDpGTGQCECKPNTTGRRCDRCAPGYYGLPSqgGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 392-439 9.20e-08

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 49.66  E-value: 9.20e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 149039042   392 CDCHPAGSLSLQCD-NSGTCPCKLTVTGWKCDRCLPGFHSLSEGGCRPC 439
Cdd:pfam00053    1 CDCNPHGSLSDTCDpETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
719-760 1.16e-07

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 49.23  E-value: 1.16e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 149039042    719 CTCNQHGT----CDPNTGICLCGHHTEGPSCERCMPGFYGNAFSGH 760
Cdd:smart00180    1 CDCDPGGSasgtCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
392-436 1.93e-07

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 48.46  E-value: 1.93e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 149039042    392 CDCHPAGSLSLQCD-NSGTCPCKLTVTGWKCDRCLPGFHSLSEGGC 436
Cdd:smart00180    1 CDCDPGGSASGTCDpDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
439-481 1.10e-06

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 46.54  E-value: 1.10e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 149039042    439 CTCNVAGSL-GTCDPRSGNCPCKENVEGGLCDRCRPGTFNLQPH 481
Cdd:smart00180    1 CDCDPGGSAsGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPP 44
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 279-326 1.14e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 46.58  E-value: 1.14e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 149039042  279 RCKCNGHASACGPNEAGQLACHCQHNTTGVDCERCLPFFQDRPWARGT 326
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGG 48
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 821-864 1.32e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 46.19  E-value: 1.32e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 149039042  821 RCQCSRNVDLNavGNCDPHSGRCLrCLHNTTGAHCEHCQEGFYG 864
Cdd:cd00055     1 PCDCNGHGSLS--GQCDPGTGQCE-CKPNTTGRRCDRCAPGYYG 41
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 822-864 3.14e-06

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 45.04  E-value: 3.14e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 149039042   822 CQCSRNVDLNavGNCDPHSGRCLrCLHNTTGAHCEHCQEGFYG 864
Cdd:pfam00053    1 CDCNPHGSLS--DTCDPETGQCL-CKPGVTGRHCDRCKPGYYG 40
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 976-1022 4.84e-06

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 44.65  E-value: 4.84e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 149039042   976 CRCSPLGAASPQCHENS-TCVCRPGFVGYKCDRCQDNFFLVDGDTGCQ 1022
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETgQCLCKPGVTGRHCDRCKPGYYGLPSDPPQG 48
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
822-865 1.08e-05

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 43.45  E-value: 1.08e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 149039042    822 CQCsrNVDLNAVGNCDPHSGRCLrCLHNTTGAHCEHCQEGFYGS 865
Cdd:smart00180    1 CDC--DPGGSASGTCDPDTGQCE-CKPNVTGRRCDRCAPGYYGD 41
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 976-1022 1.34e-05

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 43.50  E-value: 1.34e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 149039042  976 CRCSPLGAASPQCHENS-TCVCRPGFVGYKCDRCQDNFF-LVDGDTGCQ 1022
Cdd:cd00055     2 CDCNGHGSLSGQCDPGTgQCECKPNTTGRRCDRCAPGYYgLPSQGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 280-321 2.92e-05

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 42.34  E-value: 2.92e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 149039042   280 CKCNGHASACGPNEAGQLACHCQHNTTGVDCERCLPFFQDRP 321
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLP 42
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
976-1019 3.50e-05

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 42.30  E-value: 3.50e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 149039042    976 CRCSPLGAASPQCHENS-TCVCRPGFVGYKCDRCQDNFFLVDGDT 1019
Cdd:smart00180    1 CDCDPGGSASGTCDPDTgQCECKPNVTGRRCDRCAPGYYGDGPPG 45
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 766-814 6.12e-04

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 38.87  E-value: 6.12e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 149039042  766 PCPCPGQSACTTIPESRDVVCtHCPPGQRGRRCESCEDGFFGDPLGLSG 814
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQC-ECKPNTTGRRCDRCAPGYYGLPSQGGG 48
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 336-392 2.07e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 37.33  E-value: 2.07e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 149039042   336 CNCSGH---SEECTFdrelyrstgHGGHCQrCRDHTAGPHCEHCEKNYYRwDPKTPCQPC 392
Cdd:pfam00053    1 CDCNPHgslSDTCDP---------ETGQCL-CKPGVTGRHCDRCKPGYYG-LPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
280-317 3.86e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 36.52  E-value: 3.86e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 149039042    280 CKCNGHASACGPNEAGQLACHCQHNTTGVDCERCLPFF 317
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGY 38
 
Name Accession Description Interval E-value
Laminin_N pfam00055
Laminin N-terminal (Domain VI);
44-278 9.98e-107

Laminin N-terminal (Domain VI);


Pssm-ID: 459653  Cd Length: 230  Bit Score: 334.94  E-value: 9.98e-107
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149039042    44 CLPEFENAAFGRRAEASHTCGQ-PPEDFCpHVGAPGAGPQCQRCDDADPRRRHDASYLTDFHSPDDSTWWQSPSMAFGVQ 122
Cdd:pfam00055    1 CYPAFGNLAFGREVSATSTCGLnGPERYC-ILSGLEGGKKCFICDSRDPHNSHPPSNLTDSNNGTNETWWQSETGVIQYE 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149039042   123 YptsVNLTLHLGKAYEITYVRLKFHTSRPESFAIYKRTHTGGPWEPYQYYSASCQKTYGHPEGHYLRPGEDErvAFCTSE 202
Cdd:pfam00055   80 N---VNLTLDLGKEFHFTYLILKFKSPRPAAMVLERSTDFGKTWQPYQYFASDCRRTFGRPSGPSRGIKDDE--VICTSE 154

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 149039042   203 FSDISPLNGGNVAFSTLEGRPSAYNFEESPVLQEWVTSTDLLISLDRLNTFGDDIFKDPRVLQSYYYAVSDFSVGG 278
Cdd:pfam00055  155 YSDISPLTGGEVIFSTLEGRPSANIFDYSPELQDWLTATNIRIRLLRLHTLGDELLDDPSVLRKYYYAISDISVGG 230
LamNT smart00136
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ...
 38-278 8.34e-98

Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins.


Pssm-ID: 214532  Cd Length: 238  Bit Score: 311.22  E-value: 8.34e-98
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149039042     38 AGRAQRCLPEFENAAFGRRAEASHTCGQP-PEDFCPHVGAPGAGPQCQRCDDADPRRRHDASYLTDFHSPDDSTWWQSPS 116
Cdd:smart00136    1 AGRPRSCYPPFVNLAFGREVTATSTCGEPgPERYCKLVGHTEQGKKCDYCDARNPRRSHPAENLTDGNNPNNPTWWQSEP 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149039042    117 MAFGVQYptsVNLTLHLGKAYEITYVRLKFHTSRPeSFAIYKRTHTGGPWEPYQYYSASCQKTYGH-PEGHYLRPGEDEr 195
Cdd:smart00136   81 LSNGPQN---VNLTLDLGKEFHVTYVILKFCSPRP-SLWILERSDFGKTWQPWQYFSSDCRRTFGRpPRGPITKGNEDE- 155

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149039042    196 vAFCTSEFSDISPLNGGNVAFSTLEGRPSAYNFEESPVLQEWVTSTDLLISLDRLNTFGDDIFKD-PRVLQSYYYAVSDF 274
Cdd:smart00136  156 -VICTSEYSDIVPLEGGEIAFSLLEGRPSATDFDNSPVLQEWVTATNIRVRLTRLRTLGDELMDDrPEVTRRYYYAISDI 234


                    ....
gi 149039042    275 SVGG 278
Cdd:smart00136  235 AVGG 238
Laminin_B pfam00052
Laminin B (Domain IV);
549-683 6.69e-30

Laminin B (Domain IV);


Pssm-ID: 459652  Cd Length: 136  Bit Score: 115.44  E-value: 6.69e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149039042   549 LSAPEKFLGDQRLSYGQPLILTLQVP--PGGSPPPM--QLRLEGAGLSLALKPSNLPSSQDTrQPGRVQLQFLLQETSEE 624
Cdd:pfam00052    2 WSAPEQFLGNKLTSYGGYLTYTVRYEplPGGGSLNSepDVILEGNGLRLSYSSPDQPPPDPG-QEQTYSVRLHEENWRDS 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 149039042   625 AEPPLPAFHFQRLLSNLTTLSIWTSGQglGHSGHVLLCEVHLTSARPqRGLAPPASWVE 683
Cdd:pfam00052   81 DGAPVSREDFMMVLANLTAILIRATYS--TGSGQVSLSNVSLDSAVP-GGSGPPASWVE 136
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 928-976 4.74e-12

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 61.60  E-value: 4.74e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 149039042   928 CKCHPVGSLENKCHPKTGQCPCRPGVTGQACDRCQLGFFGFSIKGCRDC 976
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
928-973 1.86e-11

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 60.02  E-value: 1.86e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 149039042    928 CKCHPVGSLENKCHPKTGQCPCRPGVTGQACDRCQLGFFGFSIKGC 973
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
LamB smart00281
Laminin B domain;
550-671 2.42e-11

Laminin B domain;


Pssm-ID: 214597  Cd Length: 127  Bit Score: 62.28  E-value: 2.42e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149039042    550 SAPEKFLGDQRLSYGQPLILTLQ-VPPGGSPPPMQ--LRLEGAGLSLALKPSNLPSSqdtRQPGRVQLQFLLQETSEEAE 626
Cdd:smart00281    8 VAPEQFLGDKVTSYGGKLRYTLSfDGRRGGTHVSApdVILEGNGLRISHPAEGPPLP---DELTTVEVRFREENWQYYGG 84

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*....
gi 149039042    627 PPLPAFHFQRLLSNLTTLSI----WTSGQGLGhsghvlLCEVHLTSARP 671
Cdd:smart00281   85 RPVTREDLMMVLANLTAILIratySQQMAGSR------LSDVSLEVAVP 127
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 927-972 4.65e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 58.90  E-value: 4.65e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 149039042  927 SCKCHPVGSLENKCHPKTGQCPCRPGVTGQACDRCQLGFFGFSIKG 972
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQG 46
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 878-925 2.02e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 54.28  E-value: 2.02e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 149039042   878 CSCDPRGSSSqKTCNPATGQCACLPYVTGRDCSRCSPGFYDLQ--PGRGC 925
Cdd:pfam00053    1 CDCNPHGSLS-DTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPsdPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 877-926 2.21e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 54.28  E-value: 2.21e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 149039042  877 PCSCDPRGSSSQkTCNPATGQCACLPYVTGRDCSRCSPGFYDLQP-GRGCQ 926
Cdd:cd00055     1 PCDCNGHGSLSG-QCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSqGGGCQ 50
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 718-760 6.13e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 52.74  E-value: 6.13e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 149039042  718 PCTCNQHGT----CDPNTGICLCGHHTEGPSCERCMPGFYGNAFSGH 760
Cdd:cd00055     1 PCDCNGHGSlsgqCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGG 47
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 719-764 2.16e-08

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 51.20  E-value: 2.16e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 149039042   719 CTCNQHGT----CDPNTGICLCGHHTEGPSCERCMPGFYGNAfSGHADDC 764
Cdd:pfam00053    1 CDCNPHGSlsdtCDPETGQCLCKPGVTGRHCDRCKPGYYGLP-SDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
878-922 2.32e-08

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 51.16  E-value: 2.32e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 149039042    878 CSCDPRGSSSQkTCNPATGQCACLPYVTGRDCSRCSPGFYDLQPG 922
Cdd:smart00180    1 CDCDPGGSASG-TCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPP 44
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 439-486 2.98e-08

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 50.81  E-value: 2.98e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 149039042   439 CTCNVAGSLG-TCDPRSGNCPCKENVEGGLCDRCRPGTFNLQPHNPAGC 486
Cdd:pfam00053    1 CDCNPHGSLSdTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 438-486 7.59e-08

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 49.66  E-value: 7.59e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 149039042  438 PCTCNVAGSL-GTCDPRSGNCPCKENVEGGLCDRCRPGTFNLqPHNPAGC 486
Cdd:cd00055     1 PCDCNGHGSLsGQCDPGTGQCECKPNTTGRRCDRCAPGYYGL-PSQGGGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 391-437 8.54e-08

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 49.66  E-value: 8.54e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 149039042  391 PCDCHPAGSLSLQCD-NSGTCPCKLTVTGWKCDRCLPGFHSLSE--GGCR 437
Cdd:cd00055     1 PCDCNGHGSLSGQCDpGTGQCECKPNTTGRRCDRCAPGYYGLPSqgGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 392-439 9.20e-08

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 49.66  E-value: 9.20e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 149039042   392 CDCHPAGSLSLQCD-NSGTCPCKLTVTGWKCDRCLPGFHSLSEGGCRPC 439
Cdd:pfam00053    1 CDCNPHGSLSDTCDpETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
719-760 1.16e-07

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 49.23  E-value: 1.16e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 149039042    719 CTCNQHGT----CDPNTGICLCGHHTEGPSCERCMPGFYGNAFSGH 760
Cdd:smart00180    1 CDCDPGGSasgtCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
392-436 1.93e-07

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 48.46  E-value: 1.93e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 149039042    392 CDCHPAGSLSLQCD-NSGTCPCKLTVTGWKCDRCLPGFHSLSEGGC 436
Cdd:smart00180    1 CDCDPGGSASGTCDpDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
439-481 1.10e-06

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 46.54  E-value: 1.10e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 149039042    439 CTCNVAGSL-GTCDPRSGNCPCKENVEGGLCDRCRPGTFNLQPH 481
Cdd:smart00180    1 CDCDPGGSAsGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPP 44
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 279-326 1.14e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 46.58  E-value: 1.14e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 149039042  279 RCKCNGHASACGPNEAGQLACHCQHNTTGVDCERCLPFFQDRPWARGT 326
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGG 48
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 821-864 1.32e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 46.19  E-value: 1.32e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 149039042  821 RCQCSRNVDLNavGNCDPHSGRCLrCLHNTTGAHCEHCQEGFYG 864
Cdd:cd00055     1 PCDCNGHGSLS--GQCDPGTGQCE-CKPNTTGRRCDRCAPGYYG 41
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 822-864 3.14e-06

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 45.04  E-value: 3.14e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 149039042   822 CQCSRNVDLNavGNCDPHSGRCLrCLHNTTGAHCEHCQEGFYG 864
Cdd:pfam00053    1 CDCNPHGSLS--DTCDPETGQCL-CKPGVTGRHCDRCKPGYYG 40
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 976-1022 4.84e-06

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 44.65  E-value: 4.84e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 149039042   976 CRCSPLGAASPQCHENS-TCVCRPGFVGYKCDRCQDNFFLVDGDTGCQ 1022
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETgQCLCKPGVTGRHCDRCKPGYYGLPSDPPQG 48
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
822-865 1.08e-05

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 43.45  E-value: 1.08e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 149039042    822 CQCsrNVDLNAVGNCDPHSGRCLrCLHNTTGAHCEHCQEGFYGS 865
Cdd:smart00180    1 CDC--DPGGSASGTCDPDTGQCE-CKPNVTGRRCDRCAPGYYGD 41
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 976-1022 1.34e-05

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 43.50  E-value: 1.34e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 149039042  976 CRCSPLGAASPQCHENS-TCVCRPGFVGYKCDRCQDNFF-LVDGDTGCQ 1022
Cdd:cd00055     2 CDCNGHGSLSGQCDPGTgQCECKPNTTGRRCDRCAPGYYgLPSQGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 280-321 2.92e-05

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 42.34  E-value: 2.92e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 149039042   280 CKCNGHASACGPNEAGQLACHCQHNTTGVDCERCLPFFQDRP 321
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLP 42
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
976-1019 3.50e-05

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 42.30  E-value: 3.50e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 149039042    976 CRCSPLGAASPQCHENS-TCVCRPGFVGYKCDRCQDNFFLVDGDT 1019
Cdd:smart00180    1 CDCDPGGSASGTCDPDTgQCECKPNVTGRRCDRCAPGYYGDGPPG 45
TNFRSF6B cd10575
Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B), also known as decoy receptor ...
 721-789 2.72e-04

Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B), also known as decoy receptor 3 (DcR3); The subfamily TNFRSF6B is also known as decoy receptor 3 (DcR3), M68, or TR6. This protein is a soluble receptor without death domain and cytoplasmic domain, and secreted by cells. It acts as a decoy receptor that competes with death receptors for ligand binding. It is a pleiotropic immunomodulator and biomarker for inflammatory diseases, autoimmune diseases, and cancer. Over-expression of this gene has been noted in several cancers, including pancreatic carcinoma, and gastrointestinal tract tumors. It can neutralize the biological effects of three tumor necrosis factor superfamily (TNFSF) members: TNFSF6 (Fas ligand/FasL/CD95L) and TNFSF14 (LIGHT) which are both involved in apoptosis and inflammation, and TNFSF15 (TNF-like molecule 1A/TL1A), which is a T cell co-stimulator and involved in gut inflammation. DcR3 is a novel inflammatory marker; higher DcR3 levels strongly correlate with inflammation and independently predict cardiovascular and all-cause mortality in chronic kidney disease (CKD) patients on hemodialysis. Increased synovial inflammatory cells infiltration in rheumatoid arthritis and ankylosing spondylitis is also associated with the elevated DcR3 expression. In cartilaginous fish, mRNA expression of DcR3 in the thymus and leydig, which are the representative lymphoid tissues of elasmobranchs, suggests that DcR3 may act as a modulator in the immune system. Interestingly, in banded dogfish (Triakis scyllia), DcR3 mRNA is strongly expressed in the gill, compared with human expression in the normal lung; both are respiratory organs, suggesting potential relevance of DcR3 to respiratory function.


Pssm-ID: 276901 [Multi-domain]  Cd Length: 163  Bit Score: 42.78  E-value: 2.72e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 149039042  721 CNQHGTCDPNTGICLCGHHTEGPSCERCMPGFYgNAFSGHADDCQP-CPCPGQSACTTIP--ESRDVVCTHC 789
Cdd:cd10575    93 CLRHSSCPPGEGVIKLGTPYSDTQCEPCPPGFF-SASSSSTEPCQPhTNCTQGGLETNVPgnDYHDTLCTSC 163
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 766-814 6.12e-04

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 38.87  E-value: 6.12e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 149039042  766 PCPCPGQSACTTIPESRDVVCtHCPPGQRGRRCESCEDGFFGDPLGLSG 814
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQC-ECKPNTTGRRCDRCAPGYYGLPSQGGG 48
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 336-392 2.07e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 37.33  E-value: 2.07e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 149039042   336 CNCSGH---SEECTFdrelyrstgHGGHCQrCRDHTAGPHCEHCEKNYYRwDPKTPCQPC 392
Cdd:pfam00053    1 CDCNPHgslSDTCDP---------ETGQCL-CKPGVTGRHCDRCKPGYYG-LPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
280-317 3.86e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 36.52  E-value: 3.86e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 149039042    280 CKCNGHASACGPNEAGQLACHCQHNTTGVDCERCLPFF 317
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGY 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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