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Conserved domains on  [gi|149041224|gb|EDL95157|]
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retinoblastoma binding protein 9, isoform CRA_b [Rattus norvegicus]

Protein Classification

RBBP9/YdeN family alpha/beta hydrolase( domain architecture ID 1903367)

RBBP9/YdeN family alpha/beta hydrolase has serine hydrolase activity, similar to human serine hydrolase RBBP9 (retinoblastoma-binding protein 9)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YdeN super family cl42716
Predicted esterase of the alpha/beta hydrolase fold [General function prediction only];
8-99 1.10e-13

Predicted esterase of the alpha/beta hydrolase fold [General function prediction only];


The actual alignment was detected with superfamily member COG3545:

Pssm-ID: 442766 [Multi-domain]  Cd Length: 170  Bit Score: 63.33  E-value: 1.10e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041224   8 VIVPGNGGGDvATHgWYGWVRkglEQIPGFQCLAknMPDPITARESIWLPFMETELH-CDEKTIIIGHSSGAIAAMRYAE 86
Cdd:COG3545    1 LIVPGLGGSG-PDH-WQSWWE---RELPTVRRVE--QPDWDRPDLDDWLAALDAAVAaADGPVVLVAHSLGCLAVAHWAA 73

                         90
                 ....*....|....*
gi 149041224  87 THQ--VYALILVSAY 99
Cdd:COG3545   74 RLPrkVAGALLVAPP 88
 
Name Accession Description Interval E-value
YdeN COG3545
Predicted esterase of the alpha/beta hydrolase fold [General function prediction only];
8-99 1.10e-13

Predicted esterase of the alpha/beta hydrolase fold [General function prediction only];


Pssm-ID: 442766 [Multi-domain]  Cd Length: 170  Bit Score: 63.33  E-value: 1.10e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041224   8 VIVPGNGGGDvATHgWYGWVRkglEQIPGFQCLAknMPDPITARESIWLPFMETELH-CDEKTIIIGHSSGAIAAMRYAE 86
Cdd:COG3545    1 LIVPGLGGSG-PDH-WQSWWE---RELPTVRRVE--QPDWDRPDLDDWLAALDAAVAaADGPVVLVAHSLGCLAVAHWAA 73

                         90
                 ....*....|....*
gi 149041224  87 THQ--VYALILVSAY 99
Cdd:COG3545   74 RLPrkVAGALLVAPP 88
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 8-98 2.19e-04

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 39.02  E-value: 2.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041224    8 VIVPGNGGGdvaTHGWYGWVRkGLEQiPGFQCLAKNMPDPITARESIWLPFMETELHCD-----------EKTIIIGHSS 76
Cdd:pfam00561   4 LLLHGLPGS---SDLWRKLAP-ALAR-DGFRVIALDLRGFGKSSRPKAQDDYRTDDLAEdleyilealglEKVNLVGHSM 78

                          90       100
                  ....*....|....*....|....
gi 149041224   77 GAIAAMRYAETHQ--VYALILVSA 98
Cdd:pfam00561  79 GGLIALAYAAKYPdrVKALVLLGA 102
 
Name Accession Description Interval E-value
YdeN COG3545
Predicted esterase of the alpha/beta hydrolase fold [General function prediction only];
8-99 1.10e-13

Predicted esterase of the alpha/beta hydrolase fold [General function prediction only];


Pssm-ID: 442766 [Multi-domain]  Cd Length: 170  Bit Score: 63.33  E-value: 1.10e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041224   8 VIVPGNGGGDvATHgWYGWVRkglEQIPGFQCLAknMPDPITARESIWLPFMETELH-CDEKTIIIGHSSGAIAAMRYAE 86
Cdd:COG3545    1 LIVPGLGGSG-PDH-WQSWWE---RELPTVRRVE--QPDWDRPDLDDWLAALDAAVAaADGPVVLVAHSLGCLAVAHWAA 73

                         90
                 ....*....|....*
gi 149041224  87 THQ--VYALILVSAY 99
Cdd:COG3545   74 RLPrkVAGALLVAPP 88
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 8-98 2.19e-04

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 39.02  E-value: 2.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041224    8 VIVPGNGGGdvaTHGWYGWVRkGLEQiPGFQCLAKNMPDPITARESIWLPFMETELHCD-----------EKTIIIGHSS 76
Cdd:pfam00561   4 LLLHGLPGS---SDLWRKLAP-ALAR-DGFRVIALDLRGFGKSSRPKAQDDYRTDDLAEdleyilealglEKVNLVGHSM 78

                          90       100
                  ....*....|....*....|....
gi 149041224   77 GAIAAMRYAETHQ--VYALILVSA 98
Cdd:pfam00561  79 GGLIALAYAAKYPdrVKALVLLGA 102
Ser_hydrolase pfam06821
Serine hydrolase; Members of this family have serine hydrolase activity. They contain a ...
 8-97 2.37e-04

Serine hydrolase; Members of this family have serine hydrolase activity. They contain a conserved serine hydrolase motif, GXSXG/A, where the serine is a putative nucleophile. This family has an alpha-beta hydrolase fold. Eukaryotic members of this family have a conserved LXCXE motif, which binds to retinoblastomas. This motif is absent from prokaryotic members of this family.


Pssm-ID: 399658 [Multi-domain]  Cd Length: 171  Bit Score: 38.47  E-value: 2.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041224    8 VIVPGNGGGDvATHgWYGWVRKGLEQipgfqCLAKNMPDPITARESIWLPFMETELH-CDEKTIIIGHSSGAIAAMRYAE 86
Cdd:pfam06821   2 LIVPGWGGSG-PGH-WQSHWERRLPA-----ARRVEQDDWLQPVLDDWVAALSRAVAaLPGPVILVAHSLGCLAVAHWAA 74

                          90
                  ....*....|....
gi 149041224   87 ---THQVYALILVS 97
Cdd:pfam06821  75 lqlRAKVAGALLVA 88
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 67-98 8.25e-04

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 37.29  E-value: 8.25e-04
                         10        20        30
                 ....*....|....*....|....*....|....
gi 149041224  67 EKTIIIGHSSGAIAAMRYAETH--QVYALILVSA 98
Cdd:COG0596   89 ERVVLVGHSMGGMVALELAARHpeRVAGLVLVDE 122
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
66-102 8.66e-04

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 37.29  E-value: 8.66e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 149041224  66 DEKTIIIGHSSGAIAAMRYAETHQ--VYALILVS-AYTSD 102
Cdd:COG2267   98 GLPVVLLGHSMGGLIALLYAARYPdrVAGLVLLApAYRAD 137
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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