FXYD domain-containing ion transport regulator 2; FXYD domain-containing ion transport regulator 2 (FXYD2), also known as sodium/potassium-transporting ATPase subunit gamma, or Na(+)/K(+) ATPase subunit gamma, or sodium pump gamma chain, is the regulatory subunit of the sodium/potassium-transporting ATPase (Na,K-ATPase). Na+,K+-ATPase is a heteromeric complex consisting of a large alpha-subunit, which is responsible for ATP hydrolysis, ion transport, and CTS binding, and a beta-subunit, acting as a chaperone. Although the Na,K-ATPase does not depend on the gamma subunit to be functional, it is thought that the gamma subunit modulates the enzyme's activity by inducing ion channel activity. Mutations in this gene have been associated with renal hypomagnesaemia.

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gi 149041525  8 GSAKGTENPFEYDYETVRKGGLIFAGLAFVVGLLILLKETW 48
Cdd:cd20318   1 GSPEGSEDPFTYDYETVRNGGLIFAAVAFVVGLLIILSKRF 41

FXYD domain-containing ion transport regulator 2; FXYD domain-containing ion transport regulator 2 (FXYD2), also known as sodium/potassium-transporting ATPase subunit gamma, or Na(+)/K(+) ATPase subunit gamma, or sodium pump gamma chain, is the regulatory subunit of the sodium/potassium-transporting ATPase (Na,K-ATPase). Na+,K+-ATPase is a heteromeric complex consisting of a large alpha-subunit, which is responsible for ATP hydrolysis, ion transport, and CTS binding, and a beta-subunit, acting as a chaperone. Although the Na,K-ATPase does not depend on the gamma subunit to be functional, it is thought that the gamma subunit modulates the enzyme's activity by inducing ion channel activity. Mutations in this gene have been associated with renal hypomagnesaemia.

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                ....*....|....*....|....*....|....*....|.
gi 149041525  8 GSAKGTENPFEYDYETVRKGGLIFAGLAFVVGLLILLKETW 48
Cdd:cd20318   1 GSPEGSEDPFTYDYETVRNGGLIFAAVAFVVGLLIILSKRF 41

FXYD domain-containing ion transport regulator 2; FXYD domain-containing ion transport regulator 2 (FXYD2), also known as sodium/potassium-transporting ATPase subunit gamma, or Na(+)/K(+) ATPase subunit gamma, or sodium pump gamma chain, is the regulatory subunit of the sodium/potassium-transporting ATPase (Na,K-ATPase). Na+,K+-ATPase is a heteromeric complex consisting of a large alpha-subunit, which is responsible for ATP hydrolysis, ion transport, and CTS binding, and a beta-subunit, acting as a chaperone. Although the Na,K-ATPase does not depend on the gamma subunit to be functional, it is thought that the gamma subunit modulates the enzyme's activity by inducing ion channel activity. Mutations in this gene have been associated with renal hypomagnesaemia.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 149041525  8 GSAKGTENPFEYDYETVRKGGLIFAGLAFVVGLLILLKETW 48
Cdd:cd20318   1 GSPEGSEDPFTYDYETVRNGGLIFAAVAFVVGLLIILSKRF 41

FXYD domain-containing ion transport regulator 1; FXYD domain-containing ion transport regulator 1 (FXYD1), also known as phospholemman (PLM), or sodium/potassium-transporting ATPase subunit FXYD1, associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na+ out of the cell and K+ into the cell. It is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity. Transcript variants with different 5' UTR sequences have been described in the literature.

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gi 149041525 16 PFEYDYETVRKGGLIFAGLAFVVGLLILLKET-WIPSPTLWCCWrrEVNPEELALPGSP 73
Cdd:cd20317   6 PFTYDYQSLRIGGLIIAGILFILGILIILSRRcRCKFNQQQRTG--EPDEEEGTFRSSI 62

FXYD domain of FXYD domain-containing ion transport regulator 5; FXYD domain-containing ion transport regulator 5 (FXYD5) is also called dysadherin in humans or related to ion channel (RIC) in mice. Two transcript variants have been found for this gene, and they are both predicted to encode the same protein. Dysadherin is the gamma subunit the human Na,K-ATPase and is the only member that has a large extracellular sequence of 140 amino acids. Dysadherin has been observed to be over-expressed on the surface of cells that have down regulated levels of surface E-cadherin. CCL2 (bone homing cytokine) is a protein that is highly affected by silencing dysadherin expression. Dysadherin interferes with cell adhesion via beta1 subunit interactions and is a target for an extracellular antibody drug conjugate where the antibody to dysadherin is attached to a cardiac glycoside. FXYD5 expression in mouse is mainly in the kidney, intestine, spleen, and lung. Confocal immunofluorescence microscopy of mouse kidney detected FXYD5 on basolateral membranes of connecting tubules, collecting tubules, intercalated cells of collecting duct, and on apical membranes in long thin limb of Henle loop.

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gi 149041525 14 ENPFEYDYETVRKGGLIFAGLAFVVGLLIL 43
Cdd:cd20323   5 DEPFTYDYETLRKAGLIIAAVLFITGILVL 34

FXYD domain-containing ion transport regulator 6; FXYD domain-containing ion transport regulator 6 (FXYD6 encodes the protein phosphohippolin and is located at the 11q23.3. It can be found in all human tissues except blood. FXYD6 in humans is primarily in the brain, with highest levels of expression found in the prefrontal cortex, amygdala, hypothalamus, and occipital lobe. FXYD6 is up-regulated in hepatocellular carcinoma (HCC) and it enhances the migration and proliferation of HCC cells. Therapy targeting FXYD6 could potentially benefit the clinical treatment toward HCC patients. FXYD6 is also associated with mental diseases. Mutations in the FXYD6 gene, or in sequences close to this gene, can predispose to schizophrenia which is known to be strongly heritable. FXYD6 was also found to be significantly downregulated in a Tg2576 mouse model of Alzheimer's disease (AD) brain and hippocampus. FXYD6 is a novel regulator of Na,K-ATPase expressed in the inner ear.

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gi 149041525 14 ENPFEYDYETVRKGGLIFAGLAFVVG-LLIL 43
Cdd:cd20324  26 DSPFHYDYESLRIGGLVFAVVLFLLGiLLIL 56

FXYD domain-containing ion transport regulator 11; FXYD domain-containing ion transport regulator 11 (FXYD11) is a putative regulatory subunit of the Na(+)/K(+)-ATPase (NKA) pump. FXYD11 is expressed predominantly in the gills of euryhaline teleosts, such as the spotted scat, Scatophagus argus. It regulates NKA activity through protein-protein interactions. The regulation of NKA and FXYD11 is of critical importance for osmotic homeostasis. The expression and activity of NKA, as well as FXYD11 mRNA expression in gills have been shown to respond to different environmental salinity by dual-labeling immunohistochemistry and quantitative PCR (RT-qPCR) methods, indicating that there is an interaction between NKA and FXYD.

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gi 149041525 15 NPFEYDYETVRKGGLIFAGLAFVVGLLILL 44
Cdd:cd20329  23 NPFVYNYERLRIGGLVFACLLVAGGISVLL 52

FXYD domain-containing ion transport regulator 4; FXYD domain-containing ion transport regulator 4 (FXYD4), also known as CHIF (channel-inducing factor or corticosteroid hormone-induced factor), evokes K+ conductance in oocytes and is localized in the distal parts of the nephron and in the colon. CHIF, a putative K channel regulator, is regulated by aldosterone in the colon and by K+ intake in the kidney.

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gi 149041525 14 ENPFEYDYETVRKGGLIFAGLAFVVGLLILL 44
Cdd:cd20322   7 DSPFYYDWESLQLGGMICAGLLCIAGIAFAL 37