Tetratricopeptide repeat protein 7 N-terminal; This is the N-terminal domain of TTC7, a ...
11-404
2.47e-146
Tetratricopeptide repeat protein 7 N-terminal; This is the N-terminal domain of TTC7, a protein that forms the regulatory subunit of the PI4KIIIalpha complex (also known as PI4KA). This complex is composed of PI4KIIIalpha, TTC7 and FAM126A and catalyzes the first step in plasma membrane phosphoinositide synthesis. This TTC7 N-terminal domain contains basic residues suitable for interaction with the acidic inner leaflet of the plasma membrane and is required for localising the active site near its substrate. TTC7 acts as a bridge between PI4KA and EFR3B-FAM126A, via direct interactions. ERF3B is not part of the complex but contributes to its recruitment to the membrane.
The actual alignment was detected with superfamily member pfam19440:
Pssm-ID: 466084 Cd Length: 386 Bit Score: 429.58 E-value: 2.47e-146
Tetratricopeptide repeat protein 7 N-terminal; This is the N-terminal domain of TTC7, a ...
11-404
2.47e-146
Tetratricopeptide repeat protein 7 N-terminal; This is the N-terminal domain of TTC7, a protein that forms the regulatory subunit of the PI4KIIIalpha complex (also known as PI4KA). This complex is composed of PI4KIIIalpha, TTC7 and FAM126A and catalyzes the first step in plasma membrane phosphoinositide synthesis. This TTC7 N-terminal domain contains basic residues suitable for interaction with the acidic inner leaflet of the plasma membrane and is required for localising the active site near its substrate. TTC7 acts as a bridge between PI4KA and EFR3B-FAM126A, via direct interactions. ERF3B is not part of the complex but contributes to its recruitment to the membrane.
Pssm-ID: 466084 Cd Length: 386 Bit Score: 429.58 E-value: 2.47e-146
cargo-transport protein YPP1; This family includes YGR198w (named YPP1, also called ...
485-554
4.28e-03
cargo-transport protein YPP1; This family includes YGR198w (named YPP1, also called alpha-synuclein protective protein 1), which is essential in Saccharomyces cerevisiae. It has also been shown to perform fundamental functions in human and mouse. YPP1 is a cargo-transport protein involved in endocytosis. It interacts with genes involved in protein sorting and secretion, and plays a role in the assembly and recruitment of multiple copies of the kinase into phosphoinositide kinase (PIK) patches at the plasma membrane. It has been found to suppress the toxicity of alpha-synuclein (alpha-syn) mutant (A30P) that is associated with early onset of Parkinson's disease (PD) in humans, but not wild-type or the A53T mutant (also associated with early onset PD).
Pssm-ID: 438014 [Multi-domain] Cd Length: 740 Bit Score: 40.34 E-value: 4.28e-03
Tetratricopeptide repeat protein 7 N-terminal; This is the N-terminal domain of TTC7, a ...
11-404
2.47e-146
Tetratricopeptide repeat protein 7 N-terminal; This is the N-terminal domain of TTC7, a protein that forms the regulatory subunit of the PI4KIIIalpha complex (also known as PI4KA). This complex is composed of PI4KIIIalpha, TTC7 and FAM126A and catalyzes the first step in plasma membrane phosphoinositide synthesis. This TTC7 N-terminal domain contains basic residues suitable for interaction with the acidic inner leaflet of the plasma membrane and is required for localising the active site near its substrate. TTC7 acts as a bridge between PI4KA and EFR3B-FAM126A, via direct interactions. ERF3B is not part of the complex but contributes to its recruitment to the membrane.
Pssm-ID: 466084 Cd Length: 386 Bit Score: 429.58 E-value: 2.47e-146
cargo-transport protein YPP1; This family includes YGR198w (named YPP1, also called ...
485-554
4.28e-03
cargo-transport protein YPP1; This family includes YGR198w (named YPP1, also called alpha-synuclein protective protein 1), which is essential in Saccharomyces cerevisiae. It has also been shown to perform fundamental functions in human and mouse. YPP1 is a cargo-transport protein involved in endocytosis. It interacts with genes involved in protein sorting and secretion, and plays a role in the assembly and recruitment of multiple copies of the kinase into phosphoinositide kinase (PIK) patches at the plasma membrane. It has been found to suppress the toxicity of alpha-synuclein (alpha-syn) mutant (A30P) that is associated with early onset of Parkinson's disease (PD) in humans, but not wild-type or the A53T mutant (also associated with early onset PD).
Pssm-ID: 438014 [Multi-domain] Cd Length: 740 Bit Score: 40.34 E-value: 4.28e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
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