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Conserved domains on  [gi|149067372|gb|EDM17105|]
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MTERF domain containing 3, isoform CRA_a [Rattus norvegicus]

Protein Classification

mTERF domain-containing protein( domain architecture ID 139977)

mTERF (mitochondrial transcription termination factor) domain-containing protein may function as a transcription termination factor that binds promoter DNA and regulates mitochondrial replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
mTERF super family cl47744
mTERF; This family contains one sequence of known function Human mitochondrial transcription ...
 93-369 4.36e-12

mTERF; This family contains one sequence of known function Human mitochondrial transcription termination factor (mTERF) the rest of the family consists of hypothetical proteins none of which have any functional information. mTERF is a multizipper protein possessing three putative leucine zippers one of which is bipartite. The protein binds DNA as a monomer. The leucine zippers are not implicated in a dimerization role as in other leucine zippers.


The actual alignment was detected with superfamily member pfam02536:

Pssm-ID: 460581 [Multi-domain]  Cd Length: 313  Bit Score: 66.47  E-value: 4.36e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149067372   93 LKELGANQTVIASILERCPEAIVCS-PAAVNTKRKLWQMVCKTKTELIQLIEQFPEsFFAVKDQENQKLNVQFFQELGLK 171
Cdd:pfam02536  40 LLSLGASSSDLGKILSKYPRILGFKlEETMSTSVDFLKEIGVDKSSIGGALRSWPS-ILGMRVGNNIKNNVEYLRELGVP 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149067372  172 NVVITRFLTTASSI--FHNPVENNKQMIGVLLESYLNLGGSEANakVWllKLLSQNPFIVLSSPTA-VGEVLKFLQGQGF 248
Cdd:pfam02536 119 QKLLARLLISRPQLlaLDLVYLMKPKTFEEKVEFLKELGFSVED--VW--KIIKKCPEILGLSIEKkLKKKIEFLKKCGL 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149067372  249 TDSEVLQLLSKLKGFLfQLQPGSIQNSISFTKTtFECTDHDLRQLVVKCPALLYYPAPVLEERIQALLKE-GISVAQIRA 327
Cdd:pfam02536 195 SEEELPRVIKKYPQIL-SLSERTILNRVEFLLG-LGFSKEEVAKMVKRFPQLLGLSIEVLKPKLEFLVKEmKWPLKEVVE 272

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 149067372  328 SPMV----LELTpqiIQYRIRKLNSLGYgikDGHLAS-LNGTKKEFE 369
Cdd:pfam02536 273 YPRVfgysLEKR---IKPRIKALVSKGL---ECSLSWmLACSDERFL 313
 
Name Accession Description Interval E-value
mTERF pfam02536
mTERF; This family contains one sequence of known function Human mitochondrial transcription ...
 93-369 4.36e-12

mTERF; This family contains one sequence of known function Human mitochondrial transcription termination factor (mTERF) the rest of the family consists of hypothetical proteins none of which have any functional information. mTERF is a multizipper protein possessing three putative leucine zippers one of which is bipartite. The protein binds DNA as a monomer. The leucine zippers are not implicated in a dimerization role as in other leucine zippers.


Pssm-ID: 460581 [Multi-domain]  Cd Length: 313  Bit Score: 66.47  E-value: 4.36e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149067372   93 LKELGANQTVIASILERCPEAIVCS-PAAVNTKRKLWQMVCKTKTELIQLIEQFPEsFFAVKDQENQKLNVQFFQELGLK 171
Cdd:pfam02536  40 LLSLGASSSDLGKILSKYPRILGFKlEETMSTSVDFLKEIGVDKSSIGGALRSWPS-ILGMRVGNNIKNNVEYLRELGVP 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149067372  172 NVVITRFLTTASSI--FHNPVENNKQMIGVLLESYLNLGGSEANakVWllKLLSQNPFIVLSSPTA-VGEVLKFLQGQGF 248
Cdd:pfam02536 119 QKLLARLLISRPQLlaLDLVYLMKPKTFEEKVEFLKELGFSVED--VW--KIIKKCPEILGLSIEKkLKKKIEFLKKCGL 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149067372  249 TDSEVLQLLSKLKGFLfQLQPGSIQNSISFTKTtFECTDHDLRQLVVKCPALLYYPAPVLEERIQALLKE-GISVAQIRA 327
Cdd:pfam02536 195 SEEELPRVIKKYPQIL-SLSERTILNRVEFLLG-LGFSKEEVAKMVKRFPQLLGLSIEVLKPKLEFLVKEmKWPLKEVVE 272

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 149067372  328 SPMV----LELTpqiIQYRIRKLNSLGYgikDGHLAS-LNGTKKEFE 369
Cdd:pfam02536 273 YPRVfgysLEKR---IKPRIKALVSKGL---ECSLSWmLACSDERFL 313
PLN03196 PLN03196
MOC1-like protein; Provisional
 96-313 2.62e-03

MOC1-like protein; Provisional


Pssm-ID: 215628 [Multi-domain]  Cd Length: 487  Bit Score: 39.69  E-value: 2.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149067372  96 LGANQTVIASILERCPEaIVCSPAAVNTKRKLwQMVCK---TKTELIQLIEQFPEsFFAVKDQENQKLNVQFFQELGLKN 172
Cdd:PLN03196 206 IGVAPRDIGPMLTRFPE-ILGMRVGNNIKPKV-DYLESlglPRLAVARILEKRPY-ILGFDLEETVKPNVECLLEFGVRK 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149067372 173 VVITRFLTTASSIFHNPVENNKQMIGVLLESYLNLGgSEANAKVwllklLSQNPFIVLSSPTAVGEVLKFLQGQGFTDSE 252
Cdd:PLN03196 283 EALPSVIAQYPDILGLDLKAKLAEQQYWLTSKLKID-PEDFGRV-----IEKLPQIVSLNRNVALKHVEFLRGRGFSAQD 356

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 149067372 253 VLQLLSKLKGFLfQLQPGSIQNSISFTKTTFEctdhdlRQL--VVKCPALLYYPapvLEERIQ 313
Cdd:PLN03196 357 VAKMVVRCPQIL-ALNLEIMKPSLEFFKKEMK------RPLkeLVEFPAYFTYG---LESRIK 409
 
Name Accession Description Interval E-value
mTERF pfam02536
mTERF; This family contains one sequence of known function Human mitochondrial transcription ...
 93-369 4.36e-12

mTERF; This family contains one sequence of known function Human mitochondrial transcription termination factor (mTERF) the rest of the family consists of hypothetical proteins none of which have any functional information. mTERF is a multizipper protein possessing three putative leucine zippers one of which is bipartite. The protein binds DNA as a monomer. The leucine zippers are not implicated in a dimerization role as in other leucine zippers.


Pssm-ID: 460581 [Multi-domain]  Cd Length: 313  Bit Score: 66.47  E-value: 4.36e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149067372   93 LKELGANQTVIASILERCPEAIVCS-PAAVNTKRKLWQMVCKTKTELIQLIEQFPEsFFAVKDQENQKLNVQFFQELGLK 171
Cdd:pfam02536  40 LLSLGASSSDLGKILSKYPRILGFKlEETMSTSVDFLKEIGVDKSSIGGALRSWPS-ILGMRVGNNIKNNVEYLRELGVP 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149067372  172 NVVITRFLTTASSI--FHNPVENNKQMIGVLLESYLNLGGSEANakVWllKLLSQNPFIVLSSPTA-VGEVLKFLQGQGF 248
Cdd:pfam02536 119 QKLLARLLISRPQLlaLDLVYLMKPKTFEEKVEFLKELGFSVED--VW--KIIKKCPEILGLSIEKkLKKKIEFLKKCGL 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149067372  249 TDSEVLQLLSKLKGFLfQLQPGSIQNSISFTKTtFECTDHDLRQLVVKCPALLYYPAPVLEERIQALLKE-GISVAQIRA 327
Cdd:pfam02536 195 SEEELPRVIKKYPQIL-SLSERTILNRVEFLLG-LGFSKEEVAKMVKRFPQLLGLSIEVLKPKLEFLVKEmKWPLKEVVE 272

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 149067372  328 SPMV----LELTpqiIQYRIRKLNSLGYgikDGHLAS-LNGTKKEFE 369
Cdd:pfam02536 273 YPRVfgysLEKR---IKPRIKALVSKGL---ECSLSWmLACSDERFL 313
mTERF pfam02536
mTERF; This family contains one sequence of known function Human mitochondrial transcription ...
 87-170 6.41e-04

mTERF; This family contains one sequence of known function Human mitochondrial transcription termination factor (mTERF) the rest of the family consists of hypothetical proteins none of which have any functional information. mTERF is a multizipper protein possessing three putative leucine zippers one of which is bipartite. The protein binds DNA as a monomer. The leucine zippers are not implicated in a dimerization role as in other leucine zippers.


Pssm-ID: 460581 [Multi-domain]  Cd Length: 313  Bit Score: 41.43  E-value: 6.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149067372   87 EEIANILKELGANQTVIASILERCPEAIVCSPAAVNTKRKLWQMVCK-TKTELIQLIEQFPEsfFAVKDQENQKLNVQFF 165
Cdd:pfam02536 147 EEKVEFLKELGFSVEDVWKIIKKCPEILGLSIEKKLKKKIEFLKKCGlSEEELPRVIKKYPQ--ILSLSERTILNRVEFL 224


                  ....*
gi 149067372  166 QELGL 170
Cdd:pfam02536 225 LGLGF 229
PLN03196 PLN03196
MOC1-like protein; Provisional
 96-313 2.62e-03

MOC1-like protein; Provisional


Pssm-ID: 215628 [Multi-domain]  Cd Length: 487  Bit Score: 39.69  E-value: 2.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149067372  96 LGANQTVIASILERCPEaIVCSPAAVNTKRKLwQMVCK---TKTELIQLIEQFPEsFFAVKDQENQKLNVQFFQELGLKN 172
Cdd:PLN03196 206 IGVAPRDIGPMLTRFPE-ILGMRVGNNIKPKV-DYLESlglPRLAVARILEKRPY-ILGFDLEETVKPNVECLLEFGVRK 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149067372 173 VVITRFLTTASSIFHNPVENNKQMIGVLLESYLNLGgSEANAKVwllklLSQNPFIVLSSPTAVGEVLKFLQGQGFTDSE 252
Cdd:PLN03196 283 EALPSVIAQYPDILGLDLKAKLAEQQYWLTSKLKID-PEDFGRV-----IEKLPQIVSLNRNVALKHVEFLRGRGFSAQD 356

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 149067372 253 VLQLLSKLKGFLfQLQPGSIQNSISFTKTTFEctdhdlRQL--VVKCPALLYYPapvLEERIQ 313
Cdd:PLN03196 357 VAKMVVRCPQIL-ALNLEIMKPSLEFFKKEMK------RPLkeLVEFPAYFTYG---LESRIK 409
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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