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Conserved domains on  [gi|149068487|gb|EDM18039|]
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hemopexin, isoform CRA_f [Rattus norvegicus]

Protein Classification

HX domain-containing protein( domain architecture ID 10056662)

HX domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 228-417 4.68e-39

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


:

Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 138.98  E-value: 4.68e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149068487 228 RGATYAFSGSHYWRLDSSRDGWHSWPIAHHWPQGPSAVDAAFSW--DEKVYLIQGTQVYVFLtkgGNNLVSGYPKRLEKe 305
Cdd:cd00094   16 RGELYFFKGRYFWRLSPGKPPGSPFLISSFWPSLPSPVDAAFERpdTGKIYFFKGDKYWVYT---GKNLEPGYPKPISD- 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149068487 306 LGSPPgiSLDTIDAAFSCPGSSKLYVTSGRRLWWLDLKSGAQA------TWAELSWPHEKVDGALClekslgpyscsSNG 379
Cdd:cd00094   92 LGFPP--TVKQIDAALRWPDNGKTYFFKGDKYWRYDEKTQKMDpgypklIETDFPGVPDKVDAAFR-----------WLD 158

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 149068487 380 PNLFFIHGPNLYCYSSIDKLNaakSLPQPQKVNS-ILGC 417
Cdd:cd00094  159 GYYYFFKGDQYWRFDPRSKEV---RVGYPLKISSdWLGC 194
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 51-189 4.25e-34

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


:

Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 125.89  E-value: 4.25e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149068487  51 SDAW-----SLDAAFRGP--DSVFLIKEDKVWVYPPEKKENGYPKLFQEeFPGIPYPP--DAAVECHRGEcqseGVLFFQ 121
Cdd:cd00094   43 SSFWpslpsPVDAAFERPdtGKIYFFKGDKYWVYTGKNLEPGYPKPISD-LGFPPTVKqiDAALRWPDNG----KTYFFK 117

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 149068487 122 GNRKWFWDFATRTQK-------ERSWPAVGN-CTAALRWL-ERYYCFQGNKFLRFNPVTGEVPPRYPLDARDYFISC 189
Cdd:cd00094  118 GDKYWRYDEKTQKMDpgypkliETDFPGVPDkVDAAFRWLdGYYYFFKGDQYWRFDPRSKEVRVGYPLKISSDWLGC 194
 
Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 228-417 4.68e-39

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 138.98  E-value: 4.68e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149068487 228 RGATYAFSGSHYWRLDSSRDGWHSWPIAHHWPQGPSAVDAAFSW--DEKVYLIQGTQVYVFLtkgGNNLVSGYPKRLEKe 305
Cdd:cd00094   16 RGELYFFKGRYFWRLSPGKPPGSPFLISSFWPSLPSPVDAAFERpdTGKIYFFKGDKYWVYT---GKNLEPGYPKPISD- 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149068487 306 LGSPPgiSLDTIDAAFSCPGSSKLYVTSGRRLWWLDLKSGAQA------TWAELSWPHEKVDGALClekslgpyscsSNG 379
Cdd:cd00094   92 LGFPP--TVKQIDAALRWPDNGKTYFFKGDKYWRYDEKTQKMDpgypklIETDFPGVPDKVDAAFR-----------WLD 158

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 149068487 380 PNLFFIHGPNLYCYSSIDKLNaakSLPQPQKVNS-ILGC 417
Cdd:cd00094  159 GYYYFFKGDQYWRFDPRSKEV---RVGYPLKISSdWLGC 194
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 51-189 4.25e-34

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 125.89  E-value: 4.25e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149068487  51 SDAW-----SLDAAFRGP--DSVFLIKEDKVWVYPPEKKENGYPKLFQEeFPGIPYPP--DAAVECHRGEcqseGVLFFQ 121
Cdd:cd00094   43 SSFWpslpsPVDAAFERPdtGKIYFFKGDKYWVYTGKNLEPGYPKPISD-LGFPPTVKqiDAALRWPDNG----KTYFFK 117

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 149068487 122 GNRKWFWDFATRTQK-------ERSWPAVGN-CTAALRWL-ERYYCFQGNKFLRFNPVTGEVPPRYPLDARDYFISC 189
Cdd:cd00094  118 GDKYWRYDEKTQKMDpgypkliETDFPGVPDkVDAAFRWLdGYYYFFKGDQYWRFDPRSKEVRVGYPLKISSDWLGC 194
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 56-98 5.25e-06

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 43.00  E-value: 5.25e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 149068487    56 LDAAFRGPDS-VFLIKEDKVWVYPPEKKENGYPKLFQEEFPGIP 98
Cdd:smart00120   1 IDAAFELRDGkTYFFKGDKYWRFDPKRVDPGYPKLISSFFPGLP 44
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 220-263 2.16e-05

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 41.46  E-value: 2.16e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 149068487   220 LSALLSDHRGATYAFSGSHYWRLDSSR-DGWHSWPIAHHWPQGPS 263
Cdd:smart00120   1 IDAAFELRDGKTYFFKGDKYWRFDPKRvDPGYPKLISSFFPGLPC 45
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 56-98 9.53e-05

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 39.47  E-value: 9.53e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 149068487   56 LDAAFR-GPDSVFLIKEDKVWVYPPEKKENGYPKLFqEEFPGIP 98
Cdd:pfam00045   1 IDAAFEdRDGKTYFFKGRKYWRFDPQRVEPGYPKLI-SDFPGLP 43
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 220-263 1.75e-03

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 36.01  E-value: 1.75e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 149068487  220 LSALLSDHRGATYAFSGSHYWRLDSSR-DGWHSWPIAhHWPQGPS 263
Cdd:pfam00045   1 IDAAFEDRDGKTYFFKGRKYWRFDPQRvEPGYPKLIS-DFPGLPC 44
 
Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 228-417 4.68e-39

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 138.98  E-value: 4.68e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149068487 228 RGATYAFSGSHYWRLDSSRDGWHSWPIAHHWPQGPSAVDAAFSW--DEKVYLIQGTQVYVFLtkgGNNLVSGYPKRLEKe 305
Cdd:cd00094   16 RGELYFFKGRYFWRLSPGKPPGSPFLISSFWPSLPSPVDAAFERpdTGKIYFFKGDKYWVYT---GKNLEPGYPKPISD- 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149068487 306 LGSPPgiSLDTIDAAFSCPGSSKLYVTSGRRLWWLDLKSGAQA------TWAELSWPHEKVDGALClekslgpyscsSNG 379
Cdd:cd00094   92 LGFPP--TVKQIDAALRWPDNGKTYFFKGDKYWRYDEKTQKMDpgypklIETDFPGVPDKVDAAFR-----------WLD 158

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 149068487 380 PNLFFIHGPNLYCYSSIDKLNaakSLPQPQKVNS-ILGC 417
Cdd:cd00094  159 GYYYFFKGDQYWRFDPRSKEV---RVGYPLKISSdWLGC 194
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 51-189 4.25e-34

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 125.89  E-value: 4.25e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149068487  51 SDAW-----SLDAAFRGP--DSVFLIKEDKVWVYPPEKKENGYPKLFQEeFPGIPYPP--DAAVECHRGEcqseGVLFFQ 121
Cdd:cd00094   43 SSFWpslpsPVDAAFERPdtGKIYFFKGDKYWVYTGKNLEPGYPKPISD-LGFPPTVKqiDAALRWPDNG----KTYFFK 117

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 149068487 122 GNRKWFWDFATRTQK-------ERSWPAVGN-CTAALRWL-ERYYCFQGNKFLRFNPVTGEVPPRYPLDARDYFISC 189
Cdd:cd00094  118 GDKYWRYDEKTQKMDpgypkliETDFPGVPDkVDAAFRWLdGYYYFFKGDQYWRFDPRSKEVRVGYPLKISSDWLGC 194
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 56-98 5.25e-06

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 43.00  E-value: 5.25e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 149068487    56 LDAAFRGPDS-VFLIKEDKVWVYPPEKKENGYPKLFQEEFPGIP 98
Cdd:smart00120   1 IDAAFELRDGkTYFFKGDKYWRFDPKRVDPGYPKLISSFFPGLP 44
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 220-263 2.16e-05

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 41.46  E-value: 2.16e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 149068487   220 LSALLSDHRGATYAFSGSHYWRLDSSR-DGWHSWPIAHHWPQGPS 263
Cdd:smart00120   1 IDAAFELRDGKTYFFKGDKYWRFDPKRvDPGYPKLISSFFPGLPC 45
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 56-98 9.53e-05

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 39.47  E-value: 9.53e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 149068487   56 LDAAFR-GPDSVFLIKEDKVWVYPPEKKENGYPKLFqEEFPGIP 98
Cdd:pfam00045   1 IDAAFEdRDGKTYFFKGRKYWRFDPQRVEPGYPKLI-SDFPGLP 43
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 220-263 1.75e-03

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 36.01  E-value: 1.75e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 149068487  220 LSALLSDHRGATYAFSGSHYWRLDSSR-DGWHSWPIAhHWPQGPS 263
Cdd:pfam00045   1 IDAAFEDRDGKTYFFKGRKYWRFDPQRvEPGYPKLIS-DFPGLPC 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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