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Conserved domains on  [gi|167666312|gb|EDS10442|]
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bacterial stress protein [Anaerotruncus colihominis DSM 17241]

Protein Classification

vWA domain-containing protein( domain architecture ID 10161394)

vWA (von Willebrand factor type A) domain-containing protein may be involved in one of a wide variety of important cellular functions, including basal membrane formation, cell migration, cell differentiation, adhesion, hemostasis, signaling, chromosomal stability, malignant transformation, and immune defenses

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
vWFA super family cl00057
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ...
 270-459 6.32e-53

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.


The actual alignment was detected with superfamily member pfam10138:

Pssm-ID: 469594 [Multi-domain]  Cd Length: 200  Bit Score: 176.71  E-value: 6.32e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167666312  270 VVMCSDISGSMFDQYRNGRMQRVVDKFFTYASTLSDAATMDFWAFAAKSRQFGAVTMDNVRDYTFAEMGGFERWMSMLNY 349
Cdd:pfam10138   4 VGLVLDASGSMSGLYRRGTVQRVVERMLPVAAQLDDDGELDVWLFGTRAARLPDVTLADLPGWVERLHLGRDRYRKLGGQ 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167666312  350 qfNNEPEAMRDIMMIY--GGLRAPVMVLFVTDGHLSADWAIEEILIKTSRFPIFWQFIGIGGSEYGILSCLNEIDGRHSN 427
Cdd:pfam10138  84 --NNEPPVMEAVIDYYrkNPADLPTLVLFITDGGVTDNAAIERLLREASREPIFWQFVGIGRSGYGFLEKLDTLRGRVVD 161

                         170       180       190
                  ....*....|....*....|....*....|..
gi 167666312  428 NAAFLKLEDIDDLSDQALFQELLCNLEQWLNE 459
Cdd:pfam10138 162 NAGFFALDDIDRVSDAELYDRLLSEFPDWLRA 193
TerD_like cd06974
Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; ...
 28-170 1.34e-45

Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Tellurium resistance terD like proteins. This family is composed of uncharacterized proteins involved in stress response, such as the tellurium resistance proteins, chemical-damaging agent resistance proteins, and general stress proteins from a variety of organisms. The tellurium resistance proteins are homologous terA,-D,-E,-F,-Z,-X gene products, which confer tellurium resistance mediated by plasmids. Currently, the biochemical mechanism of tellurium resistance remains unknown. The family also contains several ter gene homologues, YceC, YceD, YceE, for which there is no clear evidence for any involvement in the tellurium resistance. A putative cAMP-binding protin CABP1 shows a significant similarity to the terD protein and is also included in this family.


:

Pssm-ID: 132992  Cd Length: 162  Bit Score: 156.30  E-value: 1.34e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167666312  28 KAPMELDVACFGLDSAGRLSDEQYFVFYNQKQSPEQAVCLSAGVATGS----ERFTLSLGKLPSKISKLSFAVSIDGTHT 103
Cdd:cd06974   16 GGGIDLDLSAFLLDADGKVRGDADVVFYNQLSSPDGAVRLSGDNRTGGdgddETITVDLDRLPPDIRRIVFTVTIYEGQP 95

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 167666312 104 MRELEKGYVRLLSGQTEMLRFSYSGAEFSGERAIVICEIYRKGDDWRFCAVGRGFNGGLKALIESYG 170
Cdd:cd06974   96 FGQVENAFVRLVDAGGNTELARYDLTEDSGETALILAELYRRNGEWKFRAVGQGFNGGLAALATHYG 162
 
Name Accession Description Interval E-value
vWA-TerF-like pfam10138
vWA found in TerF C terminus; vWA domain fused to TerD domain typified by the TerF protein. ...
 270-459 6.32e-53

vWA found in TerF C terminus; vWA domain fused to TerD domain typified by the TerF protein. Some times found as solos.


Pssm-ID: 401947 [Multi-domain]  Cd Length: 200  Bit Score: 176.71  E-value: 6.32e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167666312  270 VVMCSDISGSMFDQYRNGRMQRVVDKFFTYASTLSDAATMDFWAFAAKSRQFGAVTMDNVRDYTFAEMGGFERWMSMLNY 349
Cdd:pfam10138   4 VGLVLDASGSMSGLYRRGTVQRVVERMLPVAAQLDDDGELDVWLFGTRAARLPDVTLADLPGWVERLHLGRDRYRKLGGQ 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167666312  350 qfNNEPEAMRDIMMIY--GGLRAPVMVLFVTDGHLSADWAIEEILIKTSRFPIFWQFIGIGGSEYGILSCLNEIDGRHSN 427
Cdd:pfam10138  84 --NNEPPVMEAVIDYYrkNPADLPTLVLFITDGGVTDNAAIERLLREASREPIFWQFVGIGRSGYGFLEKLDTLRGRVVD 161

                         170       180       190
                  ....*....|....*....|....*....|..
gi 167666312  428 NAAFLKLEDIDDLSDQALFQELLCNLEQWLNE 459
Cdd:pfam10138 162 NAGFFALDDIDRVSDAELYDRLLSEFPDWLRA 193
TerD_like cd06974
Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; ...
 28-170 1.34e-45

Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Tellurium resistance terD like proteins. This family is composed of uncharacterized proteins involved in stress response, such as the tellurium resistance proteins, chemical-damaging agent resistance proteins, and general stress proteins from a variety of organisms. The tellurium resistance proteins are homologous terA,-D,-E,-F,-Z,-X gene products, which confer tellurium resistance mediated by plasmids. Currently, the biochemical mechanism of tellurium resistance remains unknown. The family also contains several ter gene homologues, YceC, YceD, YceE, for which there is no clear evidence for any involvement in the tellurium resistance. A putative cAMP-binding protin CABP1 shows a significant similarity to the terD protein and is also included in this family.


Pssm-ID: 132992  Cd Length: 162  Bit Score: 156.30  E-value: 1.34e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167666312  28 KAPMELDVACFGLDSAGRLSDEQYFVFYNQKQSPEQAVCLSAGVATGS----ERFTLSLGKLPSKISKLSFAVSIDGTHT 103
Cdd:cd06974   16 GGGIDLDLSAFLLDADGKVRGDADVVFYNQLSSPDGAVRLSGDNRTGGdgddETITVDLDRLPPDIRRIVFTVTIYEGQP 95

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 167666312 104 MRELEKGYVRLLSGQTEMLRFSYSGAEFSGERAIVICEIYRKGDDWRFCAVGRGFNGGLKALIESYG 170
Cdd:cd06974   96 FGQVENAFVRLVDAGGNTELARYDLTEDSGETALILAELYRRNGEWKFRAVGQGFNGGLAALATHYG 162
TerD pfam02342
TerD domain; The TerD domain is found in TerD family proteins that include the paralogous TerD, ...
 29-169 3.83e-44

TerD domain; The TerD domain is found in TerD family proteins that include the paralogous TerD, TerA, TerE, TerF and TerZ proteins It is found in a stress response operon with TerB and TerC. TerD has a maximum of two calcium-binding sites depending on the conservation of aspartates. It has various fusions to nuclease domains, RNA binding domains, ubiquitin related domains, and metal binding domains. The ter gene products lie at the centre of membrane-linked metal recognition complexes with regulatory ramifications encompassing phosphorylation-dependent signal transduction, RNA-dependent regulation, biosynthesis of nucleoside-like metabolites and DNA processing linked to novel pathways.


Pssm-ID: 426730  Cd Length: 187  Bit Score: 153.04  E-value: 3.83e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167666312   29 APMELDVACFGLDSAGRLSDEQYFVFYNQKQSPEQAVCLSAGVATGS-----ERFTLSLGKLPSKISKLSFAVSIDGT-- 101
Cdd:pfam02342  37 ADFDLDASAFLLGANGKVRSDEDFVFYNNLKSPDGSVRHLGDNLTGEgdgddEQIEVDLSKVPADVEKIVFVVTIYDAea 116

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 167666312  102 --HTMRELEKGYVRLL--SGQTEMLRFSYSgAEFSGERAIVICEIYRKGDDWRFCAVGRGFNGGLKALIESY 169
Cdd:pfam02342 117 rrQNFGQVRNAYIRVVdaATGEELARYDLS-EDFSGETALIFGELYRHGGEWKFRAVGQGYAGGLAGLATDY 187
TerZ COG2310
Stress response protein SCP2 [Signal transduction mechanisms];
26-169 8.70e-37

Stress response protein SCP2 [Signal transduction mechanisms];


Pssm-ID: 441884  Cd Length: 187  Bit Score: 133.37  E-value: 8.70e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167666312  26 YHKAPMELDVACFGLDSAGRLSDEQYFVFYNQKQSPEQAVCLSAGVATG-----SERFTLSLGKLPSKISKLSFAVSIDG 100
Cdd:COG2310   34 TDGGDFDLDASAFLLDANGKVRSDEDFVFYNNLKSPDGSVRHTGDNRTGegdgdDEQITVDLSKVPADVEKIVFVVTIYD 113

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 167666312 101 T----HTMRELEKGYVRLLSGQT--EMLRFSYSgAEFSGERAIVICEIYRKGDDWRFCAVGRGFNGGLKALIESY 169
Cdd:COG2310  114 AeargQNFGQVSNAFIRVVDAATgeELARYDLS-EDFSGETAMVFGELYRHGGEWKFRAVGQGYNGGLAGLATDY 187
 
Name Accession Description Interval E-value
vWA-TerF-like pfam10138
vWA found in TerF C terminus; vWA domain fused to TerD domain typified by the TerF protein. ...
 270-459 6.32e-53

vWA found in TerF C terminus; vWA domain fused to TerD domain typified by the TerF protein. Some times found as solos.


Pssm-ID: 401947 [Multi-domain]  Cd Length: 200  Bit Score: 176.71  E-value: 6.32e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167666312  270 VVMCSDISGSMFDQYRNGRMQRVVDKFFTYASTLSDAATMDFWAFAAKSRQFGAVTMDNVRDYTFAEMGGFERWMSMLNY 349
Cdd:pfam10138   4 VGLVLDASGSMSGLYRRGTVQRVVERMLPVAAQLDDDGELDVWLFGTRAARLPDVTLADLPGWVERLHLGRDRYRKLGGQ 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167666312  350 qfNNEPEAMRDIMMIY--GGLRAPVMVLFVTDGHLSADWAIEEILIKTSRFPIFWQFIGIGGSEYGILSCLNEIDGRHSN 427
Cdd:pfam10138  84 --NNEPPVMEAVIDYYrkNPADLPTLVLFITDGGVTDNAAIERLLREASREPIFWQFVGIGRSGYGFLEKLDTLRGRVVD 161

                         170       180       190
                  ....*....|....*....|....*....|..
gi 167666312  428 NAAFLKLEDIDDLSDQALFQELLCNLEQWLNE 459
Cdd:pfam10138 162 NAGFFALDDIDRVSDAELYDRLLSEFPDWLRA 193
TerD_like cd06974
Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; ...
 28-170 1.34e-45

Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Tellurium resistance terD like proteins. This family is composed of uncharacterized proteins involved in stress response, such as the tellurium resistance proteins, chemical-damaging agent resistance proteins, and general stress proteins from a variety of organisms. The tellurium resistance proteins are homologous terA,-D,-E,-F,-Z,-X gene products, which confer tellurium resistance mediated by plasmids. Currently, the biochemical mechanism of tellurium resistance remains unknown. The family also contains several ter gene homologues, YceC, YceD, YceE, for which there is no clear evidence for any involvement in the tellurium resistance. A putative cAMP-binding protin CABP1 shows a significant similarity to the terD protein and is also included in this family.


Pssm-ID: 132992  Cd Length: 162  Bit Score: 156.30  E-value: 1.34e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167666312  28 KAPMELDVACFGLDSAGRLSDEQYFVFYNQKQSPEQAVCLSAGVATGS----ERFTLSLGKLPSKISKLSFAVSIDGTHT 103
Cdd:cd06974   16 GGGIDLDLSAFLLDADGKVRGDADVVFYNQLSSPDGAVRLSGDNRTGGdgddETITVDLDRLPPDIRRIVFTVTIYEGQP 95

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 167666312 104 MRELEKGYVRLLSGQTEMLRFSYSGAEFSGERAIVICEIYRKGDDWRFCAVGRGFNGGLKALIESYG 170
Cdd:cd06974   96 FGQVENAFVRLVDAGGNTELARYDLTEDSGETALILAELYRRNGEWKFRAVGQGFNGGLAALATHYG 162
TerD pfam02342
TerD domain; The TerD domain is found in TerD family proteins that include the paralogous TerD, ...
 29-169 3.83e-44

TerD domain; The TerD domain is found in TerD family proteins that include the paralogous TerD, TerA, TerE, TerF and TerZ proteins It is found in a stress response operon with TerB and TerC. TerD has a maximum of two calcium-binding sites depending on the conservation of aspartates. It has various fusions to nuclease domains, RNA binding domains, ubiquitin related domains, and metal binding domains. The ter gene products lie at the centre of membrane-linked metal recognition complexes with regulatory ramifications encompassing phosphorylation-dependent signal transduction, RNA-dependent regulation, biosynthesis of nucleoside-like metabolites and DNA processing linked to novel pathways.


Pssm-ID: 426730  Cd Length: 187  Bit Score: 153.04  E-value: 3.83e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167666312   29 APMELDVACFGLDSAGRLSDEQYFVFYNQKQSPEQAVCLSAGVATGS-----ERFTLSLGKLPSKISKLSFAVSIDGT-- 101
Cdd:pfam02342  37 ADFDLDASAFLLGANGKVRSDEDFVFYNNLKSPDGSVRHLGDNLTGEgdgddEQIEVDLSKVPADVEKIVFVVTIYDAea 116

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 167666312  102 --HTMRELEKGYVRLL--SGQTEMLRFSYSgAEFSGERAIVICEIYRKGDDWRFCAVGRGFNGGLKALIESY 169
Cdd:pfam02342 117 rrQNFGQVRNAYIRVVdaATGEELARYDLS-EDFSGETALIFGELYRHGGEWKFRAVGQGYAGGLAGLATDY 187
TerZ COG2310
Stress response protein SCP2 [Signal transduction mechanisms];
26-169 8.70e-37

Stress response protein SCP2 [Signal transduction mechanisms];


Pssm-ID: 441884  Cd Length: 187  Bit Score: 133.37  E-value: 8.70e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167666312  26 YHKAPMELDVACFGLDSAGRLSDEQYFVFYNQKQSPEQAVCLSAGVATG-----SERFTLSLGKLPSKISKLSFAVSIDG 100
Cdd:COG2310   34 TDGGDFDLDASAFLLDANGKVRSDEDFVFYNNLKSPDGSVRHTGDNRTGegdgdDEQITVDLSKVPADVEKIVFVVTIYD 113

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 167666312 101 T----HTMRELEKGYVRLLSGQT--EMLRFSYSgAEFSGERAIVICEIYRKGDDWRFCAVGRGFNGGLKALIESY 169
Cdd:COG2310  114 AeargQNFGQVSNAFIRVVDAATgeELARYDLS-EDFSGETAMVFGELYRHGGEWKFRAVGQGYNGGLAGLATDY 187
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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