|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
31-478 |
1.39e-70 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 228.98 E-value: 1.39e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 31 LGFFAFMTNLDGSIVNIAVPIMAKDLKVPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIFKWGTGTFVLGSLMAGI 110
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 111 NLGFNFLMLARMIQALGGAMTLANTYGIVTSTFALAERGRAMGVVSTFVALGGVAGPSLGGLILAHFSWPMIFLINVPIG 190
Cdd:cd17321 81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 191 LIALGVSlwsmnngipqrgtydgwgmilqataiasgfwglnlaqqsgfddpvvlstlalavvaliafigfeqrqqapllp 270
Cdd:cd17321 161 LVALLLA------------------------------------------------------------------------- 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 271 lrifrvRIFTLGVVTVFFIFMVQFFSTVLMPFYLEDARGLTPGTAGTLLSLYPLMMVFFAPFGGWLADKWNVPAVALLGS 350
Cdd:cd17321 168 ------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGL 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 351 IFIAVGSLIGATLKSNAPLTIYIISTLLVGIGSGLFQSPIGDVVMSVVPKNQLGIAGSFNALARNLGMVSGTAVATTVLF 430
Cdd:cd17321 242 LLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLT 321
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 227189595 431 GTMS-QLAGSRVTNYPTAHPEFFISGLQVAMIVAAVLAILGAIAIGLTI 478
Cdd:cd17321 322 AGLSaNLGDSGVAALLSAAAAAFAAGFHLAFLVAAALALLAALLALLLP 370
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
27-434 |
2.37e-55 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 192.21 E-value: 2.37e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 27 LLVALGFFAFMTNLDGSIVNIAVPIMAKDLKVPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIFKWGTGTFVLGSL 106
Cdd:TIGR00711 3 LTIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 107 MAGINLGFNFLMLARMIQALGGAMTLANTYGIVTSTFALAERGRAMGVVSTFVALGGVAGPSLGGLILAHFSWPMIFLIN 186
Cdd:TIGR00711 83 LCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLIN 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 187 VPIGLIALGVSLWSMNNGIP-QRGTYDGWGMILQATAIASGFWGLNLAQQSG-FDDPVVLSTLALAVVALIAFIGFEQRQ 264
Cdd:TIGR00711 163 VPIGIIVVVVAFFILPRDKPaASENFDFLGLLLLSVGLGSLLYGLSEGPERGwFDSNEILILSITGLVAIIAFVVWELTD 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 265 QAPLLPLRIFRVRIFTLGVVTVFFIFMVQFFSTVLMPFYLEDARGLTPGTAGTLLSLYPLMMVFFAPFGGWLADKWNVPA 344
Cdd:TIGR00711 243 DNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRK 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 345 VALLGSIFIAVGS-LIGATLKSNAPLTIYIISTLLVGIGSGLFQSPIGDVVMSVVPKNQLGIAGSFNALARNLGMVSGTA 423
Cdd:TIGR00711 323 LVTIGLILYAVGFyWRAFTFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGTA 402
|
410
....*....|.
gi 227189595 424 VATTVLFGTMS 434
Cdd:TIGR00711 403 LITTILTNRTQ 413
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
35-474 |
3.25e-53 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 183.55 E-value: 3.25e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 35 AFMTNLDGSIVNIAVPIMAKDLKVPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIFKWGTGTFVLGSLMAGINLGF 114
Cdd:cd17503 5 AFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 115 NFLMLARMIQALGGAMTLANTYGIVTSTFALAERGRAMGVVSTFVALGGVAGPSLGGLILAHFSWPMIFLINVPIGLIAL 194
Cdd:cd17503 85 ASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILAL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 195 GVslwsmnngipqrgtydgwgmilqataiasgfwglnlaqqsgfddpvvlstlalavvaliafigfeqrqqAPLLPLRIF 274
Cdd:cd17503 165 LL---------------------------------------------------------------------APLLDLRLF 175
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 275 RVRIFTLGVVTVFFIFMVQFFSTVLMPFYLEDARGLTPGTAGTLLSLYPLMMVFFAPFGGWLADKWNVPAVALLGSIFIA 354
Cdd:cd17503 176 KDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLA 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 355 VGSLIGATLKSNAPLTIYIISTLLVGIGSGLFQSPIGDVVMSVVPKNQLGIAGSFNALARNLGMVSGTAVATTVL-FGTM 433
Cdd:cd17503 256 LGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLtNRTQ 335
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 227189595 434 SQLAGSRVTNYPTAHPEFFISGLQVAMIVAAVLAILGAIAI 474
Cdd:cd17503 336 FHHSRLSELLAQQVQKQALIIAFNDAFLVSAILLLVGLLLA 376
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
18-418 |
1.75e-38 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 143.19 E-value: 1.75e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 18 SETAPKRWWLLVALGFFAFMTNLDGSIVNIAVPIMAKDLKVPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIFKWG 97
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 98 TGTFVLGSLMAGINLGFNFLMLARMIQALGGAMTLANTYGIVTSTFALAERGRAMGVVSTFVALGGVAGPSLGGLILAHF 177
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 178 SWPMIFLINVPIGLIALGVSLWSMNNGIPQRgtydgwgmilqataiasgfwglnlaqqsgfddpvvlstlalavvaliaf 257
Cdd:COG2814 162 GWRWVFLVNAVLALLALLLLLRLLPESRPAA------------------------------------------------- 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 258 igfeqRQQAPLLPLRIFRVRIFTLGVVTVFFIFMVQFFSTVLMPFYLEDARGLTPGTAGTLLSLYPLMMVFFAPFGGWLA 337
Cdd:COG2814 193 -----RARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLA 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 338 DKWNVPAVALLGSIFIAVGSLIGATLksnAPLTIYIISTLLVGIGSGLFQSPIGDVVMSVVPKNQLGIAGSFNALARNLG 417
Cdd:COG2814 268 DRFGRRRLLLIGLLLLALGLLLLALA---GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
|
.
gi 227189595 418 M 418
Cdd:COG2814 345 G 345
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
23-450 |
5.09e-35 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 136.78 E-value: 5.09e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 23 KRWWLLVALGFFAFMTNLDGSIVNIAVPIMAKDLKVPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIFKWGTGTFV 102
Cdd:PRK14995 3 RQWLTLVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 103 LGSLMAGINLGFNFLMLARMIQALGGAMTLANTYGIVTSTFALA-ERGRAMGVVSTFVALGGVAGPSLGGLILAHFSWPM 181
Cdd:PRK14995 83 LASLAAAFSPTASWLIATRALLAIGAAMIVPATLAGIRATFTEEkQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGS 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 182 IFLINVPIGLIALGVSLWSmnngIP-QRGTYDGWGMILQATAIASGFWGLNLAQQSGFDDPVVLSTLALAVVA----LIA 256
Cdd:PRK14995 163 VFLINVPIVLVVMGLTARY----VPrQAGRRDQPLNLGHALMLIVAILLLVYSAKTALKGFLSLWVTSLTLLTgallLGL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 257 FIGFEQRQQAPLLPLRIFRVRIFTLGVV--TVFFIFMVQFfsTVLMPFYLEDARGLTPGTAGtlLSLYPLMMV--FFAPF 332
Cdd:PRK14995 239 FIRTQLAASRPMIDMRLFTHRIILSGVVmaMTAMITLVGF--ELLMAQELQFVHGLSPLEAG--MFMLPVMVAsgFSGPI 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 333 GGWLADKWNVPAVALLGSIFIAVgSLIGATLK--SNAPLTIYIISTLL-VGIGSGLFQSPigDVVMSVVPKNQLGIAGSF 409
Cdd:PRK14995 315 AGILVSRLGLRLVATGGMALSAL-SFYGLAMTdfSTQQWQAWGLMALLgFSAASALLAST--SAIMAAAPPEKAAAAGAI 391
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 227189595 410 NALARNLGMVSGTAvattvLFGTMSQLAGSRVTNYPTAHPE 450
Cdd:PRK14995 392 ETMAYELGAGLGIA-----IFGLLLSRSYSASIRLPAGLPA 427
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
36-432 |
5.53e-35 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 133.46 E-value: 5.53e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 36 FMTNLDGSIVNIAVPIMAKDLKvPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIFKWGTGTFVLGSLMAGINLGFN 115
Cdd:cd17502 6 FLAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMT 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 116 FLMLARMIQALGGAMTLANTYGIVTSTFALAERGRAMGVVSTFVALGGVAGPSLGGLILAHFSWPMIFLINVPIGLIALg 195
Cdd:cd17502 85 MLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGGLAL- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 196 vslwsmnngipqrgtydgwgmilqataiasgfwglnlaqqsgfddpvvlstlalavvaliafigfeqrqqapllplriFR 275
Cdd:cd17502 164 ------------------------------------------------------------------------------AL 165
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 276 VRIFTLGVVTVFFIFMVQFFSTVLMPFYLEDARGLTPGTAGTLLSLYPLMMVFFAPFGGWLADKW-NVPAVALLGSIFIA 354
Cdd:cd17502 166 LRTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTgRYKPLIVIGTILMS 245
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 227189595 355 VGSLIGATLKSNAPLTIYIISTLLVGIGSGLFQSPIGDVVMSVVPKNQLGIAGSFNALARNLGMVSGTAVATTVLFGT 432
Cdd:cd17502 246 VGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAITDVFLVAL 323
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
31-473 |
7.70e-31 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 122.69 E-value: 7.70e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 31 LGFFAFMTNLDGSIVNIAVPIMAKDLKVPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIFKWGTGTFVLGSLMAGI 110
Cdd:cd17504 1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 111 NLGFNFLMLARMIQALGGAMtLANTYGIVTSTFALAERGRAMGVVSTFVALGGVAGPSLGGLILAHFSWPMIFLINVPIG 190
Cdd:cd17504 81 APNLPVLIAGRALQGIGGAV-FPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 191 LIALGVslwsmnngipqrgtydgwgmilqataiasgfwglnlaqqsgfddpvvlstlalavvaliafigfeqrqqAPLLP 270
Cdd:cd17504 160 VLLAAL---------------------------------------------------------------------VPLID 170
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 271 LRIFRVRIFTLGVVTVFFIFMVQFFSTVLMPFYLEDARGLTPG----TAGTLLSLYPLMMVFFAPFGGWLADKWNVPAVA 346
Cdd:cd17504 171 LRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTPTGFGlgitEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVL 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 347 LLGSIFIAVGSLIGATLKSNapLTIYIISTLLVGIGSGLFQSPIGDVVMSVVPKNQLGIAGSFNALARNLGMVSGTAVAT 426
Cdd:cd17504 251 LIGLVISAVGLLLLALLHSS--LWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAG 328
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 227189595 427 TVlfgtmsqLAGSRVTNYPTAHPEFfiSGLQVAMIVAAVLAILGAIA 473
Cdd:cd17504 329 AI-------LTTYTVSITSGGVPTE--GAYVLAFLIGAALALAALLL 366
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
16-300 |
3.93e-29 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 116.06 E-value: 3.93e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 16 QRSETAPKRWWLLVALGFFAFMTNLDGSIVNIAVPIMAKDLKVPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIFK 95
Cdd:COG0477 4 TDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 96 WGTGTFVLGSLMAGINLGFNFLMLARMIQALGGAMTLANTYGIVTSTFALAERGRAMGVVSTFVALGGVAGPSLGGLILA 175
Cdd:COG0477 84 IGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 176 HFSWPMIFLINVPIGLIALGV------SLWSMNNGIPQRGTYDGWGMILQATAIASGFWGLNLAQQSGFDDPVVLSTLAL 249
Cdd:COG0477 164 ALGWRWIFLINAPLGLLALVLrlrlpeSRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLL 243
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 227189595 250 AVVALIAFIGFEQRQQAPLLPLRIFRVRIFTLGVVTVFFIFMVQFFSTVLM 300
Cdd:COG0477 244 ALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALL 294
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
24-327 |
5.46e-29 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 119.07 E-value: 5.46e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 24 RWWL-LVALGFFafMTNLDGSIVNIAVPIMAKDLKVPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIFKWGTGTFV 102
Cdd:PRK10504 9 RWQLwIVAFGFF--MQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFT 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 103 LGSLMAGINLGFNFLMLARMIQALGGAMTLANTYGIVTSTFALAERGRAMGVVSTFVALGGVAGPSLGGLILAHFSWPMI 182
Cdd:PRK10504 87 LGSLFCALSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWI 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 183 FLINVPIGLIALGVSLWSMNNGIPQRGTYDGWGMILQATAIASGFWGLNLAQQSGFDDPVVLSTLALAVVALIAFIGFEQ 262
Cdd:PRK10504 167 FLINIPVGIIGAIATLMLMPNYTMQTRRFDLSGFLLLAVGMATLTLALDGSKGLGLSPLAIAGLVAVGVVALLLYLLHAR 246
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 227189595 263 RQQAPLLPLRIFRVRIFTLGVVTVFFIFMVQFFSTVLMPFYLEDARGLTPGTAGtllslypLMMV 327
Cdd:PRK10504 247 NNNRALFSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAG-------LMMI 304
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
35-421 |
2.35e-27 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 113.05 E-value: 2.35e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 35 AFMTNLDGSIVNIAVPIMAKDLKVPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIFKWGTGTFVLGSLMAGINLGF 114
Cdd:cd17325 5 LFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSY 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 115 NFLMLARMIQALGGAMTLANTYGIVTSTFALAERGRAMGVVSTFVALGGVAGPSLGGLILAHFSWPMIFLINVPIGLIAL 194
Cdd:cd17325 85 WQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLAL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 195 GVSLWSMNNGIPQRGTYDGWGMILQATAIasgfwglnlaqqsgfddpvvlstlalavvaliafigfeqrqqapllpLRIF 274
Cdd:cd17325 165 VLALLLLPEPRPPPNKRAVSAARLRSGLR-----------------------------------------------LLLR 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 275 RVRIFTLGVVTVFFIFMVQFFSTVLmPFYLEDARGLTPGTAGTLLSLYPLMMVFFAPFGGWLADKWNVPAVALLGSIFIA 354
Cdd:cd17325 198 DRRLLALFLAIFVLAFAFGALEPFL-PLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSA 276
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 227189595 355 VGSLIGATLKSnapLTIYIISTLLVGIGSGLFQSPIGDVVMSVVPKNQLGIAGSFNALARNLGMVSG 421
Cdd:cd17325 277 VALLLLPLATS---FWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLG 340
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
22-481 |
6.93e-27 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 111.50 E-value: 6.93e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 22 PKRWWLLVALGFFAFMTNLDGSIVNIAVPIMAKDLKVPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIFKWGTGTF 101
Cdd:COG2271 6 RYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 102 VLGSLMAGINLGFNFLMLARMIQALGGAMTLANTYGIVTSTFALAERGRAMGVVSTFVALGGVAGPSLGGLILAHFSWPM 181
Cdd:COG2271 86 GLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 182 IFLINVPIGLIALGVSLWsmnngipqrgtydgwgmilqataiasgfwglnlaqqsgfddpvvlstlalavvaliafigfe 261
Cdd:COG2271 166 AFLILGLPGLLLALLRFW-------------------------------------------------------------- 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 262 qrqqapllplrifrvriftLGVVTVFFIFMVQFFSTVLMPFYLEDARGLTPGTAGTLLSLYPLMMVFFAPFGGWLADKWN 341
Cdd:COG2271 184 -------------------LLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLG 244
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 342 VP--AVALLGSIFIAVGSLIGATLksnAPLTIYIISTLLVGIGSGLFQSPIGDVVMSVVPKNQLGIAGSFNALARNLGmv 419
Cdd:COG2271 245 RRrkLVLAIGLLLAALALLLLALL---PSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLG-- 319
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 227189595 420 sgtAVATTVLFGTMSQLagsrvtnyptahpeffiSGLQVAMIVAAVLAILGAIAIGLTIKPW 481
Cdd:COG2271 320 ---GALGPLLVGYLLDA-----------------TGYQAAFLLLAALALLAALLALLLLRET 361
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
31-422 |
1.11e-24 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 104.81 E-value: 1.11e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 31 LGFFAFMTNLDGSIVNIAVP-IMAKDLKVPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIFKWGTGTFVLGSLMAG 109
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 110 INLGFNFLMLARMIQALGGAMTLANTYGIVTSTFALAERGRAMGVVSTFVALGGVAGPSLGGLILAHFSWPMIFLINVPI 189
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 190 GLIALgvslwsmnngipqrgtydgwgmilqataiasgfwglnlaqqsgfddpvVLSTLALAVVALIAFIGFEQRQQAPLL 269
Cdd:pfam07690 161 SLLAA------------------------------------------------VLLLLPRPPPESKRPKPAEEARLSLIV 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 270 PLRIFRVRIFTLGVVTVFFIFMVQFFSTVLMPFYLEDaRGLTPGTAGTLLSLYPLMMVFFAPFGGWLADKWNVPAVALLG 349
Cdd:pfam07690 193 AWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEV-LGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLA 271
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 227189595 350 SIFIAVGSLIGATLKSNAPLTIYIISTLLVGIGSGLFQSPIGDVVMSVVPKNQLGIAGSFNALARNLGMVSGT 422
Cdd:pfam07690 272 LLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
22-485 |
9.91e-24 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 102.65 E-value: 9.91e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 22 PKRWWLLVALGFFAFMTNLDGSIVNIAVPIMAKDLKVPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIFKWGTGTF 101
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 102 VLGSLMAGINLGFNFLMLARMIQALGGAMTLANTYGIVTSTFALAERGRAMGVVSTFVALGGVAGPSLGGLILAHFSWPM 181
Cdd:COG2223 81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 182 IFLInvpiglialgvslwsmnngipqrgtydgWGMILQATAIASGFWGLNLAQQSGFDDPVVLSTLalavvaliafigfe 261
Cdd:COG2223 161 AFLI----------------------------LGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQ-------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 262 qrqqapllpLRIFRVRIFTLGVVTVFFIFMVQFFSTVLMPFYLEDARGLTPGTAGTLLSLYPLMMVFFAPFGGWLADKWN 341
Cdd:COG2223 199 ---------LEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIG 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 342 VPAVALLGSIFIAVGSLIGATLksNAPLTIYIISTLLVGIGSGLFQSPIGDVVMSVVPKNQLGIAGSFNALARNLGmvsg 421
Cdd:COG2223 270 GRRVLLIVFALMALGLLLLALA--LGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLG---- 343
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 227189595 422 tAVATTVLFGTMSQLAGSRvtnyptahpeffisglQVAMIVAAVLAILGAIAIGLTIKPWQAHE 485
Cdd:COG2223 344 -GFLGPLLFGALLDATGSY----------------TAAFLVFAVLALVALVLTLLLYRRPRRAA 390
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
28-429 |
1.09e-22 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 99.16 E-value: 1.09e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 28 LVALGFFAFMTNLDGSIVNIAVPIMAKDLKVPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIFKWGTGTFVLGSLM 107
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 108 AGINLGFNFLMLARMIQALGGAMTLANTYGIVTSTFALAERGRAMGVVSTFVALGGVAGPSLGGLILAHFSWPMIFLINV 187
Cdd:cd17324 81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 188 PIGLIALGVSLWSMNNGIPQRGTydgwgmilqATAIASGFWGLnlaqqsgFDDPVVLSTLALAVVALIAFIGfeqrqqap 267
Cdd:cd17324 161 VLALLAALLLWRLLPSLPPKKPG---------SLGLLSSLLLL-------LRNPRLRLAYLITFLLFGGFFA-------- 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 268 llplrifrvriftlgvvtvffifmvqFFSTvlMPFYLEDARGLTPGTAGTLLSLYPLMMVFFAPFGGWLADKWNVPAVAL 347
Cdd:cd17324 217 --------------------------LYTY--LAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLI 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 348 LGSIFIAVGSLIGATLKSNAPLtiyIISTLLVGIGSGLFQSPIGDVVMSVVPKNQlGIAGSFNALARNLGMVSGTAVATT 427
Cdd:cd17324 269 ALLLLAAALLLLTLLGPSPLLL---LVGLVLWGLGFFAAHSALQTRVLRLAPEAR-GLASSLYLAAYNLGGALGAALGGL 344
|
..
gi 227189595 428 VL 429
Cdd:cd17324 345 VL 346
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
28-469 |
1.57e-22 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 98.80 E-value: 1.57e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 28 LVALGFFAFMTNLDGSIVNIAVPIMAKDLKVPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIFKWGTGTFVLGSLM 107
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 108 AGINLGFNFLMLARMIQALGGAMTLANTYGIVTSTFALAERGRAMGVVSTFVALGGVAGPSLGGLiLAHFSWPMIFLINV 187
Cdd:cd17474 81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGL-LAAISWRYPFFLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 188 PIGLIALGVSLWsmnngipqrgtydgwgmilqataiasgfwglnlaqqsgFDDPVVLSTLALAVVALIAFIgfeqrqqap 267
Cdd:cd17474 160 ALIPVAFLAILF--------------------------------------LLPEPKEKAKSSSATKLRDLK--------- 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 268 llplRIFRVRIFTLGVVTVFFIFMVQFFSTVLMPFYLEDARGLTPGTAGTLLSLYPLMMVFFAPFGGWLADKWNVPAVAL 347
Cdd:cd17474 193 ----KALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRIL 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 348 LGSIFIAVGSLIGATLKSNapLTIYIISTLLVGIGSGLFQSPIGDVVMSVVPKNQLGIAGSFNALARNLGMVSGtavatT 427
Cdd:cd17474 269 VIGLLLYALSLLLLGFVPS--LALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVG-----P 341
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 227189595 428 VLFGTMSQLAGSRVtnyptahpeFFISGLQVAMIVAAVLAIL 469
Cdd:cd17474 342 LLFGLLLEIFGLSA---------PFLVGAAIALAAAVLLALL 374
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
26-432 |
9.01e-21 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 93.79 E-value: 9.01e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 26 WLLVALGFFAFMTNldgSIVNIAVPIMAKDLKVPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIFKWGTGTFVLGS 105
Cdd:cd17320 2 LLLALLVALGPLAI---DMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILAS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 106 LMAGINLGFNFLMLARMIQALGGAMTLANTYGIVTSTFALAERGRAMGVVSTFVALGGVAGPSLGGLILAHFSWPMIFLI 185
Cdd:cd17320 79 LLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 186 NVPIGLIALGVSLWSMNNGIPQRGTYDGWGMILQATAiasgfwglnlaqqsgfddpvvlstlalavvaliafigfeqrqq 265
Cdd:cd17320 159 LALLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAYK------------------------------------------- 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 266 apllplRIFRVRIFTLGVVTVFFIFMVQFFSTVLMPFYLEDARGLTPGTAGTLLSLYPLMMVFFAPFGGWLADKWNVPAV 345
Cdd:cd17320 196 ------RVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRL 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 346 ALLGSIFIAVGS--LIGATLKSNAPLTIYIISTLLVGIGSGlFQSPIGDVVMSVVPKNQLGIAGSFNALARNLGMVSGTA 423
Cdd:cd17320 270 LRLGLLLLLAAAlvLLLAALLGGLSLWPLVAPLFLIFFGFG-LIFPNATSLALEPFPHVAGTASALLGFLQFLIGALAGA 348
|
....*....
gi 227189595 424 VATTVLFGT 432
Cdd:cd17320 349 LVGLLPNGT 357
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
27-428 |
3.74e-15 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 77.04 E-value: 3.74e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 27 LLVALGFFAFMTNLDGSIVNIAVPIMAKDLKVPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIFKWGTGTFVLGSL 106
Cdd:TIGR00710 6 FALLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 107 MAGINLGFNFLMLARMIQALGGAMTLANTYGIVTSTFALAERGRAMGVVSTFVALGGVAGPSLGGLILAHFSWPMIFLIN 186
Cdd:TIGR00710 86 GLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 187 VPIGLIALGVSLWSMNNGIPQRgtydgwgmilqaTAIASGFWGLNLaqqsgfddpvvlstlalavvaliafigfeqrqqa 266
Cdd:TIGR00710 166 SLAGILLSALIFFILPETLPYE------------ARIQISTYFETF---------------------------------- 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 267 pLLPLRIFRVRIFTLGVVTVFFIFMVQFFSTvlmPFYLEDARGLTPGTAGTLLSLYPLMMVFFAPFGGWLADKWNVPAVA 346
Cdd:TIGR00710 200 -LLLLKSKMFWGYALIYGASFGGFFAFFSGA---PFVYIDIMGVSPSVFGLLFALNIIAMIFGGFLNGRFIKKWGAKSLL 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 347 LLG-SIFIAVGSLIGATLKSNAPLTIYIISTL-LVGIGSGLFQSpigdVVMSVVPKNQLGIAGSFNALARNLGMVSGTAV 424
Cdd:TIGR00710 276 RMGlILFAVSAVLLEITAILGLGSWAMIIGPMmFVGIGNSMISS----IAMAYALEDFPHVAGTASALFGTLRLVLGAIV 351
|
....
gi 227189595 425 ATTV 428
Cdd:TIGR00710 352 GYLV 355
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
36-202 |
5.44e-15 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 76.15 E-value: 5.44e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 36 FMTNLDGSIVNIAVPIMAKDLKVPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIFKWGTGTFVLGSLMAGINLGFN 115
Cdd:cd17476 8 LLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFI 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 116 FLMLARMIQALGGAMTLANTYGIVTSTFAL-AERGRAMGVVSTFVALGGVAGPSLGGLILAHFSWPMIFLINVPIGLIAL 194
Cdd:cd17476 88 FFIICRALQGLGPAFLLPNAMALLGRTYPPgPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAILAAIVA 167
|
....*...
gi 227189595 195 GVSLWSMN 202
Cdd:cd17476 168 VAAIFWTS 175
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
31-429 |
5.45e-15 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 76.31 E-value: 5.45e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 31 LGFFAFMTNLDGSIVNIAVPIMAKDLKVPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIFKWGTGTFVLGSLMAGI 110
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 111 NLGFNFLMLARMIQALGGAMTLANTYGIVTSTFALAERGRAMGVVSTFVALGGVAGPSLGGLILAH--FSWPMIFLINVP 188
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 189 IGLIALGVSLWSMNngipqrgtydgwgmilqataiasgfwglnlaqqsgfddPVVLSTLALAVVALIAFIGfeqrqqapL 268
Cdd:cd06174 161 LALLAAILLLLVVP--------------------------------------DPPESARAKNEEASSKSVL--------K 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 269 LPLRIFRVRIFTLGVVTVFFIFMVQFFSTVLMPFYLEDARGLTPGTAGTLLSLYPLMMVFFAPFGGWLADKWNVPAVALL 348
Cdd:cd06174 195 LLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLL 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 349 GSIFIAVGSLIGATLksNAPLTIYIISTLLVGIGSGLFQSPIGDVVMSVVPKNQLGIAGSFNALARNLGMVSGTAVATTV 428
Cdd:cd06174 275 IGLLLMALGLALLLL--APSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFL 352
|
.
gi 227189595 429 L 429
Cdd:cd06174 353 L 353
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
30-442 |
6.36e-15 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 76.90 E-value: 6.36e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 30 ALGFFAFMTNLDGSIV--NIAVPIMAKDLkvPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIFKWGTGTFVLGSLM 107
Cdd:cd06179 1 AALCLAYFAQLFGVTLpaAVLPFIVADLG--PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 108 AGInlgfnflmlARMIQALGGAMTL--ANTYGIVTSTFALAE------RGRAMGVVSTFVALGGVAGPSLGGLIL--AHF 177
Cdd:cd06179 79 AGT---------AKSVNMLIGGQALigIGAGTQGLGAAVASElvpnkyRGLVQGVVNLVASPGSALGPLIAGALVeaNAA 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 178 SWPMIFLINVPIGLIALGVSLWSMNNGIPQRGTYDGW----------GMILQATAIASGFWGLNLAQQS-GFDDPVVLST 246
Cdd:cd06179 150 GWRWIFYINAIFNALALILLFFFYHPPPRPQLHGSSTrqklkrldwvGLFLLIAGLVLFLLGLSWGGNPyPWSSAHVIAP 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 247 LALAVVALIAFIGFE--QRQQAPLLPLRIFRVRIFTLGVVTVFFIFMVQFFSTVLMPFYLEDARGLTPGTAGTLLSLYPL 324
Cdd:cd06179 230 LVIGGVLLIAFGLYEwkGTKDGLLPPRLLFRGRNFALILIVAFVEGMIFYSLNIFWPQQISLLFTTDPLKAGLYQLPFGL 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 325 MMVFFAPFGGWLAD-----KWNVPAVALLGSIFIAVGSLIGATLKSNApltiyIISTLLVGIGSGLFQSPIGDVVMSVVP 399
Cdd:cd06179 310 GTLFGAILAGLLLTkikhiKWQLVAGFVLFTAFLALLALITPDNKALA-----IAFSVLAGIGIGGPLVLAIVIVQLSVP 384
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 227189595 400 KNQLGIAGSFNALARNLGMVSGTAVATTVLFGTMSQLAGSRVT 442
Cdd:cd06179 385 PEDIGTASGLLGSARALGGAVGTAIFTSILSNRLSKNLPARVA 427
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
28-476 |
3.78e-14 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 73.76 E-value: 3.78e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 28 LVALGFFAFMTNLDGSIVNIAVPIMAKD-LKVPASQMEWTVSLY--LIVLSALLlpFGKLGDRIGKQRIFKWGTGTFVLG 104
Cdd:cd17473 1 LITLLLASTLTVMAGAAIAPALPAIAQHfVPNSELLVPLLLTLPalFIALFAPL--AGWLADRFGRKRLLIAGLLLYGIG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 105 SLMAGINLGFNFLMLARMIQALGGAMTLANTYGIVTSTFALAERGRAMGVVSTFVALGGVAGPSLGGLiLAHFSWPMIFL 184
Cdd:cd17473 79 GVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGA-LAEIGWRAPFL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 185 INVpIGLIALGVSLWSMNNGIPQRGTYDGWGmilqataiasgfwglnlaqqsgfddpvvlstlalavvaliafigfeQRQ 264
Cdd:cd17473 158 VYL-LALPVLILVLLFLPEPARKSKSAASPG----------------------------------------------AAT 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 265 QAPLLPLRIFRVRIFTLGVVTVFFIFMVQffstvlMPFYLEDARGLTPGTAGTLLSLYPLMMVFFAPFGGWLADKWNVPA 344
Cdd:cd17473 191 AAALPWKRVLPIYFLAFLAMLLFYVIPIQ------LPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRR 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 345 VALLGSIFIAVGSLIGATLKSNAPLtiyIISTLLVGIGSGLFQSPIGDVVMSVVPKNQLGIAGSFNALARNLGMvsgtaV 424
Cdd:cd17473 265 LLAIGFALMALGFLLLALASGLWVV---LLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQ-----F 336
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 227189595 425 ATTVLFGTMSQLAGsrvtnyptahpeffisGLQVAMIVAAVLAILGAIAIGL 476
Cdd:cd17473 337 LSPLVLGPLVNLTG----------------GLSGAFLILGVLALVLAIVLLL 372
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
33-425 |
2.68e-13 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 71.09 E-value: 2.68e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 33 FFAFMTNldgSIVNIAVPIMAKDLKVPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIFKWGTGTFVLGSLMAGINL 112
Cdd:cd17489 6 FFFFLSF---YLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 113 GFNFLMLARMIQALGGAMTLANTYGIVTSTFALAERGRAMGVVSTFVALGGVAGPSLGGLILAHFSWPMIFLINVPIGLI 192
Cdd:cd17489 83 SVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 193 ALGVSLwsmnnGIPQRGTYDGwgmilqataiasgfwglnlaqqsgfddpvvlstlalavvaliafigfEQRQQAPLLPLR 272
Cdd:cd17489 163 ALLLVF-----LVKDPPPVAA-----------------------------------------------EEAEAGTRAFRR 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 273 IFRVRIFTLGVVTVFFIFMVQFFSTVLMPFYleDARGLTpgTAGTLLSLYPLMMVFFAPFGGWLADKWNVPAVALLGSIF 352
Cdd:cd17489 191 LVEKKVLPPALILFLASIAYGAISTFLPLYA--AERGIS--NAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLL 266
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 227189595 353 IAVGSLIgatLKSNAPLTIYIISTLLVGIGSGLFQSPIGDVVMSVVPKNQLGIAGSFNALARNLGMVSGTAVA 425
Cdd:cd17489 267 LALGLLL---LSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLL 336
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
25-474 |
2.04e-12 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 68.37 E-value: 2.04e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 25 WWLLVALGFFAFMTN-LDGSIVNIAVPIMAKDLKVPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIFKWGTGTFVL 103
Cdd:cd17319 1 RWRIIPLLFLAYVINyLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 104 GSLMAGINLGFNFLMLARMIQALGGAMTLANTYGIVTSTFALAERGRAMGVVSTFVALGGVAGPSLGGLILAHFSWPMIF 183
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 184 LINVPIGLIALGVSLWSmnngIPQrgtydGWGMILQATAIASGFWGLNLaqqsgfddpvvlstlalavvaliafigfeqr 263
Cdd:cd17319 161 IIEGLLGLLLAVLWWFY----LRQ-----VWGLALGYFGINYALYGLLT------------------------------- 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 264 qqapllplrifrvriftlgvvtvffifmvqffstvLMPFYLEDARGLTPGTAGTLLSLYPLMMVFFAPFGGWLADKWNVP 343
Cdd:cd17319 201 -----------------------------------WLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRG 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 344 AVALLGSIFIAVGSLIGATLKSNAPLTIYIISTLLVGIGSGLFQSPIGDVVMSVVPKNQLGIAGSFNALARNLGmvsgtA 423
Cdd:cd17319 246 ARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLG-----G 320
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 227189595 424 VATTVLFGTMSQLAGSrvtnyptahpeffisgLQVAMIVAAVLAILGAIAI 474
Cdd:cd17319 321 FVAPLLIGYLVDATGS----------------YTAAFLFLAAVALLAALLV 355
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
20-386 |
2.14e-11 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 65.26 E-value: 2.14e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 20 TAPKRWWLLVALGFFAFMTNLDGSIVNIAVPIMAKDLKVPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIFKWGTG 99
Cdd:COG0738 2 SKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 100 TFVLGSLMAGINLGFNFLMLARMIQALGGAM--TLANTYGIVTSTfalAERGRAMGVVSTFVALGGVAGPSLGGLILAH- 176
Cdd:COG0738 82 LMALGLLLFALAPSYPLLLLALFLLGLGLGLldVAANPYVAALGP---ETAASRLNLLHAFFSLGALLGPLLGGLLILLg 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 177 --FSWPMIFLInvpIGLIALGVSLWSMNNGIPQRGTYDgwgmilqataiasgfwglnlaqqsgfddpvvlstlalavval 254
Cdd:COG0738 159 lsLSWHLPYLI---LAVLLLLLALLFLRSKLPEIEEEE------------------------------------------ 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 255 iafigfEQRQQAPLLPLRIFRVRIFTLGVVTVFFIFMVQFFSTVLMPFYLEDARGLTPGTAGTLLSLYPLMMVFFAPFGG 334
Cdd:COG0738 194 ------EEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGG 267
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 227189595 335 WLADKWNVPAVALLGSIFIAVGSLIGATLKSnapLTIYIISTLLVGIGSGLF 386
Cdd:COG0738 268 FLLKRFGPVRLLRLSALLAAVGLLLALLAPG---PWLALIGLALVGLGLSLM 316
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
14-358 |
2.87e-11 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 65.07 E-value: 2.87e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 14 NMQRSETAPKRWWLLVALGFFA-FMTNLDGSIVNIAVPIMAKDLKVPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQR 92
Cdd:TIGR00895 4 NNIRKQPLSRYQWRAIILSFLImLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 93 IFKWGTGTFVLGSLMAGINLGFNFLMLARMIQALGGAMTLANTYGIVTSTFALAERGRAMGVVSTFVALGGVAGPSLGGL 172
Cdd:TIGR00895 84 VLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 173 ILAHFSWPMIFLInvpiGLIALGVSLWSMNNGIPQRGTYdgwgMILQATAiasgfwglNLAQQSGFDDPVVLSTLALAVV 252
Cdd:TIGR00895 164 LIPVFGWRSLFYV----GGIAPLLLLLLLMRFLPESIDF----LVSKRPE--------TVRRIVNAIAPQMQAEAQSALP 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 253 ALIAFIGFEQRQQAPLLPLRifRVRIFTLGVVTVFFIFMVQFFSTVLMPFYLEDArGLTPGTAGTLLSLYPLMMVFFAPF 332
Cdd:TIGR00895 228 EQKSTQGTKRSVFKALFQGK--TARITVLLWLLYFMLLVGVYFLTNWLPKLMVEL-GFSLSLAATGGALFNFGGVIGSII 304
|
330 340
....*....|....*....|....*....
gi 227189595 333 GGWLADKWNVPAVA---LLGSIFIAVGSL 358
Cdd:TIGR00895 305 FGWLADRLGPRVTAlllLLGAVFAVLVGS 333
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
47-198 |
1.34e-10 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 63.12 E-value: 1.34e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 47 IAVPIMAKDLKVPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIFKWGTGTFVLGSLMAGINLGFNFLMLARMIQAL 126
Cdd:PRK10473 24 VGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGI 103
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 227189595 127 GGAMTLANTYGIVTSTFALAERGRAMGVVSTFVALGGVAGPSLGGLILAHFSWPMIFLINVPIGLIALGVSL 198
Cdd:PRK10473 104 GAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTMAAMGILVLLLSL 175
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
24-199 |
1.35e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 62.98 E-value: 1.35e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 24 RWWLLVALGFFAFMTNLDGSIVNIAVPIMAKDL-KVPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIFKWGTGTFV 102
Cdd:cd17325 197 RDRRLLALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSA 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 103 LGSLMAGINLGFNFLMLARMIQALGGAMTLANTYGIVTSTFALAERGRAMGVVSTFVALGGVAGPSLGGLILAHFSWPMI 182
Cdd:cd17325 277 VALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATP 356
|
170
....*....|....*..
gi 227189595 183 FLINVPIGLIALGVSLW 199
Cdd:cd17325 357 FLAAAALLLLAAVLFLL 373
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
31-198 |
1.47e-10 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 62.59 E-value: 1.47e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 31 LGFFAFMTNLDGSIVNIAVPIMAKDLKVPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIFKWGTGTFVLGSLMAGI 110
Cdd:cd17323 4 ISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCAL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 111 NLGFNFLMLARMIQALGGAMTLANTYGIVTSTFALAERGRAMGVVSTFVALGGVAGPSLGGLILAHFSWPMIFLINVPIG 190
Cdd:cd17323 84 APNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIIS 163
|
....*...
gi 227189595 191 LIALGVSL 198
Cdd:cd17323 164 GFCLILIF 171
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
16-384 |
1.65e-10 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 62.58 E-value: 1.65e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 16 QRSETAPKRWWLLVALGFFAFmtNLDGSIVNIA--VPIMAKDLKVPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRI 93
Cdd:COG2807 8 ARRSRRAGRWLLLLAIVLVAL--NLRPAITSVGplLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERT 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 94 FKWGTGTFVLGSLMAGINLGFNFLMLARMIQALGGAMTLANTYGIVTSTFAlAERGRAMGVVSTFVALGGVAGPSLGGLI 173
Cdd:COG2807 86 LLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVPL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 174 LAHFSWPMiflinvpiglialgvslwsmnngipqrgtydgwgmilqataiASGFWGLnlaqqsgfddpVVLSTLALAVVA 253
Cdd:COG2807 165 AAALGWRG------------------------------------------ALAVWAL-----------LALLALLLWLPL 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 254 LIAFIGFEQRQQAPLLPLRIFRVRIFtLGVVTVFFIFMVQFFSTV-LMPFYLEDaRGLTPGTAGTLLSLYPLMMVFFAPF 332
Cdd:COG2807 192 LRRRPAAAAAAPAAASLRSLWRSPLA-WLLTLFFGLQSLLYYAVVaWLPPILRD-AGLSAATAGLLLSLFQLAGIPGSLL 269
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 227189595 333 GGWLADKWNVPAVALLGSIFIAVGSLIGATLksnAPLTIYIISTLLVGIGSG 384
Cdd:COG2807 270 VPLLADRLGDRRPLLLLLGLLGLAGLLGLLL---APGSLPWLWAVLLGLGQG 318
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
80-202 |
1.41e-09 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 56.50 E-value: 1.41e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 80 PFGKLGDRIGKQRIFKWGTGTFVLGSLMAGINLGFNFLMLARMIQALGGAMTLANTYGIVTSTFALAERGRAMGVVSTFV 159
Cdd:TIGR00880 17 LSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGVALGLMSAGI 96
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 227189595 160 ALGGVAGPSLGGLILAHFSWPMIFLINVPIGLIALGVSLWSMN 202
Cdd:TIGR00880 97 ALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
207-474 |
2.06e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 59.53 E-value: 2.06e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 207 QRGTYDGWGMILQATAIASGFWG-------LNLAQQSGFDDPVVLSTLALAVVALIAFIGFEQR--QQAPLLPLR----- 272
Cdd:COG2211 144 ERTRLSSWRFAFAGLGGLLASVLppplvaaFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERpvPEEEKVSLKeslka 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 273 IFRVRIFTLGVVTVFFIFMVQFFSTVLMPFYLEDARGLTPGTAGTLLSLYPLMMVFFAPFGGWLADKWNVPAVALLGSIF 352
Cdd:COG2211 224 LLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLL 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 353 IAVGSLIGATLKSNAPLTIYIIsTLLVGIGSGLFQSPIGDVVMSVVPKNQL-------GIAGSFNALARNLGMVSGTAVA 425
Cdd:COG2211 304 AALGLLLLFFLGPGNLWLLLVL-AALAGIGLGAILVLPWAMLADVVDYDEWktgrrreGLYFGIFTFAIKLGQALAGALA 382
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 227189595 426 TTVLfgtmsQLAGsrvTNYPTAHPEFFISGLQVAMIVAAVLAILGAIAI 474
Cdd:COG2211 383 GLLL-----ALFG---YVAGAAQSPSALTGIRLLFFLLPAVLLLLAALL 423
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
29-194 |
2.74e-09 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 58.75 E-value: 2.74e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 29 VALGFFAFMTN-LDGSIVNIAVPIMAKDLKVPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIFKWGTGTFVLGSLM 107
Cdd:cd17365 1 LALCFLIIVLDgFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 108 AGINLGFNFLMLARMIQALGGAMTLANTYGIVTSTFALAERGRAMGVVSTFVALGGVAGPSLGGLILAHFSWPMIFLINV 187
Cdd:cd17365 81 TAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGG 160
|
....*..
gi 227189595 188 PIGLIAL 194
Cdd:cd17365 161 VPPLILL 167
|
|
| MFS_ARN_like |
cd17322 |
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ... |
72-425 |
6.58e-09 |
|
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340880 [Multi-domain] Cd Length: 514 Bit Score: 58.09 E-value: 6.58e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 72 IVLSALLLPFGKLGDRIGKQRIFKWGTGTFVLGSLMAGINLGFNFLMLARMIQALGGA-MTLANTYgIVTSTFALAERGR 150
Cdd:cd17322 48 IVSAVSQPPYAKLSDVFGRLELFLVSLLLYVVGTIIMAASTNVQTYAAGSVFYNAGYTgLNLLLTL-ILADFSSLKNRGF 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 151 AMGVVSTFVALGGVAGPSLGGLILAHFSWPM---IFLINVPIGLIALGVSLWSMNN---------GIPQRGTY------- 211
Cdd:cd17322 127 ASAIPSLPYIITTWIGGNIAQAALPNSNWRWgygMWAIILPLSSLPLVLCLLYMQRkarkdgeikELKNQETEeqtggls 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 212 ----------DGWGMILQATAIASGFWGLNLAQQ--SGFDDPVVLSTLALAVVALIAFIGFEQR-QQAPLLPLRIFRVRI 278
Cdd:cd17322 207 qnlvklfwklDIFGVILLTAGLGLILVPLTLAGGakSKWKNSSIIAMIVLGGVLLVAFLLWEAKfAKYPFLPFRLLKDRT 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 279 FTLGVVTVFFIFMVQFFSTVLMPFYLEDARGLTPGTAGTLLSLYPLMMVFFAPFGGWLADKWNVPAVALLGSI---FIAV 355
Cdd:cd17322 287 ILAACLIDFFYFFSYYIFSDYLYTVLQVAVGESITSATRITNLYSFVSTVAGIFVGFLIRKTRRYKVLVIIGVplyIVGM 366
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 356 GSLIGATLKSNAPLTIyIISTLLVGIGSGLFQSPIGDVVMSVVPKNQLGIAGSFNALARNLGMVSGTAVA 425
Cdd:cd17322 367 GLLIRYRGGSGSHGGI-IGALILIGIGGGLFTYPVQVSVQASVSHQEMAVVTALLLTVYSIGGAVGAAIS 435
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
283-429 |
2.31e-08 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 56.08 E-value: 2.31e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 283 VVTVFFIFMVQFFSTVLMPFYLEDARGLTPGTAGTLLSLYPLMMVFFAPFGGWLADKWNVPAVALLGsIFIAVGSLIGAT 362
Cdd:cd17329 5 LIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAG-LLLRALGFALLG 83
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 227189595 363 LKSNAPLtiYIISTLLVGIGSGLFQSPIGDVVMSVVPKNQLGIAGSFNALARNLGMVSGTAVATTVL 429
Cdd:cd17329 84 FAHSPWL--FAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLL 148
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
79-333 |
3.33e-08 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 55.86 E-value: 3.33e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 79 LPFGKLGDRIGKQRIFKWGTGTFVLGSLMAGINLGFNFLMLARMIQALGGAMTLANTYGIVTSTFALAERGRAMGVVSTF 158
Cdd:PRK03893 73 LLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISG 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 159 VALGGVAGPSLGGLILAHFSWPMIFLinvpIGLIALGVSLWsMNNGIPQ----------------------RGTYDGWGM 216
Cdd:PRK03893 153 FSIGAVVAAQVYSLVVPVWGWRALFF----IGILPIIFALW-LRKNLPEaedwkekhagkapvrtmvdilyRGEHRIINI 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 217 ILQATAIASGFWGLNLAQQSGfddpvvLSTLALAVVALIAFIGFEQRQQAPLLPlrifrvrIFTLGVVTVFFIFMVQFFS 296
Cdd:PRK03893 228 LLTLAAAAALWFCFAGNLQNA------AIVAVLGLLCAAIFISFMVQSSGKRWP-------TGVMLMVVVLFAFLYSWPI 294
|
250 260 270
....*....|....*....|....*....|....*..
gi 227189595 297 TVLMPFYLEDARGLTPGTAGTLLslyplmmvFFAPFG 333
Cdd:PRK03893 295 QALLPTYLKTDLGYDPHTVANVL--------FFSGFG 323
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
28-384 |
5.30e-08 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 54.53 E-value: 5.30e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 28 LVALGFFAFMTNLDGSIVNIAVPIMAKDLK--VPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIFKWGTGTFVLGS 105
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSlgLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 106 LMAGINLGFNFLMLARMIQ--ALGGAMTLANTYgiVTSTFALAERGRAMGVVSTFVALGGVAGPSLGGLILAHFSwpmif 183
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQgiGIGGEYPGASTY--VAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLS----- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 184 linvpiglialgvslwsmnngipqrgTYDGWgmilqataiasgfwglnlaqqsgfddpvvlsTLALAVVALIAFIGFEQR 263
Cdd:cd17316 154 --------------------------GDWGW-------------------------------RILFLIGALPALLALLLR 176
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 264 qqapllplrifrvRIFTLGVVTVFFIFMVQFFSTVLMPFYLEDARGLTPGTAGTLLSLYPLMMVFFAPFGGWLADKWNVP 343
Cdd:cd17316 177 -------------RRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRK 243
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 227189595 344 AVALLGSIFIAVGSLIGATLKSNAPLTIYIISTLLVGIGSG 384
Cdd:cd17316 244 KTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGG 284
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
29-194 |
7.11e-08 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 54.48 E-value: 7.11e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 29 VALGFFA-FMTNLDGSIVNIAVPIMAKDLKvpasqmeWTVSLYLIVLSALL-------LPFGKLGDRIGKQRI-----FK 95
Cdd:cd17380 1 VILLFLAtCICYADRVNMPIAIVPMAKEFG-------WSKTDQGLVLSSFFwgyaltqVLGGYLADRFGGKKVlllavAL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 96 WGTGTFVLGSLmagINLGFNFLMLARMIQALGGAMTLANTYGIVTSTFALAERGRAMGVVSTFVALGGVAGPSLGGLILA 175
Cdd:cd17380 74 WSLATLLTPLL---AYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLE 150
|
170
....*....|....*....
gi 227189595 176 HFSWPMIFLInvpIGLIAL 194
Cdd:cd17380 151 YYGWPSVFYF---FGLLGL 166
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
22-196 |
9.02e-08 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 54.09 E-value: 9.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 22 PKRWWLLVALGFFAFmtnldgSIVNIAVPIM-AKDLKVPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIFKWGTGT 100
Cdd:cd17370 200 KAFWLYLLAVALFAL------GNFSFAFLILrAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLS 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 101 FVLGSLMAGINLGFNFLMLARMIQALGGAMTLANTYGIVTSTFALAERGRAMGVVSTFVALGGVAGPSLGGLILAHFSWP 180
Cdd:cd17370 274 LALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPS 353
|
170
....*....|....*.
gi 227189595 181 MIFLINVPIGLIALGV 196
Cdd:cd17370 354 AAFLFSAVLALIALLL 369
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
274-429 |
9.69e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 53.82 E-value: 9.69e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 274 FRVRIFTLGVVTVFFIFMVQFFSTVLMPFYLEDaRGLTPGTAGTLLSLYPLMMVFFAPFGGWLADKWNVPAVALLGSIFI 353
Cdd:COG2814 7 RRWLALLALALGAFLSGLGIGIVLPALPLIAAD-LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 227189595 354 AVGSLIGATLKSnapLTIYIISTLLVGIGSGLFQSPIGDVVMSVVPKNQLGIAGSFNALARNLGMVSGTAVATTVL 429
Cdd:COG2814 86 ALGSLLCALAPS---LWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLA 158
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
14-194 |
2.87e-07 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 52.66 E-value: 2.87e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 14 NMQRSETAPKRWWLLVALGF-FAFMTNLDGSIVNIAVPIMAKDLKVPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQR 92
Cdd:PRK11551 2 STRTSSASSSRLALTIGLCFlVALLEGLDLQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 93 IFKWGTGTFVLGSLMAGINLGFNFLMLARMIQALGGAMTLANTYGIVTSTFALAERGRAMGVVSTFVALGGVAGPSLGGL 172
Cdd:PRK11551 82 ILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVL 161
|
170 180
....*....|....*....|....
gi 227189595 173 ILAHFSWPMIFLIN--VPIGLIAL 194
Cdd:PRK11551 162 AAGDAAWRHIFYVGgvGPLLLVPL 185
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
48-199 |
3.09e-07 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 52.22 E-value: 3.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 48 AVPIMAKDLKVPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIFKWGTGTFVLGSLMAGINLGFNFLMLARMIQALG 127
Cdd:PRK11102 13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 227189595 128 GAMTLANTYGIVTSTFALAERGRAMGVVSTFVALGGVAGPSLGGLILAHFSWPMIFLINVPIGLIALGVSLW 199
Cdd:PRK11102 93 AAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFF 164
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
37-192 |
4.24e-07 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 51.85 E-value: 4.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 37 MTNLDGSIVNIAVPIMAKDLKVPASQMEWTVSLYLIVLSAL-------LLPFGKLGDRIGKQRIFKWGTGTFVLGSLM-- 107
Cdd:cd17318 25 MVNSTATHDNNNTSTDKDTLPVEAPEFDWSEKTQGIILSSFfygyiltQIPGGYLAEKYGAKRVLGYSILITALLTLLtp 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 108 AGINLGFNFLMLARMIQALGGAMTLANTYGIVTSTFALAERGRAMGVVSTFVALGGVAGPSLGGLILAHFSWPMIFLINV 187
Cdd:cd17318 105 LAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFG 184
|
....*
gi 227189595 188 PIGLI 192
Cdd:cd17318 185 GLGLL 189
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
46-428 |
6.35e-07 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 51.61 E-value: 6.35e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 46 NIAVPIMAKDLKVPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIFKWGTGTFVLGSLMAGINLGFNFLMLARMIQA 125
Cdd:TIGR00881 15 ALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNG 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 126 LGGAMTLANTYGIVTSTFALAERGRAMGVVSTFVALGGVAGPSLGGLILA-HFSWPMIFLINVPIGLIALGVSLWSMNNG 204
Cdd:TIGR00881 95 IFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAeLYSWHWVFIVPGIIAIIVSLICFLLLRDS 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 205 IPQRGTYDGWGMILQATAIASGFWGLNLAQQSGFDDPVVLSTlalaVVALIAFIGFeqrqqapllplrifrvriftlgvv 284
Cdd:TIGR00881 175 PQSCGLPPAEEMPNEEPDGDAEKKEEELTKKQIFLQYVLLNK----VLWYISLGYV------------------------ 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 285 tvfFIFMVQFFSTVLMPFYLEDARGLTPGTAGTLLSLYPLMMVFFAPFGGWLADKWNVPAVALLGSIFIA--VGSLIGAT 362
Cdd:TIGR00881 227 ---FVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLAVFFMAliIVSLLVYW 303
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 227189595 363 LKSNAPLTIYIISTLLVGIGSGLFQSPIGDVVMSVVPKNQLGIAGSFNALARNLG-MVSGTAVATTV 428
Cdd:TIGR00881 304 LNPAANPLMDLICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGgILAGLPLGYLA 370
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
36-425 |
9.01e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 51.08 E-value: 9.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 36 FMTNLDGSIVNIAVPIMAKDLKVPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIFKWGTGTFVLGSLMAGINLGFN 115
Cdd:cd06173 9 LLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 116 -----FLMLARMIQALGGAMTLANTYGIVTSTFALAERGRAMGVVSTFVALGGVAGPSLGGLILAHFSWPMIFLINVpig 190
Cdd:cd06173 89 slslwLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINA--- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 191 lialgvslwsmnngipqrgtydgwgmilqATAIASGfwglnlaqqsgfddpVVLSTLALAVVALIAFIGFEQRQQAPLLP 270
Cdd:cd06173 166 -----------------------------LSFLLSA---------------LLLLFIRRPPPAAPGESSSLLLRDLREGL 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 271 LRIFRVRIFTLGVVTVFFIFMVQFFSTVLMPFYLEDARGLTPGTAGTLLSLYPLMMVFFAPFGGWLADKWNVPAVALLGS 350
Cdd:cd06173 202 RYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGA 281
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 227189595 351 IFIAVGSLIGATLksnAPLTIYIISTLLVGIGSGLFQSPIGDVVMSVVPKNQLGIAGSFNALARNLGMVSGTAVA 425
Cdd:cd06173 282 LLLGLALLVLGLS---PSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLA 353
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
49-198 |
1.02e-06 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 50.68 E-value: 1.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 49 VPIMAKDLKVPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIF-KWGTGTFVLGSLMAGINLGFNFLMLARMIQALG 127
Cdd:cd17490 19 LSPYAESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFiIIGLLFTVLASLIMILFPSPWGLLIARFLSGIA 98
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 227189595 128 GAMTLANTYgIVTSTFALAERGRAMGVVSTFVALGGVAGPSLGGLILAHFSWPMIFLINVPIGLIALGVSL 198
Cdd:cd17490 99 AATWVSFTV-LYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSL 168
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
36-474 |
2.12e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 49.86 E-value: 2.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 36 FMTNLDGSIVNIAVPIMAKDLKVPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIFKWGTGTFVLGSLMAGINLGFN 115
Cdd:cd17478 6 FLNDFYQGFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 116 FLMLARMIQALGGAMTLANTYGIVTSTFAlAERGRAMGVVSTFVALGGVAGPSLGGLILAHFSWPMIFLINVPIGLIALG 195
Cdd:cd17478 86 LLLLLVALAGIGSAAFHPEGARLASQAAG-GRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVAL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 196 vslwsmnngipqrgtydgwgmilqataiasgfwglnlaqqsgfddpvvlstLALAVVALIAFIGFEQRQQAPLLPLRIFR 275
Cdd:cd17478 165 ---------------------------------------------------LLLRLRPLKKPEAKKAAAKSSARSTLKGV 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 276 VRIFTLGVVTVFFIFMVQFFSTVLMPFYLEDaRGLTPGTAGTLLSLYPLMMVFFAPFGGWLADKWNVPAVaLLGSIFIAV 355
Cdd:cd17478 194 WRALLLLLIIVFLRSWVLSSLTTFLPFYLVQ-RGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRV-IIASLLLAA 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 356 GSLIGATLksnAPLTIYIISTLLVGIGSGLFQSPIGDVVMSVVPKNqLGIAGSFnalarNLGMVSGTAVATTVLFGTMSQ 435
Cdd:cd17478 272 PFLLLFLL---TPGIWSYILLVLAGFLLFASFPVTVVLAQELLPGN-VGLASGL-----MMGLSFGLGGIGAPVLGALAD 342
|
410 420 430
....*....|....*....|....*....|....*....
gi 227189595 436 lagsrvtnyptahpeffISGLQVAMIVAAVLAILGAIAI 474
Cdd:cd17478 343 -----------------AFGLESVLLILALLPLLGALLA 364
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
207-429 |
2.41e-06 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 49.48 E-value: 2.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 207 QRGTYDGWGMILQATAIASGFWGLNLAQQSGFDDPVVLSTLALAVVALIAFIGFEQRQQAPLLPLRIFRV-RIFTLGVVT 285
Cdd:cd17477 117 NRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPFLIAAVLLLLALVPLLLTRRAAPEIEEAESISLRRLlRIAPLALLG 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 286 VFFIFMVQFFSTVLMPFYLEDArGLTPGTAGTLLSLYPLMMVFFAPFGGWLADKWNVPAVaLLGSIFIAVGSLIGATLKS 365
Cdd:cd17477 197 AFVAGFLEGAFYSLLPLYGLRL-GLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRV-LLGCALLGALAALLLPLVP 274
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 227189595 366 NAPLTIYIISTLLVGIGSGLFqsPIGDVVM-SVVPKNQLGIAGSFNALARNLGMVSGTAVATTVL 429
Cdd:cd17477 275 GLPLALLVLLFLWGGAAGPLY--TLALALAgDRLPGDELVAANAALLLLYGLGSVIGPLLAGALM 337
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
50-439 |
2.88e-06 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 49.54 E-value: 2.88e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 50 PIMAKDLKVPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIFkwGTGTFVLGSLMAGINLGFNFLMLAR---MIQAL 126
Cdd:cd17475 20 PFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVL--AVGLLLMGAAALLMALVGSYPVLLVllfLVGAG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 127 GGAMTLANTYGIVTStFALAERGRAMGVVSTFVALGGVAGPSLGGLILAHFSWPMIFLINvpiglialgvslwsmnngip 206
Cdd:cd17475 98 YGSVQPGGGRAIMRW-FPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVA-------------------- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 207 qrgtydgwGMILQATAIASGFWglnlaqqsgFDDPVVLSTLALAVVALIAFIGfeqrqqapllplRIFRVRIFTLGVVTV 286
Cdd:cd17475 157 --------GLVSILAAVLFWLF---------YREPPAASAATESASTLLRSLK------------EVLRNRDVWLIAIAG 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 287 FFIFMVQFFSTVLMPFYLEDARGLTPGTAGTLLSLYPLMMVFFAPFGGWLADKW---NVPAVALLGSIFIAVGSLIGATL 363
Cdd:cd17475 208 ALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVfggRRRPVLVITAAIAAAALLVLSLL 287
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 227189595 364 KSNAPLTIYIISTLLVGIGSGLFQSPIGDVVMSVVPKNQLGIAGSFnalarNLGMVSGTAVATTVLFGTMSQLAGS 439
Cdd:cd17475 288 SPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGL-----ANTINFIGIAIGPPLFGLLVDATHS 358
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
284-425 |
3.41e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 48.95 E-value: 3.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 284 VTVFFIFMVQFFSTVLMPFYLEDARGLTPGTAGTLLSLYPLMMVFFAPFGGWLADKWNVPAVALLGSIFIAVGSLIGAtl 363
Cdd:pfam07690 3 LAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL-- 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 227189595 364 kSNAPLTIYIISTLLVGIGSGLFQSPIGDVVMSVVPKNQLGIAGSFNALARNLGMVSGTAVA 425
Cdd:pfam07690 81 -FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLG 141
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
48-184 |
4.14e-06 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 48.75 E-value: 4.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 48 AVPIMAKDLKVPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIFKWGTGTFVLGSLMAGINLGFNFLMLARMIQALG 127
Cdd:PRK11652 30 AIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLG 109
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 227189595 128 GAMTLANTYGIVTSTFALAERGRAMGVVSTFVALGGVAGPSLGGLILAHFSWPMIFL 184
Cdd:PRK11652 110 TGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYL 166
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
48-199 |
8.20e-06 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 47.96 E-value: 8.20e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 48 AVPIMAKDLKVPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIFKWGTGTFVLGSL-MAGINLGFNFLMLaRMIQAL 126
Cdd:PRK11043 28 AFKAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLgMLWVESAAQLLVL-RFVQAV 106
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 227189595 127 GGAMTLANTYGIVTSTFalaERGRAMGVVST---FVALGGVAGPSLGGLILAHFSWPMIFLINVPIGLIALGVSLW 199
Cdd:PRK11043 107 GVCSAAVIWQALVIDRY---PAQKANRVFATimpLVALSPALAPLLGAWLLNHFGWQAIFATLFAITLLLILPTLR 179
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
76-199 |
9.30e-06 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 47.57 E-value: 9.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 76 ALLLPFGKLGDRIGKQRIFKWGTGTFVLGSLMAGINLGFNFLMLARMIQALGGAMTLANTYGIVTSTFALAERGRAMGVV 155
Cdd:cd17330 226 AQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGII 305
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 227189595 156 STFVALGGVAGPSLGGLILAHFSWPMIFLINVPIGLIALGVSLW 199
Cdd:cd17330 306 QSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
29-201 |
1.18e-05 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 47.51 E-value: 1.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 29 VALGFFAFMTNLDGSIVNIAVPIMAKDLKVPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIFKWGTGTFVLGSLMA 108
Cdd:PRK15403 19 MALILYDFAAYLTTDLIQPGIINVVRDFNADVSLAPASVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAAT 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 109 GINLGFNFLMLARMIQalGGAMTLANTYGIVTSTFALAERG--RAMGVVSTFVALGGVAGPSLGGLILAHFSWPMIFLIN 186
Cdd:PRK15403 99 LFTTSMTQFLIARFIQ--GTSICFIATVGYVTVQEAFGQTKgiKLMAIITSIVLVAPIIGPLSGAALMHFVHWKVLFAII 176
|
170
....*....|....*
gi 227189595 187 VPIGLIALGVSLWSM 201
Cdd:PRK15403 177 AVMGLIAFVGLLLAM 191
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
24-179 |
1.28e-05 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 47.66 E-value: 1.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 24 RWWLLVALGFFAFMTNLDGSIVNIAVPIMAKDLKVPASQMEWTVSL-YLIVLSALLLpFGKLGDRIGKQRIFKWGTGTFV 102
Cdd:TIGR01299 165 QWALFFVLGLALMADGVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIvYLGMMVGAFF-WGGLADKLGRKQCLLICLSVNG 243
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 227189595 103 LGSLMAGINLGFNFLMLARMIQALGGAMTLANTYGIVTSTFALAERGRAMGVVSTFVALGGVAGPSLGGLILAHFSW 179
Cdd:TIGR01299 244 FFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIGGIYAAAMAWAIIPHYGW 320
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
71-399 |
1.48e-05 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 47.23 E-value: 1.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 71 LIVLSALLLPFGKLGDRIGKQRIFKWGTGTFVLGSLMAGINLGFNFLMLARMIQALGGAMTLANTYGIVTSTFALAERGR 150
Cdd:cd17328 44 IISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTR 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 151 AMGVVSTFVALGGVAGPSLGGLILAHF-SWPMIFLINVPIGLIALGVSLWSMnnGIPQRGTYDGWGM-ILQATAIASGFW 228
Cdd:cd17328 124 ALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVLGVLLAILLLLFV--REPPRGAAEGGVMaKSTATSFLADLK 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 229 glNLAQQSGFddpvVLSTLAlavVALIAFIGFEQRQQAPLLPLRIFRVRIFTLGVVTVFFifmvqffstvlmpfyledar 308
Cdd:cd17328 202 --ALAKNPSF----ILSTLG---FTAVSFVTGALAFWAPTFFLRAFGVGDLSSADVGLIF-------------------- 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 309 GLTPGTAGtllslyplmmVFFAPFGGWLADKWN---------VPAVALLGSIFIAVGSLIGATLKSNAP-LTIYIISTLL 378
Cdd:cd17328 253 GAITCIAG----------VLGVLLGGILADRLRrktpradplVCAVGLLAAAPFLFLALVLALSNLLLAwVLLFLGEFLL 322
|
330 340
....*....|....*....|.
gi 227189595 379 vgigsGLFQSPIGDVVMSVVP 399
Cdd:cd17328 323 -----SLNWAPVFAILLYVVI 338
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
46-469 |
1.66e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 46.88 E-value: 1.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 46 NIAVPIMAKDLKVPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIFKWGTGTFVLGSLMAGINLGFNFLMLARMIQA 125
Cdd:cd17312 23 SVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 126 LGGAMTLANTYGIVTSTFALAERGRAMGVVSTFVALGGVAGPSLGGLILAHFSWPMIFLINvPIGLIALGVSLWsmnngi 205
Cdd:cd17312 103 LFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVP-GIVGLVVAIILF------ 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 206 pqrgtydgWGMIlqataiasgfwglnlaqqsgfDDPVVLSTLALAVvaliafigfeqrqqapllplrifrvriftlgvvt 285
Cdd:cd17312 176 --------FFLR---------------------DSPPYVWVLSLAY---------------------------------- 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 286 vFFIFMVQFFSTVLMPFYLEDARGLTPGTAGTLLSLYPLMMVFFAPFGGWLADKWnVPAVALLGSIFIAVGSLIGATLKS 365
Cdd:cd17312 193 -AFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKL-FGGRRAPIAVIYMLLMTLSLALFW 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 366 NAPLTIYIISTLLVGIGSGLFqspigdvvmsvVPKNQLGIAGSFNALARNlgmVSGTAVATTVLFGTmsqlAGSRVTNYP 445
Cdd:cd17312 271 FFPHNKLLSIVLLFLIGFFVG-----------GPINLIGGAAAQDIGRKE---AAGTATGFVGLFGY----LGASLAGLP 332
|
410 420
....*....|....*....|....*.
gi 227189595 446 TAH--PEFFISGLQVAMIVAAVLAIL 469
Cdd:cd17312 333 LGYiiDHYGWSTVFYFLISAALLSVL 358
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
283-474 |
2.15e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 46.43 E-value: 2.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 283 VVTVFFIFMVQFFSTVLMPFYLEDArGLTPGTAGTLLSLYPLMMVFFAPFGGWLADKWNVPAVALLGSIFIAVGSLIGAT 362
Cdd:cd17489 2 LLANFFFFLSFYLLLPVLPLYAHDL-GGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 363 LKSnapLTIYIISTLLVGIGSGLFQSPIGDVVMSVVPKNQLGIAGSFNALARNLGMVSGTAVattvlfgtmsqlaGSRVT 442
Cdd:cd17489 81 ATS---VALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPAL-------------GLFLY 144
|
170 180 190
....*....|....*....|....*....|..
gi 227189595 443 NYptahpeffiSGLQVAMIVAAVLAILGAIAI 474
Cdd:cd17489 145 QH---------LGFAVLFIVAAVLALLALLLV 167
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
21-177 |
3.57e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 46.05 E-value: 3.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 21 APKRWWLLVALGFFAFMTNldgSIVNIAVPIMAKD-LKVPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIFKWGTG 99
Cdd:COG2211 226 KNRPFLLLLLAYLLFFLAL---ALVAALLLYYFKYvLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLL 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 100 TFVLGSLMAGINLGFNF--LMLARMIQALGGAMTLANTYGIVTSTFALAE-------RGRAMGVVSTFVALGGVAGPSLG 170
Cdd:COG2211 303 LAALGLLLLFFLGPGNLwlLLVLAALAGIGLGAILVLPWAMLADVVDYDEwktgrrrEGLYFGIFTFAIKLGQALAGALA 382
|
....*..
gi 227189595 171 GLILAHF 177
Cdd:COG2211 383 GLLLALF 389
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
271-425 |
5.00e-05 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 45.24 E-value: 5.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 271 LRIFRVRIFTLGVVTVFFIFMVQFFSTVLMPFYLEDaRGLTPGTAGTLLSLYPLMMVFFAPFGGWLADKWNVPAVALLGS 350
Cdd:cd17352 177 LRLLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKS-LGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIF 255
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 227189595 351 IFIAVGSLIGATLKSNApLTIYIISTLLVGIGSGLFQSPIGDVVMSVVPKNQLGIAGSFNALARNLGMVSGTAVA 425
Cdd:cd17352 256 TLLILGLSLLAFPLATT-YVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIA 329
|
|
| PRK03545 |
PRK03545 |
putative arabinose transporter; Provisional |
25-199 |
5.35e-05 |
|
putative arabinose transporter; Provisional
Pssm-ID: 179591 [Multi-domain] Cd Length: 390 Bit Score: 45.27 E-value: 5.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 25 WWLLVALGFFAFMTNLDGSIVNIAVPIMAKDLKVPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIFKWGTGTFVLG 104
Cdd:PRK03545 8 WLRVVTLALAAFIFNTTEFVPVGLLSDIAQSFHMQTAQVGLMLTIYAWVVALMSLPLMLLTSNVERRKLLIGLFVLFIAS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 105 SLMAGINLGFNFLMLARMIQALGGAMTLANTYGIVTSTFALAERGRAMGVVSTFVALGGVAGPSLGGLILAHFSWPMIFL 184
Cdd:PRK03545 88 HVLSALAWNFTVLLISRIGIAFAHAIFWSITASLAIRVAPAGKKAQALSLLATGTALAMVLGLPLGRVIGQYLGWRTTFL 167
|
170
....*....|....*
gi 227189595 185 InvpIGLIALGVSLW 199
Cdd:PRK03545 168 A---IGGGALITLLL 179
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
79-199 |
7.16e-05 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 44.90 E-value: 7.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 79 LPFGKLGDRIGKQRIFKWGTGTFVLGSLMAGINLGFNFLMLARMIQALGGamtlantygIVTSTFALA-------ERGRA 151
Cdd:cd17472 50 IPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGA---------ISSVVMALLadltreeNRTKA 120
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 227189595 152 MGVVSTFVALGGVAGPSLGGLILAHFSWPMIFLINVPIGLIALGVSLW 199
Cdd:cd17472 121 MALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLF 168
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
26-198 |
8.61e-05 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 44.51 E-value: 8.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 26 WLLVALGFFAFMTNLDGSIVNIAVPIMAKDLKVPASQMeWTVSLYLIVLS-ALLLPFGKLGDRIGKQR-IFKWGTGTFVL 103
Cdd:cd17472 194 KRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQL-WKVYLPAILIGfILMVPFVIYAEKKGKMKqVFVSSILLIAV 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 104 GSLMAGINLGFNFLMLARMIQALGGAMTLANTYGIVTSTFALAE-RGRAMGVVSTFVALGGVAGPSLGGLILAHFSWPMI 182
Cdd:cd17472 273 GFLLLLFAATSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEyRGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSV 352
|
170
....*....|....*.
gi 227189595 183 FLINVPIGLIALGVSL 198
Cdd:cd17472 353 FLTILILALLWLLVSF 368
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
23-165 |
9.39e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 44.58 E-value: 9.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 23 KRWWLLVALGFFAFMTNldGSIVNIAVPIMAKDLKVPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIFKWGTGTFV 102
Cdd:COG2814 207 PRLLLLLLLAFLLGFGF--FALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLA 284
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 227189595 103 LGSLMAGINLGFNFLMLARMIQALGGAMTLANTYGIVTSTFALAERGRAMGVVSTFVALGGVA 165
Cdd:COG2814 285 LGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
304-385 |
1.41e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 44.09 E-value: 1.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 304 LEDARGLTPGTAGTLLSLYPLMMVFFAPFGGWLADKWNVPAVALLGSIFIAVGSLIGATLKSnapLTIYIISTLLVGIGS 383
Cdd:COG2807 44 IRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPS---VALLLAGTALIGAGI 120
|
..
gi 227189595 384 GL 385
Cdd:COG2807 121 AV 122
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
287-486 |
1.41e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 43.95 E-value: 1.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 287 FFIFMVQFFSTVLMPFYLEDArGLTPGTAGTLLSLYPLMMVFFAPFGGWLADKWNVPAVALLGSIFIAVGSLIGATLKSn 366
Cdd:cd06174 6 FLTGLARGLISPLLPALLQSF-GLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPS- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 367 apLTIYIISTLLVGIGSGLFQSPIGDVVMSVVPKNQLGIAGSFNALARNLGMVSGTAVATTVLfgtmsqlagsrvtnypt 446
Cdd:cd06174 84 --FWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILA----------------- 144
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 227189595 447 ahpEFFISGLQVAMIVAAVLAILGAIAIGLTIKPWQAHEK 486
Cdd:cd06174 145 ---SSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESAR 181
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
25-384 |
1.43e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 44.18 E-value: 1.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 25 WWLLVALGFFAFMTNLDGSIVNIAVPIMAKDLKVPASQMEWTVSLYLIvLSALLLPF-GKLGDRIGKQRIFKWGTGTFVL 103
Cdd:cd17355 2 WVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLL-AFGLAQPFvGRLLDRFGPRRVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 104 GS-LMAGINLGFNFLMLARMIQALGGAMTLANTYGIVTSTFALAERGRAMGVVSTFVALGGVAGPSLGGLILAHFSWpmi 182
Cdd:cd17355 81 GLvLLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGW--- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 183 flinvpiglialgvslwsmnngipqRGTYDGWGMILQATAIASGFWGLNLaqqsgfddpvvLSTLALAVVALIAFigfeq 262
Cdd:cd17355 158 -------------------------RTALLVLALLALLVLVPVLLLLRRR-----------PADLALRAYDDASP----- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 263 rQQAPLLPLRIFRVRIFTLGVVTVFFIFMVQFFSTVLMPFYLEDaRGLTPGTAGTLLSLYPLMMVFFAPFGGWLADKWNV 342
Cdd:cd17355 197 -ASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLAD-RGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSP 274
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 227189595 343 PAVALLgsIFIAVGSLIGATLKSNAPLTIYIISTLLVGIGSG 384
Cdd:cd17355 275 RRLLAA--SYALRALGLALLLLLPFPPLALLLFAALFGLGWG 314
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
26-198 |
2.38e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 43.31 E-value: 2.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 26 WLLVALGFFAFMTNLdgSIVNIAVPIMAKDLKVPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIFKWGTGTFVLGS 105
Cdd:cd17324 201 RLAYLITFLLFGGFF--ALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALL 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 106 LMAGINLGFNFLMLARMIQALGGAMTLANTYGIVTSTfALAERGRAMGVVSTFVALGGVAGPSLGGLILAHFSWPMIFLI 185
Cdd:cd17324 279 LLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRL-APEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWV 357
|
170
....*....|...
gi 227189595 186 NVPIGLIALGVSL 198
Cdd:cd17324 358 GAALLLLALLLAL 370
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
287-390 |
2.54e-04 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 43.34 E-value: 2.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 287 FFIFMVQFFSTVLMPFYLEDaRGLTPGTAGTLLSLYPLMMVFFAPFGGWLADKWNVPAVALLGSIFIAVGSLIGATLKSN 366
Cdd:cd17335 7 FFFFAALGSLLPFLSVYLKQ-LGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSLFFVAQ 85
|
90 100
....*....|....*....|....
gi 227189595 367 APLTIyiistLLVGIGSGLFQSPI 390
Cdd:cd17335 86 IFWLL-----LLLVILGAFFSAPV 104
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
25-199 |
2.70e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 42.98 E-value: 2.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 25 WWLLVALGFFAFMTNLdgsiVNIAVPIMAKDLK-VPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIFKWGTGTFVL 103
Cdd:cd17329 203 LLFLLASFLISLIYFQ----LESTLPVYVVEILgLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAI 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 104 GSLMAGINLGFNFLMLARMIQALGGAMTLANTYGIVTSTFALAERGRAMGVVSTFVALGGVAGPSLGGLILAHFSWPMIF 183
Cdd:cd17329 279 GFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPW 358
|
170
....*....|....*.
gi 227189595 184 LINVPIGLIALGVSLW 199
Cdd:cd17329 359 LILAALGLIAAALLLG 374
|
|
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
112-384 |
3.15e-04 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 42.98 E-value: 3.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 112 LGFNFLMlaRMIQALGGAMTLANTYGIVTSTFAlAERGRAMGVVSTFVALGGVAGPSLGGLILAHFSWPMIFLInvpIGL 191
Cdd:cd17385 94 IALCFLV--RIVEAVGFAAFITASFAIIAKEFP-NNIATVLGTLETFSGLGLMLGPPLGGFLYQAGGYELPFLV---LGC 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 192 IALGVSLWSMNNGIPQRGTydgwgmilqATAIASGFWGLnlaqqsgFDDPVVLsTLALAVVALIAFIGFEQRQQAPllpl 271
Cdd:cd17385 168 LLLLTVPLNMFILPRYDDD---------PSPKSGSMLKL-------LKIPSVL-LLCLSIVSGSVSLGFLDPTLSP---- 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 272 rifrvriftlgvvtvffiFMVQFfstvlmpfyledarGLTPGTAGTLLSLYPLMMVFFAPFGGWLADKWNVPAVAL-LGS 350
Cdd:cd17385 227 ------------------HLRQF--------------KLSPGQVGLMFLILAGSYAISAPLWGWLSDKKKIPKWLMvIGS 274
|
250 260 270
....*....|....*....|....*....|....*..
gi 227189595 351 IFIAVG-SLIGAT--LKSNAPLTIYIISTLLVGIGSG 384
Cdd:cd17385 275 IITGVGfLLLGPAplLPIKSELWMVIIGLVLLGLSLG 311
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
298-476 |
3.99e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 42.61 E-value: 3.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 298 VLMPFyLEDARGLTPGTAGTLLSLYPLMMVFFAPFGGWLADKWNVPAVALLGSIFIAvGSLIGATLKSNAPLTIYIIstL 377
Cdd:cd17475 17 ALAPF-LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMG-AAALLMALVGSYPVLLVLL--F 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 378 LVGIGSGLFQSPIGDVVMSVVPKNQLGIAGSFnalaRNLGMVSGTAVATTVLfgtmsqlagsrvtnyptahPEFFI-SGL 456
Cdd:cd17475 93 LVGAGYGSVQPGGGRAIMRWFPPRERGLAMGI----RQTGVPLGGALAAALL-------------------PPLALhYGW 149
|
170 180
....*....|....*....|
gi 227189595 457 QVAMIVAAVLAILGAIAIGL 476
Cdd:cd17475 150 RAAFVVAGLVSILAAVLFWL 169
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
66-355 |
5.11e-04 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 42.29 E-value: 5.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 66 TVSLYLIVLSALLLPFGKLGDRIGKQRIFKWGTGTFVLGSLMAGINLGFNFLMLARMIQALGGAMTLANTYGIVTSTFAL 145
Cdd:cd17371 39 LGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPA 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 146 AERGRAMGVVSTFVALGGVAGPSLGGLILAHFS----WPMIFLINVPIGLIALGVSLWsmnngipqrgtydgwgmiLQAT 221
Cdd:cd17371 119 RHRGKALGYVQSGWAVGWLLATLLAALLFPLLPpeiaWRVLFLLGALPALLVLFIRRF------------------VKEP 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 222 AIasgfWGLNLAQQSGFDDPVVLSTLalavvaliafigfeqrQQAPLLplrifrvRIFTLGVVTVFFIFMVQFFSTVLMP 301
Cdd:cd17371 181 PQ----WQAARAARRHFADRPSLREL----------------FSPPLL-------RTTLLASLLATGALGGYYGITTWLP 233
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 227189595 302 FYLEDARGLTPGTAGTLLSLYPLMMVFFAPFGGWLAD----KWNVPAVALLGSIFIAV 355
Cdd:cd17371 234 SYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADrigrRNNFALFALGSAISILL 291
|
|
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
82-207 |
5.87e-04 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 42.17 E-value: 5.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 82 GKLGDRIGKQRIFKWGTGTFVLGSLMAGINLGFNFLMLARMIQALGGAMTLANTYGIVTSTFAL-AERGRAMGVVSTFVA 160
Cdd:cd17384 52 GPLTNRIGYSLPMFVGFVIMFISTLLFAFGESYGVLFLARALQGVGSACSSVAGMGMLASLYPDdKERGKAMGIALGGLA 131
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 227189595 161 LGGVAGPSLGGLI--LAHFSWPmiFLINVPIGLIALGVSLWSMNNGIPQ 207
Cdd:cd17384 132 LGVLVGPPFGGVMyeFVGKSAP--FLILAFLALLDGALQLFILQPSVKS 178
|
|
| PTR2 |
COG3104 |
Dipeptide/tripeptide permease [Amino acid transport and metabolism]; |
282-386 |
6.01e-04 |
|
Dipeptide/tripeptide permease [Amino acid transport and metabolism];
Pssm-ID: 442338 [Multi-domain] Cd Length: 479 Bit Score: 42.11 E-value: 6.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 282 GVVTVFFIFMVQFFS----TVLMPFYL-----EDARGLTPGTAGTLLSLYpLMMVFFAP-FGGWLADKW--NVPAVaLLG 349
Cdd:COG3104 15 GLYTLFFTEMWERFSfygmRAILVLYLtaslaDGGLGLSEADAAAIYGAY-TALVYLTPlLGGWLADRLlgQRRAI-LLG 92
|
90 100 110
....*....|....*....|....*....|....*..
gi 227189595 350 SIFIAVGSLIGATlksNAPLTIYIISTLLVGIGSGLF 386
Cdd:COG3104 93 GILMALGHFLLAL---PGGVTLFYLGLALIAVGNGLF 126
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
23-200 |
6.06e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 42.22 E-value: 6.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 23 KRWWLLVALGFFAFMTNLDGSIVNIAVPIMAKD-LKVPASQMEWTVSLYLI--VLSALLLpfGKLGDRIGKQRIFKWGTG 99
Cdd:cd06173 205 RRSPLLRLLLLALALFALLGGALTVLLPLLAKEvLGGGAAGYGLLLAAFGVgaLLGALLL--GRLSKRRRRGRLLLIGAL 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 100 TFVLGSLMAGINLGFNFLMLARMIQALGGAMTLANTYGIVTSTFALAERGRAMGVVSTFVALGGVAGPSLGGLILAHFSW 179
Cdd:cd06173 283 LLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGL 362
|
170 180
....*....|....*....|.
gi 227189595 180 PMIFLINVPIGLIALGVSLWS 200
Cdd:cd06173 363 SAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
68-201 |
8.79e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 41.43 E-value: 8.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 68 SLYLIVLSALLLPFGKLGDRIGKQRIFKWGTGTFVLGSLMAGINLGFNFLMLARMIQALG-GAMTLANTYGIVTSTFAlA 146
Cdd:cd17489 234 TVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGfGLLFPALQALAVDLVPP-H 312
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 227189595 147 ERGRAMGVVSTFVALGGVAGPSLGGLILAHFSWPMIFLINVPIGLIALGVSLWSM 201
Cdd:cd17489 313 RRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
284-480 |
9.03e-04 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 41.41 E-value: 9.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 284 VTVFFIFMVQFFSTVLMPFYLEDArGLTPGTAGTLLSLYPLMMVFFAPFGGWLADKWNVPAVALLGSIFIAVGSLIGATL 363
Cdd:cd17325 3 LALFLDMLGYGIIIPILPLYAESL-GASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 364 KSnapLTIYIISTLLVGIGSGLFQSPIGDVVMSVVPKNQLGIAGSFNALARNLGMVSGTAVATTVlfgtmsqlagsrvtn 443
Cdd:cd17325 82 TS---YWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLL--------------- 143
|
170 180 190
....*....|....*....|....*....|....*..
gi 227189595 444 yptahpeFFISGLQVAMIVAAVLAILGAIAIGLTIKP 480
Cdd:cd17325 144 -------ADALGYRAPFLVCAALALLALVLALLLLPE 173
|
|
| MFS_DtpA_like |
cd17346 |
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ... |
285-394 |
9.08e-04 |
|
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 41.41 E-value: 9.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 285 TVFFIFMVQFFST----VLMPFYLEDA--RGLTPGTAGTLLSLYPLMMVFFAPFGGWLADKW--NVPAVaLLGSIFIAVG 356
Cdd:cd17346 6 TLFFTEMWERFSYygmrAILILYLTAQlgDGFSEADAASIYGAYTALVYLTPIIGGWLADKVlgARRTV-FIGGILMALG 84
|
90 100 110
....*....|....*....|....*....|....*...
gi 227189595 357 SLIGATLKSNAPLTIYIIstLLVGIGSGLFQSPIGDVV 394
Cdd:cd17346 85 YLLLALSPFSVSMLYLGL--ALIIVGNGLFKPNISSLV 120
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
80-201 |
9.28e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 41.41 E-value: 9.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 80 PFGKLGDRIGKQRIFKWGTGTFVLGSLMAGINLGFNFLMLARMIQALGGAmTLANTYGIVTSTFALAERGRAMGVVSTFV 159
Cdd:cd17330 53 LWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGG-NVSVAQAYIADITDEEERAKAFGIISAAF 131
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 227189595 160 ALGGVAGPSLGGLILAHFSWPMIFLINVPIGLIALGVSLWSM 201
Cdd:cd17330 132 GLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFL 173
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
26-442 |
1.55e-03 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 40.70 E-value: 1.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 26 WLLVALGFFAFMtnldgsIVNIAVPIMAKDLKVPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIFkwgtgTFVLGS 105
Cdd:cd17341 5 WLSFFLGFMVWF------LFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVF-----IASLLL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 106 LMAGInlgfnfLMLARMIQALGGAMTLANTYGIVTSTFALaergrAMGVVSTFV-------ALGGVAGPSLGGLILAHFS 178
Cdd:cd17341 74 LLIPL------LALALAVSSYWGLLVLGFLLGFAGANFAS-----GQPWASFWFpkekiggAAGGIAGAGNMGVAVSQLL 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 179 WPMIFlinvPIGLIALGVSLWsmnngipqRGTYDGWGMILQATAIASGFWGLNLAQQSGFDDPVVLSTLAlavvaliafi 258
Cdd:cd17341 143 APLIA----GAIVFDGGFVGW--------RNAFFVPGILLAIAAVLVLLFGDDLPTGKASALEFLKVQLA---------- 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 259 gfeqrqqapllPLRIFRVRIFTLGVVTVFFIFMVqfFSTVLmPFYLEDARGLTPGTAGTLLSLYPLMMVFFAPFGGWLAD 338
Cdd:cd17341 201 -----------VLKNYRTWILSLLYGVTFGSFVG--FSNVL-PTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSD 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 339 KWNVPAVALLGSIFIAVGSLIGATL--KSNAPLTIYIISTLLVGIGSGLFQSpigdVVMSVVP---KNQLGIAGSFNALA 413
Cdd:cd17341 267 RFGGRRRLWWLFIVMTIGAALLSLSlpTSGTNLVLFLALFVALGLGAGAGNG----SVFRMVPfifRRELGAVTGLVGAI 342
|
410 420
....*....|....*....|....*....
gi 227189595 414 RNLGmvsgtAVATTVLFGTMSQLAGSRVT 442
Cdd:cd17341 343 GGLG-----GFFLPLLFGSSALMTGSGVG 366
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
67-434 |
1.82e-03 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 41.06 E-value: 1.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 67 VSLYLIVLSALLLPF-------GKLGDRIGKQRIFKWGTGTFVLgsLMAGINLG-----FNFLMLARMIQALGGAMTLAN 134
Cdd:PRK08633 46 VILTAIVNALFLLPFlllsspaGFLADKFSKNRVIRIVKLFEVG--LTLLIVLAyylgwFWLAFAVTFLLGAQSAIYSPA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 135 TYGIVTSTFALAERGRAMGVVSTFVALGGVAGPSLGGLILAHF--SWPMIFLINV-PIGLIALGVSL--WSMNNGIPQRG 209
Cdd:PRK08633 124 KYGIIPELVGKENLSRANGLLEAFTIVAILAGTALFSFLFESVngNTPSEILGRIaPAGLVLLAVAVlgLIFAYRLPKVP 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 210 TYDGWGMILQATAIASGFWG-LNLAQQSGFddpvvlstLALAVVALiafigfeqrqqapllplrifrvriftlgvvtVFF 288
Cdd:PRK08633 204 AAAPEVFDKKKYLFPKLLWRnLKLLRSDRV--------LWLAIIGL-------------------------------SYF 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 289 IFMVQFFSTVLMPFYLEDArgltpGTAGTLLSLYPLMMVFFA-PFGGWLADKWNVPAVAL----LGSIFIAVGSLIGATL 363
Cdd:PRK08633 245 WFISQLAQANFPAYAKEVL-----GLDNTFQVQYLLAASAIGiGIGSLLAGRLSGRHIELglvpLGALGLALSLFLLPTA 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 227189595 364 KSnapLTIYIISTLLVGIGSGLFQSPIGDVVMSVVPKNQLG--IAGsfNALARNLGMVSGTAVATTVLFGTMS 434
Cdd:PRK08633 320 PS---LASVLVLFFLFGFSAGLFIVPLNALIQFRAPEKELGkvLAA--NNFLQNVGMLLFLALTTLFSGLGLS 387
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
277-479 |
2.66e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 40.27 E-value: 2.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 277 RIFTLGVVTVFFIFMVQFFSTVLMPFYLEDArGLTPGTAGTLLSLYPLMMVFFAPFGGWLADKWNVP-----AVALLGSI 351
Cdd:COG2211 11 EKLAYGLGDLGLNLAFGLLSAYLLYFYTDVL-GLSAALVGLILLVARLWDAITDPLIGALSDRTRTRwgrrrPWILIGAI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 352 FIAVGSL---IGATLKSNAPLTIYIISTLLVGIGSGLFQSPIGDVVMSVVP-KNQLGIAGSFnalaRNLGMVSGTAVATT 427
Cdd:COG2211 90 PLALSFVllfTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPdYEERTRLSSW----RFAFAGLGGLLASV 165
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 227189595 428 VLFGTMSQLAGSRVTNYptahpeffisglQVAMIVAAVLAILGAIAIGLTIK 479
Cdd:COG2211 166 LPPPLVAAFGGDAALGY------------RLTALIFAVLGLLAFLLTFFGTK 205
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
24-199 |
3.23e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 39.51 E-value: 3.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 24 RWWLLVALGFFAFMTNLDGSIVNIAVPIMAKDLKVPASQMEWTVSLYLIVLSALLLPFGKLGDRIGKQRIFKWGTGTFVL 103
Cdd:cd17316 176 RRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGI 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 104 GSLMAGINL--GFNFLMLARMIQALGGAMTLANTYGIVTSTFALAERGRAMGVVSTFVALGGVAGPSLGGLILAHFSWPM 181
Cdd:cd17316 256 LALPLFYLLsgSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTG 335
|
170
....*....|....*...
gi 227189595 182 IFLINVPIGLIALGVSLW 199
Cdd:cd17316 336 VPALILALLAIVALIVAL 353
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
299-480 |
3.29e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 39.48 E-value: 3.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 299 LMPFYLEDAR--GLTPGTAGTLLSLYPLMMVFFAPFGGWLADKWNVPAVALLGSIFIAVGSLIGATLKSnapLTIYIIST 376
Cdd:cd17330 18 VLPFYVREFNklGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRN---LWLLFLAR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227189595 377 LLVGIGSGLFqSPIGDVVMSVVPKNQLGIAGSFNALARNLGMVSGTAVATTVLfgtmsqlagsrvtnyptahpefFISGL 456
Cdd:cd17330 95 FLDGLTGGNV-SVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLS----------------------TPYGY 151
|
170 180
....*....|....*....|....
gi 227189595 457 QVAMIVAAVLAILGAIAIGLTIKP 480
Cdd:cd17330 152 ALPFLVAAALALLNLVLVLFFLPP 175
|
|
| |
