|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
14-397 |
7.27e-44 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 156.96 E-value: 7.27e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 14 LSASFMVTSAYAIQSALPQIKSA-LNVSQPQVEYLVTAPSFAVMFFVVLSPLLQDWFniSDKHIIMAGITIVGIAGLIPS 92
Cdd:cd17473 6 LASTLTVMAGAAIAPALPAIAQHfVPNSELLVPLLLTLPALFIALFAPLAGWLADRF--GRKRLLIAGLLLYGIGGVAGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 93 FVSNYMVILISRLFLGAGYGLYNSQAISLISVWYQDHERTSMQGWRSAFEQIGNAcTLTISSLLLIYAGWHAAFLVYGLA 172
Cdd:cd17473 84 FLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGV-VFLLLGGALAEIGWRAPFLVYLLA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 173 FAVMAFFAWRVPNDAHSNTTTSDNQQATETISPItnepvtkisPLVIAILAFVLLIKMDFIGMEDRFPGLAVAINGKTFT 252
Cdd:cd17473 163 LPVLILVLLFLPEPARKSKSAASPGAATAAALPW---------KRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 253 GTGTYLSLMLIGATLGGACYGVLQKHFGYVGTIYIGLILLAIANFLFGFGGNsFPIIAAGILLVGFPMQVLTPLIFNILP 332
Cdd:cd17473 234 LIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASG-LWVVLLGAILAGLGFGLLLPTLNSWAM 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 227351252 333 FMAPMKLQTKVTSFVLIGFNFGAFFSPtadawfnhLLSQPL--NGLGLAAPFRIYGVMMLIIAGLLF 397
Cdd:cd17473 313 SLVPPELRGRAMGIVTSAFFLGQFLSP--------LVLGPLvnLTGGLSGAFLILGVLALVLAIVLL 371
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
4-355 |
5.34e-27 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 110.45 E-value: 5.34e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 4 SQSLATKLAFLSASFMVTSAYAIQSALPQIKSALNVSQPQVEYLVTAPSFAVMFFVVLSPLLQDWFNIsdKHIIMAGITI 83
Cdd:COG2814 7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGR--RRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 84 VGIAGLIPSFVSNYMVILISRLFLGAGYGLYNSQAISLISVWYQDHERTSMQGWRSAFEQIGNACTLTISSLLLIYAGWH 163
Cdd:COG2814 85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 164 AAFLVYGLAFAVMAFFAWRVPNDAHSNTTTSDNQQATETISpitnepvtkiSPLVIAILAFVLLIKMDFIGMEDRFPGLA 243
Cdd:COG2814 165 WVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLR----------RPRLLLLLLLAFLLGFGFFALFTYLPLYL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 244 VAINGKTFTGTGTYLSLMLIGATLGGACYGVLQKHFGYVGTIYIGLILLAIANFLFGFGGnSFPIIAAGILLVGFPMQVL 323
Cdd:COG2814 235 QEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAG-SLWLLLLALFLLGFGFGLL 313
|
330 340 350
....*....|....*....|....*....|..
gi 227351252 324 TPLIFNILPFMAPMKLQTKVTSFVLIGFNFGA 355
Cdd:COG2814 314 FPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
11-398 |
7.65e-24 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 102.27 E-value: 7.65e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 11 LAFLSASFMVTSAYAIQSALPQIKSALNVSQPQVEYLVTAPSFAVMFFVVLSPLLQDWFniSDKHIIMAGITIVGIAGLI 90
Cdd:COG2223 9 LATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRF--GPRRVLLIGLLLLGIGLLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 91 PSFVSNYMVILISRLFLGAGYGLYNSQAISLISVWYQDHERTSMQGWRSAFEQIGNACTLTISSLLLIYAGWHAAFLVYG 170
Cdd:COG2223 87 LALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILG 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 171 LAFAVMAFFAWRVPNDAHSNTTTSDNQQATETISPITNEPVTKISPL-VIAILAFVLLIKMdfigmedrFPGLAVAINGK 249
Cdd:COG2223 167 ILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEALRDPRFWLLSLLyFGTFGSFIGFSSW--------LPPYLVDQFGL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 250 TFTGTGTYLSLMLIGATLGGACYGVLQKHFGYVGTIYIGLILLAIANFLFGFGGNSFPIIAAGILLVGFPMQVLTPLIFN 329
Cdd:COG2223 239 SAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFA 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 227351252 330 ILPFMAPMKLQTKVTSFVLIGFNFGAFFSPTADAWFNHLLSqplnglGLAAPFRIYGVMMLIIAGLLFM 398
Cdd:COG2223 319 LVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATG------SYTAAFLVFAVLALVALVLTLL 381
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
11-398 |
8.32e-21 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 93.01 E-value: 8.32e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 11 LAFLSASFMVTSAYAIQSALPQIKSALNVSQPQVEYLVTAPSFAVMFFVVLSPLLQDWFNIsdKHIIMAGITIVGIAGLI 90
Cdd:COG2271 14 LLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGR--RRVLAIGLLLWGLATLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 91 PSFVSNYMVILISRLFLGAGYGLYNSQAISLISVWYQDHERTSMQGWRSAFEQIGNACTLTISSLLLIYAGWHAAFLVYG 170
Cdd:COG2271 92 FGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILG 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 171 LAFAVMAFFAwrvpndahsntttsdnqqatetispitnepvtkisplVIAILAFVLLIKMDFIGMEDRFPGLAVAINGKT 250
Cdd:COG2271 172 LPGLLLALLR-------------------------------------FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLS 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 251 FTGTGTYLSLMLIGATLGGACYGVLQKHFGYVGTIYIGLILLAIANFLFGFG-GNSFPIIAAGILLVGFPMQVLTPLIFN 329
Cdd:COG2271 215 LAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLAlLPSPALAIALLFLAGFGLGGAFGLLWA 294
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 227351252 330 ILPFMAPMKLQTKVTSFVLIGFNFGAFFSPTADAWFnhllsqpLNGLGLAAPFRIYGVMMLIIAGLLFM 398
Cdd:COG2271 295 LAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYL-------LDATGYQAAFLLLAALALLAALLALL 356
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
13-359 |
3.30e-20 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 90.94 E-value: 3.30e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 13 FLSASFMVTSAYAIQSALPQ-IKSALNVSQPQVEYLVTAPSFAVMFFVVLSPLLQDwfNISDKHIIMAGITIVGIAGLIP 91
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSD--RFGRRRVLLIGLLLFALGLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 92 SFVSNYMVILISRLFLGAGYGLYNSQAISLISVWYQDHERTSMQGWRSAFEQIGNACTLTISSLLLIYAGWHAAFLVYGL 171
Cdd:pfam07690 80 LFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 172 AFAVMAFFAWRVPNDAHSNTTTSDNQQATETISPITNEPVTKISPLVIAILAFVLLIKMDFIGMedrfPGLAVAINGKTF 251
Cdd:pfam07690 160 LSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYL----PLYQEVLGLSAL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 252 TGTGTYLSLMLIGATLGGACyGVLQKHFGYVGTIYIGLILLAIANFLFGF--GGNSFPIIAAGILLVGFPMQVLTPLIFN 329
Cdd:pfam07690 236 LAGLLLGLGGLLGAIGRLLL-GRLSDRLGRRRRLLLALLLLILAALGLLLlsLTLSSLWLLLALLLLGFGFGLVFPALNA 314
|
330 340 350
....*....|....*....|....*....|
gi 227351252 330 ILPFMAPMKLQTKVTSFVLIGFNFGAFFSP 359
Cdd:pfam07690 315 LVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
11-398 |
9.11e-18 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 84.16 E-value: 9.11e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 11 LAFLSASFMVTSAYAIQSALPQIKSALNVSQPQVEYLVTAPSFAVMFFVVLSPLLQDWFniSDKHIIMAGITIVGIAGLI 90
Cdd:cd17474 3 AVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRF--GRKKVLLPGLLLFGIGGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 91 PSFVSNYMVILISRLFLGAGYGLYNSQAISLISVWYQDHERTSMQGWRSAFEQIGNACTLTISSLLLiYAGWHAAFLVYG 170
Cdd:cd17474 81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYPFFLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 171 LAFAVmAFFAWRVPNDAHSNTTTSDNQQATETISPITNEPVTkispLVIAILAFVLLIKmdFIGMEDRFPGLAVAINGKT 250
Cdd:cd17474 160 ALIPV-AFLAILFLLPEPKEKAKSSSATKLRDLKKALRGRGL----LTFLVSAFLYFFL--YFAFLTYLPFLLELLYGIS 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 251 FTGTGTYLSLMLIGATLGGACYG-VLQKHFGYVGTIYIGLILLAIANFLFGFgGNSFPIIAAGILLVGFPMQVLTPLIFN 329
Cdd:cd17474 233 PIIIGLLFAGWSVLLALGSLFVGrLLKKRFGARRILVIGLLLYALSLLLLGF-VPSLALLLIAIVLFGLGLGLNLPLLTT 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 227351252 330 ILPFMAPMKLQTKVTSFvligFNFGAFFSPTADAWFNHLLSQplnGLGLAAPFRIYGVMMLIIAGLLFM 398
Cdd:cd17474 312 LVTELAPEEERGTASSL----YNFVRFLGQAVGPLLFGLLLE---IFGLSAPFLVGAAIALAAAVLLAL 373
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
13-400 |
3.59e-17 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 82.62 E-value: 3.59e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 13 FLSASFMVTSAYAIQSALPQIKSALNVSQPQVEYLVTAPSFAVMFFVVLSPLLQDwfNISDKHIIMAGITIVGIAGLIPS 92
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSD--RFGRKRLLLLGLLLLAVSTLLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 93 FVSNYMVILISRLFLGAGYGLYNSQAISLISVWYQDHERTSMQGWRSAFEQIGNACTLTISSLLLIYAGWHAAFLVYGLA 172
Cdd:cd17325 80 FATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 173 FAVMAFFAWRVPNDAHSNTTTSDNQQATETISPITnepvTKISPLVIAILAFVLLIKMDFIGMEDRFPGLAVAINGKTFT 252
Cdd:cd17325 160 ALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRL----LLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 253 GTGTYLSLMLIGATLGGACYGVLQKHFGYVGTIYIGLILLAIANFLFGFGGnSFPIIAAGILLVGFPMQVLTPLIFNILP 332
Cdd:cd17325 236 QIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLAT-SFWLLLLLLALLGLGLGLVFPATLALLA 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 227351252 333 FMAPMKLQTKVTSFVLIGFNFGAFFSPTADAWFNHLlsqplngLGLAAPFRIYGVMMLIIAGLLFMGK 400
Cdd:cd17325 315 DIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDA-------FGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
28-400 |
8.22e-16 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 78.74 E-value: 8.22e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 28 SALPQIKSALNVSQPQVEYLVTAPSFAVMFFVVLSPLLQDWFNIsdKHIIMAGITIVGIAGLIPSFVSNYMVILISRLFL 107
Cdd:COG0738 29 PLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGY--KRGLLLGLLLMALGLLLFALAPSYPLLLLALFLL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 108 GAGYGLYNSQAISLISVWYQDHERTSMqGWRSAFEQIGNACTLTISSLLL---IYAGWHAAFLVYGLAFAVMAFFAWRVP 184
Cdd:COG0738 107 GLGLGLLDVAANPYVAALGPETAASRL-NLLHAFFSLGALLGPLLGGLLIllgLSLSWHLPYLILAVLLLLLALLFLRSK 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 185 NDAHSNTTTSDNQQATETISPITNepvtkisPLVIAILAFVLLIKMDFIGMEDRFPGLAVAINGKTFTGTGTYLSLMLIG 264
Cdd:COG0738 186 LPEIEEEEEEAAGSAASLKSLLKN-------PRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGG 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 265 ATLGGACYGVLQKHFGYVGTIYIGLILLAIANFLFGFGGNsFPIIAAGILLVGFPMQVLTPLIFNILPFMAPMKLQTKVT 344
Cdd:COG0738 259 MTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPG-PWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVS 337
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 227351252 345 SFVLIGFnFGAFFSPTADAWFNHLlsqplngLGLAAPFRIYGVMMLIIAGLLFMGK 400
Cdd:COG0738 338 AVLIMGI-VGGAIGPPLIGFLADA-------FGLRAAFLVPLVCYLLILLLALALK 385
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
13-318 |
1.52e-15 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 77.59 E-value: 1.52e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 13 FLSASFMVTSAYAIQSALPQIKSALNVSQPQVEYLVTAPSFAVMFFVVLSPLLQDwfNISDKHIIMAGITIVGIAGLIPS 92
Cdd:cd17324 5 ALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSD--RIERRRLLLVLLLLFILGNLLAA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 93 FVSNYMVILISRLFLGAGYGLYNSQAISLISVWYQDHERTSMQGWRSAFEQIGNACTLTISSLLLIYAGWHAAFLVYG-L 171
Cdd:cd17324 83 LAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAvL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 172 AFAVMAFFAWRVPNDAHSNTTtsdnqqateTISPITNEPVTKISPLVIAILAFVLLIKMDFIGMEDRFPGLAVAINGKTF 251
Cdd:cd17324 163 ALLAALLLWRLLPSLPPKKPG---------SLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSS 233
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 227351252 252 TGTGTYLSLMLIGATLGGACYGVLQKHFGyVGTIYIGLILLAIANFLFGFGGNSFPIIAAGILLVGF 318
Cdd:cd17324 234 SAIIGLLLLFGVAGVVGSPLAGRLADRGG-RRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGL 299
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
12-365 |
1.20e-14 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 74.77 E-value: 1.20e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 12 AFLSASFMVTSAYAIQSALPQIKSALNVSQPQVEYLVTAPSFAVMFFVVLSPLLQDWFNIsdKHIIMAGITIVGIAGLIP 91
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGR--RPVLLLGLLLFALGALLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 92 SFVSNYMVILISRLFLGAGYGLYNSQAISLISVWYQDHERTSMQGWRSAFEQIGNACTLTISSLLL--IYAGWHAAFLVY 169
Cdd:cd06174 79 AFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFLIA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 170 GLAFAVMAFFAWRVPNDAHsNTTTSDNQQATETISPITNEPVTKISPLVIAILAFVLLIkMDFIGMEDRFPGLAVAINGK 249
Cdd:cd06174 159 AALALLAAILLLLVVPDPP-ESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVN-LAYYSFSTLLPLFLLDLGGL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 250 TFTGTGTYLSLMLIGATLGGACYGVL-QKHFGYVGTIYIGLILLAIANFLFGFGGNsFPIIAAGILLVGFPMQVLTPLIF 328
Cdd:cd06174 237 SVAVAGLLLSLFGLAGALGSLLLGLLsDRLIGRKPLLLIGLLLMALGLALLLLAPS-LLLLLLLLLLLGFGLGGLLPLSF 315
|
330 340 350
....*....|....*....|....*....|....*..
gi 227351252 329 NILPFMAPMKLQTKVTSFVLIGFNFGAFFSPTADAWF 365
Cdd:cd06174 316 ALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFL 352
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
76-336 |
1.23e-11 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 66.08 E-value: 1.23e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 76 IIMAGITIVGIAgLIPSFVSNYMVI--LISRLFLGAGYGLYNSQAISLISVWYQD-HERTSMQGWRSAFEQIGNACTLTI 152
Cdd:COG2211 88 AIPLALSFVLLF-TAPDLSPTGKLIyaLVTYLLLGLAYTLVNIPYSALGAELTPDyEERTRLSSWRFAFAGLGGLLASVL 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 153 SSLLLIY------AGWHAAFLVYGLAFAVMAFFAWRvpndahsntTTSDNQQATETISPITNE--PVTKISPLVIAILAF 224
Cdd:COG2211 167 PPPLVAAfggdaaLGYRLTALIFAVLGLLAFLLTFF---------GTKERPVPEEEKVSLKESlkALLKNRPFLLLLLAY 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 225 VLLikmdFIGMEDR---FPGLAVAINGKTFTGTGTYLSLMLIGATLGGACYGVLQKHFGYVGTIYIGLILLAIANFLFGF 301
Cdd:COG2211 238 LLF----FLALALVaalLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFF 313
|
250 260 270
....*....|....*....|....*....|....*.
gi 227351252 302 -GGNSFPIIAAGILLVGFPMQVLTPLIFNILPFMAP 336
Cdd:COG2211 314 lGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVD 349
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
13-361 |
1.95e-11 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 65.28 E-value: 1.95e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 13 FLSASFMVTSAYAIQSALPQIKSALNVSQPQVEYLVTAPSFAVMFFVVLSPLLQDWFNIsdKHIIMAGITIVGIAGLIPS 92
Cdd:COG2807 24 VLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGL--ERTLLLALLLLAAGLLLRS 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 93 FVSNYMVILISRLFLGAGYGLYNSQAISLISVWYQDHeRTSMQGWRSAFEQIGNACTLTISSLLLIYAGWHAAFLVYG-L 171
Cdd:COG2807 102 LAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWAlL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 172 AFAVMAFFAWRVPNDAHSNTTTSDNQQATETISpitnepvtkiSPLVIAILAFVLLIKMDFIGMEDRFPGLAVAiNGKTF 251
Cdd:COG2807 181 ALLALLLWLPLLRRRPAAAAAAPAAASLRSLWR----------SPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 252 TGTGTYLSLMLIGATLGGACYGVLQKHFGYVGTIYIGLILLAIANFL-FGFGGNSFPIIAAgiLLVGFPMQVLTPLIFNI 330
Cdd:COG2807 250 ATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLgLLLAPGSLPWLWA--VLLGLGQGGLFPLALTL 327
|
330 340 350
....*....|....*....|....*....|..
gi 227351252 331 LPFMAPMKLQT-KVTSFVLIGFNFGAFFSPTA 361
Cdd:COG2807 328 IGLRARTPAEAaALSGMAQSVGYLLAALGPLL 359
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
14-399 |
8.04e-11 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 63.35 E-value: 8.04e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 14 LSASFMVTSAYAIQS-ALPQIKSALNVSQPQVEYLVTAPSFAVMFFVVLSPLLQDWFNIsdKHIIMAGITIVGIAGLIPS 92
Cdd:cd17321 2 LLAVFLAALDVTIVNvALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGR--KRVFLIGLALFGLASLLCA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 93 FVSNYMVILISRLFLGAGYGLYNSQAISLISVWYQDHERTSMQGWRSAFEQIGNACTLTISSLLLIYAGWHAAFLVyGLA 172
Cdd:cd17321 80 LAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLI-NVP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 173 FAVMAFFawrvpndahsntttsdnqqatetispitnepvtkISPLVIAILAFVLLIKMDFIGMEDRFPGLAVAINGKTFT 252
Cdd:cd17321 159 IGLVALL----------------------------------LARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPL 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 253 GTGTYLSLMLIGATLGGACYGVLQKHFGYVGTIYIGLILLAIANFLFGF--GGNSFPIIAAGILLVGFPMQVLTPLIFNI 330
Cdd:cd17321 205 QAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALlgADSSVWLLLPGLVLLGLGLGLFATPLTNA 284
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 227351252 331 LPFMAPMKLQTKVTSFVLIGFNFGAFFSPT-ADAWFNHLLSQPLNGLGLAAPFRI--------YGVMMLIIAGLLFMG 399
Cdd:cd17321 285 ALSSVPKEKAGAASGILNTARQLGGALGVAlLGALLTAGLSANLGDSGVAALLSAaaaafaagFHLAFLVAAALALLA 362
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
11-318 |
2.02e-10 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 61.87 E-value: 2.02e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 11 LAFLSASFMVTSAYAIqsaLPQIKSALNVSQPQVEYLVTAPSFAVMFFVVLSPLLQDWFniSDKHIIMAGITIVGIAGLI 90
Cdd:cd17475 3 LAQAAASLVAQGIPAL---APFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRF--GERRVLAVGLLLMGAAALL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 91 PSFVSNYMVILISRLFLGAGYGLYNSQAISLISVWYQDHERTSMQGWRSAFEQIGNACTLTISSLLLIYAGWHAAFLVYG 170
Cdd:cd17475 78 MALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 171 LAFAVMA--FFAWRVPNDAHSNTTTSDNQQATETISPITNEPVTKISPLVI-------AILAFVLLIKMDFIGMedrfpg 241
Cdd:cd17475 158 LVSILAAvlFWLFYREPPAASAATESASTLLRSLKEVLRNRDVWLIAIAGAllvapqfALLTFLLLFLHDHLGL------ 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 242 lavaingkTFTGTGTYLSLMLIGATLGGACYGVLQKHFG-------YVGTIYIGLILLAIanFLFGFGGNSFPIIAAGIL 314
Cdd:cd17475 232 --------SVVAAGALLAVAQLGGALGRIGLGRVSDRVFggrrrpvLVITAAIAAAALLV--LSLLSPGTPLWLLVLLLI 301
|
....
gi 227351252 315 LVGF 318
Cdd:cd17475 302 LLGL 305
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
29-397 |
4.29e-10 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 61.05 E-value: 4.29e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 29 ALPQIKSALNVSQPQVEYLVTAPSFAVMFFVVLSPLLQDWFniSDKHIIMAGITIVGIAGLIPSFVSNYMVILISRLFLG 108
Cdd:cd17319 25 AAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRF--GARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 109 AGYGLYNSQAISLISVWYQDHERTSMQGWRSAFEQIGNACTLTISSLLLIYAGWHAAFLVYGLAFAVMAFFAWRVpndah 188
Cdd:cd17319 103 VAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFY----- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 189 sntttsdnqqatetispitnepvtkiSPLVIAILAFVLLIKMDFIGMEDRFPGLAVAINGKTFTGTGTYLSLMLIGATLG 268
Cdd:cd17319 178 --------------------------LRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 269 GACYGVLQKHFGYV---GTIYIGLILLAIANFLFGFGGNSFPIIAAgILLVGFPMQVLTPLIFNILPFMAPMKLQTKVTS 345
Cdd:cd17319 232 MILGGRLSDRLLRGarrLVIIIGLLLAAVGLLLAYLTTSPVVAVIL-LSLAGFGIGAASPVFWSLPADLLPGEAAATAGG 310
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 227351252 346 FVLIGFNFGAFFSPTADAWFNHLLSqplnglGLAAPFRIYGVMMLIIAGLLF 397
Cdd:cd17319 311 LINSGGNLGGFVAPLLIGYLVDATG------SYTAAFLFLAAVALLAALLVL 356
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
77-398 |
2.22e-09 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 58.78 E-value: 2.22e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 77 IMAGITIVGIAGLIPSFVSNYMVILISRLFLGAGYGLYNSQAISLISVWYQDHERTSMQGWRSAFEQIGNACTLTISSLL 156
Cdd:cd06173 72 LLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLL 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 157 LIYAGWHAAFLVYGLAFAVMAFFAWRVPNDAHSNTTTSDNQQATETISPITnepVTKISPLVIAILAFVLLIKMDFIGME 236
Cdd:cd06173 152 VALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLR---YLRRSPLLRLLLLALALFALLGGALT 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 237 DRFPGLAVAINGKTFTGTGTYLSLMLIGATLGGACYGVLQKHFGYVGTIYIGLILLAIANFLFGFgGNSFPIIAAGILLV 316
Cdd:cd06173 229 VLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGL-SPSLWLLLAALFLL 307
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 317 GFPMQVLTPLIFNILPFMAPMKLQTKVTSFVLIGFNFGAFFSPTADAWFnhllsqpLNGLGLAAPFRIYGVMMLIIAGLL 396
Cdd:cd06173 308 GLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLL-------ADALGLSAVFLLAGALLLLAALLL 380
|
..
gi 227351252 397 FM 398
Cdd:cd06173 381 LL 382
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
11-329 |
4.16e-09 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 57.97 E-value: 4.16e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 11 LAFLSAsFMVTSAYAIQSALPQIKSALNVSQPQVEYLVTApsfavmFFVVLSPLLQDWFNISD----KHIIMAGITIVGI 86
Cdd:cd17320 4 LALLVA-LGPLAIDMYLPALPAIARDLGASASAVQLTLSA------YLLGFALGQLLYGPLSDrfgrRPVLLAGLLLFIL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 87 AGLIPSFVSNYMVILISRLF--LGAGYGLYNSQAIslISVWYQDHERTSMQGWRSAFEQIGNACTLTISSLLLIYAGWHA 164
Cdd:cd17320 77 ASLLCALASSIEQLLIARFLqgLGAAAGSVVARAI--VRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 165 AFLV-YGLAFAVMAFFAWRVPNDAHSNTTTSDNQQATETISPITNEPVTKISPLVIAILAFVLLIkmdFIGMEdrfPGLA 243
Cdd:cd17320 155 IFVFlALLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFA---YLAAA---PFIY 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 244 VAINGKTFTGTGTYLSLMLIGATLGGACYGVLQKHFGYVGTIYIGLILLAIANFLF----GFGGNSFPIIAAGILLVGFP 319
Cdd:cd17320 229 IEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLllaaLLGGLSLWPLVAPLFLIFFG 308
|
330
....*....|
gi 227351252 320 MQVLTPLIFN 329
Cdd:cd17320 309 FGLIFPNATS 318
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
29-184 |
1.43e-08 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 55.59 E-value: 1.43e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 29 ALPQIKSALNVSQPQVEYLVTAPSFAVMFFVVLSPLLQDWFniSDKHIIMAGITIVGIAGLIPSFVSNYMVILISRLFLG 108
Cdd:COG0477 36 ALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRY--GRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQG 113
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 227351252 109 AGYGLYNSQAISLISVWYQDHERTSMQGWRSAFEQIGNACTLTISSLLLIYAGWHAAFLVYGLAFAVMAFFAWRVP 184
Cdd:COG0477 114 IGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRLP 189
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
11-399 |
2.00e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 55.66 E-value: 2.00e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 11 LAFLSASFMVTSAYAIQsALPQIKSALNVSQPQVEYLVTAPSFAVMFFVVLSPLLQDWFniSDKHIIMAGITIVGIAGLI 90
Cdd:cd17504 1 LALAALAVMLVETMLSP-ALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLY--GRKKVLLIVLAIYTAGSLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 91 PSFVSNYMVILISRLFLGAGYGLyNSQAISLISVWYQDHERTSMQGWRSAFEQIGNACTLTISSLLLIYAGWHAAFLVYG 170
Cdd:cd17504 78 AAFAPNLPVLIAGRALQGIGGAV-FPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 171 LAFAVMAFFAWRVPNDAHSNTTTSdnqqatetispitnepVTKISPLVIAILAFVLLIKMDFIGMEDRFPGLavainGKT 250
Cdd:cd17504 157 PVAVLLAALVPLIDLRLLRRRNVL----------------LANITALLAGFGMFMVFQLLPQLLQLPTPTGF-----GLG 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 251 FTGTGTYLSLMLIGATLGGACYGVLQKHFGYVGTIYIGLILLAIANFLFGFGGNSFPIIAAGILLVGFPMQVLTPLIFNI 330
Cdd:cd17504 216 ITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNI 295
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 227351252 331 LPFMAPMKLQTKVTSFVLIGFNFGAFFSPTADAWFNHLLSQPLNGLGLAAPfRIYGVMMLIIAGLLFMG 399
Cdd:cd17504 296 VVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYTVSITSGGVPTE-GAYVLAFLIGAALALAA 363
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
11-361 |
3.79e-08 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 54.95 E-value: 3.79e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 11 LAFLS--ASFMVTSAYAIqsALPQIKSALNVSQPQVEYLVTAPSFAVMFFVVLSPLLQDWFNISDKHIIMAGITIVGIAG 88
Cdd:cd17341 3 LSWLSffLGFMVWFLFAP--LGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 89 LIpSFVSNYMVILISRLFLGAGYGLYNSqAISLISVWYQDHERTSMQGWRSAFEQIGNACT-------LTISSLLLIYAG 161
Cdd:cd17341 81 LA-LAVSSYWGLLVLGFLLGFAGANFAS-GQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSqllapliAGAIVFDGGFVG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 162 WHAAFLVYGLAFAVMAFFAWRVPNDAhsNTTTSDNQQATETISPITNEPVTkisplviAILAFVLLIKMD-FIGMEDRFP 240
Cdd:cd17341 159 WRNAFFVPGILLAIAAVLVLLFGDDL--PTGKASALEFLKVQLAVLKNYRT-------WILSLLYGVTFGsFVGFSNVLP 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 241 GLAVAINGKTFTGTGTYLSLMLIGATLGGACYGVLQKHFGYVGTIYIGLILLAIANFLFGFGGNSFPIIAAGILLVGFPM 320
Cdd:cd17341 230 TYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFVAL 309
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 227351252 321 QVLTPLIFNILPFMAPMKLQTK---VTSFVLIGFNFGAFFSPTA 361
Cdd:cd17341 310 GLGAGAGNGSVFRMVPFIFRRElgaVTGLVGAIGGLGGFFLPLL 353
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
24-190 |
8.31e-08 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 54.16 E-value: 8.31e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 24 YAIQSALPQIKSALNVSQPQVEYLVTApsFAVmFFVVLSPL---LQDWFNisDKHIIMAGITIVGIAGLIPSFVSNYMVI 100
Cdd:cd17328 16 FTIAGVLPDIQSDFLIDDSLAGLLQTV--FII-SYMVLSPIfgyLGDRYN--RKWILAVGILIWSAATLLSSFAPNFWQL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 101 LISRLFLGAGYGLYNSQAISLISVWYQDHERTSMQGWRSAFEQIGNACTLTISSLLLIYA-GWHAAFLVYGLAFAVMAFF 179
Cdd:cd17328 91 LLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVLGVLLAIL 170
|
170
....*....|.
gi 227351252 180 AWRVPNDAHSN 190
Cdd:cd17328 171 LLLFVREPPRG 181
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
28-320 |
1.17e-07 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 53.35 E-value: 1.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 28 SALPQIKSALNVSQPQVEYLVTAPSFAVMFFVVLSPLLQDWFniSDKHIIMAGITIVGIAGLIPSFVSNYMVILISRLFL 107
Cdd:cd17503 17 VALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRF--GTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQ 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 108 GAGYGLYNSQAISLISVWYQDHERTSMQGWRSAFEQIGNACTLTISSLLLIYAGWHAAFLVyGLAFAVMAFfawrvpnda 187
Cdd:cd17503 95 GFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYI-NLPIGILAL--------- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 188 hsntttsdnqqateTISPITNEPVTKISPLVIAILAfVLLIKMDFIGMEDRFPGLAVAINGKTFTGTGTYLSLMLIGATL 267
Cdd:cd17503 165 --------------LLAPLLDLRLFKDRNFTLGLLL-SFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAI 229
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 227351252 268 GGACYGVLQKHFGYVGTIYIGLILLAIANFLFGFGGN--SFPIIAAGILLVGFPM 320
Cdd:cd17503 230 LSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPdtSLWLIILPLFIRGLGM 284
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
14-315 |
2.26e-07 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 52.60 E-value: 2.26e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 14 LSASFMV-TSAYAIQSALPQIKSALNVSQPQVEYLVTAPSFAVMFFVVLSPLLQDWFniSDKHIIMAGITIVGIAGLIPS 92
Cdd:cd17489 2 LLANFFFfLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRF--GRKRLLLIGLLIFALATLLYL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 93 FVSNYMVILISRLFLGAGYGLYnSQAISLISVWYQDHERTS-MQGWRSAFEQIGNACTLTISSLLLIYAGWHAAFLVYGL 171
Cdd:cd17489 80 LATSVALLLVLRLIHGIGWGAF-TTAAATLVADIIPPSRRGeGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 172 AFAVMAFFAWRVPNDAHSNTTTSdnqqatetiSPITNEPVTKISPLVIAILAFVLLIKMDFiGMEDRFpgLAVAINGKTF 251
Cdd:cd17489 159 LALLALLLVFLVKDPPPVAAEEA---------EAGTRAFRRLVEKKVLPPALILFLASIAY-GAISTF--LPLYAAERGI 226
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 227351252 252 TGTGTYLSLMLIGATLGGACYGVLQKHFGYVGTIYIGLILLAIANFLFGFGGNSFPIIAAGILL 315
Cdd:cd17489 227 SNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLY 290
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
7-184 |
2.56e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 52.18 E-value: 2.56e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 7 LATKLAFLSASFMVTSAYAIQSALPQI-KSALNVSQPQVEYLVTAPSFAVMFFVVLSPLLQDWFNISDKHIIMAGITIVG 85
Cdd:COG2271 180 LRFWLLALAYFLVYFALYGFLTWLPTYlVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 86 IAGLIPSFVSNYMVILISRLFLGAGYGLYNSQAISLISVWYQDHERTSMQGWRSAFEQIGNACTLTISSLLLIYAGWHAA 165
Cdd:COG2271 260 LALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAA 339
|
170
....*....|....*....
gi 227351252 166 FLVYGLAFAVMAFFAWRVP 184
Cdd:COG2271 340 FLLLAALALLAALLALLLL 358
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
30-327 |
7.93e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 50.63 E-value: 7.93e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 30 LPQIKSALNVSQPQVeylvtapSFAVMFFVVLSPLLQDWFN-ISDKH----IIMAGITIVGIAGLIPSFVSNYMVILISR 104
Cdd:cd17478 19 LPLLIAKLGLSYAQA-------GLLVSVFSITSSLLQPLFGyLADRKprryLLPLGPLLTGLGLSLLGFAPNYWLLLLLV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 105 LFLGAGYGLYNSQAISLISVwYQDHERTSMQGWRSAFEQIGNACTLTISSLLLIYAGWHAAFLVYGLAFAVMAFFAWRVP 184
Cdd:cd17478 92 ALAGIGSAAFHPEGARLASQ-AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLR 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 185 NDAHsntttsdNQQATETISPITNEPVTKISPLVIAILAFVLLIKMDFIGMEDRFPGLAVAINGKTFTGtGTYLSLMLIG 264
Cdd:cd17478 171 PLKK-------PEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFA-GLLLSLFLFA 242
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 227351252 265 ATLGGACYGVLQKHFGYVGTIYIGLILLAIANFLFGFggNSFPIIAAGILLVGFPMQVLTPLI 327
Cdd:cd17478 243 GAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLL--TPGIWSYILLVLAGFLLFASFPVT 303
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
30-397 |
3.32e-06 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 48.86 E-value: 3.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 30 LPQIKSALNVSQPQVEYLVTAPSFAVMFFVVLSPLLQDWFniSDKHIIMAGITIVGIAGLIPSFVSNYMVILISRLFLGA 109
Cdd:cd17333 19 GPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRL--GRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 110 GYGLYNSQAISLISVWYQDHERTSMQGWRSAFEQIGNACTLTISSLLLIYAGWHAAFLVYGL---AFAVMAFFAWRVPND 186
Cdd:cd17333 97 GAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLIIGLiylLLAILILLTLFPELP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 187 AHSNTTTSDNQQATETISPITNepvtkisplvIAILAFVLLIkMDFIGMEDRF----PGLAVAINGKTFTGTGTYLSLML 262
Cdd:cd17333 177 SARNPQQSVGAFSASASRLLRN----------PSIILGALAL-FLYVGAETAFsswvPSYLVEKKHVSDGLAGYLLSGFW 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 263 IGATLGGACYGVLQKHFGYvgTIYIGLI-LLAIANFLFGFGGNSFPIIAAGILLVGFPMQVLTPLIFNILPFMAPmKLQT 341
Cdd:cd17333 246 VGITIGRLLGGPISRRIKP--HTLLVLSgSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLP-YAKG 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 227351252 342 KVTSFVLIGFNFGAFFSPTADAWFnhllsqpLNGLGLAAPFRIYGVMMLIIAGLLF 397
Cdd:cd17333 323 KGTSVLLAAGSIGGAIIPFIMGFI-------AEAVGIQTAMLLITILYAIIFVLAL 371
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
74-183 |
3.98e-06 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 48.70 E-value: 3.98e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 74 KHIIMAGITIVGIAGLI-PSFVSNYMVILI-SRLFLGAGYGLYNSQAISLISVWYQDHERTSMQGWRSAFEQIGNACTLT 151
Cdd:cd17380 64 KKVLLLAVALWSLATLLtPLLAYSSLPLLIlSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGL 143
|
90 100 110
....*....|....*....|....*....|..
gi 227351252 152 ISSLLLIYAGWHAAFLVYGLAFAVMAFFAWRV 183
Cdd:cd17380 144 IGPLLLEYYGWPSVFYFFGLLGLLWALVWLIY 175
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
11-391 |
4.17e-06 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 48.76 E-value: 4.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 11 LAFLSASFMVTSAYAIQSALPQIKSALNVSQPQVEYLVTAPSFAVMFFVVLSPLLQDwfNISDKHIIMAGITIVGIAGLI 90
Cdd:cd17353 7 LGAVLMHLILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVD--RGGPRKAILIGGILFGLGFIL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 91 PSFVSNYMVILISRLFL-GAGYGLYNSQAISLISVWYQDHertsmQGWRSAFEQIGNAC----TLTISSLLLIYAGWHAA 165
Cdd:cd17353 85 SAFAISLPLLFLGYGVLgGIGAGIGYITPVSTAVKWFPDK-----RGLATGIVIAGFGLgsliFSPLIAYLINTVGVPTT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 166 FLVYGLAFAVMAFFA---WRVPNDAHSNTTTSDNQQATE------TISPITNEPVTKISPLVIAILAFVLLIkmdFIGMe 236
Cdd:cd17353 160 FLILGIIFLIIIVIGaflIRDPPKGWVPPGVDPLANNAEnsprdyTPREMLRTPTFWLLWLMFFLNATAGLM---LIGQ- 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 237 drFPGLAVAINGKTFTGTGTYLSLMLIGATLGGACYGVLQKHFGYVGTIYIGLILLAIANFLFGFGGNSFPIIAAGILLV 316
Cdd:cd17353 236 --AKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALI 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 227351252 317 GFPMQVLTPLIFNILPFMAPMKLQTKVTSFVLIGFNFGAFFSPTADAWFnhllsqpLNGLGLAAPFRIYGVMMLI 391
Cdd:cd17353 314 GFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYV-------LYTGGYNAAFIIAAALSLV 381
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
11-181 |
7.01e-06 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 47.65 E-value: 7.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 11 LAFLSASFMVTSAYAIQSALPQIKSALNVSQPQVEYLVTAPSFAVMFFVVLSPLLQDWFNIsdKHIIMAGITIVGIAGLI 90
Cdd:cd17312 7 GVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNI--RRFMSAGLLLSALANIF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 91 PSFVSNYMVILISRLFLGAGYGLYNSQAISLISVWYQDHERTSMQGWRSAFEQIGNACTLTISSLLLIYAGWHAAFLVYG 170
Cdd:cd17312 85 MGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPG 164
|
170
....*....|.
gi 227351252 171 LAFAVMAFFAW 181
Cdd:cd17312 165 IVGLVVAIILF 175
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
14-181 |
9.93e-06 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 47.26 E-value: 9.93e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 14 LSASFMVTSAYAIQ-SALPQIKSALNVSQPQVEYLVTAPSFAVMFFVVLSPLLQDWFniSDKHIIMAGITIVGIAGLIPS 92
Cdd:cd17476 4 SGAQLLNQAGLGSViVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIY--GHKKMFVIGSFWFAIWSLIAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 93 FVSNYMVILISRLFLGAGYGLYNSQAISLISVWYQDHERTSMQ-GWRSAFEQIGNACTLTISSLLLIYAGWHAAFLVYGL 171
Cdd:cd17476 82 FSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPRKNIVfSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAI 161
|
170
....*....|
gi 227351252 172 AFAVMAFFAW 181
Cdd:cd17476 162 LAAIVAVAAI 171
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
74-396 |
1.49e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 46.83 E-value: 1.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 74 KHIIMAGITIVGIAGLIPSFVSNYMVILISRLFLGAGYGLYNSQAISLISVWYQDHERTSMQGWRSAFEQIGNACTLTIS 153
Cdd:cd17316 66 KKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVA 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 154 SLLLIYA----GWHAAFLVyGLAFAVMAFFAWRvpndahsntttsdnqqatetispitnepvtkispLVIAILAFVLLIK 229
Cdd:cd17316 146 SLLIPLLsgdwGWRILFLI-GALPALLALLLRR----------------------------------RTLLLILLWFFIS 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 230 MDFIGMEDRFPGLAVAINGKTFTGTGTYLSLMLIGATLGGACYGVLQKHFGYVGTIYIGLILLAIANFLFGF-GGNSFPI 308
Cdd:cd17316 191 FGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYlLSGSPTL 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 309 IAAGILLVGFPMQVLTPLIFNILPFMAPMKLQTKVTSFVLIGFNFGAFFSPTadawfnhLLSQPLNGLGLAAPFRIYGVM 388
Cdd:cd17316 271 LLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPP-------LIALLLASTGGTGVPALILAL 343
|
....*...
gi 227351252 389 MLIIAGLL 396
Cdd:cd17316 344 LAIVALIV 351
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
29-318 |
1.78e-05 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 46.58 E-value: 1.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 29 ALPQIKSALNVSQPQVEYLVTAPSFAVMFFVVLSPLLQDwfNISDKHIIMAGITIVGIAGLIPSFVSNYMVILISRLFLG 108
Cdd:TIGR00895 39 AAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLAD--RIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAG 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 109 AGYGLYNSQAISLISVWYQDHERTSMQGWRSAFEQIGNACTLTISSLLLIYAGWHAAFLVYGLAFAVMAFFAWRV----- 183
Cdd:TIGR00895 117 LGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFlpesi 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 184 ------------------------PNDAHSNTTTSDNQQATETISPITNEPVTKISPLVIAILAFVLLIkmdFIGMEDRF 239
Cdd:TIGR00895 197 dflvskrpetvrrivnaiapqmqaEAQSALPEQKSTQGTKRSVFKALFQGKTARITVLLWLLYFMLLVG---VYFLTNWL 273
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 227351252 240 PGLAVAInGKTFTGTGTYLSLMLIGATLGGACYGVLQKHFGyVGTIYIGLILLAIANFLFGFGGNSFPIIAAGILLVGF 318
Cdd:TIGR00895 274 PKLMVEL-GFSLSLAATGGALFNFGGVIGSIIFGWLADRLG-PRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGF 350
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
248-398 |
7.06e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 44.58 E-value: 7.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 248 GKTFTGTGTYLSLMLIGATLGGACYGVLQKHFGYVGTIYIGLILLAIANFLFGFGgNSFPIIAAGILLVGFPMQVLTPLI 327
Cdd:COG2814 41 GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALA-PSLWLLLAARFLQGLGAGALFPAA 119
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 227351252 328 FNILPFMAPMKLQTKVTSFVLIGFNFGAFFSPTADAWFNHLlsqplngLGLAAPFRIYGVMMLIIAGLLFM 398
Cdd:COG2814 120 LALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL-------FGWRWVFLVNAVLALLALLLLLR 183
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
52-398 |
1.60e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 43.34 E-value: 1.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 52 SFAVMFFVVlSPLlqdWFNISDKH----IIMAGITIVGIAGLIPSFVSNYMVILISRLFLGAGYGlYNSQAISLISVWYQ 127
Cdd:cd17330 42 SYSLGQFLA-SPL---WGRLSDRYgrkpVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGG-NVSVAQAYIADITD 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 128 DHERTSMQGWRSAFEQIGNACTLTISSLLLIYAGWHAAFLVYGLAFAVMAFFAWRVPndahsntttsdnqqatetispit 207
Cdd:cd17330 117 EEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFL----------------------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 208 nepvtkisPLVIAILAFVLLIKMDFIGMEDRFPGLAVAINGKTFTGTGTYLSLM-LIGATLGGACYGVLQKHFGYVGTIY 286
Cdd:cd17330 174 --------PPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVgIAGILAQLLLIPRLAKRLGERKLLR 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 287 IGLILLAIANFLFGFgGNSFPIIAAGILLVGFPMQVLTPLIFNILPFMAPMKLQTKVTSFVLIGFNFGAFFSPtadAWFN 366
Cdd:cd17330 246 LGLLLAIIGLLLLPF-ASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGP---LLAG 321
|
330 340 350
....*....|....*....|....*....|..
gi 227351252 367 HLLSQPLNGlglaAPFRIYGVMMLIIAGLLFM 398
Cdd:cd17330 322 PLYSFLGPG----VPFLLAAGLLLIALFLLSL 349
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
239-398 |
1.60e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 43.56 E-value: 1.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 239 FPGLAVAINGKTFTGTGTYLSLMLIGATLGGACYGVLQKHFGYVGTIYIGLILLAIANFLFGFGGNSFPIIAAGILLvGF 318
Cdd:pfam07690 19 LPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQ-GL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 319 PMQVLTPLIFNILPFMAPMKLQTKVTSFVLIGFNFGAFFSPTADAWFNHLlsqplngLGLAAPFRIYGVMMLIIAGLLFM 398
Cdd:pfam07690 98 GAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASL-------FGWRAAFLILAILSLLAAVLLLL 170
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
12-398 |
1.59e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 40.33 E-value: 1.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 12 AFLSASFMVTSAYAIQSALPQIKSALNVSQPQVeylVTAPSFAVMFFVVLSPLLQDWFNISDKHIIMAGITIVGIAGLIP 91
Cdd:cd17355 8 TFLILILSWGIRYYFGVFIIPIIAEFGWSRAVI---SLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 92 SFVSN--YMVILISRLFLGAGYGLYNSQAISLISVWYQDHERTSMQGWRSAFEQIGNACTLTISSLLLIYAGWHAAFLVY 169
Cdd:cd17355 85 LALATslWQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 170 GLAFAVMAFFAW-----RVPNDAHSNTTTSDNQQATETISPITNEPVTKISPLVIAILAFVLlikmdfIGMEDRFPGLAV 244
Cdd:cd17355 165 ALLALLVLVPVLlllrrRPADLALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAV------VGLIVHLVPYLA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 245 AINGKTFTGTGTyLSLMLIGATLGGACYGVLQKHFGYVGTIYIGLILLAIANFLFGFGGNSFPIIAAGILLVGFPMQVLT 324
Cdd:cd17355 239 DRGISPAAAAVA-LALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATV 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 227351252 325 PLIFNILPFMAPMKLQTKVTSFVLIGFNFGAFFSPTADAWFNHLLSqplnglGLAAPFRIYGVMMLIIAGLLFM 398
Cdd:cd17355 318 PLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTG------SYTAAWALAVALGLIAALLVLP 385
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
129-333 |
2.17e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 40.28 E-value: 2.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 129 HERTSMQGWRSAFEQIGNACTLTISSLLLIY-------AGWHAAFLVYGLAFAVMAFFAWrvpndahsNTTTsdnQQATE 201
Cdd:cd17332 132 EERTSLTSWRMFFATIGGLLVTVLPPPLVAYfgggnasRGYFLTALIIGIIGIILLLICF--------FGTR---ERVVP 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 202 TISPITNEPVTKISPLVIAILAFVLLIKMDFIGMedrfpgLAVAINGKTFT-----------GTGTYLSLMLIGATLGGA 270
Cdd:cd17332 201 PEEEKSKLPLLKSLKALLKNRPFLILLLAYLLYF------LAFNIVNTVLVyyfkyvlggraELVLLLLLILSGALLALL 274
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 227351252 271 CYGVLQKHFGYVGTIYIGLILLAIANFLFGF-GGNSFPIIAAGILLVGFPMQVLTPLIFNILPF 333
Cdd:cd17332 275 PWPPLKKRFGKKKAFFIGLLLAILGLLLLFFlPPGNLVLILVLAVLAGIGYGGANLLPWAMLAD 338
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
11-147 |
2.61e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 39.57 E-value: 2.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 11 LAFLSASFMVTSAYAIQSALPQI-KSALNVSQPQVEYLVTAPSFAVMFFVVLSPLLQDWFniSDKHIIMAGITIVGIAGL 89
Cdd:COG2814 211 LLLLLAFLLGFGFFALFTYLPLYlQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF--GRRRLLLIGLLLLALGLL 288
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 227351252 90 IPSFVSNYMVILISRLFLGAGYGLYNSQAISLISVWYQDHERTSMQGWRSAFEQIGNA 147
Cdd:COG2814 289 LLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGP 346
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
250-399 |
2.88e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 39.47 E-value: 2.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 250 TFTGTGTYLSLMLIGATLGGACYGVLQKHFGYVGTIYIGLILLAIANFLFGFGGnSFPIIAAGILLVGFPMQVLTPLIFN 329
Cdd:COG2271 43 SAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFAT-SFWQLLLLRFLLGLGEAGFFPAALK 121
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 330 ILPFMAPMKLQTKVTSFVLIGFNFGAFFSPTADAWFnhllsqpLNGLGLAAPFRIYGVMMLIIAGLLFMG 399
Cdd:COG2271 122 LIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWL-------LAAFGWRAAFLILGLPGLLLALLRFWL 184
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
250-399 |
3.79e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 39.09 E-value: 3.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 250 TFTGTGTYLSLMLIGATLGGACYGVLQKHFGYVGTIYIGLILLAIANFLFGFGgNSFPIIAAGILLVGFPMQVLTPLIFN 329
Cdd:COG2223 38 SAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALA-VSYWLLLLLGLLLGIGGGGSFAVGIA 116
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 330 ILPFMAPMKLQTKVTSFVLIGFNFGAFFSPTADAWFnhllsqpLNGLGLAAPFRIYGVMMLIIAGLLFMG 399
Cdd:COG2223 117 LVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLL-------IAAFGWRNAFLILGILLLVVAVLAWLF 179
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
11-184 |
4.14e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 39.09 E-value: 4.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 11 LAFLSASFMVTSAYAIQSALPQI-KSALNVSQPQVEYLVTAPSFAVMFFVVLSPLLQDWFNISDKHIIMAGITIVGIAGL 89
Cdd:COG2223 209 LLSLLYFGTFGSFIGFSSWLPPYlVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLL 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 90 iPSFVSNYMVILISRLFLGAGYGLYNSQAISLISVWYQDHERTSMQGWRSAFEQIGNACT-LTISSLLLIYAGWHAAFLV 168
Cdd:COG2223 289 -ALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGpLLFGALLDATGSYTAAFLV 367
|
170
....*....|....*.
gi 227351252 169 YGLAFAVMAFFAWRVP 184
Cdd:COG2223 368 FAVLALVALVLTLLLY 383
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
25-318 |
5.19e-03 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 38.72 E-value: 5.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 25 AIQSALPQIKSALNVSQPQVEYLVTAPSFAVMFFVVLSPLLQDWFNIsdKHIIMAGITIVGIAGLIPSFVSNYMVILISR 104
Cdd:cd17365 17 VMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGR--KRVLLVSVALFGLFTLLTAFAQSVLQLALLR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 105 LFLGAGYGLYNSQAISLISVWYQDHERTSMQGWRSAFEQIGNACTLTISSLLLIYAGWHAAFLVYGLAFAVMAFFAWrvp 184
Cdd:cd17365 95 FLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLLR--- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 185 ndahsntttsdnqqatetispitnepvtkiSPLVIAILAFVLLIKmdFIGMEDRFPGLAVAiNGKTFTGTGTYLSLMLIG 264
Cdd:cd17365 172 ------------------------------GTLLLWVTFFMGLLL--VYLLNSWLPKLMVE-AGYSLSQALTITLLLNIG 218
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 227351252 265 ATLGGACYGVLQKHFGYVGTIYIGLILLAIANFLFGFGGNSFPIIAAGILLVGF 318
Cdd:cd17365 219 GVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPASLVLLYVLVFLAGA 272
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
1-183 |
6.97e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 38.32 E-value: 6.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 1 MKQSQSLATKLAFLSASFMVTSAY-AIQSALPQI-KSALNVSQPQVEYLVTAPSFAVMFF-VVLSPLLQDWFniSDKHII 77
Cdd:cd17474 191 LKKALRGRGLLTFLVSAFLYFFLYfAFLTYLPFLlELLYGISPIIIGLLFAGWSVLLALGsLFVGRLLKKRF--GARRIL 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 78 MAGITIVGIAGLIPSFVSNYMVILISRLFLGAGYGLYNSQAISLISVWYQDHERTSMQGWRSAFEQIGNACTLTISSLLL 157
Cdd:cd17474 269 VIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLL 348
|
170 180
....*....|....*....|....*.
gi 227351252 158 IYAGWHAAFLVYGLAFAVMAFFAWRV 183
Cdd:cd17474 349 EIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
81-396 |
7.96e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 38.44 E-value: 7.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 81 ITIVG--IAGLIPSFVSNYMVILISRLFLGAGYGLYNSQAISLISVWYQDHERTSMQGWRSAFEQIGNACTLTISSLLLI 158
Cdd:cd17371 69 ITILLfaVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFP 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 159 YA----GWHAAFLVYGLAFAVMAFFAWRVPNDA------HSNTTTsdnqQATETISPITNEPVTKISPLVIAILAFVLLI 228
Cdd:cd17371 149 LLppeiAWRVLFLLGALPALLVLFIRRFVKEPPqwqaarAARRHF----ADRPSLRELFSPPLLRTTLLASLLATGALGG 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 229 kmdFIGMEDRFPGLAVAINGKTFTGTGTYLSLMLIGATLGGACYGVLQKHFGYVGTIYIGLILLAIANFLFGFGGNSFPI 308
Cdd:cd17371 225 ---YYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLSPTL 301
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 309 IAAGILLVGFPMQVLTPLIFNILPFMAPMKLQTKVTSFVLIGFNFGAFFSPTADAWfnhLLSQPLNGLGLAAPFRIYGVM 388
Cdd:cd17371 302 ILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGF---LATSGSLGTAIAVFAAVYYIA 378
|
....*...
gi 227351252 389 MLIIAGLL 396
Cdd:cd17371 379 GLVLALLL 386
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
74-355 |
8.26e-03 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 37.93 E-value: 8.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 74 KHIIMAGITIVGIAGLIPSFVSNYMVILISRLFLGAGYGLYNSQAISLISVWYQDHERTSMQGWRSAFEQIGNACTLTIS 153
Cdd:cd17502 60 KWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIG 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 154 SLLLIYAGWHAAFLVyGLAFAVMAFFawrvpndahsntttsdnqqatetispitnepvtkISPLVIAILAFVLLIKMDFI 233
Cdd:cd17502 140 GAFTDHLSWRWCFYI-NLPIGGLALA----------------------------------LLRTILLSSIFGFLFGGALF 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227351252 234 GMEDRFPGLAVAINGKTFTGTGTYLSLMLIGATLGGACYG-VLQKHFGYVGTIYIGLILLAIANFLFGF--GGNSFPIIA 310
Cdd:cd17502 185 GLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGaLISKTGRYKPLIVIGTILMSVGAGLLTTltLDTSKWLLI 264
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 227351252 311 AGILLVGFPMQVLTPLIFNILPFMAPMKLQTKVTSFVLIGFNFGA 355
Cdd:cd17502 265 GYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGG 309
|
|
| |
