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Conserved domains on  [gi|228822341|gb|EEM68321|]
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D-Ala-D-Ala carboxypeptidase A; Serine peptidase; MEROPS family S11 [Bacillus thuringiensis serovar berliner ATCC 10792]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
strep_PBP3 super family cl45725
streptococcal D-alanyl-D-alanine carboxypeptidase PBP3; PBP3 (penicillin-binding protein 3) is ...
 4-388 1.82e-120

streptococcal D-alanyl-D-alanine carboxypeptidase PBP3; PBP3 (penicillin-binding protein 3) is the lone D-alanyl-D-alanine carboxypeptidase in Streptococcus pneumoniae. The gene is known as pbp3 or dacA.


The actual alignment was detected with superfamily member NF038273:

Pssm-ID: 468443 [Multi-domain]  Cd Length: 407  Bit Score: 355.72  E-value: 1.82e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341   4 SNASAEtgaALNIEAGAAILVEANSGKILYQKNADELLSIASMTKMMSEYLVHEAVDKGKLKWDQKIKVSEYAYKVSQDA 83
Cdd:NF038273  17 TTVSAD---DFDVAAKHAIAVEANTGKILYEKDATTPVPIASLTKLLTAYLVYKEIKSGKLSWDTPVKISDYPYELTTNY 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341  84 SLSNVALENGgSYTVKELYEAMAIFSANGATIALAEAIAGKEVDFVKMMNDKSKELGLKNYKFVNSTGLTNKDLKGMHPE 163
Cdd:NF038273  94 EISNVPLDAR-KYTVKELLEASLVASANSAAIALAEKIAGSEPKFVDKMKAQLKEWGITDAKLVNASGLNNSYLGDHIYP 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341 164 GTTADEENKMSAKDVATLAQHLIKDYPKVLDTAKIPKKEFRPEKekfaMSNWNWMLKGLVKEYDGVDGLKTGSTPEAGDC 243
Cdd:NF038273 173 GSKKDDENKLSAKDVAIIARHLIKDFPEVLKITSKTSADFAGTT----IYSYNYMLKGMPYYREGVDGLKTGTTEKAGAS 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341 244 FTGTVERNGMRFISVVIKT----SSHTARFDETKKLYDYGFANFEVKQMYKKGSSVKgQETVRVENAKDKDVAVQTKQAI 319
Cdd:NF038273 249 FVATSVENGMRVITVVLNAdnadEDEYARFTATNQLLDYIYQNFEKVTLVKKGQAYK-DSKLPVIDGKKKTVSAVAKKDL 327

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 228822341 320 SLPVPKGSKDVYKTELKESSKGQEAPIKKGAALGQmvITPKDTND--PGFLtGKSLQVDLVTTSEVEEANW 388
Cdd:NF038273 328 TVIQKIGTDSKPSVKFTPKKKELTAPIKKGQVVGK--ATFKDKDLigKGYL-GEPPSVELVAKKDVKKSFF 395
 
Name Accession Description Interval E-value
strep_PBP3 NF038273
streptococcal D-alanyl-D-alanine carboxypeptidase PBP3; PBP3 (penicillin-binding protein 3) is ...
 4-388 1.82e-120

streptococcal D-alanyl-D-alanine carboxypeptidase PBP3; PBP3 (penicillin-binding protein 3) is the lone D-alanyl-D-alanine carboxypeptidase in Streptococcus pneumoniae. The gene is known as pbp3 or dacA.


Pssm-ID: 468443 [Multi-domain]  Cd Length: 407  Bit Score: 355.72  E-value: 1.82e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341   4 SNASAEtgaALNIEAGAAILVEANSGKILYQKNADELLSIASMTKMMSEYLVHEAVDKGKLKWDQKIKVSEYAYKVSQDA 83
Cdd:NF038273  17 TTVSAD---DFDVAAKHAIAVEANTGKILYEKDATTPVPIASLTKLLTAYLVYKEIKSGKLSWDTPVKISDYPYELTTNY 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341  84 SLSNVALENGgSYTVKELYEAMAIFSANGATIALAEAIAGKEVDFVKMMNDKSKELGLKNYKFVNSTGLTNKDLKGMHPE 163
Cdd:NF038273  94 EISNVPLDAR-KYTVKELLEASLVASANSAAIALAEKIAGSEPKFVDKMKAQLKEWGITDAKLVNASGLNNSYLGDHIYP 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341 164 GTTADEENKMSAKDVATLAQHLIKDYPKVLDTAKIPKKEFRPEKekfaMSNWNWMLKGLVKEYDGVDGLKTGSTPEAGDC 243
Cdd:NF038273 173 GSKKDDENKLSAKDVAIIARHLIKDFPEVLKITSKTSADFAGTT----IYSYNYMLKGMPYYREGVDGLKTGTTEKAGAS 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341 244 FTGTVERNGMRFISVVIKT----SSHTARFDETKKLYDYGFANFEVKQMYKKGSSVKgQETVRVENAKDKDVAVQTKQAI 319
Cdd:NF038273 249 FVATSVENGMRVITVVLNAdnadEDEYARFTATNQLLDYIYQNFEKVTLVKKGQAYK-DSKLPVIDGKKKTVSAVAKKDL 327

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 228822341 320 SLPVPKGSKDVYKTELKESSKGQEAPIKKGAALGQmvITPKDTND--PGFLtGKSLQVDLVTTSEVEEANW 388
Cdd:NF038273 328 TVIQKIGTDSKPSVKFTPKKKELTAPIKKGQVVGK--ATFKDKDLigKGYL-GEPPSVELVAKKDVKKSFF 395
DacC COG1686
D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis];
6-391 7.84e-113

D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441292 [Multi-domain]  Cd Length: 324  Bit Score: 333.34  E-value: 7.84e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341   6 ASAETGAALNIEAGAAILVEANSGKILYQKNADELLSIASMTKMMSEYLVHEAVDKGKLKWDQKIKVSEYAYKVsqdaSL 85
Cdd:COG1686   16 AAAAPAAPPDIAAKSAILIDADTGQVLYEKNADERLPPASLTKLMTAYVVLEALKAGKISLDDKVTVSEEAART----GG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341  86 SNVALENGGSYTVKELYEAMAIFSANGATIALAEAIAGKEVDFVKMMNDKSKELGLKNYKFVNSTGLTnkdlkgmhpegt 165
Cdd:COG1686   92 SKMGLKPGEQVTVEDLLKGLLLQSGNDAAVALAEHIAGSEEAFVALMNAKAKELGMTNTHFVNPTGLP------------ 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341 166 taDEENKMSAKDVATLAQHLIKDYPKVLDTAKIPKKEFrPEKEKFAMSNWNWMLkglvKEYDGVDGLKTGSTPEAGDCFT 245
Cdd:COG1686  160 --DPGHYSTARDLALLARAAIKDYPEFYEIFSTKEFTF-PNGRGITLRNTNRLL----GRYPGVDGLKTGYTDAAGYCLV 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341 246 GTVERNGMRFISVVIKTSSHTARFDETKKLYDYGFanfevkqmykkgssvkgqetvrvenakdkdvavqtkqaislpvPK 325
Cdd:COG1686  233 ASAKRGGRRLIAVVLGAPSEKARFADAAKLLDYGF-------------------------------------------PK 269

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 228822341 326 GSKDVYKTELKESSKgqeAPIKKGAALGQMVITpkdtndpgfLTGKSL-QVDLVTTSEVEEANWFTR 391
Cdd:COG1686  270 GEALKAEVVLDGPLK---APVKKGQVVGTLVVT---------LDGKTIaEVPLVAAEDVEKAGFFSR 324
Peptidase_S11 pfam00768
D-alanyl-D-alanine carboxypeptidase;
12-260 2.47e-83

D-alanyl-D-alanine carboxypeptidase;


Pssm-ID: 425859 [Multi-domain]  Cd Length: 234  Bit Score: 254.62  E-value: 2.47e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341   12 AALNIEAGAAILVEANSGKILYQKNADELLSIASMTKMMSEYLVHEAVDKGKLKWDQKIKVSEYAYKVSQDASlSNVALE 91
Cdd:pfam00768   2 SAPEIAAKSAILVDYNTGKVLYEKNPDQVRPIASITKLMTAYVVLEALKAGKIKEDDMVTISEDAWATGNPGS-SNIFLK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341   92 NGGSYTVKELYEAMAIFSANGATIALAEAIAGKEVDFVKMMNDKSKELGLKNYKFVNSTGLTNkdlkgmhpegttadEEN 171
Cdd:pfam00768  81 PGSQVSVKDLLRGALVSSGNDAAVALAEHIAGSEKAFVK*MNAKAKELGLKNTRFVNPTGLDA--------------HGQ 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341  172 KMSAKDVATLAQHLIKDYPKVLDTAKIPKKEFRpekekfAMSNWNWMLKGLVKEYDG--VDGLKTGSTPEAGDCFTGTVE 249
Cdd:pfam00768 147 YSSARDMAILAKALIKDLPEELSITKEKSFTFR------GINKINQRNRNGLLWDKTwnVDGLKTGYTNEAGYCLVASAT 220

                         250
                  ....*....|.
gi 228822341  250 RNGMRFISVVI 260
Cdd:pfam00768 221 KGGMRLISVVM 231
PBP4_Staph NF038258
penicillin-binding protein PBP4; Members of this family penicillin-binding protein 4 (PBP4), ...
 29-259 1.31e-55

penicillin-binding protein PBP4; Members of this family penicillin-binding protein 4 (PBP4), as the name is used in Staphylococcus aureus and related species from the same genus. PBP4 is not essential. It has transpeptidase activity, provides low level beta-lactam resistance, and in mutant strains can contribute to high level beta-lactam resistance.


Pssm-ID: 468436 [Multi-domain]  Cd Length: 365  Bit Score: 187.49  E-value: 1.31e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341  29 GKILYQKNADELLSIASMTKMMSEYLVHEAVDKGKLKWDQKIKVSEYAYKVSQDASLSNVALENGGSYTVKELYEAMAIF 108
Cdd:NF038258  50 GQILYDYHGNKKWDPASMTKLMTMYLTLEAIKKGKLSLNDKVKITSDYEKMSTLPNLSTFPLKPGQTYTIKELLKQTALA 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341 109 SANGATIALAEAIAGKEVDFVKMMNDKSKELGLKNYKFVNSTGLTNKDLKGMHPEGTTADEENKMSAKDVATLAQHLIKD 188
Cdd:NF038258 130 SSNAAALILAEKVSGNTSKFTDRMNEKAKALGMKHTHFTNPSGADNNLLKPYAPKKYKDETKSKSTAKDMAILSQHLIKK 209

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 228822341 189 YPKVLDTAKIPkkefRPEKEKFAMSNWNWMLKGLVKEYDGVDGLKTGSTPEAGDcFTGTVERNGMRFISVV 259
Cdd:NF038258 210 HPKILKYTKLT----ADTQHGVTLYTTNLSLPGQPMSLKGTDGLKTGTSDEGYN-LALTTKRDGLRINQVI 275
PRK10001 PRK10001
serine-type D-Ala-D-Ala carboxypeptidase;
2-415 2.62e-49

serine-type D-Ala-D-Ala carboxypeptidase;


Pssm-ID: 182189 [Multi-domain]  Cd Length: 400  Bit Score: 172.10  E-value: 2.62e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341   2 PYSNASAETGAALNIEAGAAILVEANSGKILYQKNADELLSIASMTKMMSEYLVHEAVDKGKLKWDQKIKVSEYAYKVSQ 81
Cdd:PRK10001  23 PTAFAAEQTVEAPSVDARAWILMDYASGKVLAEGNADEKLDPASLTKIMTSYVVGQALKADKIKLTDMVTVGKDAWATGN 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341  82 DA--SLSNVALENGGSYTVKELYEAMAIFSANGATIALAEAIAGKEVDFVKMMNDKSKELGLKNYKFVNSTGLtnkDLKG 159
Cdd:PRK10001 103 PAlrGSSVMFLKPGDQVSVADLNKGVIIQSGNDACIALADYVAGSQESFIGLMNGYAKKLGLTNTTFQTVHGL---DAPG 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341 160 MHPegttadeenkmSAKDVATLAQHLIKDYPKVLDTAKipKKEFRPEKEKFAMSN---WNWMLKglvkeydgVDGLKTGS 236
Cdd:PRK10001 180 QFS-----------TARDMALLGKALIHDVPEEYAIHK--EKEFTFNKIRQPNRNrllWSSNLN--------VDGMKTGT 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341 237 TPEAGDCFTGTVERNGMRFISVVIKTSSHTARFDETKKLYDYGFANFEVKQMYKKGSSVKGQetvRVENAKDKDVAVQTK 316
Cdd:PRK10001 239 TAGAGYNLVASATQGDMRLISVVLGAKTDRIRFNESEKLLTWGFRFFETVTPIKPDATFVTQ---RVWFGDKSEVNLGAG 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341 317 QAISLPVPKGSKDVYKTELKESSKGQEAPIKKGAALGQMVITpkdtndpgfLTGKSL-QVDLVTTSEVEEanwftramrg 395
Cdd:PRK10001 316 EAGSVTIPRGQLKNLKASYTLTEPQLTAPLKKGQVVGTIDFQ---------LNGKSIeQRPLIVMENVEE---------- 376

                        410       420
                 ....*....|....*....|
gi 228822341 396 iGSFFSGMWNSAVDTVKGWF 415
Cdd:PRK10001 377 -GGFFSRMWDFVMMKFHQWF 395
PBP5_C smart00936
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. ...
 283-385 1.39e-16

Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. coli functions as a D-alanyl-D-alanine carboxypeptidase. It is composed of two domains that are oriented at approximately right angles to each other. The N-terminal domain (pfam00768) is the catalytic domain. The C-terminal domain featured in this family is organized into a sandwich of two anti-parallel beta-sheets, and has a relatively hydrophobic surface as compared to the N-terminal domain. Its precise function is unknown; it may mediate interactions with other cell wall-synthesising enzymes, thus allowing the protein to be recruited to areas of active cell wall synthesis. It may also function as a linker domain that positions the active site in the catalytic domain closer to the peptidoglycan layer, to allow it to interact with cell wall peptides.


Pssm-ID: 198004 [Multi-domain]  Cd Length: 92  Bit Score: 74.56  E-value: 1.39e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341   283 FEVKQMYKKGSSVKgqeTVRVENAKDKDVAVQTKQAISLPVPKGSKDVYKTELKESSKGQEAPIKKGAALGQMVITpkdt 362
Cdd:smart00936   1 FETVKLYKKGQVVG---TVKVWKGKEKTVKLGAKEDVYVTLPKGEKKKLKAKVVLDKPELEAPIKKGQVVGTLVVT---- 73

                           90       100
                   ....*....|....*....|...
gi 228822341   363 nDPGFLTGKslqVDLVTTSEVEE 385
Cdd:smart00936  74 -LDGKLIGE---VPLVALEDVEK 92
 
Name Accession Description Interval E-value
strep_PBP3 NF038273
streptococcal D-alanyl-D-alanine carboxypeptidase PBP3; PBP3 (penicillin-binding protein 3) is ...
 4-388 1.82e-120

streptococcal D-alanyl-D-alanine carboxypeptidase PBP3; PBP3 (penicillin-binding protein 3) is the lone D-alanyl-D-alanine carboxypeptidase in Streptococcus pneumoniae. The gene is known as pbp3 or dacA.


Pssm-ID: 468443 [Multi-domain]  Cd Length: 407  Bit Score: 355.72  E-value: 1.82e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341   4 SNASAEtgaALNIEAGAAILVEANSGKILYQKNADELLSIASMTKMMSEYLVHEAVDKGKLKWDQKIKVSEYAYKVSQDA 83
Cdd:NF038273  17 TTVSAD---DFDVAAKHAIAVEANTGKILYEKDATTPVPIASLTKLLTAYLVYKEIKSGKLSWDTPVKISDYPYELTTNY 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341  84 SLSNVALENGgSYTVKELYEAMAIFSANGATIALAEAIAGKEVDFVKMMNDKSKELGLKNYKFVNSTGLTNKDLKGMHPE 163
Cdd:NF038273  94 EISNVPLDAR-KYTVKELLEASLVASANSAAIALAEKIAGSEPKFVDKMKAQLKEWGITDAKLVNASGLNNSYLGDHIYP 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341 164 GTTADEENKMSAKDVATLAQHLIKDYPKVLDTAKIPKKEFRPEKekfaMSNWNWMLKGLVKEYDGVDGLKTGSTPEAGDC 243
Cdd:NF038273 173 GSKKDDENKLSAKDVAIIARHLIKDFPEVLKITSKTSADFAGTT----IYSYNYMLKGMPYYREGVDGLKTGTTEKAGAS 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341 244 FTGTVERNGMRFISVVIKT----SSHTARFDETKKLYDYGFANFEVKQMYKKGSSVKgQETVRVENAKDKDVAVQTKQAI 319
Cdd:NF038273 249 FVATSVENGMRVITVVLNAdnadEDEYARFTATNQLLDYIYQNFEKVTLVKKGQAYK-DSKLPVIDGKKKTVSAVAKKDL 327

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 228822341 320 SLPVPKGSKDVYKTELKESSKGQEAPIKKGAALGQmvITPKDTND--PGFLtGKSLQVDLVTTSEVEEANW 388
Cdd:NF038273 328 TVIQKIGTDSKPSVKFTPKKKELTAPIKKGQVVGK--ATFKDKDLigKGYL-GEPPSVELVAKKDVKKSFF 395
DacC COG1686
D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis];
6-391 7.84e-113

D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441292 [Multi-domain]  Cd Length: 324  Bit Score: 333.34  E-value: 7.84e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341   6 ASAETGAALNIEAGAAILVEANSGKILYQKNADELLSIASMTKMMSEYLVHEAVDKGKLKWDQKIKVSEYAYKVsqdaSL 85
Cdd:COG1686   16 AAAAPAAPPDIAAKSAILIDADTGQVLYEKNADERLPPASLTKLMTAYVVLEALKAGKISLDDKVTVSEEAART----GG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341  86 SNVALENGGSYTVKELYEAMAIFSANGATIALAEAIAGKEVDFVKMMNDKSKELGLKNYKFVNSTGLTnkdlkgmhpegt 165
Cdd:COG1686   92 SKMGLKPGEQVTVEDLLKGLLLQSGNDAAVALAEHIAGSEEAFVALMNAKAKELGMTNTHFVNPTGLP------------ 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341 166 taDEENKMSAKDVATLAQHLIKDYPKVLDTAKIPKKEFrPEKEKFAMSNWNWMLkglvKEYDGVDGLKTGSTPEAGDCFT 245
Cdd:COG1686  160 --DPGHYSTARDLALLARAAIKDYPEFYEIFSTKEFTF-PNGRGITLRNTNRLL----GRYPGVDGLKTGYTDAAGYCLV 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341 246 GTVERNGMRFISVVIKTSSHTARFDETKKLYDYGFanfevkqmykkgssvkgqetvrvenakdkdvavqtkqaislpvPK 325
Cdd:COG1686  233 ASAKRGGRRLIAVVLGAPSEKARFADAAKLLDYGF-------------------------------------------PK 269

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 228822341 326 GSKDVYKTELKESSKgqeAPIKKGAALGQMVITpkdtndpgfLTGKSL-QVDLVTTSEVEEANWFTR 391
Cdd:COG1686  270 GEALKAEVVLDGPLK---APVKKGQVVGTLVVT---------LDGKTIaEVPLVAAEDVEKAGFFSR 324
Peptidase_S11 pfam00768
D-alanyl-D-alanine carboxypeptidase;
12-260 2.47e-83

D-alanyl-D-alanine carboxypeptidase;


Pssm-ID: 425859 [Multi-domain]  Cd Length: 234  Bit Score: 254.62  E-value: 2.47e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341   12 AALNIEAGAAILVEANSGKILYQKNADELLSIASMTKMMSEYLVHEAVDKGKLKWDQKIKVSEYAYKVSQDASlSNVALE 91
Cdd:pfam00768   2 SAPEIAAKSAILVDYNTGKVLYEKNPDQVRPIASITKLMTAYVVLEALKAGKIKEDDMVTISEDAWATGNPGS-SNIFLK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341   92 NGGSYTVKELYEAMAIFSANGATIALAEAIAGKEVDFVKMMNDKSKELGLKNYKFVNSTGLTNkdlkgmhpegttadEEN 171
Cdd:pfam00768  81 PGSQVSVKDLLRGALVSSGNDAAVALAEHIAGSEKAFVK*MNAKAKELGLKNTRFVNPTGLDA--------------HGQ 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341  172 KMSAKDVATLAQHLIKDYPKVLDTAKIPKKEFRpekekfAMSNWNWMLKGLVKEYDG--VDGLKTGSTPEAGDCFTGTVE 249
Cdd:pfam00768 147 YSSARDMAILAKALIKDLPEELSITKEKSFTFR------GINKINQRNRNGLLWDKTwnVDGLKTGYTNEAGYCLVASAT 220

                         250
                  ....*....|.
gi 228822341  250 RNGMRFISVVI 260
Cdd:pfam00768 221 KGGMRLISVVM 231
PBP4_Staph NF038258
penicillin-binding protein PBP4; Members of this family penicillin-binding protein 4 (PBP4), ...
 29-259 1.31e-55

penicillin-binding protein PBP4; Members of this family penicillin-binding protein 4 (PBP4), as the name is used in Staphylococcus aureus and related species from the same genus. PBP4 is not essential. It has transpeptidase activity, provides low level beta-lactam resistance, and in mutant strains can contribute to high level beta-lactam resistance.


Pssm-ID: 468436 [Multi-domain]  Cd Length: 365  Bit Score: 187.49  E-value: 1.31e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341  29 GKILYQKNADELLSIASMTKMMSEYLVHEAVDKGKLKWDQKIKVSEYAYKVSQDASLSNVALENGGSYTVKELYEAMAIF 108
Cdd:NF038258  50 GQILYDYHGNKKWDPASMTKLMTMYLTLEAIKKGKLSLNDKVKITSDYEKMSTLPNLSTFPLKPGQTYTIKELLKQTALA 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341 109 SANGATIALAEAIAGKEVDFVKMMNDKSKELGLKNYKFVNSTGLTNKDLKGMHPEGTTADEENKMSAKDVATLAQHLIKD 188
Cdd:NF038258 130 SSNAAALILAEKVSGNTSKFTDRMNEKAKALGMKHTHFTNPSGADNNLLKPYAPKKYKDETKSKSTAKDMAILSQHLIKK 209

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 228822341 189 YPKVLDTAKIPkkefRPEKEKFAMSNWNWMLKGLVKEYDGVDGLKTGSTPEAGDcFTGTVERNGMRFISVV 259
Cdd:NF038258 210 HPKILKYTKLT----ADTQHGVTLYTTNLSLPGQPMSLKGTDGLKTGTSDEGYN-LALTTKRDGLRINQVI 275
PRK10001 PRK10001
serine-type D-Ala-D-Ala carboxypeptidase;
2-415 2.62e-49

serine-type D-Ala-D-Ala carboxypeptidase;


Pssm-ID: 182189 [Multi-domain]  Cd Length: 400  Bit Score: 172.10  E-value: 2.62e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341   2 PYSNASAETGAALNIEAGAAILVEANSGKILYQKNADELLSIASMTKMMSEYLVHEAVDKGKLKWDQKIKVSEYAYKVSQ 81
Cdd:PRK10001  23 PTAFAAEQTVEAPSVDARAWILMDYASGKVLAEGNADEKLDPASLTKIMTSYVVGQALKADKIKLTDMVTVGKDAWATGN 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341  82 DA--SLSNVALENGGSYTVKELYEAMAIFSANGATIALAEAIAGKEVDFVKMMNDKSKELGLKNYKFVNSTGLtnkDLKG 159
Cdd:PRK10001 103 PAlrGSSVMFLKPGDQVSVADLNKGVIIQSGNDACIALADYVAGSQESFIGLMNGYAKKLGLTNTTFQTVHGL---DAPG 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341 160 MHPegttadeenkmSAKDVATLAQHLIKDYPKVLDTAKipKKEFRPEKEKFAMSN---WNWMLKglvkeydgVDGLKTGS 236
Cdd:PRK10001 180 QFS-----------TARDMALLGKALIHDVPEEYAIHK--EKEFTFNKIRQPNRNrllWSSNLN--------VDGMKTGT 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341 237 TPEAGDCFTGTVERNGMRFISVVIKTSSHTARFDETKKLYDYGFANFEVKQMYKKGSSVKGQetvRVENAKDKDVAVQTK 316
Cdd:PRK10001 239 TAGAGYNLVASATQGDMRLISVVLGAKTDRIRFNESEKLLTWGFRFFETVTPIKPDATFVTQ---RVWFGDKSEVNLGAG 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341 317 QAISLPVPKGSKDVYKTELKESSKGQEAPIKKGAALGQMVITpkdtndpgfLTGKSL-QVDLVTTSEVEEanwftramrg 395
Cdd:PRK10001 316 EAGSVTIPRGQLKNLKASYTLTEPQLTAPLKKGQVVGTIDFQ---------LNGKSIeQRPLIVMENVEE---------- 376

                        410       420
                 ....*....|....*....|
gi 228822341 396 iGSFFSGMWNSAVDTVKGWF 415
Cdd:PRK10001 377 -GGFFSRMWDFVMMKFHQWF 395
dacD PRK11397
serine-type D-Ala-D-Ala carboxypeptidase DacD;
16-391 2.59e-39

serine-type D-Ala-D-Ala carboxypeptidase DacD;


Pssm-ID: 183117 [Multi-domain]  Cd Length: 388  Bit Score: 144.96  E-value: 2.59e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341  16 IEAGAAILVEANSGKILYQKNADELLSIASMTKMMSEYLVHEAVDKGKLKWDQKIKVSEYAYK----VSQDASLsnVALE 91
Cdd:PRK11397  34 IDAGSWVLMDYTTGQILTAGNEHQQRNPASLTKLMTGYVVDRAIDSHRITPDDIVTVGRDAWAkdnpVFVGSSL--MFLK 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341  92 NGGSYTVKELYEAMAIFSANGATIALAEAIAGKEVDFVKMMNDKSKELGLKNYKFVNSTGLtnkDLKGMHPegttadeen 171
Cdd:PRK11397 112 EGDRVSVRDLSRGLIVDSGNDACVALADYIAGGQRQFVEMMNNYVEKLHLKDTHFETVHGL---DAPGQHS--------- 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341 172 kmSAKDVATLAQHLIKDYPkvldtakipkKEFRPEKEKFAmsNWNWMLK----GLVkeYD---GVDGLKTGSTPEAGDCF 244
Cdd:PRK11397 180 --SAYDLAVLSRAIIHGEP----------EFYHMYSEKSL--TWNGITQqnrnGLL--WDktmNVDGLKTGHTSGAGFNL 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341 245 TGTVERNGMRFISVVIKTSSHTARFDETKKLYDYGFANFEVKQMYKKGSSVkGQEtvRVENAKDKDVAVQTKQAISLPVP 324
Cdd:PRK11397 244 IASAVDGQRRLIAVVMGADSAKGREEQARKLLRWGQQNFTTVQILHRGKKV-GTE--RIWYGDKENIALGTEQDFWMVLP 320

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 228822341 325 KGSKDVYKTELKESSKGQEAPIKKGAALGQMVITPKDtndpgfltgKSL-QVDLVTTSEVEEANWFTR 391
Cdd:PRK11397 321 KAEIPHIKAKYVLDGKELEAPISAHQRVGEIELYDRD---------KQVaHWPLVTLESVGEGGMFSR 379
PRK10793 PRK10793
D-alanyl-D-alanine carboxypeptidase fraction A; Provisional
 15-400 6.83e-38

D-alanyl-D-alanine carboxypeptidase fraction A; Provisional


Pssm-ID: 182736 [Multi-domain]  Cd Length: 403  Bit Score: 141.53  E-value: 6.83e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341  15 NIEAGAAILVEANSGKILYQKNADELLSIASMTKMMSEYLVHEAVDKGKLKWDQKIKVSEYAYK----VSQDASLsnVAL 90
Cdd:PRK10793  43 QIDAESYILIDYNSGKVLAEQNADVRRDPASLTKMMTSYVIGQAMKAGKFKETDLVTVGNDAWAtgnpVFKGSSL--MFL 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341  91 ENGGSYTVKELYEAMAIFSANGATIALAEAIAGKEVDFVKMMNDKSKELGLKNYKFvnstgltnKDLKGMHPEGTTAdee 170
Cdd:PRK10793 121 KPGMQVPVSQLIRGINLQSGNDACVAMADYVAGSQDAFVGLMNSYVNALGLKNTHF--------QTVHGLDADGQYS--- 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341 171 nkmSAKDVATLAQHLIKDYPkvldtakipkKEFRPEKEK-FAMSNWNWMLK-GLVKEYD-GVDGLKTGSTPEAGDCFTGT 247
Cdd:PRK10793 190 ---SARDMALIGQALIRDVP----------NEYAIYKEKeFTFNGIRQLNRnGLLWDNSlNVDGIKTGHTDKAGYNLVAS 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341 248 VERNGMRFISVVIKTSSHTARFDETKKLYDYGFANFEVKQMYKKGSSVKGQ-----ETVRVENAKDKDVavqtkqaiSLP 322
Cdd:PRK10793 257 ATEGQMRLISAVMGGRTFKGRETESKKLLTWGFRFFETVNPLKVGKEFASEpvwfgDSDRASLGVDKDV--------YLT 328

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 228822341 323 VPKGSKDVYKTELKESSKGQEAPIKKGAALGQMVITpkdtndpgfLTGKSL-QVDLVTTSEVEEANWFTRAMRGIGSFF 400
Cdd:PRK10793 329 IPRGRMKDLKASYVLNTSELHAPLQKNQVVGTINFQ---------LDGKTIeQRPLVVLQEIPEGNFFGKIIDYIKLMF 398
pbpG PRK11669
D-alanyl-D-alanine endopeptidase; Provisional
 6-243 1.23e-17

D-alanyl-D-alanine endopeptidase; Provisional


Pssm-ID: 236952  Cd Length: 306  Bit Score: 82.81  E-value: 1.23e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341   6 ASAETGAALNIEAGAAILVEANSGKILYQKNADELLSIASMTKMMSEYLVHEAvdkgKLKWDQKIKVseyayKVSQDASL 85
Cdd:PRK11669  29 AATTASQPQEIASGSAMVVDLNTNKVIYSSNPDLVVPIASITKLMTAMVVLDA----KLPLDEKLKV-----DISQTPEM 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341  86 ----SNVALenGGSYTVKELYEAMAIFSANGATIALAEAIAGKEVDFVKMMNDKSKELGLKNYKFVNSTGLTnkdlkgmh 161
Cdd:PRK11669 100 kgvySRVRL--NSEISRKDMLLLALMSSENRAAASLAHHYPGGYKAFIKAMNAKAKALGMTNTRYVEPTGLS-------- 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341 162 pegttadEENKMSAKDVATLaqhLI--KDYPKVLDTAKIPKK-----------EFRPEKEKFAMSNWNWMLKglvkeydg 228
Cdd:PRK11669 170 -------IHNVSTARDLTKL---LIasKQYPLIGQLSTTREKtatfrkpnytlPFRNTNHLVYRDNWNIQLT-------- 231

                        250
                 ....*....|....*
gi 228822341 229 vdglKTGSTPEAGDC 243
Cdd:PRK11669 232 ----KTGFTNAAGHC 242
PBP5_C smart00936
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. ...
 283-385 1.39e-16

Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. coli functions as a D-alanyl-D-alanine carboxypeptidase. It is composed of two domains that are oriented at approximately right angles to each other. The N-terminal domain (pfam00768) is the catalytic domain. The C-terminal domain featured in this family is organized into a sandwich of two anti-parallel beta-sheets, and has a relatively hydrophobic surface as compared to the N-terminal domain. Its precise function is unknown; it may mediate interactions with other cell wall-synthesising enzymes, thus allowing the protein to be recruited to areas of active cell wall synthesis. It may also function as a linker domain that positions the active site in the catalytic domain closer to the peptidoglycan layer, to allow it to interact with cell wall peptides.


Pssm-ID: 198004 [Multi-domain]  Cd Length: 92  Bit Score: 74.56  E-value: 1.39e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341   283 FEVKQMYKKGSSVKgqeTVRVENAKDKDVAVQTKQAISLPVPKGSKDVYKTELKESSKGQEAPIKKGAALGQMVITpkdt 362
Cdd:smart00936   1 FETVKLYKKGQVVG---TVKVWKGKEKTVKLGAKEDVYVTLPKGEKKKLKAKVVLDKPELEAPIKKGQVVGTLVVT---- 73

                           90       100
                   ....*....|....*....|...
gi 228822341   363 nDPGFLTGKslqVDLVTTSEVEE 385
Cdd:smart00936  74 -LDGKLIGE---VPLVALEDVEK 92
PBP5_C pfam07943
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. ...
 283-385 4.60e-14

Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. coli functions as a D-alanyl-D-alanine carboxypeptidase. It is composed of two domains that are oriented at approximately right angles to each other. The N-terminal domain (pfam00768) is the catalytic domain. The C-terminal domain featured in this family is organized into a sandwich of two anti-parallel beta-sheets, and has a relatively hydrophobic surface as compared to the N-terminal domain. Its precise function is unknown; it may mediate interactions with other cell wall-synthesising enzymes, thus allowing the protein to be recruited to areas of active cell wall synthesis. It may also function as a linker domain that positions the active site in the catalytic domain closer to the peptidoglycan layer, to allow it to interact with cell wall peptides.


Pssm-ID: 429749 [Multi-domain]  Cd Length: 91  Bit Score: 67.23  E-value: 4.60e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341  283 FEVKQMYKKGSSVKgqeTVRVENAKDKDVAVQTKQAISLPVPKGSKDVYKTELkESSKGQEAPIKKGAALGQMVItpkdt 362
Cdd:pfam07943   1 FETKKLYKKGDVVK---KVKVWKGKKKTVPLGAKEDVYVTVPKGEKKKLKAKV-TLKKPLEAPIKKGQVVGKLEV----- 71

                          90       100
                  ....*....|....*....|....
gi 228822341  363 ndpgFLTGKSL-QVDLVTTSEVEE 385
Cdd:pfam07943  72 ----YLDGKLIgEVPLVAKEDVEE 91
PenP COG2367
Beta-lactamase class A [Defense mechanisms];
36-185 2.17e-10

Beta-lactamase class A [Defense mechanisms];


Pssm-ID: 441934 [Multi-domain]  Cd Length: 276  Bit Score: 61.07  E-value: 2.17e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341  36 NADELLSIASMTKMMSEYLVHEAVDKGKLKWDQKIKVSEyAYKVSQDASLSNvaLENGGSYTVKELYEAMAIFSANGATI 115
Cdd:COG2367   51 NADERFPAASTFKLPVLAAVLRQVDAGKLSLDERVTLTP-EDLVGGSGILQK--LPDGTGLTLRELAELMITVSDNTATN 127

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341 116 ALAEAIAGKEVdfvkmmNDKSKELGLKNykfvnstglTNKDLKGMHPEGTTADEENKMSAKDVATLAQHL 185
Cdd:COG2367  128 LLLRLLGPDAV------NAFLRSLGLTD---------TRLDRKEPDLNELPGDGRNTTTPRDMARLLAAL 182
Beta-lactamase2 pfam13354
Beta-lactamase enzyme family; This is the catalytic domain of class A beta-lactamases. It is ...
 36-188 1.03e-09

Beta-lactamase enzyme family; This is the catalytic domain of class A beta-lactamases. It is closely related to Beta-lactamase, pfam00144, the serine beta-lactamase-like superfamily, which contains the distantly related pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.


Pssm-ID: 463854 [Multi-domain]  Cd Length: 215  Bit Score: 58.05  E-value: 1.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341   36 NADELLSIASMTKMMSEYLVHEAVDKGKLKWDQKIKVSEyAYKVSQDASLSNvaLENGGSYTVKELYEAMAIFSANGATI 115
Cdd:pfam13354  16 NGDRSFPAASTIKVPILLAVLEQVDEGKLSLDERLTVTA-EDKVGGSGILQY--LPDGSQLSLRDLLTLMIAVSDNTATN 92

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 228822341  116 ALAEAIAGKEVdfvkmmNDKSKELGLKNykfvnstglTNKDLKGMHPEGTTADEENKMSAKDVATLAQHLIKD 188
Cdd:pfam13354  93 LLIDRLGLEAV------NARLRALGLRD---------TRLRRKLPDLRAADKGGTNTTTARDMAKLLEALYRG 150
AmpC COG1680
CubicO group peptidase, beta-lactamase class C family [Defense mechanisms];
1-75 1.96e-05

CubicO group peptidase, beta-lactamase class C family [Defense mechanisms];


Pssm-ID: 441286 [Multi-domain]  Cd Length: 355  Bit Score: 46.22  E-value: 1.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341   1 MPYSNASAETGAALNIEA---------------GAAILVeANSGKILYQK-------------NADELLSIASMTKMMSE 52
Cdd:COG1680    1 MKFAAAAPAAGLSADLAAldaaldaalaeggipGAAVAV-VRDGKVVYEKaygvadletgrpvTPDTLFRIASVTKSFTA 79

                         90       100
                 ....*....|....*....|...
gi 228822341  53 YLVHEAVDKGKLKWDQkiKVSEY 75
Cdd:COG1680   80 TAVLQLVEEGKLDLDD--PVSKY 100
Beta-lactamase pfam00144
Beta-lactamase; This family appears to be distantly related to pfam00905 and PF00768 ...
 19-75 3.74e-03

Beta-lactamase; This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.


Pssm-ID: 395092 [Multi-domain]  Cd Length: 327  Bit Score: 39.02  E-value: 3.74e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228822341   19 GAAILVeANSGKILYQK-------------NADELLSIASMTKMMSEYLVHEAVDKGKLKWDQkiKVSEY 75
Cdd:pfam00144  16 GVAVAV-TRDGKVVVDRgggvadleggrpvTADTLFRIASVTKTFTAAAVLQLVERGKLDLDD--PVSKY 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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