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Conserved domains on  [gi|256732409|gb|EEU45758|]
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predicted protein [Fusarium vanettenii 77-13-4]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 96-520 1.69e-34

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17330:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 349  Bit Score: 133.47  E-value: 1.69e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409  96 ALNSISPYLPDMVVSMpgIPPAEAGLYVGILASAFALAQLSTNFLWGYASDVIGRKPVLIMGTFALMCCFCVFGLCKQYW 175
Cdd:cd17330   11 GFGIVFPVLPFYVREF--NKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLW 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 176 QIVVVHVAMGLLNGNAACVPTVLGEVTDRSNQSRAFTYLPVIYSLGSITGPALGGILVgkvgNEFPYLAPNILAAALLAc 255
Cdd:cd17330   89 LLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLS----TPYGYALPFLVAAALAL- 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 256 sVVVVGIWFeetldksqvnfelpawvqkvlsWLPsqkppprrhswsarwprarshtqpllssgdsddsddeaeddddedt 335
Cdd:cd17330  164 -LNLVLVLF----------------------FLP---------------------------------------------- 174

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 336 kldparstwkeltgTTILVLCTYLVFQLSNISFNSLYPIFAATPPPAGrdllPSKIGVSLSVAGLASIIFQAFLFQPFKT 415
Cdd:cd17330  175 --------------PLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFS----PSQIGLLLALVGIAGILAQLLLIPRLAK 236

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 416 RVGNLgtyQFALLGLGISMVLMPWVGYADDKPLFGVGSgklwlylelgvvlILKNLCAVGGLSSVMLLITNSAPSHASlG 495
Cdd:cd17330  237 RLGER---KLLRLGLLLAIIGLLLLPFASSVPLLVLAA-------------AILAFGTGIVFPALSALLSKSVPSKEQ-G 299

                        410       420
                 ....*....|....*....|....*
gi 256732409 496 SLNGLAQTLSALGRSIGPFVSGALF 520
Cdd:cd17330  300 KAQGIIQSLQSLARIIGPLLAGPLY 324
 
Name Accession Description Interval E-value
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 96-520 1.69e-34

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 133.47  E-value: 1.69e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409  96 ALNSISPYLPDMVVSMpgIPPAEAGLYVGILASAFALAQLSTNFLWGYASDVIGRKPVLIMGTFALMCCFCVFGLCKQYW 175
Cdd:cd17330   11 GFGIVFPVLPFYVREF--NKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLW 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 176 QIVVVHVAMGLLNGNAACVPTVLGEVTDRSNQSRAFTYLPVIYSLGSITGPALGGILVgkvgNEFPYLAPNILAAALLAc 255
Cdd:cd17330   89 LLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLS----TPYGYALPFLVAAALAL- 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 256 sVVVVGIWFeetldksqvnfelpawvqkvlsWLPsqkppprrhswsarwprarshtqpllssgdsddsddeaeddddedt 335
Cdd:cd17330  164 -LNLVLVLF----------------------FLP---------------------------------------------- 174

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 336 kldparstwkeltgTTILVLCTYLVFQLSNISFNSLYPIFAATPPPAGrdllPSKIGVSLSVAGLASIIFQAFLFQPFKT 415
Cdd:cd17330  175 --------------PLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFS----PSQIGLLLALVGIAGILAQLLLIPRLAK 236

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 416 RVGNLgtyQFALLGLGISMVLMPWVGYADDKPLFGVGSgklwlylelgvvlILKNLCAVGGLSSVMLLITNSAPSHASlG 495
Cdd:cd17330  237 RLGER---KLLRLGLLLAIIGLLLLPFASSVPLLVLAA-------------AILAFGTGIVFPALSALLSKSVPSKEQ-G 299

                        410       420
                 ....*....|....*....|....*
gi 256732409 496 SLNGLAQTLSALGRSIGPFVSGALF 520
Cdd:cd17330  300 KAQGIIQSLQSLARIIGPLLAGPLY 324
MFS_1 pfam07690
Major Facilitator Superfamily;
95-513 1.44e-15

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 78.23  E-value: 1.44e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409   95 TALNSISPYLPDMVVSMPGIPPAEAGLyvgiLASAFALAQLSTNFLWGYASDVIGRKPVLIMGTFALMCCFCVFGLCKQY 174
Cdd:pfam07690  10 LGRSLLGPALPLLLAEDLGISPTEIGL----LLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409  175 WQIVVVHVAMGLLNG-NAACVPTVLGEVTDRSNQSRAFTYLPVIYSLGSITGPALGGILVGKVGNEFPYlapnILAAALL 253
Cdd:pfam07690  86 WLLLVLRVLQGLGAGaLFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAF----LILAILS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409  254 ACSVVVVGIWFEETLDKSQVNFElpawvqkvlswlpsQKPPPRRHSWSARWPRARshtqpllssgdsddsddeaedddde 333
Cdd:pfam07690 162 LLAAVLLLLPRPPPESKRPKPAE--------------EARLSLIVAWKALLRDPV------------------------- 202

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409  334 dtkldparstwkeltgttILVLCTYLVFQLSNISFNSLYPIFAATpppagRDLLPSKIGVSLSVAGLASIIFQaFLFQPF 413
Cdd:pfam07690 203 ------------------LWLLLALLLFGFAFFGLLTYLPLYQEV-----LGLSALLAGLLLGLGGLLGAIGR-LLLGRL 258

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409  414 KTRVGNLGTYQFALLGLGISMVLMPWVGYADDKPLFgvgsgklwlylelGVVLILKNLCAVGGLSSVMLLITNSAPSHAS 493
Cdd:pfam07690 259 SDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWL-------------LLALLLLGFGFGLVFPALNALVSDLAPKEER 325

                         410       420
                  ....*....|....*....|
gi 256732409  494 lGSLNGLAQTLSALGRSIGP 513
Cdd:pfam07690 326 -GTASGLYNTAGSLGGALGP 344
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
100-508 1.97e-14

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 74.63  E-value: 1.97e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 100 ISPYLPDMVVSMpGIPPAEAGLyvgiLASAFALAQLSTNFLWGYASDVIGRKPVLIMGTFALMCCFCVFGLCKQYWQIVV 179
Cdd:COG2814   29 VLPALPLIAADL-GASPAQAGL----VVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLA 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 180 VHVAMGLLNG-NAACVPTVLGEVTDRSNQSRAFTYLPVIYSLGSITGPALGGILVGKVGNEFPYLapniLAAALLACSVV 258
Cdd:COG2814  104 ARFLQGLGAGaLFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFL----VNAVLALLALL 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 259 VVGIWFEETldksqvnfelpawvqkvlswlpsqkPPPRRHSWSARWPRARSHTQpllssgdsddsddeaeddddedtkld 338
Cdd:COG2814  180 LLLRLLPES-------------------------RPAARARLRGSLRELLRRPR-------------------------- 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 339 parstwkeltgtTILVLCTYLVFQLSNISFNSLYPIFAAtpppAGRDLLPSKIGVSLSVAGLASIIFQaFLFQPFKTRVG 418
Cdd:COG2814  209 ------------LLLLLLLAFLLGFGFFALFTYLPLYLQ----EVLGLSASAAGLLLALFGLGGVLGA-LLAGRLADRFG 271

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 419 NLGTYQFALLGLGISMVLMPWVGYaddkplfgvgsgkLWLYLelgVVLILKNLCAVGGLSSVMLLITNSAPSHAsLGSLN 498
Cdd:COG2814  272 RRRLLLIGLLLLALGLLLLALAGS-------------LWLLL---LALFLLGFGFGLLFPLLQALVAELAPPEA-RGRAS 334

                        410
                 ....*....|
gi 256732409 499 GLAQTLSALG 508
Cdd:COG2814  335 GLYNSAFFLG 344
2_A_01_02 TIGR00880
Multidrug resistance protein;
124-267 1.28e-11

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 62.28  E-value: 1.28e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409  124 GILASAFALAQLSTNFLWGYASDVIGRKPVLIMGTFALMCCFCVFGLCKQYWQIVVVHVAMGLlnGNAACVPTVLGEVTD 203
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGF--GAAFALVAGAALIAD 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 256732409  204 RS---NQSRAFTYLPVIYSLGSITGPALGGILVGKVGNEFPYLapnILAAALLACSVVVVgIWFEET 267
Cdd:TIGR00880  79 IYppeERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFL---FLAILALAAFILLA-FLLPET 141
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
96-260 5.49e-04

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 42.60  E-value: 5.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409  96 ALNSISPYLPDMVVSMPGIPPAEAGLYVGILAS-AFALAQLSTNFlWGYASDVIGRKPVLIMGTFALMCCFCVFGLCKQY 174
Cdd:PRK09874  29 AFSLVMPFLPLYVEQLGVTGHSALNMWSGLVFSiTFLFSAIASPF-WGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNI 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 175 WQIVVVHVAMGLLNGNAACVPTVLGEVTDRSNQSRAFTYLPVIYSLGSITGPALGGILVGKVGNEFPYLapnILAAALLA 254
Cdd:PRK09874 108 WQFLILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSYGLRPVFF---ITASVLFL 184


                 ....*.
gi 256732409 255 CSVVVV 260
Cdd:PRK09874 185 CFLVTL 190
 
Name Accession Description Interval E-value
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 96-520 1.69e-34

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 133.47  E-value: 1.69e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409  96 ALNSISPYLPDMVVSMpgIPPAEAGLYVGILASAFALAQLSTNFLWGYASDVIGRKPVLIMGTFALMCCFCVFGLCKQYW 175
Cdd:cd17330   11 GFGIVFPVLPFYVREF--NKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLW 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 176 QIVVVHVAMGLLNGNAACVPTVLGEVTDRSNQSRAFTYLPVIYSLGSITGPALGGILVgkvgNEFPYLAPNILAAALLAc 255
Cdd:cd17330   89 LLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLS----TPYGYALPFLVAAALAL- 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 256 sVVVVGIWFeetldksqvnfelpawvqkvlsWLPsqkppprrhswsarwprarshtqpllssgdsddsddeaeddddedt 335
Cdd:cd17330  164 -LNLVLVLF----------------------FLP---------------------------------------------- 174

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 336 kldparstwkeltgTTILVLCTYLVFQLSNISFNSLYPIFAATPPPAGrdllPSKIGVSLSVAGLASIIFQAFLFQPFKT 415
Cdd:cd17330  175 --------------PLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFS----PSQIGLLLALVGIAGILAQLLLIPRLAK 236

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 416 RVGNLgtyQFALLGLGISMVLMPWVGYADDKPLFGVGSgklwlylelgvvlILKNLCAVGGLSSVMLLITNSAPSHASlG 495
Cdd:cd17330  237 RLGER---KLLRLGLLLAIIGLLLLPFASSVPLLVLAA-------------AILAFGTGIVFPALSALLSKSVPSKEQ-G 299

                        410       420
                 ....*....|....*....|....*
gi 256732409 496 SLNGLAQTLSALGRSIGPFVSGALF 520
Cdd:cd17330  300 KAQGIIQSLQSLARIIGPLLAGPLY 324
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 100-522 8.49e-21

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 94.57  E-value: 8.49e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 100 ISPYLPDMVVSMpGIPPAEaglyVGILASAFALAQLSTNFLWGYASDVIGRKPVLIMGTFALMCCFCVFGLCKQYWQIVV 179
Cdd:cd17325   15 IIPILPLYAESL-GASVAQ----IGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 180 VHVAMGLLngnAACVPTV----LGEVTDRSNQSRAFTYLPVIYSLGSITGPALGGILVGKVGNEFPYLapnILAAALLAC 255
Cdd:cd17325   90 ARFLQGLA---SAAVWPAamalIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFL---VCAALALLA 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 256 SVVvvgiwfeetldksqvnfelpawvqkVLSWLPSQKPPPRRHSWSARWPRARShtqpllssgdsddsddeaeddddedt 335
Cdd:cd17325  164 LVL-------------------------ALLLLPEPRPPPNKRAVSAARLRSGL-------------------------- 192

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 336 kldparstWKELTGTTILVLCTYLVFQLSNIS-FNSLYPIFAAtpppagrDLL---PSKIGVSLSVAGLASIIFQAFlfq 411
Cdd:cd17325  193 --------RLLLRDRRLLALFLAIFVLAFAFGaLEPFLPLYAA-------ELGglsPAQIGLLFGAQGLASALSQPP--- 254

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 412 pfktrVGNL----GTYQFALLGLGISMVLMPWVGYADDKPLFGVgsgkLWLYLELGVVLIlknlcavggLSSVMLLITNS 487
Cdd:cd17325  255 -----AGKLsdriGRKPLILIGLLLSAVALLLLPLATSFWLLLL----LLALLGLGLGLV---------FPATLALLADI 316

                        410       420       430
                 ....*....|....*....|....*....|....*
gi 256732409 488 APSHAsLGSLNGLAQTLSALGRSIGPFVSGALFTL 522
Cdd:cd17325  317 VPPEG-RGTAMGLFNTAFSLGMVLGPLLGGFLYDA 350
MFS_1 pfam07690
Major Facilitator Superfamily;
95-513 1.44e-15

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 78.23  E-value: 1.44e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409   95 TALNSISPYLPDMVVSMPGIPPAEAGLyvgiLASAFALAQLSTNFLWGYASDVIGRKPVLIMGTFALMCCFCVFGLCKQY 174
Cdd:pfam07690  10 LGRSLLGPALPLLLAEDLGISPTEIGL----LLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409  175 WQIVVVHVAMGLLNG-NAACVPTVLGEVTDRSNQSRAFTYLPVIYSLGSITGPALGGILVGKVGNEFPYlapnILAAALL 253
Cdd:pfam07690  86 WLLLVLRVLQGLGAGaLFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAF----LILAILS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409  254 ACSVVVVGIWFEETLDKSQVNFElpawvqkvlswlpsQKPPPRRHSWSARWPRARshtqpllssgdsddsddeaedddde 333
Cdd:pfam07690 162 LLAAVLLLLPRPPPESKRPKPAE--------------EARLSLIVAWKALLRDPV------------------------- 202

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409  334 dtkldparstwkeltgttILVLCTYLVFQLSNISFNSLYPIFAATpppagRDLLPSKIGVSLSVAGLASIIFQaFLFQPF 413
Cdd:pfam07690 203 ------------------LWLLLALLLFGFAFFGLLTYLPLYQEV-----LGLSALLAGLLLGLGGLLGAIGR-LLLGRL 258

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409  414 KTRVGNLGTYQFALLGLGISMVLMPWVGYADDKPLFgvgsgklwlylelGVVLILKNLCAVGGLSSVMLLITNSAPSHAS 493
Cdd:pfam07690 259 SDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWL-------------LLALLLLGFGFGLVFPALNALVSDLAPKEER 325

                         410       420
                  ....*....|....*....|
gi 256732409  494 lGSLNGLAQTLSALGRSIGP 513
Cdd:pfam07690 326 -GTASGLYNTAGSLGGALGP 344
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 100-524 2.40e-15

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 78.06  E-value: 2.40e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 100 ISPYLPDMVVSMpGIPPAEAGLYVGILASAFALAQLSTNFLWGYASDVIGRKPVLIMGTFALMCCFCVFGLCKQYWQIVV 179
Cdd:cd17388   18 IMPVLPTLLREF-VGDSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 180 VHVAMGLLNGNAACVPTVLGEVTDRSNQSRAFTYLPVIYSLGSITGPALGGILvGKVGNEFPYLApnilAAALLACSVVV 259
Cdd:cd17388   97 GRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLL-GEISPRAPFLV----AAGLNGLNFLL 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 260 VGIWFEETLdksqvnfelpawvqkvlswlpsqkPPPRRHswSARWPRArshtqpllssgdsddsddeaeddddedtklDP 339
Cdd:cd17388  172 GLFVLPESL------------------------PPERRR--AFRWRRA------------------------------NP 195

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 340 ARSTWKeLTGTTIL--VLCTYLVFQLSNISFNSLYPIFaatpppaGRDLL---PSKIGVSLSVAGLASIIFQAFLFQPFK 414
Cdd:cd17388  196 FGSLRW-LTGFPGLlgLLAVFFLIQLIGQVPATTWVLF-------TEDRFdwsPTMVGLSLAVFGLLHALFQAFVTGPIA 267

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 415 TRVGNLGTYQFALLGLGISMVLMPWVGYAddkplfgvgsgklWLYLelgVVLILknLCAvGGLSSVML--LITNSAPSHA 492
Cdd:cd17388  268 KRLGEKRAILLGLAADALGFLLLAFATQG-------------WMVF---PILIL--LAL-GGIAGPALqgLLSRQVPENE 328

                        410       420       430
                 ....*....|....*....|....*....|..
gi 256732409 493 SlGSLNGLAQTLSALGRSIGPFVSGALFTLST 524
Cdd:cd17388  329 Q-GELQGVLTSLTSLTSIIGPLLFTGIFAASP 359
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 95-260 6.89e-15

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 76.46  E-value: 6.89e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409  95 TALNSISPYLPDMVVSMPGIPPAEAGLYVGILASAFALAQLSTnflwGYASDVIGRKPVLIMGTFALMCCFCVFGLCKQY 174
Cdd:cd17325  213 FAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPA----GKLSDRIGRKPLILIGLLLSAVALLLLPLATSF 288

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 175 WQIVVVHVAMGLlnGNAACVPTV---LGEVTDRSNQSRAFTYLPVIYSLGSITGPALGGILVGKVGNEFPYLapnILAAA 251
Cdd:cd17325  289 WLLLLLLALLGL--GLGLVFPATlalLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFL---AAAAL 363


                 ....*....
gi 256732409 252 LLACSVVVV 260
Cdd:cd17325  364 LLLAAVLFL 372
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 122-550 1.82e-14

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 75.34  E-value: 1.82e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 122 YVGILASAFALAQLSTNFLWGYASDVIGRKPVLIMGTFALMCCFCVFGLCKQYWQIVVVHVAMGLLNG--NAAcVPTVLG 199
Cdd:cd17329   36 IVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGlfEPA-SEAMIA 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 200 EVTDRSNQSRAFTYLPVIYSLGSITGPALGGILVgkvgnEFPYLAPNILAAALLACSVVVVGIWFEETldksqVNFELPA 279
Cdd:cd17329  115 DVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLL-----LYSFRLLFLAAAVLFLLAALVLLFLLPET-----RPKRRAA 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 280 WVQKVLSWLPSqkppprrhswsarwprarshtqpllssgdsddsddeaeddddedTKLDPArstwkeltgtTILVLCTYL 359
Cdd:cd17329  185 EKTEILRGYKI--------------------------------------------VLRDRA----------FLLFLLASF 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 360 VFQLSNISFNSLYPIFAATPPPAGrdllPSKIGVSLSVAGLASIIFQAFLfqpfkTRVGNLGTYQFALLglgISMVLMPw 439
Cdd:cd17329  211 LISLIYFQLESTLPVYVVEILGLG----ESLLGLLLALNALLIVLLQFPV-----ARLVERFRLRKILM---IGILLFA- 277

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 440 VGYAddkplfGVGSGKLWLYLELGVVLIlknlcAVG---GLSSVMLLITNSAPSHAsLGSLNGLAQTLSALGRSIGPFVS 516
Cdd:cd17329  278 IGFA------VLAFANTLAVLILAMIVL-----TLGemlVFPAVQTLVAALAPPDK-RGSYMGFYALAWGLGRAIGPLVG 345

                        410       420       430
                 ....*....|....*....|....*....|....
gi 256732409 517 GALFTLstrihpkgeALAWSLFGGLAICGWIASL 550
Cdd:cd17329  346 GLLLDL---------LGPGLPWLILAALGLIAAA 370
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
100-508 1.97e-14

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 74.63  E-value: 1.97e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 100 ISPYLPDMVVSMpGIPPAEAGLyvgiLASAFALAQLSTNFLWGYASDVIGRKPVLIMGTFALMCCFCVFGLCKQYWQIVV 179
Cdd:COG2814   29 VLPALPLIAADL-GASPAQAGL----VVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLA 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 180 VHVAMGLLNG-NAACVPTVLGEVTDRSNQSRAFTYLPVIYSLGSITGPALGGILVGKVGNEFPYLapniLAAALLACSVV 258
Cdd:COG2814  104 ARFLQGLGAGaLFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFL----VNAVLALLALL 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 259 VVGIWFEETldksqvnfelpawvqkvlswlpsqkPPPRRHSWSARWPRARSHTQpllssgdsddsddeaeddddedtkld 338
Cdd:COG2814  180 LLLRLLPES-------------------------RPAARARLRGSLRELLRRPR-------------------------- 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 339 parstwkeltgtTILVLCTYLVFQLSNISFNSLYPIFAAtpppAGRDLLPSKIGVSLSVAGLASIIFQaFLFQPFKTRVG 418
Cdd:COG2814  209 ------------LLLLLLLAFLLGFGFFALFTYLPLYLQ----EVLGLSASAAGLLLALFGLGGVLGA-LLAGRLADRFG 271

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 419 NLGTYQFALLGLGISMVLMPWVGYaddkplfgvgsgkLWLYLelgVVLILKNLCAVGGLSSVMLLITNSAPSHAsLGSLN 498
Cdd:COG2814  272 RRRLLLIGLLLLALGLLLLALAGS-------------LWLLL---LALFLLGFGFGLLFPLLQALVAELAPPEA-RGRAS 334

                        410
                 ....*....|
gi 256732409 499 GLAQTLSALG 508
Cdd:COG2814  335 GLYNSAFFLG 344
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 121-268 1.08e-13

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 73.08  E-value: 1.08e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 121 LYVGILASAFALAQLSTNFLWGYASDVIGRKPVLIMGTFALMCCFCVFGLCKQYWQIVVVHVAMGLLNGNAACVPTVLGE 200
Cdd:cd17389   64 LFGGLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVAD 143

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 201 VTDRSNQSRAFTYLPVIYSLGSITGPALGGIL--VGKVGNEFPYLAPNILAAALLACSVVVVGIWFEETL 268
Cdd:cd17389  144 VTSPKKRSKGMALIGVAFSLGFIIGPMIGAYFasFTRSLGEVFFSMPALFALVLALADLLFIFFFLPETL 213
2_A_01_02 TIGR00880
Multidrug resistance protein;
124-267 1.28e-11

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 62.28  E-value: 1.28e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409  124 GILASAFALAQLSTNFLWGYASDVIGRKPVLIMGTFALMCCFCVFGLCKQYWQIVVVHVAMGLlnGNAACVPTVLGEVTD 203
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGF--GAAFALVAGAALIAD 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 256732409  204 RS---NQSRAFTYLPVIYSLGSITGPALGGILVGKVGNEFPYLapnILAAALLACSVVVVgIWFEET 267
Cdd:TIGR00880  79 IYppeERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFL---FLAILALAAFILLA-FLLPET 141
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 96-550 3.39e-10

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 62.06  E-value: 3.39e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409  96 ALNSISPYLPDMVVSMPGIPpaeagLYVGILASAFALAQLSTNFLWGYASDVIGRKPVLIMGTFALMCCFCVFGLCKQYW 175
Cdd:cd06174   11 ARGLISPLLPALLQSFGLSA-----SQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFW 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 176 QIVVVHVAMGLLNGN-AACVPTVLGEVTDRSNQSRAFTYLPVIYSLGSITGPALGGILVGKVGNEFPYLapNILAAALLA 254
Cdd:cd06174   86 LLLLGRFLLGLGSGLiDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAV--FLIAAALAL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 255 CSVVVVGIWFEETLDKSQVNFELPAWVQKVLSWLPSQKPPPrrhswsarwprarshtqpllssgdsddsddeaedddded 334
Cdd:cd06174  164 LAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPG--------------------------------------- 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 335 tkldparstwkeltgtTILVLCTYLVFQLSNISFNSLYPIFAATpppaGRDLLPSKIGVSLSVAGLASIIFQAFLFQPFK 414
Cdd:cd06174  205 ----------------LWLLLLAIFLVNLAYYSFSTLLPLFLLD----LGGLSVAVAGLLLSLFGLAGALGSLLLGLLSD 264

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 415 TRvgnLGTYQFALLGLGISMVLMPWVGYADDKPLFgvgsgkLWLYLELGVVLilknlcavGGLSSVMLLITNSAPSHASL 494
Cdd:cd06174  265 RL---IGRKPLLLIGLLLMALGLALLLLAPSLLLL------LLLLLLLGFGL--------GGLLPLSFALIAELFPPEIR 327

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 256732409 495 GSLNGLAQTLSALGRSIGPFVSGALFTLSTRIHpkgeaLAWSLFGGLAICGWIASL 550
Cdd:cd06174  328 GTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLT-----GAFLVLAVLLLLAAILLL 378
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
98-264 6.31e-10

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 61.04  E-value: 6.31e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409  98 NSISPYLPDMVVSMpGIPPAEAGLyvgiLASAFALAQLSTNFLWGYASDVIGRKPVLIMGTFALMCCFCVFGLCKQYWQI 177
Cdd:COG2271   27 SNLSVAAPPLQADL-GLSAAQLGL----LASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQL 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 178 VVVHVAMGLlnGNAACVP---TVLGEVTDRSNQSRAFTYLPVIYSLGSITGPALGGILVGKVGNEFPYLAPNILAAALLA 254
Cdd:COG2271  102 LLLRFLLGL--GEAGFFPaalKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLAL 179

                        170
                 ....*....|
gi 256732409 255 CSVVVVGIWF 264
Cdd:COG2271  180 LRFWLLALAY 189
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 124-521 8.21e-09

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 57.61  E-value: 8.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 124 GILASAFALAQLSTNFLWGYASDVIGRKPVLIMGTFALMCCFCVFGLCKQYWQIV---VVHVAMGLLNGNAACVPTVlge 200
Cdd:cd17331   38 GYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFlsrLPSVFMHAMQAAQMVVTDL--- 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 201 vTDRSNQSRAFTYLPVIYSLGSITGPALGGILVGKVGnefpYLAPNILAAALLACSVVVVGIwfeetldksqvnfelpaw 280
Cdd:cd17331  115 -TDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFG----EQAAALVAAVGSLLSIVLVIL------------------ 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 281 vqkvlsWLPSQKPPPRRHSwsarwprarshtqpllssgdsddsddeaedddDEDTKLDPARSTWKELTGTTIL-----VL 355
Cdd:cd17331  172 ------LIPSNTKSKREKE--------------------------------AKESASPPSVFNLKEILRLLRLpgvafLL 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 356 CTYLVFQLSNISFNSLYPIFAATPppagRDLLPSKIGVSLSVAGLASIIFQAFLFQPFKTRVGNLGTYQFALLGLGISMV 435
Cdd:cd17331  214 LVKLLSGLPIGMFQSMFSLVAMDF----FGLTPEENGYLMSYAGVLGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYL 289

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 436 LMPWVgyaddkplfgvgsGKLWLYLelgVVLILknLCAVGGLSSVML--LITNSAPShASLGSLNGLAQTLSALGRSIGP 513
Cdd:cd17331  290 LLAFV-------------TTVWQLL---VLLLP--LVIGGSVLYTVItsLLTKAVPP-EDTGTALGLSHALFSLVRTVSP 350


                 ....*...
gi 256732409 514 FVSGALFT 521
Cdd:cd17331  351 TIGGALLQ 358
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 98-520 1.06e-08

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 57.20  E-value: 1.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409  98 NSISPYLPDMVVSMpGIPPAEAGLyvgiLASAFALAQLSTNFLWGYASDVIGRKPVLIMG--TFALMCCFCvfGLCKQYW 175
Cdd:cd17474   16 SIVDPILPAIAEAL-GASPAQVGL----LITAFTLPAAVLMPVAGVLADRFGRKKVLLPGllLFGIGGLLC--GLSDSFA 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 176 QIVVVHVAMGLlnGNAACVP---TVLGEVTDRSNQSRAFTYLPVIYSLGSITGPALGGILVGkVGNEFPYLAPnilaaaL 252
Cdd:cd17474   89 LLLAGRALQGI--GAAGLGPlalTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLL------A 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 253 LACSVVVVGIWFeetldksqvnfelpawvqkvlsWLPSQKPPPRRHSWSARWPRARSHtqpllssgdsddsddeaedddd 332
Cdd:cd17474  160 ALIPVAFLAILF----------------------LLPEPKEKAKSSSATKLRDLKKAL---------------------- 195

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 333 edtkldparsTWKELTGTTILVLCTYLVFqlsnisfnslYPIFAATPPPAGR--DLLPSKIGVSLSVAGLASIIFQAFLF 410
Cdd:cd17474  196 ----------RGRGLLTFLVSAFLYFFLY----------FAFLTYLPFLLELlyGISPIIIGLLFAGWSVLLALGSLFVG 255

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 411 QPFKTRVGNLGTYQFALLGLGISMVLMPWVgyaddkplfgvgsGKLWLYLelgVVLILKNLCAVGGLSSVMLLITNSAPS 490
Cdd:cd17474  256 RLLKKRFGARRILVIGLLLYALSLLLLGFV-------------PSLALLL---IAIVLFGLGLGLNLPLLTTLVTELAPE 319

                        410       420       430
                 ....*....|....*....|....*....|..
gi 256732409 491 H--ASLGSLNGLAQTlsaLGRSIGPFVSGALF 520
Cdd:cd17474  320 EerGTASSLYNFVRF---LGQAVGPLLFGLLL 348
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 122-269 2.97e-08

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 55.70  E-value: 2.97e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 122 YVGILASAFALAQLSTNFLWGYASDVIGRKPVLIMGTFALMCCFCVFGLCKQYWQIVVVHVAMGLLNGNAACVPTVLGEV 201
Cdd:cd17390   32 VIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFKHTQSLCKAYLSDL 111

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 256732409 202 TDRSNQSRAFTYLPVIYSLGSITGPALGGILVGkVGNEFPYLApnILAAALLACSVVVVGIWFEETLD 269
Cdd:cd17390  112 VSEQERSRVLGRFNAASSLGFILGPVVGGHLAE-TDGGFYYVA--LLCSAIFILNAGLVWFLLSKLWD 176
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
94-222 3.91e-08

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 55.37  E-value: 3.91e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409  94 QTALNSISPYLPDMVVSMPGIPPAEAGLyvgiLASAFALAQLSTNFLWGYASDVIGRKPVLIMGTFALMCCFCVFGLCKQ 173
Cdd:COG2814  220 GFGFFALFTYLPLYLQEVLGLSASAAGL----LLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGS 295

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 256732409 174 YWQIVVVHVAMGLLNG-NAACVPTVLGEVTDRSNQSRAFTYLPVIYSLGS 222
Cdd:COG2814  296 LWLLLLALFLLGFGFGlLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
100-260 1.04e-07

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 54.12  E-value: 1.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 100 ISPYLPDMVVSMPGIPPAEAGLYVGILASAFALAQlstnFLWGYASDVIGRKPVL-IMGTFALMCCFCVFGLCKQYWQIV 178
Cdd:COG2223  224 FSSWLPPYLVDQFGLSAATAGLLAALFALLGALGR----PLGGWLSDRIGGRRVLlIVFALMALGLLLLALALGSLWLFL 299

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 179 VVHVAMGLLNG-NAACVPTVLGEVTDRSNQSRAFTYLPVIYSLGSITGPALGGILVGKVGNefpYLAPNILAAALLACSV 257
Cdd:COG2223  300 VLFLLLGLALGgGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGS---YTAAFLVFAVLALVAL 376


                 ...
gi 256732409 258 VVV 260
Cdd:COG2223  377 VLT 379
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 121-300 1.24e-07

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 54.09  E-value: 1.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 121 LYVGILASAFALAQLSTNFLWGYASDVIG-RKPVLIMGTFALMCCFCVFGLCKQYWQIVVvhVAMGLLNGNAACVPTVLG 199
Cdd:cd17471   32 LQIGIFMTLSALSGIVVSQWLGRLSDRGGdRKPLILLALLAGALGYLLFAFLRNYWVLLL--VGVVLLSLGAAAFPQLFA 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 200 ---EVTDRSNQSRAFTYLPVI---YSLGSITGPALGGILVGKVGNEFPYlapniLAAALLACSVVVVGIWFeetLDKSQV 273
Cdd:cd17471  110 larEYADRSSGRDATLFNSVLraaFSLAWVIGPPLAFLLLDVLGFTGLF-----LLAALLYLVVALLVLFL---LPSVKP 181

                        170       180
                 ....*....|....*....|....*..
gi 256732409 274 NfelpawVQKVLSWLPSQKPPPRRHSW 300
Cdd:cd17471  182 P------AQKATPASSLVKAPVNRRLL 202
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 120-520 5.21e-07

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 52.23  E-value: 5.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 120 GLYVGILASAFALAQLSTNFLWGYASDVIGRKPVLIMGTFALMCCFCVFGLC-----KQYWQIVVVHVAMGLLNG-NAAC 193
Cdd:cd06173   33 ALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLallgsLSLWLLLVLAFLLGIASAfFGPA 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 194 VPTVLGEVTDRSNQSRAFTYLPVIYSLGSITGPALGGILVGKVGNEFPYlapnILAAALLACSVVvvgiwfeetldksqv 273
Cdd:cd06173  113 RQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAF----AINALSFLLSAL--------------- 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 274 nfelpawvqkVLSWLPSQKPPPRRHSWSARWPRARshtqpllssgdsddsddeaeddddedtkldpARSTWKELTGTTIL 353
Cdd:cd06173  174 ----------LLLFIRRPPPAAPGESSSLLLRDLR-------------------------------EGLRYLRRSPLLRL 212

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 354 VLCTYLVFQLSNISFNSLYPIFAATPPPAGrdllPSKIGVSLSVAGLASIIfQAFLFQPFKTRVGNLGTYQFALLGLGIS 433
Cdd:cd06173  213 LLLALALFALLGGALTVLLPLLAKEVLGGG----AAGYGLLLAAFGVGALL-GALLLGRLSKRRRRGRLLLIGALLLGLA 287

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 434 MVLMPWVGYaddkplfgvgsgkLWLYLelgVVLILKNLCAVGGLSSVMLLITNSAPSHaSLGSLNGLAQTLSALGRSIGP 513
Cdd:cd06173  288 LLVLGLSPS-------------LWLLL---AALFLLGLAGGLFNVPLNTLLQLRVPDE-LRGRVFSVYNALNSGAMPLGA 350


                 ....*..
gi 256732409 514 FVSGALF 520
Cdd:cd06173  351 LLAGLLA 357
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
93-259 5.59e-07

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 52.16  E-value: 5.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409  93 EQTALNSISPYLpdmvVSMPGIPPAEAGLYVgilaSAFALAQLSTNFLWGYASDVIGRKPVLIMGTFALMCCFCVFGLCK 172
Cdd:COG0738  226 EGAIGDWLPLYL----KDVLGLSEATAALGL----SLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAP 297

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 173 QYWQIVVVHVAMGLlnGNAACVPTVLGEVTDR--SNQSRAFTYLPVIYSLGSITGPALGGILVGKVGNEFPYLAPNILAA 250
Cdd:COG0738  298 GPWLALIGLALVGL--GLSLMFPTIFSLALDGlgKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYL 375


                 ....*....
gi 256732409 251 ALLACSVVV 259
Cdd:COG0738  376 LILLLALAL 384
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
103-265 7.63e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 51.41  E-value: 7.63e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 103 YLPDMVVSMPGIPPAEAGLYVGILASAFALAQLstnfLWGYASDVIGR--KPVLIMGTFALMCCFCVFGLCKQYWQIVVV 180
Cdd:COG2271  202 WLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSL----LGGWLSDRLGRrrKLVLAIGLLLAALALLLLALLPSPALAIAL 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 181 HVAMGL-LNGNAACVPTVLGEVTDRSNQSRAFTYLPVIYSLGSITGPALGGILVGKVGNEFPYLapnILAAALLACSVVV 259
Cdd:COG2271  278 LFLAGFgLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFL---LLAALALLAALLA 354


                 ....*.
gi 256732409 260 VGIWFE 265
Cdd:COG2271  355 LLLLRE 360
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 94-270 1.01e-06

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 51.04  E-value: 1.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409  94 QTALNSISPYLPDMVVSMpGIPPAEAGLYVGILASAFALAQLstnfLWGYASDVIGRKPVLIMGT--FALMCCFCVFGlc 171
Cdd:cd17320   12 PLAIDMYLPALPAIARDL-GASASAVQLTLSAYLLGFALGQL----LYGPLSDRFGRRPVLLAGLllFILASLLCALA-- 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 172 KQYWQIVVVHVAMGLlngnAACVPTVLG-----EVTDRSNQSRAFTYLPVIYSLGSITGPALGGILVGKVGNEFPYLAPN 246
Cdd:cd17320   85 SSIEQLLIARFLQGL----GAAAGSVVAraivrDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLA 160

                        170       180
                 ....*....|....*....|....
gi 256732409 247 ILAAALLacsvVVVGIWFEETLDK 270
Cdd:cd17320  161 LLGLLLL----LLVLLFLPETLPE 180
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 95-237 1.92e-06

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 50.34  E-value: 1.92e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409  95 TALNSISPYLPDMVVSMPGIPPAEAGLYVGILASAFALAQLSTNFLWGYASDVIGRKPVLIMGTFALMCCFCVFGLCKQY 174
Cdd:cd17391   10 IGFSLIAPFLPLYIEQLGVTSGGLVELWSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNV 89

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 256732409 175 WQIVVVHVAMGLLNGNAACVPTVLGEVTDRSNQSRAFTYLPVIYSLGSITGPALGGILVGKVG 237
Cdd:cd17391   90 WQLLILRLLQGVFSGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFG 152
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 122-253 4.82e-06

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 48.65  E-value: 4.82e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 122 YVGILASAFALAQLSTNFLWGYASDVIGRKPVLIMGTFALMCCFCVFGLCKQYWQIVVVHVAMGL-LNGNAACVPTVLGE 200
Cdd:COG0477   50 QLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIgAGGLMPGALALIAE 129

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 256732409 201 VTDRSNQSRAFTYLPVIYSLGSITGPALGGILVGKVGNEFPYLAPNILAAALL 253
Cdd:COG0477  130 LFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLAL 182
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 127-234 1.08e-05

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 47.96  E-value: 1.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 127 ASAFALAQLSTNFLWGYASDVIGRKPVLImGTFALMCCFCV-FGLCKQYWQIVVVHVAMGLLNGNA-ACVPTVLGEVTDR 204
Cdd:cd17323   40 VSLFVLGFGLGPLIWAPLSELYGRRPVYL-VSLFIFVIFQIgCALAPNIAMLIILRFLQGFFGSSPlAIGAGTIADLFTP 118

                         90       100       110
                 ....*....|....*....|....*....|
gi 256732409 205 SNQSRAFTYlpviYSLGSITGPALGGILVG 234
Cdd:cd17323  119 EERGKAMGV----YSLGPLLGPALGPIIGG 144
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
94-552 1.78e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 47.20  E-value: 1.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409  94 QTALNSISPYLPDMVVSMPGIPPAEAGLYVGI--LASAFalaqlsTNFLWGYASDVIG-----RKPVLIMGTFALMCCFC 166
Cdd:COG2211   23 NLAFGLLSAYLLYFYTDVLGLSAALVGLILLVarLWDAI------TDPLIGALSDRTRtrwgrRRPWILIGAIPLALSFV 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 167 V------FGLCKQYWQIVVVHVAMGLLNgNAACVP--TVLGEVTDRSNQ-SRAFTYLPVIYSLGSITGPALGGILVGKVG 237
Cdd:COG2211   97 LlftapdLSPTGKLIYALVTYLLLGLAY-TLVNIPysALGAELTPDYEErTRLSSWRFAFAGLGGLLASVLPPPLVAAFG 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 238 NEFP--YLAPNILAAALLACSVVVVGIWFEETLdksqvnfelpawvqkvlswLPSQKPPPRRHSWsarwprarshtqpll 315
Cdd:COG2211  176 GDAAlgYRLTALIFAVLGLLAFLLTFFGTKERP-------------------VPEEEKVSLKESL--------------- 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 316 ssgdsddsddeaeddddedtkldpaRSTWKEltGTTILVLCTYLVFQLSNISFNSLYPIFAatpppagRDLL---PSKIG 392
Cdd:COG2211  222 -------------------------KALLKN--RPFLLLLLAYLLFFLALALVAALLLYYF-------KYVLglsAALVG 267

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 393 VSLSVAGLASIIFqAFLFQPFKTRVGNLGTYQFALLGLGISMVLMPWVGYADdkplfgvgsgkLWLYLelgVVLILKNLC 472
Cdd:COG2211  268 LLLALYFLAALLG-APLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGN-----------LWLLL---VLAALAGIG 332

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 473 AVGGLSSVMLLITNSAPSHASL------GSLNGLAQTLSALGRSIGPFVSGALFTLS---TRIHPKGEALAW--SLFGGL 541
Cdd:COG2211  333 LGAILVLPWAMLADVVDYDEWKtgrrreGLYFGIFTFAIKLGQALAGALAGLLLALFgyvAGAAQSPSALTGirLLFFLL 412

                        490
                 ....*....|.
gi 256732409 542 AICGWIASLFI 552
Cdd:COG2211  413 PAVLLLLAALL 423
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 95-259 1.91e-05

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 47.22  E-value: 1.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409  95 TALNSISPYLPDMVVSMPGIPPAEAGLYVGILAsafaLAQLSTNFLWGYASDVIGRKPVL-IMGTFALMCCFCVFGLCKQ 173
Cdd:cd17353  227 TAGLMLIGQAKPIGQEFAGLDAGIAALAVSILS----IFNGGGRPFWGWLSDKIGRKNTLsIAFLIQGVAMFLLPFIGSV 302

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 174 YWQIVVVHVAMGLLNG-NAACVPTVLGEVTDRSNQSRAFTYLPVIYSLGSItgpaLGGILVGKVGNEFPYLAPNILAAAL 252
Cdd:cd17353  303 AVLFVLGVALIGFCYGgGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGL----IGPIIAAYVLYTGGYNAAFIIAAAL 378


                 ....*..
gi 256732409 253 LACSVVV 259
Cdd:cd17353  379 SLVALAL 385
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 94-257 1.99e-05

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 47.04  E-value: 1.99e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409  94 QTALNSISPYLPDMVVSMPGIPPAEAGLYVGIlasaFALAQLSTNFLWGYASDVIGRKPVLIMGTFALM-CCFCVFGLCK 172
Cdd:cd06174  216 NLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSL----FGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMaLGLALLLLAP 291

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 173 QYWQIVVVHVAMGLLNGNAACVPTVL-GEVTDRSNQSRAFTYLPVIYSLGSITGPALGG-ILVGKVGNEFPYLAPNILAA 250
Cdd:cd06174  292 SLLLLLLLLLLLGFGLGGLLPLSFALiAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGfLLAATFGLTGAFLVLAVLLL 371


                 ....*..
gi 256732409 251 ALLACSV 257
Cdd:cd06174  372 LAAILLL 378
MFS_SLC18B1 cd17385
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ...
 112-262 2.15e-05

Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340943 [Multi-domain]  Cd Length: 390  Bit Score: 46.83  E-value: 2.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 112 PGIPPAEAGLYVGILASAFALaqlsTNFLWGYASDVIG-RKPVLIMGTFALMCCFCVFG------LCKQYWQIVVVHVAM 184
Cdd:cd17385  231 FKLSPGQVGLMFLILAGSYAI----SAPLWGWLSDKKKiPKWLMVIGSIITGVGFLLLGpapllpIKSELWMVIIGLVLL 306

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 185 GLLNGnAACVPT---VLGEVTDRSNQSRAFTYLPV------IYSLGSITGPALGGILVGKVGneFPYlapnilAAALLAC 255
Cdd:cd17385  307 GLSLG-AALVPTfpeLLNCAREYGFPDNLSTYGLVsglfnaAFSLGAFIGPTLGGFLLERLG--FEW------AATIQAG 377


                 ....*..
gi 256732409 256 SVVVVGI 262
Cdd:cd17385  378 LAFVVGI 384
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 124-266 2.91e-05

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 46.43  E-value: 2.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 124 GILASAFALAQLSTNFLWGYASDVIG-RKPVLIMGtFALMCCFCVFGLCKQY------WQIVVVHVAMGLLNGNAACVPT 196
Cdd:cd17326   39 GWVVAAYSLGQLVFSPVFGYWSNKTSsVKEPLIVS-ILIAIVGNILYALAEYfpsnrkYVMLVARFLIGVGAGNVAVLRA 117

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 256732409 197 VLGEVTDRSNQSRAFTYLPVIYSLGSITGPALGGILVG---KVGNEFP------YLAPNILAAALLACSVVVVGIWFEE 266
Cdd:cd17326  118 YVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFTPigyPGYVIGIklrfnmYTAPAWLMAILGIINIILILFFFKE 196
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
96-267 3.56e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 46.39  E-value: 3.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409  96 ALNSISPYLPDMVVSMpGIPPAEAGLyvgiLASAFALAQLSTNFLWGYASDVIGRKPVLIMGTFALMCCFCVFGLCKQYW 175
Cdd:COG0738   23 ATALWGPLIPALKDAF-GLSDAQAGL----LLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYP 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 176 QIVVVHVAMGLLNG--NAACVPTVLgeVTDRSNQSRAFTYLPVIYSLGSITGPALGGILVGKVGNEFPYLAPNILAAALL 253
Cdd:COG0738   98 LLLLALFLLGLGLGllDVAANPYVA--ALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPYLILAVLLL 175

                        170
                 ....*....|....
gi 256732409 254 ACSVVVVGIWFEET 267
Cdd:COG0738  176 LLALLFLRSKLPEI 189
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 102-260 3.77e-05

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 46.00  E-value: 3.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 102 PYLPDMVVSMPGIPPAEAGLYVGIlasaFALAQLSTNFLWGYASDVIGRKPVLIMGTFALMCCFCVFGLCKQYWQIVVVH 181
Cdd:cd17324  219 TYLAPFLTDVPGFSSSAIIGLLLL----FGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGL 294

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 182 VAMGLlnGNAACVPTVLGEVTDRSNQSRAFT---YLpVIYSLGSITGPALGGILVGKVGnefpYLAPNILAAALLACSVV 258
Cdd:cd17324  295 VLWGL--GFFAAHSALQTRVLRLAPEARGLAsslYL-AAYNLGGALGAALGGLVLDHGG----WAGVGWVGAALLLLALL 367


                 ..
gi 256732409 259 VV 260
Cdd:cd17324  368 LA 369
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 94-237 4.60e-05

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 46.10  E-value: 4.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409  94 QTALNSISPYLPDMVVSMPGIPPAEAgLYVGILASAFALAQLSTNFLWGYASDVIGRKPVLIMGTFALMCCFCVFGLCKQ 173
Cdd:cd17391  214 QLANQSIEPILTLYIRQLMGDASNLA-FISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQT 292

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 256732409 174 YWQIVVVHVAMGLLNGNA-ACVPTVLGEVTDRSNQSRAFTYLPVIYSLGSITGPALGGILVGKVG 237
Cdd:cd17391  293 PWQLGILRFLLGLATGGLlPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFG 357
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 95-521 9.63e-05

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 44.85  E-value: 9.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409  95 TALNSISPYLPDMVVSMpGIPPAEAGLYVGILASAFALAQLstnfLWGYASDVIGRKPVLIMGTFALMCCFCVFGLCKQY 174
Cdd:cd17324   13 TTEYVIQGLLPDIARDF-GVSVAQAGLLVSAYALGYALGAL----LLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSF 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 175 WQIVVVHVAMGLLNGN-AACVPTVLGEVTDRSNQSRAFTYLPVIYSLGSITGPALGGILvgkvGNEFPYLAPNILAAALL 253
Cdd:cd17324   88 ALLLLARALAGLAHGGfWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLL----GQLLGWRAAFLAIAVLA 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 254 ACSVVVVgiWFeetldksqvnfelpawvqkvlsWLPSQKPPPRRHSWS-ARWPRARSHTQPLLSSGDSDdsddeaedddd 332
Cdd:cd17324  164 LLAALLL--WR----------------------LLPSLPPKKPGSLGLlSSLLLLLRNPRLRLAYLITF----------- 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 333 edtkldparstwkeLTGTTILVLCTYLVFQLSNISFNSlypifaatpppagrdllPSKIGVSLSVAGLASIIfqaflFQP 412
Cdd:cd17324  209 --------------LLFGGFFALYTYLAPFLTDVPGFS-----------------SSAIIGLLLLFGVAGVV-----GSP 252

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 413 FKTRVGNLGTYQFALLGLGISMVLMpwvgyaddkPLFGVGSGKLWLyleLGVVLILKNLCAVGGLSSVMLLITNSAPSHA 492
Cdd:cd17324  253 LAGRLADRGGRRALLIALLLLAAAL---------LLLTLLGPSPLL---LLVGLVLWGLGFFAAHSALQTRVLRLAPEAR 320

                        410       420
                 ....*....|....*....|....*....
gi 256732409 493 SLGslNGLAQTLSALGRSIGPFVSGALFT 521
Cdd:cd17324  321 GLA--SSLYLAAYNLGGALGAALGGLVLD 347
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 103-259 1.12e-04

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 44.48  E-value: 1.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 103 YLPDMVVSMPGIPPAEAGLY-----VGILASAFALAQLSTNFlwgyasdvIGRKPVLIMGTFALMCCFCVFGLCKQYWQI 177
Cdd:cd17474  220 YLPFLLELLYGISPIIIGLLfagwsVLLALGSLFVGRLLKKR--------FGARRILVIGLLLYALSLLLLGFVPSLALL 291

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 178 VVVHVAMGLLNG-NAACVPTVLGEVTDRSNQSRAFTYLPVIYSLGSITGPALGGILVGKVGNEFPYLapnILAAALLACS 256
Cdd:cd17474  292 LIAIVLFGLGLGlNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFL---VGAAIALAAA 368


                 ...
gi 256732409 257 VVV 259
Cdd:cd17474  369 VLL 371
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 123-280 1.19e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 44.51  E-value: 1.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 123 VGILASAFALAQLSTNFLWGYASDVIGRKPVLIMGTFALMCCFCVFGLCKQYWQIVVVHVAMGLLNG-NAACVPTVLGEV 201
Cdd:cd17489   33 AGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGaFTTAAATLVADI 112

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 256732409 202 TDRSNQSRAFTYLPVIYSLGSITGPALGGILVGKVGneFPYLAPNILAAALLACsVVVVGIWFEETLDKSQVNFELPAW 280
Cdd:cd17489  113 IPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLG--FAVLFIVAAVLALLAL-LLVFLVKDPPPVAAEEAEAGTRAF 188
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
99-552 1.56e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 44.10  E-value: 1.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409  99 SISPYLPDMVVSMpGIPPAEAGLYVGILASAFALAQLstnfLWGYASDVIGRKPVLIMGTFALMCCFCVFGLCKQYWQIV 178
Cdd:COG2223   23 LWSVLAPPLAEEF-GLSAAQLGLLFAIPVLVGALLRI----PLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 179 VVHVAMGLLNG-NAACVPTVLGEVTDRSNQSRAFTYLPVIYSLGSITGPALGGILVGKVGNEFPYLapnILAAALLacsV 257
Cdd:COG2223   98 LLGLLLGIGGGgSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFL---ILGILLL---V 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 258 VVVGIWFeetldksqvnfelpawvqkVLSWLPSQKPPPRRHSWSARWPRARShtqpllssgdsddsddeaeddddedtkl 337
Cdd:COG2223  172 VAVLAWL-------------------FLRDPPAGAAAAAKASLRDQLEALRD---------------------------- 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 338 dpaRSTWkeltgttilVLCTYLVfqlsnISFNSLYPIFAATPPpagrdLLPSKIGVSLSVAGLASIIFQAF--LFQPF-- 413
Cdd:COG2223  205 ---PRFW---------LLSLLYF-----GTFGSFIGFSSWLPP-----YLVDQFGLSAATAGLLAALFALLgaLGRPLgg 262

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 414 --KTRVGNLGTYQFALLGLGISMVLMPWVgyaddkplfgvgSGKLWLYLELGVVLILknlCAVGGLSSVMLLITNSAPSH 491
Cdd:COG2223  263 wlSDRIGGRRVLLIVFALMALGLLLLALA------------LGSLWLFLVLFLLLGL---ALGGGNGAVFALVPDIFPTK 327

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 256732409 492 AsLGSLNGLAQTLSALGRSIGPFVSGALFTLStrihpKGEALAWSLFGGLAICGWIASLFI 552
Cdd:COG2223  328 N-AGAVYGLVGAAGGLGGFLGPLLFGALLDAT-----GSYTAAFLVFAVLALVALVLTLLL 382
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 123-255 2.06e-04

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 43.85  E-value: 2.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 123 VGILASAFALAQLSTNFLWGYASDVIGRKPVLIMGTFALMCCFCVFGLCKQYWQIVVVHVAMGLLNG-NAACVPTVLGEV 201
Cdd:cd17333   33 VSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGiLDTGANTFVGAL 112

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 256732409 202 TDRSnQSRAFTYLPVIYSLGSITGPALGGILVGKVGN-EFPYLAPNILAAALLAC 255
Cdd:cd17333  113 FEES-SATRLNVLHGFFGLGALIGPLIATSLLTSELSwSWAYLIIGLIYLLLAIL 166
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 350-552 2.08e-04

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 43.72  E-value: 2.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 350 TTILVLCTYLVFQLSNISFNSLYPIFAATPPPAGRDLLPSKIGVSLSVAGLASIIFqAFLFQPFKTRVGNLGTyqfALLG 429
Cdd:cd17504  178 NVLLANITALLAGFGMFMVFQLLPQLLQLPTPTGFGLGITEAGLLLLPGALVMLIA-GPLAGRLIARVGPRRV---LLIG 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 430 LGISMVlmpwvGYAddkpLFGVGSGKLWLYLELGVVLILKNLCAVgglSSVMLLITNSAPShASLGSLNGLAQTLSALGR 509
Cdd:cd17504  254 LVISAV-----GLL----LLALLHSSLWALVVALLLIGIGLGLAF---ASLPNIVVESVPP-DRTGIATGMNTVLRTIGS 320

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 256732409 510 SIGPFVSGALFTLSTRIHPKGEA-------LAWSLFGGLAICGWIASLFI 552
Cdd:cd17504  321 AIGPAIAGAILTTYTVSITSGGVptegayvLAFLIGAALALAALLLSLLI 370
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 103-259 4.00e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 42.97  E-value: 4.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 103 YLPDMVVSMPGIPPAEAGLYVGIlasaFALAQLSTNFLWGYASDVIGRKPVLIMGTFALMCCFCVFGLCKQ---YWQIVV 179
Cdd:cd17316  199 FLPTYLQTVLGLSPATSSLYLLL----ISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSgspTLLLLL 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 180 VHVAMGLLNGNAACVPTVLGEVTDrsNQSRAfTYLPVIYSLGSITGPALGGILVGKVGNEFPYLAPNILAAALLACSVVV 259
Cdd:cd17316  275 LFILSFFVGGVWGALYAYLAELFP--TEVRA-TGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIV 351
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 113-240 4.97e-04

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 42.61  E-value: 4.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 113 GIPPAEAGLyvgiLASAFALAQLSTNFLWGYASDVIGRKPVLIMGTF--ALMCCFCvfGLCKQYWQIVVVHVAMGLlnGN 190
Cdd:cd17328   30 LIDDSLAGL----LQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILiwSAATLLS--SFAPNFWQLLLFRALVGI--GE 101

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 256732409 191 AACV---PTVLGEVTDRSNQSRAFTylpvIYSLGSITGPALGGILVGKVGNEF 240
Cdd:cd17328  102 ASYSpiaPTIIADLFPKEKRTRALG----VFYFAIPLGSGLGYVVGGLVAQAT 150
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
96-260 5.49e-04

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 42.60  E-value: 5.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409  96 ALNSISPYLPDMVVSMPGIPPAEAGLYVGILAS-AFALAQLSTNFlWGYASDVIGRKPVLIMGTFALMCCFCVFGLCKQY 174
Cdd:PRK09874  29 AFSLVMPFLPLYVEQLGVTGHSALNMWSGLVFSiTFLFSAIASPF-WGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNI 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 175 WQIVVVHVAMGLLNGNAACVPTVLGEVTDRSNQSRAFTYLPVIYSLGSITGPALGGILVGKVGNEFPYLapnILAAALLA 254
Cdd:PRK09874 108 WQFLILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSYGLRPVFF---ITASVLFL 184


                 ....*.
gi 256732409 255 CSVVVV 260
Cdd:PRK09874 185 CFLVTL 190
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
388-552 6.94e-04

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 42.17  E-value: 6.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 388 PSKIGVSLSVAGLASIIFqAFLFQPFKTRVGNLgtyQFALLGLGISMVLmpwvGYAddkpLFGVGSGKLWLyleLGVVLI 467
Cdd:COG2807  249 AATAGLLLSLFQLAGIPG-SLLVPLLADRLGDR---RPLLLLLGLLGLA----GLL----GLLLAPGSLPW---LWAVLL 313

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 468 lkNLCAVGGLSSVMLLITNSAPSHASLGSLNGLAQTLSALGRSIGPFVSGALFTLStrihpKGEALAWSLFGGLAICGWI 547
Cdd:COG2807  314 --GLGQGGLFPLALTLIGLRARTPAEAAALSGMAQSVGYLLAALGPLLVGALHDAT-----GSWTAALLLLAALAVLMLV 386


                 ....*
gi 256732409 548 ASLFI 552
Cdd:COG2807  387 AGLLA 391
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
103-260 8.19e-04

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 42.17  E-value: 8.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 103 YLPDMVVSMpGIPPAEAGLyvgiLASAFALAQLSTNFLWGYASDVIGRKPVLIMGTFALMCC-FCVFGLCKQYWQIVVVh 181
Cdd:COG2807  237 WLPPILRDA-GLSAATAGL----LLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAgLLGLLLAPGSLPWLWA- 310

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 182 VAMGLlnGNAACVPTVLGEVTDRSNQSR------AFTYLpvIYSLGSITGPALGGILVGKVGNefpYLAPNILAAALLAC 255
Cdd:COG2807  311 VLLGL--GQGGLFPLALTLIGLRARTPAeaaalsGMAQS--VGYLLAALGPLLVGALHDATGS---WTAALLLLAALAVL 383


                 ....*
gi 256732409 256 SVVVV 260
Cdd:COG2807  384 MLVAG 388
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 113-292 8.76e-04

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 41.96  E-value: 8.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409  113 GIPPAEAGLyvgiLASAFALAQLSTNFLWGYASDVIGRKPVLIMGTFALMCCFCVFGLCKQYWQIVVVHVAMGL-LNGNA 191
Cdd:TIGR00895  48 GLDPVQLGF----LFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLgLGGLM 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409  192 ACVPTVLGEVTDRSNQSRAFTYLPVIYSLGSITGPALGGILVGKVGNEFPYLAPNILAAALLacsvVVVGIWFEETLD-- 269
Cdd:TIGR00895 124 PNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLL----LLLMRFLPESIDfl 199

                         170       180       190
                  ....*....|....*....|....*....|.
gi 256732409  270 --------KSQVNFELPAWVQKVLSWLPSQK 292
Cdd:TIGR00895 200 vskrpetvRRIVNAIAPQMQAEAQSALPEQK 230
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 123-290 1.10e-03

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 41.39  E-value: 1.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 123 VGILASAFALAQLSTNFLWGYASDVIGRKPVLIMGTFA--LMCCFCVFGLCKQYWQIVVVHVAMGLLNGNA-ACVPTVLG 199
Cdd:cd17380   36 QGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALwsLATLLTPLLAYSSLPLLILSRILLGLGEGVHfPSMTSLFS 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 200 EVTDRSNQSRAFTYLPVIYSLGSITGPALGGILVGKVGNEFPYLAPNILaaallacSVVVVGIWFeetldksqvNFELPA 279
Cdd:cd17380  116 RWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLL-------GLLWALVWL---------IYLPPV 179

                        170       180
                 ....*....|....*....|...
gi 256732409 280 WVQKV------------LSWLPS 290
Cdd:cd17380  180 WAIIVahfcmnwgfyilLSWLPT 202
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 96-553 1.15e-03

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 41.42  E-value: 1.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409  96 ALNSISPYLPDMVVSMpGIPPAEaglyVGILASAFALAQLSTNFLWGYASDVIGRKPVLIMGTFALMCCFCV--FGLCKQ 173
Cdd:cd17335   12 ALGSLLPFLSVYLKQL-GLSPTQ----IGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLslFFVAQI 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 174 YWQIVVVHVAMGLLngNAACVPTV-------LGEVTDRSNQSRAFTylpviySLGSITGPALGGILVGKVGNEFPYLAPN 246
Cdd:cd17335   87 FWLLLLLVILGAFF--SAPVVPLVdsitlqyLGEERERYGKQRLWG------SIGFGIAALLVGILIDRSSTYKNYTIAF 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 247 ILAAALLACSVVVVgiwfeetldkSQVNFelpawvqkvlswlpsqKPPPRRHSWSARWPRArshtqpLLssgdsddsdde 326
Cdd:cd17335  159 YVFAVLMLLALLLA----------LKFPF----------------RPKHPEPNENTGGLLA------LL----------- 195

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 327 aeddddedtkldparstwkeLTGTTILVLCTYLVFQLSNISFNSLYPIFAatpppagRDL--LPSKIGVSLSVAGLASII 404
Cdd:cd17335  196 --------------------RNPRVLAFLLVAFLMGFGHGLIYSFLFWHL-------QDLggSKTLIGLLWTVGVVSEIP 248

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 405 FQAFLFQPFKtRVGNLGtyqfaLLGLGISMVLMPWVGYADDKPlfgvgsgkLWLyleLGVVLILKNLCAVGGLSSVMLLI 484
Cdd:cd17335  249 FFFFSSRLIQ-RFGHVG-----LLYLGLLAYVVRWLLYSFLEN--------PWL---VLPIELLHGLTFALVWAAAVSYA 311

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 256732409 485 TNSAPSHASLGSLNGLAQTLSALGRSIGPFVSGALFtlstriHPKGEALAWSLFGGLAICGWIASLFIH 553
Cdd:cd17335  312 SAAAPPGLRATAQGLLQGLYFGLGGGLGSLIGGYLY------EAFGARTTFRFFAIAALAGLLAFFLIQ 374
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 103-263 1.36e-03

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 41.38  E-value: 1.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 103 YLPDMVVSMpGIPPAEAGLyvgiLASAFALAQLSTNFLWGYASD--VIGRKPVLIMGTFALMCCFCVFGLCKQYWQIVVV 180
Cdd:cd17352  205 YLPSYAKSL-GIDESDAAF----LLSIIGISDIVGRILLGLLADkpRIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVF 279

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 181 HVAMGLLNGNAACV-PTVLGEVTDRSNQSRAFTYLPVIYSLGSITGPALGGILVGKVGNefpYLAPNILAAALLACSVVV 259
Cdd:cd17352  280 SVLFGFCSGSYSSLtPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGD---YDAAFYFCGACLLLSGVL 356


                 ....
gi 256732409 260 VGIW 263
Cdd:cd17352  357 LFLL 360
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
103-168 1.54e-03

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 41.03  E-value: 1.54e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 256732409 103 YLPD---MVVSMpGIPPAEAGLYVGILASAFALAQLstnfLWGYASDVIGRKPVLIMG--TFALMCCFCVF 168
Cdd:PRK11043  25 YLPAfkaIQADL-QTSASAVSASLSLFLAGFALGQL----LWGPLSDRYGRKPVLLAGlsLFALGSLGMLW 90
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 123-254 1.54e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 41.00  E-value: 1.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 123 VGILASAFALAQLSTNFLWGYASDVIGRKPVLIMGTFALMCCFCVFGLCKQYWqiVVVHVAMGLLNGNAACVPTV----L 198
Cdd:cd17477  225 AALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLP--LALLVLLFLWGGAAGPLYTLalalA 302

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 256732409 199 GEVTDRSNQSRAFTYLPVIYSLGSITGPALGGILVGKVGNEFPYLAPNILAAALLA 254
Cdd:cd17477  303 GDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLL 358
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 104-233 1.99e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 40.62  E-value: 1.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 104 LPDMVVSMpGIPPAEaglyVGILASAFALAQLSTNFLWGYASDVIGRKPVLIMGT--FALMCCFCvfGLCKQYWQIVVVH 181
Cdd:cd17321   19 LPTIARDL-GASPSQ----LQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLalFGLASLLC--ALAPSLAFLIAAR 91

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 256732409 182 VAMGLlnGNAACVPTVLGEVTD---RSNQSRAFTYLPVIYSLGSITGPALGGILV 233
Cdd:cd17321   92 ALQGI--GAAAIMPASLALIAAtfpGERRGRALGLWGAVVGIGAALGPLLGGLLL 144
Sugar_tr pfam00083
Sugar (and other) transporter;
115-202 2.16e-03

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 40.72  E-value: 2.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409  115 PPAEAGLYVGILASAFALAQLSTNFLWGYASDVIGRKPVLIMGTFalmcCFCVFGLC-------KQYWQIVVVHVAMGL- 186
Cdd:pfam00083  40 SLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANV----LFVIGAVLqgaakgkWSVYQLIVGRVLVGIg 115

                          90
                  ....*....|....*.
gi 256732409  187 LNGNAACVPTVLGEVT 202
Cdd:pfam00083 116 VGGASVLAPMYISEIA 131
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 123-237 2.80e-03

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 40.24  E-value: 2.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 123 VGILASAFALAQLSTNFLWGYASDVIGRKPVLIMGT--FALMCCFCvfGLCKQYWQIVVVHVAMGLlnGNAACVP---TV 197
Cdd:cd17502   32 VSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIviFELGSLLC--GLAPNMTMLIVGRAIQGI--GGGGLMSlafII 107

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 256732409 198 LGEVTDRSNQSRAFTYLPVIYSLGSITGPALGGILVGKVG 237
Cdd:cd17502  108 IADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLS 147
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 113-233 7.25e-03

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 38.90  E-value: 7.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409  113 GIPPAEAGLYVGILASAFALAQLstnfLWGYASDVIGRKPVLIMGT--FALMCCFCVFGlckqywQIVVVHVAMGLLNGN 190
Cdd:TIGR00710  36 STPASIVQMTLTLYLLGFAAGQL----LWGPLSDRYGRRPVLLLGLfiFALSSLGLALS------NNIETLLVLRFVQAF 105

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 256732409  191 AACVPTVLGE--VTD---RSNQSRAFTYLPVIYSLGSITGPALGGILV 233
Cdd:TIGR00710 106 GASAGSVISQalVRDiypGEELSRIYSILMPVLALAPAVAPLLGGYIL 153
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 108-162 7.43e-03

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 39.05  E-value: 7.43e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 256732409 108 VVSMPGIPPAEAgLYVGILASAFALAqlsTNFLWGYASDVIGRKPVLIMGTFALM 162
Cdd:cd17369  255 ATQTLGVDRSTV-LLAVLIASVVAAI---TIPLFGWLSDRVGRRPVYLAGALLAA 305
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 123-233 8.80e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 38.74  E-value: 8.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 123 VGILASAFALAQLSTNFLWGYASDVIGRKPVLIMgTFALMCCFCVF-GLCKQYWQIVVVHVAMGL-LNGNAACVPTVLGE 200
Cdd:cd17316   38 TGLLFAAGFLGRPIGALLFGYLGDRIGRKKALIL-TLLLFGLATLLiGLLPTPILLLVLRFLQGIgIGGEYPGASTYVAE 116

                         90       100       110
                 ....*....|....*....|....*....|...
gi 256732409 201 VTDRSNQSRAFTYLPVIYSLGSITGPALGGILV 233
Cdd:cd17316  117 FAPSKRRGFALGLLQSGWALGALLAALVASLLI 149
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 94-253 8.88e-03

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 38.71  E-value: 8.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409  94 QTALNSISPYLpdmVVSMPGIPPAEAGLYVGILASAFALAQLstnFLWGYASDVIGRKPVLIMGTFALMCCFCVFGLCkq 173
Cdd:cd17330  190 FAGLESVFSLF---LKDRFGFSPSQIGLLLALVGIAGILAQL---LLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFA-- 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256732409 174 yWQIVVVHVAMGLLN-GNAACVPTVLGEV---TDRSNQSRAFTYLPVIYSLGSITGPALGGILVGKVGNEFPYLAPNILA 249
Cdd:cd17330  262 -SSVPLLVLAAAILAfGTGIVFPALSALLsksVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLL 340


                 ....
gi 256732409 250 AALL 253
Cdd:cd17330  341 LIAL 344
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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