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Conserved domains on  [gi|296431537|gb|EFH17351|]
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SIS domain protein [Clostridioides difficile NAP07]

Protein Classification

MurR/RpiR family transcriptional regulator( domain architecture ID 11448252)

MurR/RpiR family transcriptional regulator similar to Escherichia coli MurR, which represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid

CATH:  1.10.10.10
Gene Ontology:  GO:0006355|GO:0003700|GO:0003677
PubMed:  15808743|8576032
SCOP:  4000148

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RpiR COG1737
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ...
 1-244 4.98e-46

DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];


:

Pssm-ID: 441343 [Multi-domain]  Cd Length: 286  Bit Score: 155.47  E-value: 4.98e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296431537   1 MRLEEMIFLNYNKLNETDLLIWKYITANKKHCSKMSINELAMKCNVSRATITRFVKKLDLKGFSEFKVLLSWE------- 73
Cdd:COG1737    5 MSLLERIRARYPSLSPSERRIADYILDNPEEVAFMSIAELAEAAGVSEATVVRFCRKLGFSGFPELKLALAQElaeglss 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296431537  74 SEKVHVIE---------NQSFDIACNSIIKYVEDQKNKDYDALCKLLYESRTIYAYGSGdIQNVVAKQIKRMFLSCQE-- 142
Cdd:COG1737   85 YERLRRLSpddsledilAKVLEAEIANLEETLELLDEEALERAVDLLAKARRIYIFGVG-ASAPVAEDLAYKLLRLGKnv 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296431537 143 IIYDFEGRTFDDSFYNIvSKNDVMIIISLSGENENTLNIARRLKLIGTKIISITEFKNNTLTDLSDESIYISATNISFLQ 222
Cdd:COG1737  164 VLLDGDGHLQAESAALL-GPGDVVIAISFSGYTRETLEAARLAKERGAKVIAITDSPLSPLAKLADVVLYVPSEEPTLRS 242

                        250       260
                 ....*....|....*....|..
gi 296431537 223 MHPSYKLTMLYfiLIELLFIKY 244
Cdd:COG1737  243 SAFSSRVAQLA--LIDALAAAV 262
 
Name Accession Description Interval E-value
RpiR COG1737
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ...
 1-244 4.98e-46

DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];


Pssm-ID: 441343 [Multi-domain]  Cd Length: 286  Bit Score: 155.47  E-value: 4.98e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296431537   1 MRLEEMIFLNYNKLNETDLLIWKYITANKKHCSKMSINELAMKCNVSRATITRFVKKLDLKGFSEFKVLLSWE------- 73
Cdd:COG1737    5 MSLLERIRARYPSLSPSERRIADYILDNPEEVAFMSIAELAEAAGVSEATVVRFCRKLGFSGFPELKLALAQElaeglss 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296431537  74 SEKVHVIE---------NQSFDIACNSIIKYVEDQKNKDYDALCKLLYESRTIYAYGSGdIQNVVAKQIKRMFLSCQE-- 142
Cdd:COG1737   85 YERLRRLSpddsledilAKVLEAEIANLEETLELLDEEALERAVDLLAKARRIYIFGVG-ASAPVAEDLAYKLLRLGKnv 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296431537 143 IIYDFEGRTFDDSFYNIvSKNDVMIIISLSGENENTLNIARRLKLIGTKIISITEFKNNTLTDLSDESIYISATNISFLQ 222
Cdd:COG1737  164 VLLDGDGHLQAESAALL-GPGDVVIAISFSGYTRETLEAARLAKERGAKVIAITDSPLSPLAKLADVVLYVPSEEPTLRS 242

                        250       260
                 ....*....|....*....|..
gi 296431537 223 MHPSYKLTMLYfiLIELLFIKY 244
Cdd:COG1737  243 SAFSSRVAQLA--LIDALAAAV 262
SIS_RpiR cd05013
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many ...
 102-243 2.09e-23

RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate isomerases that catalyze the reversible reactions of ribose 5-phosphate into ribulose 5-phosphate.


Pssm-ID: 240144 [Multi-domain]  Cd Length: 139  Bit Score: 92.29  E-value: 2.09e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296431537 102 KDYDALCKLLYESRTIYAYGSGDiQNVVAKQIKRMFLSCQEIIYDFEGRTFDDSFYNIVSKNDVMIIISLSGENENTLNI 181
Cdd:cd05013    1 EALEKAVDLLAKARRIYIFGVGS-SGLVAEYLAYKLLRLGKPVVLLSDPHLQLMSAANLTPGDVVIAISFSGETKETVEA 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 296431537 182 ARRLKLIGTKIISITEFKNNTLTDLSDESIYISATNISFLQMHPSYKLTMLYfiLIELLFIK 243
Cdd:cd05013   80 AEIAKERGAKVIAITDSANSPLAKLADIVLLVSSEEGDFRSSAFSSRIAQLA--LIDALFLA 139
HTH_6 pfam01418
Helix-turn-helix domain, rpiR family; This domain contains a helix-turn-helix motif. The best ...
 1-73 1.24e-16

Helix-turn-helix domain, rpiR family; This domain contains a helix-turn-helix motif. The best characterized member of this family is Swiss:P39266. RpiR is a regulator of the expression of rpiB gene.


Pssm-ID: 334531 [Multi-domain]  Cd Length: 77  Bit Score: 72.36  E-value: 1.24e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 296431537    1 MRLEEMIFLNYNKLNETDLLIWKYITANKKHCSKMSINELAMKCNVSRATITRFVKKLDLKGFSEFKVLLSWE 73
Cdd:pfam01418   1 MGLLEKIQSRYSKLTKSERKIADYILAHPDLAIHLSISAIAKAAGVSEATIVRFCQKLGFSGFPELKLALAGE 73
PRK11337 PRK11337
MurR/RpiR family transcriptional regulator;
1-208 7.36e-12

MurR/RpiR family transcriptional regulator;


Pssm-ID: 183089 [Multi-domain]  Cd Length: 292  Bit Score: 64.01  E-value: 7.36e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296431537   1 MRLEEMIFLnynklnETDLLIWkyITANKKHCSKMSINELAMKCNVSRATITRFVKKLDLKGFSEFKVLLS-WESEKVHV 79
Cdd:PRK11337  21 MKQEGLTPL------ESRVVEW--LLKPGDLSEATALKDIAEALAVSEAMIVKVAKKLGFSGFRNLRSALEdYFSQSEQV 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296431537  80 IENQ-SFDIACNSIIKYV---------EDQKNKDYDAL---CKLLYESRTIYAYGSGDiQNVVAKQIKRMFL----SCQe 142
Cdd:PRK11337  93 LHSElSFDDAPQDVVNKVfntslqaieETQSILDVDEFhraARFFYQARQRDLYGAGG-SAAIARDVQHKFLrigvRCQ- 170

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 296431537 143 iiydfegrTFDDSFYNIVS-----KNDVMIIISLSGENENTLNIARRLKLIGTKIISITEFKNNTLTDLSD 208
Cdd:PRK11337 171 --------AYDDAHIMLMSaallqEGDVVLVVSHSGRTSDVIEAVELAKKNGAKIICITNSYHSPIAKLAD 233
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
35-63 1.01e-03

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 37.57  E-value: 1.01e-03
                           10        20
                   ....*....|....*....|....*....
gi 296431537    35 MSINELAMKCNVSRATITRFVKKLDLKGF 63
Cdd:smart00347  25 LSVSELAKRLGVSPSTVTRVLDRLEKKGL 53
 
Name Accession Description Interval E-value
RpiR COG1737
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ...
 1-244 4.98e-46

DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];


Pssm-ID: 441343 [Multi-domain]  Cd Length: 286  Bit Score: 155.47  E-value: 4.98e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296431537   1 MRLEEMIFLNYNKLNETDLLIWKYITANKKHCSKMSINELAMKCNVSRATITRFVKKLDLKGFSEFKVLLSWE------- 73
Cdd:COG1737    5 MSLLERIRARYPSLSPSERRIADYILDNPEEVAFMSIAELAEAAGVSEATVVRFCRKLGFSGFPELKLALAQElaeglss 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296431537  74 SEKVHVIE---------NQSFDIACNSIIKYVEDQKNKDYDALCKLLYESRTIYAYGSGdIQNVVAKQIKRMFLSCQE-- 142
Cdd:COG1737   85 YERLRRLSpddsledilAKVLEAEIANLEETLELLDEEALERAVDLLAKARRIYIFGVG-ASAPVAEDLAYKLLRLGKnv 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296431537 143 IIYDFEGRTFDDSFYNIvSKNDVMIIISLSGENENTLNIARRLKLIGTKIISITEFKNNTLTDLSDESIYISATNISFLQ 222
Cdd:COG1737  164 VLLDGDGHLQAESAALL-GPGDVVIAISFSGYTRETLEAARLAKERGAKVIAITDSPLSPLAKLADVVLYVPSEEPTLRS 242

                        250       260
                 ....*....|....*....|..
gi 296431537 223 MHPSYKLTMLYfiLIELLFIKY 244
Cdd:COG1737  243 SAFSSRVAQLA--LIDALAAAV 262
SIS_RpiR cd05013
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many ...
 102-243 2.09e-23

RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate isomerases that catalyze the reversible reactions of ribose 5-phosphate into ribulose 5-phosphate.


Pssm-ID: 240144 [Multi-domain]  Cd Length: 139  Bit Score: 92.29  E-value: 2.09e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296431537 102 KDYDALCKLLYESRTIYAYGSGDiQNVVAKQIKRMFLSCQEIIYDFEGRTFDDSFYNIVSKNDVMIIISLSGENENTLNI 181
Cdd:cd05013    1 EALEKAVDLLAKARRIYIFGVGS-SGLVAEYLAYKLLRLGKPVVLLSDPHLQLMSAANLTPGDVVIAISFSGETKETVEA 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 296431537 182 ARRLKLIGTKIISITEFKNNTLTDLSDESIYISATNISFLQMHPSYKLTMLYfiLIELLFIK 243
Cdd:cd05013   80 AEIAKERGAKVIAITDSANSPLAKLADIVLLVSSEEGDFRSSAFSSRIAQLA--LIDALFLA 139
HTH_6 pfam01418
Helix-turn-helix domain, rpiR family; This domain contains a helix-turn-helix motif. The best ...
 1-73 1.24e-16

Helix-turn-helix domain, rpiR family; This domain contains a helix-turn-helix motif. The best characterized member of this family is Swiss:P39266. RpiR is a regulator of the expression of rpiB gene.


Pssm-ID: 334531 [Multi-domain]  Cd Length: 77  Bit Score: 72.36  E-value: 1.24e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 296431537    1 MRLEEMIFLNYNKLNETDLLIWKYITANKKHCSKMSINELAMKCNVSRATITRFVKKLDLKGFSEFKVLLSWE 73
Cdd:pfam01418   1 MGLLEKIQSRYSKLTKSERKIADYILAHPDLAIHLSISAIAKAAGVSEATIVRFCQKLGFSGFPELKLALAGE 73
SIS pfam01380
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 110-243 2.10e-14

SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Presumably the SIS domains bind to the end-product of the pathway.


Pssm-ID: 426230 [Multi-domain]  Cd Length: 131  Bit Score: 68.09  E-value: 2.10e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296431537  110 LLYESRTIYAYGSGDIQNVvAKQIKRMFLSCQEIIYDFE-GRTFDDSFYNIVSKNDVMIIISLSGENENTLNIARRLKLI 188
Cdd:pfam01380   1 LLAKAKRIFVIGRGTSYAI-ALELALKFEEIGYKVVEVElASELRHGVLALVDEDDLVIAISYSGETKDLLAAAELAKAR 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 296431537  189 GTKIISITEFKNNTLTDLSDESIYISATNISFLqmhPSYKLTMLYFILIELLFIK 243
Cdd:pfam01380  80 GAKIIAITDSPGSPLAREADHVLYINAGPETGV---ASTKSITAQLAALDALAVA 131
PRK11337 PRK11337
MurR/RpiR family transcriptional regulator;
1-208 7.36e-12

MurR/RpiR family transcriptional regulator;


Pssm-ID: 183089 [Multi-domain]  Cd Length: 292  Bit Score: 64.01  E-value: 7.36e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296431537   1 MRLEEMIFLnynklnETDLLIWkyITANKKHCSKMSINELAMKCNVSRATITRFVKKLDLKGFSEFKVLLS-WESEKVHV 79
Cdd:PRK11337  21 MKQEGLTPL------ESRVVEW--LLKPGDLSEATALKDIAEALAVSEAMIVKVAKKLGFSGFRNLRSALEdYFSQSEQV 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296431537  80 IENQ-SFDIACNSIIKYV---------EDQKNKDYDAL---CKLLYESRTIYAYGSGDiQNVVAKQIKRMFL----SCQe 142
Cdd:PRK11337  93 LHSElSFDDAPQDVVNKVfntslqaieETQSILDVDEFhraARFFYQARQRDLYGAGG-SAAIARDVQHKFLrigvRCQ- 170

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 296431537 143 iiydfegrTFDDSFYNIVS-----KNDVMIIISLSGENENTLNIARRLKLIGTKIISITEFKNNTLTDLSD 208
Cdd:PRK11337 171 --------AYDDAHIMLMSaallqEGDVVLVVSHSGRTSDVIEAVELAKKNGAKIICITNSYHSPIAKLAD 233
PRK14101 PRK14101
bifunctional transcriptional regulator/glucokinase;
36-246 4.54e-09

bifunctional transcriptional regulator/glucokinase;


Pssm-ID: 184507 [Multi-domain]  Cd Length: 638  Bit Score: 56.46  E-value: 4.54e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296431537  36 SINELAMKCNVSRATITRFVKKLDLKGFSEFKVLLS--------WESEKVHVIENQS------FDIACNSIIKYVEDQKN 101
Cdd:PRK14101 376 PIVDIARKADVSQPTVIRFCRSLGCQGLSDFKLKLAtgltgtipMSHSQVHLGDTATdfgakvLDNTVSAILQLREHLNF 455

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296431537 102 KDYDALCKLLYESRTIYAYGSGDiQNVVAKQIKRMF--LSCQEIIYdfegrtfDDSFYNIVS-----KNDVMIIISLSGE 174
Cdd:PRK14101 456 EHVEQAIDILNNARRIEFYGLGN-SNIVAQDAHYKFfrFGIPTIAY-------GDLYMQAASaallgKGDVIVAVSKSGR 527

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 296431537 175 NENTLNIARRLKLIGTKIISITEfKNNTLTDLSDesIYISATNISFLQMHPSYKLTMLYFILIELLFIKYSI 246
Cdd:PRK14101 528 APELLRVLDVAMQAGAKVIAITS-SNTPLAKRAT--VALETDHIEMRESQLSMISRILHLVMIDILAVGVAI 596
SIS_Kpsf cd05014
KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ...
 159-208 8.84e-09

KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-phosphate to arabinose 5-phosphate. This is the second step in the CMP-Kdo biosynthesis pathway.


Pssm-ID: 240145 [Multi-domain]  Cd Length: 128  Bit Score: 52.54  E-value: 8.84e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 296431537 159 IVSKNDVMIIISLSGENENTLNIARRLKLIGTKIISITEFKNNTLTDLSD 208
Cdd:cd05014   44 MVTPGDVVIAISNSGETDELLNLLPHLKRRGAPIIAITGNPNSTLAKLSD 93
SIS_PHI cd05005
Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) ...
 160-215 2.96e-08

Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with formadelhyde to become hexulose-6-phosphate, which is then isomerized to fructose-6-phosphate by PHI.


Pssm-ID: 240138 [Multi-domain]  Cd Length: 179  Bit Score: 52.19  E-value: 2.96e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 296431537 160 VSKNDVMIIISLSGENENTLNIARRLKLIGTKIISITEFKNNTLTDLSDESIYISA 215
Cdd:cd05005   73 IGPGDLLIAISGSGETSSVVNAAEKAKKAGAKVVLITSNPDSPLAKLADVVVVIPA 128
GutQ COG0794
D-arabinose 5-phosphate isomerase GutQ [Carbohydrate transport and metabolism, Cell wall ...
 159-214 1.78e-06

D-arabinose 5-phosphate isomerase GutQ [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440557 [Multi-domain]  Cd Length: 317  Bit Score: 48.05  E-value: 1.78e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 296431537 159 IVSKNDVMIIISLSGENENTLNIARRLKLIGTKIISITEFKNNTLTDLSDESIYIS 214
Cdd:COG0794   88 MITPGDVVIAISNSGETEELLALLPLLKRLGVPLIAITGNPDSTLARAADVVLDLP 143
PRK11302 PRK11302
DNA-binding transcriptional regulator HexR; Provisional
 1-196 5.08e-05

DNA-binding transcriptional regulator HexR; Provisional


Pssm-ID: 183082 [Multi-domain]  Cd Length: 284  Bit Score: 43.44  E-value: 5.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296431537   1 MRLEEMIFLNYNKLNETDLLIWKYITANKKHCSKMSINELAMKCNVSRATITRFVKKLDLKGFSEFKVLLS--------W 72
Cdd:PRK11302   1 MNMLEKIQSRLEHLSKSERKVAEVILASPQTAIHSSIATLAKMANVSEPTVNRFCRSLDTKGFPDFKLHLAqslangtpY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296431537  73 ESEkvHVIENQS---------------FDIACNSI-IKYVedqkNKDYDalckLLYESRTIYAYGSGDIQNVVAKQIKRM 136
Cdd:PRK11302  81 VNR--NVEEDDSveaytgkifesamasLDHARQSLdPSAI----NRAVD----LLTQAKKISFFGLGASAAVAHDAQNKF 150

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 296431537 137 FLSCQEIIYdfegrtFDDsfynIV---------SKNDVMIIISLSGENENTLNIARRLKLIGTKIISIT 196
Cdd:PRK11302 151 FRFNVPVVY------FDD----IVmqrmscmnsSDGDVVVLISHTGRTKSLVELAQLARENGATVIAIT 209
SIS_GlmS_GlmD_1 cd05008
SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and ...
 158-215 1.43e-04

SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal glutaminase domain and two C-terminal SIS domains and catalyzes the first step in hexosamine metabolism, converting fructose 6-phosphate into glucosamine 6-phosphate using glutamine as nitrogen source. The glutaminase domain hydrolyzes glutamine to glutamate and ammonia. Ammonia is transferred through a channel to the isomerase domain for glucosamine 6-phosphate synthesis. The end product of the pathway is N-acetylglucosamine, which plays multiple roles in eukaryotic cells including being a building block of bacterial and fungal cell walls. In the absence of glutamine, GlmS catalyzes the isomerization of fructose 6-phosphate into glucose 6- phosphate (PGI-like activity). Glucosamine-6-phosphate deaminase (GlmD) contains two SIS domains and catalyzes the deamination and isomerization of glucosamine-6-phosphate into fructose-6-phosphate with the release of ammonia; in presence of high ammonia concentration, GlmD can catalyze the reverse reaction.


Pssm-ID: 240141 [Multi-domain]  Cd Length: 126  Bit Score: 40.56  E-value: 1.43e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 296431537 158 NIVSKNDVMIIISLSGENENTLNIARRLKLIGTKIISITEFKNNTLTDLSDESIYISA 215
Cdd:cd05008   42 PLLDEDTLVIAISQSGETADTLAALRLAKEKGAKTVAITNVVGSTLAREADYVLYLRA 99
COG3355 COG3355
Predicted transcriptional regulator [Transcription];
14-63 2.85e-04

Predicted transcriptional regulator [Transcription];


Pssm-ID: 442583 [Multi-domain]  Cd Length: 131  Bit Score: 39.95  E-value: 2.85e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 296431537  14 LNETDLLIWKYITANKKhcsKMSINELAMKCNVSRATITRFVKKLDLKGF 63
Cdd:COG3355   25 LSETDAEVYLILLENGE---PLTVEELAEALDRSRSTVYRSLQKLLEAGL 71
PRK11557 PRK11557
MurR/RpiR family transcriptional regulator;
11-235 3.52e-04

MurR/RpiR family transcriptional regulator;


Pssm-ID: 183195 [Multi-domain]  Cd Length: 278  Bit Score: 40.90  E-value: 3.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296431537  11 YNKLNETDLLIWKYITANKKHCSKMSINELAMKCNVSRATITRFVKKLDLKGFSEFKVLLSwesekVHVIENQSFDIACn 90
Cdd:PRK11557   7 YPGLAQSDRKLADYLLLQPDTARHLSSQQLANEAGVSQSSVVKFAQKLGYKGFPALKLALS-----EALASQPEPPSVP- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296431537  91 siikyVEDQKNKDyDALC----KLLYEsRTIYAYGSGDIqNVVAK--QIKRMFLSCQEIIY-----------DFEGRTFD 153
Cdd:PRK11557  81 -----VHNQIRGD-DPLRlvgeKLIKE-NTAAMRATLDV-NSEEKlhECVTMLRSARRIILtgigasglvaqNFAWKLMK 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296431537 154 DSFYNIV--------------SKNDVMIIISLSGENENTLNIARRLKLIGTKIISITEFKNNTLTDLSDESIY------- 212
Cdd:PRK11557 153 IGINAVAerdmhallatvqalSPDDLLLAISYSGERRELNLAADEALRVGAKVLAITGFTPNALQQRASHCLYtiaeeqa 232

                        250       260
                 ....*....|....*....|...
gi 296431537 213 ISATNISflQMHPSYKLTMLYFI 235
Cdd:PRK11557 233 TRSAAIS--STHAQGMLTDLLFM 253
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
35-63 1.01e-03

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 37.57  E-value: 1.01e-03
                           10        20
                   ....*....|....*....|....*....
gi 296431537    35 MSINELAMKCNVSRATITRFVKKLDLKGF 63
Cdd:smart00347  25 LSVSELAKRLGVSPSTVTRVLDRLEKKGL 53
SIS_1 cd05710
A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar ...
 160-212 1.16e-03

A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.


Pssm-ID: 240214 [Multi-domain]  Cd Length: 120  Bit Score: 37.94  E-value: 1.16e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 296431537 160 VSKNDVMIIISLSGENENTLNIARRLKLIGTKIISITEFKNNTLTDLSDESIY 212
Cdd:cd05710   45 LTEKSVVILASHSGNTKETVAAAKFAKEKGATVIGLTDDEDSPLAKLADYVIV 97
SIS_2 pfam13580
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 160-196 1.99e-03

SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.


Pssm-ID: 433326 [Multi-domain]  Cd Length: 138  Bit Score: 37.57  E-value: 1.99e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 296431537  160 VSKNDVMIIISLSGENENTLNIARRLKLIGTKIISIT 196
Cdd:pfam13580 101 GRPGDVLIVISNSGINAVPVEAALEAKERGMKVIALT 137
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 35-63 4.89e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 34.45  E-value: 4.89e-03
                          10        20
                  ....*....|....*....|....*....
gi 296431537   35 MSINELAMKCNVSRATITRFVKKLDLKGF 63
Cdd:pfam01047  18 LTVSELAEKLGVSKSTVTRVLDRLEKKGL 46
PRK00331 PRK00331
isomerizing glutamine--fructose-6-phosphate transaminase;
159-215 7.73e-03

isomerizing glutamine--fructose-6-phosphate transaminase;


Pssm-ID: 234729 [Multi-domain]  Cd Length: 604  Bit Score: 37.33  E-value: 7.73e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 296431537 159 IVSKNDVMIIISLSGENENTLNIARRLKLIGTKIISITEFKNNTLTDLSDESIYISA 215
Cdd:PRK00331 333 VLSPKTLVIAISQSGETADTLAALRLAKELGAKTLAICNVPGSTIARESDAVLYTHA 389
PRK02947 PRK02947
sugar isomerase domain-containing protein;
160-196 8.84e-03

sugar isomerase domain-containing protein;


Pssm-ID: 179510 [Multi-domain]  Cd Length: 246  Bit Score: 36.77  E-value: 8.84e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 296431537 160 VSKNDVMIIISLSGENENTLNIARRLKLIGTKIISIT 196
Cdd:PRK02947 104 IRPGDVLIVVSNSGRNPVPIEMALEAKERGAKVIAVT 140
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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