NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|302861101|gb|EFL84175|]
View 

hypothetical protein HMPREF0189_02318 [Burkholderiales bacterium 1_1_47]

Protein Classification

nucleotidyl transferase AbiEii/AbiGii toxin family protein( domain architecture ID 10556042)

nucleotidyl transferase family protein similar to abortive infection proteins AbiEii/AbiGii

PubMed:  19833706

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
AbiEii pfam08843
Nucleotidyl transferase AbiEii toxin, Type IV TA system; This family was recently identified ...
 30-181 4.17e-18

Nucleotidyl transferase AbiEii toxin, Type IV TA system; This family was recently identified as belonging to the nucleotidyltransferase superfamily. AbiEii is the cognate toxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.


:

Pssm-ID: 430254  Cd Length: 239  Bit Score: 79.94  E-value: 4.17e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302861101   30 DQFVLKGGTALSLCYGL-DRFSEDIDL-------DGRKQDIKEIVKRFCVNHGVNFRVAKDTATVKRCIIDY-------- 93
Cdd:pfam08843  13 DKFVFKGGTALSLWYGLiPRFSEDIDFtlpagdrDESLEALEEALREIAAALVEDGVVVELAESIEKLEDRYgglrlryp 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302861101   94 ----GNDVHPLKIEVSYRNKNLGLEEAS--KDWTQIHG---IKVYGIDALARMKAMAY----QGRDKIRDLYDLSFIVNN 160
Cdd:pfam08843  93 aelgGGPRQRIKIDIGFRDAVPPPERRPlpPLLEELGPafeVPVYSLEELLAEKLLALldrgRDRSRARDLYDLYLLLRH 172

                         170       180
                  ....*....|....*....|.
gi 302861101  161 FSDGLSHQTkgMIRDTLSYKG 181
Cdd:pfam08843 173 ELDAALLAE--ALRATFARRG 191
 
Name Accession Description Interval E-value
AbiEii pfam08843
Nucleotidyl transferase AbiEii toxin, Type IV TA system; This family was recently identified ...
 30-181 4.17e-18

Nucleotidyl transferase AbiEii toxin, Type IV TA system; This family was recently identified as belonging to the nucleotidyltransferase superfamily. AbiEii is the cognate toxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.


Pssm-ID: 430254  Cd Length: 239  Bit Score: 79.94  E-value: 4.17e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302861101   30 DQFVLKGGTALSLCYGL-DRFSEDIDL-------DGRKQDIKEIVKRFCVNHGVNFRVAKDTATVKRCIIDY-------- 93
Cdd:pfam08843  13 DKFVFKGGTALSLWYGLiPRFSEDIDFtlpagdrDESLEALEEALREIAAALVEDGVVVELAESIEKLEDRYgglrlryp 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302861101   94 ----GNDVHPLKIEVSYRNKNLGLEEAS--KDWTQIHG---IKVYGIDALARMKAMAY----QGRDKIRDLYDLSFIVNN 160
Cdd:pfam08843  93 aelgGGPRQRIKIDIGFRDAVPPPERRPlpPLLEELGPafeVPVYSLEELLAEKLLALldrgRDRSRARDLYDLYLLLRH 172

                         170       180
                  ....*....|....*....|.
gi 302861101  161 FSDGLSHQTkgMIRDTLSYKG 181
Cdd:pfam08843 173 ELDAALLAE--ALRATFARRG 191
COG2253 COG2253
Predicted nucleotidyltransferase component of viral defense system [Defense mechanisms];
7-163 5.37e-18

Predicted nucleotidyltransferase component of viral defense system [Defense mechanisms];


Pssm-ID: 441854  Cd Length: 256  Bit Score: 80.10  E-value: 5.37e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302861101   7 EKDWqtnhgnFIEAFLLFLNKQT--DQFVLKGGTALSLCYG-LDRFSEDIDLDGR-----KQDIKEI---VKRFCVNHGV 75
Cdd:COG2253   23 EKDY------LLERILPALSKSPlaDKLVFKGGTALRKFYGdLPRFSEDLDFTLLgdflsLEEIKKLleeIEEALEGEGL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302861101  76 NFRVA--KDTATVKRCIIDY----GNDVHPLKIEVSYRNKNLgLEEASKDWTQI--------HGIKVYGIDALARMKAMA 141
Cdd:COG2253   97 EVEIKepKEEGDYDRIRIRYpgalGGARQRIKIEINTRERVV-LPPEERPLPPLyedlddppFEIRVYSLEELLAEKLRA 175

                        170       180
                 ....*....|....*....|..
gi 302861101 142 YQGRDKIRDLYDLSFIVNNFSD 163
Cdd:COG2253  176 LLDRSRPRDLYDLWYLLRQEGD 197
 
Name Accession Description Interval E-value
AbiEii pfam08843
Nucleotidyl transferase AbiEii toxin, Type IV TA system; This family was recently identified ...
 30-181 4.17e-18

Nucleotidyl transferase AbiEii toxin, Type IV TA system; This family was recently identified as belonging to the nucleotidyltransferase superfamily. AbiEii is the cognate toxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.


Pssm-ID: 430254  Cd Length: 239  Bit Score: 79.94  E-value: 4.17e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302861101   30 DQFVLKGGTALSLCYGL-DRFSEDIDL-------DGRKQDIKEIVKRFCVNHGVNFRVAKDTATVKRCIIDY-------- 93
Cdd:pfam08843  13 DKFVFKGGTALSLWYGLiPRFSEDIDFtlpagdrDESLEALEEALREIAAALVEDGVVVELAESIEKLEDRYgglrlryp 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302861101   94 ----GNDVHPLKIEVSYRNKNLGLEEAS--KDWTQIHG---IKVYGIDALARMKAMAY----QGRDKIRDLYDLSFIVNN 160
Cdd:pfam08843  93 aelgGGPRQRIKIDIGFRDAVPPPERRPlpPLLEELGPafeVPVYSLEELLAEKLLALldrgRDRSRARDLYDLYLLLRH 172

                         170       180
                  ....*....|....*....|.
gi 302861101  161 FSDGLSHQTkgMIRDTLSYKG 181
Cdd:pfam08843 173 ELDAALLAE--ALRATFARRG 191
COG2253 COG2253
Predicted nucleotidyltransferase component of viral defense system [Defense mechanisms];
7-163 5.37e-18

Predicted nucleotidyltransferase component of viral defense system [Defense mechanisms];


Pssm-ID: 441854  Cd Length: 256  Bit Score: 80.10  E-value: 5.37e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302861101   7 EKDWqtnhgnFIEAFLLFLNKQT--DQFVLKGGTALSLCYG-LDRFSEDIDLDGR-----KQDIKEI---VKRFCVNHGV 75
Cdd:COG2253   23 EKDY------LLERILPALSKSPlaDKLVFKGGTALRKFYGdLPRFSEDLDFTLLgdflsLEEIKKLleeIEEALEGEGL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302861101  76 NFRVA--KDTATVKRCIIDY----GNDVHPLKIEVSYRNKNLgLEEASKDWTQI--------HGIKVYGIDALARMKAMA 141
Cdd:COG2253   97 EVEIKepKEEGDYDRIRIRYpgalGGARQRIKIEINTRERVV-LPPEERPLPPLyedlddppFEIRVYSLEELLAEKLRA 175

                        170       180
                 ....*....|....*....|..
gi 302861101 142 YQGRDKIRDLYDLSFIVNNFSD 163
Cdd:COG2253  176 LLDRSRPRDLYDLWYLLRQEGD 197
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH