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Conserved domains on  [gi|307615086|gb|EFN94299|]
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ABC transporter, permease protein [Mobiluncus mulieris FB024-16]

Protein Classification

carbohydrate ABC transporter permease( domain architecture ID 10003067)

carbohydrate ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter responsible for the translocation across the membrane of one or more from a variety of carbohydrate substrates including trehalose, lactose, arabinose, and maltodextrin

Gene Ontology:  GO:0042626|GO:0140359|GO:0008643|GO:0055085
PubMed:  25750732|24638992|30626703
TCDB:  3.A.1.1.-

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
6-296 1.44e-71

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


:

Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 222.70  E-value: 1.44e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086   6 TQKLHRKKDGLWATLFVGPHAILFVLFFLIPVVYGVYVSFTKWSLFNDPM-WIGFKNYQELFFDresifhDQLIYGMSST 84
Cdd:COG1175    8 AARRRRRRRRLAAYLFLLPALLLLLVFVLYPLLYTLYLSFTDWNLLGPPPeFVGLDNYARLFTD------PRFWNALGNT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086  85 LIFVLFTVPLCILVPLFAAGMLLTQNKLRKVFQAIFYIPSMFAVSAVMLIFSFLLSKSYGPLQ---GWFHVD-VNVTQTQ 160
Cdd:COG1175   82 LLFTVVSVPLQLVLGLLLALLLNRKLRGRGFFRTLFFLPWVISPVVVALIWKWLFNPDYGLLNallGALGLEpINWLGDP 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086 161 PYAWIALVLVTVWWCIGQNLIIYIAALAGVPRDQIDAARIDGASNWRILRQIQLPNIQLPMIFTIITTTVLQFNVYGQPL 240
Cdd:COG1175  162 SLALPAVIIVTVWKGTGFNMLIFLAGLQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQVFDLVY 241

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 307615086 241 MLTNGGPNNSTKVLLMSIQQNAFGSGipAAGMASAQATILGATIIIVSAIELLILK 296
Cdd:COG1175  242 VLTGGGPGNSTTTLVLYIYQTAFQQF--DFGYASAIAVVLFLIILVLTLLQLRLLR 295
 
Name Accession Description Interval E-value
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
6-296 1.44e-71

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 222.70  E-value: 1.44e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086   6 TQKLHRKKDGLWATLFVGPHAILFVLFFLIPVVYGVYVSFTKWSLFNDPM-WIGFKNYQELFFDresifhDQLIYGMSST 84
Cdd:COG1175    8 AARRRRRRRRLAAYLFLLPALLLLLVFVLYPLLYTLYLSFTDWNLLGPPPeFVGLDNYARLFTD------PRFWNALGNT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086  85 LIFVLFTVPLCILVPLFAAGMLLTQNKLRKVFQAIFYIPSMFAVSAVMLIFSFLLSKSYGPLQ---GWFHVD-VNVTQTQ 160
Cdd:COG1175   82 LLFTVVSVPLQLVLGLLLALLLNRKLRGRGFFRTLFFLPWVISPVVVALIWKWLFNPDYGLLNallGALGLEpINWLGDP 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086 161 PYAWIALVLVTVWWCIGQNLIIYIAALAGVPRDQIDAARIDGASNWRILRQIQLPNIQLPMIFTIITTTVLQFNVYGQPL 240
Cdd:COG1175  162 SLALPAVIIVTVWKGTGFNMLIFLAGLQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQVFDLVY 241

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 307615086 241 MLTNGGPNNSTKVLLMSIQQNAFGSGipAAGMASAQATILGATIIIVSAIELLILK 296
Cdd:COG1175  242 VLTGGGPGNSTTTLVLYIYQTAFQQF--DFGYASAIAVVLFLIILVLTLLQLRLLR 295
PRK10561 PRK10561
sn-glycerol-3-phosphate ABC transporter permease UgpA;
20-292 2.82e-13

sn-glycerol-3-phosphate ABC transporter permease UgpA;


Pssm-ID: 182550 [Multi-domain]  Cd Length: 280  Bit Score: 68.70  E-value: 2.82e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086  20 LFVGPHAILFVLFFLIPVVYGVYVSFTKWSLFN-DPMWIGFKNYQELFFDresifhDQLIYGMSSTLIFVLFTVPLCILV 98
Cdd:PRK10561   1 LLVAPQLIITVIFFIWPAGEALWYSLQSVDPFGfSSQFVGLDNFVALFHD------SYYLDSFWTTIKFSTLVTVSGLLV 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086  99 PLFAAGMLLTQNKLRKVFQAIFYIPSMFAVSAVMLIFSFLLSKSYGPLQ---GWFHVDVNVTQTQPYAWIALVLVTVWWC 175
Cdd:PRK10561  75 SLFFAALVDYVVRGSRFYQTLMLLPYAVAPAVAAVLWIFLFNPGRGLIThflAEFGYDWNHAQNSGQAMFLVVFASVWKQ 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086 176 IGQNLIIYIAALAGVPRDQIDAARIDGASNWRILRQIQLPNIQLPMIFTIITTTVLQ-FNVYGQPLMLTNGGPNNSTKVL 254
Cdd:PRK10561 155 ISYNFLFFFAALQSIPRSLVEAAAIDGAGPIRRFFKLALPLIAPVSFFLLVVNLVYAfFDTFPVIDAATSGGPVQATTTL 234

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 307615086 255 LMSIQQNAFgSGIPAAGMAsAQATILGATIIIVSAIEL 292
Cdd:PRK10561 235 IYKIYREGF-TGLDLSSSA-AQSVVLMFLVIVLTVVQF 270
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 84-285 4.30e-11

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 60.76  E-value: 4.30e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086  84 TLIFVLFTVPLCILVPLFAAGML-LTQNKLRKVFQAIFYIPSMFAVSAVMLIFSFLLSKSYGPLQGWFhvdvnvtqtqpY 162
Cdd:cd06261    4 TLLLALIATLLALVLGLLLGIILaRKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPG-----------L 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086 163 AWIALVLVTVWWcIGQNLIIYIAALAGVPRDQIDAARIDGASNWRILRQIQLPNIQLPMIFTIITTTVLQFNVYGQPLML 242
Cdd:cd06261   73 GLPALILALLLI-APFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFL 151

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 307615086 243 TNGGPnnstKVLLMSIQQNAFGSGIPAAGMASAQATILGATII 285
Cdd:cd06261  152 GGGEA----PGPGTGLLLIFAILFPGDLGVAAAVALILLLLSL 190
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 111-290 1.90e-07

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 50.38  E-value: 1.90e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086  111 KLRKVFQAIFYIPSMFAVSAVMLIFSFLlsksygPLQGWFHvdvnvtqtqpYAWIALVLVTVWWCIGQNLIIYIAALAGV 190
Cdd:pfam00528  15 RLDRLLRPLIDLLQALPSFVLAILLVVI------AILSILG----------HGILPAIILALLGWAGYARLIRRAALRSL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086  191 PRDQIDAARIDGASNWRILRQIQLPNIQLPMIFTIITTTVLQFNVYGQPLMLTNGGPNNSTKVLLMSIQQNAFGSGipaa 270
Cdd:pfam00528  79 PSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGLGLLLIEAILGYDYPEIQG---- 154

                         170       180
                  ....*....|....*....|
gi 307615086  271 gmASAQATILGATIIIVSAI 290
Cdd:pfam00528 155 --PVLAAALILLLLNLLVDI 172
PhnU2 TIGR03262
putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding ...
 18-266 1.02e-06

putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 274495 [Multi-domain]  Cd Length: 546  Bit Score: 49.68  E-value: 1.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086   18 ATLFVGPHAILFVLFFLIPVVygvyVSFTKWSLFNDPMWIGFKNYQELFfdRESIFHDQLIYGMSSTLIFVLFTVPLCIL 97
Cdd:TIGR03262   3 ARLLLAGMILALLLFLLLPLL----ALLTKSVYDSDGDFIGLANFAEYF--ATPGLLQSLGNSLTVSAIVTAIVVPLAFA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086   98 vplFAAGMLLTQNKLRKVFQAIFYIPsMFA---VSAVMLIFSFllsKSYGPLQGWFHvDVNVtqtqpYAWIALVLVTVWW 174
Cdd:TIGR03262  77 ---FAYALTRSRIPGKGAFRLVALLP-LLApslLPAISLIYLF---GNQGLLKGLLG-GFSI-----YGFWGIVIGEVFY 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086  175 CIGQNLIIYIAALAGVPRDQIDAARIDGASNWRILRQIQLPNIQLPMIFTIITTTVLQFNVYGQPLMLTNGGPNNSTKVL 254
Cdd:TIGR03262 144 TFPHALMILVTALSLADGRLYEAARAMGASPWRTFFTVTLPGAKYGLISAAFVVFTLVITDFGVPKVIGGDYNVLATDIY 223

                         250
                  ....*....|..
gi 307615086  255 LMSIQQNAFGSG 266
Cdd:TIGR03262 224 KQVIGQQNFPMG 235
 
Name Accession Description Interval E-value
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
6-296 1.44e-71

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 222.70  E-value: 1.44e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086   6 TQKLHRKKDGLWATLFVGPHAILFVLFFLIPVVYGVYVSFTKWSLFNDPM-WIGFKNYQELFFDresifhDQLIYGMSST 84
Cdd:COG1175    8 AARRRRRRRRLAAYLFLLPALLLLLVFVLYPLLYTLYLSFTDWNLLGPPPeFVGLDNYARLFTD------PRFWNALGNT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086  85 LIFVLFTVPLCILVPLFAAGMLLTQNKLRKVFQAIFYIPSMFAVSAVMLIFSFLLSKSYGPLQ---GWFHVD-VNVTQTQ 160
Cdd:COG1175   82 LLFTVVSVPLQLVLGLLLALLLNRKLRGRGFFRTLFFLPWVISPVVVALIWKWLFNPDYGLLNallGALGLEpINWLGDP 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086 161 PYAWIALVLVTVWWCIGQNLIIYIAALAGVPRDQIDAARIDGASNWRILRQIQLPNIQLPMIFTIITTTVLQFNVYGQPL 240
Cdd:COG1175  162 SLALPAVIIVTVWKGTGFNMLIFLAGLQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQVFDLVY 241

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 307615086 241 MLTNGGPNNSTKVLLMSIQQNAFGSGipAAGMASAQATILGATIIIVSAIELLILK 296
Cdd:COG1175  242 VLTGGGPGNSTTTLVLYIYQTAFQQF--DFGYASAIAVVLFLIILVLTLLQLRLLR 295
LplB COG4209
ABC-type polysaccharide transport system, permease component [Carbohydrate transport and ...
 4-272 5.55e-22

ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 443357 [Multi-domain]  Cd Length: 316  Bit Score: 93.62  E-value: 5.55e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086   4 KNTQKLHRKKDGLWATLFVGPHAILFVLFFLIPVvYGVYVSFTKWS----LFNDPmWIGFKNYQELFFDresifhDQLIY 79
Cdd:COG4209   15 RKKSFLKRLKRDWQLYLMLLPGLIYLLIFSYLPM-YGIVIAFKDYNpfkgIFGSP-WVGLKNFKFLFSS------PDFWR 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086  80 GMSSTLIFVLFTVPLCILVPLFAAGML--LTQNKLRKVFQAIFYIP---SMFAVSAVMLIFsflLSKSYGPLQ---GWFH 151
Cdd:COG4209   87 VLRNTLLISLLKLVFGFPLPIILALLLneLRSKRFKKTVQTISYLPhflSWVVVAGIVYQF---LSPDTGLVNqllRALG 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086 152 VD-VNVTQTQPYAWIALVLVTVWWCIGQNLIIYIAALAGVPRDQIDAARIDGASNWRILRQIQLPNIqLPmifTIITTTV 230
Cdd:COG4209  164 GEpINFLTEPKYFRPIYVFSGIWKEAGWGSIIYLAAITGIDPELYEAAAIDGAGRWQQIWHITLPGI-RP---TIVILLI 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 307615086 231 LQ----FNV-YGQPLMLTNGGPNN-----STKVLLMSIQQNAFGSGIpAAGM 272
Cdd:COG4209  240 LNigniLNVgFEQIYLLYNPLNYStsdviDTYVYRIGLQNGDYSYAT-AVGL 290
PRK10561 PRK10561
sn-glycerol-3-phosphate ABC transporter permease UgpA;
20-292 2.82e-13

sn-glycerol-3-phosphate ABC transporter permease UgpA;


Pssm-ID: 182550 [Multi-domain]  Cd Length: 280  Bit Score: 68.70  E-value: 2.82e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086  20 LFVGPHAILFVLFFLIPVVYGVYVSFTKWSLFN-DPMWIGFKNYQELFFDresifhDQLIYGMSSTLIFVLFTVPLCILV 98
Cdd:PRK10561   1 LLVAPQLIITVIFFIWPAGEALWYSLQSVDPFGfSSQFVGLDNFVALFHD------SYYLDSFWTTIKFSTLVTVSGLLV 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086  99 PLFAAGMLLTQNKLRKVFQAIFYIPSMFAVSAVMLIFSFLLSKSYGPLQ---GWFHVDVNVTQTQPYAWIALVLVTVWWC 175
Cdd:PRK10561  75 SLFFAALVDYVVRGSRFYQTLMLLPYAVAPAVAAVLWIFLFNPGRGLIThflAEFGYDWNHAQNSGQAMFLVVFASVWKQ 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086 176 IGQNLIIYIAALAGVPRDQIDAARIDGASNWRILRQIQLPNIQLPMIFTIITTTVLQ-FNVYGQPLMLTNGGPNNSTKVL 254
Cdd:PRK10561 155 ISYNFLFFFAALQSIPRSLVEAAAIDGAGPIRRFFKLALPLIAPVSFFLLVVNLVYAfFDTFPVIDAATSGGPVQATTTL 234

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 307615086 255 LMSIQQNAFgSGIPAAGMAsAQATILGATIIIVSAIEL 292
Cdd:PRK10561 235 IYKIYREGF-TGLDLSSSA-AQSVVLMFLVIVLTVVQF 270
PotB COG1176
ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport ...
 16-290 2.52e-12

ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism];


Pssm-ID: 440789 [Multi-domain]  Cd Length: 287  Bit Score: 65.94  E-value: 2.52e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086  16 LWATLFVGPHAILFVLFFLIPVVYGVYVSFTKWSLFNDPMW-IGFKNYQELFFDreSIFHDQLIYgmssTLIFVLFTVPL 94
Cdd:COG1176    9 LRPLLLLLPALLWLLLFFVLPLLLLLVYSFTTRDPYGGVVPgFTLENYARLFTD--PLYLKVLLR----TLWIALLTTLI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086  95 CILV--PLfAAGMLLTQNKLRKVFQAIFYIPsmFAVSAVMLIFSF--LLSKSyGPLQ------GWFHVDVNVTQTQPYAW 164
Cdd:COG1176   83 CLLLgyPI-AYFLARAPPRWRNLLLLLVILP--FWTSFLVRTYAWivLLGRN-GLLNslllalGLIDEPLRLLYTEFAVV 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086 165 IALVLVTVWWCIgqnLIIYiAALAGVPRDQIDAARIDGASNWRILRQIQLPNIqLPMIFT-IITTTVLQFNVYGQPLMLt 243
Cdd:COG1176  159 IGLVYVYLPFMV---LPLY-AALEKIDPSLLEAARDLGASPWQTFRRVILPLS-LPGIIAgSLLVFIPALGAFVTPALL- 232

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 307615086 244 nGGPNnsTKVLLMSIQQNAFGSGipAAGMASAQATILGATIIIVSAI 290
Cdd:COG1176  233 -GGGK--VLMIGNLIYQQFLSAL--NWPLAAALAVVLLLIVLLVLLL 274
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 84-285 4.30e-11

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 60.76  E-value: 4.30e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086  84 TLIFVLFTVPLCILVPLFAAGML-LTQNKLRKVFQAIFYIPSMFAVSAVMLIFSFLLSKSYGPLQGWFhvdvnvtqtqpY 162
Cdd:cd06261    4 TLLLALIATLLALVLGLLLGIILaRKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPG-----------L 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086 163 AWIALVLVTVWWcIGQNLIIYIAALAGVPRDQIDAARIDGASNWRILRQIQLPNIQLPMIFTIITTTVLQFNVYGQPLML 242
Cdd:cd06261   73 GLPALILALLLI-APFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFL 151

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 307615086 243 TNGGPnnstKVLLMSIQQNAFGSGIPAAGMASAQATILGATII 285
Cdd:cd06261  152 GGGEA----PGPGTGLLLIFAILFPGDLGVAAAVALILLLLSL 190
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 17-224 8.27e-11

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 61.28  E-value: 8.27e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086  17 WATLFVGPHAILFVLFFLIPVVYGVYVSFTKwSLFNDPMWIGF--KNYQELFFDresifhDQLIYGMSSTLIFVLFTVPL 94
Cdd:COG1177    4 LGRLLLRLFLALVLLFLYLPILVLVLYSFND-SWFLTFPPEGFtlRWYAELFSD------PRLLDALLNSLLIALLSTLL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086  95 CILVPLFAA-GMLLTQNKLRKVFQAIFYIPsmFAVSAVMLIFSFLLsksygplqgwFHVDVNVTQTqpyaWIALVLVTVW 173
Cdd:COG1177   77 ATVLGTPAAlALARYRFRGRRLLLALLLLP--LVVPGIVLGVALLL----------LFSALGLSGG----LWGLILAHVV 140

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 307615086 174 WCIGQNLIIYIAALAGVPRDQIDAARIDGASNWRILRQIQLPNIqLPMIFT 224
Cdd:COG1177  141 FTLPFVVLVVLARLQGFDPSLEEAARDLGASPWQTFRRVTLPLI-APGILA 190
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 3-287 1.34e-10

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 60.88  E-value: 1.34e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086   3 MKNTQKLHRKKDGLWATLFVgphAILFVLFFLIPVVYGVYVSF-TKWSLFNDPMWI-----GFKNYQELFFDresifhDQ 76
Cdd:COG0395    1 MSATARRRRRRLGRILLYLL---LILLALLFLFPLYWMVVTSFkPPAEIFSGPPSLlpsefTLENYRAAFTD------GP 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086  77 LIYGMSSTLIFVLFTVPLCILVPLFAA-GMLLTQNKLRKVFQAIFYIPSMFAVSAVMLIFSFLLSksygplqgwfhvDVN 155
Cdd:COG0395   72 FGRYLLNSLIVAVVSTVLSLLLSSLAAyALARFRFRGRKLLFLLILATLMIPGQVLLIPLYLLFR------------QLG 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086 156 VTQTqpyaWIALVLVTVWWCIGQNLIIYIAALAGVPRDQIDAARIDGASNWRILRQIQLPNIqLPMIFTI-ITTTVLQFN 234
Cdd:COG0395  140 LLNT----YWGLILPYLAFGLPFGIFLLRQFFRSIPRELEEAARIDGASEFRIFWRIVLPLS-KPALATVaIFTFIGAWN 214

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 307615086 235 VYGQPLMLTNggpNNSTKVLLMSIQQnAFGSGIPAAGMASAQATILGATIIIV 287
Cdd:COG0395  215 DFLWPLILLT---SPDLRTLPVGLAS-FQGQYGTDWGLLMAAAVIATLPVLIL 263
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
26-296 1.92e-10

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 61.33  E-value: 1.92e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086  26 AILFVLFFLIPVVYGVYVSFTkwslfndpmwIGFKNYQELFFD---RESIFHdqliygmssTLIFVLFTVPLCILVPLFA 102
Cdd:COG1178   17 ALLLALLVLLPLLALLLRAFT----------DGLANFWALLSDpylWRALGN---------TLLLALLVTLLSLLLGVPL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086 103 A-GMLLTQNKLRKVFQAIFYIPsmFAVSAVMLIFSFL-LSKSYGPLQGWFHVDVNVTQTQPYAWIALVLVTVWWCIGQNL 180
Cdd:COG1178   78 AwLLARTDFPGRRLLRWLLLLP--LALPPYVVALAWIaLFGPNGLLNTLLRALFGLEPPDIYGLGGIILVLVLFNYPYVY 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086 181 IIYIAALAGVPRDQIDAARIDGASNWRILRQIQLPNIQLPMIFTIITTTVLQFNVYGQPLMLtnGGPNNstkVLLMSIQQ 260
Cdd:COG1178  156 LLLRAALRSIDASLEEAARSLGASPWRAFRRVTLPLLRPAIAAGALLVFLLCLADFGTPLVL--GGGYT---TLTTAIYQ 230

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 307615086 261 NAFGSGipAAGMASAQATILGATIIIVSAIELLILK 296
Cdd:COG1178  231 AWLGDF--DLGAAAALALVLLLLVLLLLLLERRLRR 264
malF PRK10999
maltose ABC transporter permease MalF;
56-300 1.33e-09

maltose ABC transporter permease MalF;


Pssm-ID: 236816 [Multi-domain]  Cd Length: 520  Bit Score: 58.82  E-value: 1.33e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086  56 WIGFKNYQELFFDrESI---FHDQLIYgmssTLIFVLFTVPLCilvplFAAGMLLT------QNKLRKVFQAIFYIPsmF 126
Cdd:PRK10999 264 TIGWKNFTRVFTD-EGIqkpFIAIFIW----TVVFSLLTVVLT-----VAVGMVLAclvqweALKGKAVYRVLLILP--Y 331

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086 127 AVSAVM--LIFSFLLSKSYGP----LQGWFHVDVNVTQTQPYAWIALVLVTVWWCIGQNLIIYIAALAGVPRDQIDAARI 200
Cdd:PRK10999 332 AVPSFIsiLIFKGLFNQSFGEinmmLSALFGIKPAWFSDPTLAKTMILIVNTWLGYPYMMILCMGLLKAIPDDLYEASAM 411

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086 201 DGASNWRILRQIQLPNIQLPMIFTIITTTVLQFNVYGQPLMLTNGGPN--NSTKV-----LLMSIQQN-AF-GSGIPAAG 271
Cdd:PRK10999 412 DGAGPFQNFFKITLPLLIKPLTPLMIASFAFNFNNFVLIQLLTNGGPDmiGTTTPagytdLLVSYTYRiAFeGGGGQDFG 491

                        250       260
                 ....*....|....*....|....*....
gi 307615086 272 MASAQATILgatIIIVSAIELLILKLCQR 300
Cdd:PRK10999 492 LAAAIATLI---FLLVGALAILNLKATKM 517
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
11-217 1.55e-07

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 52.47  E-value: 1.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086  11 RKKDGLWATLFVGPHAILFVLFFLIPVVYGVYVSFTKWSLFNdpmwIGFKNYQELFFD---RESIFHdQLIYGMSSTLIF 87
Cdd:COG1178  280 RVKLGRWRWLALALCLLLVLLGLLLPLLALLLWSLTKALDDN----LTLDNYRFVLLDpslLRALLN-SLLLALLAALLA 354

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086  88 VLFTVPLcilvplfAAGMLLTQNKLRKVFQAIFYIPsmFAVSAVMLIFSFLLsksygPLQGWFhvDVNVTQTqpyaWIAL 167
Cdd:COG1178  355 VLLALLL-------AYLVRRRRGRLARLLDRLAMLP--YAVPGIVLGLGLLL-----LFNRPL--PLLLYGT----LAIL 414

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 307615086 168 VLVTVWWCIGQNLIIYIAALAGVPRDQIDAARIDGASNWRILRQIQLPNI 217
Cdd:COG1178  415 VLAYVVRFLPFALRSLEAALAQIDPSLEEAARSLGASPLRTLRRVTLPLL 464
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 111-290 1.90e-07

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 50.38  E-value: 1.90e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086  111 KLRKVFQAIFYIPSMFAVSAVMLIFSFLlsksygPLQGWFHvdvnvtqtqpYAWIALVLVTVWWCIGQNLIIYIAALAGV 190
Cdd:pfam00528  15 RLDRLLRPLIDLLQALPSFVLAILLVVI------AILSILG----------HGILPAIILALLGWAGYARLIRRAALRSL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086  191 PRDQIDAARIDGASNWRILRQIQLPNIQLPMIFTIITTTVLQFNVYGQPLMLTNGGPNNSTKVLLMSIQQNAFGSGipaa 270
Cdd:pfam00528  79 PSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGLGLLLIEAILGYDYPEIQG---- 154

                         170       180
                  ....*....|....*....|
gi 307615086  271 gmASAQATILGATIIIVSAI 290
Cdd:pfam00528 155 --PVLAAALILLLLNLLVDI 172
PhnU2 TIGR03262
putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding ...
 18-266 1.02e-06

putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 274495 [Multi-domain]  Cd Length: 546  Bit Score: 49.68  E-value: 1.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086   18 ATLFVGPHAILFVLFFLIPVVygvyVSFTKWSLFNDPMWIGFKNYQELFfdRESIFHDQLIYGMSSTLIFVLFTVPLCIL 97
Cdd:TIGR03262   3 ARLLLAGMILALLLFLLLPLL----ALLTKSVYDSDGDFIGLANFAEYF--ATPGLLQSLGNSLTVSAIVTAIVVPLAFA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086   98 vplFAAGMLLTQNKLRKVFQAIFYIPsMFA---VSAVMLIFSFllsKSYGPLQGWFHvDVNVtqtqpYAWIALVLVTVWW 174
Cdd:TIGR03262  77 ---FAYALTRSRIPGKGAFRLVALLP-LLApslLPAISLIYLF---GNQGLLKGLLG-GFSI-----YGFWGIVIGEVFY 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086  175 CIGQNLIIYIAALAGVPRDQIDAARIDGASNWRILRQIQLPNIQLPMIFTIITTTVLQFNVYGQPLMLTNGGPNNSTKVL 254
Cdd:TIGR03262 144 TFPHALMILVTALSLADGRLYEAARAMGASPWRTFFTVTLPGAKYGLISAAFVVFTLVITDFGVPKVIGGDYNVLATDIY 223

                         250
                  ....*....|..
gi 307615086  255 LMSIQQNAFGSG 266
Cdd:TIGR03262 224 KQVIGQQNFPMG 235
CysU COG0555
ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism]; ...
 17-300 2.70e-05

ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440321 [Multi-domain]  Cd Length: 268  Bit Score: 44.74  E-value: 2.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086  17 WATLFVGPHAILFVLFFLIPVVygvyvsftkwSLFNDPMWIGFKNYQELFFDRESIFHDQLIYGMS--STLIFVLFTVPL 94
Cdd:COG0555    8 GFGLTLGLTLLYLSLIVLLPLA----------ALVLKAAGLGWAEFWAVLTSPRVLAALKLSLGTAliAALINLVFGLPL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086  95 cilvplfAAGMLLTQNKLRKVFQAIFYIPSMF--AVSAVMLIFSFllsKSYGPLQGWFH-VDVNVTQTQPYAWIALVLVt 171
Cdd:COG0555   78 -------AWVLVRYRFPGKRLVDALVDLPFALptAVAGIALLLLF---GPNGWLGQLLApLGIKVAFTPLGIVLAQTFV- 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086 172 vwwcigqNLIIYI----AALAGVPRDQIDAARIDGASNWRILRQIQLPNIqLPmifTIITTTVLQF----NVYGQPLMLT 243
Cdd:COG0555  147 -------SLPFVVrtvqPVLEELDPELEEAAATLGASRWQTFRRVILPLL-LP---ALLTGFALAFaralGEFGAVIFIA 215

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 307615086 244 nGGPNNSTKVLLMSIQQNAFGSGIPAagmasaqATILGATIIIVSAIELLILKLCQR 300
Cdd:COG0555  216 -GNLPMKTEILPLLIYLKLEEGDYAG-------ATAIALVLLLISFLLLLLINLLQR 264
TauC COG0600
ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion ...
 165-224 1.34e-04

ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440365 [Multi-domain]  Cd Length: 254  Bit Score: 42.44  E-value: 1.34e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 307615086 165 IALVLVTVWWcigqnlIIYIAALAG---VPRDQIDAARIDGASNWRILRQIQLPNIqLPMIFT 224
Cdd:COG0600  129 IFVIFLGAFF------PILLNTAAGvrsVDPELLELARSLGASRWQILRKVVLPAA-LPYIFT 184
cysW PRK11602
sulfate/thiosulfate ABC transporter permease CysW;
15-228 1.99e-03

sulfate/thiosulfate ABC transporter permease CysW;


Pssm-ID: 183225  Cd Length: 283  Bit Score: 38.96  E-value: 1.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086  15 GLWATLFVGphAILFVLFFLIPVVYGVYVSFTKWSLfndPMWigfknyqelffdrESIFHDQLIYGMSSTLIFVLFTVPL 94
Cdd:PRK11602  18 GKWFLIGIG--MLVSAFILVVPMIYIFVQAFSKGLM---PVL-------------QNLADPDMLHAIWLTVLIALIAVPV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307615086  95 CILVPLFAAgMLLTQNKL--RKVFQAIFYIPsmFAVSAVMLIFSFLL-SKSYGPLQGWfhVDVNVTQTQpYAWIALVLVT 171
Cdd:PRK11602  80 NLVFGILLA-WLVTRFNFpgRQLLLTLLDIP--FAVSPVVAGLVYLLfYGSNGPLGGW--LDEHNLQLM-FSWPGMVLVT 153

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 307615086 172 VWWCIGQNLIIYIAALAGVPRDQIDAARIDGASNWRILRQIQLPNIQLPMIFTIITT 228
Cdd:PRK11602 154 IFVTCPFVVRELVPVMLSQGSQEDEAAILLGASGWQMFRRVTLPNIRWALLYGVVLT 210
PRK15050 PRK15050
2-aminoethylphosphonate transport system permease PhnU; Provisional
 184-215 2.16e-03

2-aminoethylphosphonate transport system permease PhnU; Provisional


Pssm-ID: 237888 [Multi-domain]  Cd Length: 296  Bit Score: 39.22  E-value: 2.16e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 307615086 184 IAALAGVPRDQIDAARIDGASNWRILRQIQLP 215
Cdd:PRK15050 181 LAAFAQLDARQLEAAASLGASPWRVARRVILP 212
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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