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Conserved domains on  [gi|308250905|gb|EFO94857|]
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hypothetical protein CRE_08878 [Caenorhabditis remanei]

Protein Classification

serpentine receptor( domain architecture ID 366230)

serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Srd super family cl22924
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 1-268 1.90e-105

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


The actual alignment was detected with superfamily member pfam10319:

Pssm-ID: 419896  Cd Length: 310  Bit Score: 309.56  E-value: 1.90e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308250905    1 MYINWPHYYIPKFNGLCSFLVNPIFIFIIFADKRLQLGNYRCLLLYFAIFNMICSACDILVPMRICNNVTAFS------- 73
Cdd:pfam10319   1 MYINWAHYYIPKIFGVLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVvfvsdgp 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308250905   74 ---------------------------------------NKFLAKYFLPYGMIASIVYCLFHMVYWIVACFYCIGADRER 114
Cdd:pfam10319  81 ffeyselgqhalsarcsfisasyavllihfiyrylvlfnPQLTRHYFRPWGILISILFFLFHGSVWTAICYFLLRANDEI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308250905  115 KLYMRETIKEVYGLDSLDINMIIALYRfqlqEGSYDAVQKSLIGVVSITFLSVDSVIIYFILGLLIMKRLGSNTLIMSKK 194
Cdd:pfam10319 161 RDYIREDFRETYGVDSMDINMLGALYW----EASDETVFRSWLGILLLTVISVYSIILYIVLGYKIMRKLNKMSVTMSKK 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 308250905  195 TKKLQAQLMKALIVQSVIPTVVSFAPCIFSWYQPVFGIELGRSVYHSAAIAVSAFPFLDPLAILFFVPTFRQRF 268
Cdd:pfam10319 237 TKRLQKQLLKALIVQTIIPICISFSPCVLAWYSPIFGIDLGRWNNYLEVIALSAFPFIDPLAIILCLPVYRNRI 310
 
Name Accession Description Interval E-value
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 1-268 1.90e-105

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 309.56  E-value: 1.90e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308250905    1 MYINWPHYYIPKFNGLCSFLVNPIFIFIIFADKRLQLGNYRCLLLYFAIFNMICSACDILVPMRICNNVTAFS------- 73
Cdd:pfam10319   1 MYINWAHYYIPKIFGVLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVvfvsdgp 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308250905   74 ---------------------------------------NKFLAKYFLPYGMIASIVYCLFHMVYWIVACFYCIGADRER 114
Cdd:pfam10319  81 ffeyselgqhalsarcsfisasyavllihfiyrylvlfnPQLTRHYFRPWGILISILFFLFHGSVWTAICYFLLRANDEI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308250905  115 KLYMRETIKEVYGLDSLDINMIIALYRfqlqEGSYDAVQKSLIGVVSITFLSVDSVIIYFILGLLIMKRLGSNTLIMSKK 194
Cdd:pfam10319 161 RDYIREDFRETYGVDSMDINMLGALYW----EASDETVFRSWLGILLLTVISVYSIILYIVLGYKIMRKLNKMSVTMSKK 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 308250905  195 TKKLQAQLMKALIVQSVIPTVVSFAPCIFSWYQPVFGIELGRSVYHSAAIAVSAFPFLDPLAILFFVPTFRQRF 268
Cdd:pfam10319 237 TKRLQKQLLKALIVQTIIPICISFSPCVLAWYSPIFGIDLGRWNNYLEVIALSAFPFIDPLAIILCLPVYRNRI 310
 
Name Accession Description Interval E-value
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 1-268 1.90e-105

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 309.56  E-value: 1.90e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308250905    1 MYINWPHYYIPKFNGLCSFLVNPIFIFIIFADKRLQLGNYRCLLLYFAIFNMICSACDILVPMRICNNVTAFS------- 73
Cdd:pfam10319   1 MYINWAHYYIPKIFGVLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVvfvsdgp 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308250905   74 ---------------------------------------NKFLAKYFLPYGMIASIVYCLFHMVYWIVACFYCIGADRER 114
Cdd:pfam10319  81 ffeyselgqhalsarcsfisasyavllihfiyrylvlfnPQLTRHYFRPWGILISILFFLFHGSVWTAICYFLLRANDEI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308250905  115 KLYMRETIKEVYGLDSLDINMIIALYRfqlqEGSYDAVQKSLIGVVSITFLSVDSVIIYFILGLLIMKRLGSNTLIMSKK 194
Cdd:pfam10319 161 RDYIREDFRETYGVDSMDINMLGALYW----EASDETVFRSWLGILLLTVISVYSIILYIVLGYKIMRKLNKMSVTMSKK 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 308250905  195 TKKLQAQLMKALIVQSVIPTVVSFAPCIFSWYQPVFGIELGRSVYHSAAIAVSAFPFLDPLAILFFVPTFRQRF 268
Cdd:pfam10319 237 TKRLQKQLLKALIVQTIIPICISFSPCVLAWYSPIFGIDLGRWNNYLEVIALSAFPFIDPLAIILCLPVYRNRI 310
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 8-269 1.75e-33

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 124.11  E-value: 1.75e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308250905    8 YYIPKFNGLCSFLVNPIFIFIIFADKRLQLGNYRCLLLYFAIFNMICSACDILV-PMRICNNVT---------------- 70
Cdd:pfam10326   2 HIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVkPFIHSYNSSfivfvdlkdlglsksv 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308250905   71 ----------------------------AFSNKFLAKYFLPYGMIASIVYCLFHMVYWIVACFYCIGADRERKLYMRETI 122
Cdd:pfam10326  82 gqillalycgfygvsisllavqfiyrylALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREEL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308250905  123 KEVYGLDSLDINMIIALYRFQLQEGSYDAVQKSLIGVVSITFLSVDSVIIYFILGLLIMKRLGSNTLIMSKKTKKLQAQL 202
Cdd:pfam10326 162 LENYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQL 241

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 308250905  203 MKALIVQSVIPTVVSFAPCIFSWYQPVFGIELGrSVYHSAAIAVSAFPFLDPLAILFFVPTFRQRFK 269
Cdd:pfam10326 242 FKALVIQTLIPTILMYIPVGILFLLPLFNIEIG-FLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 7-269 1.49e-11

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 63.72  E-value: 1.49e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308250905    7 HYYIPKFNGLCSFLvNPIFIFIIFADKRLQLGNYRCLLLYFAIFNMICSACDILVPMRICNN---VTAFSNKFLaKYFLP 83
Cdd:pfam10317   2 SIYYPIFFILGLIL-NLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIPNgvsMALISYGPC-KYFGP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308250905   84 ---YGMIASIVYCLFHMVYWIVACFY-----CIGADRERKLYMR-----------ETIKEVYGLDSLDINMIIALYRFQl 144
Cdd:pfam10317  80 wfcYSGYSLLQHFLLHSGWSLLLTFYyryyiLKHVDPKRKKLILliiihyipslsQLIVIFLSPTDFLPVEALTKELHP- 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308250905  145 qegSYDAVQKSLIGVVSITFLSVDSVIIYFILGLL------------IMKRLGSNTLIMSKKTKKLQAQLMKALIVQSVI 212
Cdd:pfam10317 159 ---NYNLTDYTVTGFSDLQSFPALINTLIMTIPVFpipiiililrrkILKLLNSNSVNMSPTTKAQHRQLIKGLTIQALL 235

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 308250905  213 PTVVSFAPCIFSWYQPVFGIELGRSVYHSAAIAVSAfPFLDPLAILFFVPTFRQRFK 269
Cdd:pfam10317 236 PLFSYIPGVTLYLLSQLTGTEFLILEYFIFVLPALP-PLLDPLITIYFVTPYRRAIL 291
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 156-231 2.41e-05

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 45.23  E-value: 2.41e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 308250905  156 LIGVVSITFLSVDSVIIYFILGLLIMKRLGSNTliMSKKTKKLQAQLMKALIVQSVIPTVVSFAPCIFSWYQPVFG 231
Cdd:pfam10318 187 LICIVLLILILIIQILFFVFLTIYYLFKSVKSS--LSKKTRKLQKKFFIALIIQVSIPLIVILIPLIYILFSIIFG 260
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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