NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|308435717|gb|EFP59512|]
View 

hypothetical protein HMPREF0321_2484 [Dermacoccus sp. Ellin185]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 229396)

helix-turn-helix domain-containing protein may bind DNA and be involved in the regulation of gene expression

Gene Ontology:  GO:0003677|GO:0006355

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
HTH_ARSR super family cl46857
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
1-30 5.01e-05

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


The actual alignment was detected with superfamily member pfam00486:

Pssm-ID: 481197 [Multi-domain]  Cd Length: 77  Bit Score: 36.34  E-value: 5.01e-05
                         10        20        30
                 ....*....|....*....|....*....|
gi 308435717   1 MHIAKLRPKLRVATGGQWQIETVRGAGFVL 30
Cdd:pfam00486 48 VHISRLRKKLEDDPRDPRLIKTVRGVGYRL 77
 
Name Accession Description Interval E-value
Trans_reg_C pfam00486
Transcriptional regulatory protein, C terminal;
1-30 5.01e-05

Transcriptional regulatory protein, C terminal;


Pssm-ID: 425712 [Multi-domain]  Cd Length: 77  Bit Score: 36.34  E-value: 5.01e-05
                         10        20        30
                 ....*....|....*....|....*....|
gi 308435717   1 MHIAKLRPKLRVATGGQWQIETVRGAGFVL 30
Cdd:pfam00486 48 VHISRLRKKLEDDPRDPRLIKTVRGVGYRL 77
trans_reg_C cd00383
DNA-binding effector domain of two-component system response regulators; Bacteria and some ...
1-30 9.48e-04

DNA-binding effector domain of two-component system response regulators; Bacteria and some eukaryotes use two-component signal transduction systems to detect and respond to changes in the environment. The systems consists of a sensor histidine kinase and a response regulator. The former autophosphorylates a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. This C-terminal effector domain belongs to the winged helix-turn-helix family of transcriptional regulators and contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunit of RNA polymerase.


Pssm-ID: 294013 [Multi-domain]  Cd Length: 89  Bit Score: 33.22  E-value: 9.48e-04
                        10        20        30
                ....*....|....*....|....*....|
gi 308435717  1 MHIAKLRPKLRvATGGQWQIETVRGAGFVL 30
Cdd:cd00383  61 VHISRLRKKLE-DDPEPRLIKTVRGVGYRL 89
Trans_reg_C smart00862
Transcriptional regulatory protein, C terminal; This domain is almost always found associated ...
1-30 2.89e-03

Transcriptional regulatory protein, C terminal; This domain is almost always found associated with the response regulator receiver domain. It may play a role in DNA binding.


Pssm-ID: 214866 [Multi-domain]  Cd Length: 76  Bit Score: 31.75  E-value: 2.89e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 308435717    1 MHIAKLRPKLRVATGGQWqIETVRGAGFVL 30
Cdd:smart00862 48 VHISRLRKKLEDDGDPRL-IETVRGVGYRL 76
 
Name Accession Description Interval E-value
Trans_reg_C pfam00486
Transcriptional regulatory protein, C terminal;
1-30 5.01e-05

Transcriptional regulatory protein, C terminal;


Pssm-ID: 425712 [Multi-domain]  Cd Length: 77  Bit Score: 36.34  E-value: 5.01e-05
                         10        20        30
                 ....*....|....*....|....*....|
gi 308435717   1 MHIAKLRPKLRVATGGQWQIETVRGAGFVL 30
Cdd:pfam00486 48 VHISRLRKKLEDDPRDPRLIKTVRGVGYRL 77
trans_reg_C cd00383
DNA-binding effector domain of two-component system response regulators; Bacteria and some ...
1-30 9.48e-04

DNA-binding effector domain of two-component system response regulators; Bacteria and some eukaryotes use two-component signal transduction systems to detect and respond to changes in the environment. The systems consists of a sensor histidine kinase and a response regulator. The former autophosphorylates a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. This C-terminal effector domain belongs to the winged helix-turn-helix family of transcriptional regulators and contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunit of RNA polymerase.


Pssm-ID: 294013 [Multi-domain]  Cd Length: 89  Bit Score: 33.22  E-value: 9.48e-04
                        10        20        30
                ....*....|....*....|....*....|
gi 308435717  1 MHIAKLRPKLRvATGGQWQIETVRGAGFVL 30
Cdd:cd00383  61 VHISRLRKKLE-DDPEPRLIKTVRGVGYRL 89
Trans_reg_C smart00862
Transcriptional regulatory protein, C terminal; This domain is almost always found associated ...
1-30 2.89e-03

Transcriptional regulatory protein, C terminal; This domain is almost always found associated with the response regulator receiver domain. It may play a role in DNA binding.


Pssm-ID: 214866 [Multi-domain]  Cd Length: 76  Bit Score: 31.75  E-value: 2.89e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 308435717    1 MHIAKLRPKLRVATGGQWqIETVRGAGFVL 30
Cdd:smart00862 48 VHISRLRKKLEDDGDPRL-IETVRGVGYRL 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH