|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
8-840 |
1.39e-149 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 462.58 E-value: 1.39e-149
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 8 QSGDGRRGRLRIFFGFAAGVGKTYGMLTEAHELLMMGKHVVVGYIEPHDRPDTNRLLEGLPQIPPKNIFYKQMVLTEPDI 87
Cdd:PRK10490 16 QTAEPHRGKLKIFFGACAGVGKTYAMLQEAQRLRAQGLDVLVGVVETHGRKETAALLEGLTVLPPKRIHHRGRHISEFDL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 88 DQIIQQKPEIVLIDELAHSNAEGSRNRKRYQDIDELLNAGIDVFTTVNVQHIESLNDIVEEVTGIEVKETVPDTFLRQAT 167
Cdd:PRK10490 96 DAALARRPALILMDELAHSNAPGSRHPKRWQDVEELLEAGIDVFTTVNVQHLESLNDVVGGVTGIQVRETVPDPFFDAAD 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 168 -IRVIDVEPDELIERLEQGKIYANENAKRALKNFFIPQKLDQLRGLAIQRASDHIN---RISGKTIGiQSK--------L 235
Cdd:PRK10490 176 eVVLVDLPPDDLRQRLNEGKVYIAGQAERAIEHFFRKGNLIALRELALRRTADRVDdqmRAWRDHQG-EEKvwhtrdaiL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 236 LTVVNDAfpkMTEKCIRWTARLAQGLVADWTVIQVRT------QENTPTNI----PLADKLGAEVISIEEDDSFETIVEF 305
Cdd:PRK10490 255 LCIGHNT---GSEKLVRTAARLAARLGSVWHAVYVETprlhrlPEKKRRAIlsalRLAQELGAETATLSDPAEEKAVLRY 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 306 AKMTGVTDIIMGKNLRQPWYEKifiEAFDDRLLKRLKDTELHLIPFNE----------EKRSLFFKTRKVIEGggkdLVI 375
Cdd:PRK10490 332 AREHNLGKIIIGRRASRRWWRR---ESFADRLARLGPDLDLVIVALDEpparaiakapDSRPFKEKWRVQIQG----CLV 404
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 376 AIGgvfLATVVTEL-MQYIHVGDQ-NLMLIYISFVLLVA----RTTSgyfwsSLSSILSVLSFNWFFVEPLYSLTVYKQG 449
Cdd:PRK10490 405 AIA---LCALITLIaMQWLPAFDAaNLVMLYLLGVVVVAlfygRWPS-----VVATVINVASFDLFFVAPRGTLAVSDVQ 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 450 YPFTLLLMLVVALMSSNLMIRLKKQADTSMKKEHQMEILYELNKRYVLVESRKQILDISATYLSRLLEREVIIF--DRQV 527
Cdd:PRK10490 477 YLLTFAVMLTVGLVIGNLTAGVRYQARVARYREQRTRHLYEMSKALAVGLSPEDIAATSEHFLASTFQARSQLLlpDDNG 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 528 KtesVHCINEKKSILNNEDeaAVAFWAAKNQKEAGNGTDTLNGAKGFYLPIAAGRKTLAVLGIE-RNADLDLENDQLNYL 606
Cdd:PRK10490 557 K---LQPLTHDQGMTPWDD--AIARWSFDKGQPAGAGTDTLPGVPYQILPLKSAQKTYGLLAVEpGNLRQLMIPEQQRLL 631
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 607 KLVLTQIAVILEQTELKDEKEQVELENEREKVRSNLLRAVSHDLRTPLTVISGIAETLGIgnDLKEETQRKLLKDIQEES 686
Cdd:PRK10490 632 ETFTLLIANALERLTLTASEEQARLASEREQLRNALLAALSHDLRTPLTVLFGQAEILTL--DLASEGSPHARQASEIRQ 709
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 687 QWL--IRMVENLLSITRINMDTMKVNKTAEPVEEVIEAVYKHLRKVYPDGQVDIHLPEEVIFIQADPILIEQALFNLIEN 764
Cdd:PRK10490 710 QVLntTRLVNNLLDMARIQSGGFNLRKEWLTLEEVVGSALQMLEPGLSGHPINLSLPEPLTLIHVDGPLFERVLINLLEN 789
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 765 AFRHGENDLPVKLNVYQGKEQTVFEIENHG-EIPLKQFQKIQLNLS-GTNE--VPvdsknGLGIGLSIVKTIVHAHNGKM 840
Cdd:PRK10490 790 AVKYAGAQAEIGIDAHVEGERLQLDVWDNGpGIPPGQEQLIFDKFArGNKEsaIP-----GVGLGLAICRAIVEVHGGTI 864
|
|
| KdpD |
pfam02702 |
Osmosensitive K+ channel His kinase sensor domain; This is a family of KdpD sensor kinase ... |
13-221 |
2.51e-118 |
|
Osmosensitive K+ channel His kinase sensor domain; This is a family of KdpD sensor kinase proteins that regulate the kdpFABC operon responsible for potassium transport. The aligned region corresponds to the N-terminal cytoplasmic part of the protein which functions as the sensor domain responsible for sensing turgor pressure. It recognizes C-di-AMP and K+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 460656 [Multi-domain] Cd Length: 210 Bit Score: 357.11 E-value: 2.51e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 13 RRGRLRIFFGFAAGVGKTYGMLTEAHELLMMGKHVVVGYIEPHDRPDTNRLLEGLPQIPPKNIFYKQMVLTEPDIDQIIQ 92
Cdd:pfam02702 1 RRGRLKIFLGAAPGVGKTYAMLQEAHRLKKRGVDVVIGYVETHGRPETEALLEGLEVIPRREIEYRGRTLEEMDLDAILA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 93 QKPEIVLIDELAHSNAEGSRNRKRYQDIDELLNAGIDVFTTVNVQHIESLNDIVEEVTGIEVKETVPDTFLRQAT-IRVI 171
Cdd:pfam02702 81 RRPEVVLVDELAHTNAPGSRHPKRWQDVEELLDAGIDVYTTVNIQHLESLNDVVEQITGVRVRETVPDSVLDRADeVELV 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 315027614 172 DVEPDELIERLEQGKIYANENAKRALKNFFIPQKLDQLRGLAIQRASDHI 221
Cdd:pfam02702 161 DLTPEELLERLKEGKVYPPEKAERALKNFFRKGNLTALRELALRRVADRV 210
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
626-855 |
6.63e-54 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 187.04 E-value: 6.63e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 626 KEQVELENEREKVRSNLLRAVSHDLRTPLTVISGIAETLGIGNDLKEETQRKLLKDIQEESQWLIRMVENLLSITRINMD 705
Cdd:COG2205 3 EEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLESG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 706 TMKVNKTAEPVEEVIEAVYKHLRKVYPDGQVDI--HLPEEVIFIQADPILIEQALFNLIENAFRHGENDLPVKLNVYQGK 783
Cdd:COG2205 83 KLSLELEPVDLAELLEEAVEELRPLAEEKGIRLelDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARREG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 784 EQTVFEIENHGE-IPLKQFQKI-----QLNLSgtnevpvDSKNGLGIGLSIVKTIVHAHNGKM--EMTIGRGkTLVRIYL 855
Cdd:COG2205 163 DGVRISVSDNGPgIPEEELERIferfyRGDNS-------RGEGGTGLGLAIVKRIVEAHGGTIwvESEPGGG-TTFTVTL 234
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
573-855 |
1.95e-44 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 165.11 E-value: 1.95e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 573 GFYLPIAAGRKTLAVLGIERNADLDLENDQLNYLKLVLTQIAVILEQTELKDEKEQVELEnereKVRSNLLRAVSHDLRT 652
Cdd:COG5002 103 ILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLE----QMRREFVANVSHELRT 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 653 PLTVISGIAETLGIGNDLKEETQRKLLKDIQEESQWLIRMVENLLSITRINMDTMKVNKTAEPVEEVIEAVYKHLRKVYP 732
Cdd:COG5002 179 PLTSIRGYLELLLDGAADDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAE 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 733 DGQVDIHL--PEEVIFIQADPILIEQALFNLIENAFRHGENDLPVKLNVYQGKEQTVFEIENHGE-IPLKQFQKI----- 804
Cdd:COG5002 259 EKGIELELdlPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIgIPEEDLPRIferfy 338
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 315027614 805 QLNLSGTNEVPvdsknGLGIGLSIVKTIVHAHNGKMEM--TIGRGkTLVRIYL 855
Cdd:COG5002 339 RVDKSRSRETG-----GTGLGLAIVKHIVEAHGGRIWVesEPGKG-TTFTITL 385
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
585-855 |
2.75e-41 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 154.30 E-value: 2.75e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 585 LAVLGIERNADLDLENDQLNYLKLVLTQIAVILEQTELKDEKEQVELEnEREKVRSNLLRAVSHDLRTPLTVISGIAETL 664
Cdd:COG0642 57 ALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLE-EANEAKSRFLANVSHELRTPLTAIRGYLELL 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 665 GIGNDlkeETQRKLLKDIQEESQWLIRMVENLLSITRINMDTMKVNKTAEPVEEVIEAVYKHLRKVYPDGQVDIHL--PE 742
Cdd:COG0642 136 LEELD---EEQREYLETILRSADRLLRLINDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELdlPD 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 743 EVIFIQADPILIEQALFNLIENAFRHGENDLPVKLNVYQGKEQTVFEIENHGE-IPLKQFQKI-----QLNlsgtnevPV 816
Cdd:COG0642 213 DLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREGDRVRISVEDTGPgIPPEDLERIfepffRTD-------PS 285
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 315027614 817 DSKNGLGIGLSIVKTIVHAHNGKMEM--TIGRGkTLVRIYL 855
Cdd:COG0642 286 RRGGGTGLGLAIVKRIVELHGGTIEVesEPGKG-TTFTVTL 325
|
|
| USP_KdpD-like |
cd01987 |
USP domain of the osmosensitive K+ channel histidine kinase family; The KdpDE two component ... |
234-350 |
1.25e-35 |
|
USP domain of the osmosensitive K+ channel histidine kinase family; The KdpDE two component system is widespread in bacteria and archaea; it controls potassium homeostasis and virulence by regulating the transcription of multiple genes, including a kdpFABC operon, which encodes a high-affinity P-type ATPase transporter. The KdpD histidine kinase (HK, EC:2.7.13.3) contain an N-terminal sensory cytoplasmic region (NTR) composed of KdpD' and universal stress protein (USP) domains, a canonical transmembrane domain, and a cytoplasmic C-terminal region with a transmitter GAF domain and an EnvZ-like catalytic HK domain. Proteins containing the USP domain are induced by many environmental stressors such as nutrient starvation, drought, extreme temperatures, high salinity, and the presence of uncouplers, antibiotics, and metals. It enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.
Pssm-ID: 467491 [Multi-domain] Cd Length: 124 Bit Score: 131.22 E-value: 1.25e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 234 KLLTVVNDafPKMTEKCIRWTARLAQGLVADWTVIQVRT----------QENTPTNIPLADKLGAEVISIEEDDSFETIV 303
Cdd:cd01987 1 RILVCISS--SPTSEKLIRRAARLAERLNGELTAVYVETpeesrldeesQRRLLTNLKLAEELGAEVVSVEGDDVAEAIV 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 315027614 304 EFAKMTGVTDIIMGKNLRQPWyEKIFIEAFDDRLLKRLKDTELHLIP 350
Cdd:cd01987 79 EFARERNVTQIVLGQSRRRRW-RRLFKGSLVDRLLREAPNIDVHIVP 124
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
630-855 |
6.56e-26 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 111.59 E-value: 6.56e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 630 ELENEREKVRSNLLRAVSHDLRTPLTVISGIAETL------GIGNDlkEETQRKLLKDIQEESQWLIRMVENLLSITRIn 703
Cdd:COG5000 192 LLRAERLAAWGELARRIAHEIKNPLTPIQLSAERLrrkladKLEED--REDLERALDTIIRQVDRLKRIVDEFLDFARL- 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 704 mdtMKVNKTAEPVEEVIEAVYKHLRKVYPDGQVDIH--LPEEVIFIQADPILIEQALFNLIENAFRHGENDLPVKLNVYQ 781
Cdd:COG5000 269 ---PEPQLEPVDLNELLREVLALYEPALKEKDIRLEldLDPDLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRR 345
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 315027614 782 GKEQTVFEIENHGE-IPLKQFQKIQlnlsgtneVP-VDSK-NGLGIGLSIVKTIVHAHNGKMEM--TIGRGkTLVRIYL 855
Cdd:COG5000 346 EDGRVRIEVSDNGPgIPEEVLERIF--------EPfFTTKpKGTGLGLAIVKKIVEEHGGTIELesRPGGG-TTFTIRL 415
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
497-855 |
1.50e-25 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 111.42 E-value: 1.50e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 497 LVESRKQILDISATYLSRLLEREVIIFDRQVKTESVHCINEKKSILNNEDEAAVAFWAAKNQKEAGNGTDTLNGAKGFYL 576
Cdd:COG4251 130 LLLALLLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLEL 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 577 PIAAGRKTLAVLGIERNADLDLENDQLNYLKLVLTQIAVILEQTELKDEKEQVELENEREKVRSNLLRA----------V 646
Cdd:COG4251 210 LLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAELERSneeleqfayvA 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 647 SHDLRTPLTVISGIAETLG--IGNDLKEETQRkLLKDIQEESQWLIRMVENLLSITRINMDTMKVnktaEPV--EEVIEA 722
Cdd:COG4251 290 SHDLREPLRKISGFSQLLEedYGDKLDEEGRE-YLERIRDAAERMQALIDDLLAYSRVGRQELEF----EPVdlNELLEE 364
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 723 VYKHLRKVYPDGQVDIH---LPEevifIQADPILIEQALFNLIENA--FRHGENDLPVKLNVYQGKEQTVFEIENHG-EI 796
Cdd:COG4251 365 VLEDLEPRIEERGAEIEvgpLPT----VRGDPTLLRQVFQNLISNAikYSRPGEPPRIEIGAEREGGEWVFSVRDNGiGI 440
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 315027614 797 PLKQFQKI-----QLNlsGTNEVPvdsknGLGIGLSIVKTIVHAHNGKM--EMTIGRGkTLVRIYL 855
Cdd:COG4251 441 DPEYAEKIfeifqRLH--SRDEYE-----GTGIGLAIVKKIVERHGGRIwvESEPGEG-ATFYFTL 498
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
636-849 |
1.94e-24 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 105.37 E-value: 1.94e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 636 EKVRSNLLRAVSHDLRTPLTVISGIAETLGIGNDLKEETQRKLLKDIQEESQWLIRMVENLLSITRINMDTMKVNKTAEP 715
Cdd:TIGR02966 111 EQMRRDFVANVSHELRTPLTVLRGYLETLADGPDEDPEEWNRALEIMLEQSQRMQSLVEDLLTLSRLESAASPLEDEPVD 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 716 VEEVIEAVYKHLR--KVYPDGQVDIHLpEEVIFIQADPILIEQALFNLIENAFRHGENDLPVKLNVYQGKEQTVFEIENH 793
Cdd:TIGR02966 191 MPALLDHLRDEAEalSQGKNHQITFEI-DGGVDVLGDEDELRSAFSNLVSNAIKYTPEGGTITVRWRRDGGGAEFSVTDT 269
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 315027614 794 GE-IPLKQFQKI-----QLNLSGTNEvpvdsKNGLGIGLSIVKTIVHAHNGKMEM--TIGRGKT 849
Cdd:TIGR02966 270 GIgIAPEHLPRLterfyRVDKSRSRD-----TGGTGLGLAIVKHVLSRHHARLEIesELGKGST 328
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
576-855 |
3.49e-21 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 96.41 E-value: 3.49e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 576 LPIAAGRKTLAVLGIERNADLDLENDQLNYLKLVLTQIAVILEQTElKDEKEQVELENEREKVRSNLLRA---------- 645
Cdd:COG4191 68 LLALLGGLLRLLLLLGLLLLLLLEALLLLLLAALDAEENAELEELE-RDITELERAEEELRELQEQLVQSeklaalgela 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 646 --VSHDLRTPLTVISGIAETLG--IGNDLKEETQRKLLKDIQEESQWLIRMVENLLSITRINMDTMKVNKTAEPVEEVIE 721
Cdd:COG4191 147 agIAHEINNPLAAILGNAELLRrrLEDEPDPEELREALERILEGAERAAEIVRSLRAFSRRDEEEREPVDLNELIDEALE 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 722 AVYKHLRKVypDGQVDIHLPEEVIFIQADPILIEQALFNLIENAF------RHGEndlpVKLNVYQGKEQTVFEIENHGE 795
Cdd:COG4191 227 LLRPRLKAR--GIEVELDLPPDLPPVLGDPGQLEQVLLNLLINAIdameegEGGR----ITISTRREGDYVVISVRDNGP 300
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 315027614 796 -IPLKQFQKIqlnlsgTNEVpvdsKNGLGIGLSIVKTIVHAHNGKMEM--TIGRGkTLVRIYL 855
Cdd:COG4191 301 gIPPEVLERIfepfftTKPV----GKGTGLGLSISYGIVEKHGGRIEVesEPGGG-TTFTITL 358
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
621-855 |
8.98e-21 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 94.91 E-value: 8.98e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 621 ELKDEKEQVELENE---REKVRSN--LLRAVSHDLRTPLTVISGIAETLGigNDLKEETQRKLLKDIQEESQWLIRMVEN 695
Cdd:COG3852 112 VLRDITERKRLERElrrAEKLAAVgeLAAGLAHEIRNPLTGIRGAAQLLE--RELPDDELREYTQLIIEEADRLNNLVDR 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 696 LLSITRinmdTMKVNKTAEPVEEVIEAVYKHLRKVYPDG-QVDIHLPEEVIFIQADPILIEQALFNLIENAF----RHGE 770
Cdd:COG3852 190 LLSFSR----PRPPEREPVNLHEVLERVLELLRAEAPKNiRIVRDYDPSLPEVLGDPDQLIQVLLNLVRNAAeampEGGT 265
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 771 ------NDLPVKLNVYQGKEQTVFEIENHGE-IPLKQFQKIQLnlsgtnevP-VDSK-NGLGIGLSIVKTIVHAHNGKME 841
Cdd:COG3852 266 itirtrVERQVTLGGLRPRLYVRIEVIDNGPgIPEEILDRIFE--------PfFTTKeKGTGLGLAIVQKIVEQHGGTIE 337
|
250
....*....|....*.
gi 315027614 842 MT--IGRGkTLVRIYL 855
Cdd:COG3852 338 VEsePGKG-TTFRIYL 352
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
630-855 |
5.64e-19 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 90.35 E-value: 5.64e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 630 ELENERekvrsNLLRA-VSHDLRTPLTVISGIAETLGIGND-LKEetqrKLLKDIQEESQWLIRMVENLLSITRINMDTM 707
Cdd:PRK09467 224 QLEDDR-----TLLMAgVSHDLRTPLTRIRLATEMMSEEDGyLAE----SINKDIEECNAIIEQFIDYLRTGQEMPMEMA 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 708 KVNKTaepVEEVIEAVYKHlrkvypDGQVDIHLPEEVIFIQADPILIEQALFNLIENAFRHGENDlpVKLNVYQGKEQTV 787
Cdd:PRK09467 295 DLNAL---LGEVIAAESGY------EREIETALQPGPIEVPMNPIAIKRALANLVVNAARYGNGW--IKVSSGTEGKRAW 363
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 315027614 788 FEIENHGE-IPLKQFQKI-----QLNLSGTNEvpvdsknGLGIGLSIVKTIVHAHNGKMEMTIG-RGKTLVRIYL 855
Cdd:PRK09467 364 FQVEDDGPgIPPEQLKHLfqpftRGDSARGSS-------GTGLGLAIVKRIVDQHNGKVELGNSeEGGLSARAWL 431
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
749-856 |
2.77e-16 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 75.38 E-value: 2.77e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 749 ADPILIEQALFNLIENAFRHGENDLPVKLNVYQGKEQTVFEIENHGE-IPLKQFQKIqLNLSGTNEVPVDSKNGLGIGLS 827
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPgIPPEDLEKI-FEPFFRTDKRSRKIGGTGLGLS 79
|
90 100 110
....*....|....*....|....*....|.
gi 315027614 828 IVKTIVHAHNGKMEM--TIGRGkTLVRIYLK 856
Cdd:smart00387 80 IVKKLVELHGGEISVesEPGGG-TTFTITLP 109
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
504-855 |
7.02e-15 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 77.58 E-value: 7.02e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 504 ILDISATYLSRLLEREVIIFDRQVKTESVHCINEKKSILNNEDEAAVAFwaaknqKEAGNGTDTLNGAKGFYLPIAAGRK 583
Cdd:COG3290 52 LLLILLLILLLLLLLLLAALLLKLLEEIARLVEEREAVLESIREGVIAV------DRDGRITLINDAARRLLGLDAIGRP 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 584 TLAVLGIERNADLDLENDQLNYLKLVLTQIAVILEQTE------LKDEKEQVELENEREKVRS--NLLRAVSHDLRTPLT 655
Cdd:COG3290 126 IDEVLAEVLETGERDEEILLNGRVLVVNRVPIRDDGRVvgavatFRDRTELERLEEELEGVKElaEALRAQRHDFRNHLH 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 656 VISGIAEtlgigndlkeetqrklLKDIQEESQWLIRMVENLLSITRINMDtmkvnKTAEP-VEEVIEAVYKHLRKVYPDg 734
Cdd:COG3290 206 TISGLLQ----------------LGEYDEALEYIDEISEELQELIDSLLS-----RIGNPvLAALLLGKAARARERGID- 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 735 qVDIHLPEEVIFIQADPILIEQALFNLIENAFRHGENDLP----VKLNVYQGKEQTVFEIENHG-EIPLKQFQKIQlnls 809
Cdd:COG3290 264 -LTIDIDSDLPDLPLSDTDLVTILGNLLDNAIEAVEKLPEeerrVELSIRDDGDELVIEVEDSGpGIPEELLEKIF---- 338
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 315027614 810 gTNEVPVDSKNGLGIGLSIVKTIVHAHNGKMEMTIGRGK-TLVRIYL 855
Cdd:COG3290 339 -ERGFSTKLGEGRGLGLALVKQIVEKYGGTIEVESEEGEgTVFTVRL 384
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
622-839 |
9.62e-15 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 76.91 E-value: 9.62e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 622 LKDEKEQVElenEREKVRSNLLRAVSHDLRTPLTVISgIA-ETLGIG-----NDLKEETQRKLLKDIQEESQWLIRMVEN 695
Cdd:PRK09303 137 LRQENETLL---EQLKFKDRVLAMLAHDLRTPLTAAS-LAlETLELGqidedTELKPALIEQLQDQARRQLEEIERLITD 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 696 LLSITRINMDTMKVNktaePVE--------EVIEAVYKHLRKVYPDGQVDIhlPEEVIFIQADPILIEQALFNLIENAFR 767
Cdd:PRK09303 213 LLEVGRTRWEALRFN----PQKldlgslcqEVILELEKRWLAKSLEIQTDI--PSDLPSVYADQERIRQVLLNLLDNAIK 286
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 315027614 768 HGENDLPVKLNVYQGKEQTV-FEIENHGE-IPLKQFQKIqlnLSGTNEVPVD-SKNGLGIGLSIVKTIVHAHNGK 839
Cdd:PRK09303 287 YTPEGGTITLSMLHRTTQKVqVSICDTGPgIPEEEQERI---FEDRVRLPRDeGTEGYGIGLSVCRRIVRVHYGQ 358
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
636-701 |
8.44e-14 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 66.85 E-value: 8.44e-14
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 315027614 636 EKVRSNLLRAVSHDLRTPLTVISGIAETLgIGNDLKEETQRKLLKDIQEESQWLIRMVENLLSITR 701
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELL-EEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| DUF4118 |
pfam13493 |
Domain of unknown function (DUF4118); This domain is found in a wide variety of bacterial ... |
373-481 |
1.87e-13 |
|
Domain of unknown function (DUF4118); This domain is found in a wide variety of bacterial signalling proteins. It is likely to be a transmembrane domain involved in ligand sensing.
Pssm-ID: 463897 Cd Length: 107 Bit Score: 67.10 E-value: 1.87e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 373 LVIAIGGVFLATVVTELMQYIhVGDQNLMLIYISFVLLVARTTsGYFWSSLSSILSVLSFNWFFVEPLYSLTVYKQGYPF 452
Cdd:pfam13493 1 YLLAVLILALATLLALLLRPL-LPLANIALLFLLAVLLVALRG-GRGPGLLAAVLSVLLFNYFFTPPYFTFTVSDPGYLL 78
|
90 100
....*....|....*....|....*....
gi 315027614 453 TLLLMLVVALMSSNLMIRLKKQADTSMKK 481
Cdd:pfam13493 79 TLVVFLLVALLTSTLTARLRRQARQARRR 107
|
|
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
613-839 |
1.97e-13 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 74.02 E-value: 1.97e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 613 IAVileqteLKDEKEQVELENEREKVRSNllraVSHDLRTPLTVISGIAETLGIG--NDlkEETQRKLLKDIQEESQWLI 690
Cdd:NF033092 356 IAV------LHDVTEQEKIEQERREFVAN----VSHELRTPLTTMRSYLEALADGawKD--PELAPRFLGVTQNETERMI 423
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 691 RMVENLLSITRINMDTMKVNKT----AEPVEEVI---EAVYKHlRKVypdgQVDIHLPEEVIFIQADPILIEQALFNLIE 763
Cdd:NF033092 424 RLVNDLLQLSRMDSKDYKLNKEwvnfNEFFNYIIdrfEMILKN-KNI----TFKREFPKRDLWVEIDTDKITQVLDNIIS 498
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 764 NAFRHGENDLPVKLNVYQGKEQTVFEIENHG-EIPLKQFQKI-----------QLNLSGTnevpvdsknglGIGLSIVKT 831
Cdd:NF033092 499 NAIKYSPEGGTITFRLLETHNRIIISISDQGlGIPKKDLDKIfdrfyrvdkarSRKMGGT-----------GLGLAIAKE 567
|
....*...
gi 315027614 832 IVHAHNGK 839
Cdd:NF033092 568 VVEAHGGR 575
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
644-841 |
3.06e-13 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 72.95 E-value: 3.06e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 644 RAVSHDLRTPLTVISGIAETLGigNDLKEETQRKLLKDIQEESQWLIRMVENLLSITR------------INMDTMkVNK 711
Cdd:PRK11100 261 QTLTHELKSPLAAIRGAAELLQ--EDPPPEDRARFTGNILTQSARLQQLIDRLLELARleqrqelevlepVALAAL-LEE 337
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 712 TAEPVEevIEAVYKHLrkvypdgQVDIHLPEevIFIQADPILIEQALFNLIENA--F--RHGEndlpVKLNVYQGKEQTV 787
Cdd:PRK11100 338 LVEARE--AQAAAKGI-------TLRLRPDD--ARVLGDPFLLRQALGNLLDNAidFspEGGT----ITLSAEVDGEQVA 402
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 315027614 788 FEIENHGE-IPL----KQFQKIqLNLSGtnevPVDSKNGLGIGLSIVKTIVHAHNGKME 841
Cdd:PRK11100 403 LSVEDQGPgIPDyalpRIFERF-YSLPR----PANGRKSTGLGLAFVREVARLHGGEVT 456
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
639-702 |
5.88e-13 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 64.54 E-value: 5.88e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 315027614 639 RSNLLRAVSHDLRTPLTVISGIAETLgiGNDLKEETQRKLLKDIQEESQWLIRMVENLLSITRI 702
Cdd:pfam00512 2 KSEFLANLSHELRTPLTAIRGYLELL--RDEKLDEEQREYLETILRSAERLLRLINDLLDLSRI 63
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
622-856 |
1.72e-12 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 71.15 E-value: 1.72e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 622 LKDEKEQVELEN-----EREKVRSNLLRAVSHDLRTPLTVISGIAETLGIGNDLKEetQRKLLKDIQEESQWLIRMVENL 696
Cdd:PRK11360 368 FSDLTERKRLQRrvarqERLAALGELVAGVAHEIRNPLTAIRGYVQIWRQQTSDPP--SQEYLSVVLREVDRLNKVIDQL 445
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 697 LSITRINmdtmKVNKTAEPVEEVIEAVYKHLRKVYPDGQVDIH--LPEEVIFIQADPILIEQALFNLIENAFRHGENDLP 774
Cdd:PRK11360 446 LEFSRPR----ESQWQPVSLNALVEEVLQLFQTAGVQARVDFEteLDNELPPIWADPELLKQVLLNILINAVQAISARGK 521
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 775 VKLNVYQ-GKEQTVFEIENHG-EIPLKQFQKI-----QLNLSGTnevpvdsknglGIGLSIVKTIVHAHNGKMEM--TIG 845
Cdd:PRK11360 522 IRIRTWQySDGQVAVSIEDNGcGIDPELLKKIfdpffTTKAKGT-----------GLGLALSQRIINAHGGDIEVesEPG 590
|
250
....*....|.
gi 315027614 846 RGkTLVRIYLK 856
Cdd:PRK11360 591 VG-TTFTLYLP 600
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
639-702 |
3.13e-12 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 62.20 E-value: 3.13e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 315027614 639 RSNLLRAVSHDLRTPLTVISGIAETLgiGNDLKEETQRKLLKDIQEESQWLIRMVENLLSITRI 702
Cdd:smart00388 2 KREFLANLSHELRTPLTAIRGYLELL--LDTELSEEQREYLETILREAERLLRLINDLLDLSRI 63
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
639-838 |
1.60e-11 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 67.32 E-value: 1.60e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 639 RSNLLRAVSHDLRTPLTVISgiaETLGIGNDLKEETQRKLLKDI-QEESqwlirMVENLLSITRinMDTMKVNKTAEPVE 717
Cdd:PRK10604 212 KKQLIDGIAHELRTPLVRLR---YRLEMSDNLSAAESQALNRDIgQLEA-----LIEELLTYAR--LDRPQNELHLSEPD 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 718 --EVIEAVYKHLRKVYPDGQVDIHLPEEVIFIQADPILIEQALFNLIENAFRHGENDLPVKLNVYQGkeQTVFEIENHGE 795
Cdd:PRK10604 282 lpAWLSTHLADIQAVTPEKTVRLDTPHQGDYGALDMRLMERVLDNLLNNALRYAHSRVRVSLLLDGN--QACLIVEDDGP 359
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 315027614 796 -IPLKQFQKI-----QLNLSGTNevpvdSKNGLGIGLSIVKTIVHAHNG 838
Cdd:PRK10604 360 gIPPEERERVfepfvRLDPSRDR-----ATGGCGLGLAIVHSIALAMGG 403
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
646-849 |
4.10e-11 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 66.26 E-value: 4.10e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 646 VSHDLRTPLTVISGIAETLgIGNDLKEETQRKLLKDIQEESQWLIRMVENLLSITRINMDTMKVNKTAEPVEEVIEAVYK 725
Cdd:TIGR01386 248 LAHELRTPLTNLLGQTQVA-LSQPRTGEEYREVLESNLEELERLSRMVSDMLFLARADNGQLALERVRLDLAAELAKVAE 326
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 726 HLRKVYPDGQVDIHLPEEViFIQADPILIEQALFNLIENAFRHGENDLPVKLNVYQGKEQTVFEIENHGE-IPLKQFQKI 804
Cdd:TIGR01386 327 YFEPLAEERGVRIRVEGEG-LVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVSVSNPGPgIPPEHLSRL 405
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 315027614 805 QLNLSGTNEVPVDSKNGLGIGLSIVKTIVHAHNGKMEMTIGRGKT 849
Cdd:TIGR01386 406 FDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAESPDGKT 450
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
749-856 |
7.97e-11 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 59.69 E-value: 7.97e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 749 ADPILIEQALFNLIENAFRHGENDLPVKLNVYQGkEQTVFEIENHGE-IPLKQFQKIqlnLSGTNEVPVDSKNGLGIGLS 827
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSEG-GELTLTVEDNGIgIPPEDLPRI---FEPFSTADKRGGGGTGLGLS 76
|
90 100 110
....*....|....*....|....*....|
gi 315027614 828 IVKTIVHAHNGKMEMTIGRGK-TLVRIYLK 856
Cdd:pfam02518 77 IVRKLVELLGGTITVESEPGGgTTVTLTLP 106
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
622-855 |
2.71e-09 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 60.37 E-value: 2.71e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 622 LKDEKEQVELE-----NEREKVRSNLLRAVSHDLRTPLTVISGIAETLgigNDLKEETQRKLLKDIQEESQWLIRMVENL 696
Cdd:COG5809 248 FRDITERKKLEellrkSEKLSVVGELAAGIAHEIRNPLTSLKGFIQLL---KDTIDEEQKTYLDIMLSELDRIESIISEF 324
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 697 LSITRINMDTMKVNKTAEPVEEVI-----EAVYKHLrkvypdgQVDIHLPEEVIFIQADPILIEQALFNLIENAF----R 767
Cdd:COG5809 325 LVLAKPQAIKYEPKDLNTLIEEVIpllqpQALLKNV-------QIELELEDDIPDILGDENQLKQVFINLLKNAIeampE 397
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 768 HGEndLPVKLNvYQGKEQTVFEIENHGE-IPLKQFQKIQLNLSGTNEvpvdskNGLGIGLSIVKTIVHAHNGKMEMT--I 844
Cdd:COG5809 398 GGN--ITIETK-AEDDDKVVISVTDEGCgIPEERLKKLGEPFYTTKE------KGTGLGLMVSYKIIEEHGGKITVEseV 468
|
250
....*....|.
gi 315027614 845 GRGkTLVRIYL 855
Cdd:COG5809 469 GKG-TTFSITL 478
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
742-851 |
1.37e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 53.56 E-value: 1.37e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 742 EEVIFIQADPILIEQALFNLIENAFRHGENDLPVKLNVyQGKEQTVFEIENHGE-IPLKQFQKIqlnlsGTNEVPVDSKN 820
Cdd:cd16940 2 AADIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKL-SADDGAVIRVEDNGPgIDEEELEAL-----FERFYRSDGQN 75
|
90 100 110
....*....|....*....|....*....|...
gi 315027614 821 --GLGIGLSIVKTIVHAHNGKMEMTIGRGKTLV 851
Cdd:cd16940 76 ygGSGLGLSIVKRIVELHGGQIFLGNAQGGGLE 108
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
646-779 |
2.66e-08 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 57.34 E-value: 2.66e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 646 VSHDLRTPLTVISGIAETLGIGNDLKEETQRKLLKDIQEESQWLIRMVENLLSITRinMDTMKVNKTAEPV--EEVIEAV 723
Cdd:NF040691 278 VSHELRTPLTTIRMAADVIHDSRDDFDPATARSAELLHTELDRFESLLSDLLEISR--FDAGAAELDVEPVdlRPLVRRV 355
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 315027614 724 YKHLRKVYPDGQVDIHL--PEEVIFIQADPILIEQALFNLIENAFRHGENdLPVKLNV 779
Cdd:NF040691 356 VDALRQLAERAGVELRVdaPGTPVVAEVDPRRVERVLRNLVVNAIEHGEG-KPVVVTV 412
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
620-856 |
4.19e-08 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 56.66 E-value: 4.19e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 620 TELKdEKEQVELENEREKVRSNLLRAVSHDLRTPLTVISGIAETLGIGndlkEETQRKLLKDIQEEsqwLIRM---VENL 696
Cdd:COG5805 269 TEKK-EAEELMARSEKLSIAGQLAAGIAHEIRNPLTSIKGFLQLLQPG----IEDKEEYFDIMLSE---LDRIesiISEF 340
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 697 LSITRinmdTMKVNKTAEPVEEVIEAVYKHLRK--VYPDGQVDIHLPEEVIFIQADPILIEQALFNLIENAFRHGENDLP 774
Cdd:COG5805 341 LALAK----PQAVNKEKENINELIQDVVTLLETeaILHNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGT 416
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 775 VKLNVYQGKEQTVFEIENHGE-IPLKQFQKIQLNLSGTNEvpvdskNGLGIGLSIVKTIVHAHNGKMEMTIGRGK-TLVR 852
Cdd:COG5805 417 ITIHTEEEDNSVIIRVIDEGIgIPEERLKKLGEPFFTTKE------KGTGLGLMVSYKIIENHNGTIDIDSKVGKgTTFT 490
|
....
gi 315027614 853 IYLK 856
Cdd:COG5805 491 ITLP 494
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
750-849 |
7.95e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 51.31 E-value: 7.95e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 750 DPILIEQALFNLIENAFRHGENDLPVKLNVYQGKEQTVFEIENHGEIPLKQFQKIQLNLSGTNEVPVDSKNGLGIGLSIV 829
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGGHYGMGLYIA 80
|
90 100
....*....|....*....|
gi 315027614 830 KTIVHAHNGkmEMTIGRGKT 849
Cdd:cd16975 81 KNLVEKHGG--SLIIENSQK 98
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
636-840 |
9.03e-08 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 55.41 E-value: 9.03e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 636 EKVRSNLLRAVSHDLRTPLTVISGIAETLGIGndlkeetQRKL----LKDIQEESQWLIRMVENLLSITRINMDTMKVNK 711
Cdd:PRK10549 237 EQMRRDFMADISHELRTPLAVLRGELEAIQDG-------VRKFtpesVASLQAEVGTLTKLVDDLHQLSLSDEGALAYRK 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 712 TAEPVEEVIEAVYKHLRKVYPDGQ--VDIHLPEEVIFIqADPILIEQALFNLIENAFR----HGEndLPVKLNVYQGKEQ 785
Cdd:PRK10549 310 TPVDLVPLLEVAGGAFRERFASRGltLQLSLPDSATVF-GDPDRLMQLFNNLLENSLRytdsGGS--LHISAEQRDKTLR 386
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 315027614 786 TVFEIENHGeIPLKQFQKIQLNLSGTNevpvDSKN----GLGIGLSIVKTIVHAHNGKM 840
Cdd:PRK10549 387 LTFADSAPG-VSDEQLQKLFERFYRTE----GSRNrasgGSGLGLAICLNIVEAHNGRI 440
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
630-855 |
1.23e-07 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 55.18 E-value: 1.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 630 ELENE---REKVRS--NLLRAVSHDLRTPLTVISGIAETLGigNDLKEETQ-RKLLKDIQEESQWLIRMVENLLSITRin 703
Cdd:PRK10364 223 LLQDEmkrKEKLVAlgHLAAGVAHEIRNPLSSIKGLAKYFA--ERAPAGGEaHQLAQVMAKEADRLNRVVSELLELVK-- 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 704 mdtmKVNKTAEPVeeVIEAVYKH-LRKVYPDG-----QVDIHLPEEVIFIQADPILIEQALFNLIENAFRHGENDLPVKL 777
Cdd:PRK10364 299 ----PTHLALQAV--DLNDLINHsLQLVSQDAnsreiQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGVISV 372
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 778 NVYQGKEQTVFEIENHGE-IPLKQFQKIQLNLSGTNevpvdsKNGLGIGLSIVKTIVHAHNGKMEMTIGRGK-TLVRIYL 855
Cdd:PRK10364 373 TASESGAGVKISVTDSGKgIAADQLEAIFTPYFTTK------AEGTGLGLAVVHNIVEQHGGTIQVASQEGKgATFTLWL 446
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
636-849 |
1.68e-07 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 54.63 E-value: 1.68e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 636 EKVRSNLLRAVSHDLRTPLTVISGIAETLGiGNDLKEETQRKLLKDIQEESQWLIRMVENLLSITRINmdtmkvnktAEP 715
Cdd:PRK11006 201 EGARRNFFANVSHELRTPLTVLQGYLEMMQ-DQPLEGALREKALHTMREQTQRMEGLVKQLLTLSKIE---------AAP 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 716 V---EEVIEaVYKHLRKVYPDGQVDIHLPEEVIFiQADPILI-----EQ---ALFNLIENAFRHGENDLPVKLNVYQGKE 784
Cdd:PRK11006 271 TidlNEKVD-VPMMLRVLEREAQTLSQGKHTITF-EVDNSLKvfgneDQlrsAISNLVYNAVNHTPEGTHITVRWQRVPQ 348
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 785 QTVFEIENHGE------IP--LKQFQKiqlnlsgtnevpVD---SKN--GLGIGLSIVKTIVHAHNGKMEM--TIGRGKT 849
Cdd:PRK11006 349 GAEFSVEDNGPgiapehIPrlTERFYR------------VDkarSRQtgGSGLGLAIVKHALSHHDSRLEIesEVGKGTR 416
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
754-855 |
1.85e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 49.75 E-value: 1.85e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 754 IEQALFNLIENAFRHGenDLPVKLNVYQGKEQTVFEIENHGE-IPLKQFQKIqLNLSGTNEVPVDSKnGLGIGLSIVKTI 832
Cdd:cd16950 1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQVLDNGPgIAPEEVDEL-FQPFYRGDNARGTS-GTGLGLAIVQRI 76
|
90 100
....*....|....*....|....
gi 315027614 833 VHAHNGKMEM-TIGRGKTLVRIYL 855
Cdd:cd16950 77 SDAHGGSLTLaNRAGGGLCARIEL 100
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
618-843 |
3.29e-07 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 54.14 E-value: 3.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 618 EQTELKDEKEQVELENER-EKVRSNLLRAVSHDLRTPLTVISGIAETLGiGNDLKEEtQRKLLKDIQEESQWLIRMVENL 696
Cdd:PRK11466 422 ELQELVIEHRQARAEAEKaSQAKSAFLAAMSHEIRTPLYGILGTAQLLA-DNPALNA-QRDDLRAITDSGESLLTILNDI 499
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 697 LSITRINMDTMKVNKTAEPVE--EVIEAVYK------HLRKVYPDGQVDIHLPEeviFIQADPILIEQALFNLIENAFRH 768
Cdd:PRK11466 500 LDYSAIEAGGKNVSVSDEPFEprPLLESTLQlmsgrvKGRPIRLATDIADDLPT---ALMGDPRRIRQVITNLLSNALRF 576
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 315027614 769 GENDLpVKLNVYQGKEQTVFEIENHG-EIPLKQFQKI---QLNLSGtnevpvdSKNGLGIGLSIVKTIVHAHNGKMEMT 843
Cdd:PRK11466 577 TDEGS-IVLRSRTDGEQWLVEVEDSGcGIDPAKLAEIfqpFVQVSG-------KRGGTGLGLTISSRLAQAMGGELSAT 647
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
642-839 |
3.58e-07 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 53.78 E-value: 3.58e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 642 LLRAVSHDLRTPLTvisgiaeTLGIGNDLkeeTQRKL-----LKDIQEESQWLIRMVENLLSITRINMD---TMKVNKTA 713
Cdd:PRK09470 246 LLSDISHELRTPLT-------RLQLATAL---LRRRQgeskeLERIETEAQRLDSMINDLLVLSRNQQKnhlERETFKAN 315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 714 EPVEEVI-------EAVYKHLRKVYPdgqvdihlPEEvIFIQADPILIEQALFNLIENAFRHGENDLPVKLNVyqgKEQT 786
Cdd:PRK09470 316 SLWSEVLedakfeaEQMGKSLTVSAP--------PGP-WPINGNPNALASALENIVRNALRYSHTKIEVAFSV---DKDG 383
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 315027614 787 VF-EIENHGE-IPLKQFQKIQLNLSGTNEVPVDSKNGLGIGLSIVKTIVHAHNGK 839
Cdd:PRK09470 384 LTiTVDDDGPgVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGW 438
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
639-843 |
6.12e-07 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 52.85 E-value: 6.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 639 RSNLLRAVSHDLRTPLTVISGIAETLgigndLKEETQRKLLKDI----QEESQWLIRMVENLLSITRINMDTMKVNKTAE 714
Cdd:PRK09835 262 QSNFSADIAHEIRTPITNLITQTEIA-----LSQSRSQKELEDVlysnLEELTRMAKMVSDMLFLAQADNNQLIPEKKML 336
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 715 PVEEVIEAVYKHLRKVYPDGQVDIHLPEEVIFIQADPILIEQALFNLIENAFRHGENDLPVKLNVYQGKEQTVFEIENHG 794
Cdd:PRK09835 337 DLADEVGKVFDFFEAWAEERGVELRFVGDPCQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPG 416
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 315027614 795 E-IPLKQFQKIQLNLSGTNEVPVDSKNGLGIGLSIVKTIVHAHNGKMEMT 843
Cdd:PRK09835 417 TpIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVT 466
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
727-840 |
8.30e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 49.17 E-value: 8.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 727 LRKVYPDGQVDI--HLPEEVIFIQADPILIEqALFNLIENAFRHGenDLPVKLNVYQGKEQTVFEIENHGE-IPLKQFQK 803
Cdd:cd16954 10 LNKVYQRKGVSIslDISPELRFPGERNDLME-LLGNLLDNACKWC--LEFVEVTARQTDGGLHLIVDDDGPgVPESQRSK 86
|
90 100 110
....*....|....*....|....*....|....*...
gi 315027614 804 I-QLNLSGTNEVPvdsknGLGIGLSIVKTIVHAHNGKM 840
Cdd:cd16954 87 IfQRGQRLDEQRP-----GQGLGLAIAKEIVEQYGGEL 119
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
607-838 |
1.06e-06 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 52.38 E-value: 1.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 607 KLVLTQIAVILEQTELKDE-KEQVELENEREKVRSNLLRA------------VSHDLRTPLTVISGIAETLGIGndLKEE 673
Cdd:COG4192 388 LLRVFRDQAIEKTQELETEiEERKRIEKNLRQTQDELIQAakmavvgqtmtsLAHELNQPLNAMSMYLFSAKKA--LEQE 465
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 674 TQRKLLKDIQEESQWLIRM---VENLLSITRINMDTMkvnkTAEPVEEVIEAVYKHLRKVYPDGQVDIHLPEEViFIQAD 750
Cdd:COG4192 466 NYAQLPTSLDKIEGLIERMdkiIKSLRQFSRKSDTPL----QPVDLRQVIEQAWELVESRAKPQQITLHIPDDL-MVQGD 540
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 751 PILIEQALFNLIENAFRHGENDLPVKLNVY-QGKEQTVFEIENHGEIPLkqFQKIQLNLSGTNEVpvdsknGLGIGLSIV 829
Cdd:COG4192 541 QVLLEQVLVNLLVNALDAVATQPQISVDLLsNAENLRVAISDNGNGWPL--VDKLFTPFTTTKEV------GLGLGLSIC 612
|
....*....
gi 315027614 830 KTIVHAHNG 838
Cdd:COG4192 613 RSIMQQFGG 621
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
631-856 |
1.18e-06 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 51.51 E-value: 1.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 631 LENERekvrsnLLRA-VSHDLRTPLtviSGIAETLgignDLKEETQ----RKLLKDIQEesqwLIRMVENLLSITRINMD 705
Cdd:PRK10755 134 LDQER------LFTAdVAHELRTPL---AGIRLHL----ELLEKQHhidvAPLIARLDQ----MMHTVEQLLQLARAGQS 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 706 -TMKVNKTAEPVEEVIEAVYKHLRKVYPDGQVDIHLPE--EVIFIQADPILIEQALFNLIENAFRHG--ENDLPVKLNVY 780
Cdd:PRK10755 197 fSSGHYQTVKLLEDVILPSQDELSEMLEQRQQTLLLPEsaADITVQGDATLLRLLLRNLVENAHRYSpeGSTITIKLSQE 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 781 -QGKEQTVFEI-----ENH-GEIpLKQFQKIqlnlsgtnevpvDSK-NGLGIGLSIVKTIVHAHNGK--MEMTIGRGKTL 850
Cdd:PRK10755 277 dGGAVLAVEDEgpgidESKcGEL-SKAFVRM------------DSRyGGIGLGLSIVSRITQLHHGQffLQNRQERSGTR 343
|
....*.
gi 315027614 851 VRIYLK 856
Cdd:PRK10755 344 AWVWLP 349
|
|
| GAF_3 |
pfam13492 |
GAF domain; |
502-619 |
2.16e-06 |
|
GAF domain;
Pssm-ID: 433253 [Multi-domain] Cd Length: 129 Bit Score: 47.75 E-value: 2.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 502 KQILDISATYLSRLLEREVIIF----DRQVKTESVHCINEKKSILNNEDEAAVAFWAAKNQKEA-----GNGTDTLNGAK 572
Cdd:pfam13492 3 DEILEALLKLLVRLLGAERAAVylldEDGNKLQVAAGYDGEPDPSESLDADSPLARRALSSGEPisglgSAGEDGLPDGP 82
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 315027614 573 GFYLPIAAGRKTLAVLGIERNADLDLENDQLNYLKLVLTQIAVILEQ 619
Cdd:pfam13492 83 ALVVPLVAGRRVIGVLALASSKPRAFDAEDLRLLESLAAQIATAIEN 129
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
614-851 |
2.45e-06 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 51.57 E-value: 2.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 614 AVILEQT-ELKDEKEQVELENERekvRSNLLRAVSHDLRTPLTVISGIAETLGIG-NDLKeetQRKLLKDIQEESQWLIR 691
Cdd:PRK15347 375 NKVAERTqALAEAKQRAEQANKR---KSEHLTTISHEIRTPLNGVLGALELLQNTpLTAE---QMDLADTARQCTLSLLA 448
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 692 MVENLLSITRINMDTMKVNKTAEPVEEVIE---------AVYKHLR-KVYpdgqVDIHLPEEvifIQADPILIEQALFNL 761
Cdd:PRK15347 449 IINNLLDFSRIESGQMTLSLEETALLPLLDqamltiqgpAQSKSLTlRTF----VGAHVPLY---LHLDSLRLRQILVNL 521
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 762 IENAFR---HGEndlpVKLNVYQGKEQTVFEIENHGE-IPLKQFQKI-------QLNLSGTnevpvdsknglGIGLSIVK 830
Cdd:PRK15347 522 LGNAVKfteTGG----IRLRVKRHEQQLCFTVEDTGCgIDIQQQQQIftpfyqaDTHSQGT-----------GLGLTIAS 586
|
250 260
....*....|....*....|...
gi 315027614 831 TIVHAHNG--KMEMTIGRGKTLV 851
Cdd:PRK15347 587 SLAKMMGGelTLFSTPGVGSCFS 609
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
735-840 |
6.86e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 45.97 E-value: 6.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 735 QVDIHLPEEVIFIQADPILIEQALFNLIENAFRHGENDLPVKLNVYQGKEQTVFEIENHGE-IPLKQFQKIQLNLSGTNE 813
Cdd:cd16947 2 QVEINIPDRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKgISETEKDHVFERLYTLED 81
|
90 100
....*....|....*....|....*..
gi 315027614 814 VPVDSKNGLGIGLSIVKTIVHAHNGKM 840
Cdd:cd16947 82 SRNSAKQGNGLGLTITKRLAESMGGSI 108
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
754-840 |
9.73e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 45.01 E-value: 9.73e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 754 IEQALFNLIENAFRHGENDlpVKLNVYQGKEQTVFEIENHGE-IPLKQFQKIQLNLSGTNEVPVDSKNGLGIGLSIVKTI 832
Cdd:cd16949 1 LARALENVLRNALRYSPSK--ILLDISQDGDQWTITITDDGPgVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERA 78
|
....*...
gi 315027614 833 VHAHNGKM 840
Cdd:cd16949 79 IEQHGGKI 86
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
691-855 |
4.22e-05 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 46.93 E-value: 4.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 691 RMVENLLSITRINMDTmkvNKTAEPVEEVIEAV--Y---KHLRkvYPDG-QVDIHLPEEVIFIQaDPILIEQalfNLIEN 764
Cdd:COG2972 277 EMLEALSKLLRYSLSK---GDELVTLEEELELIksYleiQKLR--FGDRlEVEIEIDEELLDLL-IPKLILQ---PLVEN 347
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 765 AFRHGENDLP----VKLNVYQGKEQTVFEIENHGE-IPLKQFQKIQLNLSgtnevpvDSKNGLGIGLSIVKTIVHAHNG- 838
Cdd:COG2972 348 AIEHGIEPKEgggtIRISIRKEGDRLVITVEDNGVgMPEEKLEKLLEELS-------SKGEGRGIGLRNVRERLKLYYGe 420
|
170 180
....*....|....*....|.
gi 315027614 839 ----KMEMTIGRGkTLVRIYL 855
Cdd:COG2972 421 eyglEIESEPGEG-TTVTIRI 440
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
754-855 |
4.54e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 43.16 E-value: 4.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 754 IEQALFNLIENAFRHGEndlpvklnvyqgkeqtvfeiENHGEIPLKQFQKIQLNLSGTNE--------------VPVD-- 817
Cdd:cd16918 1 LIQVFLNLVRNAAQALA--------------------GSGGEIILRTRTQRQVTLGHPRHrlalrvsvidngpgIPPDlq 60
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 315027614 818 ----------SKNGLGIGLSIVKTIVHAHNGKMEMTIGRGKTLVRIYL 855
Cdd:cd16918 61 dtifypmvsgRENGTGLGLAIAQNIVSQHGGVIECDSQPGHTVFSVSL 108
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
760-855 |
1.10e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 41.99 E-value: 1.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 760 NLIENAFRHGENDLPVKLNVYQGKEQTVFEIENHGEIPL-----KQFQKIQLNLSGTNEVpvdsknGLGIGLSIVKTIVH 834
Cdd:cd16923 7 NLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLdfkleKLFERFYRGDNSRNTE------GAGLGLSIAKAIIE 80
|
90 100
....*....|....*....|.
gi 315027614 835 AHNGKMEMTIGRGKTLVRIYL 855
Cdd:cd16923 81 LHGGSASAEYDDNHDLFKVRL 101
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
750-842 |
1.40e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 42.06 E-value: 1.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 750 DPILIEQALFNLIENAFRHGENDLPVKLNVYQGKEQTVFEIENHGE-IPLKQFQKIQLNLSGTNEvPVDSKNGLGIGLSI 828
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSgIPDYALNRVFERFYSLPR-PHSGQKSTGLGLAF 79
|
90
....*....|....
gi 315027614 829 VKTIVHAHNGKMEM 842
Cdd:cd16945 80 VQEVAQLHGGRITL 93
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
751-849 |
2.22e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 41.25 E-value: 2.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 751 PILIEQALFNLIENAFRHGENDLPVKLNVYQGKEQTVFEIENHGE-IPLKQFQKIQLNLSGTNEVpvdsKNGLGIGLSIV 829
Cdd:cd16943 1 PSQLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSgIDPEILGRIFDPFFTTKPV----GEGTGLGLSLS 76
|
90 100
....*....|....*....|..
gi 315027614 830 KTIVHAHNGKMEMT--IGRGKT 849
Cdd:cd16943 77 YRIIQKHGGTIRVAsvPGGGTR 98
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
754-849 |
3.20e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 40.84 E-value: 3.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 754 IEQALFNLIEN---AFRHGE---NDLPVKLNVYQGKEQTVFeIENHGE-IPLKQFQKIQLNLSGTNevpvdsKNGLGIGL 826
Cdd:cd16920 1 IQQVLINLVRNgieAMSEGGcerRELTIRTSPADDRAVTIS-VKDTGPgIAEEVAGQLFDPFYTTK------SEGLGMGL 73
|
90 100
....*....|....*....|....*
gi 315027614 827 SIVKTIVHAHNGKM--EMTIGRGKT 849
Cdd:cd16920 74 SICRSIIEAHGGRLsvESPAGGGAT 98
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
754-849 |
4.68e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 40.39 E-value: 4.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 754 IEQALFNLIENA--FRHGENDLPVKLNVYQGKEQTVFEIENHG-EIPLKQFQKI-----QLNlsgtnevPVDSKNGLGIG 825
Cdd:cd16921 1 LGQVLTNLLGNAikFRRPRRPPRIEVGAEDVGEEWTFYVRDNGiGIDPEYAEKVfgifqRLH-------SREEYEGTGVG 73
|
90 100
....*....|....*....|....*.
gi 315027614 826 LSIVKTIVHAHNGKM--EMTIGRGKT 849
Cdd:cd16921 74 LAIVRKIIERHGGRIwlESEPGEGTT 99
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
754-843 |
6.29e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 40.11 E-value: 6.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 754 IEQALFNLIENAFRHGENDLPVKLNVYQGKEQTVFEIENHGeIPLKQFQKI-----QLNLSGTNEVPvdsknGLGIGLSI 828
Cdd:cd16939 1 MARALDNLLRNALRYAHRTVRIALLVSGGRLTLIVEDDGPG-IPAAARERVfepfvRLDPSRDRATG-----GFGLGLAI 74
|
90
....*....|....*
gi 315027614 829 VKTIVHAHNGKMEMT 843
Cdd:cd16939 75 VHRVALWHGGHVECD 89
|
|
| LytS |
COG3275 |
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms]; |
682-830 |
8.20e-04 |
|
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
Pssm-ID: 442506 [Multi-domain] Cd Length: 352 Bit Score: 42.55 E-value: 8.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 682 IQEESQWLIRMVENLLSITRINMDTMKVNKTaePVEEVIEAV--YKHLRKV-YPDG-QVDIHLPEEV--IFIqadPILIe 755
Cdd:COG3275 184 IREDPEKARELLLKLSDLLRYSLYESDKELV--PLEEELEFLenYLELEKLrFGDRlQVEIDIDEELldLLI---PPLL- 257
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 315027614 756 qaLFNLIENAFRHG----ENDLPVKLNVYQGKEQTVFEIENhgeiplkqfqkiqlnlSGTNEVPVDSKNGLGIGLSIVK 830
Cdd:COG3275 258 --LQPLVENAIKHGisskEGGGTISISIEVEGDRLVIEVEN----------------NGVGIQPKKKKKGSGIGLKNVR 318
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
639-732 |
9.14e-04 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 43.00 E-value: 9.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 639 RSNLLRAVSHDLRTPLTVISGIAETLGigNDLKEETQRKLLKDIQEESQWLIRMVENLLSITRINMDTMKVNKTAEPVEE 718
Cdd:PRK10618 450 RKAFLQNIGDELKQPLQSLAQLAAQLR--QTSDEEQQQPELDQLAEQSDVLVRLVDNIQLLNMLETQDWKPEQELFSLQD 527
|
90
....*....|....
gi 315027614 719 VIEAVykhLRKVYP 732
Cdd:PRK10618 528 LIDEV---LPEVLP 538
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
620-842 |
1.09e-03 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 42.80 E-value: 1.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 620 TELKDEKEQVELENERE----KVRSNLLRAVSHDLRTPLTVISGIAETLGiGNDLKEETQRKLLKDIQEESQWLIRMVEN 695
Cdd:PRK09959 689 TETRDLIHALEVERNKAinatVAKSQFLATMSHEIRTPISSIMGFLELLS-GSGLSKEQRVEAISLAYATGQSLLGLIGE 767
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 696 LLSITRINMDTMKVNKTAEPVEEVIEAVYKHLRKVYPDGQVDIH----LPEEVIfIQADPILIEQALFNLIENAFRHgEN 771
Cdd:PRK09959 768 ILDVDKIESGNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALScsstFPDHYL-VKIDPQAFKQVLSNLLSNALKF-TT 845
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 772 DLPVKLNVyqgkeQTVFEIENHGEIP---------LKQFQKIQLNLSGTNEVPVDSKNGLGIGLSIVKTIVHAHNGKMEM 842
Cdd:PRK09959 846 EGAVKITT-----SLGHIDDNHAVIKmtimdsgsgLSQEEQQQLFKRYSQTSAGRQQTGSGLGLMICKELIKNMQGDLSL 920
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
608-853 |
1.95e-03 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 41.81 E-value: 1.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 608 LVLTQIAVILEQTELKDEKEQVELENEREKVrsnLLRAVSHDLRTPLTVISGIAETlgIGNDLKEETQRKLLKDIQE--E 685
Cdd:COG3920 267 LLLLAAGIRLVITERKRAEEELEASLEEKEL---LLRELHHRVKNNLQVVSSLLRL--QARRADDPEAREALEESQNriQ 341
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 686 SqwlIRMVENLLS----ITRINMDtmkvnktaepveEVIEAVYKHLRKVYPDGQVDIHlpeevifIQADPILI--EQA-- 757
Cdd:COG3920 342 A---LALVHELLYqsedWEGVDLR------------DYLRELLEPLRDSYGGRGIRIE-------LDGPDVELpaDAAvp 399
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 758 ---LFN-LIENAFRHGENDLP---VKLNVYQGKEQTVFEIENHGeiplkqfqkiqlnlSGTNEvPVDSKNGLGIGLSIVK 830
Cdd:COG3920 400 lglILNeLVTNALKHAFLSGEggrIRVSWRREDGRLRLTVSDNG--------------VGLPE-DVDPPARKGLGLRLIR 464
|
250 260
....*....|....*....|...
gi 315027614 831 TIVHAHNGKMEMTIGRGkTLVRI 853
Cdd:COG3920 465 ALVRQLGGTLELDRPEG-TRVRI 486
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
754-849 |
2.23e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 38.63 E-value: 2.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315027614 754 IEQALFNLIENA--F-RHGENDLPVKL-NVYQGKEQTVFEIENHG-EIPLKQFQKI-----QLNLSGTNevpvdSKNGLG 823
Cdd:cd16922 1 LRQILLNLLGNAikFtEEGEVTLRVSLeEEEEDGVQLRFSVEDTGiGIPEEQQARLfepfsQADSSTTR-----KYGGTG 75
|
90 100
....*....|....*....|....*...
gi 315027614 824 IGLSIVKTIVHAHNGKMEMT--IGRGKT 849
Cdd:cd16922 76 LGLAISKKLVELMGGDISVEsePGQGST 103
|
|
| GST_C_GDAP1L1 |
cd10302 |
C-terminal, alpha helical domain of Ganglioside-induced differentiation-associated protein ... |
598-635 |
2.67e-03 |
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C-terminal, alpha helical domain of Ganglioside-induced differentiation-associated protein 1-like 1; Glutathione S-transferase (GST) C-terminal domain family, Ganglioside-induced differentiation-associated protein 1-like 1 (GDAP1L1) subfamily; GDAP1L1 is a paralogue of GDAP1 with about 56% sequence identity and 70% similarity. It's function is unknown. Like GDAP1, it does not exhibit GST activity using standard substrates. GDAP1 was originally identified as a highly expressed gene at the differentiated stage of GD3 synthase-transfected cells. More recently, mutations in GDAP1 have been reported to cause both axonal and demyelinating autosomal-recessive Charcot-Marie-Tooth (CMT) type 4A neuropathy. CMT is characterized by slow and progressive weakness and atrophy of muscles. Sequence analysis of GDAP1 shows similarities and differences with GSTs; it appears to contain both N-terminal thioredoxin-fold and C-terminal alpha helical domains of GSTs, however, it also contains additional C-terminal transmembrane domains unlike GSTs. GDAP1 is mainly expressed in neuronal cells and is localized in the mitochondria through its transmembrane domains.
Pssm-ID: 198335 Cd Length: 111 Bit Score: 38.45 E-value: 2.67e-03
10 20 30
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gi 315027614 598 LENDQLNYLKLVLTQIAVILEQTELKDEKEQVELENER 635
Cdd:cd10302 19 LEHDNVNYLKKILGELAMVLDQIEAELEKRKLEYEGQK 56
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