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Conserved domains on  [gi|511334176|gb|EFV38699|]
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hypothetical protein HMPREF0864_03932 [Enterobacteriaceae bacterium 9_2_54FAA]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CpxP_like super family cl01482
CpxP component of the bacterial Cpx-two-component system and related proteins; This family ...
 1-153 4.01e-48

CpxP component of the bacterial Cpx-two-component system and related proteins; This family summarizes bacterial proteins related to CpxP, a periplasmic protein that forms part of a two-component system which acts as a global modulator of cell-envelope stress in gram-negative bacteria. CpxP aids in combating extracytoplasmic protein-mediated toxicity, and may also be involved in the response to alkaline pH. Functioning as a dimer, it inhibits activation of the kinase CpxA, but also plays a vital role in the quality control system of P pili. It has been suggested that CpxP directly interacts with CpxA via its concave polar surface. Another member of this family, Spy, is also a periplasmic protein that may be involved in the response to stress. The homology between CpxP and Spy suggests similar functions. A characteristic 5-residue sequence motif LTXXQ is found repeated twice in many members of this family.


The actual alignment was detected with superfamily member PRK10363:

Pssm-ID: 470220  Cd Length: 166  Bit Score: 153.26  E-value: 4.01e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511334176   1 MRKVTSLAMTFMLAMASTAAFAE----GSQHNG-MLYQSMDHNRMFDGVNLSEHQRQQMRDLMQLARHDLPRVDIAEAET 75
Cdd:PRK10363   1 MRIVTAAVMASTLAVSSLSHAAEvgtgDNWHPGeELTQRSTQSHMFDGISLTEHQRQQMRDLMQQARHEQPPVNVSEMET 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 511334176  76 MHNLVTAEKFDEAAVRQLAEKMAQESINRQVEMAKIRNQMYNLLTPEQKAQLNERYQQRIANWqQQIATMQNTSALKL 153
Cdd:PRK10363  81 MHRLVTAENFDENAVRAQAEKMAQEQVARQVEMAKVRNQMYRLLTPEQQAVLNEKHQQRMEQL-RDVTQWQKSSSLKL 157
 
Name Accession Description Interval E-value
cpxP PRK10363
cell-envelope stress modulator CpxP;
1-153 4.01e-48

cell-envelope stress modulator CpxP;


Pssm-ID: 182410  Cd Length: 166  Bit Score: 153.26  E-value: 4.01e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511334176   1 MRKVTSLAMTFMLAMASTAAFAE----GSQHNG-MLYQSMDHNRMFDGVNLSEHQRQQMRDLMQLARHDLPRVDIAEAET 75
Cdd:PRK10363   1 MRIVTAAVMASTLAVSSLSHAAEvgtgDNWHPGeELTQRSTQSHMFDGISLTEHQRQQMRDLMQQARHEQPPVNVSEMET 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 511334176  76 MHNLVTAEKFDEAAVRQLAEKMAQESINRQVEMAKIRNQMYNLLTPEQKAQLNERYQQRIANWqQQIATMQNTSALKL 153
Cdd:PRK10363  81 MHRLVTAENFDENAVRAQAEKMAQEQVARQVEMAKVRNQMYRLLTPEQQAVLNEKHQQRMEQL-RDVTQWQKSSSLKL 157
CpxP COG3678
Periplasmic chaperone Spy, Spy/CpxP family [Posttranslational modification, protein turnover, ...
 2-139 2.47e-30

Periplasmic chaperone Spy, Spy/CpxP family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442894 [Multi-domain]  Cd Length: 141  Bit Score: 106.99  E-value: 2.47e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511334176   2 RKVTSLAMTFMLAMASTAAFAEGSQHNGMlyQSMDHNRMFDGVNLSEHQRQQMRDLMQLARHDLPRV---DIAEAETMHN 78
Cdd:COG3678    3 LKLLALLLALALALGAASAFAAGPPGGPR--GGRGLRRMLEGLNLTEEQRQQIRAIRQQYRKQMRALrqqLREAREELRA 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 511334176  79 LVTAEKFDEAAVRQLAEKMAQESINRQVEMAKIRNQMYNLLTPEQKAQLNERYQQRIANWQ 139
Cdd:COG3678   81 LLAADKFDEAAVRALADKIAALRAQLAVERAEARNQMYKVLTPEQRAKLAELMQERGEKHG 141
CpxP_like cd09916
CpxP component of the bacterial Cpx-two-component system and related proteins; This family ...
 43-134 6.26e-19

CpxP component of the bacterial Cpx-two-component system and related proteins; This family summarizes bacterial proteins related to CpxP, a periplasmic protein that forms part of a two-component system which acts as a global modulator of cell-envelope stress in gram-negative bacteria. CpxP aids in combating extracytoplasmic protein-mediated toxicity, and may also be involved in the response to alkaline pH. Functioning as a dimer, it inhibits activation of the kinase CpxA, but also plays a vital role in the quality control system of P pili. It has been suggested that CpxP directly interacts with CpxA via its concave polar surface. Another member of this family, Spy, is also a periplasmic protein that may be involved in the response to stress. The homology between CpxP and Spy suggests similar functions. A characteristic 5-residue sequence motif LTXXQ is found repeated twice in many members of this family.


Pssm-ID: 197366 [Multi-domain]  Cd Length: 96  Bit Score: 76.48  E-value: 6.26e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511334176  43 GVNLSEHQRQQMRDLMQLARHDLPRV---DIAEAETMHNLVTAEKFDEAAVRQLAEKMAQESINRQVEMAKIRNQMYNLL 119
Cdd:cd09916    1 GLDLTDEQKAQIKAIRQAARAQMKALreqMRAAREELRALLTADTFDEAAVRALAAEMAELQQELAVERAKARNQIYQVL 80

                         90
                 ....*....|....*
gi 511334176 120 TPEQKAQLNERYQQR 134
Cdd:cd09916   81 TPEQRAKLNELFAKR 95
LTXXQ pfam07813
LTXXQ motif family protein; This protein family includes two copies of a five residue motif is ...
 39-131 1.01e-08

LTXXQ motif family protein; This protein family includes two copies of a five residue motif is found in a number of bacterial proteins bearing similarity to the protein CpxP. This is a periplasmic protein that aids in combating extracytoplasmic protein-mediated toxicity, and may also be involved in the response to alkaline pH. Another member of this family, Spy is also a periplasmic protein that may be involved in the response to stress. The homology between CpxP and Spy may indicate that these two proteins are functionally related.


Pssm-ID: 429675  Cd Length: 97  Bit Score: 50.05  E-value: 1.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511334176   39 RMFDGVNLSEHQRQQMRDLMQLARHDLPRVDIAEAETMHNlvTAEKFDEAAVRQLA--EKMAQESINRQVEMAKIRNQMY 116
Cdd:pfam07813   5 FIKAELKLTDAQRAQLDALRDAARAQAKPLKASCEEMRAM--RKANFDETAPRRLAamEQMLEARLEAVKARAEALKQFY 82

                          90
                  ....*....|....*
gi 511334176  117 NLLTPEQKAQLNERY 131
Cdd:pfam07813  83 AILTPEQKAQFDALG 97
 
Name Accession Description Interval E-value
cpxP PRK10363
cell-envelope stress modulator CpxP;
1-153 4.01e-48

cell-envelope stress modulator CpxP;


Pssm-ID: 182410  Cd Length: 166  Bit Score: 153.26  E-value: 4.01e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511334176   1 MRKVTSLAMTFMLAMASTAAFAE----GSQHNG-MLYQSMDHNRMFDGVNLSEHQRQQMRDLMQLARHDLPRVDIAEAET 75
Cdd:PRK10363   1 MRIVTAAVMASTLAVSSLSHAAEvgtgDNWHPGeELTQRSTQSHMFDGISLTEHQRQQMRDLMQQARHEQPPVNVSEMET 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 511334176  76 MHNLVTAEKFDEAAVRQLAEKMAQESINRQVEMAKIRNQMYNLLTPEQKAQLNERYQQRIANWqQQIATMQNTSALKL 153
Cdd:PRK10363  81 MHRLVTAENFDENAVRAQAEKMAQEQVARQVEMAKVRNQMYRLLTPEQQAVLNEKHQQRMEQL-RDVTQWQKSSSLKL 157
cpxP PRK12751
periplasmic stress adaptor protein CpxP; Reviewed
 1-152 2.58e-43

periplasmic stress adaptor protein CpxP; Reviewed


Pssm-ID: 171704  Cd Length: 162  Bit Score: 140.67  E-value: 2.58e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511334176   1 MRKVTSLAMTFMLAMASTAAFA-------EGSQHNGMLYQSMD----HNRMFDGVNLSEHQRQQMRDLMQLARHDLPRVD 69
Cdd:PRK12751   1 MRKVTTLVMASMFVLGSSAAFAadntkvtEGYHGDGKMMMNKKgdrgHHNMFDGINLTEQQRQQMRDLMRQSHQSQPRLD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511334176  70 IAEAETMHNLVTAEKFDEAAVRQLAEKMAQESINRQVEMAKIRNQMYNLLTPEQKAQLNERYQQRIANWQQQIATmQNTS 149
Cdd:PRK12751  81 LEDREAMHKLITADKFDEAAVRAQAEKMSQNQIERHVEMAKVRNQMYNLLTPEQKEALNKKHQERIEKLQQKPAA-QPSS 159


                 ...
gi 511334176 150 ALK 152
Cdd:PRK12751 160 AQK 162
CpxP COG3678
Periplasmic chaperone Spy, Spy/CpxP family [Posttranslational modification, protein turnover, ...
 2-139 2.47e-30

Periplasmic chaperone Spy, Spy/CpxP family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442894 [Multi-domain]  Cd Length: 141  Bit Score: 106.99  E-value: 2.47e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511334176   2 RKVTSLAMTFMLAMASTAAFAEGSQHNGMlyQSMDHNRMFDGVNLSEHQRQQMRDLMQLARHDLPRV---DIAEAETMHN 78
Cdd:COG3678    3 LKLLALLLALALALGAASAFAAGPPGGPR--GGRGLRRMLEGLNLTEEQRQQIRAIRQQYRKQMRALrqqLREAREELRA 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 511334176  79 LVTAEKFDEAAVRQLAEKMAQESINRQVEMAKIRNQMYNLLTPEQKAQLNERYQQRIANWQ 139
Cdd:COG3678   81 LLAADKFDEAAVRALADKIAALRAQLAVERAEARNQMYKVLTPEQRAKLAELMQERGEKHG 141
PRK10455 PRK10455
periplasmic protein; Reviewed
 1-136 2.26e-25

periplasmic protein; Reviewed


Pssm-ID: 182473  Cd Length: 161  Bit Score: 94.87  E-value: 2.26e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511334176   1 MRKVTSL--AMTFMLAMASTAAFAE-----GSQHNGMLYQ----SMDHNRMFDGVNLSEHQRQQMRDLMQLARHDLPRVD 69
Cdd:PRK10455   1 MRKLTALfvASTLALGAANLAHAADtttapPADAKPMMHHkgkfGPHHDMMFKGLNLTDAQKQQIRDIMKAQRDQMKRPP 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 511334176  70 IAEAETMHNLVTAEKFDEAAVRQLAEKMAQESINRQVEMAKIRNQMYNLLTPEQKAQLNERYQQRIA 136
Cdd:PRK10455  81 LEERRAMHDIIASDTFDKAKAEAQITKMEAQRKARMLAHMETQNKIYNVLTPEQKKQFNANFEKRLT 147
CpxP_like cd09916
CpxP component of the bacterial Cpx-two-component system and related proteins; This family ...
 43-134 6.26e-19

CpxP component of the bacterial Cpx-two-component system and related proteins; This family summarizes bacterial proteins related to CpxP, a periplasmic protein that forms part of a two-component system which acts as a global modulator of cell-envelope stress in gram-negative bacteria. CpxP aids in combating extracytoplasmic protein-mediated toxicity, and may also be involved in the response to alkaline pH. Functioning as a dimer, it inhibits activation of the kinase CpxA, but also plays a vital role in the quality control system of P pili. It has been suggested that CpxP directly interacts with CpxA via its concave polar surface. Another member of this family, Spy, is also a periplasmic protein that may be involved in the response to stress. The homology between CpxP and Spy suggests similar functions. A characteristic 5-residue sequence motif LTXXQ is found repeated twice in many members of this family.


Pssm-ID: 197366 [Multi-domain]  Cd Length: 96  Bit Score: 76.48  E-value: 6.26e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511334176  43 GVNLSEHQRQQMRDLMQLARHDLPRV---DIAEAETMHNLVTAEKFDEAAVRQLAEKMAQESINRQVEMAKIRNQMYNLL 119
Cdd:cd09916    1 GLDLTDEQKAQIKAIRQAARAQMKALreqMRAAREELRALLTADTFDEAAVRALAAEMAELQQELAVERAKARNQIYQVL 80

                         90
                 ....*....|....*
gi 511334176 120 TPEQKAQLNERYQQR 134
Cdd:cd09916   81 TPEQRAKLNELFAKR 95
cpxP PRK12750
periplasmic repressor CpxP; Reviewed
 4-147 2.92e-11

periplasmic repressor CpxP; Reviewed


Pssm-ID: 183722 [Multi-domain]  Cd Length: 170  Bit Score: 58.32  E-value: 2.92e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511334176   4 VTSLAMTFMLAMASTAAFAEGSQHNGMLYQ--SMDHNRMFDGVNLSEHQRQQMRDLMQLARHDLPRVDI----------- 70
Cdd:PRK12750   9 LAAVVLPLTLGTASAFAFGGKGDHKGGDGEcgMGMDRGIMRQLDLTDAQKEQLKEMREANRAEMKAKYSgnreqshaemk 88

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 511334176  71 AEAETMHNLVTAEKFDEAAVRQLAEKMAQESINRQVEMAKIRNQMYNLLTPEQKAQLNERYQQRIANWQQQIATMQN 147
Cdd:PRK12750  89 AHHAKVQALVLADDFDEAAANDLAKQMVEKQVERRVKMLEKRHQMLSILTPEQKAKFQELQQERMQECQDKMHKRMK 165
LTXXQ pfam07813
LTXXQ motif family protein; This protein family includes two copies of a five residue motif is ...
 39-131 1.01e-08

LTXXQ motif family protein; This protein family includes two copies of a five residue motif is found in a number of bacterial proteins bearing similarity to the protein CpxP. This is a periplasmic protein that aids in combating extracytoplasmic protein-mediated toxicity, and may also be involved in the response to alkaline pH. Another member of this family, Spy is also a periplasmic protein that may be involved in the response to stress. The homology between CpxP and Spy may indicate that these two proteins are functionally related.


Pssm-ID: 429675  Cd Length: 97  Bit Score: 50.05  E-value: 1.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511334176   39 RMFDGVNLSEHQRQQMRDLMQLARHDLPRVDIAEAETMHNlvTAEKFDEAAVRQLA--EKMAQESINRQVEMAKIRNQMY 116
Cdd:pfam07813   5 FIKAELKLTDAQRAQLDALRDAARAQAKPLKASCEEMRAM--RKANFDETAPRRLAamEQMLEARLEAVKARAEALKQFY 82

                          90
                  ....*....|....*
gi 511334176  117 NLLTPEQKAQLNERY 131
Cdd:pfam07813  83 AILTPEQKAQFDALG 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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