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Conserved domains on  [gi|321466770|gb|EFX77764|]
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hypothetical protein DAPPUDRAFT_53934, partial [Daphnia pulex]

Protein Classification

ANAPC4_WD40 and ANAPC4 domain-containing protein( domain architecture ID 10583931)

ANAPC4_WD40 and ANAPC4 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANAPC4 pfam12896
Anaphase-promoting complex, cyclosome, subunit 4; Apc4 is one of the larger of the subunits of ...
 109-307 4.42e-56

Anaphase-promoting complex, cyclosome, subunit 4; Apc4 is one of the larger of the subunits of the anaphase-promoting complex or cyclosome. This family represents the long domain downstream of the WD40 repeat/s that are present on the Apc4 subunits. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. Results in C.elegans show that the primary essential role of the spindle assembly checkpoint is not in the chromosome segregation process itself but rather in delaying anaphase onset until all chromosomes are properly attached to the spindle. the APC/C is likely to be required for all metaphase-to-anaphase transitions in a multicellular organizm.


:

Pssm-ID: 463744  Cd Length: 203  Bit Score: 181.64  E-value: 4.42e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321466770  109 LLMTVETPLITHCLKELYGLGFLYRQITGLMDCLISAQKALQEAWEDALVDLESKMVRYES----NDGKSSLSVDLMELL 184
Cdd:pfam12896   1 HLLPLDLPFLSSSGRELHLLASKSSQLQSLLRYINQTLKEMQEEWKNARELPDRKLRNLEDllkeQGGESSIVQELYHLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321466770  185 MFGHAGIKLEKFLVTDLTDKGLKRIGQAVELSYSNMQKLLIKHIVCGNYQLSHYLTQLCGLAKQEDRFSCLGLQVNSCLA 264
Cdd:pfam12896  81 LTGHPSPPLKEFLVNQLGERGLKRWEKAVESSYENIRKLVHEHLLPALERLIILLSELRGLAKWHERYEILGLDPELIDE 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 321466770  265 AYRAAGSFTAKTAELQQVIDGSVKYLKTFFRWLYVTILRLSDE 307
Cdd:pfam12896 161 LLDTAGSLLLKAHELLQVINEELKLFKAFFRWLRYVIDRLADE 203
 
Name Accession Description Interval E-value
ANAPC4 pfam12896
Anaphase-promoting complex, cyclosome, subunit 4; Apc4 is one of the larger of the subunits of ...
 109-307 4.42e-56

Anaphase-promoting complex, cyclosome, subunit 4; Apc4 is one of the larger of the subunits of the anaphase-promoting complex or cyclosome. This family represents the long domain downstream of the WD40 repeat/s that are present on the Apc4 subunits. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. Results in C.elegans show that the primary essential role of the spindle assembly checkpoint is not in the chromosome segregation process itself but rather in delaying anaphase onset until all chromosomes are properly attached to the spindle. the APC/C is likely to be required for all metaphase-to-anaphase transitions in a multicellular organizm.


Pssm-ID: 463744  Cd Length: 203  Bit Score: 181.64  E-value: 4.42e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321466770  109 LLMTVETPLITHCLKELYGLGFLYRQITGLMDCLISAQKALQEAWEDALVDLESKMVRYES----NDGKSSLSVDLMELL 184
Cdd:pfam12896   1 HLLPLDLPFLSSSGRELHLLASKSSQLQSLLRYINQTLKEMQEEWKNARELPDRKLRNLEDllkeQGGESSIVQELYHLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321466770  185 MFGHAGIKLEKFLVTDLTDKGLKRIGQAVELSYSNMQKLLIKHIVCGNYQLSHYLTQLCGLAKQEDRFSCLGLQVNSCLA 264
Cdd:pfam12896  81 LTGHPSPPLKEFLVNQLGERGLKRWEKAVESSYENIRKLVHEHLLPALERLIILLSELRGLAKWHERYEILGLDPELIDE 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 321466770  265 AYRAAGSFTAKTAELQQVIDGSVKYLKTFFRWLYVTILRLSDE 307
Cdd:pfam12896 161 LLDTAGSLLLKAHELLQVINEELKLFKAFFRWLRYVIDRLADE 203
 
Name Accession Description Interval E-value
ANAPC4 pfam12896
Anaphase-promoting complex, cyclosome, subunit 4; Apc4 is one of the larger of the subunits of ...
 109-307 4.42e-56

Anaphase-promoting complex, cyclosome, subunit 4; Apc4 is one of the larger of the subunits of the anaphase-promoting complex or cyclosome. This family represents the long domain downstream of the WD40 repeat/s that are present on the Apc4 subunits. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. Results in C.elegans show that the primary essential role of the spindle assembly checkpoint is not in the chromosome segregation process itself but rather in delaying anaphase onset until all chromosomes are properly attached to the spindle. the APC/C is likely to be required for all metaphase-to-anaphase transitions in a multicellular organizm.


Pssm-ID: 463744  Cd Length: 203  Bit Score: 181.64  E-value: 4.42e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321466770  109 LLMTVETPLITHCLKELYGLGFLYRQITGLMDCLISAQKALQEAWEDALVDLESKMVRYES----NDGKSSLSVDLMELL 184
Cdd:pfam12896   1 HLLPLDLPFLSSSGRELHLLASKSSQLQSLLRYINQTLKEMQEEWKNARELPDRKLRNLEDllkeQGGESSIVQELYHLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321466770  185 MFGHAGIKLEKFLVTDLTDKGLKRIGQAVELSYSNMQKLLIKHIVCGNYQLSHYLTQLCGLAKQEDRFSCLGLQVNSCLA 264
Cdd:pfam12896  81 LTGHPSPPLKEFLVNQLGERGLKRWEKAVESSYENIRKLVHEHLLPALERLIILLSELRGLAKWHERYEILGLDPELIDE 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 321466770  265 AYRAAGSFTAKTAELQQVIDGSVKYLKTFFRWLYVTILRLSDE 307
Cdd:pfam12896 161 LLDTAGSLLLKAHELLQVINEELKLFKAFFRWLRYVIDRLADE 203
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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