|
Name |
Accession |
Description |
Interval |
E-value |
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
1-434 |
0e+00 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 796.07 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 1 MAQHTPATSRAGTFGAILRVTSGNFLEQFDFFLFGFYATYIAKTFFPAESEFASLMLTFAVFGSGFLMRPVGAIVLGAYI 80
Cdd:PRK15075 1 MSTMTPAASRESKARAILRVTSGNFLEMFDFFLFGFYATAIAKTFFPAGNEFASLMLTFAVFGAGFLMRPLGAIVLGAYI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 81 DRIGRRKGLMVTLAIMGCGTLLIALVPGYQTIGLAAPALVLLGRLLQGFSAGVELGGVSVYLSEIATPGNKGFYTSWQSA 160
Cdd:PRK15075 81 DRVGRRKGLIVTLSIMASGTLLIAFVPGYATIGLAAPLLVLLGRLLQGFSAGVELGGVSVYLAEIATPGRKGFYTSWQSA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 161 SQQVAIVVAALIGYSLNITLGHDAISEWGWRIPFFIGCMIIPLIFVLRRSLQETEAFLQRKHRPDTREIFATIAKNWRII 240
Cdd:PRK15075 161 SQQVAVVFAALLGYLLNQWLSPAQMAEWGWRIPFLIGCLIVPFIFLIRRSLEETEEFLARKHRPSMREIFRSLAANWRIV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 241 TAGTLLVAMTTTTFYFITVYTPTYGRTVLNLSARDSLIVTMLVGVSNFIWLPIGGAISDRIGRRAVLMGITLLALITTWP 320
Cdd:PRK15075 241 LAGMLMVAMTTVSFYLITVYTPTFGKTVLHLSAADSLLVTLCVGVSNFIWLPIGGALSDRIGRRPVLIAFTVLAILTAYP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 321 VMQWLTAAPDFTRMTLVLLWFSFFFGMYNGAMVAALTEVMPVYVRTVGFSLAFSLATAIFGGLTPAISTALVKLTGDKSS 400
Cdd:PRK15075 321 ALSWLVAAPSFARMLAVELWLSFLYGSYNGAMVVALTEVMPAEVRTAGFSLAYSLATAIFGGFTPAISTWLIHVTGDKAA 400
|
410 420 430
....*....|....*....|....*....|....
gi 322634933 401 PGWWLMCAALCGLAATAMLFVRLSRGYIAAENKA 434
Cdd:PRK15075 401 PGYWLSFAAVCGLIATLVLYRRRGARLQAAEAAA 434
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
17-423 |
0e+00 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 556.22 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 17 ILRVTSGNFLEQFDFFLFGFYATYIAKTFFPAESEFASLMLTFAVFGSGFLMRPVGAIVLGAYIDRIGRRKGLMVTLAIM 96
Cdd:cd17368 1 ILAATSGNALEFFDFGVYGFFAVYIGRLFFPSGSEFASLLLTFATFGVGFFMRPIGAIVLGAYADRIGRKPAMTLTLAIM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 97 GCGTLLIALVPGYQTIGLAAPALVLLGRLLQGFSAGVELGGVSVYLSEIATPGNKGFYTSWQSASQQVAIVVAALIGYSL 176
Cdd:cd17368 81 ALGTLLIALAPTYATIGIAAPLLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIVAGALVGYLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 177 NITLGHDAISEWGWRIPFFIGCMIIPLIFVLRRSLQETEAFLQRKHRPDTREIFATIAKNWRIITAGTLLVAMTTTTFYF 256
Cdd:cd17368 161 SLTLTAEALAEWGWRIPFFIGLLIIPLGLWLRRSLEETEAFLERKARPTRRELFALLANNRRIILLGMLLVAGSTVTFYF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 257 ITVYTPTYGRTVLNLSARDSLIVTMLVGVSNFIWLPIGGAISDRIGRRAVLMGITLLALITTWPVMQWLTAAPDFTRMTL 336
Cdd:cd17368 241 TTVYTPTYAKTVLGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLAALVTLYPVFAWLTAAPSFGRLLL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 337 VLLWFSFFFGMYNGAMVAALTEVMPVYVRTVGFSLAFSLATAIFGGLTPAISTALVKLTGDKSSPGWWLMCAALCGLAAT 416
Cdd:cd17368 321 VLLVLSFFFGMYGGAMVVALVELFPVRVRSTGFSLVYALAVAIFGGFAQFIVTWLIELTGSPLAPAWYLMGAALLGLLAT 400
|
....*..
gi 322634933 417 AMLFVRL 423
Cdd:cd17368 401 LMLRETA 407
|
|
| 2A0106 |
TIGR00883 |
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the ... |
23-413 |
4.62e-163 |
|
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the major facilitator superfamily (pfam00083), including citrate-H+ symporters, dicarboxylate:H+ symporters, the proline/glycine-betaine transporter ProP, etc. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273320 [Multi-domain] Cd Length: 394 Bit Score: 464.44 E-value: 4.62e-163
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 23 GNFLEQFDFFLFGFYATYIAKTFFP-AESEFASLMLTFAVFGSGFLMRPVGAIVLGAYIDRIGRRKGLMVTLAIMGCGTL 101
Cdd:TIGR00883 1 GNAVEWFDFYLYGFAAVLVFHTFFPpSGDPLVALLATFATFAAGFLARPLGAIVFGHFGDRIGRKKTLVITLLMMGIGTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 102 LIALVPGYQTIGLAAPALVLLGRLLQGFSAGVELGGVSVYLSEIATPGNKGFYTSWQSASQQVAIVVAALIGYSLNITLG 181
Cdd:TIGR00883 81 LIGLLPSYATIGIWAPILLLLARLIQGFSLGGEWGGAALYLAEYAPPGKRGFYGSFQQVGAPVGLLLAALTVLLLSYLLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 182 HDAISEWGWRIPFFIGCMIIPLIFVLRRSLQETEAFLQR--KHRPDTREIFATIAKNWRIITAGTLLVAMTTTTFYFITV 259
Cdd:TIGR00883 161 DDALLEWGWRIPFLVSAVLVLIGLYLRRNLEETPVFEKAqeKHKKKRGPIAETLTKHRKPFLLGLGLVIATTTTFYLITT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 260 YTPTYGRTVLNLSARDSLIVTMLVGVSNFIWLPIGGAISDRIGRRAVLMGITLLALITTWPVMQWLTAAPDFTRMTLVLL 339
Cdd:TIGR00883 241 YLPTYLTQTLGLSANSALLVLMLSLILFFITIPLSGALSDRIGRRPVLIIFTVLAALLAVPLLMALLDSGSFTLFFFLVL 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 322634933 340 WFSFFFGMYNGAMVAALTEVMPVYVRTVGFSLAFSLATAIFGGLTPAISTALVKLTGDKSSPGWWLMCAALCGL 413
Cdd:TIGR00883 321 GMALIGGMYTGPMGSFLPELFPTEVRYTGASLAYNLAGAIFGGFAPYIAAALVAMTGDWYAIGYYLAALALIGL 394
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
17-422 |
2.09e-97 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 297.67 E-value: 2.09e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 17 ILRVTSGNFLEQFDFFLFGFYATYIAKTFFPAESEFASLMLTFAVFGSGFLMRPVGAIVLGAYIDRIGRRKGLMVTLAIM 96
Cdd:cd17367 1 ILGGSVGNLVEWYDWYVYAAFALYFAPQFFPSGDPTVALLSTAAVFAVGFLMRPIGGWLFGRLADRIGRRAALTLSVSLM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 97 GCGTLLIALVPGYQTIGLAAPALVLLGRLLQGFSAGVELGGVSVYLSEIATPGNKGFYTSWQSASQQVAIVVAALIGYSL 176
Cdd:cd17367 81 AAGSLVIAVTPTYATIGIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 177 NITLGHDAISEWGWRIPFFIGCMIIPLIFVLRRSLQETEAFLQRKHRPDTRE-IFATIAKNWRIITAGTLLVAMTTTTFY 255
Cdd:cd17367 161 QHTLGEDQMAAWGWRIPFLLGGVLAVVVLWLRRGLEETESFEAIAESNEASAgTLRELRRHPRELLLVVGLTAGGTLAFY 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 256 FITVYTPTYGRTVLNLSARDSLIVTMLVGVSNFIWLPIGGAISDRIGRRAVLMGITLLALITTWPVMQWLTAAPDFTRMT 335
Cdd:cd17367 241 TWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSALDHTDSPYTAF 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 336 LVLLWFSFFFGMYNGAMVAALTEVMPVYVRTVGFSLAFSLATAIFGGLTPAISTALVKLTGdksSPGWWLMCAALCGLAA 415
Cdd:cd17367 321 ALVLVGLVFLSGYTSINAVVKAELFPTHVRALGVGLPYALAVAIFGGTAPYVALWLKSIGH---EWVFFWYVAGLIAISL 397
|
....*..
gi 322634933 416 TAMLFVR 422
Cdd:cd17367 398 VVYLRMP 404
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
23-417 |
3.16e-89 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 276.72 E-value: 3.16e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 23 GNFLEQFDFFLFGFYA-TYIAKTFFPAESEFASLMLTFAVFGSGFLMRPVGAIVLGAYIDRIGRRKGLMVTLAIMGCGTL 101
Cdd:cd17369 10 GTAIEWYDFFIYGTAAaLVFNKLFFPAVDPAAGTLAAFATFGVGFLARPLGGVVFGHFGDRIGRKKTLVLTLLLMGIATF 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 102 LIALVPGYQTIGLAAPALVLLGRLLQGFSAGVELGGVSVYLSEIATPGNKGFYTSWQSASQQVAIVVAALIGYSLNITLG 181
Cdd:cd17369 90 LIGLLPTYAQIGILAPILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATGVFLLLSALLS 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 182 HDAISEWGWRIPFFIGCMIIPLIFVLRRSLQETEAFLQRKHRPDTR--EIFATIAKNWRIITAGTLLVAMTTTTFYFITV 259
Cdd:cd17369 170 DEAFLSWGWRIPFLLSAVLVAVGLYIRLRLEETPVFRRAKEAGQVVraPLVEVLRRHWRALLLAIGLRLAENVLFYLFTT 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 260 YTPTYGRTVLNLSARDSLIVTMLVGVSNFIWLPIGGAISDRIGRRAVLMGITLLALITTWPVMQWLTAAPDFTRMTLVLL 339
Cdd:cd17369 250 FALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLDTGSTWLIVLAAVV 329
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 322634933 340 WFSFFFGMYNGAMVAALTEVMPVYVRTVGFSLAFSLATAIFGGLTPAISTALVKLTGDKSSPGWWLMCAALCGLAATA 417
Cdd:cd17369 330 VLGVLHGMMYGPQAAFLAELFPTRVRYTGASLGYQLGAILGGGFAPLIATALVAATGSWWPVALYLAALAVISLVAAL 407
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
23-420 |
5.57e-71 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 228.40 E-value: 5.57e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 23 GNFLEQFDFFLFGFYATYIAKTFFPAESEFASLMLTFAVFGSGFLMRPVGAIVLGAYIDRIGRRKGLMVTLAIMGCGTLL 102
Cdd:cd17366 7 GNAMEWFDFGVYGYLAVTIGKVFFPGGDPTAQLLATFATFAVAFLVRPLGGLVFGPLGDKYGRQKVLAITIILMAASTFC 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 103 IALVPGYQTIGLAAPALVLLGRLLQGFSAGVELGGVSVYLSEIATPGNKGFYTSWQSASQQVAIVVAALIGYSLNITLGH 182
Cdd:cd17366 87 IGLLPTYATIGVWAPILLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGSWLEFGTLAGFILGAGLVTLLTLLLTE 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 183 DAISEWGWRIPFFIGCMIIPLIFVLRRSLqeteaflqrkhrpdtreifatiaknwrIITAGtlLVAMTTTTFYFITVYTP 262
Cdd:cd17366 167 AQMLDWGWRIPFLIAAPLGLVGLYLRRPL---------------------------LICIG--LVLVFNVTNYMLLSYMP 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 263 TYGRTVLNLSARDSLIVTMLVGVSNFIWLPIGGAISDRIGRRAVLMGITLLALITTWPVMQWLTAAPDFTRMTLVLLwFS 342
Cdd:cd17366 218 SYLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYAAGLAGLLVLAVPAFLLMNSGSIAAIFIGLLV-LG 296
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 322634933 343 FFFGMYNGAMVAALTEVMPVYVRTVGFSLAFSLATAIFGGLTPAISTALVKLTGDKSSPGWWLMCAALCGLAATAMLF 420
Cdd:cd17366 297 LLLSCYTATMASTLPALFPTHVRYSALAIAFNISVSLFGGTTPLVASWLVSATGNPLMPAYYLMVAAVVGLVAVLFLT 374
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
16-419 |
1.12e-61 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 205.81 E-value: 1.12e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 16 AILRVTSGNFLEQFDFFLFGFYATYIAKTFFPAESEFASLMLTFAVFGSGFLMRPVGAIVLGAYIDRIGRRKGLMVTLAI 95
Cdd:PRK10406 23 AIVGASSGNLVEWFDFYVYSFCSLYFAHIFFPSGNTTTQLLQTAGVFAAGFLMRPIGGWLFGRIADKHGRKKSMLISVCM 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 96 MGCGTLLIALVPGYQTIGLAAPALVLLGRLLQGFSAGVELGGVSVYLSEIATPGNKGFYTSWQSASQQVAIVVAALIGYS 175
Cdd:PRK10406 103 MCFGSLVIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYASFQYVTLIGGQLLALLVVVV 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 176 LNITLGHDAISEWGWRIPFFIGCMIIPLIFVLRRSLQETEAFLQRKHRPDTReiFATIAKNWRIITAGTLLVAMTTTTFY 255
Cdd:PRK10406 183 LQQTLEDAELREWGWRIPFALGAVLAVVALWLRRQLDETSQQETRALKEAGS--LKGLWRNRRAFIMVLGFTAAGSLCFY 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 256 FITVYTPTYgrtVLNLSARDSLIVTMLVGVSNFIWL---PIGGAISDRIGRRAVLMGITLLALITTWPVMQWLTAAPD-- 330
Cdd:PRK10406 261 TFTTYMQKY---LVNTAGMHANVASGIMTAALFVFMliqPLIGALSDKIGRRTSMLCFGSLAALFTVPILSALQNVSSpy 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 331 --FTRMTLVLLWFSFFFGMyNGAMVAaltEVMPVYVRTVGFSLAFSLATAIFGGLTPAISTALvKLTGDKSSPGWWLMCA 408
Cdd:PRK10406 338 aaFGLVMCALLIVSFYTSI-SGILKA---EMFPAQVRALGVGLSYAVANALFGGSAEYVALSL-KSIGMETAFFWYVTLM 412
|
410
....*....|.
gi 322634933 409 ALCGLAATAML 419
Cdd:PRK10406 413 AVVAFLVSLML 423
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
17-417 |
1.03e-59 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 198.59 E-value: 1.03e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 17 ILRVTSGNFLEQFDFFLFGFYATYIAKTFfpaeSEFASLMLTFAVFGSGFLMRPVGAIVLGAYIDRIGRRKGLMVTLAIM 96
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEF----SLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 97 GCGTLLIALVPGyqtiglaaPALVLLGRLLQGFSAGVELGGVSVYLSEIATPGNKGFYTSWQSASQQVAIVVAALIGYSL 176
Cdd:cd17316 77 GLATLLIGLLPT--------PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 177 NITLGHDaiseWGWRIPFFIGCMIIPLIFVLRRSlqeteaflqrkhrpdtreifatiaknwriITAGTLLVAMTTTTFYF 256
Cdd:cd17316 149 IPLLSGD----WGWRILFLIGALPALLALLLRRR-----------------------------TLLLILLWFFISFGYYG 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 257 ITVYTPTYGRTVLNLSARDSLIVTMLVGVSNFIWLPIGGAISDRIGRRAVLMGITLLALITTWPVMQWLTAapDFTRMTL 336
Cdd:cd17316 196 LTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSG--SPTLLLL 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 337 VLLWFSFFFGMYNGAMVAALTEVMPVYVRTVGFSLAFSLATAIFGGLTPAISTALVKlTGDKSSPGWWLMCAALCGLAAT 416
Cdd:cd17316 274 LLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLAS-TGGTGVPALILALLAIVALIVA 352
|
.
gi 322634933 417 A 417
Cdd:cd17316 353 L 353
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
16-419 |
9.37e-59 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 199.94 E-value: 9.37e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 16 AILRVTSGNFLEQFDFFLFGFYATYIAKTFFPAESEFASLMLTFAVFGSGFLMRPVGAIVLGAYIDRIGRRKGLMVTLAI 95
Cdd:PRK10642 17 AITAASLGNAMEWFDFGVYGFVAYALGKVFFPGADPSVQMIAALATFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 96 MGCGTLLIALVPGYQTIGLAAPALVLLGRLLQGFSAGVELGGVSVYLSEIATPGNKGFYTSWQSASQQVAIVVAALIGYS 175
Cdd:PRK10642 97 MSISTFCIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAGVVVL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 176 LNITLGHDAISEWGWRIPFFIGCMIIPLIFVLRRSLQETEAFLQR--KHRPDTREI--------FATIA-KNWRIITAGT 244
Cdd:PRK10642 177 ISTIVGEANFLDWGWRIPFFIALPLGIIGLYLRHALEETPAFQQHvdKLEQGDREGlqdgpkvsFKEIAtKHWRSLLTCI 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 245 LLVAMTTTTFYFITVYTPTYGRTVLNLSARDSLIVTMLVGVSNFIWLPIGGAISDRIGRRAVLMGITLLALITTWPVMQw 324
Cdd:PRK10642 257 GLVIATNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMIGMLFVQPVMGLLSDRFGRRPFVILGSVALFVLAIPAFI- 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 325 LTAAPDFTRMTLVLLWFSFFFGMYNGAMVAALTEVMPVYVRTVGFSLAFSLATAIfGGLTPAISTALVKLTGDKSSPGWW 404
Cdd:PRK10642 336 LINSNVIGLIFAGLLMLAVILNCFTGVMASTLPAMFPTHIRYSALAAAFNISVLV-AGLTPTLAAWLVESTQNLMMPAYY 414
|
410
....*....|....*
gi 322634933 405 LMCAALCGLAATAML 419
Cdd:PRK10642 415 LMVVAVIGLITGVTM 429
|
|
| PRK09952 |
PRK09952 |
shikimate transporter; Provisional |
2-396 |
5.91e-43 |
|
shikimate transporter; Provisional
Pssm-ID: 182163 [Multi-domain] Cd Length: 438 Bit Score: 156.43 E-value: 5.91e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 2 AQHTPATSRAGTfgAILRVTSGNFLEQFDFFLFGFYATYIAKT-FFPAESEFASLMLTFAVFGSGFLMRPVGAIVLGAYI 80
Cdd:PRK09952 11 DEGTLSLSRARR--AALGSFAGAVVDWYDFLLYGITAALVFNReFFPQVSPAMGTLAAFATFGVGFLFRPLGGVVFGHFG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 81 DRIGRRKGLMVTLAIMGCGTLLIALVPGYQTIGLAAPALVLLGRLLQGFSAGVELGGVSVYLSEIATPGNKGFYTSWQSA 160
Cdd:PRK09952 89 DRLGRKRMLMLTVWMMGIATALIGLLPSFSTIGWWAPVLLVTLRAIQGFAVGGEWGGAALLAVESAPKNKKAFYSSGVQV 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 161 SQQVAIVVAALIGYSLNITLGHDAISEWGWRIPFFIGCMIIPLIFVLRRSLQETEAFLQRK----HRPDTREIFATIAKN 236
Cdd:PRK09952 169 GYGVGLLLSTGLVSLISMMTTDEQFLSWGWRIPFLFSIVLVLIALWVRNGMEESAEFEQQQheqaAAKKRIPVIEALLRH 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 237 WRIITAGTLLVAMTTTTFYFITVYTPTYGRTVLNLSARDSLIVTMLVGVSNFIWLPIGGAISDRIGRRAVLMGITLLALI 316
Cdd:PRK09952 249 PGAFLKIIALRLCELLTMYIVTAFALNYSTQNLGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRVYITGALIGTL 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 317 TTWPVMQWLTAapdftRMTLVLLWFSFFFGMYNGAMVAAL-----TEVMPVYVRTVGFSLAFSLATAIFGGLTPAISTAL 391
Cdd:PRK09952 329 SAFPFFMALEA-----QSIFWIVFFSIMLANIAHDMVVCVqqpmfTEMFGASYRYSGAGVGYQVASVVGGGFTPFIAAAL 403
|
....*
gi 322634933 392 VKLTG 396
Cdd:PRK09952 404 VTYFG 408
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
20-422 |
4.60e-33 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 128.46 E-value: 4.60e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 20 VTSGNFLEQFDFFLFGFYATYIAKTFFPAESEFASLmltfavFGSGFLMRPVGAIVLGAYIDRIGRRKGLMVTLAIMGCG 99
Cdd:COG2223 10 ATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLL------FAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 100 TLLIALVPGYqtiglaapALVLLGRLLQGFSAGVELGGVSVYLSEIATPGNKGFYTSWQSASQQVAIVVAALIGYSLnit 179
Cdd:COG2223 84 LLLLALAVSY--------WLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLL--- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 180 lghdaISEWGWRIPFFI-GCMIIPLIFVLRRSLQETEAFLQRKHRPDTREIFAtIAKNWRIItAGTLLVAMTTTTFYFIT 258
Cdd:COG2223 153 -----IAAFGWRNAFLIlGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLE-ALRDPRFW-LLSLLYFGTFGSFIGFS 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 259 VYTPTYGRTVLNLSARDSLIVTMLVGVSNFIWLPIGGAISDRIGRRAVLMGITLLALITTWPVMQWLTAAPDFtrmTLVL 338
Cdd:COG2223 226 SWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLF---LVLF 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 339 LWFSFFFGMYNGAMVAALTEVMPVYVRTVGFSLAFsLATAIFGGLTPAISTALVKLTGDKSSPGWWLMCAALCGLAATAM 418
Cdd:COG2223 303 LLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVG-AAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLL 381
|
....
gi 322634933 419 LFVR 422
Cdd:COG2223 382 LYRR 385
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
7-375 |
1.72e-29 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 117.77 E-value: 1.72e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 7 ATSRAGTFGAILRVTSGNFLEQFDFFLFGFYATYIAKTFFpaesefASLMLTFAVFGSGFLMRPVGAIVLGAYIDRIGRR 86
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLG------ASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 87 KGLMVTLAIMGCGTLLIALVPGYqtiglaapALVLLGRLLQGFSAGVELGGVSVYLSEIATPGNKGFYTSWQSASQQVAI 166
Cdd:COG2814 76 RVLLLGLLLFALGSLLCALAPSL--------WLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGP 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 167 VVAALIGYSLnitlghdaISEWGWRIPFFI-GCMIIPLIFVLRRSLQETEAFLQRKHRPDTREIFAtiaknWRIITAGTL 245
Cdd:COG2814 148 ALGPLLGGLL--------ADLFGWRWVFLVnAVLALLALLLLLRLLPESRPAARARLRGSLRELLR-----RPRLLLLLL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 246 LVAMTTTTFYFITVYTPTYGRTVLNLSARDSLIVTMLVGVSNFIWLPIGGAISDRIGRRAVLMGITLLALIttwpVMQWL 325
Cdd:COG2814 215 LAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLAL----GLLLL 290
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 322634933 326 TAAPDFTRMTLVLLWFSFFFGMYNGAMVAALTEVMPVYVRTVGFSLAFSL 375
Cdd:COG2814 291 ALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSA 340
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
26-392 |
6.10e-25 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 105.46 E-value: 6.10e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 26 LEQFDFFLFGFYATYIAKTFFPAESEFASLMLTFAVFGSgflmrpVGAIVLGAYIDRIGRRKGLMVTLAIMGCGTLLIAL 105
Cdd:cd17371 10 LDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGA------IGGILGGILADRFGRVRVLVITILLFAVFTLLCGF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 106 VPGYQTIGLAapalvllgRLLQGFSAGVELGGVSVYLSEIATPGNKGFYTSWQSASQQVAIVVAALigysLNITLGHDAI 185
Cdd:cd17371 84 AQNYWQLLIL--------RALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATL----LAALLFPLLP 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 186 SEWGWRIPFFIGCMIIPLIFVLRRSLQETEAFLQRKHRPDTREIFATIAKNWRIITAGTLLVAMTTTTF-----YFITVY 260
Cdd:cd17371 152 PEIAWRVLFLLGALPALLVLFIRRFVKEPPQWQAARAARRHFADRPSLRELFSPPLLRTTLLASLLATGalggyYGITTW 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 261 TPTYGRTVLNLSARDSLIVTMLVGVSNFIWLPIGGAISDRIGRRAVLMGITLLALITTwPVMQWLTAAPDFTRMTLVLLW 340
Cdd:cd17371 232 LPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISI-LLYFFLPLSPTLILILGFPLG 310
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 322634933 341 FsFFFGMYnGAMVAALTEVMPVYVRTVGFSLAFSLATAIfGGLTPAISTALV 392
Cdd:cd17371 311 F-FASGPF-SGMGAYLTELFPTAVRATAQGFCYNVGRII-GALFPFLVGFLA 359
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
23-422 |
1.43e-24 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 104.18 E-value: 1.43e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 23 GNFLEQFDFFLFGFYATYIAKTFFPAESEFAslmltfAVFGSGFLMRPVGAIVLGAYIDRIGRRKGLMVTLAIMGCGTLL 102
Cdd:COG2271 18 AYFLNYLDRSNLSVAAPPLQADLGLSAAQLG------LLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 103 IALVPGYqtiglaapALVLLGRLLQGFSAGVELGGVSVYLSEIATPGNKGFYTSWQSASQQVAIVVAALIGYSLnitlgh 182
Cdd:COG2271 92 FGFATSF--------WQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWL------ 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 183 daISEWGWRIPFFIGCMIIPLIFVLRrslqeteaflqrkhrpdtreifatiaknwriITAGTLLVAMTTTTFYFITVYTP 262
Cdd:COG2271 158 --LAAFGWRAAFLILGLPGLLLALLR-------------------------------FWLLALAYFLVYFALYGFLTWLP 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 263 TYGRTVLNLSARDSLIVTMLVGVSNFIWLPIGGAISDRIGRRAVLMGITLLALITtwPVMQWLTAAPDFTRMTLVLLWFS 342
Cdd:COG2271 205 TYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAA--LALLLLALLPSPALAIALLFLAG 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 343 FFFGMYNGAMVAALTEVMPVYVRTVGFSLAFSLAtAIFGGLTPAISTALVKLTGdksSPGWWLMCAALCGLAATAMLFVR 422
Cdd:COG2271 283 FGLGGAFGLLWALAAELFPKKARGTASGLVNTFG-FLGGALGPLLVGYLLDATG---YQAAFLLLAALALLAALLALLLL 358
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
20-391 |
6.91e-24 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 103.12 E-value: 6.91e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 20 VTSGNFLEQFDFFLFGFYATYIAKTFFPA-----ESEFASLMLTFAVFGSGFLMRPVGAIVLGAYIDRIGRRKGLMVTLA 94
Cdd:pfam00083 5 AALGGFLFGYDTGVIGAFLTLIDFFKNFGlsksvSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 95 IMGCGTLLIALVPGYQTIGLaapalVLLGRLLQGFSAGVELGGVSVYLSEIATPGNKGFYTSWQSASQQVAIVVAALIGY 174
Cdd:pfam00083 85 LFVIGAVLQGAAKGKWSVYQ-----LIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 175 SLNITLGhdaisEWGWRIPFFIGCMIIPLIFVLRRSLQETEAFLQRKHR---------------PDTREI---------- 229
Cdd:pfam00083 160 GLNKTSN-----SDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRleearevlaklrgvpDVDRELdeikdsleag 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 230 -----------FATIAKNWRIITAGTLLVAMTTTTFYFITVYTPTYGRtvlNLSARDSLIVTMLVGVSNFIWLPIGGAIS 298
Cdd:pfam00083 235 qeaekaswkelFSTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFE---NLGLSDSFLVTIIVGVVNFVFTFIAIFLV 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 299 DRIGRRAVLM----GITLLALITTWPVMQWLTAAPDFTRMTLV-LLWFSFFFGMYNGAMVAAL-TEVMPVYVRTVGFSLA 372
Cdd:pfam00083 312 DRFGRRPLLLlgaaGMAICFVILGIVALLGVSKSDWAGIVAIVfIALFIAFFAMGWGPVPWVIvSELFPLSVRSKAMALA 391
|
410 420
....*....|....*....|..
gi 322634933 373 FS---LATAIFGGLTPAISTAL 391
Cdd:pfam00083 392 TAanwLANFLIGFLFPIITDAI 413
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
5-318 |
1.59e-20 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 91.41 E-value: 1.59e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 5 TPATSRAGTFGAILRVTSGNFLEQFDFFLFGFYATYIAKTFFPAESEFAslmltfAVFGSGFLMRPVGAIVLGAYIDRIG 84
Cdd:COG0477 4 TDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLG------WIVSAYLLGRAIGLLLFGRLGDRYG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 85 RRKGLMVTLAIMGCGTLLIALVPGyqtiglaaPALVLLGRLLQGFSAGVELGGVSVYLSEIATPGNKGFYTSWQSASQQV 164
Cdd:COG0477 78 RKRVLLIGLLLFGLASLLCGLAPS--------PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 165 AIVVAALIGYSLnitlghdaISEWGWRIPFFIGCMIIPLIFVLRRSLQETEAFLQRKHRPDTREIFATIAKNWRIITAGT 244
Cdd:COG0477 150 GLALGPLLGGLL--------VAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLL 221
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 322634933 245 LLVAMTTTTFYFITVYTPTYGRTVLNLSARDSLIVTMLVGVSNFIWLPIGGAISDRIGRRAVLMGITLLALITT 318
Cdd:COG0477 222 LLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
61-422 |
1.33e-17 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 83.78 E-value: 1.33e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 61 VFGSGFLMRPVGAIVLGAYIDRIGRRKGLMVTLAIMGCGTLLIALVPgyqtiglaAPALVLLGRLLQGFSAGVELGGVSV 140
Cdd:cd17325 36 IVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFAT--------SYWQLLLARFLQGLASAAVWPAAMA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 141 YLSEIATPGNKGFYTSWQSASQQVAIVVAALIGYSLnitlghdaISEWGWRIPFFIGCMIIPLIFVLRRSLQETEAFLQR 220
Cdd:cd17325 108 LIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLL--------ADALGYRAPFLVCAALALLALVLALLLLPEPRPPPN 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 221 KHRPDTREIFATIaknWRIITAGTLLVAMTTTTFYFITVYT-----PTYGRTVLNLSARDSLIVTMLVGVSNFIWLPIGG 295
Cdd:cd17325 180 KRAVSAARLRSGL---RLLLRDRRLLALFLAIFVLAFAFGAlepflPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAG 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 296 AISDRIGRRAVLM-GITLLALIttwpvMQWLTAAPDFTRMTLVLLWFSFFFGMYNGAMVAALTEVMPVYVRTVGFSLaFS 374
Cdd:cd17325 257 KLSDRIGRKPLILiGLLLSAVA-----LLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGL-FN 330
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 322634933 375 LATAIFGGLTPAISTALVKLTGDKSSpgwWLMCAALCGLAATAMLFVR 422
Cdd:cd17325 331 TAFSLGMVLGPLLGGFLYDAFGFATP---FLAAAALLLLAAVLFLLLR 375
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
20-375 |
5.21e-16 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 78.61 E-value: 5.21e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 20 VTSGNFLEQFDFFLFGFYATYIAKTFFPAESEFASLMLTFAVFGSGflmrpVGAIVLGAYIDRIGRRKGLMVTLAIMGCG 99
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYA-----LAQPLAGRLSDRFGRRRVLLIGLLLFALG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 100 TLLIALVPGYqtiglaapALVLLGRLLQGFSAGVELGGVSVYLSEIATPGNKGFYTSWQSASQQVAIVVAALIGYSLnit 179
Cdd:pfam07690 76 LLLLLFASSL--------WLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLL--- 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 180 lghdaISEWGWRIPFFI-----GCMIIPLIFVLRRSLQETEAFLQRKHRPDTREIFATIAKNWRIITAGTLLVAMtttTF 254
Cdd:pfam07690 145 -----ASLFGWRAAFLIlailsLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGF---AF 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 255 YFITVYTPTYgRTVLNLSARDSLIVTMLVGVSNFIWLPIGGAISDRIGRRAVLMGITLLALITTWPVMqWLTAAPDFTRM 334
Cdd:pfam07690 217 FGLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLL-LLSLTLSSLWL 294
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 322634933 335 TLVLLWFSFFFGMYNGAMVAALTEVMPVYVRTVGFSLAFSL 375
Cdd:pfam07690 295 LLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTA 335
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
71-419 |
1.58e-14 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 74.51 E-value: 1.58e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 71 VGAIVLGAYIDRIGRRKGLMVTLAIMGCGTLLIALVPGYqtiglaapALVLLGRLLQGFSAGVELGGVSVYLSEIATPGN 150
Cdd:cd17324 49 LGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSF--------ALLLLARALAGLAHGGFWAIAAAYAADLVPPEK 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 151 KGFYTSWQSASQQVAIVVAALIGYSLNitlghdaiSEWGWRIPF-FIGCMIIPLIFVLRRSLQETEAFLQRKHRPDTREI 229
Cdd:cd17324 121 RGRAIGLVFSGLTLGLVLGRPLGGLLG--------QLLGWRAAFlAIAVLALLAALLLWRLLPSLPPKKPGSLGLLSSLL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 230 FATIAKNWRIITAGTLLVAMTTTTFYfitVYTPTYGRTVLNLSARDSLIVTMLVGVSNFIWLPIGGAISDRIGRRAVLMG 309
Cdd:cd17324 193 LLLRNPRLRLAYLITFLLFGGFFALY---TYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIA 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 310 ITLLALITTWPvmqWLTAAPDFTRMTLVLLWFSFFFGMYNGAMVAALTevmpvyVRTVGFSLAFSLATAIF---GGLTPA 386
Cdd:cd17324 270 LLLLAAALLLL---TLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLR------LAPEARGLASSLYLAAYnlgGALGAA 340
|
330 340 350
....*....|....*....|....*....|...
gi 322634933 387 ISTALVKLTGdksSPGWWLMCAALCGLAATAML 419
Cdd:cd17324 341 LGGLVLDHGG---WAGVGWVGAALLLLALLLAL 370
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
6-430 |
3.28e-14 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 74.17 E-value: 3.28e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 6 PATSRAGTFGAILRVTSGNFLEQFDFFLFGFYATYIAKTFFPAESEFASLMLTFAVFgSGFLMRPVGAIVLGAYIDRIGR 85
Cdd:COG2211 1 TAAKKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARL-WDAITDPLIGALSDRTRTRWGR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 86 RKGLMVTLAI-MGCGTLLIALVPGYQTIGLAAPALVLLgrLLQGFSAGVELGGVSVYLSEIAT-PGNKGFYTSWQSASQQ 163
Cdd:COG2211 80 RRPWILIGAIpLALSFVLLFTAPDLSPTGKLIYALVTY--LLLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 164 VAIVVAALIGYSLNITLGHDAISEWGWRIPFFIGCMIIPLIFVLRRSlqeTEAFLQRKHRPDTREIFATIAKN--WRIIT 241
Cdd:COG2211 158 LGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGT---KERPVPEEEKVSLKESLKALLKNrpFLLLL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 242 AGTLLVAMTTTTFYFITVYtptYGRTVLNLSARDSLIVTMLVGVSNFIWLPIGGAISDRIGRRAVLMGITLLALITTwpV 321
Cdd:COG2211 235 LAYLLFFLALALVAALLLY---YFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGL--L 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 322 MQWLTAAPDFTRMTLVLLWFSFFFGMYNGAMVAALTEVMPV-----YVRTVGFSLA-FSLATAIFGGLTPAISTALVKLT 395
Cdd:COG2211 310 LLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYdewktGRRREGLYFGiFTFAIKLGQALAGALAGLLLALF 389
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 322634933 396 GDKSSP------------GWWLMCAALCGLAATAMLFVRLSRGYIAA 430
Cdd:COG2211 390 GYVAGAaqspsaltgirlLFFLLPAVLLLLAALLLLFYPLTRERHAE 436
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
20-419 |
3.23e-13 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 70.53 E-value: 3.23e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 20 VTSGNFLEQFDFFLFGFYATYIAKtFFPAESEFASLMLTFAVFGSGFLMrpvgaIVLGAYIDRIGRRKGLMVTLAIMGCG 99
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQ-SFGLSASQLGLLFALFSLGYALLQ-----PLAGLLADRFGRRPVLLLGLLLFALG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 100 TLLIALVPGYQTIglaapalvLLGRLLQGFSAGVELGGVSVYLSEIATPGNKGFYTSWQSASQQVAIVVAALIGYSLnit 179
Cdd:cd06174 75 ALLFAFAPSFWLL--------LLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGIL--- 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 180 lghDAISEWGWRIPFFIGC-----MIIPLIFVLRRSLQETEAFLQRKHRPDTREIFATIAKNWRIItAGTLLVAMTTTTF 254
Cdd:cd06174 144 ---ASSLGFGWRAVFLIAAalallAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLW-LLLLAIFLVNLAY 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 255 YFITVYTPTYGRTVLNLSARDSLIVTMLVGVSNFIWLPIGGAISDRIGRRAVLMGITLLALITtwpVMQWLTAAPDFTRM 334
Cdd:cd06174 220 YSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMAL---GLALLLLAPSLLLL 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 335 TLVLLWFSFFFGMYNGAMVAALTEVMPVYVRTVGFSLaFSLATAIFGGLTPAISTALVKLTGdkSSPGWWLMCAALCGLA 414
Cdd:cd06174 297 LLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGL-LNTFGFLGGAIGPLLAGFLLAATF--GLTGAFLVLAVLLLLA 373
|
....*
gi 322634933 415 ATAML 419
Cdd:cd06174 374 AILLL 378
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
23-336 |
3.64e-13 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 70.88 E-value: 3.64e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 23 GNFLEQFDFFLFGFYATYIAKTFFPAESEFASLMltfavfGSGFLMRPVGAIVLGAYIDRIGRRKGLMVTLAIMGCGTLL 102
Cdd:PRK03893 28 GYLLDGFDFVLITLVLTEVQGEFGLTTVQAASLI------SAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 103 IALVPGYQTIGLAapalvllgRLLQGFSAGVELGGVSVYLSEIATPGNKGFYTSWQSASQQVAIVVAALIgYSLnitlgh 182
Cdd:PRK03893 102 CGFAPGYWTLFIA--------RLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQV-YSL------ 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 183 dAISEWGWRIPFFIGCMIIPLIFVLRRSLQETEAFLQR-KHRPDTREIFATI-AKNWRIITAGTLLVAMTTTTFYFITVY 260
Cdd:PRK03893 167 -VVPVWGWRALFFIGILPIIFALWLRKNLPEAEDWKEKhAGKAPVRTMVDILyRGEHRIINILLTLAAAAALWFCFAGNL 245
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 322634933 261 TPTYGRTVLNLSARdSLIVTMLVGVSNFIWlPIGgaisdrigrrAVLMGITLLALITTWPVMQWLtaaPDFTRMTL 336
Cdd:PRK03893 246 QNAAIVAVLGLLCA-AIFISFMVQSSGKRW-PTG----------VMLMVVVLFAFLYSWPIQALL---PTYLKTDL 306
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
25-381 |
4.56e-13 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 70.46 E-value: 4.56e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 25 FLEQFDFFLFGFYATYIAKTFFPAESEFASLMlTFAVFGSGFlmrpvGAIVLGAYIDRIGRRKGLMVTLAIMGCGTLLIA 104
Cdd:TIGR00895 27 LMDGYDLAAMGFAAPAISAEWGLDPVQLGFLF-SAGLIGMAF-----GALFFGPLADRIGRRRVLLWSILLFSVFTLLCA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 105 LVPGYqtiglaaPALVLLgRLLQGFSAGVELGGVSVYLSEIATPGNKGFYTSWQSASQQVAIVVAALIGYSLnitlghda 184
Cdd:TIGR00895 101 LATNV-------TQLLIL-RFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWL-------- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 185 ISEWGWRIPFFIGCmIIPLIF--VLRRSLQETEAFLQRKHRPDTREIFATIA------------------KNWRIITAGT 244
Cdd:TIGR00895 165 IPVFGWRSLFYVGG-IAPLLLllLLMRFLPESIDFLVSKRPETVRRIVNAIApqmqaeaqsalpeqkstqGTKRSVFKAL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 245 -------------LLVAMTTTTFYFITVYTPTYGRTvLNLSARDSLIVTMLVGVSNFIWLPIGGAISDRIGRRaVLMGIT 311
Cdd:TIGR00895 244 fqgktaritvllwLLYFMLLVGVYFLTNWLPKLMVE-LGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPR-VTALLL 321
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 322634933 312 LLALITTWPVMQWLTaapDFTRMTLVLLWFSFFFGMYNGAMVAALTEVMPVYVRTVGFSLAFSL--ATAIFG 381
Cdd:TIGR00895 322 LLGAVFAVLVGSTLF---SPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIgrLGAIIG 390
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
70-414 |
5.23e-13 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 70.30 E-value: 5.23e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 70 PVGAIVLGAYIDRIGRRKGLMVTLAIMGCGTLLIALVPGYqtiglaapALVLLGRLLQGFSAGVELGGVSVYLSEIATPG 149
Cdd:cd17358 55 LIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDV--------WMLYLGRFLAGFGGGAASVVVPVYIAEIAPKN 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 150 NKGFYTSWQSASQQVAIVVAALIGYSLNitlghdaisewgWRIPFFIGCmIIPLIFVLRRS-LQETEAFLQRKHRPDT-- 226
Cdd:cd17358 127 VRGALGSLNQLLVNIGILLGYVLGSFLP------------WRTLALIGA-IPPVVFLILLFfIPESPRWLAKKGREEEae 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 227 ------REIFATIAKNWRIITAGTLLVAMTTTTFYFITVYTPTYGRT------------------VLNLSAR-------- 274
Cdd:cd17358 194 kslqflRGKDADISKEAAEIQEELAELEKEAKESSFSDLFQRKYLKPlviglglmlfqqlsginaVIFYASSifdeagsg 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 275 -DSLIVTMLVGVSNFIWLPIGGAISDRIGRR------AVLMGITLLAL---ITTWPVMQWLTAAPDFTRMTLVLLWFSFF 344
Cdd:cd17358 274 lDPNTATIIIGVVQVVGTLVATLLVDRLGRRplllvsAIGMGIGLLALglyFYLQEHGALLSSVSWLPLVGLVIYIISFS 353
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 345 FGMYNGAMVaALTEVMPVYVRtvgfSLAFSLATAIFGGLTPAISTALVKLTGDKSSPGWWLMCAALCGLA 414
Cdd:cd17358 354 IGLGPLPWV-IMSEIFPAKIK----GLAGSLVTLVNWLFAFIVTKTFPFLTLAWGASGTFWIFAGICGLA 418
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
71-372 |
1.76e-12 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 68.53 E-value: 1.76e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 71 VGAIVLGAYIDRIGRRKGLMVTLAIMGCGTLLIALVPGYqtiglaapALVLLGRLLQGFSAGVELGGVSVYLSEIATPGN 150
Cdd:cd17362 54 LGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSY--------PVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHI 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 151 KGFYTSWQSAsqqvAIVVAALIGYSLNITLGHDAiseWGWRIPFFIGCMIIPLIFVLRRSLQETeaflqrkhrPDTReif 230
Cdd:cd17362 126 RGLLVSLKEL----FIVLGILLGYVSGYAFADVV---GGWRYMYGLAAPPALLLGIGMWFLPPS---------PRWQ--- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 231 atiAKNWRIITAGTLLVAMTTTTFY-FITVYTPTYGRTVLNLSARDSLIVTMLVGVSNFIWLPIGGAISDRIGRRAVLMG 309
Cdd:cd17362 187 ---GNYRKPLIIGLGLVLFQQITGQpSVLYYAATIFKSAGFSAASDATLVSVGLGVFKLLMTIVAVLLVDKLGRRPLLLG 263
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 322634933 310 IT---LLALITTWPVMQWLTAAPDFTRMTLV---LLWFSFF---FGMYNGAMVAaltEVMPVYVRTVGFSLA 372
Cdd:cd17362 264 GVsgmVVSLFLLAAYNLFVQMGPAGLAWLSLvalLLYVGAYqisFGPISWLMVS---EIFPLRVRGRAIALA 332
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
71-391 |
2.29e-12 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 67.98 E-value: 2.29e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 71 VGAIVLGAYIDRIGRRKGLMVTLAIMGCGTLLIALVPGYQTIglaapalvLLGRLLQGFSAGVELGGVSVYLSEIATPGN 150
Cdd:cd17359 51 IGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIF--------IIARIIGGLAVGGASALVPMYIAEVAPAEI 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 151 KGFYTSwqsaSQQVAIVVAALIGYSLNITLGHDAISEW----GWRIPFFIGCMIIPLIFVLRRSLQETEAFLQRKHRPdt 226
Cdd:cd17359 123 RGRLVS----LNQLMIVFGQLLAYIVNYLIANAGGADWlgaeGWRWMLGLEAIPAILFLLGMLFIPESPRWLVSKGKP-- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 227 reifatiaknwrIITAGTLLVAM-----TTTTFYFITVYTPTYGrtvlnLSARDSLIVTMLVGVSNFIWLPIGGAISDRI 301
Cdd:cd17359 197 ------------ILIIGIGLAIFqqfvgINVIFYYGPEIFQNAG-----FSENAALLQTIGIGVVNVIFTIIAILLVDKV 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 302 GRRAVLMG-----ITLLALITTWPVMQWLTAAPDFTRMTLVLLwFSFFFGMYNGAMV-AALTEVMPVYVRTVGFSLAFS- 374
Cdd:cd17359 260 GRKPLLLIgsigmAISLLLIGTAFYFAPGSQASGIVALVLILL-FVAFFAMSWGPVTwVLLSEIFPNRIRGLAMGIAVFf 338
|
330
....*....|....*....
gi 322634933 375 --LATAIFGGLTPAISTAL 391
Cdd:cd17359 339 lwIANFLVSLTFPILLAAF 357
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
41-422 |
1.10e-11 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 66.06 E-value: 1.10e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 41 IAKTFFPAESEFASLMLTFAvfgsgFLMRPVGAIVLGAYIDRIGRRKGLMVTLAIMGCGTLLIALVPGYQTIglaapalv 120
Cdd:cd17473 25 IAQHFVPNSELLVPLLLTLP-----ALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYAL-------- 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 121 LLGRLLQGFSAGVELGGVSVYLSEIATPGNKGFYTSWQSASQQVAIVVAALIGyslnitlghDAISEWGWRIPFFIGCMI 200
Cdd:cd17473 92 LASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLG---------GALAEIGWRAPFLVYLLA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 201 IPLIFVLRRSLQETEaflQRKHRPDTREIFATIAKNWRIITAGTLLVAMTTTTFYFITVYTPTYGRTVLNLSARDSLIVT 280
Cdd:cd17473 163 LPVLILVLLFLPEPA---RKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLAL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 281 MLVGVSNFIWLPIGGAISDRIGRRAVLMGITLLALITtwpvMQWLTAAPDFTRMTLVLLWFSFFFGMYNGAMVAALTEVM 360
Cdd:cd17473 240 AIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALG----FLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLV 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 322634933 361 PVYVRTVGFSLafsLATAIFGG--LTPAISTALVKLTGDKSSPgwWLMCAALCGLAATAMLFVR 422
Cdd:cd17473 316 PPELRGRAMGI---VTSAFFLGqfLSPLVLGPLVNLTGGLSGA--FLILGVLALVLAIVLLLLR 374
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
61-375 |
8.37e-11 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 63.44 E-value: 8.37e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 61 VFGSGFLMRPVGAIVLGAYIDRIGRRKGLMVTLAIMGCGTLLIALVPgyqtiglAAPALVLLgRLLQGFSAGVelggVSV 140
Cdd:cd17391 41 AFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVT-------NVWQLLIL-RLLQGVFSGY----VPN 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 141 YLSEIATPGNKGfYTSWQSASQQVAIVVAALIGyslnITLGHDAISEWGWRIPFFIGCMIIPLIFVLrrslqeTEAFLQR 220
Cdd:cd17391 109 ATALIASQTPKE-KSGWALGTLSTGVVAGTLIG----PLLGGFLADLFGIRNVFFITGGLLFLAFLL------TLFFVKE 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 221 KHRPDTREIFATIAKNWRIITAGTLLVAMTTTTFY----------FITVYTPTYGRTVLNLSARDSLIVTMlVGVSNFIW 290
Cdd:cd17391 178 DFKPVEKKKMVSTKEVWNSVPNPSLLISLFVTTFIiqlanqsiepILTLYIRQLMGDASNLAFISGLVFSA-TGVSSLLS 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 291 LPIGGAISDRIGRRAVLMGITLLALITTWPvmqwltaaPDFTRMTLVLLWFSFFFGMYNGAMVAALTEVMPVYVRTVGFS 370
Cdd:cd17391 257 APRLGKLGDRIGHHRILLGALLASALLYIP--------QAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAG 328
|
....*
gi 322634933 371 LAFSL 375
Cdd:cd17391 329 RIFGY 333
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
32-373 |
1.16e-10 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 63.13 E-value: 1.16e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 32 FLFGFYATYIAKT---------FFPAESEFASLMLTFAVFGSGFLMRPVGAIVLGAYIDRIGRRKGLMvtlaIMGCGTLL 102
Cdd:TIGR00879 38 LMFGYDTGVIGGAlalpafefkFTSANSDSYSSSLWGLVVSIFLVGGFIGALFAGWLSDRFGRKKSLL----IIALLFVI 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 103 IALVPGYQTIGLAAPALVLlGRLLQGFSAGVELGGVSVYLSEIATPGNKGFYTSWQSASQQVAIVVAALIGY---SLNIT 179
Cdd:TIGR00879 114 GAILMGLAAFALSVEMLIV-GRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVAYGFGSgkvSLNNT 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 180 LGHDAI--SEWGWRIPFFIGCMIIPLIF--------------VLRRSLQETEAFLQRKHRPDTREIFATIAK-------- 235
Cdd:TIGR00879 193 LGWRIPlgLQLIPAGLLFLGLFFLPESPrwlvgkgrveearkSLARLRGTSGEDKELLDELELIDIKRSIEKrsvqpswg 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 236 ---------NWRIITAGTLLVAMTTTTFYFITVYTPTYGRTVlNLSARDSLIVTMLVGVSNFIWLPIGGAISDRIGRRAV 306
Cdd:TIGR00879 273 slfsstrriRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENA-GVSTDHAFLVSIIVGAVNFAFTFVAIFLVDRFGRRPL 351
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 322634933 307 LMGITLLALIttwpvMQWLTAAPDFTR-----------MTLVLLWFSFFFGMYNGAMVAAL-TEVMPVYVRTVGFSLAF 373
Cdd:TIGR00879 352 LLIGAAGMAI-----CLFVLGILGASFvtgsskssgnvAIVFILLFIAFFAMGWGPVPWVIvSEIFPLSLRPKGISIAV 425
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
71-375 |
3.98e-10 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 61.05 E-value: 3.98e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 71 VGAIVLGAYIDRIGRRKGLMVTLAIMGCGTLLIALVPGYQTIglaapalvLLGRLLQGFSAGVELGGVSVYLSEIATPGN 150
Cdd:cd17315 49 IGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVL--------IVGRFLLGLGVGLASVLVPLYISEIAPAKI 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 151 KGFYtswqSASQQVAIVVAALIGYSLNITLGhdAISEWGWRIPFFIGCMIIPLIFVLRRSLQETeaflqrkhrpdtreif 230
Cdd:cd17315 121 RGAL----GTLNQLMITFGILLAYLLGLALS--LSPPGWWRLMFALAAVPALLQLLLMFFLPES---------------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 231 atiaknwRIITAGTLLVAMTTTT-----FYfitvYTPTYGRTVLNLSArdSLIVTMLVGVSNFIWLPIGGAISDRIGRRA 305
Cdd:cd17315 179 -------RALLVGVGLQLLQQLTginavMY----YAPTIFKSAGGGTA--SILASIIVGVVNLLATLVAIRLVDKVGRRP 245
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 322634933 306 VLM----GITLLALITTWPVMQWLTAAPDFTRMTLVLLWFSFFFGMYNGAMVAALT-EVMPVYVRTVGFSLAFSL 375
Cdd:cd17315 246 LLLigfaGMAASLLLLAIAFLLPALAKAAGWLALLGILLYIAAFAMGAGPVPWLLLsEIFPLRIRGKGMAIATLV 320
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
50-421 |
7.14e-10 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 60.25 E-value: 7.14e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 50 SEFASLMLTFAVFGSGFLMrpvgAIVLGAYIDRIGRRKGLMVTLAIMGCGTLLIALVPGYqtiglaapALVLLGRLLQGF 129
Cdd:COG0738 41 SDAQAGLLLFAFFLGYLLA----SLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSY--------PLLLLALFLLGL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 130 SAGVELGGVSVYLSEIaTPGNKGFYTSWQSASQQVAIVVAALIGYSLnITLGHDAisewGWRIPFFI--GCMIIPLIFVL 207
Cdd:COG0738 109 GLGLLDVAANPYVAAL-GPETAASRLNLLHAFFSLGALLGPLLGGLL-ILLGLSL----SWHLPYLIlaVLLLLLALLFL 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 208 RRSLQETEAflQRKHRPDTREIFATIAKNWRIItAGTLLVAMTTTTFYFITVYTPTYGRTVLNLSARDSLIVTMLVGVSN 287
Cdd:COG0738 183 RSKLPEIEE--EEEEAAGSAASLKSLLKNPRLL-LGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGM 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 288 FIWLPIGGAISDRIGRRAVLMGITLLALITTWPVMqwltaapdFTRMTLVLLWFSFFFGMYNGAMV-AALTEVMPVYVRT 366
Cdd:COG0738 260 TIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLAL--------LAPGPWLALIGLALVGLGLSLMFpTIFSLALDGLGKR 331
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 322634933 367 VGFSLAFSLATAIFGGltpAISTALVKLTGDKSSPGWWLMCAALCGLAATAMLFV 421
Cdd:COG0738 332 TAAAVSAVLIMGIVGG---AIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALA 383
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
56-423 |
1.71e-09 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 59.11 E-value: 1.71e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 56 MLTFAVFgsgflmrpvgAIVLGAYIDRIGRRKGLMVTLAIMGCGTLLIALVPGyqtiglaaPALVLLGRLLQGFSAGVEL 135
Cdd:cd17321 41 LLAFAAL----------LLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPS--------LAFLIAARALQGIGAAAIM 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 136 GGVSVYLSEIATPGNKGFYTSWQSASQQVAIVVAALIGYSLnitlghdaISEWGWRIPFFIGCMIIPLIFVLRRSlqete 215
Cdd:cd17321 103 PASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLL--------LELFGWRWIFLINVPIGLVALLLART----- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 216 aflqrkhrpdtreifatiaknwriITAGTLLVAMTTTTFYFITVYTPTYGRTVLNLSARDSLIVTMLVGVSNFIWLPIGG 295
Cdd:cd17321 170 ------------------------FSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAG 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 296 AISDRIG-RRAVLMGITLLALITTWpvMQWLTAAPDFTRMTLVLLWFSFFFGMYNGAMVAALTEVMPV-----------Y 363
Cdd:cd17321 226 RLADRFGpRLVLVAGLLLTAVGLLL--LALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKekagaasgilnT 303
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 322634933 364 VRTVGFSLAFSLATAIFGGLTPAISTALVKLTGDKSSPGWW-------LMCAALCGLAATAMLFVRL 423
Cdd:cd17321 304 ARQLGGALGVALLGALLTAGLSANLGDSGVAALLSAAAAAFaagfhlaFLVAAALALLAALLALLLP 370
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
71-420 |
5.26e-09 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 57.65 E-value: 5.26e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 71 VGAIVLGAYIDRIGRRKGLMVTLAIMGCGTLLIALVPGYQtiglaapALVLLGRLLQGFSAGVELGGVSVYLSEIATPGN 150
Cdd:cd17356 60 FGALISSFLSDRIGRKKSIQIGCVIYIIGAIIQVAAIGKW-------YQLIVGRIIAGLGVGFASVLVPVYQSEVAPKHI 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 151 KGFYTSWQSASQQVAIVVAALIGYSLNITLGHDAisewgWRIPFFIGCMIIPLIFVLRRSLQETEAFLQRkhrpdtreif 230
Cdd:cd17356 133 RGTLVSLYQLAITIGILVAYCINYGTHKLDGSAQ-----WRIPLGLQIVWGLLLLIGMFFLPESPRWLYR---------- 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 231 atiaknwriITAGTLLVAMTTTT---FYFItvytptYGRTVLN---LSARDSLIVTMLVGVSNFIWLPIGGAISDRIGRR 304
Cdd:cd17356 198 ---------TILGIMLQLFQQLTginYFFY------YGTTIFQstgLTGSSPLLTSIILYIVNFVSTIPGLFFVDKFGRR 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 305 AVLMG--------ITLLALITTWPVMQWLTAAPDFTRMTLVLLWFS----FFFGMYNGAMVAALT-EVMPVYVRTVGFSL 371
Cdd:cd17356 263 TCLLIgaagmsicLFIYAAVGVRYLIPNPQSGTSNKSAGNGMIVFIclfiFSFATTWGPIAWVYVaEVFPLRVRSKGMAL 342
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 322634933 372 AFS---LATAIFGGLTPAIStalvkltgDKSSPGWWLMCAALCGLAATAMLF 420
Cdd:cd17356 343 ATAfnwLWNFLISFFTPFII--------GSIGFKYYYIFAGCNLLAFIVVFF 386
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
71-421 |
5.69e-09 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 57.80 E-value: 5.69e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 71 VGAIVLGAYIDRIGRRKGLMVTLAIMGCGTLLIALVPGYqtiglaapALVLLGRLLQGFSAGVELGGVSVYLSEIATPGN 150
Cdd:cd17437 47 VGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNY--------PVLMVGRFVAGIGVGFALMIAPVYTAEVAPASS 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 151 KGFYTSWqsasQQVAIVVAALIGYSLNITLGhDAISEWGWRIPFFIGCmiIPLIFVLRRSLQETEAflqRKHRPDTREIf 230
Cdd:cd17437 119 RGFLTSF----PEIFINIGILLGYVSNYAFS-GLPLHVGWRLMLGVGA--VPSLFLAIGVLAMPES---PRWTPAVRRM- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 231 atiaknwrIITAGTLLVAMTTTTFYFITVYTPTYGRTVLNLSARDSLIVTMLVGVSNFIWLPIGGAISDRIGRRAVL--- 307
Cdd:cd17437 188 --------LIAALGIHFFQQASGIDAVVLYSPRIFKKAGIKSKDKLLLATVAVGVTKTLFILVATFLLDKVGRRPLLlts 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 308 ---MGITLLALITTWPVMQWLTAAPDFTRMTLVLLWFSF--FFGMYNGAMVAALT-EVMPVYVRtvgfSLAFSLATAIFG 381
Cdd:cd17437 260 tggMTLSLTALATSLTFIDRNGGGLTWALVLAITAVCSFvaFFSIGAGPITWVYSsEIFPLRLR----AQGASLGVVVNR 335
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 322634933 382 GLTPAISTALVKLTGDKSSPGWWLMCAalcGLAATAMLFV 421
Cdd:cd17437 336 LMSGTVSMTFLSMSKAITTGGTFFLFA---GVAAAAWVFF 372
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
80-394 |
1.23e-08 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 56.43 E-value: 1.23e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 80 IDRIGRRKGLMVTLAIMGCGTLLIALVPGYQTIglaapalvLLGRLLQGFSAGVELGGVSVYLSEIATPGNKGFYTSWqs 159
Cdd:cd17503 55 ADRFGTRRLFLTALALFTLGSLLCGLAPNLASL--------IIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGL-- 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 160 asqqvaIVVAALIGYSLNITLGHDAISEWGWRIPFFIGCMIIPLIFVLrrslqetEAFLQRKhrpdtreIFATiaknwRI 239
Cdd:cd17503 125 ------VGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLL-------APLLDLR-------LFKD-----RN 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 240 ITAGTLLVAMTTTTFYFITVYTPTYGRTVLNLSARDSLIVTMLVGVSNFIWLPIGGAISDRIGRRAVLMGITLLALITTW 319
Cdd:cd17503 180 FTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTL 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 320 PvMQWLTAAPDFTRMTLVLLWFSFFFGMYNGAMVAALTEVMPV-----------YVRTVGFSLAFSLATAIFGGLTPAIS 388
Cdd:cd17503 260 L-LAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPeqigdatalfnTIRQLGGSIGTALLATLLTNRTQFHH 338
|
....*.
gi 322634933 389 TALVKL 394
Cdd:cd17503 339 SRLSEL 344
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
61-425 |
1.36e-08 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 56.44 E-value: 1.36e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 61 VFGSGFLMRPVGAIVLGAYIDRIGRRKGLMVTLAIMGCGTLLIALVPGYQTIGLAapalvllgRLLQGFSAGVELGGVSV 140
Cdd:cd17365 39 VGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALL--------RFLTGLGLGAAMPNAIT 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 141 YLSEIATPGNKGFYTSWQSASQQVAIVVAALIGYSLnitlghdaISEWGWRIPFFIGcMIIPLIFVlrrslqeteaflqr 220
Cdd:cd17365 111 LVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAAL--------IPAFGWRSVFLLG-GVPPLILL-------------- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 221 khrpdtreifatiaknwrIITAGTLLVA----MTTTTFYFITVYTPTYGRTVlNLSARDSLIVTMLVGVSNFIWLPIGGA 296
Cdd:cd17365 168 ------------------PLLRGTLLLWvtffMGLLLVYLLNSWLPKLMVEA-GYSLSQALTITLLLNIGGVIGSLLLGW 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 297 ISDRIGRRAVLMGITLLALITTwpVMQWLTAAPDFTRMTLVLLWFSFFFGMYNGaMVAALTEVMPVYVRTVGfsLAFSLA 376
Cdd:cd17365 229 LADRFGPKRVLALFFALGAVSL--ALLGVSPASLVLLYVLVFLAGACVNGAQVG-LYALAARFYPTEVRATG--VGWALG 303
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 322634933 377 TAIFGGLT-PAISTALVKLTGdkSSPGWWLMCAALCGLAATAMLFVRLSR 425
Cdd:cd17365 304 VGRLGAILgPLLGGLLLAAGL--GPESVFLALAIPAALGALAVLLLRLRR 351
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
71-419 |
1.82e-08 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 56.09 E-value: 1.82e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 71 VGAIVLGAYIDRIGRRKGLMVTLAIMGCGTLLIALVPGYqtiglaapALVLLGRLLQGFSAGVELGGVSVYLSEIATPGN 150
Cdd:cd17475 46 VSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSY--------PVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRE 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 151 KGFYTSWQSASQQVAIVVAALIGYSLnitlghdaISEWGWRIPFFIGCMIIPLIFVLR-RSLQETEAFLQRKHRPDTRei 229
Cdd:cd17475 118 RGLAMGIRQTGVPLGGALAAALLPPL--------ALHYGWRAAFVVAGLVSILAAVLFwLFYREPPAASAATESASTL-- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 230 FATIAKN------WRIITAGTLLVAMTtttfYFITVYTPTYGRTVLNLSARDS---LIVTMLVGVSNFIWLpigGAISDR 300
Cdd:cd17475 188 LRSLKEVlrnrdvWLIAIAGALLVAPQ----FALLTFLLLFLHDHLGLSVVAAgalLAVAQLGGALGRIGL---GRVSDR 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 301 I--GRRAVLMGITLLALITTWPVMQWLTAAPDFTRMTLVLLWFSFFFGMYNGAMVAALTEVMPVYVrtVGFSLAFSLATA 378
Cdd:cd17475 261 VfgGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQ--AGTALGLANTIN 338
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 322634933 379 IFG-GLTPAISTALVKLTGDKSSPgwWLMCAALCGLAATAML 419
Cdd:cd17475 339 FIGiAIGPPLFGLLVDATHSYAPA--WLALALLLVLAALLLL 378
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
71-319 |
3.38e-08 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 54.97 E-value: 3.38e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 71 VGAIVLGAYIDRIGRRKGLMVTLAIMGCGTLLIALVPGyqtiglaaPALVLLGRLLQGFSAGVELGGVSVYLSEIATPGN 150
Cdd:cd17360 50 VGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPN--------KEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRI 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 151 KGFYTSWQSasqqVAIVVAALIGYSLNITLGHDAIsewGWRIPFFIGCMIIPLIFVLRRSLQETeaflqrKHRPDTREif 230
Cdd:cd17360 122 RGRLVTINV----LFITGGQFVAYVINGAFSYLPG---GWRWMLGLAAVPAVLQFIGLLFLPES------PRWPSTRR-- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 231 atiaknwRIITAGTLLVAMTTTTFYFITVYTPTYGRTVLNLSARDSLIVTMLVGVSNFIWLPIGGAISDRIGRRAVLMG- 309
Cdd:cd17360 187 -------ALIVGCGLQAFQQFSGINTVMYYSATILQMAGFKDNQNAIWLSLIVAGTNFIFTIVGMYLIDKFGRRKLLLIs 259
|
250
....*....|....
gi 322634933 310 ----ITLLALITTW 319
Cdd:cd17360 260 lfgvIVALVVLAVW 273
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
61-365 |
3.57e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 54.88 E-value: 3.57e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 61 VFGSGFLMRPVGAIVLGAYIDRIGRRKGLMVTLAIMGCGTLLIALVPGYQTIglaapalvLLGRLLQGFSAGVELGGVSV 140
Cdd:cd17474 39 LITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALL--------LAGRALQGIGAAGLGPLALT 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 141 YLSEIATPGNKGFYTSWQSASQQVAIVVAALIGyslnitlghDAISEWGWRIPFFIGCMIIPLIFVlrrslqeTEAFLQR 220
Cdd:cd17474 111 LIGDLFEGGERAKAMGLYEAALGLGIAVGPLLG---------GLLAAISWRYPFFLLAALIPVAFL-------AILFLLP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 221 KHRPDTREIFATIAKNWRIITAGTLLVAMTTTTFYFITVYTP--TYGRTVLNLSARDSLIVTMLVGVSNFIWLPIGGAIS 298
Cdd:cd17474 175 EPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAflTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFV 254
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 322634933 299 DRIGRRAVLMGITLLALITTWPV-MQWLTAAPDFTRMTLVLLWFSFFFGMYNGAMVAALTEVMPVYVR 365
Cdd:cd17474 255 GRLLKKRFGARRILVIGLLLYALsLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEER 322
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
56-420 |
6.13e-08 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 54.10 E-value: 6.13e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 56 MLTFAVFGSGFLMRPVgaivLGAYIDRIGRRKGLMVTLAIMGCGTLLIALVPGYQTIGLAApalvllgrLLQGFSAGV-- 133
Cdd:cd17478 35 LLVSVFSITSSLLQPL----FGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLV--------ALAGIGSAAfh 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 134 ELGGVSVYLseiATPGNKGFYTSWQSASQQVAIVVAALIGYSLNITLGHDAiseWGWRIPFFIGCMIIPLIFVLRRSLQE 213
Cdd:cd17478 103 PEGARLASQ---AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLG---LLILLIIPGLAVALLLLRLRPLKKPE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 214 teaflqRKHRPDTREIFATIAKNWRIITAGTLLVAMTTTTFYFITVYTPTY--GRTVLNLSARDSLIVTMLVGVsnfIWL 291
Cdd:cd17478 177 ------AKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYlvQRGYSLVFAGLLLSLFLFAGA---IGT 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 292 PIGGAISDRIGRRAVLMGITLLALittwPVMQWLTAAPDFTRMTLVLLwFSFFFGMYNGAMVAALTEVMPVYVRTV-GFS 370
Cdd:cd17478 248 LIGGPLSDRFGRRRVIIASLLLAA----PFLLLFLLTPGIWSYILLVL-AGFLLFASFPVTVVLAQELLPGNVGLAsGLM 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 322634933 371 LAFSLATAifggltpAISTALVKLTGDKSSPGWWLMCAALCGLAATAMLF 420
Cdd:cd17478 323 MGLSFGLG-------GIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
23-346 |
7.24e-08 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 54.21 E-value: 7.24e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 23 GNFLEQFDFFLFGFYATYIAKTFFPAESEFASLMLTfAVFGSGFLMRPVGAIVLGAYIDRIGRRKGLMVTLAIMGCGTLL 102
Cdd:cd17364 7 GFFTDAYDLFSISLVTKILGRLYYGGKGSLPSGVSG-LVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTIL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 103 IALVPGYqtIGLAAPALVLLGRLLQGFSAGVELGGVSVYLSEIATPGNKGFYTSWQSASQQVAIVVAALIGYSLNITLGH 182
Cdd:cd17364 86 SALSPGS--TPLGVMGWLIFFRFLLGIGIGGDYPLSATIMSEYANKKRRGALIAAVFAMQGFGILAGAIVTLILSAIFEH 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 183 DAIS------EWGWRIPFFIGCMIIPLIFVLRRSLqeteaflqrkhrpdtreifatiaknwrIITAGTLLvaMTTTTFYF 256
Cdd:cd17364 164 PLPAgtyhhaDLVWRIVLGLGAIPALSVLYFRKHL---------------------------LGTAGTWF--LLDIAFYG 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 257 ITVYTPT--------YGRTVLNLSARDSLIVTMLVGVSNFIWLPIGGAISDRIGRRAVLM----GITLLALITTWPVMQW 324
Cdd:cd17364 215 QNLFQSTiisaigfsKTMNAYQELFNIAVGQLIIALAGTVPGYWFTVFLIDRIGRKKIQMmgffGMTIFLLILAGPYDHW 294
|
330 340
....*....|....*....|..
gi 322634933 325 LTAAPDFtrmtLVLLWFSFFFG 346
Cdd:cd17364 295 KISTIGF----FVLYGLTFFFS 312
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
60-418 |
2.21e-07 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 52.56 E-value: 2.21e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 60 AVFGSGFLmrpVGAIVLGAYIDRIGRRKGLMVTLAIMGCGTLLIALVPGyqtiglaaPALVLLGRLLQGFSAGVELGGVS 139
Cdd:cd17477 38 SAYYLGIL---LGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDS--------PWVWFLLRFVMGIGLAGLFVVSE 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 140 VYLSEIATPGNKGFYTSWQSASQQVAIVVAALIGyslnitlghDAISEWGWRIPFFIG-CMIIPLIFVLRRSLQETEafl 218
Cdd:cd17477 107 SWLNALATNENRGRVLGLYSTVLGLGFALGPLLL---------ALVGTAGALPFLIAAvLLLLALVPLLLTRRAAPE--- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 219 qrKHRPDTREIFATIAKNWrIITAGTLLVAMTTTTFY-FITVYTptygrTVLNLSARDSLIVTMLVGVSNFIWLPIGGAI 297
Cdd:cd17477 175 --IEEAESISLRRLLRIAP-LALLGAFVAGFLEGAFYsLLPLYG-----LRLGLSVAQAALLLAAFVLGGLLLQWPLGWL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 298 SDRIGRRAVLMGITLLALITTwpVMQWLTAAPDFTRMTLVLLWFSFFFGMYNGAMVAALTEVMPvyVRTVGFSLAFSLAT 377
Cdd:cd17477 247 ADRFDRRRVLLGCALLGALAA--LLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPG--DELVAANAALLLLY 322
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 322634933 378 AIFGGLTPAISTALVKLTGDKsspGWWLMCAALCGLAATAM 418
Cdd:cd17477 323 GLGSVIGPLLAGALMDAFGPH---GLFLFLAAVALLFLLFL 360
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
36-431 |
5.20e-07 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 51.69 E-value: 5.20e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 36 FYATYIAKTFFPAESEFASLMLTFAVFGSGFLMrPVGAIVLGAYIDRIGRRKGLMVTLAIMGC-GTLLIALVPGyqtiGL 114
Cdd:COG2270 33 VFPPYFTSVAALGDPAAATALWGYALAIAGLLV-ALLAPVLGAIADRSGRKKPFLAFFTLLGVlATAALFFVAP----GG 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 115 AAPALVLLGRLLQGFSAGVELggVSVYLSEIATPGNKGFYTSWQSASQQVAIVVAALIGYSLNITLGHDAISEWGWRIPF 194
Cdd:COG2270 108 LWLGLLLFVLANIGFEGSLVF--YNAFLPDIATPEEIGRVSGLGWALGYLGGVLLLLINLALFLKPEAFGLPDAGEAVRI 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 195 -------FIGCMIIPLIFVLRRSLQETEAFLQRKHRPDTREIFATIAKNWRIITAGTLLVAMT------TTTFYFITVyt 261
Cdd:COG2270 186 sflltalWWLLFALPLFLFLPERPRPGPAPPRGAVRAGFRELRRTLRELRRYRDLLRFLLAYFfyrdgvQTVIAFAGI-- 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 262 ptYGRTVLNLSARDSLIVTMLVGVSNFIWLPIGGAISDRIG-RRAVLMGITLLALITTWPVmqwltaapdFTRMTLVLLW 340
Cdd:COG2270 264 --YAAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGpKRVILVSLVIWIVVCLAAY---------FLTTALAFWI 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 341 FSFFFGMYNGAMVAA----LTEVMPVYVRTVGFSL-AFSL-ATAIFGgltPAISTALVKLTGdkSSPGWWLMCAALCGLA 414
Cdd:COG2270 333 LGLLIGLVMGGIQALsrslLARLIPPGREAEFFGLyALSGkAASFLG---PLLFGLVTQLTG--SQRLGILSLIVFFVIG 407
|
410
....*....|....*..
gi 322634933 415 ATAMLFVRLSRGYIAAE 431
Cdd:COG2270 408 LVLLLRVKVPRGRAAAG 424
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
71-190 |
7.75e-07 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 51.52 E-value: 7.75e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 71 VGAIVLGAYIDRIGRRKGLMVTLAIMGCGTLLIALVPGYQTIglaapalvLLGRLLQGFSAGVELGGVSVYLSEIATPGN 150
Cdd:TIGR01299 217 VGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFF--------LFCRLLSGFGIGGAIPIVFSYFAEFLAQEK 288
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 322634933 151 KGFYTSWQSASQQVAIVVAALIGYSLnitlghdaISEWGW 190
Cdd:TIGR01299 289 RGEHLSWLCMFWMIGGIYAAAMAWAI--------IPHYGW 320
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
50-422 |
1.20e-06 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 50.25 E-value: 1.20e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 50 SEFASLMLTFAVFGSGFLMRPVGAIVLGAYIDRIGRRKGLMVTLAIMGCGTLLIALVPGYQTiglaapalVLLGRLLQGF 129
Cdd:cd17502 24 AEFGGLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTM--------LIVGRAIQGI 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 130 SAGVELGGVSVYLSEIATPGNKGFYTSWQSASQQVAIVVAALIGYSLnitlghdaISEWGWRIPFFIGCMIIPLIFVLRR 209
Cdd:cd17502 96 GGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAF--------TDHLSWRWCFYINLPIGGLALALLR 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 210 SlqeteaflqrkhrpdtreifatiaknwriITAGTLLVAMTTTTFYFITVYTPTYGRTVLNLSARDSLIVTMLVGVSNFI 289
Cdd:cd17502 168 T-----------------------------ILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVI 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 290 WLPIGGAISDRIGRRAVLMGI-TLLALITTWpVMQWLTAAPDFTRMTLVLLWFSFFFGMYNGAMVAALTEVMPVYVRTVG 368
Cdd:cd17502 219 GSIISGALISKTGRYKPLIVIgTILMSVGAG-LLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVA 297
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 322634933 369 ---FSLAFSLATAIFGGLTPAistalvkltgdksspgwWLMCAALCGLAATAMLFVR 422
Cdd:cd17502 298 tatNTFFRSLGGTLGVAITDV-----------------FLVALALAALAFLLSLFLP 337
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
57-422 |
1.21e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 50.29 E-value: 1.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 57 LTFAVFGSGFLMRPVGaivlGAYIDRIGRRKGLMVTLAIMGCGTLLIALVPGyqtiglaaPALVLLGRLLQGFSAGVELG 136
Cdd:cd17489 36 VVGLFTLAALLARPFA----GRLLDRFGRKRLLLIGLLIFALATLLYLLATS--------VALLLVLRLIHGIGWGAFTT 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 137 GVSVYLSEIATPGNKGFYTSWQSASQQVAIVVAALIGYSLnitlghdaISEWGWRIPFFIGCMIIPLIFVLRRSLQETEA 216
Cdd:cd17489 104 AAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFL--------YQHLGFAVLFIVAAVLALLALLLVFLVKDPPP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 217 FLQRKHRPDTREIFATIAKNWRIITAGTLLVAMTTTTfyfITVYTPTYGRTvlnLSARDSLIVTMLVGVSNFIWLPIGGA 296
Cdd:cd17489 176 VAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGA---ISTFLPLYAAE---RGISNAGLFFTVYAIALLLSRPFSGK 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 297 ISDRIGRRAVLM-GITLLALITtwpVMQWLTAAPdftrmtLVLLWFSFFFGMYNGAMVAALTEVM----PVYVRTVGFSl 371
Cdd:cd17489 250 LSDRKGPKTVIIpGLLLLALGL---LLLSFAGSP------WMLLLAAVLYGLGFGLLFPALQALAvdlvPPHRRGAANG- 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 322634933 372 AFSLATAIFGGLTPAISTALVKLTGdksSPGWWLMCAALCGLAATAMLFVR 422
Cdd:cd17489 320 TFFIFFDLGIGLGGLLLGLVAELFG---YRAMFLLAAVVVLLALVLYIFLL 367
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
61-337 |
4.34e-06 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 48.81 E-value: 4.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 61 VFGSGFLMRPVGAIVLGAYIDRIGRRKGLMVTLAIMGCGTLLIALVPGYQTIglaapalvLLGRLLQGFSAGVELGGVSV 140
Cdd:PRK11551 55 AFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSL--------LVARLLTGVGLGGALPNLIA 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 141 YLSEIATPGNKGFYTSWQSASQQVAIVVAALIGyslnITLGHDAisewGWRIPFFIGCmIIPLIFV--LRRSLQETEAFL 218
Cdd:PRK11551 127 LTSEAVGPRLRGTAVSLMYCGVPFGGALASVIG----VLAAGDA----AWRHIFYVGG-VGPLLLVplLMRWLPESRAFA 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 219 QRKHRPDTREIFA-TIAKNWRIITAGTLLVA--MTTTTFYFITVYTP--TYGRtvlNLSARDSLIVTMLVGVSNFIWLPI 293
Cdd:PRK11551 198 QAAGAGKQRAPVLrALFGEGRATATLLLWISyfFTLIVLYFLLNWLPslLVGQ---GLSRSQAGLVQIAFNIGGALGSLL 274
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 322634933 294 GGAISDRIGRRAVLMGI---TLLALITtwpvmqwLTAAPDFTRMTLV 337
Cdd:PRK11551 275 IGALMDRLRPRRVVLLIyagILASLAA-------LAAAPSFAGMLLA 314
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
71-190 |
5.70e-06 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 48.38 E-value: 5.70e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 71 VGAIVLGAYIDRIGRRKGLMVTLAIMGCGTLLIALVPGYqtiglaapALVLLGRLLQGFSAGVELGGVSVYLSEIATPGN 150
Cdd:cd17438 49 AGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGY--------GAFLFCRLISGFGIGGSLPIVFAYFSEFLAREK 120
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 322634933 151 KGFYTSWQSASQQVAIVVAALIGYSLnitlghdaISEWGW 190
Cdd:cd17438 121 RGEHLSWLCMFWMIGGLYASAMAWSI--------IPHYGW 152
|
|
| MFS_GLUT10_Class3 |
cd17436 |
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
60-384 |
6.76e-06 |
|
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340994 [Multi-domain] Cd Length: 376 Bit Score: 47.87 E-value: 6.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 60 AVFGSGFLMRPVGAIVLGAYIDRIGRRKGLMVTLAIMGCGTLLIALVPGYqtiglaapALVLLGRLLQGFSAGVELGGVS 139
Cdd:cd17436 40 ALVSALLIGALLASLIGGFLIDRHGRRTSILGSNLVLLAGSLILTLAGSF--------FWLVIGRAVVGFAISVSSMACC 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 140 VYLSEIATPGNKGFYTSWQSASQQVAIVVAALIGYSLNITLghdaiseWGWRIPFfiGCMIIPLIFvlrrslqeteAFLQ 219
Cdd:cd17436 112 IYVSEMVTPHQRGLLVSLYEAGITVGILISYALNYFFSNVL-------TGWRYMF--GLAIIPAAI----------QFAS 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 220 RKHRPDTREIFATIAKNWRIITAGTLLVAMTTTTFY-FITVYTPTYGRTVLNLSARDSLIVTMLVGVSNFIWLPIGGAIS 298
Cdd:cd17436 173 ILLLPKKPEVLNIKDNMRRRTLVGLGLVLFQQFTGQpNVLCYASTIFRSVGFQSNSSAVLASVGLGVVKVIATLLAMLFA 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 299 DRIGRRAVLMGITLLALITTWPVMQWLTaapdFTRMTLVLLWFSFFFGMYNGAMvaaLTEVMPVYVRTVGFSL--AFSLA 376
Cdd:cd17436 253 DRAGRRSLLIAGCSVMAVSVSGIGLWIT----LLCLMAFVSAFSIGFGPMTWLV---LSEIYPADIRGRAFSFcnSFNWA 325
|
....*...
gi 322634933 377 TAIFGGLT 384
Cdd:cd17436 326 ANLLITLS 333
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
52-422 |
1.53e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.84 E-value: 1.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 52 FASLMLTFAVFGSGFLMRPVGAIVLGAYIDRIGRRKGLMVTLAIMGCGTLLIALVPGYQTIGLAAPALVLlgrLLQGFSA 131
Cdd:cd06173 30 TGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLA---FLLGIAS 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 132 GVELGGVSVYLSEIATPGNKGFYTSWQSASQQVAIVVAALIGYSLnitlghdaISEWGWRIPFFIGCMIIPLIFVLRRSL 211
Cdd:cd06173 107 AFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLL--------VALLGPGGAFAINALSFLLSALLLLFI 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 212 QETEAFLQRKHRPDTREIFA---TIAKNWRIITAGTLLVAMTTTTFYFITVYTPTYGRTVLNLSARDSLIVTMLVGVSNF 288
Cdd:cd06173 179 RRPPPAAPGESSSLLLRDLReglRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGAL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 289 IWLPIGGAISDRIGRRAVLMGITLLALITTWpvmqWLTAAPDFTRMTLVLLWFSFFFGMYNGAMVAALTEVMPVYVRTVG 368
Cdd:cd06173 259 LGALLLGRLSKRRRRGRLLLIGALLLGLALL----VLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRV 334
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 322634933 369 FSLAFSLATAIFggltpAISTALVKLTGDKSSPGWWLMCAALCGLAATAMLFVR 422
Cdd:cd06173 335 FSVYNALNSGAM-----PLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
57-422 |
2.26e-05 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 46.41 E-value: 2.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 57 LTFAVFGSGFLmrpVGAIVLGAYIDRIGRRKGLMVTLAIMGCGTLLIALVPGYQTIglaapalvLLGRLLQGFSAGVELG 136
Cdd:cd17320 38 LTLSAYLLGFA---LGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQL--------LIARFLQGLGAAAGSV 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 137 GVSVYLSEIatpgnkgfYTSWQSASQQVAIVVAALIGYSLNITLGHDAISEWGWRIPF-FIGCMIIPLIFVLRRSLQETE 215
Cdd:cd17320 107 VARAIVRDL--------YSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFvFLALLGLLLLLLVLLFLPETL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 216 AFLQRKHRP-DTREIFATIAKNWRIITAGTLLVAMTTTTFYFITVyTPTYGRTVLNLSARDSLIVTMLVGVSNFIWLPIG 294
Cdd:cd17320 179 PEEKRKPLLsSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAA-APFIYIEQLGLSPAQFGLLFALNAIALILGSLLN 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 295 GAISDRIG-RRAVLMGITLLALITTWPVMQWLTAAPDFTRMTLVLLWFSFFFGMYNGAMVAALTEvmpvyvrtvGFSLAF 373
Cdd:cd17320 258 GRLVRRFGpRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALE---------PFPHVA 328
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 322634933 374 SLATAIFGGLTPAISTALVKLTGDKSSPGWWLMCA--ALCGLAATAMLFVR 422
Cdd:cd17320 329 GTASALLGFLQFLIGALAGALVGLLPNGTALPMGLliLVLGLLALLLLILL 379
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
71-207 |
2.42e-05 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 43.79 E-value: 2.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 71 VGAIVLGAYIDRIGRRKGLMVTLAIMGCGTLLIALVPGYQTIglaapalvLLGRLLQGFSAGVELGGVSVYLSEIATPGN 150
Cdd:TIGR00880 13 IYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVL--------IIARFLQGFGAAFALVAGAALIADIYPPEE 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 322634933 151 KGFYTSWQSASQQVAIVVAALIGYSLnitlghdaISEWGWRIPFFIGCMIIPLIFVL 207
Cdd:TIGR00880 85 RGVALGLMSAGIALGPLLGPPLGGVL--------AQFLGWRAPFLFLAILALAAFIL 133
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
71-422 |
3.76e-05 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 45.63 E-value: 3.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 71 VGAIVLGAYIDRIGRRKGLMVTLAIMGCGTLLIALVPGYqtiglaapALVLLGRLLQGFSAGVELGGVSVYLSEiATPGN 150
Cdd:COG2807 68 LFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSV--------ALLLAGTALIGAGIAVGNVLLPGLIKR-WFPDR 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 151 KGFYTSWQSASQQVAIVVAALIGYSLnitlghdaISEWGWRIPFFIGCMIIPLIFVLRRslqeteAFLQRKHRPDTREIF 230
Cdd:COG2807 139 VGLMTGLYTAAMGLGAALAAGLTVPL--------AAALGWRGALAVWALLALLALLLWL------PLLRRRPAAAAAAPA 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 231 ATIAKN-WRIITAGTLLVAMTTTTFYFITVYT--PTYGRTvLNLSARDSLIVTMLVGVSNFIWLPIGGAISDRIGRRAVL 307
Cdd:COG2807 205 AASLRSlWRSPLAWLLTLFFGLQSLLYYAVVAwlPPILRD-AGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPL 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 308 MGITLLALITTWPVMQWLTAApdftrmtlVLLWFSFFFGMYNGAMVAALTEVMPVYVRTVGFSLAFS----LATAIFGGL 383
Cdd:COG2807 284 LLLLGLLGLAGLLGLLLAPGS--------LPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAALSgmaqSVGYLLAAL 355
|
330 340 350
....*....|....*....|....*....|....*....
gi 322634933 384 TPAISTALVKLTGDkSSPGWWLMCAALCGLAATAMLFVR 422
Cdd:COG2807 356 GPLLVGALHDATGS-WTAALLLLAALAVLMLVAGLLAGR 393
|
|
| MFS_STP |
cd17361 |
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ... |
76-309 |
4.17e-05 |
|
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340919 [Multi-domain] Cd Length: 390 Bit Score: 45.32 E-value: 4.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 76 LGAYIDRIGRRKGLMvtlaiMGCGTLLIALVpgyqTIGLAAP--ALVLLGRLLQGFSAGVELGGVSVYLSEIATPGNKGF 153
Cdd:cd17361 70 LASYVTRKWGRKPSM-----LIGGVLFLVGA----ALNAAAQniAMLIVGRILLGFGVGFGNQAVPLYLSEMAPAKLRGA 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 154 YTSWQSASQQVAIVVAALIGYslnitlGHDAISEWGWRIPffIGCMIIPLIFVLRRSLqeteaFLqrkhrPDTreifati 233
Cdd:cd17361 141 LNIGFQLAITIGILIANLINY------GTSKIKPNGWRLS--LGLAAVPALILLLGSL-----FL-----PET------- 195
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 322634933 234 aKNWRIITAGTLLVAMTTTT-FYFITVYTPTYGRTvLNLSARDSLIVTMLVGVSNFIWLPIGGAISDRIGRRAVLMG 309
Cdd:cd17361 196 -PNSPQLVIAILIPFFQQLTgINVIMFYAPVLFQT-LGFGSDASLISAVITGAVNVVSTLVSIYLVDRFGRRFLLLE 270
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
32-416 |
1.44e-04 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 43.78 E-value: 1.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 32 FLFGFYATYIAKTFFPAESEFAslMLTFAVFGSGFLMRpvgaIVLGAYIDRIGRRKGLMVTLAIMGCGTLLIALVpgyqt 111
Cdd:cd17341 16 FLFAPLGPVIRDDLGLSTSQIG--LLVAIPVLAGALLR----LPYGFLCDRFGGRRVFIASLLLLLIPLLALALA----- 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 112 igLAAPALVLLGRLLQGFSAGVELGGVSvYLSEIATPGNKGFYTSWQSASQQVAIVVAALIGYSLnITLGHDAISEWGWR 191
Cdd:cd17341 85 --VSSYWGLLVLGFLLGFAGANFASGQP-WASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLI-AGAIVFDGGFVGWR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 192 IPFFIGCMIIPLIFVLRRSLQETEAFlQRKHRPDTREIFATIAKNWRIITAGtLLVAMTTTTFYFITVYTPTYGRTVLNL 271
Cdd:cd17341 161 NAFFVPGILLAIAAVLVLLFGDDLPT-GKASALEFLKVQLAVLKNYRTWILS-LLYGVTFGSFVGFSNVLPTYFKTRFGL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 272 SARDSLIVTMLVGVSNFIWLPIGGAISDRIGRRAVLM----GITLLALITTWPVmqwltaaPDFTRMTLVLLWFSFFFGM 347
Cdd:cd17341 239 PLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWwlfiVMTIGAALLSLSL-------PTSGTNLVLFLALFVALGL 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 322634933 348 YNGAMVAALTEVMP-VYVRTVGFSLAFSLAT-AIFGGLTPAISTALVKLTGDKSS-PGWWLMCAALCGLAAT 416
Cdd:cd17341 312 GAGAGNGSVFRMVPfIFRRELGAVTGLVGAIgGLGGFFLPLLFGSSALMTGSGVGaFSLFGVLAVACTLLVW 383
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
71-190 |
1.47e-04 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 44.02 E-value: 1.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 71 VGAIVLGAYIDRIGRRKGLMVTLAIMGCGTLLIALVPGYqtiglaapALVLLGRLLQGFSAGVELGGVSVYLSEIATPGN 150
Cdd:cd17363 49 VGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQGY--------GFFLFCRLLSGIGIGGSIPIVFSYFAEFLAREK 120
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 322634933 151 KGFYTSWQSASQQVAIVVAALIGYSLnitlghdaISEWGW 190
Cdd:cd17363 121 RGEHLSWLCMFWMIGGLYASAMAWAI--------IPHYGW 152
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
71-190 |
1.48e-04 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 43.87 E-value: 1.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 71 VGAIVLGAYIDRIGRRKGLMVTLAIMGCGTLLIALVPGYQTIglaapalvLLGRLLQGFSAGVELGGVSVYLSEIATPGN 150
Cdd:cd17439 49 VGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGTF--------LFCRLLSGVGIGGSIPIVFSYFSEFLAQEK 120
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 322634933 151 KGFYTSWQSASQQVAIVVAALIGYSLnitlghdaISEWGW 190
Cdd:cd17439 121 RGEHLSWLCMFWMIGGIYASAMAWAI--------IPHYGW 152
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
70-317 |
1.55e-04 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 43.79 E-value: 1.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 70 PVGAIvLGAYI-----DRIGRRKGLMVTLAIMGCGTLLIALvpgyqTIGLAAPALVLLGRLLQGFSAGVELGGVSVYLSE 144
Cdd:cd17357 59 FIGGA-IGSFIsaflaNRFGRKNGLLISNALLVVSSLLMFL-----SKSAKSPELLIFGRFLVGIACGLSTGFVPMYLQE 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 145 IATPGNKGFYTSWQSASQQVAIVVAALIGysLNITLGhdaiSEWGWRIPFFIG-----CMIIPLIFV------------- 206
Cdd:cd17357 133 ISPSELRGALGSLTQIGVTLGILLGQVFG--LPSVLG----TETLWPYLLFFPgipalLQLAALPFFpespkflliskgd 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 207 ----------LRRSLQETEAFLQRKHRPDT----------REIFATIAKNWRIITAGTLLVAMTTTTFYFITVYTpTYGR 266
Cdd:cd17357 207 eeeaekslkfLRGIEDDVDQELEEIKKESEqmgdqkqvslMQLLRDPSLRLPLLLVLVVSASQQFSGINAIFFYS-TFIF 285
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 322634933 267 TVLNLSARDSLIVTMLVGVSNFIWLPIGGAISDRIGRRAVLMGITLLALIT 317
Cdd:cd17357 286 ENAGFSPQLAEWANLGIGIVNVLSTIVGPFLIEKVGRRPLLLISLSVCAVA 336
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
74-421 |
2.13e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 43.33 E-value: 2.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 74 IVLGAYIDRIGRRKGLMVTLAIMGCGTLLIALVPGYQTIglaapalvLLGRLLQGFSAGVELGGVSVYLSEIATPGNKGF 153
Cdd:cd17319 56 VPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSL--------YVLRFLLGVAEAGFFPGAIKALAEWFPARERGR 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 154 YTSWQSASQQVAIVVAALIGYSLnitlghdaISEWGWRIPFFI-GCMIIPLIFVLRRSLQETEAFlqrkhrpdtreifat 232
Cdd:cd17319 128 ATGLFNSGAPLGAAIGPPLSGWL--------LLLFGWRWAFIIeGLLGLLLAVLWWFYLRQVWGL--------------- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 233 iaknwriitagTLLVAMTTTTFYFITVYTPTYGRTVLNLSARDSLIVTMLVGVSNFIWLPIGGAISDRI---GRRAVLMG 309
Cdd:cd17319 185 -----------ALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrgARRLVIII 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 310 ITLLALITtwpvmqwLTAAPDFTRMTLVLLWFS---FFFGMYNGAMVAALTEVMPVYVRTVGFSLAFSLAtAIFGGLTPA 386
Cdd:cd17319 254 GLLLAAVG-------LLLAYLTTSPVVAVILLSlagFGIGAASPVFWSLPADLLPGEAAATAGGLINSGG-NLGGFVAPL 325
|
330 340 350
....*....|....*....|....*....|....*
gi 322634933 387 ISTALVKLTGDKSSPgwWLMCAALCGLAATAMLFV 421
Cdd:cd17319 326 LIGYLVDATGSYTAA--FLFLAAVALLAALLVLLL 358
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
71-157 |
3.04e-04 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 42.98 E-value: 3.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 71 VGAIVLGAYIDRIGRRKGLMVTLAIMGCGTLLIALVPGYqtiglaapALVLLGRLLQGFSAGVELGGVSVYLSEIATPGN 150
Cdd:cd17440 49 VGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSSFVQGY--------GLFLFCRLLSGFGIGGAVPTVFSYFAEVLAREK 120
|
....*..
gi 322634933 151 KGFYTSW 157
Cdd:cd17440 121 RGEHLSW 127
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
23-223 |
4.31e-04 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 42.22 E-value: 4.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 23 GNFLEQFDFFLFgFYATYIAKTFFPAESEFASLMLTFAvfgsgFLMRPVGAIVLGAYIDRIGRRKGLMVTLAIMGCGTLL 102
Cdd:PRK12307 26 GYVFDGFDFMLI-FYIMYLIKADLGLTDMEGAFLATAA-----FIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 103 IALVPGYqtiglaapALVLLGRLLQGFSAGVELGGVSVYLSEIATPGNKGFYTSWQSASQQVAIVVAALIGYSLnitlgh 182
Cdd:PRK12307 100 SGLASGV--------IMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGIGNIIAAYFMPSF------ 165
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 322634933 183 daISEWGWRIPFFIGCMIIPLIFVLRRSLQETEAFLQRKHR 223
Cdd:PRK12307 166 --AEAYGWRAAFFVGLLPVLLVIYIRARAPESKEWEEAKLS 204
|
|
| MFS_GLUT6_Class3 |
cd17434 |
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
81-180 |
4.55e-04 |
|
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340992 [Multi-domain] Cd Length: 417 Bit Score: 42.13 E-value: 4.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 81 DRIGRRKGLMVTLAIMGCGTLLIALVPGYQtiglaapaLVLLGRLLQGFSAGVELGGVSVYLSEIATPGNKGFYtswqSA 160
Cdd:cd17434 66 DRLGRKLSIMFSAVPSALGYLLMGSAQGIW--------MLLLGRFLTGFAGGITAASIPVYVSEISHPGVRGAL----GA 133
|
90 100
....*....|....*....|
gi 322634933 161 SQQVAIVVAALIGYSLNITL 180
Cdd:cd17434 134 CPQIMAVFGSLALYALGLLL 153
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
124-354 |
5.77e-04 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 41.85 E-value: 5.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 124 RLLQGFSAGVELGGVSVYLSEIATPGNKGFYTSWQSASQQVAIVVAALIGYSLNITLGHDAISewGWRIPFFI-GCMIIP 202
Cdd:cd17327 101 RFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKILGVGGLA--GWRWLFIIeGLITII 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 203 LIFVL----------RRSLQETEAFLQRKHRPDTRE----------IFATIAKNWRIITAGTLLVAMTTTTfYFITVYTP 262
Cdd:cd17327 179 IGLVIffwlpdnpskAWFLTEEEKELAVERLRANQTgkgdqkfkwkQIKEAFKDPRTWLLFLFFFCSQITN-NGISNFLP 257
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 263 TYGRTvLNLSARDSLIVTMLVGVSNFIWLPIGGAISDRIGRRAVLMGITLLALITTWPVMQWLTAAPdftrmtlVLLWFS 342
Cdd:cd17327 258 LILKS-LGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFACVLALVGSIILLAAPNPP-------GAYFAA 329
|
250
....*....|..
gi 322634933 343 FFFGMYNGAMVA 354
Cdd:cd17327 330 YILGGGSYAGFP 341
|
|
| MFS_GLUT_Class2 |
cd17432 |
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
36-146 |
6.75e-04 |
|
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340990 [Multi-domain] Cd Length: 452 Bit Score: 41.83 E-value: 6.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 36 FY-ATYIAKTFFPAESEFASLM--LTFAVFGSGFLmrpVGAIVLGAYIDRIGRRKGLMV--TLAIMGCGTLLIALVPGyq 110
Cdd:cd17432 30 FYnETWTERYGTPLEESTLTLLwsLTVSIFPLGGL---FGSLLVGPLVIRLGRKGTLLLnnIFAIVAAILMGLSKIAK-- 104
|
90 100 110
....*....|....*....|....*....|....*.
gi 322634933 111 tiglaAPALVLLGRLLQGFSAGVELGGVSVYLSEIA 146
Cdd:cd17432 105 -----SFEMIIVGRFLVGINAGISLNVVPMYLGESA 135
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
57-431 |
7.65e-04 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 41.54 E-value: 7.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 57 LTFAVFGSGFLmrpVGAIVLGAYIDRIGRRKGLMVTLAIMGCGTLLIALVPGYQTIglaapaLVLlgRLLQGFSagveLG 136
Cdd:TIGR00898 131 LTQSCFFVGVL---LGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVF------LVF--RLLVGMG----IG 195
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 137 GVSVylseIATPgnkgFYTSWQSASQQVAIVVAALIGYSLNI---TLGHDAISEWGW-----RIPFFIGCMII------P 202
Cdd:TIGR00898 196 GIWV----QAVV----LNTEFLPKKQRAIVGTLIQVFFSLGLvllPLVAYFIPDWRWlqlavSLPTFLFFLLSwfvpesP 267
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 203 LIFVLRRSLQETEAFLQR------KHRPDTREIF-----ATIAKNW------------RIITAGTLLVAMTTTTFYfitv 259
Cdd:TIGR00898 268 RWLISQGRIEEALKILQRiakingKKLPAEVLSLslekdLSSSKKQysfldlfrtpnlRKTTLCLMMLWFTTAFSY---- 343
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 260 YTPTYGRTVLNLSARDSLIVTMLVGV-SNFI-WLPIggaisDRIGRRAVLMGITLLALITTWpVMQWLTAAPDFTRMTLV 337
Cdd:TIGR00898 344 YGLVLDLGNLGGNIYLDLFISGLVELpAKLItLLLI-----DRLGRRYTMAASLLLAGVALL-LLLFVPVDLYFLRTALA 417
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 338 LLWFSFFFGMYNGAMVAAlTEVMPVYVRTVGFSLAfSLATAIFGGLTPaistaLVKLTGDKSSPGWWLMCAALCGLAATA 417
Cdd:TIGR00898 418 VLGKFGITSAFQMVYLYT-AELYPTVVRNLGVGVC-STMARVGSIISP-----FLVYLGEKWLFLPLVLFGGLALLAGIL 490
|
410
....*....|....
gi 322634933 418 MLFVRLSRGYIAAE 431
Cdd:TIGR00898 491 TLFLPETKGVPLPE 504
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
33-207 |
9.96e-04 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 41.02 E-value: 9.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 33 LFGFYATYIAKTFFPAESEF----------ASLMLTFAVFGSGFlmrpvGAIVLGAYIDRIGRRKGLMVTLAIMGCGTLL 102
Cdd:cd17323 6 FLTFVVTFGSSIYSPALPQIaedfhvseevANLGVSLFVLGFGL-----GPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 103 IALVPGYQTIglaapalvLLGRLLQGFSAGVELGGVSVYLSEIATPGNKGFYTSWQSASQQVAIVVAALIGyslnitlgh 182
Cdd:cd17323 81 CALAPNIAML--------IILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIG--------- 143
|
170 180
....*....|....*....|....*.
gi 322634933 183 DAISE-WGWRIPFFIGCMIIPLIFVL 207
Cdd:cd17323 144 GFITQsLGWRWIFWFLAIISGFCLIL 169
|
|
| MFS_GLUT_Class1 |
cd17431 |
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
71-204 |
1.24e-03 |
|
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340989 [Multi-domain] Cd Length: 445 Bit Score: 40.78 E-value: 1.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 71 VGAIVLGAYIDRIGRRKGLMVT--LAIMGcgtlliALVPGYQTIGLAAPaLVLLGRLLQGFSAGVELGGVSVYLSEIATP 148
Cdd:cd17431 65 IGSFSVGLFVNRFGRRNSMLYNnlLAFAG------AALMGLSKLAKSYE-MLILGRFIIGLYCGLTTGLVPMYIGEISPT 137
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 322634933 149 GNKGFYTSWQSASQQVAIVVAALIGysLNITLGHDAisewGWriPFFIGCMIIPLI 204
Cdd:cd17431 138 ALRGALGTLHQLGIVVGILISQIFG--LEFILGTEE----LW--PLLLGFTIVPAI 185
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
32-351 |
1.73e-03 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 40.36 E-value: 1.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 32 FLFGFYATYIAKTFFpAESEFASLMLTFAVFGSGFLMRpvgaIVLGAYIDRIGRRKGLMVTLAIMGCGTLLIALVpgyqt 111
Cdd:TIGR00886 18 FAFSPLAVFLIKDDL-GLSTAQLGNLVAVPVLAGAVLR----IILGFLVDIFGPRYTTALSLLLLAIPCLWAGLA----- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 112 iGLAAPALVLLGrllqgFSAGVELGGVSVYLSEIATPGNK-------GFYTSWQSASQQVAIVVAALIGYSLNITLGHDA 184
Cdd:TIGR00886 88 -VQSYSVLLLIR-----LFIGIAGGSFASCMPWISFFFPKkiqgtalGLAAGWGNMGGGVAQFVMPPIIGSLIFGGGQPA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 185 ISEWGWRIPFFIGcMIIPLIFVLRRSLQETEAFLQRKHRPDTREIFATIAKNWRIItAGTLLVAMTTTTFYFITVYTPTY 264
Cdd:TIGR00886 162 HLAWGWAFVIVPA-GILLLPALLIFFVGADTPPGKPATGKLSFKEALKVFGNRHTW-ILALLYSVTFGSFLGVSSIFAML 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 265 GRTVLNLSARDSLIVTMLVGVSNFIWLPIGGAISDRIGRRAVLMGITLLALITTWPVMQWLTAAPDFTRMTLVLLWFSFF 344
Cdd:TIGR00886 240 FKDQFGLSKVQAGAYASLGGFLGSLARPAGGAISDRLGGARKLLMNFLGVAMGAFLVVLGLVSDGSLAAFIVLFVALFFF 319
|
....*..
gi 322634933 345 FGMYNGA 351
Cdd:TIGR00886 320 AGAGNGS 326
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
55-406 |
2.67e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 39.91 E-value: 2.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 55 LMLTFAVFGSgflmrpVGAIVLGAYIDRIGRRKGLMVTLAIMGCGTLLIALVPGYqtiglaapALVLLGRLLqgfsAGVE 134
Cdd:cd17328 39 LQTVFIISYM------VLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNF--------WQLLLFRAL----VGIG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 135 LGGVSV----YLSEIATPGNKGFYTSWQSAsqqvAIVVAALIGYSLNITLGHDAIS-EWGWRIPFFIGCMIIPLIFVLR- 208
Cdd:cd17328 101 EASYSPiaptIIADLFPKEKRTRALGVFYF----AIPLGSGLGYVVGGLVAQATGGwRWAFRVTGVLGVLLAILLLLFVr 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 209 --RSLQETEAFLQRKHRPDTREIFATIAKNWR--IITAGTLLVAMTTTTFYFITVYTPTYGRTVLNLS-ARDSLIVTMLV 283
Cdd:cd17328 177 epPRGAAEGGVMAKSTATSFLADLKALAKNPSfiLSTLGFTAVSFVTGALAFWAPTFFLRAFGVGDLSsADVGLIFGAIT 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 284 GVSNFIWLPIGGAISDRIGR-----RAVLMGITLLALITTWPVMqwLTAAPDFTRMTLVLLWFSFFFG-MYNGAMVAALT 357
Cdd:cd17328 257 CIAGVLGVLLGGILADRLRRktpraDPLVCAVGLLAAAPFLFLA--LVLALSNLLLAWVLLFLGEFLLsLNWAPVFAILL 334
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 322634933 358 EVMPVYVRTVGFSLAFSLATAIFGGLTPAISTALVKLTGDKSSPGWWLM 406
Cdd:cd17328 335 YVVIPTRRSTASAIQILLSHLLGDAGSPYLIGLISDLLRQNKDSPLAEA 383
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
71-302 |
2.89e-03 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 39.69 E-value: 2.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 71 VGAIVLGAYIDRIGRRKGLMVTLAIMGCGTLLIALVPGYqtiglaapALVLLGRLLQGFSAGVELGGVSVYLSEIATPGN 150
Cdd:PRK10091 53 VGAPIIALFSSRYSLKHILLFLVALCVIGNAMFTLSSSY--------LMLAIGRLVSGFPHGAFFGVGAIVLSKIIKPGK 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 151 kgfytswqsASQQVAIV-----VAALIGYSLNITLGHdaisEWGWRIPFF-IGCMIIPLIFVLRRSLQETEAFLQRKHRP 224
Cdd:PRK10091 125 ---------VTAAVAGMvsgmtVANLLGIPLGTYLSQ----EFSWRYTFLlIAVFNIAVLASIYFWVPDIRDEAKGGLRE 191
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 322634933 225 DTReiFATIAKNWRIITAGTLLVAMTTTTFYFITVYTptygRTVLNLSARDSLIVTMLVGVSNFIWLPIGGAISDRIG 302
Cdd:PRK10091 192 QFH--FLRSPAPWLIFAATMFGNAGVFAWFSYIKPYM----MFISGFSETSMTFIMMLVGLGMVLGNLLSGRLSGRYS 263
|
|
| MFS_GLUT8_Class3 |
cd17433 |
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
71-223 |
3.44e-03 |
|
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340991 [Multi-domain] Cd Length: 416 Bit Score: 39.47 E-value: 3.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 71 VGAIVLGAYIDRIGRRkglmvtLAIMGCGtllIALVPGYQTIGLAAPALVLL-GRLLQGFSAGVELGGVSVYLSEIATPG 149
Cdd:cd17433 56 AGGVLGGWIVDRAGRK------LSLMLCS---VPFIAGFTVITAAQNVWMLYvGRLLTGLASGVTSLVVPVYISEIAHPR 126
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 322634933 150 NKGFYTSWQSASQQVAIVVAALIGYSLNitlghdaisewgWRIPFFIGCMIIPLIFVLRRSLQETEAFLQRKHR 223
Cdd:cd17433 127 VRGTLGSCVQLMVVIGIMGAYLAGLVLD------------WRWLAVLGSIPPTLMLLLMCFMPETPRFLLTQHR 188
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
17-319 |
3.84e-03 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 39.53 E-value: 3.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 17 ILRVTSGNFLEQFDFFLFGFYATYIAKTFfPAESEFASLMLTFAVFgSGFLMRPVgaivLGAYIDR----IGRRKGLMVT 92
Cdd:cd17313 1 LFLLGFGFFGIEFGWALENSYVPPILQTL-GLSHALIGFVWTLGPI-LGLFVQPL----VGSLSDRcnsrIGRRRPFILV 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 93 LAIMGCgtLLIALVPGYQTIGLA--------APALVLLGRLLQGFSAGVELGGVSVYLSEIATPGNKGFYTSWQSASQQV 164
Cdd:cd17313 75 GAPLAA--LGLILIPNAADIGLAlgdgprtwALVLFVLGIVLLDFAMNVCQGPVRALLPDLVPPEQRSKANGIINFMGGL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 165 AIVVAALIGYSLNITLGHDAISEWGWRIPFFIG------CMIIPLIFVLRRSL-----QETEAFLQRKHRPDTREIFATI 233
Cdd:cd17313 153 GGVLGYLLGAILWDHNWFGFALGGNLKVPFYIGaiillvCVLVTLFFVKEPPLspeagEHSENPSLGEVLKSLLKLLKIM 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 234 AKNWRIITAGTLLVAMttTTFYFITVYT----------PTYGRTVLNLSARDSLIVTMLVGVSNFIWLPIGGAISDRIGR 303
Cdd:cd17313 233 PRSLLRLLLVIFFWWI--AFFPFELFFTdymgeevyhgTSAASSHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGR 310
|
330
....*....|....*..
gi 322634933 304 RAV-LMGITLLALITTW 319
Cdd:cd17313 311 KKVyLIGLVLFAVGMAL 327
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
32-170 |
4.58e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 38.94 E-value: 4.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 32 FLFGFYATYIAKTFFPAESEFA--SLMLTFAVFGSGFLMRPVGAIVLGAYIDRIGRRKGLMVTLAIMGCGTLLIALVPGY 109
Cdd:pfam07690 209 LLLFGFAFFGLLTYLPLYQEVLglSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLT 288
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 322634933 110 QTIGLAAPALVLLgrllqGFSAGVELGGVSVYLSEIATPGNKGFYTSWQSASQQVAIVVAA 170
Cdd:pfam07690 289 LSSLWLLLALLLL-----GFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
245-425 |
6.41e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 38.75 E-value: 6.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 245 LLVAMTTTTFYFITVYTPTYGRTVLNLSARDSLIVTMLVGVSNFIWLPIGGAISDRIGRRAVLMGITLLALIttwpVMQW 324
Cdd:cd17329 6 IGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRAL----GFAL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 325 LTAAPDFTRMTLVLLWFSFFFGMYNGAMVAALTEVMPVYVRTVGFSLaFSLATAIFGGLTPAISTALVKLtgdksSPGWW 404
Cdd:cd17329 82 LGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSL-LYWAINLGVAIGPLLGGLLLLY-----SFRLL 155
|
170 180
....*....|....*....|.
gi 322634933 405 LMCAALCGLAATAMLFVRLSR 425
Cdd:cd17329 156 FLAAAVLFLLAALVLLFLLPE 176
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
29-421 |
7.13e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 38.41 E-value: 7.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 29 FDFFLFGFYATYIAKTFF-PAESEFA-SLMLTFAVFGSGFLMRPVGAIVLGAYIDRIGRRKGLMVTLAIMGCGTLLIALV 106
Cdd:cd17355 9 FLILILSWGIRYYFGVFIiPIIAEFGwSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 107 PgyqtiglAAPALVLLGRLLQGFSAGVELGGVSVYLSEIATPGNKGFYTSWQSASQQVAIVVAALIGYSLnitlghdaIS 186
Cdd:cd17355 89 T-------SLWQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAAL--------IE 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 187 EWGWRIPF-----FIGCMIIPLIFVLRRSLQETEafLQRKHRPDTREIFATIAKNWR-----IITAGTLLVAMTTttfYF 256
Cdd:cd17355 154 AFGWRTALlvlalLALLVLVPVLLLLRRRPADLA--LRAYDDASPASPGSTLKEALRsasfwLLALAFFLCGFAV---VG 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 257 ITVYTPTYGRTvLNLSARDSLIVTMLVGVSNFIWLPIGGAISDRIGRRAVLMGITLLALITtwpvmqwLTAAPDFTRMTL 336
Cdd:cd17355 229 LIVHLVPYLAD-RGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALG-------LALLLLLPFPPL 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322634933 337 VLLWFSFFFGMYNGAMV---AALTEVM---PVYVRTVGFSLAFSLATAIFGgltPAISTALVKLTGDKSSPgwWLMCAAL 410
Cdd:cd17355 301 ALLLFAALFGLGWGATVpltAALAARYfgaRSYGTLFGLVFAPHQLGSALG---PWLGGLLYDRTGSYTAA--WALAVAL 375
|
410
....*....|.
gi 322634933 411 CGLAATAMLFV 421
Cdd:cd17355 376 GLIAALLVLPI 386
|
|
| |
