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Conserved domains on  [gi|323338448|gb|EGA79673|]
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Ubx3p [Saccharomyces cerevisiae Vin13]

Protein Classification

UAS and UBX domain-containing protein( domain architecture ID 10651955)

UAS and UBX domain-containing protein, may participate in the regulation of protein degradation; similar to Schizosaccharomyces pombe UBX domain-containing protein 10 (Ucp10) involved in protein degradation through the ubiquitin/proteasome pathway

PubMed:  11243799

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UAS smart00594
UAS domain;
24-147 1.08e-31

UAS domain;


:

Pssm-ID: 214737 [Multi-domain]  Cd Length: 122  Bit Score: 115.12  E-value: 1.08e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323338448    24 SLYNPEn*tFSKSIMQNSYTELLDACSEQVKFGVIYLHDPLLDNHMDYVNKILCSEAFVNMIRKyQVLLWYGDVTTSEGL 103
Cdd:smart00594   1 KLFRPP---YGPLFYQGSLEAAKQEASRQRRLLWLYLHSQDSPDSQVFNRDVLCNEAVKSLIRE-NFIFWQVDVDTSEGQ 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 323338448   104 QVSNALKIRQYPLLGIISLKA-EKKIELIARVEGSIS-NYKAQDLE 147
Cdd:smart00594  77 RVSQFYKLDSFPYVAIVDPRTgQRVIEWVGVVEGEISpEELMTFLE 122
UBX pfam00789
UBX domain; This domain is present in ubiquitin-regulatory proteins and is a general ...
 230-325 2.70e-16

UBX domain; This domain is present in ubiquitin-regulatory proteins and is a general Cdc48-interacting module.


:

Pssm-ID: 395637 [Multi-domain]  Cd Length: 80  Bit Score: 72.71  E-value: 2.70e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323338448  230 DKDASKVAIRLENGQRLVRKFDASLPTEEIYAFVELQLHDMLNsendtlpvyqpanyqhqySFKLITPVPRREL---DLS 306
Cdd:pfam00789   1 AEDVTRLQIRLPDGSRLVRRFNSSDKLQTVYDFVDSNRYDDLE------------------PFSLNTPFPRRPLtdlDYS 62

                          90
                  ....*....|....*....
gi 323338448  307 TKISDVsGIYPSGNIVMER 325
Cdd:pfam00789  63 KTLKEA-GLLPNSTLVLEP 80
DUF5401 super family cl38662
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 144-233 8.22e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


The actual alignment was detected with superfamily member pfam17380:

Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 41.26  E-value: 8.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323338448  144 QDLEAifSKNYSRLIQLRQ---QRQNIEMQRLIRQQQDSRYQDSLRRDQQRESErLEQTQREQMEREHQ--RIENQWLLW 218
Cdd:pfam17380 396 QELEA--ARKVKILEEERQrkiQQQKVEMEQIRAEQEEARQREVRRLEEERARE-MERVRLEEQERQQQveRLRQQEEER 472

                          90
                  ....*....|....*
gi 323338448  219 RKSQLKPEPSSDKDA 233
Cdd:pfam17380 473 KRKKLELEKEKRDRK 487
 
Name Accession Description Interval E-value
UAS smart00594
UAS domain;
24-147 1.08e-31

UAS domain;


Pssm-ID: 214737 [Multi-domain]  Cd Length: 122  Bit Score: 115.12  E-value: 1.08e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323338448    24 SLYNPEn*tFSKSIMQNSYTELLDACSEQVKFGVIYLHDPLLDNHMDYVNKILCSEAFVNMIRKyQVLLWYGDVTTSEGL 103
Cdd:smart00594   1 KLFRPP---YGPLFYQGSLEAAKQEASRQRRLLWLYLHSQDSPDSQVFNRDVLCNEAVKSLIRE-NFIFWQVDVDTSEGQ 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 323338448   104 QVSNALKIRQYPLLGIISLKA-EKKIELIARVEGSIS-NYKAQDLE 147
Cdd:smart00594  77 RVSQFYKLDSFPYVAIVDPRTgQRVIEWVGVVEGEISpEELMTFLE 122
UBX pfam00789
UBX domain; This domain is present in ubiquitin-regulatory proteins and is a general ...
 230-325 2.70e-16

UBX domain; This domain is present in ubiquitin-regulatory proteins and is a general Cdc48-interacting module.


Pssm-ID: 395637 [Multi-domain]  Cd Length: 80  Bit Score: 72.71  E-value: 2.70e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323338448  230 DKDASKVAIRLENGQRLVRKFDASLPTEEIYAFVELQLHDMLNsendtlpvyqpanyqhqySFKLITPVPRREL---DLS 306
Cdd:pfam00789   1 AEDVTRLQIRLPDGSRLVRRFNSSDKLQTVYDFVDSNRYDDLE------------------PFSLNTPFPRRPLtdlDYS 62

                          90
                  ....*....|....*....
gi 323338448  307 TKISDVsGIYPSGNIVMER 325
Cdd:pfam00789  63 KTLKEA-GLLPNSTLVLEP 80
UBX smart00166
Domain present in ubiquitin-regulatory proteins; Present in FAF1 and Shp1p.
 233-325 2.82e-16

Domain present in ubiquitin-regulatory proteins; Present in FAF1 and Shp1p.


Pssm-ID: 197552 [Multi-domain]  Cd Length: 77  Bit Score: 72.34  E-value: 2.82e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323338448   233 ASKVAIRLENGQRLVRKFDASLPTEEIYAFVelqlHDMLNSENDTlpvyqpanyqhqysFKLITPVPRREL---DLSTKI 309
Cdd:smart00166   1 VCRLQIRLPDGSRLVRRFPSSDTLRTVYEFV----SAALGDGNDP--------------FTLNSPFPRRTFtkdDYSKKL 62

                           90
                   ....*....|....*.
gi 323338448   310 SDVsGIYPSGNIVMER 325
Cdd:smart00166  63 LEL-ALLPSSTLVLEP 77
UAS_ETEA cd02991
UAS family, ETEA subfamily; composed of proteins similar to human ETEA protein, the ...
 39-146 1.34e-11

UAS family, ETEA subfamily; composed of proteins similar to human ETEA protein, the translation product of a highly expressed gene in the T-cells and eosinophils of atopic dermatitis patients compared with those of normal individuals. ETEA shows homology to Fas-associated factor 1 (FAF1); both containing UAS and UBX (ubiquitin-associated) domains. Compared to FAF1, however, ETEA lacks the ubiquitin-associated UBA domain and a nuclear targeting domain. The function of ETEA is still unknown. A yeast two-hybrid assay showed that it can interact with Fas. Because of its homology to FAF1, it is postulated that ETEA could be involved in modulating Fas-mediated apoptosis of T-cells and eosinophils of atopic dermatitis patients, making them more resistant to apoptosis.


Pssm-ID: 239289  Cd Length: 116  Bit Score: 60.57  E-value: 1.34e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323338448  39 QNSYTELLDACSEQVKFGVIYLHDPLLDNHMDYVNKILCSEAFVNMIRKyQVLLWYGDVTTSEGLQVSNALKIRQYPLLG 118
Cdd:cd02991    3 QGTYSQALNDAKQELRFLLVYLHGDDHQDTDEFCRNTLCAPEVIEYINT-RMLFWACSVAKPEGYRVSQALRERTYPFLA 81

                         90       100
                 ....*....|....*....|....*...
gi 323338448 119 IISLKAEKKIeLIARVEGSISnykAQDL 146
Cdd:cd02991   82 MIMLKDNRMT-IVGRLEGLIQ---PEDL 105
UBX cd01767
Ubiquitin regulatory domain X (UBX) structurally similar to a beta-grasp ubiquitin-like fold; ...
 235-324 5.43e-11

Ubiquitin regulatory domain X (UBX) structurally similar to a beta-grasp ubiquitin-like fold; The UBXD family of proteins contains the ubiquitin regulatory domain X (UBX) with a beta-grasp ubiquitin-like fold, but without the C-terminal double glycine motif. UBX domain is typically located at the carboxyl terminus of proteins, and participates broadly in the regulation of protein degradation. Members in this family function as cofactors of p97 (also known as VCP or Cdc48), which is a homohexameric AAA ATPase (ATPase associated with a variety of activities) involved in a variety of functions ranging from cell-cycle regulation to membrane fusion and protein degradation. Based on domain composition, UBXD proteins can be divided into two main groups, with and without ubiquitin-associated (UBA) domain.


Pssm-ID: 340466 [Multi-domain]  Cd Length: 74  Bit Score: 57.66  E-value: 5.43e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323338448 235 KVAIRLENGQRLVRKFDASLPTEEIYAFVELQLHDmlnsendtlpvyqpanyqHQYSFKLITPVPRREL---DLSTKISD 311
Cdd:cd01767    1 RIQIRLPDGSRIQRRFSKSDTLQDLYDFVESNLGD------------------SPSSFSLVTSFPRRVLtdeDSDKTLEE 62

                         90
                 ....*....|...
gi 323338448 312 VsGIYPSGNIVME 324
Cdd:cd01767   63 L-GLTPNAVLFVE 74
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 144-233 8.22e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 41.26  E-value: 8.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323338448  144 QDLEAifSKNYSRLIQLRQ---QRQNIEMQRLIRQQQDSRYQDSLRRDQQRESErLEQTQREQMEREHQ--RIENQWLLW 218
Cdd:pfam17380 396 QELEA--ARKVKILEEERQrkiQQQKVEMEQIRAEQEEARQREVRRLEEERARE-MERVRLEEQERQQQveRLRQQEEER 472

                          90
                  ....*....|....*
gi 323338448  219 RKSQLKPEPSSDKDA 233
Cdd:pfam17380 473 KRKKLELEKEKRDRK 487
 
Name Accession Description Interval E-value
UAS smart00594
UAS domain;
24-147 1.08e-31

UAS domain;


Pssm-ID: 214737 [Multi-domain]  Cd Length: 122  Bit Score: 115.12  E-value: 1.08e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323338448    24 SLYNPEn*tFSKSIMQNSYTELLDACSEQVKFGVIYLHDPLLDNHMDYVNKILCSEAFVNMIRKyQVLLWYGDVTTSEGL 103
Cdd:smart00594   1 KLFRPP---YGPLFYQGSLEAAKQEASRQRRLLWLYLHSQDSPDSQVFNRDVLCNEAVKSLIRE-NFIFWQVDVDTSEGQ 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 323338448   104 QVSNALKIRQYPLLGIISLKA-EKKIELIARVEGSIS-NYKAQDLE 147
Cdd:smart00594  77 RVSQFYKLDSFPYVAIVDPRTgQRVIEWVGVVEGEISpEELMTFLE 122
UBX pfam00789
UBX domain; This domain is present in ubiquitin-regulatory proteins and is a general ...
 230-325 2.70e-16

UBX domain; This domain is present in ubiquitin-regulatory proteins and is a general Cdc48-interacting module.


Pssm-ID: 395637 [Multi-domain]  Cd Length: 80  Bit Score: 72.71  E-value: 2.70e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323338448  230 DKDASKVAIRLENGQRLVRKFDASLPTEEIYAFVELQLHDMLNsendtlpvyqpanyqhqySFKLITPVPRREL---DLS 306
Cdd:pfam00789   1 AEDVTRLQIRLPDGSRLVRRFNSSDKLQTVYDFVDSNRYDDLE------------------PFSLNTPFPRRPLtdlDYS 62

                          90
                  ....*....|....*....
gi 323338448  307 TKISDVsGIYPSGNIVMER 325
Cdd:pfam00789  63 KTLKEA-GLLPNSTLVLEP 80
UBX smart00166
Domain present in ubiquitin-regulatory proteins; Present in FAF1 and Shp1p.
 233-325 2.82e-16

Domain present in ubiquitin-regulatory proteins; Present in FAF1 and Shp1p.


Pssm-ID: 197552 [Multi-domain]  Cd Length: 77  Bit Score: 72.34  E-value: 2.82e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323338448   233 ASKVAIRLENGQRLVRKFDASLPTEEIYAFVelqlHDMLNSENDTlpvyqpanyqhqysFKLITPVPRREL---DLSTKI 309
Cdd:smart00166   1 VCRLQIRLPDGSRLVRRFPSSDTLRTVYEFV----SAALGDGNDP--------------FTLNSPFPRRTFtkdDYSKKL 62

                           90
                   ....*....|....*.
gi 323338448   310 SDVsGIYPSGNIVMER 325
Cdd:smart00166  63 LEL-ALLPSSTLVLEP 77
UAS_ETEA cd02991
UAS family, ETEA subfamily; composed of proteins similar to human ETEA protein, the ...
 39-146 1.34e-11

UAS family, ETEA subfamily; composed of proteins similar to human ETEA protein, the translation product of a highly expressed gene in the T-cells and eosinophils of atopic dermatitis patients compared with those of normal individuals. ETEA shows homology to Fas-associated factor 1 (FAF1); both containing UAS and UBX (ubiquitin-associated) domains. Compared to FAF1, however, ETEA lacks the ubiquitin-associated UBA domain and a nuclear targeting domain. The function of ETEA is still unknown. A yeast two-hybrid assay showed that it can interact with Fas. Because of its homology to FAF1, it is postulated that ETEA could be involved in modulating Fas-mediated apoptosis of T-cells and eosinophils of atopic dermatitis patients, making them more resistant to apoptosis.


Pssm-ID: 239289  Cd Length: 116  Bit Score: 60.57  E-value: 1.34e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323338448  39 QNSYTELLDACSEQVKFGVIYLHDPLLDNHMDYVNKILCSEAFVNMIRKyQVLLWYGDVTTSEGLQVSNALKIRQYPLLG 118
Cdd:cd02991    3 QGTYSQALNDAKQELRFLLVYLHGDDHQDTDEFCRNTLCAPEVIEYINT-RMLFWACSVAKPEGYRVSQALRERTYPFLA 81

                         90       100
                 ....*....|....*....|....*...
gi 323338448 119 IISLKAEKKIeLIARVEGSISnykAQDL 146
Cdd:cd02991   82 MIMLKDNRMT-IVGRLEGLIQ---PEDL 105
UBX cd01767
Ubiquitin regulatory domain X (UBX) structurally similar to a beta-grasp ubiquitin-like fold; ...
 235-324 5.43e-11

Ubiquitin regulatory domain X (UBX) structurally similar to a beta-grasp ubiquitin-like fold; The UBXD family of proteins contains the ubiquitin regulatory domain X (UBX) with a beta-grasp ubiquitin-like fold, but without the C-terminal double glycine motif. UBX domain is typically located at the carboxyl terminus of proteins, and participates broadly in the regulation of protein degradation. Members in this family function as cofactors of p97 (also known as VCP or Cdc48), which is a homohexameric AAA ATPase (ATPase associated with a variety of activities) involved in a variety of functions ranging from cell-cycle regulation to membrane fusion and protein degradation. Based on domain composition, UBXD proteins can be divided into two main groups, with and without ubiquitin-associated (UBA) domain.


Pssm-ID: 340466 [Multi-domain]  Cd Length: 74  Bit Score: 57.66  E-value: 5.43e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323338448 235 KVAIRLENGQRLVRKFDASLPTEEIYAFVELQLHDmlnsendtlpvyqpanyqHQYSFKLITPVPRREL---DLSTKISD 311
Cdd:cd01767    1 RIQIRLPDGSRIQRRFSKSDTLQDLYDFVESNLGD------------------SPSSFSLVTSFPRRVLtdeDSDKTLEE 62

                         90
                 ....*....|...
gi 323338448 312 VsGIYPSGNIVME 324
Cdd:cd01767   63 L-GLTPNAVLFVE 74
UAS cd02958
UAS family; UAS is a domain of unknown function. Most members of this family are ...
 45-136 5.45e-07

UAS family; UAS is a domain of unknown function. Most members of this family are uncharacterized proteins with similarity to FAS-associated factor 1 (FAF1) and ETEA because of the presence of a UAS domain N-terminal to a ubiquitin-associated UBX domain. FAF1 is a longer protein, compared to the other members of this family, having additional N-terminal domains, a ubiquitin-associated UBA domain and a nuclear targeting domain. FAF1 is an apoptotic signaling molecule that acts downstream in the Fas signal transduction pathway. It interacts with the cytoplasmic domain of Fas, but not to a Fas mutant that is deficient in signal transduction. ETEA is the protein product of a highly expressed gene in T-cells and eosinophils of atopic dermatitis patients. The presence of the ubiquitin-associated UBX domain in the proteins of this family suggests the possibility of their involvement in ubiquitination. Recently, FAF1 has been shown to interact with valosin-containing protein (VCP), which is involved in the ubiquitin-proteosome pathway. Some members of this family are uncharacterized proteins containing only a UAS domain.


Pssm-ID: 239256 [Multi-domain]  Cd Length: 114  Bit Score: 47.60  E-value: 5.45e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323338448  45 LLDACSEQvKFGVIYLHDpllDNHMDyVNK----ILCSEAFVNMIRKYQVLlWYGDVTTSEGLQVSNALKIRQYPLLGII 120
Cdd:cd02958   10 KQEAKSEK-KWLLVYLQS---EDEFD-SQVlnrdLWSNESVKEFIRENFIF-WQCDIDSSEGQRFLQSYKVDKYPHIAII 83

                         90
                 ....*....|....*.
gi 323338448 121 SLKAEKKIELIARVEG 136
Cdd:cd02958   84 DPRTGEVLKVWSGNIT 99
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 144-233 8.22e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 41.26  E-value: 8.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323338448  144 QDLEAifSKNYSRLIQLRQ---QRQNIEMQRLIRQQQDSRYQDSLRRDQQRESErLEQTQREQMEREHQ--RIENQWLLW 218
Cdd:pfam17380 396 QELEA--ARKVKILEEERQrkiQQQKVEMEQIRAEQEEARQREVRRLEEERARE-MERVRLEEQERQQQveRLRQQEEER 472

                          90
                  ....*....|....*
gi 323338448  219 RKSQLKPEPSSDKDA 233
Cdd:pfam17380 473 KRKKLELEKEKRDRK 487
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 156-222 3.18e-03

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 39.16  E-value: 3.18e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 323338448  156 RLIQLRQQRQNIEMQRLIRQQQDSR---YQDSLRRDQQRESE--RLEQtQREQMEREHQRIE--NQWLLWRKSQ 222
Cdd:pfam15709 346 RRLEVERKRREQEEQRRLQQEQLERaekMREELELEQQRRFEeiRLRK-QRLEEERQRQEEEerKQRLQLQAAQ 418
UBX_UBXN3B cd16120
Ubiquitin regulatory domain X (UBX) found in FAS associated factor 2 (FAF2, also known as ...
 235-303 5.27e-03

Ubiquitin regulatory domain X (UBX) found in FAS associated factor 2 (FAF2, also known as UBXN3B) and similar proteins; UBX domain-containing protein 3B (UBXN3B), also termed protein ETEA, or FAF2, or UBX domain-containing protein 8 (UBXD8), belongs to the UBXD family of proteins that contains the ubiquitin regulatory domain X (UBX) with a beta-grasp ubiquitin-like fold, but without the C-terminal double glycine motif. UBX domain is typically located at the carboxyl terminus of proteins, and participates broadly in the regulation of protein degradation. FAF2 functions as a cofactor of p97 (also known as VCP or Cdc48), which is a homohexameric AAA ATPase (ATPase associated with a variety of activities) involved in a variety of functions ranging from cell-cycle regulation to membrane fusion and protein degradation. The p97-UBXD8 complex destabilizes mRNA by promoting release of ubiquitinated the RNA-binding protein HuR from messenger ribonucleoprotein (mRNP). Moreover, FAF2 is the translation product of a highly expressed gene in the T-cells and eosinophils of atopic dermatitis patients compared with those of normal individuals. A yeast two-hybrid assay showed that FAF2 can interact with Fas.


Pssm-ID: 340537  Cd Length: 80  Bit Score: 35.33  E-value: 5.27e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 323338448 235 KVAIRLENGQRLVRKFDASLPTEEIYAFVElqLHDMLNSEndtlpvyqpanyqhqysFKLITPVPRREL 303
Cdd:cd16120    2 KILFKLPNGTRLERRFLKSDSLKVLYDFVF--SHEDSPDK-----------------FQLVTNFPRRVL 51
RRP36 pfam06102
rRNA biogenesis protein RRP36; RRP36 is involved in the early processing steps of the pre-rRNA.
 147-207 7.09e-03

rRNA biogenesis protein RRP36; RRP36 is involved in the early processing steps of the pre-rRNA.


Pssm-ID: 461829 [Multi-domain]  Cd Length: 158  Bit Score: 36.77  E-value: 7.09e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 323338448  147 EAIFSKNYSRLIQLRQQrQNIEMQRLIRQQQDSRYQDSLRRDQQRESERLEQTQREQMERE 207
Cdd:pfam06102  44 EDKFRKNYGFLDEYRKK-EIEELKKQLKKTKDPEEKEELKRTLQSMESRLKAKKRKDRERE 103
UBX_UBXN1 cd01772
Ubiquitin regulatory domain X (UBX) found in UBX domain protein 1 (UBXN1) and similar proteins; ...
 230-323 8.48e-03

Ubiquitin regulatory domain X (UBX) found in UBX domain protein 1 (UBXN1) and similar proteins; UBXN1, also termed SAPK substrate protein 1 (SAKS1), UBA/UBX 33.3 kDa protein (Y33K), or UBXD10, is a widely expressed protein containing an N-terminal ubiquitin-associated (UBA) domain, a coiled-coil region, and a C-terminal ubiquitin-like (Ubl or UBX) domain that has a beta-grasp ubiquitin-like fold without the C-terminal double glycine motif. UBXN1 has been identified as a substrate for stress-activated protein kinases (SAPKs). It binds polyubiquitin and valosin-containing protein (VCP), suggesting a role as an adaptor that directs VCP to polyubiquitinated proteins facilitating its destruction by the proteasome. In addition, UBXN1 specifically binds to Homer2b. It may also interact with ubiquitin (Ub) and be involved in the Ub-proteasome proteolytic pathways. UBXN1 can also associate with autoubiquitinated BRCA1 tumor suppressor and inhibit its enzymatic function through its UBA domains.


Pssm-ID: 340470 [Multi-domain]  Cd Length: 81  Bit Score: 34.98  E-value: 8.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323338448 230 DKDASKVAIRLENGQRLVRKFDASLPTEEIYAFVElqlhdmLNSENDTLPvyqpanyqhqysFKLITPVPRR---ELDLS 306
Cdd:cd01772    3 EYDECRLQVRLTNGSTLTQTFGAKEQLAAVRLYVE------LNRTDGDGP------------FSLMTTFPRKvftEEDME 64

                         90
                 ....*....|....*..
gi 323338448 307 TKISDVsGIYPSGNIVM 323
Cdd:cd01772   65 KPLKEL-GLVPSAVLIV 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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