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Conserved domains on  [gi|324990007|gb|EGC21948|]
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hypothetical protein HMPREF9388_1716 [Streptococcus sanguinis SK353]

Protein Classification

kinase( domain architecture ID 10012812)

putative kinase containing a P-loop motif associated with NTP hydrolysis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK06762 PRK06762
hypothetical protein; Provisional
 1-166 5.55e-96

hypothetical protein; Provisional


:

Pssm-ID: 235858  Cd Length: 166  Bit Score: 274.92  E-value: 5.55e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324990007   1 MAKLVIIRGNSGSGKSSLARKLQAHYGRGTLLIAQDTIRRDMLKEKVEPGNLSIDLTETLAHFGYEHDLLVLVEGFYETD 80
Cdd:PRK06762   1 MTTLIIIRGNSGSGKTTIAKQLQERLGRGTLLVSQDVVRRDMLRVKDGPGNLSIDLIEQLVRYGLGHCEFVILEGILNSD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324990007  81 IYGQMLERLKKIFAPQVFAYYYDLSFEETVRRHQTRAKQEEFTPADMKRWWKDRDFLGWEEEAFFTDEDSLEAAFDKICS 160
Cdd:PRK06762  81 RYGPMLKELIHLFRGNAYTYYFDLSFEETLRRHSTRPKSHEFGEDDMRRWWNPHDTLGVIGETIFTDNLSLKDIFDAILT 160


                 ....*.
gi 324990007 161 ALDKKD 166
Cdd:PRK06762 161 DIGLRK 166
 
Name Accession Description Interval E-value
PRK06762 PRK06762
hypothetical protein; Provisional
 1-166 5.55e-96

hypothetical protein; Provisional


Pssm-ID: 235858  Cd Length: 166  Bit Score: 274.92  E-value: 5.55e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324990007   1 MAKLVIIRGNSGSGKSSLARKLQAHYGRGTLLIAQDTIRRDMLKEKVEPGNLSIDLTETLAHFGYEHDLLVLVEGFYETD 80
Cdd:PRK06762   1 MTTLIIIRGNSGSGKTTIAKQLQERLGRGTLLVSQDVVRRDMLRVKDGPGNLSIDLIEQLVRYGLGHCEFVILEGILNSD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324990007  81 IYGQMLERLKKIFAPQVFAYYYDLSFEETVRRHQTRAKQEEFTPADMKRWWKDRDFLGWEEEAFFTDEDSLEAAFDKICS 160
Cdd:PRK06762  81 RYGPMLKELIHLFRGNAYTYYFDLSFEETLRRHSTRPKSHEFGEDDMRRWWNPHDTLGVIGETIFTDNLSLKDIFDAILT 160


                 ....*.
gi 324990007 161 ALDKKD 166
Cdd:PRK06762 161 DIGLRK 166
COG4639 COG4639
Predicted kinase [General function prediction only];
1-144 1.16e-10

Predicted kinase [General function prediction only];


Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 56.38  E-value: 1.16e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324990007   1 MAKLVIIRGNSGSGKSSLARKLQAhygrGTLLIAQDTIRRDMlkeKVEPGNLS-----IDLTETLAHFGYEHDLLVLVEG 75
Cdd:COG4639    1 MLSLVVLIGLPGSGKSTFARRLFA----PTEVVSSDDIRALL---GGDENDQSawgdvFQLAHEIARARLRAGRLTVVDA 73

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 324990007  76 fyeTDIYGQMLERLKKIFA---PQVFAYYYDLSFEETVRRHQTRAKQeeFTPADMKRWWKDRDFLGWEEEAF 144
Cdd:COG4639   74 ---TNLQREARRRLLALARaygALVVAVVLDVPLEVCLARNAARDRQ--VPEEVIRRMLRRLRRPPLPEEGF 140
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 4-76 8.08e-06

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 43.45  E-value: 8.08e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 324990007    4 LVIIRGNSGSGKSSLARKLqaHYGRGTLLIAQDTIRRDMLKEKVEPGNLSIDLTETLAHFGYEHDLLVLVEGF 76
Cdd:pfam13671   1 LILLVGLPGSGKSTLARRL--LEELGAVRLSSDDERKRLFGEGRPSISYYTDATDRTYERLHELARIALRAGR 71
UMPK_like cd02028
Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the ...
 4-51 1.06e-04

Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK).


Pssm-ID: 238986 [Multi-domain]  Cd Length: 179  Bit Score: 40.75  E-value: 1.06e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 324990007   4 LVIIRGNSGSGKSSLARKLQAH---YGRGTLLIAQDTIRRDMLKEKVEPGN 51
Cdd:cd02028    1 VVGIAGPSGSGKTTFAKKLSNQlrvNGIGPVVISLDDYYVPRKTPRDEDGN 51
 
Name Accession Description Interval E-value
PRK06762 PRK06762
hypothetical protein; Provisional
 1-166 5.55e-96

hypothetical protein; Provisional


Pssm-ID: 235858  Cd Length: 166  Bit Score: 274.92  E-value: 5.55e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324990007   1 MAKLVIIRGNSGSGKSSLARKLQAHYGRGTLLIAQDTIRRDMLKEKVEPGNLSIDLTETLAHFGYEHDLLVLVEGFYETD 80
Cdd:PRK06762   1 MTTLIIIRGNSGSGKTTIAKQLQERLGRGTLLVSQDVVRRDMLRVKDGPGNLSIDLIEQLVRYGLGHCEFVILEGILNSD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324990007  81 IYGQMLERLKKIFAPQVFAYYYDLSFEETVRRHQTRAKQEEFTPADMKRWWKDRDFLGWEEEAFFTDEDSLEAAFDKICS 160
Cdd:PRK06762  81 RYGPMLKELIHLFRGNAYTYYFDLSFEETLRRHSTRPKSHEFGEDDMRRWWNPHDTLGVIGETIFTDNLSLKDIFDAILT 160


                 ....*.
gi 324990007 161 ALDKKD 166
Cdd:PRK06762 161 DIGLRK 166
COG4639 COG4639
Predicted kinase [General function prediction only];
1-144 1.16e-10

Predicted kinase [General function prediction only];


Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 56.38  E-value: 1.16e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324990007   1 MAKLVIIRGNSGSGKSSLARKLQAhygrGTLLIAQDTIRRDMlkeKVEPGNLS-----IDLTETLAHFGYEHDLLVLVEG 75
Cdd:COG4639    1 MLSLVVLIGLPGSGKSTFARRLFA----PTEVVSSDDIRALL---GGDENDQSawgdvFQLAHEIARARLRAGRLTVVDA 73

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 324990007  76 fyeTDIYGQMLERLKKIFA---PQVFAYYYDLSFEETVRRHQTRAKQeeFTPADMKRWWKDRDFLGWEEEAF 144
Cdd:COG4639   74 ---TNLQREARRRLLALARaygALVVAVVLDVPLEVCLARNAARDRQ--VPEEVIRRMLRRLRRPPLPEEGF 140
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
4-158 1.05e-09

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 54.15  E-value: 1.05e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324990007   4 LVIIRGNSGSGKSSLARKLQAHygRGTLLIAQDTIRRDMLKEKVEPGNLSIDLTETLahfgYEH------DLL------V 71
Cdd:COG0645    1 LILVCGLPGSGKSTLARALAER--LGAVRLRSDVVRKRLFGAGLAPLERSPEATART----YARllalarELLaagrsvI 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324990007  72 LVEGFYETDIYGQMLERLKKIFAPqVFAYYYDLSFEETVRRHQTRAKQ---EEFTPADMKRWWKDRDFLGWEEEAFFT-D 147
Cdd:COG0645   75 LDATFLRRAQREAFRALAEEAGAP-FVLIWLDAPEEVLRERLEARNAEggdSDATWEVLERQLAFEEPLTEDEGFLLVvD 153

                        170
                 ....*....|.
gi 324990007 148 EDSLEAAFDKI 158
Cdd:COG0645  154 TSGLEEALAAL 164
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 4-76 8.08e-06

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 43.45  E-value: 8.08e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 324990007    4 LVIIRGNSGSGKSSLARKLqaHYGRGTLLIAQDTIRRDMLKEKVEPGNLSIDLTETLAHFGYEHDLLVLVEGF 76
Cdd:pfam13671   1 LILLVGLPGSGKSTLARRL--LEELGAVRLSSDDERKRLFGEGRPSISYYTDATDRTYERLHELARIALRAGR 71
UMPK_like cd02028
Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the ...
 4-51 1.06e-04

Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK).


Pssm-ID: 238986 [Multi-domain]  Cd Length: 179  Bit Score: 40.75  E-value: 1.06e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 324990007   4 LVIIRGNSGSGKSSLARKLQAH---YGRGTLLIAQDTIRRDMLKEKVEPGN 51
Cdd:cd02028    1 VVGIAGPSGSGKTTFAKKLSNQlrvNGIGPVVISLDDYYVPRKTPRDEDGN 51
HprK COG1493
Serine kinase of the HPr protein, regulates carbohydrate metabolism [Signal transduction ...
 5-41 1.22e-03

Serine kinase of the HPr protein, regulates carbohydrate metabolism [Signal transduction mechanisms];


Pssm-ID: 441102 [Multi-domain]  Cd Length: 142  Bit Score: 37.08  E-value: 1.22e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 324990007   5 VIIRGNSGSGKSSLARKLQAhygRGTLLIAQD--TIRRD 41
Cdd:COG1493   14 VLITGPSGSGKSELALELIK---RGHRLVADDrvELRRE 49
uvrA PRK00349
excinuclease ABC subunit UvrA;
3-19 4.08e-03

excinuclease ABC subunit UvrA;


Pssm-ID: 234734 [Multi-domain]  Cd Length: 943  Bit Score: 36.97  E-value: 4.08e-03
                         10
                 ....*....|....*..
gi 324990007   3 KLVIIRGNSGSGKSSLA 19
Cdd:PRK00349  27 KLVVFTGLSGSGKSSLA 43
UvrA COG0178
Excinuclease UvrABC ATPase subunit [Replication, recombination and repair];
3-19 4.22e-03

Excinuclease UvrABC ATPase subunit [Replication, recombination and repair];


Pssm-ID: 439948 [Multi-domain]  Cd Length: 941  Bit Score: 36.93  E-value: 4.22e-03
                         10
                 ....*....|....*..
gi 324990007   3 KLVIIRGNSGSGKSSLA 19
Cdd:COG0178   27 KLVVITGLSGSGKSSLA 43
PRK07261 PRK07261
DNA topology modulation protein;
3-26 5.39e-03

DNA topology modulation protein;


Pssm-ID: 180911 [Multi-domain]  Cd Length: 171  Bit Score: 35.85  E-value: 5.39e-03
                         10        20
                 ....*....|....*....|....
gi 324990007   3 KLVIIrGNSGSGKSSLARKLQAHY 26
Cdd:PRK07261   2 KIAII-GYSGSGKSTLARKLSQHY 24
HprK_C cd01918
HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the ...
 5-38 7.65e-03

HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent phosphorylation of Ser-46 of HPr and its dephosphorylation by phosphorolysis. The latter reaction uses inorganic phosphate as substrate and produces pyrophosphate. Phosphoenolpyruvate carboxykinase (PEPCK) and the C-terminal catalytic domain of HprK/P are structurally similar with conserved active site residues suggesting these two phosphotransferases have related functions. The HprK/P N-terminal domain is structurally similar to the N-terminal domains of the MurE and MurF amino acid ligases.


Pssm-ID: 238899  Cd Length: 149  Bit Score: 34.90  E-value: 7.65e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 324990007   5 VIIRGNSGSGKSSLARKLqahYGRGTLLIAQDTI 38
Cdd:cd01918   17 VLITGPSGIGKSELALEL---IKRGHRLVADDRV 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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