NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|327549383|gb|EGF33950|]
View 

MFS superfamily drug efflux transporter [Oxalobacteraceae bacterium IMCC9480]

Protein Classification

MFS transporter( domain architecture ID 1001490)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
PRK10504 super family cl32521
putative transporter; Provisional
10-445 2.25e-90

putative transporter; Provisional


The actual alignment was detected with superfamily member PRK10504:

Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 283.16  E-value: 2.25e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  10 DNSAIKRYLPWVVATALFMEQLDSTIINTAVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAV 89
Cdd:PRK10504   3 DLPDSVRWQLWIVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAI 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  90 AIFTFASVLCGLSQNVPMLVAARILQGMGAAMMMPVGRLTIVRTFPKFELLRAMNFVIIPALIGPLLGPTIGGLIVHVTS 169
Cdd:PRK10504  83 VLFTLGSLFCALSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYAS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 170 WRVIFFVNVPVGLAAQWLIHKHMPDYHGDaPRPLDVVGMVLFGTGTALLSWLLEIFGEHKLDATSTGVLLLLALSLLATY 249
Cdd:PRK10504 163 WHWIFLINIPVGIIGAIATLMLMPNYTMQ-TRRFDLSGFLLLAVGMATLTLALDGSKGLGLSPLAIAGLVAVGVVALLLY 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 250 VWHAGRIASPLLRLALFRVRTFRVSVVGGFVTRLGLGGLPFLLPLLYQLGLGLPAWQSGLLMMPAAAGAMGMKLMAARLL 329
Cdd:PRK10504 242 LLHARNNNRALFSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVV 321
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 330 KRFGYRQVLIINTVLIGATISLFATVSTSTPLALIVLLGLTQGVFNSLQFSSMNSMAYADISSADTSMASTLASSLQQMS 409
Cdd:PRK10504 322 NRFGYRRVLVATTLGLALVSLLFMLVALLGWYYLLPFVLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQLS 401
                        410       420       430
                 ....*....|....*....|....*....|....*.
gi 327549383 410 MSFGLAcgslVTGWYLGDLPESNRLAVTSALHHAFL 445
Cdd:PRK10504 402 MSIGVT----IAGLLLGLFGQQHVSVDSGATHTVFM 433
 
Name Accession Description Interval E-value
PRK10504 PRK10504
putative transporter; Provisional
10-445 2.25e-90

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 283.16  E-value: 2.25e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  10 DNSAIKRYLPWVVATALFMEQLDSTIINTAVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAV 89
Cdd:PRK10504   3 DLPDSVRWQLWIVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAI 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  90 AIFTFASVLCGLSQNVPMLVAARILQGMGAAMMMPVGRLTIVRTFPKFELLRAMNFVIIPALIGPLLGPTIGGLIVHVTS 169
Cdd:PRK10504  83 VLFTLGSLFCALSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYAS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 170 WRVIFFVNVPVGLAAQWLIHKHMPDYHGDaPRPLDVVGMVLFGTGTALLSWLLEIFGEHKLDATSTGVLLLLALSLLATY 249
Cdd:PRK10504 163 WHWIFLINIPVGIIGAIATLMLMPNYTMQ-TRRFDLSGFLLLAVGMATLTLALDGSKGLGLSPLAIAGLVAVGVVALLLY 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 250 VWHAGRIASPLLRLALFRVRTFRVSVVGGFVTRLGLGGLPFLLPLLYQLGLGLPAWQSGLLMMPAAAGAMGMKLMAARLL 329
Cdd:PRK10504 242 LLHARNNNRALFSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVV 321
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 330 KRFGYRQVLIINTVLIGATISLFATVSTSTPLALIVLLGLTQGVFNSLQFSSMNSMAYADISSADTSMASTLASSLQQMS 409
Cdd:PRK10504 322 NRFGYRRVLVATTLGLALVSLLFMLVALLGWYYLLPFVLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQLS 401
                        410       420       430
                 ....*....|....*....|....*....|....*.
gi 327549383 410 MSFGLAcgslVTGWYLGDLPESNRLAVTSALHHAFL 445
Cdd:PRK10504 402 MSIGVT----IAGLLLGLFGQQHVSVDSGATHTVFM 433
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
22-462 7.12e-75

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 240.17  E-value: 7.12e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  22 VATALFMEQLDSTIINTAVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLCGL 101
Cdd:cd17503    1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 102 SQNVPMLVAARILQGMGAAMMMPVGRLTIVRTFPKFELLRAMNFVIIPALIGPLLGPTIGGLIVHVTSWRVIFFVNVPVG 181
Cdd:cd17503   81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 182 LAAQWLIhkhmpdyhgdaprpldvvgmvlfgtgtallswlleifgehkldatstgvllllalsllatyvwhagriasPLL 261
Cdd:cd17503  161 ILALLLA----------------------------------------------------------------------PLL 170
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 262 RLALFRVRTFRVSVVGGFVTRLGLGGLPFLLPLLYQLGLGLPAWQSGLLMMPAAAGAMGMKLMAARLLKRFGYRQVLIIN 341
Cdd:cd17503  171 DLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAG 250
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 342 TVLIGATISLFATVSTSTPLALIVLLGLTQGVFNSLQFSSMNSMAYADISSADTSMASTLASSLQQMSMSFGLACGSLV- 420
Cdd:cd17503  251 LLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLl 330
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|
gi 327549383 421 ---TGWYLGDLPE-----SNRLAVTSALHHAFLTLGVMTVLSSLSFRTLK 462
Cdd:cd17503  331 tnrTQFHHSRLSEllaqqVQKQALIIAFNDAFLVSAILLLVGLLLALFLR 380
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
25-415 7.56e-51

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 179.88  E-value: 7.56e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383   25 ALFMEQLDSTIINTAVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLCGLSQN 104
Cdd:TIGR00711  10 GTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPN 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  105 VPMLVAARILQGMGAAMMMPVGRLTIVRTFPKFELLRAMNFVIIPALIGPLLGPTIGGLIVHVTSWRVIFFVNVPVGLAA 184
Cdd:TIGR00711  90 LELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIV 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  185 QWLIHKHMPDYHGDAPRPLDVVGMVLFGTGTALLSWLLEIFGEHK-LDATSTGVLLLLALSLLATYVWHAGRIASPLLRL 263
Cdd:TIGR00711 170 VVVAFFILPRDKPAASENFDFLGLLLLSVGLGSLLYGLSEGPERGwFDSNEILILSITGLVAIIAFVVWELTDDNPLVDL 249
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  264 ALFRVRTFRVSVVGGFVTRLGLGGLPFLLPLLYQLGLGLPAWQSGLLMMPAAAGAMGMKLMAARLLKRFGYRQVLIINTV 343
Cdd:TIGR00711 250 RLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLVTIGLI 329
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 327549383  344 LIGATISLFA-TVSTSTPLALIVLLGLTQGVFNSLQFSSMNSMAYADISSADTSMASTLASSLQQMSMSFGLA 415
Cdd:TIGR00711 330 LYAVGFYWRAfTFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGTA 402
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
9-411 5.17e-35

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 133.56  E-value: 5.17e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383   9 ADNSAIKRYLPWVVATALFMEQLDSTIINTAVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTA 88
Cdd:COG2814    2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  89 VAIFTFASVLCGLSQNVPMLVAARILQGMGAAMMMPVGRLTIVRTFPKFELLRAMNFVIIPALIGPLLGPTIGGLIVHVT 168
Cdd:COG2814   82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 169 SWRVIFFVNVPVGLAAQWLIHKHMPDYHGDAPRPLDVVgmvlfgtgtallswlleifgehkldatstgvllllalsllat 248
Cdd:COG2814  162 GWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGS------------------------------------------ 199
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 249 yvwhagriaspllRLALFRVRTFRVSVVGGFVTRLGLGGLPFLLPLLYQLGLGLPAWQSGLLMMPAAAGAMGMKLMAARL 328
Cdd:COG2814  200 -------------LRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRL 266
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 329 LKRFGYRQVLIINTVLIGATISLFATVSTstpLALIVLLGLTQGVFNSLQFSSMNSMAYADISSADTSMASTLASSLQQM 408
Cdd:COG2814  267 ADRFGRRRLLLIGLLLLALGLLLLALAGS---LWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343

                 ...
gi 327549383 409 SMS 411
Cdd:COG2814  344 GGP 346
MFS_1 pfam07690
Major Facilitator Superfamily;
22-413 2.05e-21

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 95.18  E-value: 2.05e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383   22 VATALFMEQLDSTIINTAVPS-MAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLCG 100
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  101 LSQNVPMLVAARILQGMGAAMMMPVGRLTIVRTFPKFELLRAMNFVIIPALIGPLLGPTIGGLIVHVTSWRVIFFVNVPV 180
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  181 GLAAqwlihkhmpdyhgdaprpldvvgmvlfgtgtALLSWLLEIFGEHKLDATstgvllllalsllatyvWHAGRIASPL 260
Cdd:pfam07690 161 SLLA-------------------------------AVLLLLPRPPPESKRPKP-----------------AEEARLSLIV 192
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  261 LRLALFRVRTFRVSVVggFVTRLGLGGLPFLLPLLYQLGLGLPAWQSGLLMMPAAAGAMGMKLMAARLLKRFGYRQVLII 340
Cdd:pfam07690 193 AWKALLRDPVLWLLLA--LLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLL 270
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 327549383  341 NTVLIGATISLFATVSTSTPLALIVLLGLTQGVFNSLQFSSMNSMAYADISSADTSMASTLASSLQQMSMSFG 413
Cdd:pfam07690 271 ALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
 
Name Accession Description Interval E-value
PRK10504 PRK10504
putative transporter; Provisional
10-445 2.25e-90

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 283.16  E-value: 2.25e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  10 DNSAIKRYLPWVVATALFMEQLDSTIINTAVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAV 89
Cdd:PRK10504   3 DLPDSVRWQLWIVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAI 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  90 AIFTFASVLCGLSQNVPMLVAARILQGMGAAMMMPVGRLTIVRTFPKFELLRAMNFVIIPALIGPLLGPTIGGLIVHVTS 169
Cdd:PRK10504  83 VLFTLGSLFCALSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYAS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 170 WRVIFFVNVPVGLAAQWLIHKHMPDYHGDaPRPLDVVGMVLFGTGTALLSWLLEIFGEHKLDATSTGVLLLLALSLLATY 249
Cdd:PRK10504 163 WHWIFLINIPVGIIGAIATLMLMPNYTMQ-TRRFDLSGFLLLAVGMATLTLALDGSKGLGLSPLAIAGLVAVGVVALLLY 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 250 VWHAGRIASPLLRLALFRVRTFRVSVVGGFVTRLGLGGLPFLLPLLYQLGLGLPAWQSGLLMMPAAAGAMGMKLMAARLL 329
Cdd:PRK10504 242 LLHARNNNRALFSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVV 321
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 330 KRFGYRQVLIINTVLIGATISLFATVSTSTPLALIVLLGLTQGVFNSLQFSSMNSMAYADISSADTSMASTLASSLQQMS 409
Cdd:PRK10504 322 NRFGYRRVLVATTLGLALVSLLFMLVALLGWYYLLPFVLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQLS 401
                        410       420       430
                 ....*....|....*....|....*....|....*.
gi 327549383 410 MSFGLAcgslVTGWYLGDLPESNRLAVTSALHHAFL 445
Cdd:PRK10504 402 MSIGVT----IAGLLLGLFGQQHVSVDSGATHTVFM 433
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
22-462 7.12e-75

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 240.17  E-value: 7.12e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  22 VATALFMEQLDSTIINTAVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLCGL 101
Cdd:cd17503    1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 102 SQNVPMLVAARILQGMGAAMMMPVGRLTIVRTFPKFELLRAMNFVIIPALIGPLLGPTIGGLIVHVTSWRVIFFVNVPVG 181
Cdd:cd17503   81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 182 LAAQWLIhkhmpdyhgdaprpldvvgmvlfgtgtallswlleifgehkldatstgvllllalsllatyvwhagriasPLL 261
Cdd:cd17503  161 ILALLLA----------------------------------------------------------------------PLL 170
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 262 RLALFRVRTFRVSVVGGFVTRLGLGGLPFLLPLLYQLGLGLPAWQSGLLMMPAAAGAMGMKLMAARLLKRFGYRQVLIIN 341
Cdd:cd17503  171 DLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAG 250
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 342 TVLIGATISLFATVSTSTPLALIVLLGLTQGVFNSLQFSSMNSMAYADISSADTSMASTLASSLQQMSMSFGLACGSLV- 420
Cdd:cd17503  251 LLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLl 330
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|
gi 327549383 421 ---TGWYLGDLPE-----SNRLAVTSALHHAFLTLGVMTVLSSLSFRTLK 462
Cdd:cd17503  331 tnrTQFHHSRLSEllaqqVQKQALIIAFNDAFLVSAILLLVGLLLALFLR 380
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
25-415 7.56e-51

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 179.88  E-value: 7.56e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383   25 ALFMEQLDSTIINTAVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLCGLSQN 104
Cdd:TIGR00711  10 GTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPN 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  105 VPMLVAARILQGMGAAMMMPVGRLTIVRTFPKFELLRAMNFVIIPALIGPLLGPTIGGLIVHVTSWRVIFFVNVPVGLAA 184
Cdd:TIGR00711  90 LELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIV 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  185 QWLIHKHMPDYHGDAPRPLDVVGMVLFGTGTALLSWLLEIFGEHK-LDATSTGVLLLLALSLLATYVWHAGRIASPLLRL 263
Cdd:TIGR00711 170 VVVAFFILPRDKPAASENFDFLGLLLLSVGLGSLLYGLSEGPERGwFDSNEILILSITGLVAIIAFVVWELTDDNPLVDL 249
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  264 ALFRVRTFRVSVVGGFVTRLGLGGLPFLLPLLYQLGLGLPAWQSGLLMMPAAAGAMGMKLMAARLLKRFGYRQVLIINTV 343
Cdd:TIGR00711 250 RLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLVTIGLI 329
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 327549383  344 LIGATISLFA-TVSTSTPLALIVLLGLTQGVFNSLQFSSMNSMAYADISSADTSMASTLASSLQQMSMSFGLA 415
Cdd:TIGR00711 330 LYAVGFYWRAfTFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGTA 402
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
22-456 4.57e-46

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 163.88  E-value: 4.57e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  22 VATALFMEQLDSTIINTAVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLCGL 101
Cdd:cd17321    1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 102 SQNVPMLVAARILQGMGAAMMMPVGRLTIVRTFPKFELLRAMNFVIIPALIGPLLGPTIGGLIVHVTSWRVIFFVNVPVG 181
Cdd:cd17321   81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 182 Laaqwlihkhmpdyhgdaprpldvvgmvlfgtgtallswlleifgehkldatstgvllllalsllatyvwhagriaspll 261
Cdd:cd17321  161 L------------------------------------------------------------------------------- 161
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 262 rLALFRVRTFRVSVVGGFVTRLGLGGLPFLLPLLYQLGLGLPAWQSGLLMMPAAAGAMGMKLMAARLLKRFGYRQVLIIN 341
Cdd:cd17321  162 -VALLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAG 240
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 342 TVLIGATISLFATVSTSTPLALIVLLGLTQGVFNSLQFSSMNSMAYADISSADTSMASTLASSLQQMSMSFGLA-CGSLV 420
Cdd:cd17321  241 LLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVAlLGALL 320
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....
gi 327549383 421 TGWYLGDLPES--------NRLAVTSALHHAFLTLGVMTVLSSL 456
Cdd:cd17321  321 TAGLSANLGDSgvaallsaAAAAFAAGFHLAFLVAAALALLAAL 364
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
9-411 5.17e-35

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 133.56  E-value: 5.17e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383   9 ADNSAIKRYLPWVVATALFMEQLDSTIINTAVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTA 88
Cdd:COG2814    2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  89 VAIFTFASVLCGLSQNVPMLVAARILQGMGAAMMMPVGRLTIVRTFPKFELLRAMNFVIIPALIGPLLGPTIGGLIVHVT 168
Cdd:COG2814   82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 169 SWRVIFFVNVPVGLAAQWLIHKHMPDYHGDAPRPLDVVgmvlfgtgtallswlleifgehkldatstgvllllalsllat 248
Cdd:COG2814  162 GWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGS------------------------------------------ 199
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 249 yvwhagriaspllRLALFRVRTFRVSVVGGFVTRLGLGGLPFLLPLLYQLGLGLPAWQSGLLMMPAAAGAMGMKLMAARL 328
Cdd:COG2814  200 -------------LRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRL 266
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 329 LKRFGYRQVLIINTVLIGATISLFATVSTstpLALIVLLGLTQGVFNSLQFSSMNSMAYADISSADTSMASTLASSLQQM 408
Cdd:COG2814  267 ADRFGRRRLLLIGLLLLALGLLLLALAGS---LWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343

                 ...
gi 327549383 409 SMS 411
Cdd:COG2814  344 GGP 346
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
6-280 4.93e-32

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 124.15  E-value: 4.93e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383   6 SVPADNSAIKRYLPWVVATALFMEQLDSTIINTAVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVF 85
Cdd:COG0477    3 STDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  86 STAVAIFTFASVLCGLSQNVPMLVAARILQGMGAAMMMPVGRLTIVRTFPKFELLRAMNFVIIPALIGPLLGPTIGGLIV 165
Cdd:COG0477   83 LIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLV 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 166 HVTSWRVIFFVNVPVGLAAQWLIHKHMPDYHGDAPRPLDVVGMVLFGTGTALLSWLLEIFGEHKLDATSTGVLLLLALSL 245
Cdd:COG0477  163 AALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLL 242
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 327549383 246 LATYVWHAGRIASPLLRLALFRVRTFRVSVVGGFV 280
Cdd:COG0477  243 LALLLLALLLLLALLLLAALLLLLLLLLLLALLLA 277
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
22-415 2.22e-28

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 114.97  E-value: 2.22e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  22 VATALFMEQLDSTIINTAVPSMAISLGvtPLSLKA-VVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLCG 100
Cdd:cd17502    1 LMLALFLAALDQTIVATALPTIVAEFG--GLSLVSwVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCG 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 101 LSQNVPMLVAARILQGMGAAMMMPVGRLTIVRTFPKFEllRAMNFVIIPAL--IGPLLGPTIGGLIVHVTSWRVIFFVNV 178
Cdd:cd17502   79 LAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRE--RGKYQGYIGAVfgIASVAGPLIGGAFTDHLSWRWCFYINL 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 179 PVGLaaqwlihkhmpdyhgdaprpldvvgmvlfgtgtallswlleifgehkldatstgvllllalsllatyvwhagrias 258
Cdd:cd17502  157 PIGG---------------------------------------------------------------------------- 160
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 259 pllrLALFRVRTFRVSVVGGFVTRLGLGGLPFLLPLLYQLGLGLPAWQSGLLMMPAAAGAMGMKLMAARLLKRFG-YRQV 337
Cdd:cd17502  161 ----LALALLRTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGrYKPL 236
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 327549383 338 LIINTVLIGATISLFATVSTSTPLALIVLLGLTQGVFNSLQFSSMNSMAYADISSADTSMASTLASSLQQMSMSFGLA 415
Cdd:cd17502  237 IVIGTILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVA 314
MFS_1 pfam07690
Major Facilitator Superfamily;
22-413 2.05e-21

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 95.18  E-value: 2.05e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383   22 VATALFMEQLDSTIINTAVPS-MAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLCG 100
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  101 LSQNVPMLVAARILQGMGAAMMMPVGRLTIVRTFPKFELLRAMNFVIIPALIGPLLGPTIGGLIVHVTSWRVIFFVNVPV 180
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  181 GLAAqwlihkhmpdyhgdaprpldvvgmvlfgtgtALLSWLLEIFGEHKLDATstgvllllalsllatyvWHAGRIASPL 260
Cdd:pfam07690 161 SLLA-------------------------------AVLLLLPRPPPESKRPKP-----------------AEEARLSLIV 192
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  261 LRLALFRVRTFRVSVVggFVTRLGLGGLPFLLPLLYQLGLGLPAWQSGLLMMPAAAGAMGMKLMAARLLKRFGYRQVLII 340
Cdd:pfam07690 193 AWKALLRDPVLWLLLA--LLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLL 270
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 327549383  341 NTVLIGATISLFATVSTSTPLALIVLLGLTQGVFNSLQFSSMNSMAYADISSADTSMASTLASSLQQMSMSFG 413
Cdd:pfam07690 271 ALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
20-193 2.51e-21

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 95.33  E-value: 2.51e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  20 WVVATALFMEQLDSTIINTAVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLC 99
Cdd:cd17474    2 YAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLC 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 100 GLSQNVPMLVAARILQGMGAAMMMPVGRLTIVRTFPKFELLRAMNFVIIPALIGPLLGPTIGGLIVHVtSWRVIFF---V 176
Cdd:cd17474   82 GLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI-SWRYPFFllaA 160
                        170
                 ....*....|....*..
gi 327549383 177 NVPVGLAAQWLIHKHMP 193
Cdd:cd17474  161 LIPVAFLAILFLLPEPK 177
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
20-184 4.03e-21

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 94.55  E-value: 4.03e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  20 WVVATALFMEQLDSTIINTAVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLC 99
Cdd:COG2271   13 ALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLF 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 100 GLSQNVPMLVAARILQGMGAAMMMPVGRLTIVRTFPKFELLRAMNFVIIPALIGPLLGPTIGGLIVHVTSWRVIFFVNVP 179
Cdd:COG2271   93 GFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGL 172

                 ....*
gi 327549383 180 VGLAA 184
Cdd:COG2271  173 PGLLL 177
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
34-176 1.54e-20

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 93.02  E-value: 1.54e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  34 TIINTAVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLCGLSQNVPMLVAARI 113
Cdd:cd17320   16 DMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARF 95
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 327549383 114 LQGMGAAMMMPVGRLTIVRTFPKFELLRAMNFVIIPALIGPLLGPTIGGLIVHVTSWRVIFFV 176
Cdd:cd17320   96 LQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVF 158
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
22-423 1.73e-20

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 92.64  E-value: 1.73e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  22 VATALFMEQLDSTIINTAVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLCGL 101
Cdd:cd17325    1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 102 SQNVPMLVAARILQGMGAAMMMPVGRLTIVRTFPKFELLRAMNFVIIPALIGPLLGPTIGGLIVHVTSWRVIFFVNVPVG 181
Cdd:cd17325   81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 182 LAAQWLIHKHMPDYHGDAPRPLDVVGMVlfgtgtallswlleifgehkldatstgvllllalsllatyvwhagriasPLL 261
Cdd:cd17325  161 LLALVLALLLLPEPRPPPNKRAVSAARL-------------------------------------------------RSG 191
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 262 RLALFRVRTFRVSVVGGFVTRLGLGGLPFLLPLLYQLGLGLPAWQSGLLMMPAAAGAMGMKLMAARLLKRFGYRQVLIIN 341
Cdd:cd17325  192 LRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIG 271
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 342 TVLIGATISLFATVSTSTPLALIVLLGltqGVFNSLQFSSMNSMAyADISSADTSMAstlASSLQQMSMSFGLACGSLVT 421
Cdd:cd17325  272 LLLSAVALLLLPLATSFWLLLLLLALL---GLGLGLVFPATLALL-ADIVPPEGRGT---AMGLFNTAFSLGMVLGPLLG 344

                 ..
gi 327549383 422 GW 423
Cdd:cd17325  345 GF 346
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
22-457 2.39e-20

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 92.26  E-value: 2.39e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  22 VATALFMEQLDSTIINTAVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLCGL 101
Cdd:cd17504    1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 102 SQNVPMLVAARILQGMGAAmMMPVGRLTIVRTFPKFELLRAMNFVIIPALIGPLLGPTIGGLIVHVTSWRVIFFVNVPVG 181
Cdd:cd17504   81 APNLPVLIAGRALQGIGGA-VFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 182 LAAQwlihkhmpdyhgdaprpldvvgmvlfgtgtallswlleifgehkldatstgvllllalsllatyvwhagrIASPLL 261
Cdd:cd17504  160 VLLA----------------------------------------------------------------------ALVPLI 169
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 262 RLALFRVRT----FRVSVVGGFVTRLGLGGLPFLLPLLYQLGLGLPAWQSGLLMMPAAAGAMGMKLMAARLLKRFGYRQV 337
Cdd:cd17504  170 DLRLLRRRNvllaNITALLAGFGMFMVFQLLPQLLQLPTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRV 249
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 338 LIINTVLIGATISLFATVSTStpLALIVLLGLTQGVFNSLQFSSMNSMAYADISSADTSMASTLASSLQQMSMSFGLA-C 416
Cdd:cd17504  250 LLIGLVISAVGLLLLALLHSS--LWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAiA 327
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 327549383 417 GSLVTGWYLGDLPESnrLAVTSALHHAFLTLGVMTVLSSLS 457
Cdd:cd17504  328 GAILTTYTVSITSGG--VPTEGAYVLAFLIGAALALAALLL 366
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
39-188 1.95e-17

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 83.81  E-value: 1.95e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  39 AVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLCGLSQNVPMLVAARILQGM- 117
Cdd:PRK11102  13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLa 92
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 327549383 118 GAAMMMPVGRLtiVR-TFPKFELLRAMNFVIIPALIGPLLGPTIGGLIVHVTSWRVIFFVNVPVGLAAQWLI 188
Cdd:PRK11102  93 AAAASVVINAL--MRdMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALV 162
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
39-196 5.65e-17

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 82.43  E-value: 5.65e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383   39 AVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLCGLSQNVPMLVAARILQGMG 118
Cdd:TIGR00710  27 AFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFG 106
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 327549383  119 AAMMMPVGRLTIVRTFPKFELLRAMNFVIIPALIGPLLGPTIGGLIVHVTSWRVIFFVNVPVGLAAQWLIHKHMPDYH 196
Cdd:TIGR00710 107 ASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILPETL 184
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
31-176 1.01e-16

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 81.46  E-value: 1.01e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  31 LDSTIINTAVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLCGLSQNVPMLVA 110
Cdd:cd17319   17 LDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYV 96
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 327549383 111 ARILQGMGAAMMMPVGRLTIVRTFPKFELLRAMNFVIIPALIGPLLGPTIGGLIVHVTSWRVIFFV 176
Cdd:cd17319   97 LRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFII 162
2_A_01_02 TIGR00880
Multidrug resistance protein;
58-194 1.29e-16

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 76.53  E-value: 1.29e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383   58 VTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLCGLSQNVPMLVAARILQGMGAAMMMPVGRLTIVRTFPKF 137
Cdd:TIGR00880   4 LAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPE 83
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 327549383  138 ELLRAMNFVIIPALIGPLLGPTIGGLIVHVTSWRVIFFVNVPVGLAAQWLIHKHMPD 194
Cdd:TIGR00880  84 ERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPE 140
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
20-178 2.23e-16

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 80.70  E-value: 2.23e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  20 WVVATALFMEQLDSTIINTAVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLC 99
Cdd:cd17323    2 FIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGC 81
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 327549383 100 GLSQNVPMLVAARILQGMGAAMMMPVGRLTIVRTFPKFELLRAMNFVIIPALIGPLLGPTIGGLIVHVTSWRVIFFVNV 178
Cdd:cd17323   82 ALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLA 160
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
20-424 2.73e-16

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 80.29  E-value: 2.73e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  20 WVVATALFMEQLDSTIINTAVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLC 99
Cdd:cd17324    2 LALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 100 GLSQNVPMLVAARILQGMGAAMMMPVGRLTIVRTFPKFELLRAMNFVIIPALIGPLLGPTIGGLIVHVTSWRVIFFVNVP 179
Cdd:cd17324   82 ALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAV 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 180 VGLAAQWLIHKHMPDYHGDAPRPLDVVGMVLFGTGTALLSWLLeifgehkldatSTGVLLLLALSLLATYvwhagriasp 259
Cdd:cd17324  162 LALLAALLLWRLLPSLPPKKPGSLGLLSSLLLLLRNPRLRLAY-----------LITFLLFGGFFALYTY---------- 220
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 260 llrLALFRVRTFRVSVvggfvtrlglgglpfllpllyqlglglpAWQSGLLMMPAAAGAMGMKLmAARLLKRFGYRQVLI 339
Cdd:cd17324  221 ---LAPFLTDVPGFSS----------------------------SAIIGLLLLFGVAGVVGSPL-AGRLADRGGRRALLI 268
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 340 INTVLIGATISLFATVSTSTP-LALIVLLGLTQGVFNslqfsSMNSMAYADISSADTSMASTLASSLQQMSMSFGLACGS 418
Cdd:cd17324  269 ALLLLAAALLLLTLLGPSPLLlLVGLVLWGLGFFAAH-----SALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGG 343

                 ....*.
gi 327549383 419 LVTGWY 424
Cdd:cd17324  344 LVLDHG 349
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
21-193 3.31e-15

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 76.92  E-value: 3.31e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  21 VVATALFMEQLDSTIINTAVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLCG 100
Cdd:cd17476    2 TISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 101 LSQNVPMLVAARILQGMGAAMMMPVGRLTIVRTFPKfELLRAMNFVIIPAL--IGPLLGPTIGGLIVHVTSWRVIFF--- 175
Cdd:cd17476   82 FSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPP-GPRKNIVFSLFGATapLGFALGGVFGGLFAQLAWWPWIFWfla 160
                        170
                 ....*....|....*....
gi 327549383 176 -VNVPVGLAAQWLIHKHMP 193
Cdd:cd17476  161 iLAAIVAVAAIFWTSPSFI 179
PRK14995 PRK14995
SmvA family efflux MFS transporter;
31-402 7.86e-15

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 76.69  E-value: 7.86e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  31 LDSTIINTAVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLCGLSQNVPMLVA 110
Cdd:PRK14995  20 IDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIA 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 111 ARILQGMGAAMMMPVGRLTIVRTFPKfELLRAMNFVIIPAL--IGPLLGPTIGGLIVHVTSWRVIFFVNVPVGLAAQWLI 188
Cdd:PRK14995 100 TRALLAIGAAMIVPATLAGIRATFTE-EKQRNMALGVWAAVgsGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMGLT 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 189 HKHMPDYHGDAPRPLDVVGMVLFGTGTALLSWLLEIFGEHKLDATSTGVLLLLALSLLATYVWHAGRIASPLLRLALFRV 268
Cdd:PRK14995 179 ARYVPRQAGRRDQPLNLGHALMLIVAILLLVYSAKTALKGFLSLWVTSLTLLTGALLLGLFIRTQLAASRPMIDMRLFTH 258
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 269 RTFRVSVVGGFVTRLGLGGLPFLLPLLYQLGLGLPAWQSGLLMMPAAAGAMGMKLMAARLLKRFGYRQVliintvligat 348
Cdd:PRK14995 259 RIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVSRLGLRLV----------- 327
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 327549383 349 islfatVSTSTPLALIVLLGLTQGVFNSLQFSSMNSMAYADISSADTSMASTLA 402
Cdd:PRK14995 328 ------ATGGMALSALSFYGLAMTDFSTQQWQAWGLMALLGFSAASALLASTSA 375
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
25-194 2.11e-14

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 74.70  E-value: 2.11e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383   25 ALFMEQLDSTIINTAVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLCGLSQN 104
Cdd:TIGR00895  25 IMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATN 104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  105 VPMLVAARILQGMGAAMMMPVGRLTIVRTFPKFELLRAMNFVIIPALIGPLLGPTIGGLIVHVTSWRVIFFVNVPVGLAA 184
Cdd:TIGR00895 105 VTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLL 184
                         170
                  ....*....|
gi 327549383  185 QWLIHKHMPD 194
Cdd:TIGR00895 185 LLLLMRFLPE 194
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
57-377 1.51e-12

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 69.58  E-value: 1.51e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  57 VVTSYILSLAVCIPVSGWMADRFGtRRVFSTAVAIFTFA-SVLCGLSQNVPMLVAARILQGMGAAM--MMPVGRLTIVRT 133
Cdd:cd06179   37 ISTAWSLAQAVLGPIVGRLSDLFG-RRWFFIGGNLLGVVgSIVAGTAKSVNMLIGGQALIGIGAGTqgLGAAVASELVPN 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 134 FPKFELLRAMNFViipALIGPLLGPTIGGLIV--HVTSWRVIFFVNVPVGLAAQ--WLIHKHMPDYH-------GDAPRP 202
Cdd:cd06179  116 KYRGLVQGVVNLV---ASPGSALGPLIAGALVeaNAAGWRWIFYINAIFNALALilLFFFYHPPPRPqlhgsstRQKLKR 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 203 LDVVGMVLFGTGTAL----LSWLLEIFGEHKLDATSTGVLLLLALSLLATYVWHaGRIASPLLRLALFRVRTFRVSVVGG 278
Cdd:cd06179  193 LDWVGLFLLIAGLVLfllgLSWGGNPYPWSSAHVIAPLVIGGVLLIAFGLYEWK-GTKDGLLPPRLLFRGRNFALILIVA 271
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 279 FVTRLGLGGLPFLLPLLYQLGLGLPAWQSGLLMMPAAAGAMGMKLMAARLLKRFGY-RQVLIINTVLIGATISLFATV-- 355
Cdd:cd06179  272 FVEGMIFYSLNIFWPQQISLLFTTDPLKAGLYQLPFGLGTLFGAILAGLLLTKIKHiKWQLVAGFVLFTAFLALLALItp 351
                        330       340
                 ....*....|....*....|...
gi 327549383 356 -STSTPLALIVLLGLTQGVFNSL 377
Cdd:cd06179  352 dNKALAIAFSVLAGIGIGGPLVL 374
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
73-203 1.85e-12

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 68.81  E-value: 1.85e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  73 GWMADRFGTRRVFSTAVAIFTFASVLCGLSQNVPMLVAARILQGMGAAMMMPVGRLTIVRTFPKFELLRAMNFVIIPALI 152
Cdd:PRK15402  69 GPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYAAIQESFEEADAIKITALMANVALL 148
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 327549383 153 GPLLGPTIGGLIVHVTSWRVIFFVNVPVGLAAQWLIHKHMPDYHGDAPRPL 203
Cdd:PRK15402 149 APLLGPLVGAALIHVLPWRGMFVLFAALAALSFFGLWRAMPETAGRVGEKL 199
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
20-194 1.79e-11

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 65.67  E-value: 1.79e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  20 WVVATALFMEQLDSTIINTAVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLC 99
Cdd:COG2223    8 LLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLL 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 100 GLSQNVPMLVAARILQGMGAAMMMPVGRLTIVRTFPKFELLRAMNFVIIPALIGPLLGPTIGGLIVHVTSWRVIFFVNVP 179
Cdd:COG2223   88 ALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGI 167
                        170
                 ....*....|....*
gi 327549383 180 VGLAAQWLIHKHMPD 194
Cdd:COG2223  168 LLLVVAVLAWLFLRD 182
emrD PRK11652
multidrug transporter EmrD;
30-193 5.33e-11

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 64.16  E-value: 5.33e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  30 QLDSTIINTAVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLCGLSQNVPMLV 109
Cdd:PRK11652  21 QMAQTIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLI 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 110 AARILQGMGAAmmmpVGRLtIVRTFPK-----FELLRAMNFVIIPALIGPLLGPTIGGLIVHVTSWRVIFFVNVPVGLAA 184
Cdd:PRK11652 101 AASAIQGLGTG----VGGV-MARTLPRdlyegTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFLLLLGAGV 175

                 ....*....
gi 327549383 185 QWLIHKHMP 193
Cdd:PRK11652 176 TFSMARWMP 184
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
21-176 9.26e-11

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 62.99  E-value: 9.26e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  21 VVATALFMEQLDSTIINTAVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLCG 100
Cdd:cd17365    3 LCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTA 82
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 327549383 101 LSQNVPMLVAARILQGMGAAMMMPVGRLTIVRTFPKFELLRAMNFVIIPALIGPLLGPTIGGLIVHVTSWRVIFFV 176
Cdd:cd17365   83 FAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLL 158
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
31-218 5.69e-10

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 60.90  E-value: 5.69e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  31 LDSTIINTAVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLCGLSQNVPMLVA 110
Cdd:cd06174   10 LARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 111 ARILQGMGAAMMMPVGRLTIVRTFPKFELLRAMNFVIIPALIGPLLGPTIGGLIV--HVTSWRVIFFVNVPVGLAAQWLI 188
Cdd:cd06174   90 GRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFLIAAALALLAAILL 169
                        170       180       190
                 ....*....|....*....|....*....|
gi 327549383 189 HKHMPDYHGDAPRPLDVVGMVLFGTGTALL 218
Cdd:cd06174  170 LLVVPDPPESARAKNEEASSKSVLKLLKRV 199
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
25-187 9.91e-10

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 59.92  E-value: 9.91e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  25 ALFMEQLDSTIINTAVPSMA--ISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLCGLS 102
Cdd:cd17316    7 GWFFDAYDFFLIGFVAPVLAaeFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLL 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 103 QNVPMLVAARILQGMGAAMMMPVGRLTIVRTFPK----FELLRAMNFVIIPALIGPLLGPTIGGLIVHVTSWRVIFFVNV 178
Cdd:cd17316   87 PTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSkrrgFALGLLQSGWALGALLAALVASLLIPLLSGDWGWRILFLIGA 166

                 ....*....
gi 327549383 179 PVGLAAQWL 187
Cdd:cd17316  167 LPALLALLL 175
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
34-194 1.03e-09

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 59.89  E-value: 1.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  34 TIINTAVPSMA-ISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLCGLSQNVPMLVAAR 112
Cdd:cd17473   16 AAIAPALPAIAqHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASR 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 113 ILQGMGAAMMMPVGRLTIVRTFPKFELLRAMNFVIIPALIGPLLGPTIGGLIVHVtSWRVIFFV---NVPVGLAAQWLIH 189
Cdd:cd17473   96 ALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEI-GWRAPFLVyllALPVLILVLLFLP 174

                 ....*
gi 327549383 190 KHMPD 194
Cdd:cd17473  175 EPARK 179
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
20-184 1.04e-09

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 60.33  E-value: 1.04e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  20 WVVATALFMEQLDSTIINTAVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLC 99
Cdd:cd17328    2 AVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 100 GLSQNVPMLVAARILQGMGAAMMMPVGRLTIVRTFPKFELLRAMNFVIIPALIGPLLGPTIGGLIVHVT-SWRVIFFVNV 178
Cdd:cd17328   82 SFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTG 161

                 ....*.
gi 327549383 179 PVGLAA 184
Cdd:cd17328  162 VLGVLL 167
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
32-118 1.29e-09

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 59.89  E-value: 1.29e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  32 DSTIINTAVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLCGLSQNVPMLVAA 111
Cdd:cd17359   16 DTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIA 95

                 ....*..
gi 327549383 112 RILQGMG 118
Cdd:cd17359   96 RIIGGLA 102
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
35-176 3.61e-09

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 58.37  E-value: 3.61e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  35 IINTAVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLCGLSQNVPMLVAARIL 114
Cdd:cd17489   14 LLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLI 93
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 327549383 115 QGMGAAMMMPVGRLTIVRTFPKFELLRAMNFVIIPALIGPLLGPTIGGLIVHVTSWRVIFFV 176
Cdd:cd17489   94 HGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIV 155
PRK15403 PRK15403
multidrug efflux MFS transporter MdtM;
73-221 9.88e-09

multidrug efflux MFS transporter MdtM;


Pssm-ID: 237958 [Multi-domain]  Cd Length: 413  Bit Score: 57.14  E-value: 9.88e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  73 GWMADRFGTRRVFSTAVAIFTFASVLCGLSQNVPMLVAARILQGMGAAMMMPVGRLTIVRTFPKFELLRAMNFVIIPALI 152
Cdd:PRK15403  72 GPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLV 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 153 GPLLGPTIGGLIVHVTSWRVIFFVNVPVGLAAQWLIHKHMPDYHGDAPRPLDVVG------------MVLFGTGTALLSW 220
Cdd:PRK15403 152 APIIGPLSGAALMHFVHWKVLFAIIAVMGLIAFVGLLLAMPETVKRGAVPFSAKSvlrdfrnvfrnrLFLTGAATLSLSY 231

                 .
gi 327549383 221 L 221
Cdd:PRK15403 232 I 232
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
28-224 1.07e-08

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 56.89  E-value: 1.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  28 MEQLDSTIINTAVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLCGLSQNVPM 107
Cdd:PRK11551  26 LEGLDLQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPS 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 108 LVAARILQGMGAAMMMPVGRLTIVRTFPKFELLRAMNFVIIPALIGPLLGPTIGGLIVHVTSWRVIFFVN--VP---VGL 182
Cdd:PRK11551 106 LLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGgvGPlllVPL 185
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 327549383 183 AAQWLIHKHMPDYHGDAPRPLDVVGMVLFGTGTALLSWLLEI 224
Cdd:PRK11551 186 LMRWLPESRAFAQAAGAGKQRAPVLRALFGEGRATATLLLWI 227
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
23-176 2.19e-08

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 56.02  E-value: 2.19e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  23 ATALFMEQLDSTIINTAVPSMAISLGVTpLSLKAVVTS-----YILSLAVcipvSGWMADRFGTRRVFSTAVAIFTFASV 97
Cdd:cd17380    5 FLATCICYADRVNMPIAIVPMAKEFGWS-KTDQGLVLSsffwgYALTQVL----GGYLADRFGGKKVLLLAVALWSLATL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  98 LCGL--SQNVPMLVAARILQGMGAAMMMPVGRLTIVRTFPKFELLRAMNFVIIPALIGPLLGPTIGGLIVHVTSWRVIFF 175
Cdd:cd17380   80 LTPLlaYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFY 159

                 .
gi 327549383 176 V 176
Cdd:cd17380  160 F 160
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
20-453 5.86e-08

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 54.86  E-value: 5.86e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  20 WVVATALFMEQLDSTIINTAVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLC 99
Cdd:COG0738   11 IAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLF 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 100 GLSQNVPMLVAARILQGMGAAMMMPVGRLTIVRTFPKfelLRAMNFVIIPAL--IGPLLGPTIGGLIVHVtswrviffvn 177
Cdd:COG0738   91 ALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPE---TAASRLNLLHAFfsLGALLGPLLGGLLILL---------- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 178 vpvGLAAQWlihkHMPdyhgdaprpldVVGMVLFGTGTALLSWLLEIFGEHKLDATSTGVLLLLalsllatyvwhagria 257
Cdd:COG0738  158 ---GLSLSW----HLP-----------YLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASL---------------- 203
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 258 spllrLALFRVRTFRVSVVGGFVTRLGLGGLPFLLPLLYQLGLGLPAWQSGLLMMPAAAGAMGMKLMAARLLKRFGYRQV 337
Cdd:COG0738  204 -----KSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRL 278
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 338 LIINTVLigATISLFATVSTSTPLALIVLLGLTqGVFNSLQFSSMNSMAyadisSADTSMASTLASSLQQMSMSFGLACG 417
Cdd:COG0738  279 LRLSALL--AAVGLLLALLAPGPWLALIGLALV-GLGLSLMFPTIFSLA-----LDGLGKRTAAAVSAVLIMGIVGGAIG 350
                        410       420       430
                 ....*....|....*....|....*....|....*.
gi 327549383 418 SLVTGWylgdlpesnrLAVTSALHHAFLTLGVMTVL 453
Cdd:COG0738  351 PPLIGF----------LADAFGLRAAFLVPLVCYLL 376
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
38-175 1.36e-07

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 53.49  E-value: 1.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  38 TAVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLCGLSQNVPMLVAARILQGM 117
Cdd:PRK10473  24 VGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGI 103
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 327549383 118 GAAMMMPVGrLTIVR-TFPKFELLRAMNFVIIPALIGPLLGPTIGGLIVHVTSWRVIFF 175
Cdd:PRK10473 104 GAGCCYVVA-FAILRdTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFY 161
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
40-184 1.45e-06

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 50.30  E-value: 1.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  40 VPSMAISLGVTPLSLKAVVTSY-ILSLAVCIPVsGWMADRFGTRRVFSTAVAIFT-FASVLCGLSQNVPMLVAARILQGM 117
Cdd:cd17490   19 LSPYAESLGASLSMIGIILGAYgISQMLLRIPL-GILSDRIGKRKLFIIIGLLFTvLASLIMILFPSPWGLLIARFLSGI 97
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 327549383 118 GAAMMMpVGRLTIVRTFPKFELLRAMNFVIIPALIGPLLGPTIGGLIVHVTSWRVIFFVNVPVGLAA 184
Cdd:cd17490   98 AAATWV-SFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLG 163
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
20-194 1.62e-06

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 49.99  E-value: 1.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  20 WVVATALFMEQLDSTIINTAVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLC 99
Cdd:cd17371    2 WAAFLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLC 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 100 GLSQNVPMLVAARILQGMGAAMMMPVGRLTIVRTFPKFELLRAMNFVIIPALIGPLLGPTIGGLIVHV----TSWRVIFF 175
Cdd:cd17371   82 GFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLlppeIAWRVLFL 161
                        170
                 ....*....|....*....
gi 327549383 176 VNVPVGLAAqWLIHKHMPD 194
Cdd:cd17371  162 LGALPALLV-LFIRRFVKE 179
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
32-125 2.13e-06

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 49.58  E-value: 2.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  32 DSTIINTAVPSMAISLGVTPLS--LKAVVTSY-ILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLCGLSQNVPML 108
Cdd:cd17360   12 DTGVISGALLYIKDDLGEVVLStgWQELIVSStVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVL 91
                         90       100
                 ....*....|....*....|
gi 327549383 109 VAARILQGMG---AAMMMPV 125
Cdd:cd17360   92 IVGRVLVGLGvgiASMTVPL 111
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
33-382 4.36e-06

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 48.77  E-value: 4.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  33 STIINTAVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFST-----AVAIFTFASVLCGLSQNVPM 107
Cdd:cd06173   15 DWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILadllrALLAAVLALLALLGSLSLWL 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 108 LVAARILQGMGAAMMMPVGRLTIVRTFPKFELLRAMNFVIIPALIGPLLGPTIGGLIVHVTSWRVIFFVNVpvglaaqwl 187
Cdd:cd06173   95 LLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINA--------- 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 188 ihkhmpdyhgdaprpldvvgmVLFGTGTALLSWLLEIFGEHKLDATSTgvlLLLALSLLATYVWHAGRIASPLLRLALFr 267
Cdd:cd06173  166 ---------------------LSFLLSALLLLFIRRPPPAAPGESSSL---LLRDLREGLRYLRRSPLLRLLLLALALF- 220
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 268 vrtfrvSVVGGFVTrlglgglpFLLPLLYQLGLGLPAWQSGLLMMPAAAGAMGMKLMAARLLKRFGYRQVLIINTVLIGA 347
Cdd:cd06173  221 ------ALLGGALT--------VLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGL 286
                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 327549383 348 TISLFAtVSTSTPLALI--VLLGLTQGVFNSLQFSSM 382
Cdd:cd06173  287 ALLVLG-LSPSLWLLLAalFLLGLAGGLFNVPLNTLL 322
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
40-176 7.99e-06

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 47.95  E-value: 7.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  40 VPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLCGLSQNVPMLVAARILQGMGA 119
Cdd:COG2807   41 LPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGI 120
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 327549383 120 AMMMPVGRLTIVRTFPKfELLRAMNFVIIPALIGPLLGPTIGGLIVHVTSWRVIFFV 176
Cdd:COG2807  121 AVGNVLLPGLIKRWFPD-RVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAV 176
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
22-176 8.30e-06

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 47.96  E-value: 8.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  22 VATALFMEQLDSTIINTAVPSM---AISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVL 98
Cdd:cd17330    1 LFLVVFLDALGFGIVFPVLPFYvreFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  99 CGLSQNVPMLVAARILQGMGAAMMMPVGRLTIVRTFPKFellRAMNFVIIPAL--IGPLLGPTIGGLIVHVTSWRVIFFV 176
Cdd:cd17330   81 LGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEE---RAKAFGIISAAfgLGFILGPALGGFLSTPYGYALPFLV 157
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
73-119 9.71e-06

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 47.60  E-value: 9.71e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 327549383  73 GWMADRFGTRRVFSTAVAIFTFASVLCGLSQNVPMLVAARILQGMGA 119
Cdd:cd17472   53 GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGA 99
PRK03893 PRK03893
putative sialic acid transporter; Provisional
32-196 1.16e-05

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 47.77  E-value: 1.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  32 DSTIINTAVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLCGLSQNVPMLVAA 111
Cdd:PRK03893  35 DFVLITLVLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIA 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 112 RILQGMGAAMMMPVGRLTIVRTFPKFELLRAMNFVIIPALIGPLLGPTIGGLIVHVTSWRVIFFVN-VPVGLAaqWLIHK 190
Cdd:PRK03893 115 RLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWRALFFIGiLPIIFA--LWLRK 192

                 ....*.
gi 327549383 191 HMPDYH 196
Cdd:PRK03893 193 NLPEAE 198
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
57-126 1.29e-05

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 47.19  E-value: 1.29e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  57 VVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLCGLSQNVPMLVAARILQGMGAAMMMPVG 126
Cdd:cd17317   30 VQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVG 99
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
37-176 1.84e-05

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 46.99  E-value: 1.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383   37 NTAVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLCGLSQNVPMLVAARILQG 116
Cdd:TIGR00881  15 ALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNG 94
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 327549383  117 MGAAMMMPVGRLTIVRTFPKFELLRAMNFVIIPALIGPLLGPTIGGLIVHVT-SWRVIFFV 176
Cdd:TIGR00881  95 IFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELySWHWVFIV 155
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
18-176 2.40e-05

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 46.47  E-value: 2.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  18 LPWVVATALFMEQLDSTIINTAVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASV 97
Cdd:cd17327    7 LPLLCILYFLQYLDKSNISNAAVMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTL 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  98 LCGLSQNVPMLVAARILQGMGAAMMMPVGRLTIVRTFPKFELLRAMNFVIIPALIGPLLGPTIGGLIVHVT------SWR 171
Cdd:cd17327   87 LTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKILgvgglaGWR 166

                 ....*
gi 327549383 172 VIFFV 176
Cdd:cd17327  167 WLFII 171
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
20-118 4.88e-05

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 45.35  E-value: 4.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  20 WVVA-TALFMEQLDSTIINTAVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVS-----GWMADRFGTRRVFSTAVAIFT 93
Cdd:cd17364    1 IIIAgMGFFTDAYDLFSISLVTKILGRLYYGGKGSLPSGVSGLVNAAALVGTIIgqlffGFLGDRFGRKRVYGVELIIMI 80
                         90       100       110
                 ....*....|....*....|....*....|.
gi 327549383  94 FASVLCGLSQN------VPMLVAARILQGMG 118
Cdd:cd17364   81 IGTILSALSPGstplgvMGWLIFFRFLLGIG 111
PRK12307 PRK12307
MFS transporter;
47-194 5.14e-05

MFS transporter;


Pssm-ID: 237051 [Multi-domain]  Cd Length: 426  Bit Score: 45.69  E-value: 5.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  47 LGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLCGLSQNVPMLVAARILQGMGAAMMMPVG 126
Cdd:PRK12307  48 LGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMGMAGEYACA 127
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 327549383 127 RLTIVRTFPKFELLRAMNFVIIPALIGPLLGPTIGGLIVHVTSWRVIFFVNVPVGLAAQWlIHKHMPD 194
Cdd:PRK12307 128 STYAVESWPKHLKSKASAFLVSGFGIGNIIAAYFMPSFAEAYGWRAAFFVGLLPVLLVIY-IRARAPE 194
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
22-123 5.20e-05

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 45.24  E-value: 5.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  22 VATALFMEQLDSTIINTAVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLCGL 101
Cdd:cd17477    1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80
                         90       100
                 ....*....|....*....|..
gi 327549383 102 SQNVPMLVAARILQGMGAAMMM 123
Cdd:cd17477   81 TDSPWVWFLLRFVMGIGLAGLF 102
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
36-183 9.07e-05

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 44.57  E-value: 9.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  36 INTAVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLCGLSQNVPMLVAARILQ 115
Cdd:cd17312   22 FSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLN 101
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 327549383 116 GMGAAMMMPVGRLTIVRTFPKFELLRAMNFVIIPALIGPLLGPTIGGLIVHVTSWRVIFFVNVPVGLA 183
Cdd:cd17312  102 GLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLV 169
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
41-165 1.10e-04

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 44.53  E-value: 1.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  41 PSMAISLgVTPLSLKAVVTSYILSLAVCI-----PVSGWMADRFGTRRVFSTAVAIFTFASVLCGLSQNVPMLVAARILQ 115
Cdd:cd17329   20 PFMAIYL-HQQLGLSASIVGLVLALSAVAgivasLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLT 98
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 327549383 116 GMGAAMMMPVGRLTIVRTFPKFELLRAMNFVIIPALIGPLLGPTIGGLIV 165
Cdd:cd17329   99 GFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLL 148
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
59-220 1.27e-04

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 44.66  E-value: 1.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383   59 TSYILSLAVCIPVSGWMADRFGtRRVFSTAVAIFTFASVLCGLSQN-VPMLVAARILQGMGA----AMMMPVGRLTIVRT 133
Cdd:pfam06609  85 TLWTMGQAVSILMMGRLTDRFG-RRPFVIATHIIGLVGAIVGCTANkFNTLLAAMTLLGVAAgpagASPLFIGELMSNKT 163
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  134 fpKFellRAMNFVIIPALIGPLLGPTIGGLIVHVTSWRVIFFVNVPVGLAAQWLI--HKHMPDY---HGDAPR------P 202
Cdd:pfam06609 164 --KF---LGLLIVSAPTIAMNGAGPYFGQRLAIQGNWRWIFYIYIIMSAIAVLLIiiWYHPPSFaqlHGKKARkrdelaK 238
                         170       180
                  ....*....|....*....|..
gi 327549383  203 LDVVGMVLFGTGTAL----LSW 220
Cdd:pfam06609 239 LDWIGIFLVIAGTSLfllgVSW 260
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
36-176 1.29e-04

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 44.15  E-value: 1.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  36 INTAVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLCGLSQNVPMLVAARILQ 115
Cdd:cd17475   15 IPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLV 94
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 327549383 116 GMGAAMMMPVGRLTIVRTFPKFELLRAMNFVIIPALIGPLLGPTIGGLIVHVTSWRVIFFV 176
Cdd:cd17475   95 GAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVV 155
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
61-176 1.66e-04

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 43.76  E-value: 1.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  61 YILSLavcIPvSGWMADRFGTRRVFSTAVAIftfASVLCGL-----SQNVPMLVAARILQGMGAAMMMPVGRLTIVRTFP 135
Cdd:cd17318   69 YILTQ---IP-GGYLAEKYGAKRVLGYSILI---TALLTLLtplaaRGGYGALIVLRILQGLAQGVTFPAMHALWAKWAP 141
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 327549383 136 KFELLRAMNFVIIPALIGPLLGPTIGGLIVHVTSWRVIFFV 176
Cdd:cd17318  142 PLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYI 182
PRK10091 PRK10091
MFS transport protein AraJ; Provisional
41-197 3.64e-04

MFS transport protein AraJ; Provisional


Pssm-ID: 182234 [Multi-domain]  Cd Length: 382  Bit Score: 42.77  E-value: 3.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  41 PSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLCGLSQNVPMLVAARILQGMGAA 120
Cdd:PRK10091  27 TELAHDVGISIPAAGHMISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVIGNAMFTLSSSYLMLAIGRLVSGFPHG 106
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 327549383 121 MMMPVGRLTIVRTFPKFELLRAMNFVIIPALIGPLLGPTIGGLIVHVTSWRVIFFVNVPVGLAAQWLIHKHMPDYHG 197
Cdd:PRK10091 107 AFFGVGAIVLSKIIKPGKVTAAVAGMVSGMTVANLLGIPLGTYLSQEFSWRYTFLLIAVFNIAVLASIYFWVPDIRD 183
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
21-119 4.96e-04

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 42.33  E-value: 4.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383   21 VVATALFMEQLDSTIINTAVPSMAISLGVTPLSLKA--------VVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIF 92
Cdd:TIGR00879  32 IAAIGGLMFGYDTGVIGGALALPAFEFKFTSANSDSyssslwglVVSIFLVGGFIGALFAGWLSDRFGRKKSLLIIALLF 111
                          90       100       110
                  ....*....|....*....|....*....|
gi 327549383   93 TFASVLCGLS---QNVPMLVAARILQGMGA 119
Cdd:TIGR00879 112 VIGAILMGLAafaLSVEMLIVGRVLLGIGV 141
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
47-125 7.23e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 41.81  E-value: 7.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  47 LGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLCGLSQ--NVPMLVAARILQGMGAAMMMP 124
Cdd:COG2211  259 LGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILV 338

                 .
gi 327549383 125 V 125
Cdd:COG2211  339 L 339
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
306-426 9.07e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 41.43  E-value: 9.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 306 QSGLLMMPAAAGAMGMKLMAARLLKRFGYRQVLIINTVLIGATISLFATVSTSTPLALIVLLGLTqGVFNSLQFSSMNSM 385
Cdd:COG2211  265 LVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALA-GIGLGAILVLPWAM 343
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 327549383 386 aYADISSADTSMAST----LASSLQQMSMSFGLACGSLVTGWYLG 426
Cdd:COG2211  344 -LADVVDYDEWKTGRrregLYFGIFTFAIKLGQALAGALAGLLLA 387
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
20-135 1.33e-03

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 40.97  E-value: 1.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  20 WVVATALFMEQLDSTIINTAVPSMAIS-LGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVF-----STAVAIFT 93
Cdd:cd17369  231 LLAIGLRLAENVLFYLFTTFALSYATQtLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYlagalLAALFAFP 310
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 327549383  94 FASVLcGLSQNVPMLVAARILQGMGAAMMMPVGRLTIVRTFP 135
Cdd:cd17369  311 FFWLL-DTGSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFP 351
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
6-169 1.49e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 40.63  E-value: 1.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383   6 SVPADNSAIKRYLPWVVATALFMEQLDSTIINTAVPSMAISLGVTPLSLKAVVTSYILSLA-VCIPVSG----WMADRFG 80
Cdd:cd17473  182 SAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIAsLAGAIGAllfgRLKRRLG 261
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  81 TRRVFSTAVAIFTFASVLCGLSQNVPMLVAARILQGMGAAMMMPVGRLTIVRTFPKFELLRAMNFVIIPALIGPLLGPTI 160
Cdd:cd17473  262 KRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLV 341

                 ....*....
gi 327549383 161 GGLIVHVTS 169
Cdd:cd17473  342 LGPLVNLTG 350
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
35-118 1.77e-03

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 40.64  E-value: 1.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  35 IINTAVPSMAISLGV--TPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLCGLSQNVPMLVAAR 112
Cdd:cd17315   15 VINGALLYIAKDLGFglSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGR 94

                 ....*.
gi 327549383 113 ILQGMG 118
Cdd:cd17315   95 FLLGLG 100
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
57-176 2.24e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 40.33  E-value: 2.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  57 VVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLCGLSQNVPMLVAARILQGM-----GAAMMMpvgrltIV 131
Cdd:cd17391   41 AFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVfsgyvPNATAL------IA 114
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 327549383 132 RTFPKFELLRAMNFVIIPALIGPLLGPTIGGLIVHVTSWRVIFFV 176
Cdd:cd17391  115 SQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFI 159
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
56-176 4.66e-03

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 39.16  E-value: 4.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  56 AVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLCGLSQNVPMLVAARILQGMGAAmMMPVGRLTIVRTFP 135
Cdd:cd17388   42 VLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGITGA-TGAVAAAYIADVTP 120
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 327549383 136 KFEllRAMNFVIIPAL--IGPLLGPTIGGLIVHVtSWRVIFFV 176
Cdd:cd17388  121 PEQ--RARNFGLLGAAfgLGFIAGPALGGLLGEI-SPRAPFLV 160
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
304-430 4.88e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 39.13  E-value: 4.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 304 AWQSGLLMMPAAAGAMGMKLMAARLLKRFGYRQVLIINTVLIGATISLFATVStSTPLALIVLLGLtqGVFNSLQFSSMN 383
Cdd:cd17329   34 ASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAH-SPWLFAIALVLT--GFGGGLFEPASE 110
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 327549383 384 SMayadISSADTSMASTLASSLQQMSMSFGLACGSLVTGWYLGDLPE 430
Cdd:cd17329  111 AM----IADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFR 153
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
19-163 5.15e-03

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 39.11  E-value: 5.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  19 PWVVATALFMEQLDSTIINT-AVPSMA-ISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRV-FSTAVAIFTFA 95
Cdd:cd17326    1 IYVMYLTMFLSSLQFSIVLTsIWPYLQkIDPTATASFFGWVVAAYSLGQLVFSPVFGYWSNKTSSVKEpLIVSILIAIVG 80
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 327549383  96 SVLCGLSQNVP------MLVaARILQGMGAAMMMPVGRLTIVRTFPKfELLRAMNFVIIPALIGPLLGPTIGGL 163
Cdd:cd17326   81 NILYALAEYFPsnrkyvMLV-ARFLIGVGAGNVAVLRAYVAAASTLK-DRTRAMAVISAAQALGFIVGPALQAA 152
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
15-184 6.00e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 38.68  E-value: 6.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  15 KRYLPWVVATALFmeqldsTIINTAVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVS---GWMADRFGTRRVFSTAVAI 91
Cdd:cd17370  200 KAFWLYLLAVALF------ALGNFSFAFLILRAQELGLSAALIPLLYALFNLVYALAAypaGRLSDRIGRKKLLILGYLS 273
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  92 FTFASVLCGLSQNVPMLVAARILQGMGAAMMMPVGRLTIVRTFPKFelLRAMNFVIIPAL--IGPLLGPTIGGLIVHVTS 169
Cdd:cd17370  274 LALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAE--LRGTAYGLFNTVvgIGWLLASLIAGYLWDLIS 351
                        170
                 ....*....|....*
gi 327549383 170 WRVIFFVNVPVGLAA 184
Cdd:cd17370  352 PSAAFLFSAVLALIA 366
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
33-201 7.66e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 38.31  E-value: 7.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  33 STIINTAVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLCGLSQNVPMLVAAR 112
Cdd:cd17478   12 QGFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLV 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 113 ILQGMGAAMMMPVGrLTIVRTFPKFELLRAMNFVIIPALIGPLLGPTIGGLIVHVTSWRVIFFVNVPVGLAAQWLIHKHM 192
Cdd:cd17478   92 ALAGIGSAAFHPEG-ARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLR 170

                 ....*....
gi 327549383 193 PDYHGDAPR 201
Cdd:cd17478  171 PLKKPEAKK 179
MFS_1 pfam07690
Major Facilitator Superfamily;
12-158 7.74e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 38.55  E-value: 7.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383   12 SAIKRYLPWVVATALFMEQLDSTIINTAVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRR---VFSTA 88
Cdd:pfam07690 195 KALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRrllLALLL 274
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383   89 VAIFTFASVLCGLSQNVPMLVAARILQGMGAAMMMPVGRLTIVRTFPKFELLRAMNFVIIPALIGPLLGP 158
Cdd:pfam07690 275 LILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
325-423 8.55e-03

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 38.33  E-value: 8.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 325 AARLLKRFGYRQVLIIntVLIGATISLFATVSTSTPlALIVLLGLTQGVFNSLQFSSmnSMAYADIsSADTSMASTLASS 404
Cdd:cd17335  253 SSRLIQRFGHVGLLYL--GLLAYVVRWLLYSFLENP-WLVLPIELLHGLTFALVWAA--AVSYASA-AAPPGLRATAQGL 326
                         90
                 ....*....|....*....
gi 327549383 405 LQQMSMSFGLACGSLVTGW 423
Cdd:cd17335  327 LQGLYFGLGGGLGSLIGGY 345
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
39-176 9.33e-03

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 38.33  E-value: 9.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383  39 AVPSMAISLGVTPLSLKAVVTSYILSLAVCIPVSGWMADRFGTRRVFSTAVAIFTFASVLCGLSQNVPMLVAARILQGMG 118
Cdd:PRK11043  28 AFKAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVG 107
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549383 119 AAMMMPVGRLTIVRTFPKFELLRAmnFVIIPALIG--PLLGPTIGGLIVHVTSWRVIFFV 176
Cdd:PRK11043 108 VCSAAVIWQALVIDRYPAQKANRV--FATIMPLVAlsPALAPLLGAWLLNHFGWQAIFAT 165
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
71-125 9.36e-03

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 38.33  E-value: 9.36e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 327549383  71 VSGWMADRFGTRRVFSTAVAIFTFASVLCGLSQNVPMLVAARILQGMGAAMMMPV 125
Cdd:cd17358   60 LSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVV 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH