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Conserved domains on  [gi|327549387|gb|EGF33954|]
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Type IV fimbrial biogenesis protein PilX [Oxalobacteraceae bacterium IMCC9480]

Protein Classification

pilin; type II secretion system protein; pilin; type II secretion system protein; prepilin-type N-terminal cleavage/methylation domain-containing protein; prepilin-type N-terminal cleavage/methylation domain-containing protein; prepilin-type N-terminal cleavage/methylation domain-containing protein; type II secretion system protein; type II secretion system GspH family protein; type II secretion system protein; type II secretion system GspH family protein; type II secretion system protein; type II secretion system protein; pilus assembly PilX N-terminal domain-containing protein; pilus assembly PilX N-terminal domain-containing protein; pilus assembly PilX N-terminal domain-containing protein; pilus assembly protein; pilus assembly protein; pilus assembly protein( domain architecture ID 11468746)

pilin similar to fimbrial protein PilE, which is required for pilus biogenesis, as well as fimbrial protein PilA, which is responsible for the adhesive property of the pilus; type II secretion system protein similar to Pseudomonas aeruginosa type II secretion system protein H, which is involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins; required for the translocation of a variety of enzymes across the outer membrane; pilin similar to fimbrial protein PilE, which is required for pilus biogenesis, as well as fimbrial protein PilA, which is responsible for the adhesive property of the pilus; type II secretion system protein similar to Pseudomonas aeruginosa type II secretion system protein H, which is involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins; required for the translocation of a variety of enzymes across the outer membrane; prepilin-type N-terminal cleavage/methylation domain-containing protein resembles type IV pilins at the N-terminus; prepilin-type N-terminal cleavage/methylation domain-containing protein resembles type IV pilins at the N-terminus; prepilin-type N-terminal cleavage/methylation domain-containing protein resembles type IV pilins at the N-terminus; type II secretion system protein similar to Pseudomonas aeruginosa type II secretion system protein H, which is involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins; required for the translocation of a variety of enzymes across the outer membrane; type II secretion system GspH family protein similar to Pseudomonas aeruginosa type II secretion system protein H that is part of the system system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm; type II secretion system protein similar to Pseudomonas aeruginosa type II secretion system protein H, which is involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins; required for the translocation of a variety of enzymes across the outer membrane; type II secretion system GspH family protein similar to Pseudomonas aeruginosa type II secretion system protein H that is part of the system system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm; type II secretion system protein similar to Pseudomonas aeruginosa type II secretion system protein H, which is involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins; required for the translocation of a variety of enzymes across the outer membrane; type II secretion system protein similar to Pseudomonas aeruginosa type II secretion system protein H, which is involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins; required for the translocation of a variety of enzymes across the outer membrane; pilus assembly PilX N-terminal domain-containing protein similar to the N-terminal region of Pseudomonas aeruginosa type 4 fimbrial biogenesis protein PilX; pilus assembly PilX N-terminal domain-containing protein similar to the N-terminal region of Pseudomonas aeruginosa type 4 fimbrial biogenesis protein PilX; pilus assembly PilX N-terminal domain-containing protein similar to the N-terminal region of Pseudomonas aeruginosa type 4 fimbrial biogenesis protein PilX; pilus assembly protein PilX is essential for bacterial aggregation and adhesion, similar to Neisseria meningitidis pilin PilX which is responsible for type IV pilus conformational changes associated with signaling to endothelial cells; pilus assembly protein PilX is essential for bacterial aggregation and adhesion, similar to Neisseria meningitidis pilin PilX which is responsible for type IV pilus conformational changes associated with signaling to endothelial cells; pilus assembly protein PilX is essential for bacterial aggregation and adhesion, similar to Neisseria meningitidis pilin PilX which is responsible for type IV pilus conformational changes associated with signaling to endothelial cells

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PilX COG4726
Type IV pilus assembly protein PilX [Cell motility, Extracellular structures];
1-195 3.19e-36

Type IV pilus assembly protein PilX [Cell motility, Extracellular structures];


:

Pssm-ID: 443761 [Multi-domain]  Cd Length: 175  Bit Score: 124.44  E-value: 3.19e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549387   1 MTTSSTTwRILPREQGSTLLIGMLFLIILTLLGLSAALISKTDERMARNSRDRNIAFFAAESALRDARDDIhlpasrIQG 80
Cdd:COG4726    1 MKRRRLR-PLPRRQRGAALIVALILLLVLTLLGVAAMRSSLLEERMAGNLRDRQLAFQAAEAALRDAEAWL------RNA 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549387  81 ATGALADCSGATTKGLCLPAAAGDPQVWETTylTDPTRSVEYgemtsltaaqkfkvAPASGGVTAPPRYLIEALPDINGV 160
Cdd:COG4726   74 SAASLTGLSDCTAASNGLYTSWSDPVTWTDA--TATAVGVAY--------------ALGTDGVAATPRYIIEYLGDVTPP 137
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 327549387 161 SLSAKVPQ-KWLYRITAIGYGANANTSVIVQETIRP 195
Cdd:COG4726  138 TSGGSSSSgSNYYRITARGFGGNANTVVVLQSTYRR 173
 
Name Accession Description Interval E-value
PilX COG4726
Type IV pilus assembly protein PilX [Cell motility, Extracellular structures];
1-195 3.19e-36

Type IV pilus assembly protein PilX [Cell motility, Extracellular structures];


Pssm-ID: 443761 [Multi-domain]  Cd Length: 175  Bit Score: 124.44  E-value: 3.19e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549387   1 MTTSSTTwRILPREQGSTLLIGMLFLIILTLLGLSAALISKTDERMARNSRDRNIAFFAAESALRDARDDIhlpasrIQG 80
Cdd:COG4726    1 MKRRRLR-PLPRRQRGAALIVALILLLVLTLLGVAAMRSSLLEERMAGNLRDRQLAFQAAEAALRDAEAWL------RNA 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549387  81 ATGALADCSGATTKGLCLPAAAGDPQVWETTylTDPTRSVEYgemtsltaaqkfkvAPASGGVTAPPRYLIEALPDINGV 160
Cdd:COG4726   74 SAASLTGLSDCTAASNGLYTSWSDPVTWTDA--TATAVGVAY--------------ALGTDGVAATPRYIIEYLGDVTPP 137
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 327549387 161 SLSAKVPQ-KWLYRITAIGYGANANTSVIVQETIRP 195
Cdd:COG4726  138 TSGGSSSSgSNYYRITARGFGGNANTVVVLQSTYRR 173
PilX pfam13681
Type IV pilus assembly protein PilX C-term; This family is likely to be the C-terminal region ...
93-195 5.47e-16

Type IV pilus assembly protein PilX C-term; This family is likely to be the C-terminal region of type IV pilus assembly PilX or PilW proteins.


Pssm-ID: 433400  Cd Length: 93  Bit Score: 69.89  E-value: 5.47e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549387   93 TKGLCLPAAAGDPQV--WETTYLTDPTRsveygemtsltaaqkFKVAPASGGVTAPPRYLIEALPDI---NGVSLSAKVP 167
Cdd:pfam13681   1 AAGLCRAADGGPTPLntWTNTGSFTGLA---------------APAATGLLGVAAAPRYIIEYLGDNaggGSANATSATT 65
                          90       100
                  ....*....|....*....|....*...
gi 327549387  168 QKWLYRITAIGYGANANTSVIVQETIRP 195
Cdd:pfam13681  66 PGYVYRITARGFGGSAATQVVLQSTYRK 93
 
Name Accession Description Interval E-value
PilX COG4726
Type IV pilus assembly protein PilX [Cell motility, Extracellular structures];
1-195 3.19e-36

Type IV pilus assembly protein PilX [Cell motility, Extracellular structures];


Pssm-ID: 443761 [Multi-domain]  Cd Length: 175  Bit Score: 124.44  E-value: 3.19e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549387   1 MTTSSTTwRILPREQGSTLLIGMLFLIILTLLGLSAALISKTDERMARNSRDRNIAFFAAESALRDARDDIhlpasrIQG 80
Cdd:COG4726    1 MKRRRLR-PLPRRQRGAALIVALILLLVLTLLGVAAMRSSLLEERMAGNLRDRQLAFQAAEAALRDAEAWL------RNA 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549387  81 ATGALADCSGATTKGLCLPAAAGDPQVWETTylTDPTRSVEYgemtsltaaqkfkvAPASGGVTAPPRYLIEALPDINGV 160
Cdd:COG4726   74 SAASLTGLSDCTAASNGLYTSWSDPVTWTDA--TATAVGVAY--------------ALGTDGVAATPRYIIEYLGDVTPP 137
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 327549387 161 SLSAKVPQ-KWLYRITAIGYGANANTSVIVQETIRP 195
Cdd:COG4726  138 TSGGSSSSgSNYYRITARGFGGNANTVVVLQSTYRR 173
PilX pfam13681
Type IV pilus assembly protein PilX C-term; This family is likely to be the C-terminal region ...
93-195 5.47e-16

Type IV pilus assembly protein PilX C-term; This family is likely to be the C-terminal region of type IV pilus assembly PilX or PilW proteins.


Pssm-ID: 433400  Cd Length: 93  Bit Score: 69.89  E-value: 5.47e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327549387   93 TKGLCLPAAAGDPQV--WETTYLTDPTRsveygemtsltaaqkFKVAPASGGVTAPPRYLIEALPDI---NGVSLSAKVP 167
Cdd:pfam13681   1 AAGLCRAADGGPTPLntWTNTGSFTGLA---------------APAATGLLGVAAAPRYIIEYLGDNaggGSANATSATT 65
                          90       100
                  ....*....|....*....|....*...
gi 327549387  168 QKWLYRITAIGYGANANTSVIVQETIRP 195
Cdd:pfam13681  66 PGYVYRITARGFGGSAATQVVLQSTYRK 93
PilX_N pfam14341
PilX N-terminal; This domain is found at the N-terminus of the PilX prepilin-like proteins ...
15-65 5.05e-10

PilX N-terminal; This domain is found at the N-terminus of the PilX prepilin-like proteins which are involved in type 4 fimbrial biogenesis.


Pssm-ID: 464141 [Multi-domain]  Cd Length: 51  Bit Score: 52.91  E-value: 5.05e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 327549387   15 QGSTLLIGMLFLIILTLLGLSAALISKTDERMARNSRDRNIAFFAAESALR 65
Cdd:pfam14341   1 RGAALVVALLLLLVLTLLGVALIQGSLLEERMASNDRDRQQAFYAAEAGLE 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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