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Conserved domains on  [gi|332032069|gb|EGI71159|]
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UPF0465 protein C5orf33, partial [Acromyrmex echinatior]

Protein Classification

NAD(+)/NADH kinase( domain architecture ID 1904694)

NAD(+)/NADH kinase such as bacterial NAD(+) kinase, which catalyzes specifically the phosphorylation on the 2'-hydroxyl of the adenosine moiety of NAD to yield NADP, and is involved in regulating the intracellular balance of NAD and NADP, and yeast NADH kinase, which phosphorylates both NADH and NAD(+), with a preference for NADH

CATH:  2.60.200.30|3.40.50.12540
EC:  2.7.1.-
Gene Ontology:  GO:0016773|GO:0006741|GO:0019674|GO:0005524
SCOP:  4002957

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NadK super family cl43012
NAD kinase [Coenzyme transport and metabolism];
67-171 2.89e-12

NAD kinase [Coenzyme transport and metabolism];


The actual alignment was detected with superfamily member COG0061:

Pssm-ID: 439831 [Multi-domain]  Cd Length: 279  Bit Score: 62.85  E-value: 2.89e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332032069  67 KELARILCNLNVSYRIMKRIDDVKC-----VNWADLVITIGGDGTFLLASKLITNNKTPIFGINP-HPGistFtLPIEYS 140
Cdd:COG0061   20 EELAELLEERGIEVVLDEDTAVPGVpleelGEEADLVIVLGGDGTLLRAARLLAPLGIPILGINLgRLG---F-LTEIEP 95

                         90       100       110
                 ....*....|....*....|....*....|.
gi 332032069 141 TDIERIFEKLYAGDYIVLMRSRIRTVMTGEG 171
Cdd:COG0061   96 EELEEALERLLAGEYEVEERLLLEATVDRDG 126
 
Name Accession Description Interval E-value
NadK COG0061
NAD kinase [Coenzyme transport and metabolism];
67-171 2.89e-12

NAD kinase [Coenzyme transport and metabolism];


Pssm-ID: 439831 [Multi-domain]  Cd Length: 279  Bit Score: 62.85  E-value: 2.89e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332032069  67 KELARILCNLNVSYRIMKRIDDVKC-----VNWADLVITIGGDGTFLLASKLITNNKTPIFGINP-HPGistFtLPIEYS 140
Cdd:COG0061   20 EELAELLEERGIEVVLDEDTAVPGVpleelGEEADLVIVLGGDGTLLRAARLLAPLGIPILGINLgRLG---F-LTEIEP 95

                         90       100       110
                 ....*....|....*....|....*....|.
gi 332032069 141 TDIERIFEKLYAGDYIVLMRSRIRTVMTGEG 171
Cdd:COG0061   96 EELEEALERLLAGEYEVEERLLLEATVDRDG 126
PLN02929 PLN02929
NADH kinase
 56-172 6.10e-09

NADH kinase


Pssm-ID: 215502 [Multi-domain]  Cd Length: 301  Bit Score: 53.89  E-value: 6.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332032069  56 LAEHHR-QLTCEKELARILCNLNVSYRIMKRIDDVKCVNWADLVITIGGDGTFLLASKLItNNKTPIFGINPHPGI---- 130
Cdd:PLN02929  25 LEDRHKvHKDTVNFCKDILQQKSVDWECVLRNELSQPIRDVDLVVAVGGDGTLLQASHFL-DDSIPVLGVNSDPTQkdev 103

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 332032069 131 -----------STFTLPIEYSTDIERIFEKLYAGDYIVLMRSRIRTVMTGEGL 172
Cdd:PLN02929 104 eeysdefdarrSTGHLCAATAEDFEQVLDDVLFGRLKPTELSRISTVVNGTLL 156
NAD_kinase pfam01513
ATP-NAD kinase N-terminal domain; Members of this family include ATP-NAD kinases EC:2.7.1.23, ...
 95-148 3.88e-06

ATP-NAD kinase N-terminal domain; Members of this family include ATP-NAD kinases EC:2.7.1.23, which catalyzes the phosphorylation of NAD to NADP utilizing ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus. Also includes NADH kinases EC:2.7.1.86.


Pssm-ID: 426300 [Multi-domain]  Cd Length: 128  Bit Score: 44.28  E-value: 3.88e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 332032069   95 ADLVITIGGDGTFLLASKLITNNKTPIFGINP-HPGISTFTLPIEYSTDIERIFE 148
Cdd:pfam01513  74 VDLIIVLGGDGTALRAARLLQKAVIPILGVNTgVLGFLTEFEPEAAFELLERLLE 128
 
Name Accession Description Interval E-value
NadK COG0061
NAD kinase [Coenzyme transport and metabolism];
67-171 2.89e-12

NAD kinase [Coenzyme transport and metabolism];


Pssm-ID: 439831 [Multi-domain]  Cd Length: 279  Bit Score: 62.85  E-value: 2.89e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332032069  67 KELARILCNLNVSYRIMKRIDDVKC-----VNWADLVITIGGDGTFLLASKLITNNKTPIFGINP-HPGistFtLPIEYS 140
Cdd:COG0061   20 EELAELLEERGIEVVLDEDTAVPGVpleelGEEADLVIVLGGDGTLLRAARLLAPLGIPILGINLgRLG---F-LTEIEP 95

                         90       100       110
                 ....*....|....*....|....*....|.
gi 332032069 141 TDIERIFEKLYAGDYIVLMRSRIRTVMTGEG 171
Cdd:COG0061   96 EELEEALERLLAGEYEVEERLLLEATVDRDG 126
PLN02929 PLN02929
NADH kinase
 56-172 6.10e-09

NADH kinase


Pssm-ID: 215502 [Multi-domain]  Cd Length: 301  Bit Score: 53.89  E-value: 6.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332032069  56 LAEHHR-QLTCEKELARILCNLNVSYRIMKRIDDVKCVNWADLVITIGGDGTFLLASKLItNNKTPIFGINPHPGI---- 130
Cdd:PLN02929  25 LEDRHKvHKDTVNFCKDILQQKSVDWECVLRNELSQPIRDVDLVVAVGGDGTLLQASHFL-DDSIPVLGVNSDPTQkdev 103

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 332032069 131 -----------STFTLPIEYSTDIERIFEKLYAGDYIVLMRSRIRTVMTGEGL 172
Cdd:PLN02929 104 eeysdefdarrSTGHLCAATAEDFEQVLDDVLFGRLKPTELSRISTVVNGTLL 156
pnk PRK14076
bifunctional NADP phosphatase/NAD kinase;
65-163 3.45e-08

bifunctional NADP phosphatase/NAD kinase;


Pssm-ID: 237601 [Multi-domain]  Cd Length: 569  Bit Score: 52.04  E-value: 3.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332032069  65 CEKELARILCN-LNVSYRIMKRIDDVkcvnwaDLVITIGGDGTFLLASKLITNNKTPIFGINphpgISTFTLPIEYSTD- 142
Cdd:PRK14076 324 LESFLYNKLKNrLNEECNLIDDIEEI------SHIISIGGDGTVLRASKLVNGEEIPIICIN----MGTVGFLTEFSKEe 393

                         90       100
                 ....*....|....*....|.
gi 332032069 143 IERIFEKLYAGDYIVLMRSRI 163
Cdd:PRK14076 394 IFKAIDSIISGEYEIEKRTKL 414
ppnK PRK04539
inorganic polyphosphate/ATP-NAD kinase; Provisional
 86-164 1.19e-06

inorganic polyphosphate/ATP-NAD kinase; Provisional


Pssm-ID: 179862 [Multi-domain]  Cd Length: 296  Bit Score: 47.16  E-value: 1.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332032069  86 IDDVKCVNWADLVITIGGDGTFLLASKLITNNKTPIFGINP-HPGISTfTLPIEYSTD-IERIFE-KLYAGDYIVLMRSR 162
Cdd:PRK04539  60 VNKTELGQYCDLVAVLGGDGTFLSVAREIAPRAVPIIGINQgHLGFLT-QIPREYMTDkLLPVLEgKYLAEERILIEAAL 138


                 ..
gi 332032069 163 IR 164
Cdd:PRK04539 139 IR 140
ppnK PRK01911
inorganic polyphosphate/ATP-NAD kinase; Provisional
 54-161 2.16e-06

inorganic polyphosphate/ATP-NAD kinase; Provisional


Pssm-ID: 179352 [Multi-domain]  Cd Length: 292  Bit Score: 46.46  E-value: 2.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332032069  54 EILAEHHRQLTCEKELARILC-NLNVSYRIMKRIDDVKCVNWADLVITIGGDGTFLLASKLITNNKTPIFGINphPGIST 132
Cdd:PRK01911  23 DELEERGAEVLIEEKFLDFLKqDLKFHPSYDTFSDNEELDGSADMVISIGGDGTFLRTATYVGNSNIPILGIN--TGRLG 100

                         90       100       110
                 ....*....|....*....|....*....|.
gi 332032069 133 F--TLPIEystDIERIFEKLYAGDYIVLMRS 161
Cdd:PRK01911 101 FlaTVSKE---EIEETIDELLNGDYTIEERS 128
ppnK PRK03708
NAD(+) kinase;
95-172 2.81e-06

NAD(+) kinase;


Pssm-ID: 179635 [Multi-domain]  Cd Length: 277  Bit Score: 45.86  E-value: 2.81e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 332032069  95 ADLVITIGGDGTFLLASKlITNNKTPIFGINphPGISTFTLPIEYStDIERIFEKLYAGDYIVLMRSRIRTVMTGEGL 172
Cdd:PRK03708  58 VDFIIAIGGDGTILRIEH-KTKKDIPILGIN--MGTLGFLTEVEPE-ETFFALSRLLEGDYFIDERIKLRVYINGENV 131
NAD_kinase pfam01513
ATP-NAD kinase N-terminal domain; Members of this family include ATP-NAD kinases EC:2.7.1.23, ...
 95-148 3.88e-06

ATP-NAD kinase N-terminal domain; Members of this family include ATP-NAD kinases EC:2.7.1.23, which catalyzes the phosphorylation of NAD to NADP utilizing ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus. Also includes NADH kinases EC:2.7.1.86.


Pssm-ID: 426300 [Multi-domain]  Cd Length: 128  Bit Score: 44.28  E-value: 3.88e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 332032069   95 ADLVITIGGDGTFLLASKLITNNKTPIFGINP-HPGISTFTLPIEYSTDIERIFE 148
Cdd:pfam01513  74 VDLIIVLGGDGTALRAARLLQKAVIPILGVNTgVLGFLTEFEPEAAFELLERLLE 128
ppnK PRK01185
NAD(+) kinase;
95-173 7.20e-06

NAD(+) kinase;


Pssm-ID: 179241 [Multi-domain]  Cd Length: 271  Bit Score: 44.80  E-value: 7.20e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 332032069  95 ADLVITIGGDGTFLLAsklITNNKTPIFGINphPGISTFTLPIEYStDIERIFEKLYAGDYIVLMRSRIRTVMTGEGLY 173
Cdd:PRK01185  53 ADVIITIGGDGTILRT---LQRAKGPILGIN--MGGLGFLTEIEID-EVGSAIKKLIRGEYFIDERMKLKVYINGERLE 125
ppnK PRK02231
NAD(+) kinase;
56-125 7.26e-06

NAD(+) kinase;


Pssm-ID: 167337 [Multi-domain]  Cd Length: 272  Bit Score: 44.80  E-value: 7.26e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332032069  56 LAEHHRQLTCEKELARilcNLNVSYRIMKRIDDVKCvnWADLVITIGGDGTFLLASKLITNNKTPIFGIN 125
Cdd:PRK02231   9 LKERGYQVLVEKEIAE---QLNLPENHLASLEEIGQ--RAQLAIVIGGDGNMLGRARVLAKYDIPLIGIN 73
ppnK PRK01231
NAD(+) kinase;
55-125 2.29e-05

NAD(+) kinase;


Pssm-ID: 179257 [Multi-domain]  Cd Length: 295  Bit Score: 43.41  E-value: 2.29e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 332032069  55 ILAEHHRQLTCEKELARIL--CNLNVSYRimKRIDDVkcvnwADLVITIGGDGTFLLASKLITNNKTPIFGIN 125
Cdd:PRK01231  28 FLLDRGLEVILDEETAEVLpgHGLQTVSR--KLLGEV-----CDLVIVVGGDGSLLGAARALARHNVPVLGIN 93
ppnK PRK03372
inorganic polyphosphate/ATP-NAD kinase; Provisional
 95-157 8.32e-04

inorganic polyphosphate/ATP-NAD kinase; Provisional


Pssm-ID: 235121 [Multi-domain]  Cd Length: 306  Bit Score: 38.74  E-value: 8.32e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 332032069  95 ADLVITIGGDGTFLLASKLITNNKTPIFGIN-PHPGistFTLPIEYStDIERIFEKLYAGDYIV 157
Cdd:PRK03372  73 CELVLVLGGDGTILRAAELARAADVPVLGVNlGHVG---FLAEAEAE-DLDEAVERVVDRDYRV 132
ppnK PRK02155
NAD kinase;
95-163 7.46e-03

NAD kinase;


Pssm-ID: 179379 [Multi-domain]  Cd Length: 291  Bit Score: 36.07  E-value: 7.46e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 332032069  95 ADLVITIGGDGTFLLASKLITNNKTPIFGINpHPGISTFT-LPIEystDIERIFEKLYAGDYIV----LMRSRI 163
Cdd:PRK02155  64 ADLAVVLGGDGTMLGIGRQLAPYGVPLIGIN-HGRLGFITdIPLD---DMQETLPPMLAGNYEEeermLLEARV 133
pnk PRK14075
NAD(+) kinase;
95-123 8.45e-03

NAD(+) kinase;


Pssm-ID: 184489 [Multi-domain]  Cd Length: 256  Bit Score: 35.86  E-value: 8.45e-03
                         10        20
                 ....*....|....*....|....*....
gi 332032069  95 ADLVITIGGDGTFLLASKLITnnkTPIFG 123
Cdd:PRK14075  42 ADLIIVVGGDGTVLKAAKKVG---TPLVG 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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