NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|341899262|gb|EGT55197|]
View 

hypothetical protein CAEBREN_26272 [Caenorhabditis brenneri]

Protein Classification

serpentine receptor( domain architecture ID 366230)

serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Srd super family cl22924
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 22-338 1.57e-113

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


The actual alignment was detected with superfamily member pfam10319:

Pssm-ID: 419896  Cd Length: 310  Bit Score: 332.67  E-value: 1.57e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341899262   22 FVPKFFAFCSFLINPLFIFLILKDTKLNLGNYKYLLFYFSIFNMSCSMCDILVPICIFNYRYAFTIFVTEGYFETPSDFG 101
Cdd:pfam10319   9 YIPKIFGVLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVSDGPFFEYSELG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341899262  102 RYILSFRCSYITGTYAILHSHFLYRYMILVCDNYLDRYFFPFGLLCSIFYCLLHMAFWTLVAGFLSSRNLEnRLQYVRDP 181
Cdd:pfam10319  89 QHALSARCSFISASYAVLLIHFIYRYLVLFNPQLTRHYFRPWGILISILFFLFHGSVWTAICYFLLRANDE-IRDYIRED 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341899262  182 FEKYFGQDPFEINVIIAQYSEASEDFIQDTWIGIVLLSVVSFASLSLICFLGYLIVRELKKQTLFMSATTKRQQTQLIKA 261
Cdd:pfam10319 168 FRETYGVDSMDINMLGALYWEASDETVFRSWLGILLLTVISVYSIILYIVLGYKIMRKLNKMSVTMSKKTKRLQKQLLKA 247

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 341899262  262 LVIQTITPTIACFSPCFFflvsayVWnrwrtvnnYEIFEKRLLFRWLQHVSAIVMSIFPFFDPLSTLLVLPSLRRQL 338
Cdd:pfam10319 248 LIVQTIIPICISFSPCVL------AW--------YSPIFGIDLGRWNNYLEVIALSAFPFIDPLAIILCLPVYRNRI 310
 
Name Accession Description Interval E-value
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 22-338 1.57e-113

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 332.67  E-value: 1.57e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341899262   22 FVPKFFAFCSFLINPLFIFLILKDTKLNLGNYKYLLFYFSIFNMSCSMCDILVPICIFNYRYAFTIFVTEGYFETPSDFG 101
Cdd:pfam10319   9 YIPKIFGVLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVSDGPFFEYSELG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341899262  102 RYILSFRCSYITGTYAILHSHFLYRYMILVCDNYLDRYFFPFGLLCSIFYCLLHMAFWTLVAGFLSSRNLEnRLQYVRDP 181
Cdd:pfam10319  89 QHALSARCSFISASYAVLLIHFIYRYLVLFNPQLTRHYFRPWGILISILFFLFHGSVWTAICYFLLRANDE-IRDYIRED 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341899262  182 FEKYFGQDPFEINVIIAQYSEASEDFIQDTWIGIVLLSVVSFASLSLICFLGYLIVRELKKQTLFMSATTKRQQTQLIKA 261
Cdd:pfam10319 168 FRETYGVDSMDINMLGALYWEASDETVFRSWLGILLLTVISVYSIILYIVLGYKIMRKLNKMSVTMSKKTKRLQKQLLKA 247

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 341899262  262 LVIQTITPTIACFSPCFFflvsayVWnrwrtvnnYEIFEKRLLFRWLQHVSAIVMSIFPFFDPLSTLLVLPSLRRQL 338
Cdd:pfam10319 248 LIVQTIIPICISFSPCVL------AW--------YSPIFGIDLGRWNNYLEVIALSAFPFIDPLAIILCLPVYRNRI 310
 
Name Accession Description Interval E-value
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 22-338 1.57e-113

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 332.67  E-value: 1.57e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341899262   22 FVPKFFAFCSFLINPLFIFLILKDTKLNLGNYKYLLFYFSIFNMSCSMCDILVPICIFNYRYAFTIFVTEGYFETPSDFG 101
Cdd:pfam10319   9 YIPKIFGVLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVSDGPFFEYSELG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341899262  102 RYILSFRCSYITGTYAILHSHFLYRYMILVCDNYLDRYFFPFGLLCSIFYCLLHMAFWTLVAGFLSSRNLEnRLQYVRDP 181
Cdd:pfam10319  89 QHALSARCSFISASYAVLLIHFIYRYLVLFNPQLTRHYFRPWGILISILFFLFHGSVWTAICYFLLRANDE-IRDYIRED 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341899262  182 FEKYFGQDPFEINVIIAQYSEASEDFIQDTWIGIVLLSVVSFASLSLICFLGYLIVRELKKQTLFMSATTKRQQTQLIKA 261
Cdd:pfam10319 168 FRETYGVDSMDINMLGALYWEASDETVFRSWLGILLLTVISVYSIILYIVLGYKIMRKLNKMSVTMSKKTKRLQKQLLKA 247

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 341899262  262 LVIQTITPTIACFSPCFFflvsayVWnrwrtvnnYEIFEKRLLFRWLQHVSAIVMSIFPFFDPLSTLLVLPSLRRQL 338
Cdd:pfam10319 248 LIVQTIIPICISFSPCVL------AW--------YSPIFGIDLGRWNNYLEVIALSAFPFIDPLAIILCLPVYRNRI 310
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 22-339 2.89e-42

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 149.53  E-value: 2.89e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341899262   22 FVPKFFAFCSFLINPLFIFLILKDTKLNLGNYKYLLFYFSIFNMSCSMCDILVPICIFNYRYAFTIFVTEGYFETPSDFG 101
Cdd:pfam10326   3 IIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKSVG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341899262  102 RYILSFRCSYITGTYAILHSHFLYRYMILVCDNYLdRYFFPFGLLCSIFYCLLHMAFWTLVAGFLSSRNLENRlQYVRDP 181
Cdd:pfam10326  83 QILLALYCGFYGVSISLLAVQFIYRYLALCRPGKL-KYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETD-EYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341899262  182 FEKYFGQDPFEINVIIAQYSEASED----FIQDTWIGIVLLSVVSFASLSLICFLGYLIVRELKKQTLFMSATTKRQQTQ 257
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDENgskvIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQ 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341899262  258 LIKALVIQTITPTIACFSPCFFFLVSAyvwnrwrtvnnyeIFEKRllFRWLQHVSAIVMSIFPFFDPLSTLLVLPSLRRQ 337
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLP-------------LFNIE--IGFLSGIITATIALYPAIDPLPAMFIIKEYRNA 305


                  ..
gi 341899262  338 LK 339
Cdd:pfam10326 306 IK 307
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 26-339 2.50e-10

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 60.64  E-value: 2.50e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341899262   26 FFAFCSFLINPLFIFLILKDTKLNLGNYKYLLFYFSIFNMSCSMCDILVPICIFNYRYAFTIFVTE--GYFETPSDFGRY 103
Cdd:pfam10317   7 IFFILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIPNGVSMALISYGpcKYFGPWFCYSGY 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341899262  104 ILsFRCSYITGTYAILHShFLYRYMILvcdNYLDRYFFPFGLLCSIFYC---LLHMAFWTLVAGFLSSRNLENRLqyvrd 180
Cdd:pfam10317  87 SL-LQHFLLHSGWSLLLT-FYYRYYIL---KHVDPKRKKLILLIIIHYIpslSQLIVIFLSPTDFLPVEALTKEL----- 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341899262  181 pfekyFGQDPFEINVIIAQYSEASEDFIqdtwIGIVLLSVVSFASLSLICFLGYLIVRELKKQTLFMSATTKRQQTQLIK 260
Cdd:pfam10317 157 -----HPNYNLTDYTVTGFSDLQSFPAL----INTLIMTIPVFPIPIIILILRRKILKLLNSNSVNMSPTTKAQHRQLIK 227

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 341899262  261 ALVIQTITPTIACFSPCFFFLVSAYvwnrwrTVNNYEIFEkrllfrwlqHVSAIVMSIFPFFDPLSTLLVLPSLRRQLK 339
Cdd:pfam10317 228 GLTIQALLPLFSYIPGVTLYLLSQL------TGTEFLILE---------YFIFVLPALPPLLDPLITIYFVTPYRRAIL 291
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 211-295 1.40e-05

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 46.38  E-value: 1.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341899262  211 TWIGIVLLSVVSFASLSLICFLGYLIVRELKKQTLFMSATTKRQQTQLIKALVIQTITPTIACFSPCFFFLVSAYVWNRW 290
Cdd:pfam10318 184 TYFLICIVLLILILIIQILFFVFLTIYYLFKSVKSSLSKKTRKLQKKFFIALIIQVSIPLIVILIPLIYILFSIIFGYYN 263


                  ....*
gi 341899262  291 RTVNN 295
Cdd:pfam10318 264 QALNN 268
7TM_GPCR_Sri pfam10327
Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis ...
 31-285 1.14e-04

Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sri is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 313539  Cd Length: 303  Bit Score: 43.30  E-value: 1.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341899262   31 SFLINPLFIFLILKDTKlNLGNYKYLLFYFSIfnmSCSMCDI----------LVPICIFnyrYAFTIFVTegYFETPSDF 100
Cdd:pfam10327  22 SLILNLLGIYLIIFKSG-KIDNFRYYLLYFQI---SCTLTDIhltflmqpipLFPIIAG---YCNGFLAT--VFGISSHY 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341899262  101 GRYILSFrcsYITGTYAILHSHFLYRYMILVcdNYLDRYFFPFGLLCSIFYCLLHMAFWTLVAGFLSSRNLENRLQYVRD 180
Cdd:pfam10327  93 LMTIFVF---LLSFQLESLLLCFVRKHQAIA--KILSKHVIPKWLYIFLYILCHIFPFLTAFLFYQSGLSREEQLEYVKE 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341899262  181 PFEKYFGQ----DPFEInviiaqyseasedFIQDTWIGIVLLSVVSFASLS--LICFLGYLIVRELKKQTLFMSATTKRQ 254
Cdd:pfam10327 168 NYPEYLSQfsslPNFAI-------------YDYNPWLIVFGILAIFGGSLSflILVYLTVDMFRMLKRLRKKISAQTYQK 234

                         250       260       270
                  ....*....|....*....|....*....|.
gi 341899262  255 QTQLIKALVIQTITPTIACFSPCFFFLVSAY 285
Cdd:pfam10327 235 HRAALRSLIAQFATSPVCILPPFAFVVVVLF 265
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH