NCBI Conserved Domain Search

Conserved domains on [gi|343398698|gb|EGV11227|]

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hypothetical protein HMPREF9127_0010 [Parvimonas sp. oral taxon 393 str. F0440]

Protein Classification

macro domain-containing protein( domain architecture ID 1211)

macro domain-containing protein functions in the recognition, interpretation, and turnover of ADP-ribose (ADPr) signaling

CATH: 3.40.220.10

Gene Ontology: GO:0072570

PubMed: 26844395|15902274

SCOP: 4000521

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

Macro_SF super family

cl00019

macrodomain superfamily; Macrodomains are found in a variety of proteins with diverse cellular ...

3-86

8.39e-11

macrodomain superfamily; Macrodomains are found in a variety of proteins with diverse cellular functions, as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Macrodomains can recognize ADP-ribose (ADPr) in both its free and protein-linked forms, in related ligands, such as O-acyl-ADP-ribose (OAADPr), and even in ligands unrelated to ADPr. Macrodomains include the yeast macrodomain Poa1 which is a phosphatase of ADP-ribose-1"-phosphate, a by-product of tRNA splicing. Some macrodomains have ADPr-unrelated binding partners such as the coronavirus SUD-N (N-terminal subdomain) and SUD-M (middle subdomain) of the SARS-unique domain (SUD) which bind G-quadruplexes (unusual nucleic-acid structures formed by consecutive guanosine nucleotides). Macrodomains regulate a wide variety of cellular and organismal processes, including DNA damage repair, signal transduction, and immune response.

The actual alignment was detected with superfamily member PRK04143:

Pssm-ID: 469581 Cd Length: 264 Bit Score: 56.14 E-value: 8.39e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 343398698   3 RNKEQMLDFLVKAFIADSDNYKNMEIPEDETQKKVVLRSLMNIRIPRKMDDKVLEVQDEYLKLCAEEKRIVEIKDIPVVK 82
Cdd:PRK04143   2 PSQKARLEYLINYLQKEQLTSDVLPLPNDLEEQQDLLRALANVRPALPLSDEYLNLQDAYLQDENAERGVVDLKDLQPIK 81


                 ....*.
gi 343398698  83 D--IFL 86
Cdd:PRK04143  82 YdnIFL 87

Name

Accession

Description

Interval

E-value

PRK04143

protein-ADP-ribose hydrolase;

3-86

8.39e-11

protein-ADP-ribose hydrolase;

Pssm-ID: 235225 Cd Length: 264 Bit Score: 56.14 E-value: 8.39e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 343398698   3 RNKEQMLDFLVKAFIADSDNYKNMEIPEDETQKKVVLRSLMNIRIPRKMDDKVLEVQDEYLKLCAEEKRIVEIKDIPVVK 82
Cdd:PRK04143   2 PSQKARLEYLINYLQKEQLTSDVLPLPNDLEEQQDLLRALANVRPALPLSDEYLNLQDAYLQDENAERGVVDLKDLQPIK 81


                 ....*.
gi 343398698  83 D--IFL 86
Cdd:PRK04143  82 YdnIFL 87

Name

Accession

Description

Interval

E-value

PRK04143

protein-ADP-ribose hydrolase;

3-86

8.39e-11

protein-ADP-ribose hydrolase;

Pssm-ID: 235225 Cd Length: 264 Bit Score: 56.14 E-value: 8.39e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 343398698   3 RNKEQMLDFLVKAFIADSDNYKNMEIPEDETQKKVVLRSLMNIRIPRKMDDKVLEVQDEYLKLCAEEKRIVEIKDIPVVK 82
Cdd:PRK04143   2 PSQKARLEYLINYLQKEQLTSDVLPLPNDLEEQQDLLRALANVRPALPLSDEYLNLQDAYLQDENAERGVVDLKDLQPIK 81


                 ....*.
gi 343398698  83 D--IFL 86
Cdd:PRK04143  82 YdnIFL 87

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01