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Conserved domains on  [gi|343398705|gb|EGV11234|]
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collagen adhesin domain protein [Parvimonas sp. oral taxon 393 str. F0440]

Protein Classification

Cna B-type domain-containing protein( domain architecture ID 10529984)

Cna B-type domain-containing protein adopts a unique fold that resembles but is the inverse of immunoglobulin-like domains, similar to the repetitive B region of Staphylococcus aureus collagen-binding protein Cna that mediates bacterial adherence to collagen

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cna_B pfam05738
Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding ...
 73-129 1.43e-13

Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding surface protein. The structure of the repetitive B-region has been solved and forms a beta sandwich structure.


:

Pssm-ID: 461726 [Multi-domain]  Cd Length: 88  Bit Score: 61.49  E-value: 1.43e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 343398705   73 VKGEKTWDDANNQDGKRPKSITVKLIKqveNGQPVEVQrKEVKEGTDkkWTYEFKNL 129
Cdd:pfam05738   1 VSVTKVWDDNNNQDGIRPESITVQLLA---NGQKVGVT-KELTAANN--WTYTFTDL 51
Cna_B pfam05738
Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding ...
 10-65 4.01e-13

Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding surface protein. The structure of the repetitive B-region has been solved and forms a beta sandwich structure.


:

Pssm-ID: 461726 [Multi-domain]  Cd Length: 88  Bit Score: 60.34  E-value: 4.01e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 343398705   10 VVAQTQEVRegADKKWTYEFKNLPKY-EKGTEITYSIEEEAVAGY---VGALSGYNLTNT 65
Cdd:pfam05738  31 KVGVTKELT--AANNWTYTFTDLPKYdENGKEITYTVEEDAVPGYtttVDAKDGFTITNT 88
 
Name Accession Description Interval E-value
Cna_B pfam05738
Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding ...
 73-129 1.43e-13

Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding surface protein. The structure of the repetitive B-region has been solved and forms a beta sandwich structure.


Pssm-ID: 461726 [Multi-domain]  Cd Length: 88  Bit Score: 61.49  E-value: 1.43e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 343398705   73 VKGEKTWDDANNQDGKRPKSITVKLIKqveNGQPVEVQrKEVKEGTDkkWTYEFKNL 129
Cdd:pfam05738   1 VSVTKVWDDNNNQDGIRPESITVQLLA---NGQKVGVT-KELTAANN--WTYTFTDL 51
Cna_B pfam05738
Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding ...
 10-65 4.01e-13

Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding surface protein. The structure of the repetitive B-region has been solved and forms a beta sandwich structure.


Pssm-ID: 461726 [Multi-domain]  Cd Length: 88  Bit Score: 60.34  E-value: 4.01e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 343398705   10 VVAQTQEVRegADKKWTYEFKNLPKY-EKGTEITYSIEEEAVAGY---VGALSGYNLTNT 65
Cdd:pfam05738  31 KVGVTKELT--AANNWTYTFTDLPKYdENGKEITYTVEEDAVPGYtttVDAKDGFTITNT 88
CollagenBindB cd00222
Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates ...
 71-129 1.58e-12

Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by instances of this B region repetitive unit. The B region has one to four 23 kDa repeat units (B1-B4), which have been suggested to serve as 'stalks' that project the A region from the bacterial surface and thus facilitate bacterial adherence to collagen. Each B repeat unit has two highly similar domains (D1 and D2) placed side-by-side; both D1 and D2 are included in this model. They exhibit a unique inverse IgG-like domain fold.


Pssm-ID: 212461 [Multi-domain]  Cd Length: 92  Bit Score: 58.84  E-value: 1.58e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 343398705  71 VDVKGEKTWDDANNQDGKRPKSITVKLIKqveNGQPvEVQRKEVKEGTDkkWTYEFKNL 129
Cdd:cd00222    1 TDITVTKTWDDDDNQDGKRPESITVQLLA---NGKE-TGDTVTLTASND--WTYTFTNL 53
CollagenBindB cd00222
Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates ...
 21-66 3.05e-11

Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by instances of this B region repetitive unit. The B region has one to four 23 kDa repeat units (B1-B4), which have been suggested to serve as 'stalks' that project the A region from the bacterial surface and thus facilitate bacterial adherence to collagen. Each B repeat unit has two highly similar domains (D1 and D2) placed side-by-side; both D1 and D2 are included in this model. They exhibit a unique inverse IgG-like domain fold.


Pssm-ID: 212461 [Multi-domain]  Cd Length: 92  Bit Score: 55.76  E-value: 3.05e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 343398705  21 ADKKWTYEFKNLPKY-EKGTEITYSIEEEAVAGYV----GALSGYNLTNTH 66
Cdd:cd00222   42 ASNDWTYTFTNLPKYdENGKEITYTVKEVPVPGYTttvtGDDGGFTITNTH 92
 
Name Accession Description Interval E-value
Cna_B pfam05738
Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding ...
 73-129 1.43e-13

Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding surface protein. The structure of the repetitive B-region has been solved and forms a beta sandwich structure.


Pssm-ID: 461726 [Multi-domain]  Cd Length: 88  Bit Score: 61.49  E-value: 1.43e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 343398705   73 VKGEKTWDDANNQDGKRPKSITVKLIKqveNGQPVEVQrKEVKEGTDkkWTYEFKNL 129
Cdd:pfam05738   1 VSVTKVWDDNNNQDGIRPESITVQLLA---NGQKVGVT-KELTAANN--WTYTFTDL 51
Cna_B pfam05738
Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding ...
 10-65 4.01e-13

Cna protein B-type domain; This domain is found in Staphylococcus aureus collagen-binding surface protein. The structure of the repetitive B-region has been solved and forms a beta sandwich structure.


Pssm-ID: 461726 [Multi-domain]  Cd Length: 88  Bit Score: 60.34  E-value: 4.01e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 343398705   10 VVAQTQEVRegADKKWTYEFKNLPKY-EKGTEITYSIEEEAVAGY---VGALSGYNLTNT 65
Cdd:pfam05738  31 KVGVTKELT--AANNWTYTFTDLPKYdENGKEITYTVEEDAVPGYtttVDAKDGFTITNT 88
CollagenBindB cd00222
Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates ...
 71-129 1.58e-12

Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by instances of this B region repetitive unit. The B region has one to four 23 kDa repeat units (B1-B4), which have been suggested to serve as 'stalks' that project the A region from the bacterial surface and thus facilitate bacterial adherence to collagen. Each B repeat unit has two highly similar domains (D1 and D2) placed side-by-side; both D1 and D2 are included in this model. They exhibit a unique inverse IgG-like domain fold.


Pssm-ID: 212461 [Multi-domain]  Cd Length: 92  Bit Score: 58.84  E-value: 1.58e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 343398705  71 VDVKGEKTWDDANNQDGKRPKSITVKLIKqveNGQPvEVQRKEVKEGTDkkWTYEFKNL 129
Cdd:cd00222    1 TDITVTKTWDDDDNQDGKRPESITVQLLA---NGKE-TGDTVTLTASND--WTYTFTNL 53
CollagenBindB cd00222
Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates ...
 21-66 3.05e-11

Repeat unit of collagen-binding protein domain B; The collagen-binding protein mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by instances of this B region repetitive unit. The B region has one to four 23 kDa repeat units (B1-B4), which have been suggested to serve as 'stalks' that project the A region from the bacterial surface and thus facilitate bacterial adherence to collagen. Each B repeat unit has two highly similar domains (D1 and D2) placed side-by-side; both D1 and D2 are included in this model. They exhibit a unique inverse IgG-like domain fold.


Pssm-ID: 212461 [Multi-domain]  Cd Length: 92  Bit Score: 55.76  E-value: 3.05e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 343398705  21 ADKKWTYEFKNLPKY-EKGTEITYSIEEEAVAGYV----GALSGYNLTNTH 66
Cdd:cd00222   42 ASNDWTYTFTNLPKYdENGKEITYTVKEVPVPGYTttvtGDDGGFTITNTH 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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