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Conserved domains on  [gi|347520563|gb|EGY27694|]
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hdr-like menaquinol oxidoreductase iron-sulfur subunit 1 [Desulfovibrio sp. A2]

Protein Classification

4Fe-4S dicluster domain-containing protein( domain architecture ID 11586797)

4Fe-4S dicluster domain-containing protein such as Salmonella enterica thiosulfate reductase electron transfer subunit PhsB, a component of the PhsABC thiosulfate reductase that catalyzes the reduction of thiosulfate to sulfite and hydrogen sulfide, with menaquinol as the sole electron donor

Gene Ontology:  GO:0016491|GO:0046872|GO:0051539
SCOP:  3000020

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PsrB cd10551
polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial ...
 54-258 1.20e-86

polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial polysulfide reductase (PsrABC), an integral membrane-bound enzyme responsible for quinone-coupled reduction of polysulfides, a process important in extreme environments such as deep-sea vents and hot springs. Polysulfide reductase contains three subunits: a catalytic subunit PsrA, an electron transfer PsrB subunit and the hydrophobic transmembrane PsrC subunit. PsrB belongs to the DMSO reductase superfamily that contains [4Fe-4S] clusters which transfer the electrons from the A subunit to the hydrophobic integral membrane C subunit via the B subunit. In Shewanella oneidensis, which has highly diverse anaerobic respiratory pathways, PsrABC is responsible for H2S generation as well as its regulation via respiration of sulfur species. PsrB transfers electrons from PsrC (serving as quinol oxidase) to the catalytic subunit PsrA for reduction of corresponding electron acceptors. It has been shown that T. thermophilus polysulfide reductase could be a key energy-conserving enzyme of the respiratory chain, using polysulfide as the terminal electron acceptor and pumping protons across the membrane.


:

Pssm-ID: 319873 [Multi-domain]  Cd Length: 185  Bit Score: 255.53  E-value: 1.20e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563  54 MVIDTRKLesredyarI-----IDACHKVHNVPsiptkQEIKWIWTDKYDRVFTDDMSQHLSPavrekdylLLCNHCENP 128
Cdd:cd10551    1 MVIDLRKC--------IgcgacVVACKAENNVP-----PGVFRNRVLEYEVGEYPNVKRTFLP--------VLCNHCENP 59

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563 129 PCVRVCPTKATFKRADGIVVMDYHRCIGCRFCMAGCPYGARSFNFGDPRPYlkevnPAFPTRMRGVVEKCTFCSERLEVG 208
Cdd:cd10551   60 PCVKVCPTGATYKREDGIVLVDYDKCIGCRYCMAACPYGARYFNPEEPHEF-----GEVPVRPKGVVEKCTFCYHRLDEG 134

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 347520563 209 LLPACVEA-SNGAILFGDLDDPNSPVRKALAENFSIRRKPSIGTQPGVYYI 258
Cdd:cd10551  135 LLPACVEAcPTGARIFGDLDDPNSEVSKLLAERRAYVLKPELGTKPKVYYI 185
 
Name Accession Description Interval E-value
PsrB cd10551
polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial ...
 54-258 1.20e-86

polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial polysulfide reductase (PsrABC), an integral membrane-bound enzyme responsible for quinone-coupled reduction of polysulfides, a process important in extreme environments such as deep-sea vents and hot springs. Polysulfide reductase contains three subunits: a catalytic subunit PsrA, an electron transfer PsrB subunit and the hydrophobic transmembrane PsrC subunit. PsrB belongs to the DMSO reductase superfamily that contains [4Fe-4S] clusters which transfer the electrons from the A subunit to the hydrophobic integral membrane C subunit via the B subunit. In Shewanella oneidensis, which has highly diverse anaerobic respiratory pathways, PsrABC is responsible for H2S generation as well as its regulation via respiration of sulfur species. PsrB transfers electrons from PsrC (serving as quinol oxidase) to the catalytic subunit PsrA for reduction of corresponding electron acceptors. It has been shown that T. thermophilus polysulfide reductase could be a key energy-conserving enzyme of the respiratory chain, using polysulfide as the terminal electron acceptor and pumping protons across the membrane.


Pssm-ID: 319873 [Multi-domain]  Cd Length: 185  Bit Score: 255.53  E-value: 1.20e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563  54 MVIDTRKLesredyarI-----IDACHKVHNVPsiptkQEIKWIWTDKYDRVFTDDMSQHLSPavrekdylLLCNHCENP 128
Cdd:cd10551    1 MVIDLRKC--------IgcgacVVACKAENNVP-----PGVFRNRVLEYEVGEYPNVKRTFLP--------VLCNHCENP 59

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563 129 PCVRVCPTKATFKRADGIVVMDYHRCIGCRFCMAGCPYGARSFNFGDPRPYlkevnPAFPTRMRGVVEKCTFCSERLEVG 208
Cdd:cd10551   60 PCVKVCPTGATYKREDGIVLVDYDKCIGCRYCMAACPYGARYFNPEEPHEF-----GEVPVRPKGVVEKCTFCYHRLDEG 134

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 347520563 209 LLPACVEA-SNGAILFGDLDDPNSPVRKALAENFSIRRKPSIGTQPGVYYI 258
Cdd:cd10551  135 LLPACVEAcPTGARIFGDLDDPNSEVSKLLAERRAYVLKPELGTKPKVYYI 185
HybA COG0437
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ...
 50-258 1.97e-71

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];


Pssm-ID: 440206 [Multi-domain]  Cd Length: 184  Bit Score: 216.74  E-value: 1.97e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563  50 KRWAMVIDTRKLesredyariID------ACHKVHNVPsiptkQEIKWIWTDKYDRVFTDDMSQHLSPavrekdylLLCN 123
Cdd:COG0437    4 KRYGMVIDLTKC---------IGcracvvACKEENNLP-----VGVTWRRVRRYEEGEFPNVEWLFVP--------VLCN 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563 124 HCENPPCVRVCPTKATFKRADGIVVMDYHRCIGCRFCMAGCPYGARSFNfgdprpylkevnpafptRMRGVVEKCTFCSE 203
Cdd:COG0437   62 HCDDPPCVKVCPTGATYKREDGIVLVDYDKCIGCRYCVAACPYGAPRFN-----------------PETGVVEKCTFCAD 124

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 347520563 204 RLEVGLLPACVEA-SNGAILFGDLDDPNSPVRKALAENFSIRRKPSIGTQPGVYYI 258
Cdd:COG0437  125 RLDEGLLPACVEAcPTGALVFGDLDDPESEVSKRLAELPAYRLLPELGTKPSVYYL 180
PRK14993 PRK14993
tetrathionate reductase subunit TtrB;
121-258 2.00e-44

tetrathionate reductase subunit TtrB;


Pssm-ID: 184955 [Multi-domain]  Cd Length: 244  Bit Score: 150.02  E-value: 2.00e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563 121 LCNHCENPPCVRVCPTKATFKRADGIVVMDYHRCIGCRFCMAGCPYGARSFNfgdprpylKEVNPAfptrmrgvvEKCTF 200
Cdd:PRK14993  99 LCNHCDNPPCVPVCPVQATFQREDGIVVVDNKRCVGCAYCVQACPYDARFIN--------HETQTA---------DKCTF 161

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 347520563 201 CSERLEVGLLPACVEAS-NGAILFGDLDDPNSPVRKALAENFSIRR--KPSIGTQPGVYYI 258
Cdd:PRK14993 162 CVHRLEAGLLPACVESCvGGARIIGDIKDPHSRIATMLHQHRDAIKvlKPENGTSPHVFYL 222
DMSO_dmsB TIGR02951
DMSO reductase, iron-sulfur subunit; This family consists of the iron-sulfur subunit, or chain ...
 122-228 6.76e-30

DMSO reductase, iron-sulfur subunit; This family consists of the iron-sulfur subunit, or chain B, of an enzyme called the anaerobic dimethyl sulfoxide reductase. Chains A and B are catalytic, while chain C is a membrane anchor.


Pssm-ID: 131996 [Multi-domain]  Cd Length: 161  Bit Score: 109.82  E-value: 6.76e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563  122 CNHCENPPCVRVCPTKATFKRA-DGIVVMDYHRCIGCRFCMAGCPYGARSFNfgdprpylkevnpafptRMRGVVEKCTF 200
Cdd:TIGR02951  64 CNHCADPACVKNCPTGAMYKREeDGLVLVDQDKCIGCRYCVWACPYGAPQYD-----------------PQQGVMGKCDG 126

                          90       100
                  ....*....|....*....|....*....
gi 347520563  201 CSERLEVGLLPACVEAS-NGAILFGDLDD 228
Cdd:TIGR02951 127 CYDRVEKGLRPACVDACpMRALDFGPIDE 155
Fer4_11 pfam13247
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 122-226 8.20e-23

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 404184 [Multi-domain]  Cd Length: 99  Bit Score: 89.23  E-value: 8.20e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563  122 CNHCENPPCVRVCPTKATFKR-ADGIVVMDYHRCIGCRFCMAGCPYGArsfnfgdprPYLKEVNpafptrmrGVVEKCTF 200
Cdd:pfam13247  10 CRHCLNPPCKASCPVGAIYKDeETGAVLLDEKTCRGWRECVSACPYNI---------PRYNDET--------GKAEKCDM 72

                          90       100
                  ....*....|....*....|....*..
gi 347520563  201 CSERLEVGLLPACVEA-SNGAILFGDL 226
Cdd:pfam13247  73 CYDRVEAGLLPACVQTcPTGAMNFGDR 99
 
Name Accession Description Interval E-value
PsrB cd10551
polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial ...
 54-258 1.20e-86

polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial polysulfide reductase (PsrABC), an integral membrane-bound enzyme responsible for quinone-coupled reduction of polysulfides, a process important in extreme environments such as deep-sea vents and hot springs. Polysulfide reductase contains three subunits: a catalytic subunit PsrA, an electron transfer PsrB subunit and the hydrophobic transmembrane PsrC subunit. PsrB belongs to the DMSO reductase superfamily that contains [4Fe-4S] clusters which transfer the electrons from the A subunit to the hydrophobic integral membrane C subunit via the B subunit. In Shewanella oneidensis, which has highly diverse anaerobic respiratory pathways, PsrABC is responsible for H2S generation as well as its regulation via respiration of sulfur species. PsrB transfers electrons from PsrC (serving as quinol oxidase) to the catalytic subunit PsrA for reduction of corresponding electron acceptors. It has been shown that T. thermophilus polysulfide reductase could be a key energy-conserving enzyme of the respiratory chain, using polysulfide as the terminal electron acceptor and pumping protons across the membrane.


Pssm-ID: 319873 [Multi-domain]  Cd Length: 185  Bit Score: 255.53  E-value: 1.20e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563  54 MVIDTRKLesredyarI-----IDACHKVHNVPsiptkQEIKWIWTDKYDRVFTDDMSQHLSPavrekdylLLCNHCENP 128
Cdd:cd10551    1 MVIDLRKC--------IgcgacVVACKAENNVP-----PGVFRNRVLEYEVGEYPNVKRTFLP--------VLCNHCENP 59

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563 129 PCVRVCPTKATFKRADGIVVMDYHRCIGCRFCMAGCPYGARSFNFGDPRPYlkevnPAFPTRMRGVVEKCTFCSERLEVG 208
Cdd:cd10551   60 PCVKVCPTGATYKREDGIVLVDYDKCIGCRYCMAACPYGARYFNPEEPHEF-----GEVPVRPKGVVEKCTFCYHRLDEG 134

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 347520563 209 LLPACVEA-SNGAILFGDLDDPNSPVRKALAENFSIRRKPSIGTQPGVYYI 258
Cdd:cd10551  135 LLPACVEAcPTGARIFGDLDDPNSEVSKLLAERRAYVLKPELGTKPKVYYI 185
HybA COG0437
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ...
 50-258 1.97e-71

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];


Pssm-ID: 440206 [Multi-domain]  Cd Length: 184  Bit Score: 216.74  E-value: 1.97e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563  50 KRWAMVIDTRKLesredyariID------ACHKVHNVPsiptkQEIKWIWTDKYDRVFTDDMSQHLSPavrekdylLLCN 123
Cdd:COG0437    4 KRYGMVIDLTKC---------IGcracvvACKEENNLP-----VGVTWRRVRRYEEGEFPNVEWLFVP--------VLCN 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563 124 HCENPPCVRVCPTKATFKRADGIVVMDYHRCIGCRFCMAGCPYGARSFNfgdprpylkevnpafptRMRGVVEKCTFCSE 203
Cdd:COG0437   62 HCDDPPCVKVCPTGATYKREDGIVLVDYDKCIGCRYCVAACPYGAPRFN-----------------PETGVVEKCTFCAD 124

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 347520563 204 RLEVGLLPACVEA-SNGAILFGDLDDPNSPVRKALAENFSIRRKPSIGTQPGVYYI 258
Cdd:COG0437  125 RLDEGLLPACVEAcPTGALVFGDLDDPESEVSKRLAELPAYRLLPELGTKPSVYYL 180
PRK14993 PRK14993
tetrathionate reductase subunit TtrB;
121-258 2.00e-44

tetrathionate reductase subunit TtrB;


Pssm-ID: 184955 [Multi-domain]  Cd Length: 244  Bit Score: 150.02  E-value: 2.00e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563 121 LCNHCENPPCVRVCPTKATFKRADGIVVMDYHRCIGCRFCMAGCPYGARSFNfgdprpylKEVNPAfptrmrgvvEKCTF 200
Cdd:PRK14993  99 LCNHCDNPPCVPVCPVQATFQREDGIVVVDNKRCVGCAYCVQACPYDARFIN--------HETQTA---------DKCTF 161

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 347520563 201 CSERLEVGLLPACVEAS-NGAILFGDLDDPNSPVRKALAENFSIRR--KPSIGTQPGVYYI 258
Cdd:PRK14993 162 CVHRLEAGLLPACVESCvGGARIIGDIKDPHSRIATMLHQHRDAIKvlKPENGTSPHVFYL 222
DMSOR_beta_like cd16371
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 73-224 5.06e-39

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319893 [Multi-domain]  Cd Length: 140  Bit Score: 132.69  E-value: 5.06e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563  73 ACHKVHNVPsiptkQEIKWIWTDKY-DRVFTDDMSQHLSPAvrekdylllCNHCENPPCVRVCPTKATFKRADGIVVMDY 151
Cdd:cd16371   18 ACKDKNDLP-----PGVNWRRVYEYeGGEFPEVFAYFLSMS---------CNHCENPACVKVCPTGAITKREDGIVVVDQ 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 347520563 152 HRCIGCRFCMAGCPYGARSFNfgdprpylKEvnpafptrmRGVVEKCTFCSERLEVGLLPACVEA-SNGAILFG 224
Cdd:cd16371   84 DKCIGCGYCVWACPYGAPQYN--------PE---------TGKMDKCDMCVDRLDEGEKPACVAAcPTRALDFG 140
EBDH_beta cd10555
beta subunit of ethylbenzene-dehydrogenase (EBDH); This subfamily includes ethylbenzene ...
 121-258 5.18e-37

beta subunit of ethylbenzene-dehydrogenase (EBDH); This subfamily includes ethylbenzene dehydrogenase (EBDH, EC 1.17.99.2), a member of the DMSO reductase family. EBDH oxidizes the hydrocarbon ethylbenzene to (S)-1-phenylethanol. It is a heterotrimer, with the alpha subunit containing the catalytic center with a molybdenum held by two molybdopterin-guanine dinucleotides, the beta subunit containing four iron-sulfur clusters (the electron transfer subunit) and the gamma subunit containing a methionine and a lysine as axial heme ligands. During catalysis, electrons produced by substrate oxidation are transferred to a heme in the gamma subunit and then presumably to a separate cytochrome involved in nitrate respiration.


Pssm-ID: 319877 [Multi-domain]  Cd Length: 316  Bit Score: 132.81  E-value: 5.18e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563 121 LCNHCENPPCVRVCPTKATFKRA-DGIVVMDYHRCIGCRFCMAGCPYGARSFNFgdprpylkevnpafptrMRGVVEKCT 199
Cdd:cd10555  132 ICNHCTNPACLAACPRKAIYKREeDGIVLVDQDRCRGYRYCVEACPYKKIYFNP-----------------VEQKSEKCI 194

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 347520563 200 FCSERLEVGLLPACVEASNGAILF-GDLDDPNSPVRKaLAENF--SIRRKPSIGTQPGVYYI 258
Cdd:cd10555  195 FCYPRIEKGVAPACARQCVGRIRFvGYLDDEESPVYK-LVKKWkvALPLHPEYGTEPNVFYV 255
HybA_like cd10561
the FeS subunit of hydrogenase 2; This subfamily includes the beta-subunit of hydrogenase 2 ...
 122-228 2.70e-33

the FeS subunit of hydrogenase 2; This subfamily includes the beta-subunit of hydrogenase 2 (Hyd-2), an enzyme that catalyzes the reversible oxidation of H2 to protons and electrons. Hyd-2 is membrane-associated and forms an unusual heterotetrameric [NiFe]-hydrogenase in that it lacks the typical cytochrome b membrane anchor subunit that transfers electrons to the quinone pool. The electron transfer subunit of Hyd-2 (HybA) which is predicted to contain four iron-sulfur clusters, is essential for electron transfer from Hyd-2 to menaquinone/demethylmenaquinone (MQ/DMQ) to couple hydrogen oxidation to fumarate reduction.


Pssm-ID: 319883 [Multi-domain]  Cd Length: 196  Bit Score: 119.62  E-value: 2.70e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563 122 CNHCENPPCVRVCPTKATFKRADGIVVMDYHRCIGCRFCMAGCPYGARSFNFGDPRPylkevnpafptrmrgVVEKCTFC 201
Cdd:cd10561   69 CMHCLDPACVSACPVGALRKTPEGPVTYDEDKCIGCRYCMVACPFNIPKYEWDSANP---------------KIRKCTMC 133

                         90       100
                 ....*....|....*....|....*...
gi 347520563 202 SERLEVGLLPACVEA-SNGAILFGDLDD 228
Cdd:cd10561  134 YDRLKEGKQPACVEAcPTGALLFGKREE 161
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
 73-224 2.63e-32

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 115.18  E-value: 2.63e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563  73 ACHKVHNVPSIPTKQEIKWIWTDKYDRVFTDDMsqhlspavrekdylllCNHCENPPCVRVCPTKATFKRADGIVVMDYH 152
Cdd:cd04410   17 ACKQEHGLRPGPDWSRIKVIEGGGLERAFLPVS----------------CMHCEDPPCVKACPTGAIYKDEDGIVLIDED 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 347520563 153 RCIGCRFCMAGCPYGARSFNFGdprpylkevnpafptrmRGVVEKCTFCSERLEVGLLPACVEA-SNGAILFG 224
Cdd:cd04410   81 KCIGCGSCVEACPYGAIVFDPE-----------------PGKAVKCDLCGDRLDEGLEPACVKAcPTGALTFG 136
DMSO_dmsB TIGR02951
DMSO reductase, iron-sulfur subunit; This family consists of the iron-sulfur subunit, or chain ...
 122-228 6.76e-30

DMSO reductase, iron-sulfur subunit; This family consists of the iron-sulfur subunit, or chain B, of an enzyme called the anaerobic dimethyl sulfoxide reductase. Chains A and B are catalytic, while chain C is a membrane anchor.


Pssm-ID: 131996 [Multi-domain]  Cd Length: 161  Bit Score: 109.82  E-value: 6.76e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563  122 CNHCENPPCVRVCPTKATFKRA-DGIVVMDYHRCIGCRFCMAGCPYGARSFNfgdprpylkevnpafptRMRGVVEKCTF 200
Cdd:TIGR02951  64 CNHCADPACVKNCPTGAMYKREeDGLVLVDQDKCIGCRYCVWACPYGAPQYD-----------------PQQGVMGKCDG 126

                          90       100
                  ....*....|....*....|....*....
gi 347520563  201 CSERLEVGLLPACVEAS-NGAILFGDLDD 228
Cdd:TIGR02951 127 CYDRVEKGLRPACVDACpMRALDFGPIDE 155
FDH_beta_like cd16366
beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family ...
 122-224 7.25e-28

beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family contains beta FeS subunits of several dehydrogenases in the DMSO reductase superfamily, including formate dehydrogenase N (FDH-N), tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N is a major component of nitrate respiration of Escherichia coli; it catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate to a cytochrome. W-FDH contains a tungsten instead of molybdenum at the catalytic center and seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate.


Pssm-ID: 319888 [Multi-domain]  Cd Length: 156  Bit Score: 104.40  E-value: 7.25e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563 122 CNHCENPPCVRVCPTKATFKRADGIVVMDYHRCIGCRFCMAGCPYGARSFNFGDPRPYlkevnpafptrmrgvveKCTFC 201
Cdd:cd16366   70 CMHCTDAGCLAACPTGAIIRTETGTVVVDPETCIGCGYCVNACPFDIPRFDEETGRVA-----------------KCTLC 132

                         90       100
                 ....*....|....*....|....
gi 347520563 202 SERLEVGLLPACVEA-SNGAILFG 224
Cdd:cd16366  133 YDRISNGLQPACVKTcPTGALTFG 156
DMSOR_beta_like cd16374
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 122-228 6.04e-27

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319896 [Multi-domain]  Cd Length: 139  Bit Score: 101.58  E-value: 6.04e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563 122 CNHCENPPCVRVCPTKATFKRADGIVVMDYHRCIGCRFCMAGCPYGARSFNfgdprpylkevnpafptRMRGVVEKCTFC 201
Cdd:cd16374   43 CRHCEDAPCMEVCPTGAIYRDEDGAVLVDPDKCIGCGMCAMACPFGVPRFD-----------------PSLKVAVKCDLC 105

                         90       100
                 ....*....|....*....|....*...
gi 347520563 202 SERLEVGLLPACVEA-SNGAILFGDLDD 228
Cdd:cd16374  106 IDRRREGKLPACVEAcPTGALKFGDIEE 133
NarH_like cd16365
beta FeS subunits DMSOR NarH-like family; This subfamily contains beta FeS subunits of several ...
 121-258 1.65e-26

beta FeS subunits DMSOR NarH-like family; This subfamily contains beta FeS subunits of several DMSO reductase superfamily, including nitrate reductase A, ethylbenzene dehydrogenase and selenate reductase. DMSO Reductase (DMSOR) family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. . The beta subunits of DMSOR contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system. Nitrate reductase A contains three subunits (the catalytic subunit NarG, the catalytic subunit NarH with four [Fe-S] clusters, and integral membrane subunit NarI) and often forms a respiratory chain with the formate dehydrogenase via the lipid soluble quinol pool. Ethylbenzene dehydrogenase oxidizes the hydrocarbon ethylbenzene to (S)-1-phenylethanol. Selenate reductase catalyzes reduction of selenate to selenite in bacterial species that can obtain energy by respiring anaerobically with selenate as the terminal electron acceptor.


Pssm-ID: 319887 [Multi-domain]  Cd Length: 201  Bit Score: 102.27  E-value: 1.65e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563 121 LCNHCENPPCVRVCPTKATFKRA-DGIVVMDYHRCIGCRFCMAGCPYGARSFNFgdprpylkevnpafptrMRGVVEKCT 199
Cdd:cd16365   72 LCNHCTNPACLAACPRGAIYKREeDGIVLIDQKRCRGYRKCVEQCPYKKIYFNG-----------------LSRVSEKCI 134

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 347520563 200 FCSERLEVGLLPACVEASNGAI-LFGDLDD-PNSPVRKALAE-NFSIRRKPSIGTQPGVYYI 258
Cdd:cd16365  135 ACYPRIEGGDPTRCMSACVGRIrLQGFLDDnPKSPVTKLIRHwKVALPLHPEYGTEPNIYYV 196
TH_beta_N cd10552
N-terminal FeS domain of pyrogallol-phloroglucinol transhydroxylase (TH), beta subunit; This ...
 117-257 1.71e-26

N-terminal FeS domain of pyrogallol-phloroglucinol transhydroxylase (TH), beta subunit; This family includes the beta subunit of pyrogallol-phloroglucinol transhydroxylase (TH), a cytoplasmic molybdenum (Mo) enzyme from anaerobic microorganisms like Pelobacter acidigallici and Desulfitobacterium hafniense which catalyzes the conversion of pyrogallol to phloroglucinol, an important building block of plant polymers. TH belongs to the DMSO reductase (DMSOR) family; it is a heterodimer consisting of a large alpha catalytic subunit and a small beta FeS subunit. The beta subunit has two domains with the N-terminal domain containing three [4Fe-4S] centers and a seven-stranded, mainly antiparallel beta-barrel domain. In the anaerobic bacterium Pelobacter acidigallici, gallic acid, pyrogallol, phloroglucinol, or phloroglucinol carboxylic acid are fermented to three molecules of acetate (plus CO2), and TH is the key enzyme in the fermentation pathway, which converts pyrogallol to phloroglucinol in the absence of O2.


Pssm-ID: 319874 [Multi-domain]  Cd Length: 186  Bit Score: 101.63  E-value: 1.71e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563 117 DYL-LLCNHCENPPCVRVCPTKATFKRADGIVVMDYHRCIGCRFCMAGCPYGARSFNfgdprpylKEVNpafptrmrgVV 195
Cdd:cd10552   58 AYLpVPCNHCDNAPCIKAAKDGAVYKRDDGIVIIDPEKAKGQKQLVDACPYGAIYWN--------EELQ---------VP 120

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 347520563 196 EKCTFCSERLEVG-LLPACVEA-SNGAILFGDLDDPNSpvRKALAENFSIRRKPSIGTQPGVYY 257
Cdd:cd10552  121 QKCTFCAHLLDDGwKEPRCVQAcPTGALRFGKLEDEEM--AAKAAEEGLEVLHPELGTKPRVYY 182
FDH_b_like cd10562
uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes ...
 122-228 4.61e-26

uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes the beta-subunit of formate dehydrogenases that are as yet uncharacterized. Members of the DMSO reductase family include formate dehydrogenase N and O (FDH-N, FDH-O) and tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N, a major component of nitrate respiration of Escherichia coli, is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. It forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. W-FDH contains a tungsten instead of molybdenum at the catalytic center. This enzyme seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It is a heterodimer of a large and a small subunit; the large subunit harbors the W site and one [4Fe-4S] center and the small subunit, containing three [4Fe-4S] clusters, functions to transfer electrons.


Pssm-ID: 319884 [Multi-domain]  Cd Length: 161  Bit Score: 99.68  E-value: 4.61e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563 122 CNHCENPPCVRVCPTKATFKRADGIVVMDYHRCIGCRFCMAGCPYGARSFNfgdprpylkevnpafptRMRGVVEKCTFC 201
Cdd:cd10562   70 CMHCTDAACVKVCPTGALYKTENGAVVVDEDKCIGCGYCVAACPFDVPRYD-----------------ETTNKITKCTLC 132

                         90       100
                 ....*....|....*....|....*...
gi 347520563 202 SERLEVGLLPACVEA-SNGAILFGDLDD 228
Cdd:cd10562  133 FDRIENGMQPACVKTcPTGALTFGDRDE 160
SER_beta cd10556
Beta subunit of selenate reductase; This subfamily includes beta FeS subunit of selenate ...
 121-258 1.08e-25

Beta subunit of selenate reductase; This subfamily includes beta FeS subunit of selenate reductase (SER), a member of the DMSO reductase family. SER catalyzes the reduction of selenate to selenite in bacterial species that can obtain energy by respiring anaerobically with selenate as the terminal electron acceptor. The enzyme comprises three subunits SerABC, forming a heterotrimer, with the catalytic component (alpha-subunit), iron-sulfur protein (beta-subunit) and monomeric b-type heme-containing gamma subunit. Beta subunit contains coordinating one [3Fe-4S] cluster and three [4Fe-4S] clusters and functions as electron carrier.


Pssm-ID: 319878 [Multi-domain]  Cd Length: 287  Bit Score: 102.15  E-value: 1.08e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563 121 LCNHCENPPCVRVCPTKATFKRA-DGIVVMDYHRCIGCRFCMAGCPYGARSFNFgdprpylkevnpafptrMRGVVEKCT 199
Cdd:cd10556  140 ICNHCTYPACLAACPRKAIYKREeDGIVLIDQERCRGYRECVEACPYKKPMYNP-----------------TTRVSEKCI 202

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563 200 FCSERLEVGLLPACVEASNGAI-LFGDLDDPNSPVRKALAEN---FSIRRK-------PSIGTQPGVYYI 258
Cdd:cd10556  203 GCYPRIEEGDQTQCVSACIGKIrLQGFINTPPDARWADDRDNpidFLVHIKkvalplyPQFGTEPNVYYI 272
NarH_beta-like cd10557
beta subunit of nitrate reductase A (NarH) and similar proteins; This subfamily includes ...
 121-221 2.20e-24

beta subunit of nitrate reductase A (NarH) and similar proteins; This subfamily includes nitrate reductase A, a member of the DMSO reductase family. The respiratory nitrate reductase complex (NarGHI) from E. coli is a heterotrimer, with the catalytic subunit (NarG) with a molybdo-bis (molybdopterin guanine dinucleotide) cofactor and an [Fe-S] cluster, the electron transfer subunit (NarH) with four [Fe-S] clusters, and the integral membrane subunit (NarI) with two b-type hemes. Nitrate reductase A often forms a respiratory chain with the formate dehydrogenase via the lipid soluble quinol pool. Electron transfer from formate to nitrate is coupled to proton translocation across the cytoplasmic membrane generating proton motive force by a redox loop mechanism. Demethylmenaquinol (DMKH2) has been shown to be a good substrate for NarGHI in nitrate respiration in E. coli.


Pssm-ID: 319879 [Multi-domain]  Cd Length: 363  Bit Score: 99.74  E-value: 2.20e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563 121 LCNHCENPPCVRVCPTKATFKRA-DGIVVMDYHRCIGCRFCMAGCPYGARSFNFGDprpylkevnpafptrmrGVVEKCT 199
Cdd:cd10557  178 ICNHCLNPACVAACPSGAIYKREeDGIVLIDQDRCRGWRMCVSACPYKKVYYNWKT-----------------GKSEKCI 240

                         90       100
                 ....*....|....*....|..
gi 347520563 200 FCSERLEVGLLPACVEASNGAI 221
Cdd:cd10557  241 FCYPRLEAGQPTVCSETCVGRI 262
PhsB_like cd10553
uncharacterized beta subfamily of DMSO Reductase similar to Desulfonauticus sp PhsB; This ...
 122-216 3.13e-24

uncharacterized beta subfamily of DMSO Reductase similar to Desulfonauticus sp PhsB; This family includes beta FeS subunits of anaerobic DMSO reductase (DMSOR) superfamily that have yet to be characterized. DMSOR consists of a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and the tungsten-containing formate dehydrogenase (FDH-T). Examples of heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319875 [Multi-domain]  Cd Length: 146  Bit Score: 94.74  E-value: 3.13e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563 122 CNHCENPPCVRVCPTKATFKR-ADGIVVMDYHRCIGCRFCMAGCPYGARSFnfgdprpylkevNPAfptrmRGVVEKCTF 200
Cdd:cd10553   58 CFHCENPWCVKACPTGAMQKReKDGIVYVDQELCIGCKACIEACPWGIPQW------------NPA-----TGKVVKCDY 120

                         90
                 ....*....|....*.
gi 347520563 201 CSERLEVGLLPACVEA 216
Cdd:cd10553  121 CMDRIDQGLKPACVTG 136
FDH-N cd10558
The beta FeS subunit of formate dehydrogenase-N (FDH-N); This subfamily contains beta FeS ...
 122-228 2.30e-23

The beta FeS subunit of formate dehydrogenase-N (FDH-N); This subfamily contains beta FeS subunit of formate dehydrogenase-N (FDH-N), a member of the DMSO reductase family. FDH-N is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. Thus, FDH-N is a major component of nitrate respiration of Escherichia coli. This integral membrane enzyme forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups.


Pssm-ID: 319880 [Multi-domain]  Cd Length: 208  Bit Score: 93.99  E-value: 2.30e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563 122 CNHCENPPCVRVCPT-KATFKRADGIVVMDYHRCIGCRFCMAGCPYGARSFNFGDPRPYlkevnpafptrmrgvveKCTF 200
Cdd:cd10558   70 CMHCADPGCLKACPSpGAIVQYANGIVDFQSDKCIGCGYCIKGCPFDIPRISKDDNKMY-----------------KCTL 132

                         90       100
                 ....*....|....*....|....*....
gi 347520563 201 CSERLEVGLLPACVEA-SNGAILFGDLDD 228
Cdd:cd10558  133 CSDRVSVGLEPACVKTcPTGALHFGTKED 161
FDH-O_like cd10560
beta subunit of formate dehydrogenase O (FDH-O) and similar proteins; This subfamily includes ...
 122-228 4.24e-23

beta subunit of formate dehydrogenase O (FDH-O) and similar proteins; This subfamily includes beta subunit of formate dehydrogenase family O (FDH-O), which is highly homologous to formate dehydrogenase N (FDH-N), a member of the DMSO reductase family. In E. coli three formate dehydrogenases are synthesized that are capable of oxidizing formate; Fdh-H, couples formate disproportionation to hydrogen and CO2, and is part of the cytoplasmically oriented formate hydrogenlyase complex, while FDH-N and FDH-O indicate their respective induction after growth with nitrate and oxygen. Little is known about FDH-O, although it shows formate oxidase activity during aerobic growth and is also synthesized during nitrate respiration, similar to FDH-N.


Pssm-ID: 319882 [Multi-domain]  Cd Length: 225  Bit Score: 93.60  E-value: 4.24e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563 122 CNHCENPPCVRVCPTKATFKRADGIVVMDYHRCIGCRFCMAGCPYGARSFNFGDprpylkevnpafptrmrGVVEKCTFC 201
Cdd:cd10560   78 CKHCTDAGCLEACPTGAIFRTEFGTVYIQPDICNGCGYCVAACPFGVIDRNEET-----------------GRAHKCTLC 140

                         90       100
                 ....*....|....*....|....*...
gi 347520563 202 SERLEVGLLPACVEA-SNGAILFGDLDD 228
Cdd:cd10560  141 YDRLKDGLEPACAKAcPTGSIQFGPLEE 168
Fer4_11 pfam13247
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 122-226 8.20e-23

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 404184 [Multi-domain]  Cd Length: 99  Bit Score: 89.23  E-value: 8.20e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563  122 CNHCENPPCVRVCPTKATFKR-ADGIVVMDYHRCIGCRFCMAGCPYGArsfnfgdprPYLKEVNpafptrmrGVVEKCTF 200
Cdd:pfam13247  10 CRHCLNPPCKASCPVGAIYKDeETGAVLLDEKTCRGWRECVSACPYNI---------PRYNDET--------GKAEKCDM 72

                          90       100
                  ....*....|....*....|....*..
gi 347520563  201 CSERLEVGLLPACVEA-SNGAILFGDL 226
Cdd:pfam13247  73 CYDRVEAGLLPACVQTcPTGAMNFGDR 99
HycB_like cd10554
HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a ...
 122-216 7.04e-22

HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a membrane-associated formate hydrogenlyase system (FHL-1) in Escherichia coli that breaks down formate, produced during anaerobic fermentation, to H2 and CO2. FHL-1 consists of formate dehydrogenase H (FDH-H) and the hydrogenase 3 complex (Hyd-3). HycB is thought to code for the [4Fe-4S] ferredoxin subunit of hydrogenase 3, which functions as an intermediate electron carrier protein between hydrogenase 3 and formate dehydrogenase. HydN codes for the [4Fe-4S] ferredoxin subunit of FDH-H; a hydN in-frame deletion mutation causes only weak reduction in hydrogenase activity, but loss of more than 60% of FDH-H activity. This pathway is only active at low pH and high formate concentrations, and is thought to provide a detoxification/de-acidification system countering the buildup of formate during fermentation.


Pssm-ID: 319876 [Multi-domain]  Cd Length: 149  Bit Score: 88.47  E-value: 7.04e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563 122 CNHCENPPCVRVCPTKATfKRADGIVVMDYHRCIGCRFCMAGCPYGARSFNFGDPRPYLKEVNPafptrmRGVVEKCTFC 201
Cdd:cd10554   56 CRQCEDAPCANVCPVGAI-SQEDGVVQVDEERCIGCKLCVLACPFGAIEMAPTTVPGVDWERGP------RAVAVKCDLC 128

                         90
                 ....*....|....*
gi 347520563 202 SERLEVgllPACVEA 216
Cdd:cd10554  129 AGREGG---PACVEA 140
NarY COG1140
Nitrate reductase beta subunit [Energy production and conversion, Inorganic ion transport and ...
 121-215 7.13e-22

Nitrate reductase beta subunit [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 440755 [Multi-domain]  Cd Length: 485  Bit Score: 94.10  E-value: 7.13e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563 121 LCNHCENPPCVRVCPTKATFKRA-DGIVVMDYHRCIGCRFCMAGCPYGARSFNFGdprpylkevnpafptrmRGVVEKCT 199
Cdd:COG1140  181 ICEHCLNPACVASCPSGAIYKREeDGIVLVDQDKCRGWRMCVSGCPYKKVYFNWK-----------------TGKAEKCI 243

                         90
                 ....*....|....*.
gi 347520563 200 FCSERLEVGLLPACVE 215
Cdd:COG1140  244 FCYPRIEAGQPTVCSE 259
PRK10882 PRK10882
hydrogenase 2 operon protein HybA;
3-224 1.54e-21

hydrogenase 2 operon protein HybA;


Pssm-ID: 236786 [Multi-domain]  Cd Length: 328  Bit Score: 91.65  E-value: 1.54e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563   3 TTRRQFLKIAGLSVFGLGASTALDAADAVAKD-MPGAkyeVGgkhlaakrwaMVID-TRKLESREDYAriidACHKVhNV 80
Cdd:PRK10882   1 MNRRNFLKAASAGALLAGALPSVSHAAAENRPpIPGA---LG----------MLYDsTLCVGCQACVT----KCQEI-NF 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563  81 PSIPTKQEIKWIWTDKYD-------RVFTDDMSQHLSPAVREKDYL-LLCNHCENPPCVRVCPTKATFKRA-DGIVVMDY 151
Cdd:PRK10882  63 PERNPQGEQTWDNPDKLSpytnniiKVWKSGTGVNKDQEENGYAYIkKQCMHCVDPNCVSVCPVSALTKDPkTGIVHYDK 142

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 347520563 152 HRCIGCRFCMAGCPYGARSFNFGDPRPYlkevnpafptrmrgvVEKCTFCS----ERLEVGLLPACVEA-SNGAILFG 224
Cdd:PRK10882 143 DVCTGCRYCMVACPFNVPKYDYNNPFGA---------------IHKCELCNqkgvERLDKGGLPGCVEVcPTGAVIFG 205
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
120-225 5.05e-19

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 80.47  E-value: 5.05e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563 120 LLCNHCENPPCVRVCPTKAtFKRADGIVVMDYHRCIGCRFCMAGCPYGARSFNfgdprpylkevnpafPTRMRGVVEKCT 199
Cdd:COG1142   50 VQCRHCEDAPCAEVCPVGA-ITRDDGAVVVDEEKCIGCGLCVLACPFGAITMV---------------GEKSRAVAVKCD 113

                         90       100
                 ....*....|....*....|....*..
gi 347520563 200 FCSERLEvglLPACVEA-SNGAILFGD 225
Cdd:COG1142  114 LCGGREG---GPACVEAcPTGALRLVD 137
DMSOR_beta_like cd16368
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 53-224 8.08e-19

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319890 [Multi-domain]  Cd Length: 200  Bit Score: 81.70  E-value: 8.08e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563  53 AMVIDTRKLE--SREDYARIIDACHK--VHNVPSiPTKQEIKWIWTDKYDRVFTD--DMSQHLSP-------------AV 113
Cdd:cd16368    2 ATLIDLTKCDgcPGESIPACVRACREknQARFPE-PVSKPIQPYWPRKRIEDWSDkrDVTDRLTPynwlyvqkltvdtAG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563 114 REKDYLL--LCNHCENPPCVRVCPTKATFKRADGIVVMDYHRCIGCRFCMAGCPYG--ARSFNFGdprPYLKeVNPAFPT 189
Cdd:cd16368   81 GEKEVFIprRCMHCDNPPCAKLCPFGAARKTPEGAVYIDDDLCFGGAKCRDVCPWHipQRQAGVG---IYLH-LAPEYAG 156

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 347520563 190 rmRGVVEKCTFCSERLEVGLLPACVEA-SNGAILFG 224
Cdd:cd16368  157 --GGVMYKCDLCKDLLAQGKPPACIEAcPKGAQYFG 190
CooF_like cd10563
CooF, iron-sulfur subunit of carbon monoxide dehydrogenase; This family includes CooF, the ...
 113-224 4.51e-18

CooF, iron-sulfur subunit of carbon monoxide dehydrogenase; This family includes CooF, the iron-sulfur subunit of carbon monoxide dehydrogenase (CODH), found in anaerobic bacteria and archaea. Carbon monoxide dehydrogenase is a key enzyme for carbon monoxide (CO) metabolism, where CooF is the proposed mediator of electron transfer between CODH and the CO-induced hydrogenase, catalyzing the reaction that uses CO as a single carbon and energy source, and producing only H2 and CO2. The ion-sulfur subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons in the protein complex during reaction.


Pssm-ID: 319885 [Multi-domain]  Cd Length: 140  Bit Score: 78.07  E-value: 4.51e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563 113 VREKD---YLLLCNHCENPPCVRVCPTKATFK-RADGIVVMDYHRCIGCRFCMAGCPYGArsfnfgdprpylkevnpAFP 188
Cdd:cd10563   45 VEESGgrsFPLQCRHCDEPPCVKACMSGAMHKdPETGIVIHDEEKCVGCWMCVMVCPYGA-----------------IRP 107

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 347520563 189 TRMRGVVEKCTFCSERLEvgllPACVEA-SNGAILFG 224
Cdd:cd10563  108 DKERKVALKCDLCPDRET----PACVEAcPTGALVLE 140
DMSOR_beta_like cd10550
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 122-223 1.68e-17

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319872 [Multi-domain]  Cd Length: 130  Bit Score: 76.46  E-value: 1.68e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563 122 CNHCENPPCVRVCPTKA-TFKRADGIVVMDYHRCIGCRFCMAGCPYGARSFNfgdprpylkevnpafptRMRGVVEKCTF 200
Cdd:cd10550   49 CRQCEDAPCVEACPVGAiSRDEETGAVVVDEDKCIGCGMCVEACPFGAIRVD-----------------PETGKAIKCDL 111

                         90       100
                 ....*....|....*....|....
gi 347520563 201 CserlevGLLPACVEA-SNGAILF 223
Cdd:cd10550  112 C------GGDPACVKVcPTGALEF 129
PRK12769 PRK12769
putative oxidoreductase Fe-S binding subunit; Reviewed
 122-216 3.22e-16

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183733 [Multi-domain]  Cd Length: 654  Bit Score: 77.86  E-value: 3.22e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563 122 CNHCENPPCVRVCPTKATFKRADGIVVMDyHRCIGCRFCMAGCPYGARSFnfgdprpylkEVNPAFPTRMRGVVEKCTFC 201
Cdd:PRK12769  56 CHHCEDAPCARSCPNGAISHVDDSIQVNQ-QKCIGCKSCVVACPFGTMQI----------VLTPVAAGKVKATAHKCDLC 124

                         90
                 ....*....|....*
gi 347520563 202 SERlEVGllPACVEA 216
Cdd:PRK12769 125 AGR-ENG--PACVEN 136
DMSOR_beta_like cd16369
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 120-225 7.83e-16

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319891 [Multi-domain]  Cd Length: 172  Bit Score: 72.81  E-value: 7.83e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563 120 LLCNHCENPPCVRVCPTKATFKRADGIVVM-DYHRCIGCRFCMAGCPYGARSFNFGdprpylkevnpafptrmRGVVEKC 198
Cdd:cd16369   49 TVCMHCEDPTCAEVCPADAIKVTEDGVVQSaLKPRCIGCSNCVNACPFGVPKYDEE-----------------RNLMMKC 111

                         90       100
                 ....*....|....*....|....*...
gi 347520563 199 TFCSERLEVGLLPACVEA-SNGAILFGD 225
Cdd:cd16369  112 DMCYDRTSVGKAPMCASVcPSGALFYGT 139
PRK10330 PRK10330
electron transport protein HydN;
121-216 5.39e-12

electron transport protein HydN;


Pssm-ID: 182382 [Multi-domain]  Cd Length: 181  Bit Score: 62.60  E-value: 5.39e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563 121 LCNHCENPPCVRVCPTKAtFKRADGIVVMDYHRCIGCRFCMAGCPYGARSFNFgdpRPYLKEVNPAFPTRMRGV-VEKCT 199
Cdd:PRK10330  57 VCRQCEDAPCANVCPNGA-ISRDKGFVHVMQERCIGCKTCVVACPYGAMEVVV---RPVIRNSGAGLNVRAEKAeANKCD 132

                         90
                 ....*....|....*..
gi 347520563 200 FCSERlEVGllPACVEA 216
Cdd:PRK10330 133 LCNHR-EDG--PACMAA 146
DMSOR_beta_like cd16370
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 122-178 3.76e-11

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319892 [Multi-domain]  Cd Length: 131  Bit Score: 59.21  E-value: 3.76e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 347520563 122 CNHCENPPCVRVCPTKATFKRADGIVVMDYHRCIGCRFCMAGCPYGARSFNFGDPRP 178
Cdd:cd16370   53 CRACEDPPCAEACPTGALEPRKGGGVVLDKEKCIGCGNCVKACIVGAIFWDEETNKP 109
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
121-176 2.73e-10

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 55.12  E-value: 2.73e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 347520563 121 LCNHCENppCVRVCPTKAtFKRADGIVVMDYHRCIGCRFCMAGCPYGARSFNFGDP 176
Cdd:COG2768   12 KCIGCGA--CVKVCPVGA-ISIEDGKAVIDPEKCIGCGACIEVCPVGAIKIEWEED 64
PRK12809 PRK12809
putative oxidoreductase Fe-S binding subunit; Reviewed
 122-168 2.27e-09

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183762 [Multi-domain]  Cd Length: 639  Bit Score: 57.34  E-value: 2.27e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 347520563 122 CNHCENPPCVRVCPTKATFKRADGiVVMDYHRCIGCRFCMAGCPYGA 168
Cdd:PRK12809  56 CHHCNNAPCVTACPVNALTFQSDS-VQLDEQKCIGCKRCAIACPFGV 101
PRK09898 PRK09898
ferredoxin-like protein;
122-172 2.96e-09

ferredoxin-like protein;


Pssm-ID: 182135 [Multi-domain]  Cd Length: 208  Bit Score: 55.61  E-value: 2.96e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 347520563 122 CNHCENPPCVRVCPTKA-TFKRADGIVVMDYHRCIGCRFCMAGCPYGARSFN 172
Cdd:PRK09898 123 CRQCKEPQCMNVCPIGAiTWQQKEGCITVDHKRCIGCSACTTACPWMMATVN 174
W-FDH cd10559
tungsten-containing formate dehydrogenase, small subunit; This subfamily contains beta subunit ...
 122-228 8.08e-09

tungsten-containing formate dehydrogenase, small subunit; This subfamily contains beta subunit of Tungsten-containing formate dehydrogenase (W-FDH), a member of the DMSO reductase family. W-FDH contains a tungsten instead of molybdenum at the catalytic center. This enzyme seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It is a heterodimer of a large and a small subunit; the large subunit harbors the W site and one [4Fe-4S] center and the small subunit, containing three [4Fe-4S] clusters, functions to transfer electrons.


Pssm-ID: 319881 [Multi-domain]  Cd Length: 200  Bit Score: 53.98  E-value: 8.08e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563 122 CNHCENPPCVRVC---PTKATFKRADGIVVMDYHRCIGCRFCMA-GCPYGArsfnfgdPRpylkeVNPAfptrmRGVVEK 197
Cdd:cd10559   71 CRHCVTPPCKDAAdmvPGAVIQDEATGAVVFTEKTAELDFDDVLsACPYNI-------PR-----KNEA-----TGRIVK 133

                         90       100       110
                 ....*....|....*....|....*....|..
gi 347520563 198 CTFCSERLEVGLLPACVEA-SNGAILFGDLDD 228
Cdd:cd10559  134 CDMCIDRVSNGLQPACVKAcPTGAMNFGDRDE 165
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
122-170 1.83e-08

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 54.65  E-value: 1.83e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 347520563 122 CNHCEnpPCVRVCPTKAtFKRADGIVVMDYHRCIGCRFCMAGCPYGARS 170
Cdd:COG4624   93 CKNCY--PCVRACPVKA-IKVDDGKAEIDEEKCISCGQCVAVCPFGAIT 138
DMSOR_beta_like cd16367
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 122-216 4.72e-08

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319889 [Multi-domain]  Cd Length: 138  Bit Score: 50.77  E-value: 4.72e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563 122 CNHCENPPCVRVCPTKATFKRADGIVVMDyHRCIGCRFCMAGCPYGArsfnfgdprpylkevnpafpTRMRgVVEKCTFC 201
Cdd:cd16367   57 CRHCVDPVCMIGCPTGAIHRDDGGEVVIS-DACCGCGNCASACPYGA--------------------IQMV-RAVKCDLC 114

                         90
                 ....*....|....*
gi 347520563 202 SERLEvgllPACVEA 216
Cdd:cd16367  115 AGYAG----PACVSA 125
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 121-170 7.11e-08

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 48.51  E-value: 7.11e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 347520563 121 LCNHCENppCVRVCPTKAtFKRADGIVVMDYHRCIGCRFCMAGCPYGARS 170
Cdd:COG2221   16 KCIGCGL--CVAVCPTGA-ISLDDGKLVIDEEKCIGCGACIRVCPTGAIK 62
DMSOR_beta_like cd16372
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 122-179 1.23e-07

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319894 [Multi-domain]  Cd Length: 125  Bit Score: 49.26  E-value: 1.23e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 347520563 122 CNHCENppCVRVCPTKATFKRADGIVVMDYHRCIGCRFCMAGCPYGARSFNFGDPRPY 179
Cdd:cd16372   49 CNQCGE--CIDVCPTGAITRDANGVVMINKKLCVGCLMCVGFCPEGAMFKHEDYPEPF 104
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 122-168 2.36e-07

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 47.05  E-value: 2.36e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 347520563 122 CNHCENppCVRVCPTKA---TFKRADGIVVMDYHRCIGCRFCMAGCPYGA 168
Cdd:COG1143    4 CIGCGL--CVRVCPVDAitiEDGEPGKVYVIDPDKCIGCGLCVEVCPTGA 51
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 121-171 6.57e-07

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 45.87  E-value: 6.57e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 347520563 121 LCNHCENppCVRVCPTKATFKRADGIVVMDYHRCIGCRFCMAGCPYGARSF 171
Cdd:COG1149   12 KCIGCGL--CVEVCPEGAIKLDDGGAPVVDPDLCTGCGACVGVCPTGAITL 60
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 122-168 2.11e-06

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 43.67  E-value: 2.11e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 347520563  122 CNHCENppCVRVCPTKA------TFKRADGIVVMDYHRCIGCRFCMAGCPYGA 168
Cdd:pfam12838   1 CIGCGA--CVAACPVGAitldevGEKKGTKTVVIDPERCVGCGACVAVCPTGA 51
NapF COG1145
Ferredoxin [Energy production and conversion];
122-171 6.64e-06

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 46.25  E-value: 6.64e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 347520563 122 CNHCENppCVRVCPTKA-TFKRADGIVVMDYHRCIGCRFCMAGCPYGARSF 171
Cdd:COG1145  184 CIGCGL--CVKVCPTGAiRLKDGKPQIVVDPDKCIGCGACVKVCPVGAISL 232
FixX COG2440
Ferredoxin-like protein FixX [Energy production and conversion];
97-168 8.71e-06

Ferredoxin-like protein FixX [Energy production and conversion];


Pssm-ID: 441981 [Multi-domain]  Cd Length: 87  Bit Score: 42.88  E-value: 8.71e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 347520563  97 YDRVFTDDMSQHLspavREKDYLLLCNHCENPPCVRVCPTKATFKRADGIVVMDYHRCIGCRFCMAGCPYGA 168
Cdd:COG2440    3 LNNYNVDEDQPHI----KVKDPDICIARCLAKPCTRYCPAGVYEIVGDGRLQINYENCLECGTCRIKCPTQN 70
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
121-175 1.48e-05

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 45.62  E-value: 1.48e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 347520563 121 LCNHCENppCVRVCPTKATFKRADGIVVMDYHRCIGCRFCMAGCPYGARSF-NFGD 175
Cdd:COG1148  497 KCTGCGR--CVEVCPYGAISIDEKGVAEVNPALCKGCGTCAAACPSGAISLkGFTD 550
PRK12771 PRK12771
putative glutamate synthase (NADPH) small subunit; Provisional
 121-168 1.99e-05

putative glutamate synthase (NADPH) small subunit; Provisional


Pssm-ID: 237198 [Multi-domain]  Cd Length: 564  Bit Score: 45.25  E-value: 1.99e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 347520563 121 LCNHCENppCVRVCPTKATFK-RADGIVVMDYHRCIGCRFCMAGCPYGA 168
Cdd:PRK12771 511 NCFECDN--CYGACPQDAIIKlGPGRRYHFDYDKCTGCHICADVCPCGA 557
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 122-168 3.21e-05

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 41.18  E-value: 3.21e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 347520563 122 CNHCENppCVRVCPTKAtFKRADGIVVMDYHRCIGCRFCMAGCPYGA 168
Cdd:COG4231   24 CTGCGA--CVKVCPADA-IEEGDGKAVIDPDLCIGCGSCVQVCPVDA 67
vorD PRK09623
3-methyl-2-oxobutanoate dehydrogenase subunit delta;
130-168 8.27e-05

3-methyl-2-oxobutanoate dehydrogenase subunit delta;


Pssm-ID: 170016 [Multi-domain]  Cd Length: 105  Bit Score: 40.70  E-value: 8.27e-05
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 347520563 130 CVRVCPTKATFKRADGIVVMDYHRCIGCRFCMAGCPYGA 168
Cdd:PRK09623  59 CWKFCPEPAIYIKEDGYVAIDYDYCKGCGICANECPTKA 97
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 121-168 1.05e-04

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 39.69  E-value: 1.05e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 347520563 121 LCNHCEnpPCVRVCPTKAtFKRADGIVVMDYHR---CIGCRFCMAGCPYGA 168
Cdd:COG1146    9 KCIGCG--ACVEVCPVDV-LELDEEGKKALVINpeeCIGCGACELVCPVGA 56
PorD COG1144
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ...
 122-168 1.59e-04

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440759 [Multi-domain]  Cd Length: 84  Bit Score: 39.65  E-value: 1.59e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 347520563 122 CNHCENppCVRVCPTKATFKRADGIVVMDYHRCIGCRFCMAGCPYGA 168
Cdd:COG1144   32 CIGCGL--CWIVCPDGAIRVDDGKYYGIDYDYCKGCGICAEVCPVKA 76
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 130-168 1.86e-04

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 40.46  E-value: 1.86e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 347520563 130 CVRVCPTKATFKRADGIVVMDYHRCIGCRFCMAGCPYGA 168
Cdd:cd10549   86 CVKVCPVDAITLEDELEIVIDKEKCIGCGICAEVCPVNA 124
NapH COG0348
Polyferredoxin NapH [Energy production and conversion];
122-178 2.84e-04

Polyferredoxin NapH [Energy production and conversion];


Pssm-ID: 440117 [Multi-domain]  Cd Length: 263  Bit Score: 41.20  E-value: 2.84e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 347520563 122 CNHCENppCVRVCPTkatfkradGIVV----MDYHRCIGCRFCMAGCPYGARSFNFGDPRP 178
Cdd:COG0348  212 CIDCGL--CVKVCPM--------GIDIrkgeINQSECINCGRCIDACPKDAIRFSSRGEKT 262
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 122-168 3.10e-04

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 39.69  E-value: 3.10e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 347520563 122 CNHCENppCVRVCPTKA-TFKRADGIV---VMDYHRCIGCRFCMAGCPYGA 168
Cdd:cd10549    8 CIGCGI--CVKACPTDAiELGPNGAIArgpEIDEDKCVFCGACVEVCPTGA 56
Fer4_6 pfam12837
4Fe-4S binding domain; This superfamily includes proteins containing domains which bind to ...
 146-168 4.03e-04

4Fe-4S binding domain; This superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 432822 [Multi-domain]  Cd Length: 24  Bit Score: 36.82  E-value: 4.03e-04
                          10        20
                  ....*....|....*....|...
gi 347520563  146 IVVMDYHRCIGCRFCMAGCPYGA 168
Cdd:pfam12837   1 VVEVDPDKCIGCGRCVVVCPYGA 23
Fer4_10 pfam13237
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 121-165 6.03e-04

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 404174 [Multi-domain]  Cd Length: 56  Bit Score: 37.23  E-value: 6.03e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 347520563  121 LCNHCENppCVRVCPTKATFKRA------DGIVVMDYHRCIGCRFCMAGCP 165
Cdd:pfam13237   8 KCIGCGR--CTAACPAGLTRVGAiverleGEAVRIGVWKCIGCGACVEACP 56
PRK13795 PRK13795
hypothetical protein; Provisional
 130-165 6.78e-04

hypothetical protein; Provisional


Pssm-ID: 237510 [Multi-domain]  Cd Length: 636  Bit Score: 40.75  E-value: 6.78e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 347520563 130 CVRVCPTKA-TFKRADGIVVMDYHRCIGCRFCMAGCP 165
Cdd:PRK13795 589 CVGACPTGAiRIEEGKRKISVDEEKCIHCGKCTEVCP 625
porD PRK09625
pyruvate flavodoxin oxidoreductase subunit delta; Reviewed
 96-170 9.30e-04

pyruvate flavodoxin oxidoreductase subunit delta; Reviewed


Pssm-ID: 236596 [Multi-domain]  Cd Length: 133  Bit Score: 38.58  E-value: 9.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563  96 KYDRVFTDDMSQHLSPA-------VREKDyllLCNHCENppCVRVCPTKATFKRADGIVVMDYHRCIGCRFCMAGCPYGA 168
Cdd:PRK09625  31 NEERHYTEQSSFTTSVAhwrvekpVHNNE---ICINCFN--CWVYCPDAAILSRDKKLKGVDYSHCKGCGVCVEVCPTNP 105


                 ..
gi 347520563 169 RS 170
Cdd:PRK09625 106 KS 107
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 122-201 1.14e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 38.39  E-value: 1.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563 122 CNHCENPpCVRVCPTKA------TFKRAD-GIVVMDYHRCI------GCRFCMAGCPYGARSFnFGDPRPYLKEVNPafp 188
Cdd:cd16373   55 CDLCCDA-CVEVCPTGAlrpldlEEQKVKmGVAVIDKDRCLawqggtDCGVCVEACPTEAIAI-VLEDDVLRPVVDE--- 129

                         90
                 ....*....|...
gi 347520563 189 trmrgvvEKCTFC 201
Cdd:cd16373  130 -------DKCVGC 135
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
130-178 1.46e-03

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 39.15  E-value: 1.46e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 347520563 130 CVRVCPTKAtFKRADGIVVMDYHRCIGCRFCMAGCPYGA-RSFNFGDPRP 178
Cdd:PRK07118 221 CVKACPAGA-ITMENNLAVIDQEKCTSCGKCVEKCPTKAiRILNKPPKVK 269
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 111-164 3.28e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 37.23  E-value: 3.28e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 347520563 111 PAVREKDYLLLCNHCENppCVRVCPTKA--TFKRADGIV-----VMDYHRcIGCRFCMAGC 164
Cdd:cd16373    5 GALDEEEFLALCIRCGL--CVEACPTGViqPAGLEDGLEggrtpYLDPRE-GPCDLCCDAC 62
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 154-201 5.04e-03

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 34.42  E-value: 5.04e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 347520563  154 CIGCRFCMAGCPYGARSFNfgdprpylKEVNPAFPTRMRGVVEKCTFC 201
Cdd:pfam12838   1 CIGCGACVAACPVGAITLD--------EVGEKKGTKTVVIDPERCVGC 40
Fer4_10 pfam13237
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 146-216 5.89e-03

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 404174 [Multi-domain]  Cd Length: 56  Bit Score: 34.15  E-value: 5.89e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 347520563  146 IVVMDYHRCIGCRFCMAGCPYGARSFNFGDPRPYLKEVnpafptrmRGVVEKCTFCSerlevgllpACVEA 216
Cdd:pfam13237   1 KVVIDPDKCIGCGRCTAACPAGLTRVGAIVERLEGEAV--------RIGVWKCIGCG---------ACVEA 54
NapF COG1145
Ferredoxin [Energy production and conversion];
53-201 6.16e-03

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 37.01  E-value: 6.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563  53 AMVIDTRKLESREDYARIIDACHKVHNVPSIPTKQEIKWIWTDKYDRVFTDDMSQHLSPAVREKDYLLLCNHCENPPCVR 132
Cdd:COG1145   77 GAGEIVRVGIAAADLNLKAVALVLLLALAVAGAAKRLIISAVKLVAGLVVAAGEVLLVIAAALAEAGLAILGAAAPVDAL 156

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 347520563 133 VCPTKATFKRADGIV------VMDYHRCIGCRFCMAGCPYGARSFNFGDPRPylkEVNPafptrmrgvvEKCTFC 201
Cdd:COG1145  157 AISGGKKIEEELKIAikkakaVIDAEKCIGCGLCVKVCPTGAIRLKDGKPQI---VVDP----------DKCIGC 218
NapF_like cd10564
NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, ...
 111-168 6.69e-03

NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319886 [Multi-domain]  Cd Length: 139  Bit Score: 36.07  E-value: 6.69e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 347520563 111 PAVREKDYLLLCNHCEnpPCVRVCPTKATFKRADGIVVMDYHR--CIGCRFCMAGCPYGA 168
Cdd:cd10564    4 WAVDEALFLDLCTRCG--DCVEACPEGIIVRGDGGFPELDFSRgeCTFCGACAEACPEGA 61
RnfB COG2878
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and ...
 130-165 7.24e-03

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 442125 [Multi-domain]  Cd Length: 254  Bit Score: 36.90  E-value: 7.24e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 347520563 130 CVRVCPTKATFKRADGIVVMDYHRCIGCRFCMAGCP 165
Cdd:COG2878  145 CIKACPFDAIVGAAKGMHTVDEDKCTGCGLCVEACP 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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