NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|373523849|gb|EHP68769|]
View 

putative GTPase [Metallosphaera yellowstonensis MK1]

Protein Classification

GTPase domain-containing protein; ribosome small subunit-dependent GTPase A( domain architecture ID 10111509)

GTPase domain-containing protein, similar to human ADP-ribosylation factor 4, a GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit| ribosome small subunit-dependent GTPase A (RsgA) is a late-stage ribosome biogenesis factor involved in 30S subunit maturation

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MJ1464 cd01859
An uncharacterized, circularly permuted subfamily of the Ras GTPases; This family represents ...
 2-155 1.82e-85

An uncharacterized, circularly permuted subfamily of the Ras GTPases; This family represents archaeal GTPase typified by the protein MJ1464 from Methanococcus jannaschii. The members of this family show a circular permutation of the GTPase signature motifs so that C-terminal strands 5, 6, and 7 (strands 6 contain the NKxD motif) are relocated to the N terminus.


:

Pssm-ID: 206752 [Multi-domain]  Cd Length: 157  Bit Score: 251.47  E-value: 1.82e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849   2 LQLVKDVIRRADLIVEVLDAREPRLTRSRSMESLVERLGKPLLLVLNKGDLVPRGVLESWKRCFELEGHPTVYIAATQHM 81
Cdd:cd01859    2 KRLVRRIIKEADVVLEVVDARDPELTRSRKLERMALELGKKLIIVLNKADLVPREVLEKWKEVFESEGLPVVYVSARERL 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 373523849  82 GTKLLRTSIKE-AMRGRGGIVGFVGYPKTGKSSIINALKGRHSATTSPHPFSPGYTKSLQLFRIDSKLYAIDSPG 155
Cdd:cd01859   82 GTRILRRTIKElAIDGKPVIVGVVGYPKVGKSSIINALKGRHSASTSPIPGSPGYTKGIQLVRIDSKIYLIDTPG 156
 
Name Accession Description Interval E-value
MJ1464 cd01859
An uncharacterized, circularly permuted subfamily of the Ras GTPases; This family represents ...
 2-155 1.82e-85

An uncharacterized, circularly permuted subfamily of the Ras GTPases; This family represents archaeal GTPase typified by the protein MJ1464 from Methanococcus jannaschii. The members of this family show a circular permutation of the GTPase signature motifs so that C-terminal strands 5, 6, and 7 (strands 6 contain the NKxD motif) are relocated to the N terminus.


Pssm-ID: 206752 [Multi-domain]  Cd Length: 157  Bit Score: 251.47  E-value: 1.82e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849   2 LQLVKDVIRRADLIVEVLDAREPRLTRSRSMESLVERLGKPLLLVLNKGDLVPRGVLESWKRCFELEGHPTVYIAATQHM 81
Cdd:cd01859    2 KRLVRRIIKEADVVLEVVDARDPELTRSRKLERMALELGKKLIIVLNKADLVPREVLEKWKEVFESEGLPVVYVSARERL 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 373523849  82 GTKLLRTSIKE-AMRGRGGIVGFVGYPKTGKSSIINALKGRHSATTSPHPFSPGYTKSLQLFRIDSKLYAIDSPG 155
Cdd:cd01859   82 GTRILRRTIKElAIDGKPVIVGVVGYPKVGKSSIINALKGRHSASTSPIPGSPGYTKGIQLVRIDSKIYLIDTPG 156
RbgA COG1161
Ribosome biogenesis GTPase RbgA [Translation, ribosomal structure and biogenesis];
2-248 2.58e-44

Ribosome biogenesis GTPase RbgA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440775 [Multi-domain]  Cd Length: 279  Bit Score: 150.64  E-value: 2.58e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849   2 LQLVKDVIRRADLIVEVLDAREPRLTRSRSMESLVErlGKPLLLVLNKGDLVPRGVLESWKRCFELEGHPTVYIAATQHM 81
Cdd:COG1161   14 RRQIKEILKLVDLVIEVVDARIPLSSRNPMLDELVG--NKPRLLVLNKADLADPSVTKQWLKYFEKQGVDALAISAKKGK 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849  82 GTKLLRTSIKEAMRGRGGI-----VGFVGYPKTGKSSIINALKGRHSATTSPhpfSPGYTKSLQLFRIDSKLYAIDSPGL 156
Cdd:COG1161   92 GIKELIEAIRELAPEKGIKrrpirVMIVGIPNVGKSTLINRLAGKKVAKTGN---KPGVTKGQQWIKLDDGLELLDTPGI 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849 157 IPP------DGNPLerAIRGS-RPE--DLEDpvkVALALIERIEEFSRGSLGKVYKVDYTS--PLDLLEKIARKRGWIyR 225
Cdd:COG1161  169 LWPkfedpeVGYKL--AATGAiKDEvlDLEE---VALFLLGYLARRYPELLKERYKLDELPrtKLELLEAIGRKRGCL-L 242

                        250       260
                 ....*....|....*....|...
gi 373523849 226 SNGEPIVDQAAVQLIRDYHEGKI 248
Cdd:COG1161  243 SGGEVDLEKAAEILLTDFRSGKL 265
MMR_HSR1 pfam01926
50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete ...
 101-201 3.50e-12

50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.


Pssm-ID: 460387 [Multi-domain]  Cd Length: 113  Bit Score: 61.48  E-value: 3.50e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849  101 VGFVGYPKTGKSSIINALKGRHSATTSphpfSPGYTKSLQLFRI---DSKLYAIDSPGLIPPD--GNPLERAIRGSRPED 175
Cdd:pfam01926   2 VALVGRPNVGKSTLINALTGAKAIVSD----YPGTTRDPNEGRLelkGKQIILVDTPGLIEGAseGEGLGRAFLAIIEAD 77

                          90       100       110
                  ....*....|....*....|....*....|
gi 373523849  176 L----EDPVKVALALIERIEEFSRGSLGKV 201
Cdd:pfam01926  78 LilfvVDSEEGITPLDEELLELLRENKKPI 107
GTPase_YsxC TIGR03598
ribosome biogenesis GTP-binding protein YsxC/EngB; Members of this protein family are a GTPase ...
 101-155 5.95e-07

ribosome biogenesis GTP-binding protein YsxC/EngB; Members of this protein family are a GTPase associated with ribosome biogenesis, typified by YsxC from Bacillus subutilis. The family is widely but not universally distributed among bacteria. Members commonly are called EngB based on homology to EngA, one of several other GTPases of ribosome biogenesis. Cutoffs as set find essentially all bacterial members, but also identify large numbers of eukaryotic (probably organellar) sequences. This protein is found in about 80 percent of bacterial genomes. [Protein synthesis, Other]


Pssm-ID: 274670 [Multi-domain]  Cd Length: 179  Bit Score: 48.24  E-value: 5.95e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 373523849  101 VGFVGYPKTGKSSIINALKGRHS-ATTSPhpfSPGYTKSLQLFRIDSKLYAIDSPG 155
Cdd:TIGR03598  21 IAFAGRSNVGKSSLINALTNRKKlARTSK---TPGRTQLINFFEVNDGFRLVDLPG 73
trmE PRK05291
tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE;
6-100 1.20e-06

tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE;


Pssm-ID: 235392 [Multi-domain]  Cd Length: 449  Bit Score: 48.95  E-value: 1.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849   6 KDVIRRADLIVEVLDAREPRLTRSRsmESLVERLGKPLLLVLNKGDLVPRGVLEswkrcfELEGHPTVYIAATQHMGTKL 85
Cdd:PRK05291 289 REAIEEADLVLLVLDASEPLTEEDD--EILEELKDKPVIVVLNKADLTGEIDLE------EENGKPVIRISAKTGEGIDE 360

                         90
                 ....*....|....*
gi 373523849  86 LRTSIKEAMRGRGGI 100
Cdd:PRK05291 361 LREAIKELAFGGFGG 375
 
Name Accession Description Interval E-value
MJ1464 cd01859
An uncharacterized, circularly permuted subfamily of the Ras GTPases; This family represents ...
 2-155 1.82e-85

An uncharacterized, circularly permuted subfamily of the Ras GTPases; This family represents archaeal GTPase typified by the protein MJ1464 from Methanococcus jannaschii. The members of this family show a circular permutation of the GTPase signature motifs so that C-terminal strands 5, 6, and 7 (strands 6 contain the NKxD motif) are relocated to the N terminus.


Pssm-ID: 206752 [Multi-domain]  Cd Length: 157  Bit Score: 251.47  E-value: 1.82e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849   2 LQLVKDVIRRADLIVEVLDAREPRLTRSRSMESLVERLGKPLLLVLNKGDLVPRGVLESWKRCFELEGHPTVYIAATQHM 81
Cdd:cd01859    2 KRLVRRIIKEADVVLEVVDARDPELTRSRKLERMALELGKKLIIVLNKADLVPREVLEKWKEVFESEGLPVVYVSARERL 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 373523849  82 GTKLLRTSIKE-AMRGRGGIVGFVGYPKTGKSSIINALKGRHSATTSPHPFSPGYTKSLQLFRIDSKLYAIDSPG 155
Cdd:cd01859   82 GTRILRRTIKElAIDGKPVIVGVVGYPKVGKSSIINALKGRHSASTSPIPGSPGYTKGIQLVRIDSKIYLIDTPG 156
RbgA COG1161
Ribosome biogenesis GTPase RbgA [Translation, ribosomal structure and biogenesis];
2-248 2.58e-44

Ribosome biogenesis GTPase RbgA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440775 [Multi-domain]  Cd Length: 279  Bit Score: 150.64  E-value: 2.58e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849   2 LQLVKDVIRRADLIVEVLDAREPRLTRSRSMESLVErlGKPLLLVLNKGDLVPRGVLESWKRCFELEGHPTVYIAATQHM 81
Cdd:COG1161   14 RRQIKEILKLVDLVIEVVDARIPLSSRNPMLDELVG--NKPRLLVLNKADLADPSVTKQWLKYFEKQGVDALAISAKKGK 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849  82 GTKLLRTSIKEAMRGRGGI-----VGFVGYPKTGKSSIINALKGRHSATTSPhpfSPGYTKSLQLFRIDSKLYAIDSPGL 156
Cdd:COG1161   92 GIKELIEAIRELAPEKGIKrrpirVMIVGIPNVGKSTLINRLAGKKVAKTGN---KPGVTKGQQWIKLDDGLELLDTPGI 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849 157 IPP------DGNPLerAIRGS-RPE--DLEDpvkVALALIERIEEFSRGSLGKVYKVDYTS--PLDLLEKIARKRGWIyR 225
Cdd:COG1161  169 LWPkfedpeVGYKL--AATGAiKDEvlDLEE---VALFLLGYLARRYPELLKERYKLDELPrtKLELLEAIGRKRGCL-L 242

                        250       260
                 ....*....|....*....|...
gi 373523849 226 SNGEPIVDQAAVQLIRDYHEGKI 248
Cdd:COG1161  243 SGGEVDLEKAAEILLTDFRSGKL 265
Nucleostemin_like cd04178
A circularly permuted subfamily of the Ras GTPases; Nucleostemin (NS) is a nucleolar protein ...
 13-155 3.63e-35

A circularly permuted subfamily of the Ras GTPases; Nucleostemin (NS) is a nucleolar protein that functions as a regulator of cell growth and proliferation in stem cells and in several types of cancer cells, but is not expressed in the differentiated cells of most mammalian adult tissues. NS shuttles between the nucleolus and nucleoplasm bidirectionally at a rate that is fast and independent of cell type. Lowering GTP levels decreases the nucleolar retention of NS, and expression of NS is abruptly down-regulated during differentiation prior to terminal cell division. Found only in eukaryotes, NS consists of an N-terminal basic domain, a coiled-coil domain, a GTP-binding domain, an intermediate domain, and a C-terminal acidic domain. Experimental evidence indicates that NS uses its GTP-binding property as a molecular switch to control the transition between the nucleolus and nucleoplasm, and this process involves interaction between the basic, GTP-binding, and intermediate domains of the protein.


Pssm-ID: 206753 [Multi-domain]  Cd Length: 171  Bit Score: 123.84  E-value: 3.63e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849  13 DLIVEVLDAREPRLTRSRSMESLVERL--GKPLLLVLNKGDLVPRGVLESWKRCFELEgHPTV-YIAATQHMGTKLLRTS 89
Cdd:cd04178    1 DVILEVLDARDPLGCRCPQVERAVLVLgpNKKLVLVLNKIDLVPKENVEKWLKYLRNE-FPTVaFKASTQQQKKNLSRKS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849  90 IK-----EAMRGRGGI-----------------------VGFVGYPKTGKSSIINALKGRHSATTSPhpfSPGYTKSLQL 141
Cdd:cd04178   80 KKvkasdDLLSSSACLgadallkllknyarnkgiktsitVGVVGYPNVGKSSVINSLKRSRACNVGA---TPGVTKSMQE 156

                        170
                 ....*....|....
gi 373523849 142 FRIDSKLYAIDSPG 155
Cdd:cd04178  157 VHLDKHVKLLDSPG 170
HSR1_MMR1 cd01857
A circularly permuted subfamily of the Ras GTPases; Human HSR1 is localized to the human MHC ...
 8-159 1.65e-32

A circularly permuted subfamily of the Ras GTPases; Human HSR1 is localized to the human MHC class I region and is highly homologous to a putative GTP-binding protein, MMR1 from mouse. These proteins represent a new subfamily of GTP-binding proteins that has only eukaryote members. This subfamily shows a circular permutation of the GTPase signature motifs so that the C-terminal strands 5, 6, and 7 (strand 6 contains the G4 box with sequence NKXD) are relocated to the N-terminus.


Pssm-ID: 206750 [Multi-domain]  Cd Length: 140  Bit Score: 115.79  E-value: 1.65e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849   8 VIRRADLIVEVLDAREPRLTRSRSMESLVERLG--KPLLLVLNKGDLVPRGVLESWKRCFELEGHPTVYIAATqhmgtkl 85
Cdd:cd01857    8 VIERSDVVVQIVDARNPLFFRCPDLEKYVKEVDpsKENVLLLNKADLVTEEQRKAWARYFKKEGIVVLFFSAL------- 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 373523849  86 lrtsikeamrgRGGIVGFVGYPKTGKSSIINALKGRHSATTSPHpfsPGYTKSLQLFRIDSKLYAIDSPGLIPP 159
Cdd:cd01857   81 -----------NEATIGLVGYPNVGKSSLINALVGSKKVSVSST---PGKTKHFQTIFLEPGITLCDCPGLVFP 140
YlqF_related_GTPase cd01849
Circularly permuted YlqF-related GTPases; These proteins are found in bacteria, eukaryotes, ...
 13-156 3.61e-32

Circularly permuted YlqF-related GTPases; These proteins are found in bacteria, eukaryotes, and archaea. They all exhibit a circular permutation of the GTPase signature motifs so that the order of the conserved G box motifs is G4-G5-G1-G2-G3, with G4 and G5 being permuted from the C-terminal region of proteins in the Ras superfamily to the N-terminus of YlqF-related GTPases.


Pssm-ID: 206746 [Multi-domain]  Cd Length: 146  Bit Score: 115.17  E-value: 3.61e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849  13 DLIVEVLDAREPRLTRSRSMESLVERLGKPLLLVLNKGDLVPRGVLESWKRC-FELEGHPTVYIAATQHMGTKLLRTSIK 91
Cdd:cd01849    1 DVVVEVVDARDPLSSRNPDIEVLINEKNKKLIMVLNKADLVPKEVLRKWVAElSELYGTKTFFISATNGQGILKLKAEIT 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 373523849  92 EAMRGR----GGIVGFVGYPKTGKSSIINALKGRHSATTSPhpfSPGYTKSLQLFRIDSKLYAIDSPGL 156
Cdd:cd01849   81 KQKLKLkykkGIRVGVVGLPNVGKSSFINALLNKFKLKVGS---IPGTTKLQQDVKLDKEIYLYDTPGI 146
YlqF cd01856
Circularly permuted YlqF GTPase; Proteins of the YlqF family contain all sequence motifs ...
 2-155 4.28e-29

Circularly permuted YlqF GTPase; Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. The YlqF subfamily is represented in all eukaryotes as well as a phylogenetically diverse array of bacteria (including gram-positive bacteria, proteobacteria, Synechocystis, Borrelia, and Thermotoga).


Pssm-ID: 206749 [Multi-domain]  Cd Length: 171  Bit Score: 108.00  E-value: 4.28e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849   2 LQLVKDVIRRADLIVEVLDAREPRLTRSRSMESLVERlgKPLLLVLNKGDLVPRGVLESWKRCFELEGHPTVYIAATQHM 81
Cdd:cd01856   10 LRQIKEKLKLVDVVIEVRDARIPLSSRNPDLDKILGN--KPRLIVLNKADLADPAKTKKWLKYFKSQGEPVLFVNAKNGK 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849  82 GTKLLRTSIKEA-----------MRGRGGIVGFVGYPKTGKSSIINALKGRHSATTSPHpfsPGYTKSLQLFRIDSKLYA 150
Cdd:cd01856   88 GVKKLLKKAKKLlkeneklkakgLLPRPLRAMVVGIPNVGKSTLINRLRGKKVAKVGNK---PGVTRGQQWIRIGPNIEL 164


                 ....*
gi 373523849 151 IDSPG 155
Cdd:cd01856  165 LDTPG 169
NGP_1 cd01858
A novel nucleolar GTP-binding protein, circularly permuted subfamily of the Ras GTPases; ...
 8-155 1.46e-28

A novel nucleolar GTP-binding protein, circularly permuted subfamily of the Ras GTPases; Autoantigen NGP-1 (Nucleolar G-protein gene 1) has been shown to localize in the nucleolus and nucleolar organizers in all cell types analyzed, which is indicative of a function in ribosomal assembly. NGP-1 and its homologs show a circular permutation of the GTPase signature motifs so that the C-terminal strands 5, 6, and 7 (strand 6 contains the G4 box with NKXD motif) are relocated to the N terminus.


Pssm-ID: 206751 [Multi-domain]  Cd Length: 157  Bit Score: 106.23  E-value: 1.46e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849   8 VIRRADLIVEVLDAREPRLTRSRSMESLV--ERLGKPLLLVLNKGDLVPRGVLESWKRCFELEgHPTVYIAA--TQHMG- 82
Cdd:cd01858    5 VIDSSDVIIQVLDARDPMGTRCKHVEKYLrkEKPHKHLIFVLNKCDLVPTWVTKRWVKVLSKE-YPTLAFHAsiTNPFGk 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 373523849  83 ---TKLLRTSIKEAMRGRGGIVGFVGYPKTGKSSIINALKGRHSATTSPhpfSPGYTKSLQLFRIDSKLYAIDSPG 155
Cdd:cd01858   84 galINLLRQFAKLHSDKKQISVGFIGYPNVGKSSVINTLRSKKVCKVAP---IPGETKVWQYITLMKRIYLIDCPG 156
YqeH cd01855
Circularly permuted YqeH GTPase; YqeH is an essential GTP-binding protein. Depletion of YqeH ...
 2-156 2.11e-15

Circularly permuted YqeH GTPase; YqeH is an essential GTP-binding protein. Depletion of YqeH induces an excess initiation of DNA replication, suggesting that it negatively controls initiation of chromosome replication. The YqeH subfamily is common in eukaryotes and sporadically present in bacteria with probable acquisition by plants from chloroplasts. Proteins of the YqeH family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases.


Pssm-ID: 206748 [Multi-domain]  Cd Length: 191  Bit Score: 72.30  E-value: 2.11e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849   2 LQLVKDVIRRADLIVEVLDAREPRLTRSRSMESLVERlgKPLLLVLNKGDLVPRGV----LESW-KRCFELEGHP---TV 73
Cdd:cd01855   24 LEILSTLLNDNALVVHVVDIFDFPGSLIPGLAELIGA--KPVILVGNKIDLLPKDVkpnrLKQWvKKRLKIGGLKikdVI 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849  74 YIAATQHMGTKLLRTSIKEaMRGRGGIVGFVGYPKTGKSSIINAL----KGRH-------SATTSPHpfsPGYTKSLQLF 142
Cdd:cd01855  102 LVSAKKGWGVEELIEEIKK-LAKYRGDVYVVGATNVGKSTLINALlksnGGKVqaqalvqRLTVSPI---PGTTLGLIKI 177

                        170
                 ....*....|....
gi 373523849 143 RIDSKLYAIDSPGL 156
Cdd:cd01855  178 PLGEGKKLYDTPGI 191
MMR_HSR1 pfam01926
50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete ...
 101-201 3.50e-12

50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.


Pssm-ID: 460387 [Multi-domain]  Cd Length: 113  Bit Score: 61.48  E-value: 3.50e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849  101 VGFVGYPKTGKSSIINALKGRHSATTSphpfSPGYTKSLQLFRI---DSKLYAIDSPGLIPPD--GNPLERAIRGSRPED 175
Cdd:pfam01926   2 VALVGRPNVGKSTLINALTGAKAIVSD----YPGTTRDPNEGRLelkGKQIILVDTPGLIEGAseGEGLGRAFLAIIEAD 77

                          90       100       110
                  ....*....|....*....|....*....|
gi 373523849  176 L----EDPVKVALALIERIEEFSRGSLGKV 201
Cdd:pfam01926  78 LilfvVDSEEGITPLDEELLELLRENKKPI 107
YjeQ_EngC cd01854
Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; ...
 35-155 1.03e-10

Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; YjeQ (YloQ in Bacillus subtilis) is a ribosomal small subunit-dependent GTPase; hence also known as RsgA. YjeQ is a late-stage ribosomal biogenesis factor involved in the 30S subunit maturation, and it represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. All YjeQ family proteins display a unique domain architecture, which includes an N-terminal OB-fold RNA-binding domain, the central permuted GTPase domain, and a zinc knuckle-like C-terminal cysteine domain.


Pssm-ID: 206747 [Multi-domain]  Cd Length: 211  Bit Score: 59.72  E-value: 1.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849  35 LVERLGKPLLLVLNKGDLVPRGVLESWKRCFELEGHPTVYIAATQHMGTKLLRtsikEAMRGRggIVGFVGYPKTGKSSI 114
Cdd:cd01854   28 AAEASGIEPVIVLNKADLVDDEELEELLEIYEKLGYPVLAVSAKTGEGLDELR----ELLKGK--TSVLVGQSGVGKSTL 101

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 373523849 115 INAL----------------KGRHsaTTsphpfspgyTKSlQLFRIDSKLYAIDSPG 155
Cdd:cd01854  102 LNALlpelvlatgeiseklgRGRH--TT---------THR-ELFPLPGGGLIIDTPG 146
RsgA COG1162
Ribosome biogenesis GTPase RsgA [Translation, ribosomal structure and biogenesis];
44-155 1.51e-09

Ribosome biogenesis GTPase RsgA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440776 [Multi-domain]  Cd Length: 300  Bit Score: 57.05  E-value: 1.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849  44 LLVLNKGDLVPRGVLESWKRCFELEGHPTVYIAATQHMGTKLLRtsikEAMRGRggIVGFVGYPKTGKSSIINAL----- 118
Cdd:COG1162  118 VIVLNKADLADDEELEELLAIYEALGYPVLAVSAKTGEGLDELR----ELLKGK--TSVLVGQSGVGKSTLINALlpdad 191

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 373523849 119 -----------KGRHsaTTSphpfspgytkSLQLFRIDSKLYAIDSPG 155
Cdd:COG1162  192 latgeiseklgRGRH--TTT----------HAELYPLPGGGWLIDTPG 227
RsgA_GTPase pfam03193
RsgA GTPase; RsgA (also known as EngC and YjeQ) represents a protein family whose members are ...
 35-155 1.65e-09

RsgA GTPase; RsgA (also known as EngC and YjeQ) represents a protein family whose members are broadly conserved in bacteria and are indispensable for growth. The GTPase domain of RsgA is very similar to several P-loop GTPases, but differs in having a circular permutation of the GTPase structure described by a G4-G1-G3 pattern.


Pssm-ID: 427191 [Multi-domain]  Cd Length: 174  Bit Score: 55.63  E-value: 1.65e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849   35 LVERLGKPLLLVLNKGDLV-PRGVLESWKRCFELEGHPTVYIAATQHMGTKLLRTSIKeamrgrGGIVGFVGYPKTGKSS 113
Cdd:pfam03193  48 LAEASGIEPVIVLNKIDLLdEEEELEELLKIYRAIGYPVLFVSAKTGEGIEALKELLK------GKTTVLAGQSGVGKST 121

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 373523849  114 IINAL----------------KGRHSATTSphpfspgytkslQLFRIDSKLYAIDSPG 155
Cdd:pfam03193 122 LLNALlpeldlrtgeiseklgRGRHTTTHV------------ELFPLPGGGLLIDTPG 167
Era_like cd00880
E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family ...
 1-90 5.27e-09

E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngB), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. TrmE is ubiquitous in bacteria and is a widespread mitochondrial protein in eukaryotes, but is absent from archaea. The yeast member of TrmE family, MSS1, is involved in mitochondrial translation; bacterial members are often present in translation-related operons. FeoB represents an unusual adaptation of GTPases for high-affinity iron (II) transport. YihA (EngB) family of GTPases is typified by the E. coli YihA, which is an essential protein involved in cell division control. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain. EngA and its orthologs are composed of two GTPase domains and, since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family.


Pssm-ID: 206646 [Multi-domain]  Cd Length: 161  Bit Score: 53.79  E-value: 5.27e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849   1 MLQLVKDVIRRADLIVEVLDAREPRLTRSRSMESLVERlGKPLLLVLNKGDLVPRGVLESWKRCFELE---GHPTVYIAA 77
Cdd:cd00880   66 RVEEARQVADRADLVLLVVDSDLTPVEEEAKLGLLRER-GKPVLLVLNKIDLVPESEEEELLRERKLEllpDLPVIAVSA 144

                         90
                 ....*....|...
gi 373523849  78 TQHMGTKLLRTSI 90
Cdd:cd00880  145 LPGEGIDELRKKI 157
MnmE COG0486
tRNA U34 5-carboxymethylaminomethyl modifying GTPase MnmE/TrmE [Translation, ribosomal ...
 6-99 9.86e-09

tRNA U34 5-carboxymethylaminomethyl modifying GTPase MnmE/TrmE [Translation, ribosomal structure and biogenesis]; tRNA U34 5-carboxymethylaminomethyl modifying GTPase MnmE/TrmE is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440253 [Multi-domain]  Cd Length: 448  Bit Score: 55.07  E-value: 9.86e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849   6 KDVIRRADLIVEVLDAREPRltrSRSMESLVERL-GKPLLLVLNKGDLVPrgvlESWKRCFELEGHPTVYIAATQHMGTK 84
Cdd:COG0486  287 REAIEEADLVLLLLDASEPL---TEEDEEILEKLkDKPVIVVLNKIDLPS----EADGELKSLPGEPVIAISAKTGEGID 359

                         90
                 ....*....|....*
gi 373523849  85 LLRTSIKEAMRGRGG 99
Cdd:COG0486  360 ELKEAILELVGEGAL 374
Ras_like_GTPase cd00882
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
 2-90 1.60e-08

Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.


Pssm-ID: 206648 [Multi-domain]  Cd Length: 161  Bit Score: 52.46  E-value: 1.60e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849   2 LQLVKDVIRRADLIVEVLDAREPRLTRSRSMESLV--ERLGKPLLLVLNKGDLVPRGVLESWKRCFELE---GHPTVYIA 76
Cdd:cd00882   66 EELARLLLRGADLILLVVDSTDRESEEDAKLLILRrlRKEGIPIILVGNKIDLLEEREVEELLRLEELAkilGVPVFEVS 145

                         90
                 ....*....|....
gi 373523849  77 ATQHMGTKLLRTSI 90
Cdd:cd00882  146 AKTGEGVDELFEKL 159
YihA_EngB cd01876
YihA (EngB) GTPase family; The YihA (EngB) subfamily of GTPases is typified by the E. coli ...
 101-155 3.64e-08

YihA (EngB) GTPase family; The YihA (EngB) subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and consists of the GTPase domain only (some of the eukaryotic homologs contain an N-terminal extension of about 120 residues that might be involved in organellar targeting). Homologs of yihA are found in most Gram-positive and Gram-negative pathogenic bacteria, with the exception of Mycobacterium tuberculosis. The broad-spectrum nature of YihA and its essentiality for cell viability in bacteria make it an attractive antibacterial target.


Pssm-ID: 206665 [Multi-domain]  Cd Length: 170  Bit Score: 51.74  E-value: 3.64e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849 101 VGFVGYPKTGKSSIINALKGRH-----SATtsphpfsPGYTKSLQLFRIDSKLYAIDSPG 155
Cdd:cd01876    2 VAFAGRSNVGKSSLINALTNRKklartSKT-------PGRTQLINFFNVGDKFRLVDLPG 54
Era COG1159
GTPase Era, involved in 16S rRNA processing [Translation, ribosomal structure and biogenesis];
1-94 1.11e-07

GTPase Era, involved in 16S rRNA processing [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440773 [Multi-domain]  Cd Length: 290  Bit Score: 51.53  E-value: 1.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849   1 MLQLVKDVIRRADLIVEVLDAREPRLTRSRSMESLVERLGKPLLLVLNKGDLVPRGVL----ESWKRCFELEghPTVYIA 76
Cdd:COG1159   72 MNKAAWSALEDVDVILFVVDATEKIGEGDEFILELLKKLKTPVILVINKIDLVKKEELlpllAEYSELLDFA--EIVPIS 149

                         90
                 ....*....|....*...
gi 373523849  77 ATQHMGTKLLRTSIKEAM 94
Cdd:COG1159  150 ALKGDNVDELLDEIAKLL 167
Era cd04163
E. coli Ras-like protein (Era) is a multifunctional GTPase; Era (E. coli Ras-like protein) is ...
 1-92 4.98e-07

E. coli Ras-like protein (Era) is a multifunctional GTPase; Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit, possibly by chaperoning the 16S rRNA. It also contacts several assembly elements of the 30S subunit. Era couples cell growth with cytokinesis and plays a role in cell division and energy metabolism. Homologs have also been found in eukaryotes. Era contains two domains: the N-terminal GTPase domain and a C-terminal domain KH domain that is critical for RNA binding. Both domains are important for Era function. Era is functionally able to compensate for deletion of RbfA, a cold-shock adaptation protein that is required for efficient processing of the 16S rRNA.


Pssm-ID: 206726 [Multi-domain]  Cd Length: 168  Bit Score: 48.23  E-value: 4.98e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849   1 MLQLVKDVIRRADLIVEVLDAREPRLTRSRSMESLVERLGKPLLLVLNKGDLVPRGVLESWKRCFELEGHP---TVYIAA 77
Cdd:cd04163   72 MVKAAWSALKDVDLVLFVVDASEWIGEGDEFILELLKKSKTPVILVLNKIDLVKDKEDLLPLLEKLKELHPfaeIFPISA 151

                         90
                 ....*....|....*
gi 373523849  78 TQHMGTKLLRTSIKE 92
Cdd:cd04163  152 LKGENVDELLEYIVE 166
Gem1 COG1100
GTPase SAR1 family domain [General function prediction only];
3-98 5.19e-07

GTPase SAR1 family domain [General function prediction only];


Pssm-ID: 440717 [Multi-domain]  Cd Length: 177  Bit Score: 48.44  E-value: 5.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849   3 QLVKDVIRRADLIVEVLDAREPRLTRS-RSMESLVERLGK--PLLLVLNKGDLVPRGVLESWKR----CFELEGHPTVYI 75
Cdd:COG1100   71 QFYARQLTGASLYLFVVDGTREETLQSlYELLESLRRLGKksPIILVLNKIDLYDEEEIEDEERlkeaLSEDNIVEVVAT 150

                         90       100
                 ....*....|....*....|...
gi 373523849  76 AATQHMGTKLLRTSIKEAMRGRG 98
Cdd:COG1100  151 SAKTGEGVEELFAALAEILRGEG 173
GTPase_YsxC TIGR03598
ribosome biogenesis GTP-binding protein YsxC/EngB; Members of this protein family are a GTPase ...
 101-155 5.95e-07

ribosome biogenesis GTP-binding protein YsxC/EngB; Members of this protein family are a GTPase associated with ribosome biogenesis, typified by YsxC from Bacillus subutilis. The family is widely but not universally distributed among bacteria. Members commonly are called EngB based on homology to EngA, one of several other GTPases of ribosome biogenesis. Cutoffs as set find essentially all bacterial members, but also identify large numbers of eukaryotic (probably organellar) sequences. This protein is found in about 80 percent of bacterial genomes. [Protein synthesis, Other]


Pssm-ID: 274670 [Multi-domain]  Cd Length: 179  Bit Score: 48.24  E-value: 5.95e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 373523849  101 VGFVGYPKTGKSSIINALKGRHS-ATTSPhpfSPGYTKSLQLFRIDSKLYAIDSPG 155
Cdd:TIGR03598  21 IAFAGRSNVGKSSLINALTNRKKlARTSK---TPGRTQLINFFEVNDGFRLVDLPG 73
trmE PRK05291
tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE;
6-100 1.20e-06

tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE;


Pssm-ID: 235392 [Multi-domain]  Cd Length: 449  Bit Score: 48.95  E-value: 1.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849   6 KDVIRRADLIVEVLDAREPRLTRSRsmESLVERLGKPLLLVLNKGDLVPRGVLEswkrcfELEGHPTVYIAATQHMGTKL 85
Cdd:PRK05291 289 REAIEEADLVLLVLDASEPLTEEDD--EILEELKDKPVIVVLNKADLTGEIDLE------EENGKPVIRISAKTGEGIDE 360

                         90
                 ....*....|....*
gi 373523849  86 LRTSIKEAMRGRGGI 100
Cdd:PRK05291 361 LREAIKELAFGGFGG 375
trmE cd04164
trmE is a tRNA modification GTPase; TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in ...
 6-94 2.41e-06

trmE is a tRNA modification GTPase; TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase domain that forms a canonical Ras-like fold. It functions a molecular switch GTPase, and apparently uses a conformational change associated with GTP hydrolysis to promote the tRNA modification reaction, in which the conserved cysteine in the C-terminal domain is thought to function as a catalytic residue. In bacteria that are able to survive in extremely low pH conditions, TrmE regulates glutamate-dependent acid resistance.


Pssm-ID: 206727 [Multi-domain]  Cd Length: 159  Bit Score: 46.33  E-value: 2.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849   6 KDVIRRADLIVEVLDAREPRLTRSRSMESLVErlGKPLLLVLNKGDLVPRGVLESwkrcfELEGHPTVYIAATQHMGTKL 85
Cdd:cd04164   77 REAIEEADLVLLVVDASEGLDEEDLEILELPA--KKPVIVVLNKSDLLSDAEGIS-----ELNGKPIIAISAKTGEGIDE 149


                 ....*....
gi 373523849  86 LRTSIKEAM 94
Cdd:cd04164  150 LKEALLELA 158
HflX cd01878
HflX GTPase family; HflX subfamily. A distinct conserved domain with a glycine-rich segment ...
 9-94 2.64e-06

HflX GTPase family; HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual biological functions of these GTPases remain unclear. HflX is widespread, but not universally represented in all three superkingdoms.


Pssm-ID: 206666 [Multi-domain]  Cd Length: 204  Bit Score: 46.68  E-value: 2.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849   9 IRRADLIVEVLDAREP-RLTRSRSMESLVERLG---KPLLLVLNKGDLVPRGVLESWkrcFELEGHPTVYIAATQHMGTK 84
Cdd:cd01878  118 VAEADLLLHVVDASDPdREEQIETVEEVLKELGaddIPIILVLNKIDLLDDEELEER---LRAGRPDAVFISAKTGEGLD 194

                         90
                 ....*....|
gi 373523849  85 LLRTSIKEAM 94
Cdd:cd01878  195 LLKEAIEELL 204
PRK12289 PRK12289
small ribosomal subunit biogenesis GTPase RsgA;
37-174 3.44e-06

small ribosomal subunit biogenesis GTPase RsgA;


Pssm-ID: 237040 [Multi-domain]  Cd Length: 352  Bit Score: 47.32  E-value: 3.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849  37 ERLGKPLLLVLNKGDLVPRGVLESWKRCFELEGHPTVYIAATQHMGTKLLRTSIkeamrgRGGIVGFVGYPKTGKSSIIN 116
Cdd:PRK12289 117 ESTGLEIVLCLNKADLVSPTEQQQWQDRLQQWGYQPLFISVETGIGLEALLEQL------RNKITVVAGPSGVGKSSLIN 190

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 373523849 117 AL----------------KGRHSattsphpfspgyTKSLQLFRIDSKLYAIDSPGLIPPDGNPLERAIRGSRPE 174
Cdd:PRK12289 191 RLipdvelrvgkvsgklgRGRHT------------TRHVELFELPNGGLLADTPGFNQPDLDCSPRELAHYFPE 252
MnmE_helical pfam12631
MnmE helical domain; The tRNA modification GTPase MnmE consists of three domains. An ...
 6-99 4.41e-06

MnmE helical domain; The tRNA modification GTPase MnmE consists of three domains. An N-terminal domain, a helical domain and a GTPase domain which is nested within the helical domain. This family represents the helical domain.


Pssm-ID: 463649 [Multi-domain]  Cd Length: 326  Bit Score: 47.09  E-value: 4.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849    6 KDVIRRADLIVEVLDAREPrLTRSRSMESLVERLGKPLLLVLNKGDLVPRGVLESwkrcfELEGHPTVYIAATQHMGTKL 85
Cdd:pfam12631 168 REAIEEADLVLLVLDASRP-LDEEDLEILELLKDKKPIIVVLNKSDLLGEIDELE-----ELKGKPVLAISAKTGEGLDE 241

                          90
                  ....*....|....
gi 373523849   86 LRTSIKEAMRGRGG 99
Cdd:pfam12631 242 LEEAIKELFLAGEI 255
EngA2 cd01895
EngA2 GTPase contains the second domain of EngA; This EngA2 subfamily CD represents the second ...
 8-93 9.27e-06

EngA2 GTPase contains the second domain of EngA; This EngA2 subfamily CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family. Although the exact function of these proteins has not been elucidated, studies have revealed that the E. coli EngA homolog, Der, and Neisseria gonorrhoeae EngA are essential for cell viability. A recent report suggests that E. coli Der functions in ribosome assembly and stability.


Pssm-ID: 206682 [Multi-domain]  Cd Length: 174  Bit Score: 44.73  E-value: 9.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849   8 VIRRADLIVEVLDAREPRLTRSRSMESLVERLGKPLLLVLNKGDLVP--RGVLESWKRCFE-----LEGHPTVYIAATQH 80
Cdd:cd01895   81 AIERADVVLLVLDASEGITEQDLRIAGLILEEGKALIIVVNKWDLVEkdEKTMKEFEKELRrklpfLDYAPIVFISALTG 160

                         90
                 ....*....|...
gi 373523849  81 MGTKLLRTSIKEA 93
Cdd:cd01895  161 QGVDKLFDAIKEV 173
PRK12288 PRK12288
small ribosomal subunit biogenesis GTPase RsgA;
37-155 9.40e-06

small ribosomal subunit biogenesis GTPase RsgA;


Pssm-ID: 237039 [Multi-domain]  Cd Length: 347  Bit Score: 46.00  E-value: 9.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849  37 ERLGKPLLLVLNKGDLVP---RGVLESWKRCFELEGHPTVYIAATQHMGTKLLrtsiKEAMRGRGGIvgFVGYPKTGKSS 113
Cdd:PRK12288 147 ETLGIEPLIVLNKIDLLDdegRAFVNEQLDIYRNIGYRVLMVSSHTGEGLEEL----EAALTGRISI--FVGQSGVGKSS 220

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 373523849 114 IINAL----------------KGRHSATTSphpfspgytkslQLFRIDSKLYAIDSPG 155
Cdd:PRK12288 221 LINALlpeaeilvgdvsdnsgLGQHTTTAA------------RLYHFPHGGDLIDSPG 266
PRK00093 PRK00093
GTP-binding protein Der; Reviewed
 9-93 9.45e-06

GTP-binding protein Der; Reviewed


Pssm-ID: 234628 [Multi-domain]  Cd Length: 435  Bit Score: 46.20  E-value: 9.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849   9 IRRADLIVEVLDAREP------RLTrsrsmeSLVERLGKPLLLVLNKGDLVPRGVLESWKRCFE-----LEGHPTVYIAA 77
Cdd:PRK00093 253 IERADVVLLVIDATEGiteqdlRIA------GLALEAGRALVIVVNKWDLVDEKTMEEFKKELRrrlpfLDYAPIVFISA 326

                         90
                 ....*....|....*.
gi 373523849  78 TQHMGTKLLRTSIKEA 93
Cdd:PRK00093 327 LTGQGVDKLLEAIDEA 342
era PRK00089
GTPase Era; Reviewed
 1-94 1.06e-05

GTPase Era; Reviewed


Pssm-ID: 234624 [Multi-domain]  Cd Length: 292  Bit Score: 45.81  E-value: 1.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849   1 MLQLVKDVIRRADLIVEVLDAREPRLTRSRSMESLVERLGKPLLLVLNKGDLVPRG-----VLESWKRCFELEghPTVYI 75
Cdd:PRK00089  74 MNKAAWSSLKDVDLVLFVVDADEKIGPGDEFILEKLKKVKTPVILVLNKIDLVKDKeellpLLEELSELMDFA--EIVPI 151

                         90
                 ....*....|....*....
gi 373523849  76 AATQHMGTKLLRTSIKEAM 94
Cdd:PRK00089 152 SALKGDNVDELLDVIAKYL 170
PRK00098 PRK00098
GTPase RsgA; Reviewed
 35-156 1.84e-05

GTPase RsgA; Reviewed


Pssm-ID: 234631 [Multi-domain]  Cd Length: 298  Bit Score: 44.81  E-value: 1.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849  35 LVERLGKPLLLVLNKGDLVPRgvLESWKRCFELE---GHPTVYIAATQHMGTKLLrtsiKEAMRGRGGIvgFVGYPKTGK 111
Cdd:PRK00098 106 LAEANGIKPIIVLNKIDLLDD--LEEARELLALYraiGYDVLELSAKEGEGLDEL----KPLLAGKVTV--LAGQSGVGK 177

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 373523849 112 SSIINAL----------------KGRHSATTSphpfspgytkslQLFRIDSKLYAIDSPGL 156
Cdd:PRK00098 178 STLLNALapdlelktgeisealgRGKHTTTHV------------ELYDLPGGGLLIDTPGF 226
Der COG1160
Double Era-like domain GTPase Der [Translation, ribosomal structure and biogenesis];
9-118 1.85e-05

Double Era-like domain GTPase Der [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440774 [Multi-domain]  Cd Length: 438  Bit Score: 45.40  E-value: 1.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849   9 IRRADLIVEVLDAREPRLTRSRSMESLVERLGKPLLLVLNKGDLVPR--GVLESWKRCFeleGHPtVYIAATQHMGTKLL 86
Cdd:COG1160   80 IEEADVILFVVDGRAGLTPLDEEIAKLLRRSGKPVILVVNKVDGPKReaDAAEFYSLGL---GEP-IPISAEHGRGVGDL 155

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 373523849  87 RTSIKEAM-------RGRGGI-VGFVGYPKTGKSSIINAL 118
Cdd:COG1160  156 LDAVLELLpeeeeeeEEDDPIkIAIVGRPNVGKSSLINAL 195
PRK00093 PRK00093
GTP-binding protein Der; Reviewed
 9-118 2.12e-05

GTP-binding protein Der; Reviewed


Pssm-ID: 234628 [Multi-domain]  Cd Length: 435  Bit Score: 45.04  E-value: 2.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849   9 IRRADLIVEVLDAREPRLTRSRSMESLVERLGKPLLLVLNKGDLVPR--GVLESWKRCFeleGHPtVYIAATQHMGTKLL 86
Cdd:PRK00093  78 IEEADVILFVVDGRAGLTPADEEIAKILRKSNKPVILVVNKVDGPDEeaDAYEFYSLGL---GEP-YPISAEHGRGIGDL 153

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 373523849  87 RTSIKEAM-------RGRGGI-VGFVGYPKTGKSSIINAL 118
Cdd:PRK00093 154 LDAILEELpeeeeedEEDEPIkIAIIGRPNVGKSSLINAL 193
EngB COG0218
GTP-binding protein EngB required for normal cell division [Cell cycle control, cell division, ...
 101-155 6.05e-05

GTP-binding protein EngB required for normal cell division [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 439988 [Multi-domain]  Cd Length: 194  Bit Score: 42.75  E-value: 6.05e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 373523849 101 VGFVGYPKTGKSSIINALKGRHS-ATTSPhpfSPGYTKSLQLFRIDSKLYAIDSPG 155
Cdd:COG0218   26 IAFAGRSNVGKSSLINALTNRKKlARTSK---TPGKTQLINFFLINDKFYLVDLPG 78
MMR_HSR1 pfam01926
50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete ...
 9-49 7.94e-05

50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.


Pssm-ID: 460387 [Multi-domain]  Cd Length: 113  Bit Score: 41.07  E-value: 7.94e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 373523849    9 IRRADLIVEVLDAREPRLTRSRSMESLVERLGKPLLLVLNK 49
Cdd:pfam01926  73 IIEADLILFVVDSEEGITPLDEELLELLRENKKPIILVLNK 113
Der COG1160
Double Era-like domain GTPase Der [Translation, ribosomal structure and biogenesis];
9-93 1.67e-04

Double Era-like domain GTPase Der [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440774 [Multi-domain]  Cd Length: 438  Bit Score: 42.32  E-value: 1.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849   9 IRRADLIVEVLDAREP------RLTrsrsmeSLVERLGKPLLLVLNKGDLVP--RGVLESWKRCFE-----LEGHPTVYI 75
Cdd:COG1160  255 IERADVVLLVIDATEGiteqdlKIA------GLALEAGKALVIVVNKWDLVEkdRKTREELEKEIRrrlpfLDYAPIVFI 328

                         90
                 ....*....|....*...
gi 373523849  76 AATQHMGTKLLRTSIKEA 93
Cdd:COG1160  329 SALTGQGVDKLLEAVDEV 346
YeeP COG3596
Predicted GTPase [General function prediction only];
101-156 4.55e-04

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 40.90  E-value: 4.55e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 373523849 101 VGFVGYPKTGKSSIINALKGRHSATTS---PHpfspgyTKSLQLFRIDSK----LYAIDSPGL 156
Cdd:COG3596   42 IALVGKTGAGKSSLINALFGAEVAEVGvgrPC------TREIQRYRLESDglpgLVLLDTPGL 98
Era_like cd00880
E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family ...
 102-169 8.17e-04

E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngB), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. TrmE is ubiquitous in bacteria and is a widespread mitochondrial protein in eukaryotes, but is absent from archaea. The yeast member of TrmE family, MSS1, is involved in mitochondrial translation; bacterial members are often present in translation-related operons. FeoB represents an unusual adaptation of GTPases for high-affinity iron (II) transport. YihA (EngB) family of GTPases is typified by the E. coli YihA, which is an essential protein involved in cell division control. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain. EngA and its orthologs are composed of two GTPase domains and, since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family.


Pssm-ID: 206646 [Multi-domain]  Cd Length: 161  Bit Score: 39.15  E-value: 8.17e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 373523849 102 GFVGYPKTGKSSIINALKGRHSATTSPhpfSPGYTKSLQLFRI----DSKLYAIDSPGL--IPPDGNPLERAIR 169
Cdd:cd00880    1 AIFGRPNVGKSSLLNALLGQNVGIVSP---IPGTTRDPVRKEWellpLGPVVLIDTPGLdeEGGLGRERVEEAR 71
Toc34_like cd01853
Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like ...
 75-158 1.72e-03

Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like (Translocon at the Outer-envelope membrane of Chloroplasts) family contains several Toc proteins, including Toc34, Toc33, Toc120, Toc159, Toc86, Toc125, and Toc90. The Toc complex at the outer envelope membrane of chloroplasts is a molecular machine of ~500 kDa that contains a single Toc159 protein, four Toc75 molecules, and four or five copies of Toc34. Toc64 and Toc12 are associated with the translocon, but do not appear to be part of the core complex. The Toc translocon initiates the import of nuclear-encoded preproteins from the cytosol into the organelle. Toc34 and Toc159 are both GTPases, while Toc75 is a beta-barrel integral membrane protein. Toc159 is equally distributed between a soluble cytoplasmic form and a membrane-inserted form, suggesting that assembly of the Toc complex is dynamic. Toc34 and Toc75 act sequentially to mediate docking and insertion of Toc159 resulting in assembly of the functional translocon.


Pssm-ID: 206652  Cd Length: 248  Bit Score: 38.84  E-value: 1.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849  75 IAATQHMGTKLLRTSIKEAMR-------GRGGIvgfvgypktGKSSIINALKGRHSATTSphPFSPGYTKSLQLFRIDS- 146
Cdd:cd01853   10 PDATQTKLHELEAKLKKELDFsltilvlGKTGV---------GKSSTINSIFGERKVSVS--AFQSETLRPREVSRTVDg 78

                         90
                 ....*....|...
gi 373523849 147 -KLYAIDSPGLIP 158
Cdd:cd01853   79 fKLNIIDTPGLLE 91
Rbg1 COG1163
Ribosome-interacting GTPase RBG1 [Translation, ribosomal structure and biogenesis];
75-158 2.19e-03

Ribosome-interacting GTPase RBG1 [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440777 [Multi-domain]  Cd Length: 368  Bit Score: 39.01  E-value: 2.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849  75 IAATQ-HMGT----KLLRTSI--------KEAMRGRGGIVGF------------VGYPKTGKSSIINALKGRHSaTTSPH 129
Cdd:COG1163   15 ISKTPyNKATekhiGRLKAKLaelkeeleKRKKKSGGGGEGFavkksgdatvvlVGFPSVGKSTLLNKLTNAKS-EVGAY 93

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 373523849 130 PFS-----PGYTK----SLQLfridsklyaIDSPGLIP 158
Cdd:COG1163   94 EFTtldvvPGMLEykgaKIQI---------LDVPGLIE 122
NOG cd01897
Nucleolar GTP-binding protein (NOG); NOG1 is a nucleolar GTP-binding protein present in ...
 105-156 2.61e-03

Nucleolar GTP-binding protein (NOG); NOG1 is a nucleolar GTP-binding protein present in eukaryotes ranging from trypanosomes to humans. NOG1 is functionally linked to ribosome biogenesis and found in association with the nuclear pore complexes and identified in many preribosomal complexes. Thus, defects in NOG1 can lead to defects in 60S biogenesis. The S. cerevisiae NOG1 gene is essential for cell viability, and mutations in the predicted G motifs abrogate function. It is a member of the ODN family of GTP-binding proteins that also includes the bacterial Obg and DRG proteins.


Pssm-ID: 206684 [Multi-domain]  Cd Length: 167  Bit Score: 37.54  E-value: 2.61e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 373523849 105 GYPKTGKSSIINALKgRHSATTSPHPFSpgyTKSLQLFRIDSKLY---AIDSPGL 156
Cdd:cd01897    7 GYPNVGKSSLVNKLT-RAKPEVAPYPFT---TKSLFVGHFDYKYLrwqVIDTPGI 57
Ras_like_GTPase cd00882
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
 102-169 3.24e-03

Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.


Pssm-ID: 206648 [Multi-domain]  Cd Length: 161  Bit Score: 37.44  E-value: 3.24e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 373523849 102 GFVGYPKTGKSSIINALKGRHSATTSPHPFSpgyTKSLQLFR--IDSKLYAI---DSPGLIPPDGNPLERAIR 169
Cdd:cd00882    1 VVVGRGGVGKSSLLNALLGGEVGEVSDVPGT---TRDPDVYVkeLDKGKVKLvlvDTPGLDEFGGLGREELAR 70
TIGR00157 TIGR00157
ribosome small subunit-dependent GTPase A; Members of this protein were designated YjeQ and ...
 4-155 6.90e-03

ribosome small subunit-dependent GTPase A; Members of this protein were designated YjeQ and are now designated RsgA (ribosome small subunit-dependent GTPase A). The strongest motif in the alignment of these proteins is GXSGVGKS[ST], a classic P-loop for nucleotide binding. This protein has been shown to cleave GTP and remain bound to GDP. A role as a regulator of translation has been suggested. The Aquifex aeolicus ortholog is split into consecutive open reading frames. Consequently, this model was build in fragment mode (-f option). [Protein synthesis, Translation factors]


Pssm-ID: 272934 [Multi-domain]  Cd Length: 245  Bit Score: 37.01  E-value: 6.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849    4 LVKDVIRRADLIVEVLDAREPRLTRSRSMESLV--ERLGKPLLLVLNKGDLVprgvleswkrcfELEGHPTVYIAATQHM 81
Cdd:TIGR00157  29 LTRPIVANIDQIVIVSSAVLPELSLNQLDRFLVvaEAQNIEPIIVLNKIDLL------------DDEDMEKEQLDIYRNI 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373523849   82 GTKLLRTSIK---------EAMRGRGGIvgFVGYPKTGKSSIINALKGRHSATT----SPHPFSPGYTKSLQLFRIDSKL 148
Cdd:TIGR00157  97 GYQVLMTSSKnqdglkeliEALQNRISV--FAGQSGVGKSSLINALDPSVKQQVndisSKLGLGKHTTTHVELFHFHGGL 174


                  ....*..
gi 373523849  149 yAIDSPG 155
Cdd:TIGR00157 175 -IADTPG 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH