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Conserved domains on  [gi|394304946|gb|EJE48337|]
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deoxyadenosine/deoxycytidine kinase [Staphylococcus epidermidis NIH051475]

Protein Classification

deoxynucleoside kinase( domain architecture ID 10787652)

deoxynucleoside kinase catalyzes the phosphorylation of deoxyribonucleosides to yield the corresponding monophosphates

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Dck COG1428
Deoxyadenosine/deoxycytidine kinase [Nucleotide transport and metabolism];
7-212 2.64e-98

Deoxyadenosine/deoxycytidine kinase [Nucleotide transport and metabolism];


:

Pssm-ID: 441037 [Multi-domain]  Cd Length: 205  Bit Score: 284.37  E-value: 2.64e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394304946   7 PQNAVITIAGTVGVGKSTLTQALADKLNFKTSFENVDHNPYLDKFYHNFERWSFHLQIYFLAERFKEQKRMFEYGGGFVQ 86
Cdd:COG1428    1 MKPRYIAVEGNIGAGKTTLARLLAEHLGAELLLEPVEDNPFLEDFYEDPKRWAFPLQLFFLLSRFKQLKDLRQFGGNVVS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394304946  87 DRSIYEDVdIFAKMHEEQGTMSADDYHTYYELFNAmvMTPYFPKPDVLIYLECDYDEVIDRIQQRGRDMEINTDPEYWRK 166
Cdd:COG1428   81 DRSIYKDA-IFAKLLHEMGTLSDREFDLYRQLFDN--LTEDLPKPDLVIYLQASVDTLLERIKKRGRDYEQNIDLDYLER 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 394304946 167 LFKRYENWINNFNACPVVRLNINEYDIHEDLDSLDPVIDKIAQVIK 212
Cdd:COG1428  158 LNEAYEEWFEHYDASPVLIIDTDELDFVNNPEDLELLLEQIEEKLK 203
 
Name Accession Description Interval E-value
Dck COG1428
Deoxyadenosine/deoxycytidine kinase [Nucleotide transport and metabolism];
7-212 2.64e-98

Deoxyadenosine/deoxycytidine kinase [Nucleotide transport and metabolism];


Pssm-ID: 441037 [Multi-domain]  Cd Length: 205  Bit Score: 284.37  E-value: 2.64e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394304946   7 PQNAVITIAGTVGVGKSTLTQALADKLNFKTSFENVDHNPYLDKFYHNFERWSFHLQIYFLAERFKEQKRMFEYGGGFVQ 86
Cdd:COG1428    1 MKPRYIAVEGNIGAGKTTLARLLAEHLGAELLLEPVEDNPFLEDFYEDPKRWAFPLQLFFLLSRFKQLKDLRQFGGNVVS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394304946  87 DRSIYEDVdIFAKMHEEQGTMSADDYHTYYELFNAmvMTPYFPKPDVLIYLECDYDEVIDRIQQRGRDMEINTDPEYWRK 166
Cdd:COG1428   81 DRSIYKDA-IFAKLLHEMGTLSDREFDLYRQLFDN--LTEDLPKPDLVIYLQASVDTLLERIKKRGRDYEQNIDLDYLER 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 394304946 167 LFKRYENWINNFNACPVVRLNINEYDIHEDLDSLDPVIDKIAQVIK 212
Cdd:COG1428  158 LNEAYEEWFEHYDASPVLIIDTDELDFVNNPEDLELLLEQIEEKLK 203
dNK pfam01712
Deoxynucleoside kinase; This family consists of various deoxynucleoside kinases cytidine EC:2. ...
 12-212 9.63e-73

Deoxynucleoside kinase; This family consists of various deoxynucleoside kinases cytidine EC:2.7.1.74, guanosine EC:2.7.1.113, adenosine EC:2.7.1.76 and thymidine kinase EC:2.7.1.21 (which also phosphorylates deoxyuridine and deoxycytosine.) These enzymes catalyze the production of deoxynucleotide 5'-monophosphate from a deoxynucleoside. Using ATP and yielding ADP in the process.


Pssm-ID: 396326  Cd Length: 201  Bit Score: 219.50  E-value: 9.63e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394304946   12 ITIAGTVGVGKSTLTQALADKLNFKTSFENVDH--NPYLDKFYHNFERWSFHLQIYFLAERFKEQKRMFEYGGGFVQDRS 89
Cdd:pfam01712   1 ISIEGNIGAGKSTLTKILSKRLGFKVFEEPVDRwtNPYLDKFYKDPSRWSFALQTYFLNSRFKQQLEAFFTGQVVILERS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394304946   90 IYEDVDIFAKMHEEQGTMSADDYHTYYELFNAmvMTPYFPKPDVLIYLECDYDEVIDRIQQRGRDMEINTDPEYWRKLFK 169
Cdd:pfam01712  81 IYSDRYIFAKMLYDKGTMSDEEYKTYKDLYDN--MLLEFPKPDLIIYLKTSPETCLERIKKRGRTEEQNISLDYLERLHE 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 394304946  170 RYENWINNFNACPVVRLNINEYDIHEDLDSLDPVIDKIAQVIK 212
Cdd:pfam01712 159 KYEAWLKKLNLSPVLVIDGDELDFVFFEEDREDVMNEVNEFVS 201
dNK cd01673
Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to ...
 11-193 3.12e-60

Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1.113), adenosine (EC 2.7.1.76), and thymidine (EC 2.7.1.21) kinases. They are key enzymes in the salvage of deoxyribonucleosides originating from extra- or intracellular breakdown of DNA.


Pssm-ID: 238836  Cd Length: 193  Bit Score: 187.05  E-value: 3.12e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394304946  11 VITIAGTVGVGKSTLTQALADKLNFKTSFE----NVDHNPYLDKFYHNFERWSFHLQIYFLAERFKEQKRMFEY---GGG 83
Cdd:cd01673    1 VIVVEGNIGAGKSTLAKELAEHLGYEVVPEpvepDVEGNPFLEKFYEDPKRWAFPFQLYFLLSRLKQYKDALEHlstGQG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394304946  84 FVQDRSIYEDVDIFAKMHEEQGTMSADdYHTYYELFNAMVmtPYFPKPDVLIYLECDYDEVIDRIQQRGRDMEINTDPEY 163
Cdd:cd01673   81 VILERSIFSDRVFAEANLKEGGIMKTE-YDLYNELFDNLI--PELLPPDLVIYLDASPETCLKRIKKRGRPEEQGIPLDY 157

                        170       180       190
                 ....*....|....*....|....*....|..
gi 394304946 164 WRKLFKRYENW--INNFNACPVVRLNINEYDI 193
Cdd:cd01673  158 LEDLHEAYEKWflPQMYEKAPVLIIDANEADI 189
 
Name Accession Description Interval E-value
Dck COG1428
Deoxyadenosine/deoxycytidine kinase [Nucleotide transport and metabolism];
7-212 2.64e-98

Deoxyadenosine/deoxycytidine kinase [Nucleotide transport and metabolism];


Pssm-ID: 441037 [Multi-domain]  Cd Length: 205  Bit Score: 284.37  E-value: 2.64e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394304946   7 PQNAVITIAGTVGVGKSTLTQALADKLNFKTSFENVDHNPYLDKFYHNFERWSFHLQIYFLAERFKEQKRMFEYGGGFVQ 86
Cdd:COG1428    1 MKPRYIAVEGNIGAGKTTLARLLAEHLGAELLLEPVEDNPFLEDFYEDPKRWAFPLQLFFLLSRFKQLKDLRQFGGNVVS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394304946  87 DRSIYEDVdIFAKMHEEQGTMSADDYHTYYELFNAmvMTPYFPKPDVLIYLECDYDEVIDRIQQRGRDMEINTDPEYWRK 166
Cdd:COG1428   81 DRSIYKDA-IFAKLLHEMGTLSDREFDLYRQLFDN--LTEDLPKPDLVIYLQASVDTLLERIKKRGRDYEQNIDLDYLER 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 394304946 167 LFKRYENWINNFNACPVVRLNINEYDIHEDLDSLDPVIDKIAQVIK 212
Cdd:COG1428  158 LNEAYEEWFEHYDASPVLIIDTDELDFVNNPEDLELLLEQIEEKLK 203
dNK pfam01712
Deoxynucleoside kinase; This family consists of various deoxynucleoside kinases cytidine EC:2. ...
 12-212 9.63e-73

Deoxynucleoside kinase; This family consists of various deoxynucleoside kinases cytidine EC:2.7.1.74, guanosine EC:2.7.1.113, adenosine EC:2.7.1.76 and thymidine kinase EC:2.7.1.21 (which also phosphorylates deoxyuridine and deoxycytosine.) These enzymes catalyze the production of deoxynucleotide 5'-monophosphate from a deoxynucleoside. Using ATP and yielding ADP in the process.


Pssm-ID: 396326  Cd Length: 201  Bit Score: 219.50  E-value: 9.63e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394304946   12 ITIAGTVGVGKSTLTQALADKLNFKTSFENVDH--NPYLDKFYHNFERWSFHLQIYFLAERFKEQKRMFEYGGGFVQDRS 89
Cdd:pfam01712   1 ISIEGNIGAGKSTLTKILSKRLGFKVFEEPVDRwtNPYLDKFYKDPSRWSFALQTYFLNSRFKQQLEAFFTGQVVILERS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394304946   90 IYEDVDIFAKMHEEQGTMSADDYHTYYELFNAmvMTPYFPKPDVLIYLECDYDEVIDRIQQRGRDMEINTDPEYWRKLFK 169
Cdd:pfam01712  81 IYSDRYIFAKMLYDKGTMSDEEYKTYKDLYDN--MLLEFPKPDLIIYLKTSPETCLERIKKRGRTEEQNISLDYLERLHE 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 394304946  170 RYENWINNFNACPVVRLNINEYDIHEDLDSLDPVIDKIAQVIK 212
Cdd:pfam01712 159 KYEAWLKKLNLSPVLVIDGDELDFVFFEEDREDVMNEVNEFVS 201
dNK cd01673
Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to ...
 11-193 3.12e-60

Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1.113), adenosine (EC 2.7.1.76), and thymidine (EC 2.7.1.21) kinases. They are key enzymes in the salvage of deoxyribonucleosides originating from extra- or intracellular breakdown of DNA.


Pssm-ID: 238836  Cd Length: 193  Bit Score: 187.05  E-value: 3.12e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394304946  11 VITIAGTVGVGKSTLTQALADKLNFKTSFE----NVDHNPYLDKFYHNFERWSFHLQIYFLAERFKEQKRMFEY---GGG 83
Cdd:cd01673    1 VIVVEGNIGAGKSTLAKELAEHLGYEVVPEpvepDVEGNPFLEKFYEDPKRWAFPFQLYFLLSRLKQYKDALEHlstGQG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394304946  84 FVQDRSIYEDVDIFAKMHEEQGTMSADdYHTYYELFNAMVmtPYFPKPDVLIYLECDYDEVIDRIQQRGRDMEINTDPEY 163
Cdd:cd01673   81 VILERSIFSDRVFAEANLKEGGIMKTE-YDLYNELFDNLI--PELLPPDLVIYLDASPETCLKRIKKRGRPEEQGIPLDY 157

                        170       180       190
                 ....*....|....*....|....*....|..
gi 394304946 164 WRKLFKRYENW--INNFNACPVVRLNINEYDI 193
Cdd:cd01673  158 LEDLHEAYEKWflPQMYEKAPVLIIDANEADI 189
NDUO42 cd02030
NADH:Ubiquinone oxioreductase, 42 kDa (NDUO42) is a family of proteins that are highly similar ...
 11-173 2.28e-14

NADH:Ubiquinone oxioreductase, 42 kDa (NDUO42) is a family of proteins that are highly similar to deoxyribonucleoside kinases (dNK). Members of this family have been identified as one of the subunits of NADH:Ubiquinone oxioreductase (complex I), a multi-protein complex located in the inner mitochondrial membrane. The main function of the complex is to transport electrons from NADH to ubiquinone, which is accompanied by the translocation of protons from the mitochondrial matrix to the inter membrane space.


Pssm-ID: 238988  Cd Length: 219  Bit Score: 69.31  E-value: 2.28e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394304946  11 VITIAGTVGVGKSTLTQALADKLNFKTSFENVDH------------------NPYLDKFY---HNFERWSFHLQIYFLAE 69
Cdd:cd02030    1 VITVDGNIASGKGKLAKELAEKLGMKYFPEAGIHyldsttgdgkpldpafngNCSLEKFYddpKSNDGNSYRLQSWMYSS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394304946  70 RFKEQKRMFEY----GGGFVQDRSIYEDVdIFAKMHEEQGTMSADDYHTYYELFNAMVmtPYFPKPDVLIYLECDYDEVI 145
Cdd:cd02030   81 RLLQYSDALEHllstGQGVVLERSPFSDF-VFLEAMYKQGYIRKQCVDHYNEVKGNTI--PELLPPHLVIYLDVPVPEVQ 157

                        170       180
                 ....*....|....*....|....*...
gi 394304946 146 DRIQQRGRDMEINTDPEYWRKLFKRYEN 173
Cdd:cd02030  158 KRIKKRGDPHEMKVTSAYLQDIENAYKK 185
AAA_18 pfam13238
AAA domain;
12-165 2.69e-07

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 47.81  E-value: 2.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394304946   12 ITIAGTVGVGKSTLTQALADKLNFktsfenvdHNPYLDKFYHNFERWSFhlqiyflAERFKEQKRMFEYGGGFVQDRSIY 91
Cdd:pfam13238   1 ILITGTPGVGKTTLAKELSKRLGF--------GDNVRDLALENGLVLGD-------DPETRESKRLDEDKLDRLLDLLEE 65

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 394304946   92 EDVdifakmhEEQGTMSADDYHTYYELfnamvmtPYFPKPDVLIYLECDYDEVIDRIQQRG---RDMEINTDPEYWR 165
Cdd:pfam13238  66 NAA-------LEEGGNLIIDGHLAELE-------PERAKDLVGIVLRASPEELLERLEKRGyeeAKIKENEEAEILG 128
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 11-36 1.36e-04

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 40.55  E-value: 1.36e-04
                         10        20
                 ....*....|....*....|....*.
gi 394304946  11 VITIAGTVGVGKSTLTQALADKLNFK 36
Cdd:cd02020    1 IIAIDGPAGSGKSTVAKLLAKKLGLP 26
Cmk COG0283
Cytidylate kinase [Nucleotide transport and metabolism];
11-49 1.76e-04

Cytidylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 440052 [Multi-domain]  Cd Length: 220  Bit Score: 41.16  E-value: 1.76e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 394304946  11 VITIAGTVGVGKSTLTQALADKLNFKtsfenvdhnpYLD 49
Cdd:COG0283    2 VIAIDGPAGSGKSTVAKALAKRLGYH----------YLD 30
Pgk2 COG2074
2-phosphoglycerate kinase/Mevalonate-3-phosphate 5-kinase [Carbohydrate transport and ...
 11-36 1.06e-03

2-phosphoglycerate kinase/Mevalonate-3-phosphate 5-kinase [Carbohydrate transport and metabolism, Lipid transport and metabolism];


Pssm-ID: 441677  Cd Length: 207  Bit Score: 38.78  E-value: 1.06e-03
                         10        20
                 ....*....|....*....|....*.
gi 394304946  11 VITIAGTVGVGKSTLTQALADKLNFK 36
Cdd:COG2074    8 IILIGGASGVGKSTIAAELARRLGIP 33
TMPK cd01672
Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the ...
 128-213 1.57e-03

Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step in either de novo or salvage biosynthesis of thymidine triphosphate (TTP).


Pssm-ID: 238835  Cd Length: 200  Bit Score: 38.40  E-value: 1.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394304946 128 FPKPDVLIYLECDYDEVIDRIQQRGRDMEINTDP-EYWRKLFKRYENWINNFNAcPVVRLNINeydihedlDSLDPVIDK 206
Cdd:cd01672  123 GLKPDLTILLDIDPEVGLARIEARGRDDRDEQEGlEFHERVREGYLELAAQEPE-RIIVIDAS--------QPLEEVLAE 193


                 ....*..
gi 394304946 207 IAQVIKA 213
Cdd:cd01672  194 ILKAILE 200
Fap7 COG1936
Broad-specificity NMP kinase [Nucleotide transport and metabolism];
11-36 2.31e-03

Broad-specificity NMP kinase [Nucleotide transport and metabolism];


Pssm-ID: 441539 [Multi-domain]  Cd Length: 173  Bit Score: 37.49  E-value: 2.31e-03
                         10        20
                 ....*....|....*....|....*.
gi 394304946  11 VITIAGTVGVGKSTLTQALADKLNFK 36
Cdd:COG1936    2 RIAITGTPGTGKTTVAKLLAERLGLE 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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