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Conserved domains on  [gi|395549008|gb|EJG16161|]
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UbiC transcription regulator-associated domain protein [Actinomyces sp. ICM47]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11450764)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain

Gene Ontology:  GO:0003677|GO:0003700
PubMed:  2060763|26172911|33509775|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
22-252 1.38e-74

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 226.67  E-value: 1.38e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395549008  22 SSPVPLYFQISEPIAELINTGALPADTRLEDELSMAARLRVSRPTARQALQRLVDRGLLTRRRGVGTIVSPSQVHRPL-E 100
Cdd:COG2188    1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLsR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395549008 101 LTSLMKDLVEAGHKVQTTIQRYEAHPATEAEAEALKIEAGTLIVHIERTRFTNNEPIAVLTNLIPADIAP--TMQELESG 178
Cdd:COG2188   81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPglLEEDLETG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 395549008 179 SLYDLMRER-GVTLTSARQVIGARTATTKEAKLLSEHRGAALLTTQRTTYDPSGRIVEYGDHIYRASRYSFEANL 252
Cdd:COG2188  161 SLYELLEERyGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVEL 235
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
22-252 1.38e-74

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 226.67  E-value: 1.38e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395549008  22 SSPVPLYFQISEPIAELINTGALPADTRLEDELSMAARLRVSRPTARQALQRLVDRGLLTRRRGVGTIVSPSQVHRPL-E 100
Cdd:COG2188    1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLsR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395549008 101 LTSLMKDLVEAGHKVQTTIQRYEAHPATEAEAEALKIEAGTLIVHIERTRFTNNEPIAVLTNLIPADIAP--TMQELESG 178
Cdd:COG2188   81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPglLEEDLETG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 395549008 179 SLYDLMRER-GVTLTSARQVIGARTATTKEAKLLSEHRGAALLTTQRTTYDPSGRIVEYGDHIYRASRYSFEANL 252
Cdd:COG2188  161 SLYELLEERyGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVEL 235
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 110-247 1.22e-36

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 126.56  E-value: 1.22e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395549008  110 EAGHKVQTTIQRYEAHPATEAEAEALKIEAGTLIVHIERTRFTNNEPIAVLTNLIPADIAP--TMQELESGSLYDLMRER 187
Cdd:pfam07702   1 AQGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPdlLEEDLEEGSLYDYLEER 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 395549008  188 -GVTLTSARQVIGARTATTKEAKLLSEHRGAALLTTQRTTYDPSGRIVEYGDHIYRASRYS 247
Cdd:pfam07702  81 yGLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 110-247 1.05e-32

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 116.24  E-value: 1.05e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395549008   110 EAGHKVQTTIQRYEAHPATEAEAEALKIEAGTLIVHIERTRFTNNEPIAVLTNLIPADIAPTM-QELESGSLYDLMRER- 187
Cdd:smart00866   1 AQGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLlEEDLSGSLYEYLEERl 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 395549008   188 ---GVTLTSARQVIGARTATTKEAKLLSEHRGAALLTTQRTTYDPSGRIVEYGDHIYRASRYS 247
Cdd:smart00866  81 glkIVRSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
PRK11402 PRK11402
transcriptional regulator PhoB;
19-251 3.98e-27

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 104.92  E-value: 3.98e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395549008  19 LDRSSPVPLYFQISEPIAELINTGALPADTRLEDELSMAARLRVSRPTARQALQRLVDRGLLTRRRGVGTIVSPSQVHRP 98
Cdd:PRK11402   2 TDRYSHQLLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVENA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395549008  99 LELTSLMKD-LVEAGHKVQTTIQRYEaHPATEAEAEALKIEAGTLIVHIERTRFTNNEPIAVLTNLIPADIAPTMQEL-- 175
Cdd:PRK11402  82 LLTVSGFTDfGVSQGKATKEKVIEQE-RVSAAPFCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDFDEIyv 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 395549008 176 ESGSLYDLMRER-GVTLTSARQVIGARTATTKEAKLLSEHRGAALLTTQRTTYDPSGRIVEYGDHIYRASRYSFEAN 251
Cdd:PRK11402 161 EGSSTYQLFQERfDTRVVSDKKTIDIFAATRPEAKWLKCELGEPLFRISKIAFDQNDKPVHVSELFCRANRVTLTID 237
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 26-91 4.05e-17

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 73.25  E-value: 4.05e-17
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 395549008  26 PLYFQISEPIAELINTGALPADTRLEDELSMAARLRVSRPTARQALQRLVDRGLLTRRRGVGTIVS 91
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
22-252 1.38e-74

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 226.67  E-value: 1.38e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395549008  22 SSPVPLYFQISEPIAELINTGALPADTRLEDELSMAARLRVSRPTARQALQRLVDRGLLTRRRGVGTIVSPSQVHRPL-E 100
Cdd:COG2188    1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLsR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395549008 101 LTSLMKDLVEAGHKVQTTIQRYEAHPATEAEAEALKIEAGTLIVHIERTRFTNNEPIAVLTNLIPADIAP--TMQELESG 178
Cdd:COG2188   81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPglLEEDLETG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 395549008 179 SLYDLMRER-GVTLTSARQVIGARTATTKEAKLLSEHRGAALLTTQRTTYDPSGRIVEYGDHIYRASRYSFEANL 252
Cdd:COG2188  161 SLYELLEERyGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVEL 235
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 110-247 1.22e-36

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 126.56  E-value: 1.22e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395549008  110 EAGHKVQTTIQRYEAHPATEAEAEALKIEAGTLIVHIERTRFTNNEPIAVLTNLIPADIAP--TMQELESGSLYDLMRER 187
Cdd:pfam07702   1 AQGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPdlLEEDLEEGSLYDYLEER 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 395549008  188 -GVTLTSARQVIGARTATTKEAKLLSEHRGAALLTTQRTTYDPSGRIVEYGDHIYRASRYS 247
Cdd:pfam07702  81 yGLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 110-247 1.05e-32

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 116.24  E-value: 1.05e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395549008   110 EAGHKVQTTIQRYEAHPATEAEAEALKIEAGTLIVHIERTRFTNNEPIAVLTNLIPADIAPTM-QELESGSLYDLMRER- 187
Cdd:smart00866   1 AQGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLlEEDLSGSLYEYLEERl 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 395549008   188 ---GVTLTSARQVIGARTATTKEAKLLSEHRGAALLTTQRTTYDPSGRIVEYGDHIYRASRYS 247
Cdd:smart00866  81 glkIVRSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
PRK11402 PRK11402
transcriptional regulator PhoB;
19-251 3.98e-27

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 104.92  E-value: 3.98e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395549008  19 LDRSSPVPLYFQISEPIAELINTGALPADTRLEDELSMAARLRVSRPTARQALQRLVDRGLLTRRRGVGTIVSPSQVHRP 98
Cdd:PRK11402   2 TDRYSHQLLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVENA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395549008  99 LELTSLMKD-LVEAGHKVQTTIQRYEaHPATEAEAEALKIEAGTLIVHIERTRFTNNEPIAVLTNLIPADIAPTMQEL-- 175
Cdd:PRK11402  82 LLTVSGFTDfGVSQGKATKEKVIEQE-RVSAAPFCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDFDEIyv 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 395549008 176 ESGSLYDLMRER-GVTLTSARQVIGARTATTKEAKLLSEHRGAALLTTQRTTYDPSGRIVEYGDHIYRASRYSFEAN 251
Cdd:PRK11402 161 EGSSTYQLFQERfDTRVVSDKKTIDIFAATRPEAKWLKCELGEPLFRISKIAFDQNDKPVHVSELFCRANRVTLTID 237
PRK14999 PRK14999
histidine utilization repressor; Provisional
 21-249 2.22e-21

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 89.61  E-value: 2.22e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395549008  21 RSSPVPLYFQISEPIAELINTGALPADTRLEDELSMAARLRVSRPTARQALQRLVDRGLLTRRRGVGTIVSPSQVHRPL- 99
Cdd:PRK14999   7 RSAPAPFYETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEPKGQSALf 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395549008 100 ELTSLMKDLVEAGHKVQTTIQRYEAHPATEAEAEALKIEAGTLIVHIERTRFTNNEPIAVLTNLIPADIAPT--MQELES 177
Cdd:PRK14999  87 EVRSIAEEIAARRHQHRCEVLTLERVRANAIQASALNVNESDVIFHSIMVHYENDLPVQIEDRCVNADIAVDylTQDYRQ 166

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 395549008 178 GSLYDLMrERGVTLTSARQVIGARTATTKEAKLLSEHRGAALLTTQRTTYDpSGRIVEYGDHIYRASRYSFE 249
Cdd:PRK14999 167 TTPHAYL-SRIAPLTEGEHIVEAVRATAQECAWLTIKEHEPCLLIRRTTWS-ASRIVSHARLLFPGSRYRLQ 236
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 50-243 5.20e-21

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 88.29  E-value: 5.20e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395549008  50 LEDELSMAARLRVSRPTARQALQRLVDRGLLTRRRGVGTIVSPSQVHRPLEL-TSLMKDLVEAGHkvQTTIQRYEA--HP 126
Cdd:PRK10079  35 LPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVLMRPYDYPLNAqARFSQNLLDQGS--HPTSEKLLSvlRP 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395549008 127 ATEAEAEALKIEAGTLIVHIERTRFTNNEPIAVLTNLIP-ADIAPTMQELESGSLYDLMRER-GVTLTSARQVIGARTAT 204
Cdd:PRK10079 113 ASGHVADALGITEGENVIHLRTLRRVNGVALCLIDHYFAdLTWWPTLQRFDSGSLHDFLREQlGIALRRSQTRISARRAQ 192

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 395549008 205 TKEAKLLSEHRGAALLTTqRT--TYDPSGRIVEYGDHIYRA 243
Cdd:PRK10079 193 AKESQLLEIPNMSPLLCV-RTlnHRDGESSPAEYSVSLTRA 232
PRK09764 PRK09764
GntR family transcriptional regulator;
26-248 1.50e-17

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 79.10  E-value: 1.50e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395549008  26 PLYFQISEPIAELINTGALPADTRLEDELSMAARLRVSRPTARQALQRLVDRGLLTRRRGVGTIVSPSQVHRPL-ELTSL 104
Cdd:PRK09764   5 PLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIfQLTSF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395549008 105 MKDLVEAGHKVQTTIQRYEAHPATEAEAEALKIEAGTLIVHIERTRFTNNEPIAVLTNLIPADIAP--TMQELESgSLYD 182
Cdd:PRK09764  85 DEKLSDRHVDTHSEVLIFEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALFPdlTWQVMEN-SKYH 163

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 395549008 183 LMRE-RGVTLTSARQVIGARTATTKEAKLLSEHRGAALLTTQRTTYDPSGRIVEYGDHIYRASRYSF 248
Cdd:PRK09764 164 FIEEvKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYKF 230
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 26-91 4.05e-17

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 73.25  E-value: 4.05e-17
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 395549008  26 PLYFQISEPIAELINTGALPADTRLEDELSMAARLRVSRPTARQALQRLVDRGLLTRRRGVGTIVS 91
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 16-100 5.84e-16

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 76.79  E-value: 5.84e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395549008  16 DITLDRSSPVPLYFQISEPIAELINTGALPADTRLEDELSMAARLRVSRPTARQALQRLVDRGLLTRRRGVGTIVSPSQV 95
Cdd:COG1167    2 LIRLDRDSSGPLYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAARLP 81


                 ....*
gi 395549008  96 HRPLE 100
Cdd:COG1167   82 APAPA 86
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
23-108 1.14e-13

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 68.04  E-value: 1.14e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395549008  23 SPVPLYFQISEPIAELINTGALPADTRLEDELSMAARLRVSRPTARQALQRLVDRGLLTRRRGVGTIVSPSQVHRPLELT 102
Cdd:COG2186    4 RRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALLDPL 83


                 ....*.
gi 395549008 103 SLMKDL 108
Cdd:COG2186   84 ALLLAL 89
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
31-90 4.52e-12

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 59.51  E-value: 4.52e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 395549008    31 ISEPIAELINTGALPADTRLEDELSMAARLRVSRPTARQALQRLVDRGLLTRRRGVGTIV 90
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 27-90 3.77e-11

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 57.24  E-value: 3.77e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 395549008   27 LYFQISEPIAELINTGALPADTRLEDELSMAARLRVSRPTARQALQRLVDRGLLTRRRGVGTIV 90
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 30-136 7.67e-11

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 60.55  E-value: 7.67e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395549008  30 QISEPIAELINTGALPADTRLEDELSMAARLRVSRPTARQALQRLVDRGLLTRRRGVGTIVSPSQVHRPLE-----LTSL 104
Cdd:PRK10421   6 EVADRVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIRWRHETWSEQnivqpLKTL 85

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 395549008 105 MK-------DLVEAGHKVQTTIQRYEAHPATEAEAEALK 136
Cdd:PRK10421  86 MAddpdysfDILEARHAIEASTAWHAAMRATPGDKEKIQ 124
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
18-92 1.57e-08

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 53.39  E-value: 1.57e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 395549008  18 TLDRSSPVPLYFQISEPIAELINTGALPADTRLeDELSMAARLRVSRPTARQALQRLVDRGLLTRRRGVGTIVSP 92
Cdd:COG1802    3 SPSPLRRESLAEQVYEALREAILSGELPPGERL-SEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAP 76
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
31-91 4.96e-07

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 49.25  E-value: 4.96e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 395549008  31 ISEPIAELINTGALPADTRLEDELSMAARLRVSRPTARQALQRLVDRGLLTRRRGVGTIVS 91
Cdd:PRK09464  15 IEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQ 75
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
57-138 3.18e-04

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 39.80  E-value: 3.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395549008  57 AARLRVSRPTARQALQRLVDRGLLTRRRgvgtivspsqvHRPLELTslmkdlvEAGHKVQTTIqrYEAH----------- 125
Cdd:COG1321   31 AERLGVSPPSVTEMLKKLEEKGLVEYEP-----------YGGITLT-------EEGRELALRI--VRRHrllerflvevl 90

                         90
                 ....*....|....*
gi 395549008 126 --PATEAEAEALKIE 138
Cdd:COG1321   91 gvDWDEAHEEAERLE 105
COG3355 COG3355
Predicted transcriptional regulator [Transcription];
52-131 7.30e-04

Predicted transcriptional regulator [Transcription];


Pssm-ID: 442583 [Multi-domain]  Cd Length: 131  Bit Score: 38.79  E-value: 7.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395549008  52 DELsmAARLRVSRPTARQALQRLVDRGLLTRRRGVG---------TIVSPSQVHRplELTSLMKDLVEaghKVQTTIQRY 122
Cdd:COG3355   46 EEL--AEALDRSRSTVYRSLQKLLEAGLVEREKRNLegggypyvyYAIDPEELKE--KLVDDLDEWYE---KVGELIEEF 118


                 ....*....
gi 395549008 123 EAHPATEAE 131
Cdd:COG3355  119 EEEKADPLA 127
PRK10225 PRK10225
Uxu operon transcriptional regulator;
28-138 7.45e-04

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 40.00  E-value: 7.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395549008  28 YFQISEPIAELINTGALPADTRLEDELSMAARLRVSRPTARQALQRLVDRGLLTRRRGVGTIV--SPSQVHRPLELTSLM 105
Cdd:PRK10225  11 YQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVldSSGSHNTDSPDANVC 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 395549008 106 KD-----LVEAGHKVQTTIQRYEAHPATEAEA----EALKIE 138
Cdd:PRK10225  91 NDagpfeLLQARQLLESNIAEFAALQATREDIvkmrQALQLE 132
PRK15481 PRK15481
transcriptional regulatory protein PtsJ; Provisional
 30-91 3.43e-03

transcriptional regulatory protein PtsJ; Provisional


Pssm-ID: 185378 [Multi-domain]  Cd Length: 431  Bit Score: 38.10  E-value: 3.43e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 395549008  30 QISEPIAELINTGALPADTRLEDELSMAARLRVSRPTARQALQRLVDRGLLTRRRGVGTIVS 91
Cdd:PRK15481   9 EIFDSIRQLIQAGRLRPGDSLPPVRELASELGVNRNTVAAAYKRLVTAGLAQSQGRNGTVIR 70
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 57-87 5.33e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 34.49  E-value: 5.33e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 395549008   57 AARLRVSRPTARQALQRLVDRGLLTRRRGVG 87
Cdd:pfam12802  26 ARRLGISKQTVSRLVKRLEAKGLVEREPSPA 56
PRK11050 PRK11050
manganese-binding transcriptional regulator MntR;
33-86 6.65e-03

manganese-binding transcriptional regulator MntR;


Pssm-ID: 182927 [Multi-domain]  Cd Length: 152  Bit Score: 36.14  E-value: 6.65e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 395549008  33 EPIAELINTG--ALPADtrledelsMAARLRVSRPTARQALQRLVDRGLLTRR--RGV 86
Cdd:PRK11050  40 ELIADLIAEVgeARQVD--------IAARLGVSQPTVAKMLKRLARDGLVEMRpyRGV 89
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 52-100 8.65e-03

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 36.65  E-value: 8.65e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 395549008  52 DELsmAARLRVSRPTARQALQRLVDRGLLTRRRGVGTIVSPSQVHRPLE 100
Cdd:COG1349   23 EEL--AERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSAAAEPPFA 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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