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Conserved domains on  [gi|401267913|gb|EJR73968|]
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hypothetical protein IK5_02009 [Bacillus cereus VD154]

Protein Classification

alpha/beta fold hydrolase( domain architecture ID 11426811)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

PubMed:  1409539|12369917

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 8-251 2.40e-28

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


:

Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 107.39  E-value: 2.40e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401267913   8 EKETIIFIHGLVGNRRAFKKEQKRFSSSYNIITYDLLGHGDDKGEAIDFSLQRLVDQLLNLYEQEGIKKAHICALSYGCY 87
Cdd:COG0596   22 DGPPVVLLHGLPGSSYEWRPLIPALAAGYRVIAPDLRGHGRSDKPAGGYTLDDLADDLAALLDALGLERVVLVGHSMGGM 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401267913  88 ISTIFAQMHPEKVLSIchigghynnpsrlynVFQnfwekrgDEYSKWLSQYANTIfpsgilKANPFAvisrniyyrfglq 167
Cdd:COG0596  102 VALELAARHPERVAGL---------------VLV-------DEVLAALAEPLRRP------GLAPEA------------- 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401267913 168 lhssiIAQSLRHRLEFDLKSKLKSLPHPILWVMGEHDHLYK-SCLFDLKSILPNVLYREIPLAGHAANLFRPNYFHDLYD 246
Cdd:COG0596  141 -----LAALLRALARTDLRERLARITVPTLVIWGEKDPIVPpALARRLAELLPNAELVVLPGAGHFPPLEQPEAFAAALR 215


                 ....*
gi 401267913 247 RFLNG 251
Cdd:COG0596  216 DFLAR 220
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 8-251 2.40e-28

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 107.39  E-value: 2.40e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401267913   8 EKETIIFIHGLVGNRRAFKKEQKRFSSSYNIITYDLLGHGDDKGEAIDFSLQRLVDQLLNLYEQEGIKKAHICALSYGCY 87
Cdd:COG0596   22 DGPPVVLLHGLPGSSYEWRPLIPALAAGYRVIAPDLRGHGRSDKPAGGYTLDDLADDLAALLDALGLERVVLVGHSMGGM 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401267913  88 ISTIFAQMHPEKVLSIchigghynnpsrlynVFQnfwekrgDEYSKWLSQYANTIfpsgilKANPFAvisrniyyrfglq 167
Cdd:COG0596  102 VALELAARHPERVAGL---------------VLV-------DEVLAALAEPLRRP------GLAPEA------------- 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401267913 168 lhssiIAQSLRHRLEFDLKSKLKSLPHPILWVMGEHDHLYK-SCLFDLKSILPNVLYREIPLAGHAANLFRPNYFHDLYD 246
Cdd:COG0596  141 -----LAALLRALARTDLRERLARITVPTLVIWGEKDPIVPpALARRLAELLPNAELVVLPGAGHFPPLEQPEAFAAALR 215


                 ....*
gi 401267913 247 RFLNG 251
Cdd:COG0596  216 DFLAR 220
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 11-238 1.19e-17

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 79.47  E-value: 1.19e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401267913   11 TIIFIHGLVGNRRAFKKEQKRFSSS-YNIITYDLLGHGD-----DKGEAIDFSLQRLVDQLLNLYeqeGIKKAHICALSY 84
Cdd:pfam00561   2 PVLLLHGLPGSSDLWRKLAPALARDgFRVIALDLRGFGKssrpkAQDDYRTDDLAEDLEYILEAL---GLEKVNLVGHSM 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401267913   85 GCYISTIFAQMHPEKVLSICHIGGHYNNPSrlYNVFQNFWEKRgdeYSKWLSQYANTIFP--SGILKANPFAVISRNI-- 160
Cdd:pfam00561  79 GGLIALAYAAKYPDRVKALVLLGALDPPHE--LDEADRFILAL---FPGFFDGFVADFAPnpLGRLVAKLLALLLLRLrl 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401267913  161 ----------YYRFGLQLHSSIIAQSLRHRLEFDLKSKLKSLP---HPILWVMGEHDHL--YKSCLfDLKSILPNVLYRE 225
Cdd:pfam00561 154 lkalpllnkrFPSGDYALAKSLVTGALLFIETWSTELRAKFLGrldEPTLIIWGDQDPLvpPQALE-KLAQLFPNARLVV 232

                         250
                  ....*....|...
gi 401267913  226 IPLAGHAANLFRP 238
Cdd:pfam00561 233 IPDAGHFAFLEGP 245
menH_SHCHC TIGR03695
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; This protein catalyzes the ...
 8-250 3.13e-15

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; This protein catalyzes the formation of SHCHC, or (1 R,6 R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate, by elmination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Note that SHCHC synthase activity previously was attributed to MenD, which in fact is SEPHCHC synthase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 274729 [Multi-domain]  Cd Length: 252  Bit Score: 73.02  E-value: 3.13e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401267913    8 EKETIIFIHGLVGNRRAFKKEQKRFSSSYNIITYDLLGHG------DDKGEAIDFSLQRLVDQLLnlyEQEGIKKAHICA 81
Cdd:TIGR03695   1 AKPVLVFLHGFLGSGADWQALIEALGPHFRCLAIDLPGHGssqspsDIERYDFEEAAQLLLATLL---DQLGIEPFFLVG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401267913   82 LSYGCYISTIFAQMHPEKVLSICHIGGH------------YNNPSRLYNVFQ--------NFWEKRGdeyskwlsqyant 141
Cdd:TIGR03695  78 YSMGGRIALYYALQYPERVQGLILESGSpglqteeeraarRQNDEQLAQRFEqegleaflDDWYQQP------------- 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401267913  142 IFpSGILKANPF---AVISRniyyRfgLQLHSSIIAQSLR-----HRLefDLKSKLKSLPHPILWVMGEHDHLYKSCLFD 213
Cdd:TIGR03695 145 LF-ASQKNLPPEqrqALRAE----R--LANNPEGLAKMLRatglgKQP--SLWPKLQALKIPVLYLCGERDEKFVQIAKE 215

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 401267913  214 LKSILPNVLYREIPLAGHAANLFRPNYFHDLYDRFLN 250
Cdd:TIGR03695 216 MQKLIPNLTLHIIPNAGHNIHLENPEAFAKILLAFLE 252
PLN03084 PLN03084
alpha/beta hydrolase fold protein; Provisional
 7-123 9.48e-06

alpha/beta hydrolase fold protein; Provisional


Pssm-ID: 178633  Cd Length: 383  Bit Score: 46.03  E-value: 9.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401267913   7 SEKETIIFIHGLVGNRRAFKKEQKRFSSSYNIITYDLLGHG-DDK---GEAIDFSLQRLVDQLLNLYEQEGIKKAHICAL 82
Cdd:PLN03084 125 NNNPPVLLIHGFPSQAYSYRKVLPVLSKNYHAIAFDWLGFGfSDKpqpGYGFNYTLDEYVSSLESLIDELKSDKVSLVVQ 204

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 401267913  83 SYGCYISTIFAQMHPEKVLSICHIG-----GHYNNPSRLyNVFQNF 123
Cdd:PLN03084 205 GYFSPPVVKYASAHPDKIKKLILLNppltkEHAKLPSTL-SEFSNF 249
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 8-251 2.40e-28

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 107.39  E-value: 2.40e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401267913   8 EKETIIFIHGLVGNRRAFKKEQKRFSSSYNIITYDLLGHGDDKGEAIDFSLQRLVDQLLNLYEQEGIKKAHICALSYGCY 87
Cdd:COG0596   22 DGPPVVLLHGLPGSSYEWRPLIPALAAGYRVIAPDLRGHGRSDKPAGGYTLDDLADDLAALLDALGLERVVLVGHSMGGM 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401267913  88 ISTIFAQMHPEKVLSIchigghynnpsrlynVFQnfwekrgDEYSKWLSQYANTIfpsgilKANPFAvisrniyyrfglq 167
Cdd:COG0596  102 VALELAARHPERVAGL---------------VLV-------DEVLAALAEPLRRP------GLAPEA------------- 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401267913 168 lhssiIAQSLRHRLEFDLKSKLKSLPHPILWVMGEHDHLYK-SCLFDLKSILPNVLYREIPLAGHAANLFRPNYFHDLYD 246
Cdd:COG0596  141 -----LAALLRALARTDLRERLARITVPTLVIWGEKDPIVPpALARRLAELLPNAELVVLPGAGHFPPLEQPEAFAAALR 215


                 ....*
gi 401267913 247 RFLNG 251
Cdd:COG0596  216 DFLAR 220
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 11-238 1.19e-17

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 79.47  E-value: 1.19e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401267913   11 TIIFIHGLVGNRRAFKKEQKRFSSS-YNIITYDLLGHGD-----DKGEAIDFSLQRLVDQLLNLYeqeGIKKAHICALSY 84
Cdd:pfam00561   2 PVLLLHGLPGSSDLWRKLAPALARDgFRVIALDLRGFGKssrpkAQDDYRTDDLAEDLEYILEAL---GLEKVNLVGHSM 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401267913   85 GCYISTIFAQMHPEKVLSICHIGGHYNNPSrlYNVFQNFWEKRgdeYSKWLSQYANTIFP--SGILKANPFAVISRNI-- 160
Cdd:pfam00561  79 GGLIALAYAAKYPDRVKALVLLGALDPPHE--LDEADRFILAL---FPGFFDGFVADFAPnpLGRLVAKLLALLLLRLrl 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401267913  161 ----------YYRFGLQLHSSIIAQSLRHRLEFDLKSKLKSLP---HPILWVMGEHDHL--YKSCLfDLKSILPNVLYRE 225
Cdd:pfam00561 154 lkalpllnkrFPSGDYALAKSLVTGALLFIETWSTELRAKFLGrldEPTLIIWGDQDPLvpPQALE-KLAQLFPNARLVV 232

                         250
                  ....*....|...
gi 401267913  226 IPLAGHAANLFRP 238
Cdd:pfam00561 233 IPDAGHFAFLEGP 245
menH_SHCHC TIGR03695
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; This protein catalyzes the ...
 8-250 3.13e-15

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; This protein catalyzes the formation of SHCHC, or (1 R,6 R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate, by elmination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Note that SHCHC synthase activity previously was attributed to MenD, which in fact is SEPHCHC synthase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 274729 [Multi-domain]  Cd Length: 252  Bit Score: 73.02  E-value: 3.13e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401267913    8 EKETIIFIHGLVGNRRAFKKEQKRFSSSYNIITYDLLGHG------DDKGEAIDFSLQRLVDQLLnlyEQEGIKKAHICA 81
Cdd:TIGR03695   1 AKPVLVFLHGFLGSGADWQALIEALGPHFRCLAIDLPGHGssqspsDIERYDFEEAAQLLLATLL---DQLGIEPFFLVG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401267913   82 LSYGCYISTIFAQMHPEKVLSICHIGGH------------YNNPSRLYNVFQ--------NFWEKRGdeyskwlsqyant 141
Cdd:TIGR03695  78 YSMGGRIALYYALQYPERVQGLILESGSpglqteeeraarRQNDEQLAQRFEqegleaflDDWYQQP------------- 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401267913  142 IFpSGILKANPF---AVISRniyyRfgLQLHSSIIAQSLR-----HRLefDLKSKLKSLPHPILWVMGEHDHLYKSCLFD 213
Cdd:TIGR03695 145 LF-ASQKNLPPEqrqALRAE----R--LANNPEGLAKMLRatglgKQP--SLWPKLQALKIPVLYLCGERDEKFVQIAKE 215

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 401267913  214 LKSILPNVLYREIPLAGHAANLFRPNYFHDLYDRFLN 250
Cdd:TIGR03695 216 MQKLIPNLTLHIIPNAGHNIHLENPEAFAKILLAFLE 252
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 12-244 1.09e-09

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 56.71  E-value: 1.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401267913   12 IIFIHGLVGNRRAFkkeQKRFSSSYNIITYDLLGHGDDKGEAIDFSLQRLVDQLLNlyEQEGIKKAHICALSYGCYISTI 91
Cdd:pfam12697   1 VVLVHGAGLSAAPL---AALLAAGVAVLAPDLPGHGSSSPPPLDLADLADLAALLD--ELGAARPVVLVGHSLGGAVALA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401267913   92 FAQMHPEKVLSICHIGGHYNNPSRLYNVFQNFWEKRGDEysKWLSqyantifpsgiLKANPFAVISRNIYYRFGLQLHSS 171
Cdd:pfam12697  76 AAAAALVVGVLVAPLAAPPGLLAALLALLARLGAALAAP--AWLA-----------AESLARGFLDDLPADAEWAAALAR 142

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 401267913  172 iiAQSLRHRLEFDLKSKLKSLPHPILwVMGEHDHLYKSCLFDLKSILPNVLYREIPLAGHAAnLFRPNYFHDL 244
Cdd:pfam12697 143 --LAALLAALALLPLAAWRDLPVPVL-VLAEEDRLVPELAQRLLAALAGARLVVLPGAGHLP-LDDPEEVAEA 211
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
9-100 9.41e-07

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 48.46  E-value: 9.41e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401267913   9 KETIIFIHGLVGNRRAFKKEQKRFSSS-YNIITYDLLGHGDDKGEAIDF-SLQRLVD---QLLNLYEQEGIKKAHICALS 83
Cdd:COG2267   28 RGTVVLVHGLGEHSGRYAELAEALAAAgYAVLAFDLRGHGRSDGPRGHVdSFDDYVDdlrAALDALRARPGLPVVLLGHS 107

                         90
                 ....*....|....*..
gi 401267913  84 YGCYISTIFAQMHPEKV 100
Cdd:COG2267  108 MGGLIALLYAARYPDRV 124
PLN03084 PLN03084
alpha/beta hydrolase fold protein; Provisional
 7-123 9.48e-06

alpha/beta hydrolase fold protein; Provisional


Pssm-ID: 178633  Cd Length: 383  Bit Score: 46.03  E-value: 9.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401267913   7 SEKETIIFIHGLVGNRRAFKKEQKRFSSSYNIITYDLLGHG-DDK---GEAIDFSLQRLVDQLLNLYEQEGIKKAHICAL 82
Cdd:PLN03084 125 NNNPPVLLIHGFPSQAYSYRKVLPVLSKNYHAIAFDWLGFGfSDKpqpGYGFNYTLDEYVSSLESLIDELKSDKVSLVVQ 204

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 401267913  83 SYGCYISTIFAQMHPEKVLSICHIG-----GHYNNPSRLyNVFQNF 123
Cdd:PLN03084 205 GYFSPPVVKYASAHPDKIKKLILLNppltkEHAKLPSTL-SEFSNF 249
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 10-103 9.52e-06

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 46.09  E-value: 9.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401267913  10 ETIIFIHGLVGNRRAFKKEQKRFSSSYNIITYDLLGHGDDKGEAIDFSLQRLVDQLLNLYEQEGIKKAHICALSYGCYIS 89
Cdd:PRK14875 132 TPVVLIHGFGGDLNNWLFNHAALAAGRPVIALDLPGHGASSKAVGAGSLDELAAAVLAFLDALGIERAHLVGHSMGGAVA 211

                         90
                 ....*....|....
gi 401267913  90 TIFAQMHPEKVLSI 103
Cdd:PRK14875 212 LRLAARAPQRVASL 225
bioH TIGR01738
pimelyl-[acyl-carrier protein] methyl ester esterase; This CoA-binding enzyme is required for ...
 12-248 4.69e-05

pimelyl-[acyl-carrier protein] methyl ester esterase; This CoA-binding enzyme is required for the production of pimeloyl-coenzyme A, the substrate of the BioF protein early in the biosynthesis of biotin. Its exact function is unknown, but is proposed in ref 2. This enzyme belongs to the alpha/beta hydrolase fold family (pfam00561). Members of this family are restricted to the Proteobacteria. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273783 [Multi-domain]  Cd Length: 245  Bit Score: 43.65  E-value: 4.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401267913   12 IIFIHGLVGNRRAFKKEQKRFSSSYNIITYDLLGHGDDKGEAiDFSLQRLVDQLLnlyeQEGIKKAHICALSYGCYISTI 91
Cdd:TIGR01738   7 LVLIHGWGMNAEVFRCLDEELSAHFTLHLVDLPGHGRSRGFG-PLSLADMAEAIA----AQAPDPAIWLGWSLGGLVALH 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401267913   92 FAQMHPEKVLSICHIGG-----------HYNNPSrlynVFQNFWEKRGDEYSKWLSQY-----ANTIFPSGILKANPFAV 155
Cdd:TIGR01738  82 IAATHPDRVRALVTVASspcfsaredwpEGIKPD----VLTGFQQQLSDDYQRTIERFlalqtLGTPTARQDARALKQTL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401267913  156 ISRNIYYRFGLQLHSSIIAqslrhrlEFDLKSKLKSLPHPILWVMGEHDHLY-KSCLFDLKSILPNVLYREIPLAGHAAN 234
Cdd:TIGR01738 158 LARPTPNVQVLQAGLEILA-------TVDLRQPLQNISVPFLRLYGYLDGLVpAKVVPMLDKLAPHSELYIFAKAAHAPF 230

                         250
                  ....*....|....
gi 401267913  235 LFRPNYFHDLYDRF 248
Cdd:TIGR01738 231 LSHAEAFCALLVAF 244
PLN03087 PLN03087
BODYGUARD 1 domain containing hydrolase; Provisional
 9-103 1.06e-03

BODYGUARD 1 domain containing hydrolase; Provisional


Pssm-ID: 215567  Cd Length: 481  Bit Score: 39.79  E-value: 1.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401267913   9 KETIIFIHGLVGNRrAFKKEQ--KRFS----SSYNIITYDLLGHGDDKGEAID-FSLQRLVDQL-LNLYEQEGIKKAHIC 80
Cdd:PLN03087 201 KEDVLFIHGFISSS-AFWTETlfPNFSdaakSTYRLFAVDLLGFGRSPKPADSlYTLREHLEMIeRSVLERYKVKSFHIV 279

                         90       100
                 ....*....|....*....|...
gi 401267913  81 ALSYGCYISTIFAQMHPEKVLSI 103
Cdd:PLN03087 280 AHSLGCILALALAVKHPGAVKSL 302
PRK08775 PRK08775
homoserine O-succinyltransferase;
17-113 3.69e-03

homoserine O-succinyltransferase;


Pssm-ID: 181553 [Multi-domain]  Cd Length: 343  Bit Score: 38.23  E-value: 3.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401267913  17 GLVGNRRAFKKEQKRfsssynIITYDLLGHGDDKGEAIDFSLQrlVDQLLNLYEQEGIKKAH-ICALSYGCYISTIFAQM 95
Cdd:PRK08775  87 GLVGSGRALDPARFR------LLAFDFIGADGSLDVPIDTADQ--ADAIALLLDALGIARLHaFVGYSYGALVGLQFASR 158

                         90
                 ....*....|....*....
gi 401267913  96 HPEKVLS-ICHIGGHYNNP 113
Cdd:PRK08775 159 HPARVRTlVVVSGAHRAHP 177
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
11-139 4.28e-03

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 37.30  E-value: 4.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401267913  11 TIIFIHGLVGNR-RAFKKEQKRFSSS-YNIITYDLLGHGDDKGEAIDFSLQ---RLVDQLLnlyEQEGIKKAHICAL--S 83
Cdd:COG1506   25 VVVYVHGGPGSRdDSFLPLAQALASRgYAVLAPDYRGYGESAGDWGGDEVDdvlAAIDYLA---ARPYVDPDRIGIYghS 101

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 401267913  84 YGCYISTIFAQMHPEKVLSICHIGGhYNNPSRLYNVFQNFWEKRGDEYSKWLSQYA 139
Cdd:COG1506  102 YGGYMALLAAARHPDRFKAAVALAG-VSDLRSYYGTTREYTERLMGGPWEDPEAYA 156
PLN02980 PLN02980
2-oxoglutarate decarboxylase/ hydro-lyase/ magnesium ion binding / thiamin pyrophosphate ...
 6-238 4.57e-03

2-oxoglutarate decarboxylase/ hydro-lyase/ magnesium ion binding / thiamin pyrophosphate binding


Pssm-ID: 215530 [Multi-domain]  Cd Length: 1655  Bit Score: 38.30  E-value: 4.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401267913    6 HSEKETIIFIHGLVGNRRAFKKEQKRFSSSYNIITYDLLGHGDDK--------GEAIDFSLQRLVDQLLNLYEQEGIKKA 77
Cdd:PLN02980 1368 NAEGSVVLFLHGFLGTGEDWIPIMKAISGSARCISIDLPGHGGSKiqnhaketQTEPTLSVELVADLLYKLIEHITPGKV 1447

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401267913   78 HICALSYGCYISTIFAQMHPEKVLSICHIGGhynNPSRLYNVFQNFWEKRGDEYSKWL----------SQYANTIFPSgi 147
Cdd:PLN02980 1448 TLVGYSMGARIALYMALRFSDKIEGAVIISG---SPGLKDEVARKIRSAKDDSRARMLidhgleifleNWYSGELWKS-- 1522

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401267913  148 LKANPfavisrniyyRFglqlhSSIIAQSLRHRlefDLKS------------------KLKSLPHPILWVMGEHDHLYKS 209
Cdd:PLN02980 1523 LRNHP----------HF-----NKIVASRLLHK---DVPSlakllsdlsigrqpslweDLKQCDTPLLLVVGEKDVKFKQ 1584

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 401267913  210 CLFDLK----------SILPNVLYR--EIPLAGHAANLFRP 238
Cdd:PLN02980 1585 IAQKMYreigkskesgNDKGKEIIEivEIPNCGHAVHLENP 1625
PRK11126 PRK11126
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; Provisional
 184-250 6.63e-03

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; Provisional


Pssm-ID: 236855 [Multi-domain]  Cd Length: 242  Bit Score: 37.13  E-value: 6.63e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 401267913 184 DLKSKLKSLPHPILWVMGEHDHLYKSCLFDLKsiLPnvlYREIPLAGHAANLFRPNYFHDLYDRFLN 250
Cdd:PRK11126 179 DLRPALQALTFPFYYLCGERDSKFQALAQQLA--LP---LHVIPNAGHNAHRENPAAFAASLAQILR 240
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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