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Conserved domains on  [gi|402276382|gb|EJU25492|]
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nitrate reductase molybdenum cofactor assembly chaperone [Selenomonas sp. CM52]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NarJ super family cl43633
Nitrate reductase assembly protein NarJ, required for insertion of molybdenum cofactor [Energy ...
 16-163 3.23e-17

Nitrate reductase assembly protein NarJ, required for insertion of molybdenum cofactor [Energy production and conversion, Inorganic ion transport and metabolism, Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG2180:

Pssm-ID: 441783  Cd Length: 181  Bit Score: 74.91  E-value: 3.23e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402276382  16 EYPSEAWWqdfDAYRAAAAEIETKQAREVLEELFDYAQELGNKAYEEQYVRSFEFSPNTNLYLTTQDRTDFGKQASEMHV 95
Cdd:COG2180   17 DYPDEELL---AALPELRAALAEAAAREALAAFLDHLAALDLLDLQEEYVETFDRGRRTSLYLFEHVHGESRDRGQALVD 93

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 402276382  96 YKQLFLKNGFD-TQNELPDYLPALLELAAALPEEKAAEVFRTMKDKLKLLRDRFIEAKLAYAFLLDVVL 163
Cdd:COG2180   94 LKELYRAAGLElDDGELPDYLPLVLEFLATLDPEEARALLGDIRHGLELLRARLEERGSPYAALFDALL 162
 
Name Accession Description Interval E-value
NarJ COG2180
Nitrate reductase assembly protein NarJ, required for insertion of molybdenum cofactor [Energy ...
 16-163 3.23e-17

Nitrate reductase assembly protein NarJ, required for insertion of molybdenum cofactor [Energy production and conversion, Inorganic ion transport and metabolism, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441783  Cd Length: 181  Bit Score: 74.91  E-value: 3.23e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402276382  16 EYPSEAWWqdfDAYRAAAAEIETKQAREVLEELFDYAQELGNKAYEEQYVRSFEFSPNTNLYLTTQDRTDFGKQASEMHV 95
Cdd:COG2180   17 DYPDEELL---AALPELRAALAEAAAREALAAFLDHLAALDLLDLQEEYVETFDRGRRTSLYLFEHVHGESRDRGQALVD 93

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 402276382  96 YKQLFLKNGFD-TQNELPDYLPALLELAAALPEEKAAEVFRTMKDKLKLLRDRFIEAKLAYAFLLDVVL 163
Cdd:COG2180   94 LKELYRAAGLElDDGELPDYLPLVLEFLATLDPEEARALLGDIRHGLELLRARLEERGSPYAALFDALL 162
narJ TIGR00684
nitrate reductase molybdenum cofactor assembly chaperone; This protein is termed NarJ in most ...
 16-162 2.32e-07

nitrate reductase molybdenum cofactor assembly chaperone; This protein is termed NarJ in most species that have a single copy, and has been called the delta subunit of nitrate reductase. However, although it is required for correct assembly of active enzyme, it dissociates and is not part of the enzyme. Two hits to this model are found each in E. coli and in Mycobacterium tuberculosis, but in each case duplication to create paralogs appears to be recent. The NarX protein of Mycobacterium tuberculosis includes one of these paralogs as a domain, fused to structural domains of nitrate reductases before and after the NarJ-homologous region. [Protein fate, Protein folding and stabilization]


Pssm-ID: 273218  Cd Length: 152  Bit Score: 47.91  E-value: 2.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402276382   16 EYPSEAWWQDFDAYRAAAAEIeTKQAREVLEELFDYAQELGNKAYEEQYVRSFEFSPNTNLYLTTQDRTDFGKQASEMHV 95
Cdd:TIGR00684   5 SYPDEDLEELLRMREALKALL-IGEDAEALGLFMEFLEKLDPEAADAQYVETFDMGRKTSMYLTYLLKGEERMRGQEMLE 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 402276382   96 YKQLFLKNGFD-TQNELPDYLPALLELAAALPEEKAAEVF-RTMKDKLKLLRDRFIEAKLAYAFLLDVV 162
Cdd:TIGR00684  84 LKSHYEQQGDMpVDRELPDYLPLMLEYLALVDPEAARRFAkKYLQPWVGELASRLEKNRSLYALLAKAL 152
 
Name Accession Description Interval E-value
NarJ COG2180
Nitrate reductase assembly protein NarJ, required for insertion of molybdenum cofactor [Energy ...
 16-163 3.23e-17

Nitrate reductase assembly protein NarJ, required for insertion of molybdenum cofactor [Energy production and conversion, Inorganic ion transport and metabolism, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441783  Cd Length: 181  Bit Score: 74.91  E-value: 3.23e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402276382  16 EYPSEAWWqdfDAYRAAAAEIETKQAREVLEELFDYAQELGNKAYEEQYVRSFEFSPNTNLYLTTQDRTDFGKQASEMHV 95
Cdd:COG2180   17 DYPDEELL---AALPELRAALAEAAAREALAAFLDHLAALDLLDLQEEYVETFDRGRRTSLYLFEHVHGESRDRGQALVD 93

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 402276382  96 YKQLFLKNGFD-TQNELPDYLPALLELAAALPEEKAAEVFRTMKDKLKLLRDRFIEAKLAYAFLLDVVL 163
Cdd:COG2180   94 LKELYRAAGLElDDGELPDYLPLVLEFLATLDPEEARALLGDIRHGLELLRARLEERGSPYAALFDALL 162
narJ TIGR00684
nitrate reductase molybdenum cofactor assembly chaperone; This protein is termed NarJ in most ...
 16-162 2.32e-07

nitrate reductase molybdenum cofactor assembly chaperone; This protein is termed NarJ in most species that have a single copy, and has been called the delta subunit of nitrate reductase. However, although it is required for correct assembly of active enzyme, it dissociates and is not part of the enzyme. Two hits to this model are found each in E. coli and in Mycobacterium tuberculosis, but in each case duplication to create paralogs appears to be recent. The NarX protein of Mycobacterium tuberculosis includes one of these paralogs as a domain, fused to structural domains of nitrate reductases before and after the NarJ-homologous region. [Protein fate, Protein folding and stabilization]


Pssm-ID: 273218  Cd Length: 152  Bit Score: 47.91  E-value: 2.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402276382   16 EYPSEAWWQDFDAYRAAAAEIeTKQAREVLEELFDYAQELGNKAYEEQYVRSFEFSPNTNLYLTTQDRTDFGKQASEMHV 95
Cdd:TIGR00684   5 SYPDEDLEELLRMREALKALL-IGEDAEALGLFMEFLEKLDPEAADAQYVETFDMGRKTSMYLTYLLKGEERMRGQEMLE 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 402276382   96 YKQLFLKNGFD-TQNELPDYLPALLELAAALPEEKAAEVF-RTMKDKLKLLRDRFIEAKLAYAFLLDVV 162
Cdd:TIGR00684  84 LKSHYEQQGDMpVDRELPDYLPLMLEYLALVDPEAARRFAkKYLQPWVGELASRLEKNRSLYALLAKAL 152
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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