|
Name |
Accession |
Description |
Interval |
E-value |
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
1-392 |
8.56e-162 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 462.69 E-value: 8.56e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 1 MSFTKFQFKNYIREALKELKFTTPTEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIFQQLD-EASDSVQAVITAPSR 79
Cdd:COG0513 2 MSFADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRLDpSRPRAPQALILAPTR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 80 ELATQIYQVARQISAHSDVevRVVNYVGGTDKARQIEKLEsNQPHIVIGTPGRIYDLVKSGDLAIHKAKTFVVDEADMTL 159
Cdd:COG0513 82 ELALQVAEELRKLAKYLGL--RVATVYGGVSIGRQIRALK-RGVDIVVATPGRLLDLIERGALDLSGVETLVLDEADRML 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 160 DMGFLETVDKIADSLPKDLQFMVFSATIPQKLQPFLKKYLSNPVMEKIKTKTVISDTIDNWLISTKGHDKNAQIYQLTQS 239
Cdd:COG0513 159 DMGFIEDIERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPENATAETIEQRYYLVDKRDKLELLRRLLRD 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 240 MQPYLAMIFVNTKTRADELHSYLTAQGLKVAKIHGDIAPRERKRIMNQVQNLDFEYIVATDLAARGIDIEGVSHVINDAI 319
Cdd:COG0513 239 EDPERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDIDDVSHVINYDL 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 444285213 320 PQDLSFFVHRVGRTGRNGLPGTAITLYQPSDDSDIRELEKL-GIKFSPKMVKDGEFQDTYDRDRRANREKKQDK 392
Cdd:COG0513 319 PEDPEDYVHRIGRTGRAGAEGTAISLVTPDERRLLRAIEKLiGQKIEEEELPGFEPVEEKRLERLKPKIKEKLK 392
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
12-203 |
9.46e-84 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 255.44 E-value: 9.46e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 12 IREALKELKFTTPTEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIFQQLDE----ASDSVQAVITAPSRELATQIYQ 87
Cdd:cd00268 1 LLKALKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKLLPepkkKGRGPQALVLAPTRELAMQIAE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 88 VARQISAHSDVevRVVNYVGGTDKARQIEKLEsNQPHIVIGTPGRIYDLVKSGDLAIHKAKTFVVDEADMTLDMGFLETV 167
Cdd:cd00268 81 VARKLGKGTGL--KVAAIYGGAPIKKQIEALK-KGPDIVVGTPGRLLDLIERGKLDLSNVKYLVLDEADRMLDMGFEEDV 157
|
170 180 190
....*....|....*....|....*....|....*.
gi 444285213 168 DKIADSLPKDLQFMVFSATIPQKLQPFLKKYLSNPV 203
Cdd:cd00268 158 EKILSALPKDRQTLLFSATLPEEVKELAKKFLKNPV 193
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
16-366 |
4.15e-80 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 255.11 E-value: 4.15e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 16 LKELKFTTPTEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIFQQLDEASDSVQAVITAPSRELATQiyqVARQIS-- 93
Cdd:PRK11776 19 LNELGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGLLQKLDVKRFRVQALVLCPTRELADQ---VAKEIRrl 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 94 AHSDVEVRVVNYVGGTDKARQIEKLEsNQPHIVIGTPGRIYDLVKSGDLAIHKAKTFVVDEADMTLDMGFLETVDKIADS 173
Cdd:PRK11776 96 ARFIPNIKVLTLCGGVPMGPQIDSLE-HGAHIIVGTPGRILDHLRKGTLDLDALNTLVLDEADRMLDMGFQDAIDAIIRQ 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 174 LPKDLQFMVFSATIPQKLQPFLKKYLSNPVMEKIKTkTVISDTIDNWLISTKGHDKNAQIYQLTQSMQPYLAMIFVNTKT 253
Cdd:PRK11776 175 APARRQTLLFSATYPEGIAAISQRFQRDPVEVKVES-THDLPAIEQRFYEVSPDERLPALQRLLLHHQPESCVVFCNTKK 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 254 RADELHSYLTAQGLKVAKIHGDIAPRERKRIMNQVQNLDFEYIVATDLAARGIDIEGVSHVINDAIPQDLSFFVHRVGRT 333
Cdd:PRK11776 254 ECQEVADALNAQGFSALALHGDLEQRDRDQVLVRFANRSCSVLVATDVAARGLDIKALEAVINYELARDPEVHVHRIGRT 333
|
330 340 350
....*....|....*....|....*....|....
gi 444285213 334 GRNGLPGTAITLYQPSDDSDIRELEK-LGIKFSP 366
Cdd:PRK11776 334 GRAGSKGLALSLVAPEEMQRANAIEDyLGRKLNW 367
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
3-371 |
7.66e-70 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 229.03 E-value: 7.66e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 3 FTKFQFKNYIREALKELKFTTPTEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIFQQLDEASDSVQ-------AVIT 75
Cdd:PRK01297 89 FHDFNLAPELMHAIHDLGFPYCTPIQAQVLGYTLAGHDAIGRAQTGTGKTAAFLISIINQLLQTPPPKErymgeprALII 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 76 APSRELATQIYQVARQISAHSDVEVrvVNYVGGTDKARQIEKLESNQPHIVIGTPGRIYDLVKSGDLAIHKAKTFVVDEA 155
Cdd:PRK01297 169 APTRELVVQIAKDAAALTKYTGLNV--MTFVGGMDFDKQLKQLEARFCDILVATPGRLLDFNQRGEVHLDMVEVMVLDEA 246
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 156 DMTLDMGFLETVDKIADSLPK--DLQFMVFSATIPQKLQPFLKKYLSNPVMEKIKTKTVISDTIDNWLISTKGHDKNAQI 233
Cdd:PRK01297 247 DRMLDMGFIPQVRQIIRQTPRkeERQTLLFSATFTDDVMNLAKQWTTDPAIVEIEPENVASDTVEQHVYAVAGSDKYKLL 326
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 234 YQLTQSMQPYLAMIFVNTKTRADELHSYLTAQGLKVAKIHGDIAPRERKRIMNQVQNLDFEYIVATDLAARGIDIEGVSH 313
Cdd:PRK01297 327 YNLVTQNPWERVMVFANRKDEVRRIEERLVKDGINAAQLSGDVPQHKRIKTLEGFREGKIRVLVATDVAGRGIHIDGISH 406
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 444285213 314 VINDAIPQDLSFFVHRVGRTGRNGLPGTAITLYQPSDDSDIRELEK-LGIKFSPKMVKD 371
Cdd:PRK01297 407 VINFTLPEDPDDYVHRIGRTGRAGASGVSISFAGEDDAFQLPEIEElLGRKISCEMPPA 465
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
1-359 |
9.41e-64 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 216.64 E-value: 9.41e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 1 MSFTKFQFKNYIREALKELKFTTPTEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIFQQLDEASDSVQAVITAPSRE 80
Cdd:PRK11634 6 TTFADLGLKAPILEALNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLLHNLDPELKAPQILVLAPTRE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 81 LATQIYQVARQISAHSDvEVRVVNYVGGTDKARQIEKLESNqPHIVIGTPGRIYDLVKSGDLAIHKAKTFVVDEADMTLD 160
Cdd:PRK11634 86 LAVQVAEAMTDFSKHMR-GVNVVALYGGQRYDVQLRALRQG-PQIVVGTPGRLLDHLKRGTLDLSKLSGLVLDEADEMLR 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 161 MGFLETVDKIADSLPKDLQFMVFSATIPQKLQPFLKKYLSNPVMEKIKTKTVISDTIDNWLISTKGHDKNAQIYQLTQSM 240
Cdd:PRK11634 164 MGFIEDVETIMAQIPEGHQTALFSATMPEAIRRITRRFMKEPQEVRIQSSVTTRPDISQSYWTVWGMRKNEALVRFLEAE 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 241 QPYLAMIFVNTKTRADELHSYLTAQGLKVAKIHGDIAPRERKRIMNQVQNLDFEYIVATDLAARGIDIEGVSHVINDAIP 320
Cdd:PRK11634 244 DFDAAIIFVRTKNATLEVAEALERNGYNSAALNGDMNQALREQTLERLKDGRLDILIATDVAARGLDVERISLVVNYDIP 323
|
330 340 350
....*....|....*....|....*....|....*....
gi 444285213 321 QDLSFFVHRVGRTGRNGLPGTAITLYQPSDDSDIRELEK 359
Cdd:PRK11634 324 MDSESYVHRIGRTGRAGRAGRALLFVENRERRLLRNIER 362
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
1-345 |
1.29e-63 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 211.34 E-value: 1.29e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 1 MSFTKFQFKNYIREALKELKFTTPTEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIFQQLDE--ASDSVQA--VITA 76
Cdd:PRK11192 1 TTFSELELDESLLEALQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQHLLDfpRRKSGPPriLILT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 77 PSRELATQIYQVARQISAHSDVEVRVVNyvGGTDKARQIEKLESNQpHIVIGTPGRIYDLVKSGDLAIHKAKTFVVDEAD 156
Cdd:PRK11192 81 PTRELAMQVADQARELAKHTHLDIATIT--GGVAYMNHAEVFSENQ-DIVVATPGRLLQYIKEENFDCRAVETLILDEAD 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 157 MTLDMGFLETVDKIADSLPKDLQFMVFSATIPQK-LQPFLKKYLSNPVM--------EKIKtktvisdtIDNW--LISTK 225
Cdd:PRK11192 158 RMLDMGFAQDIETIAAETRWRKQTLLFSATLEGDaVQDFAERLLNDPVEveaepsrrERKK--------IHQWyyRADDL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 226 GHdKNAQIYQLTQSMQPYLAMIFVNTKTRADELHSYLTAQGLKVAKIHGDIAPRERKRIMNQVQNLDFEYIVATDLAARG 305
Cdd:PRK11192 230 EH-KTALLCHLLKQPEVTRSIVFVRTRERVHELAGWLRKAGINCCYLEGEMVQAKRNEAIKRLTDGRVNVLVATDVAARG 308
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 444285213 306 IDIEGVSHVINDAIPQDLSFFVHRVGRTGRNGLPGTAITL 345
Cdd:PRK11192 309 IDIDDVSHVINFDMPRSADTYLHRIGRTGRAGRKGTAISL 348
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
21-359 |
1.59e-63 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 210.45 E-value: 1.59e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 21 FTTPTEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIFQQLDEASDSVQAVITAPSRELATQIYQVARQISAHSDVEV 100
Cdd:PTZ00424 48 FEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATFVIAALQLIDYDLNACQALILAPTRELAQQIQKVVLALGDYLKVRC 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 101 RVVnyVGGTDKARQIEKLESNQpHIVIGTPGRIYDLVKSGDLAIHKAKTFVVDEADMTLDMGFLETVDKIADSLPKDLQF 180
Cdd:PTZ00424 128 HAC--VGGTVVRDDINKLKAGV-HMVVGTPGRVYDMIDKRHLRVDDLKLFILDEADEMLSRGFKGQIYDVFKKLPPDVQV 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 181 MVFSATIPQKLQPFLKKYLSNPVMEKIKTKTVISDTIDNWLISTKGHD-KNAQIYQLTQSMQPYLAMIFVNTKTRADELH 259
Cdd:PTZ00424 205 ALFSATMPNEILELTTKFMRDPKRILVKKDELTLEGIRQFYVAVEKEEwKFDTLCDLYETLTITQAIIYCNTRRKVDYLT 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 260 SYLTAQGLKVAKIHGDIAPRERKRIMNQVQNLDFEYIVATDLAARGIDIEGVSHVINDAIPQDLSFFVHRVGRTGRNGLP 339
Cdd:PTZ00424 285 KKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITTDLLARGIDVQQVSLVINYDLPASPENYIHRIGRSGRFGRK 364
|
330 340
....*....|....*....|
gi 444285213 340 GTAITLYQPSDDSDIRELEK 359
Cdd:PTZ00424 365 GVAINFVTPDDIEQLKEIER 384
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
2-360 |
1.24e-62 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 211.94 E-value: 1.24e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 2 SFTKFQFKNYIREALKELKFTTPTEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIF-----QQLDEASDSVQAVITA 76
Cdd:PTZ00110 131 SFEYTSFPDYILKSLKNAGFTEPTPIQVQGWPIALSGRDMIGIAETGSGKTLAFLLPAIvhinaQPLLRYGDGPIVLVLA 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 77 PSRELATQIYQVARQISAHSDVEVRVVnyVGGTDKARQIEKLEsNQPHIVIGTPGRIYDLVKSGDLAIHKAKTFVVDEAD 156
Cdd:PTZ00110 211 PTRELAEQIREQCNKFGASSKIRNTVA--YGGVPKRGQIYALR-RGVEILIACPGRLIDFLESNVTNLRRVTYLVLDEAD 287
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 157 MTLDMGFLETVDKIADSLPKDLQFMVFSATIPQKLQPFLKKYLSN-PVMEKIKTKTV-ISDTIDNWLISTKGHDKNAQIY 234
Cdd:PTZ00110 288 RMLDMGFEPQIRKIVSQIRPDRQTLMWSATWPKEVQSLARDLCKEePVHVNVGSLDLtACHNIKQEVFVVEEHEKRGKLK 367
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 235 QLTQSM--QPYLAMIFVNTKTRADELHSYLTAQGLKVAKIHGDIAPRERKRIMNQVQNLDFEYIVATDLAARGIDIEGVS 312
Cdd:PTZ00110 368 MLLQRImrDGDKILIFVETKKGADFLTKELRLDGWPALCIHGDKKQEERTWVLNEFKTGKSPIMIATDVASRGLDVKDVK 447
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 444285213 313 HVINDAIPQDLSFFVHRVGRTGRNGLPGTAITLYQPSDDSDIRELEKL 360
Cdd:PTZ00110 448 YVINFDFPNQIEDYVHRIGRTGRAGAKGASYTFLTPDKYRLARDLVKV 495
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
3-345 |
1.04e-59 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 200.97 E-value: 1.04e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 3 FTKFQFKNYIREALKELKFTTPTEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIFQQL--DEASDSVQ-----AVIT 75
Cdd:PRK04837 10 FSDFALHPQVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTATFHYLlsHPAPEDRKvnqprALIM 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 76 APSRELATQIYQVARQISAHSDVEVRVVnYvGGTDKARQIEKLEsNQPHIVIGTPGRIYDLVKSGDLAIHKAKTFVVDEA 155
Cdd:PRK04837 90 APTRELAVQIHADAEPLAQATGLKLGLA-Y-GGDGYDKQLKVLE-SGVDILIGTTGRLIDYAKQNHINLGAIQVVVLDEA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 156 DMTLDMGFLetvdkiadslpKDLQF-------------MVFSATIPQKLQPFLKKYLSNPVMEKIKTKTVISDTIDNWLI 222
Cdd:PRK04837 167 DRMFDLGFI-----------KDIRWlfrrmppanqrlnMLFSATLSYRVRELAFEHMNNPEYVEVEPEQKTGHRIKEELF 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 223 STKGHDKNAQIYQLTQSMQPYLAMIFVNTKTRADELHSYLTAQGLKVAKIHGDIAPRERKRIMNQVQNLDFEYIVATDLA 302
Cdd:PRK04837 236 YPSNEEKMRLLQTLIEEEWPDRAIIFANTKHRCEEIWGHLAADGHRVGLLTGDVAQKKRLRILEEFTRGDLDILVATDVA 315
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 444285213 303 ARGIDIEGVSHVINDAIPQDLSFFVHRVGRTGRNGLPGTAITL 345
Cdd:PRK04837 316 ARGLHIPAVTHVFNYDLPDDCEDYVHRIGRTGRAGASGHSISL 358
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
1-372 |
3.38e-58 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 197.72 E-value: 3.38e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 1 MSFTKFQFKNYIREALKELKFTTPTEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIFQQLD------EASDSVQAVI 74
Cdd:PRK10590 1 MSFDSLGLSPDILRAVAEQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLItrqphaKGRRPVRALI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 75 TAPSRELATQIYQVARQISAHSDVEVRVVnyVGGTDKARQIEKLESNQpHIVIGTPGRIYDLVKSGDLAIHKAKTFVVDE 154
Cdd:PRK10590 81 LTPTRELAAQIGENVRDYSKYLNIRSLVV--FGGVSINPQMMKLRGGV-DVLVATPGRLLDLEHQNAVKLDQVEILVLDE 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 155 ADMTLDMGFLETVDKIADSLPKDLQFMVFSATIPQKLQPFLKKYLSNPVMEKIKTKTVISDTIDNWLISTKGHDKNAQIY 234
Cdd:PRK10590 158 ADRMLDMGFIHDIRRVLAKLPAKRQNLLFSATFSDDIKALAEKLLHNPLEIEVARRNTASEQVTQHVHFVDKKRKRELLS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 235 QLTQSMQPYLAMIFVNTKTRADELHSYLTAQGLKVAKIHGDIAPRERKRIMNQVQNLDFEYIVATDLAARGIDIEGVSHV 314
Cdd:PRK10590 238 QMIGKGNWQQVLVFTRTKHGANHLAEQLNKDGIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDIAARGLDIEELPHV 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 444285213 315 INDAIPQDLSFFVHRVGRTGRNGLPGTAITLYQPSDDSDIRELEKLGIKFSPKMVKDG 372
Cdd:PRK10590 318 VNYELPNVPEDYVHRIGRTGRAAATGEALSLVCVDEHKLLRDIEKLLKKEIPRIAIPG 375
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
3-204 |
6.84e-56 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 184.04 E-value: 6.84e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 3 FTKFQFKNYIREALKELKFTTPTEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIFQQLDEASDSVQAVITAPSRELA 82
Cdd:cd17940 1 FEDYGLKRELLMGIFEKGFEKPSPIQEESIPIALSGRDILARAKNGTGKTGAYLIPILEKIDPKKDVIQALILVPTRELA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 83 TQIYQVARQISAHSDVEVRVVnyVGGTDKARQIEKLeSNQPHIVIGTPGRIYDLVKSGDLAIHKAKTFVVDEADMTLDMG 162
Cdd:cd17940 81 LQTSQVCKELGKHMGVKVMVT--TGGTSLRDDIMRL-YQTVHVLVGTPGRILDLAKKGVADLSHCKTLVLDEADKLLSQD 157
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 444285213 163 FLETVDKIADSLPKDLQFMVFSATIPQKLQPFLKKYLSNPVM 204
Cdd:cd17940 158 FQPIIEKILNFLPKERQILLFSATFPLTVKNFMDRHMHNPYE 199
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
1-345 |
1.32e-55 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 193.63 E-value: 1.32e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 1 MSFTKFQFKNYIREALKELKFTTPTEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIFQQL-------DEASDSVQAV 73
Cdd:PRK04537 9 LTFSSFDLHPALLAGLESAGFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMNRLlsrpalaDRKPEDPRAL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 74 ITAPSRELATQIYQVARQISAhsDVEVRVVNYVGGTDKARQIEKLESNQpHIVIGTPGRIYDLVKSGDL-AIHKAKTFVV 152
Cdd:PRK04537 89 ILAPTRELAIQIHKDAVKFGA--DLGLRFALVYGGVDYDKQRELLQQGV-DVIIATPGRLIDYVKQHKVvSLHACEICVL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 153 DEADMTLDMGFLETVDKIADSLPK--DLQFMVFSATIPQKLQPFLKKYLSNPVMEKIKTKTVISDTIDNWLISTKGHDKN 230
Cdd:PRK04537 166 DEADRMFDLGFIKDIRFLLRRMPErgTRQTLLFSATLSHRVLELAYEHMNEPEKLVVETETITAARVRQRIYFPADEEKQ 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 231 AQIYQLTQSMQPYLAMIFVNTKTRADELHSYLTAQGLKVAKIHGDIAPRERKRIMNQVQNLDFEYIVATDLAARGIDIEG 310
Cdd:PRK04537 246 TLLLGLLSRSEGARTMVFVNTKAFVERVARTLERHGYRVGVLSGDVPQKKRESLLNRFQKGQLEILVATDVAARGLHIDG 325
|
330 340 350
....*....|....*....|....*....|....*
gi 444285213 311 VSHVINDAIPQDLSFFVHRVGRTGRNGLPGTAITL 345
Cdd:PRK04537 326 VKYVYNYDLPFDAEDYVHRIGRTARLGEEGDAISF 360
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
12-203 |
6.65e-52 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 173.53 E-value: 6.65e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 12 IREALKELKFTTPTEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIFQQLDEASDS-----VQAVITAPSRELATQIY 86
Cdd:cd17960 1 ILDVVAELGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVLEILLKRKANlkkgqVGALIISPTRELATQIY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 87 QVARQISAHSDVEVRVVNYVGGTDKARQIEKLESNQPHIVIGTPGRIYDLVKSGDLAIhKAKTF---VVDEADMTLDMGF 163
Cdd:cd17960 81 EVLQSFLEHHLPKLKCQLLIGGTNVEEDVKKFKRNGPNILVGTPGRLEELLSRKADKV-KVKSLevlVLDEADRLLDLGF 159
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 444285213 164 LETVDKIADSLPKDLQFMVFSATIPQKLQPFLKKYLSNPV 203
Cdd:cd17960 160 EADLNRILSKLPKQRRTGLFSATQTDAVEELIKAGLRNPV 199
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
14-203 |
8.51e-52 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 172.83 E-value: 8.51e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 14 EALKELKFTTPTEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIFQQLDEASDSVQAVITAPSRELATQIYQVARQIs 93
Cdd:cd17943 3 EGLKAAGFQRPSPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIALESLDLERRHPQVLILAPTREIAVQIHDVFKKI- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 94 AHSDVEVRVVNYVGGTDKARQIEKLesNQPHIVIGTPGRIYDLVKSGDLAIHKAKTFVVDEADMTLDMGFLETVDKIADS 173
Cdd:cd17943 82 GKKLEGLKCEVFIGGTPVKEDKKKL--KGCHIAVGTPGRIKQLIELGALNVSHVRLFVLDEADKLMEGSFQKDVNWIFSS 159
|
170 180 190
....*....|....*....|....*....|
gi 444285213 174 LPKDLQFMVFSATIPQKLQPFLKKYLSNPV 203
Cdd:cd17943 160 LPKNKQVIAFSATYPKNLDNLLARYMRKPV 189
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
12-199 |
5.29e-51 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 171.61 E-value: 5.29e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 12 IREALKELKFTTPTEVQDKLIPIVLA-GRDLVGESKTGSGKTHTFLLPIFQQL-----DEASDSVQAVITAPSRELATQI 85
Cdd:cd17964 5 LLKALTRMGFETMTPVQQKTLKPILStGDDVLARAKTGTGKTLAFLLPAIQSLlntkpAGRRSGVSALIISPTRELALQI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 86 YQVARQ-ISAHSDVEVRVVnyVGGTDKARQIEKLESNQPHIVIGTPGRIYDLVKSGDLAIH--KAKTFVVDEADMTLDMG 162
Cdd:cd17964 85 AAEAKKlLQGLRKLRVQSA--VGGTSRRAELNRLRRGRPDILVATPGRLIDHLENPGVAKAftDLDYLVLDEADRLLDMG 162
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 444285213 163 FLETVDKIADSLPK----DLQFMVFSATIPQKLQPFLKKYL 199
Cdd:cd17964 163 FRPDLEQILRHLPEknadPRQTLLFSATVPDEVQQIARLTL 203
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
2-204 |
2.01e-50 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 169.79 E-value: 2.01e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 2 SFTKFQFKNYIREALKELKFTTPTEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIFQQLDEASDSV--QAVITAPSR 79
Cdd:cd17959 2 GFQSMGLSPPLLRAIKKKGYKVPTPIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPMIEKLKAHSPTVgaRALILSPTR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 80 ELATQIYQVARQISAHSDVevRVVNYVGGTDKARQIEKLESNqPHIVIGTPGRIYDLVKSGDLAIHKAKTFVVDEADMTL 159
Cdd:cd17959 82 ELALQTLKVTKELGKFTDL--RTALLVGGDSLEEQFEALASN-PDIIIATPGRLLHLLVEMNLKLSSVEYVVFDEADRLF 158
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 444285213 160 DMGFLETVDKIADSLPKDLQFMVFSATIPQKLQPFLKKYLSNPVM 204
Cdd:cd17959 159 EMGFAEQLHEILSRLPENRQTLLFSATLPKLLVEFAKAGLNEPVL 203
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
25-192 |
4.67e-50 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 167.42 E-value: 4.67e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 25 TEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIFQQLDEASDSVQAVITAPSRELATQIYQVARQISAHSDVEVRVVn 104
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDNGPQALVLAPTRELAEQIYEELKKLGKGLGLKVASL- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 105 yVGGTDKARQIEKLESnqPHIVIGTPGRIYDLVKSGDLaIHKAKTFVVDEADMTLDMGFLETVDKIADSLPKDLQFMVFS 184
Cdd:pfam00270 80 -LGGDSRKEQLEKLKG--PDILVGTPGRLLDLLQERKL-LKNLKLLVLDEAHRLLDMGFGPDLEEILRRLPKKRQILLLS 155
|
....*...
gi 444285213 185 ATIPQKLQ 192
Cdd:pfam00270 156 ATLPRNLE 163
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
14-208 |
2.49e-49 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 166.72 E-value: 2.49e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 14 EALKELKFTTPTEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIFQQLDEASDSVQAVITAPSRELAtqiYQVARQIS 93
Cdd:cd17954 13 EACEKLGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALPILQALLENPQRFFALVLAPTRELA---QQISEQFE 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 94 A-HSDVEVRVVNYVGGTDKARQIEKLeSNQPHIVIGTPGRIYD-LVKSGDLAIHKAKTFVVDEADMTLDMGFLETVDKIA 171
Cdd:cd17954 90 AlGSSIGLKSAVLVGGMDMMAQAIAL-AKKPHVIVATPGRLVDhLENTKGFSLKSLKFLVMDEADRLLNMDFEPEIDKIL 168
|
170 180 190
....*....|....*....|....*....|....*..
gi 444285213 172 DSLPKDLQFMVFSATIPQKLQPFLKKYLSNPVmeKIK 208
Cdd:cd17954 169 KVIPRERTTYLFSATMTTKVAKLQRASLKNPV--KIE 203
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
1-343 |
3.07e-49 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 175.36 E-value: 3.07e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 1 MSFTKFQFKNYIREALKELKFTTPTEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIFQ-----QLDEASDSVQ--AV 73
Cdd:PLN00206 121 LSFSSCGLPPKLLLNLETAGYEFPTPIQMQAIPAALSGRSLLVSADTGSGKTASFLVPIISrcctiRSGHPSEQRNplAM 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 74 ITAPSRELATQIYQVARQISAHSDVEVRVVnyVGGTDKARQIEKLEsNQPHIVIGTPGRIYDLVKSGDLAIHKAKTFVVD 153
Cdd:PLN00206 201 VLTPTRELCVQVEDQAKVLGKGLPFKTALV--VGGDAMPQQLYRIQ-QGVELIVGTPGRLIDLLSKHDIELDNVSVLVLD 277
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 154 EADMTLDMGFLETVDKIADSLPKDlQFMVFSATIPQKLQPFLKKYLSNPVMEKIKTKTVISDTIDNWLISTKGHDKNAQI 233
Cdd:PLN00206 278 EVDCMLERGFRDQVMQIFQALSQP-QVLLFSATVSPEVEKFASSLAKDIILISIGNPNRPNKAVKQLAIWVETKQKKQKL 356
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 234 YQLTQSMQPYL--AMIFVNTKTRADELHSYLT-AQGLKVAKIHGDIAPRERKRIMNQVQNLDFEYIVATDLAARGIDIEG 310
Cdd:PLN00206 357 FDILKSKQHFKppAVVFVSSRLGADLLANAITvVTGLKALSIHGEKSMKERREVMKSFLVGEVPVIVATGVLGRGVDLLR 436
|
330 340 350
....*....|....*....|....*....|...
gi 444285213 311 VSHVINDAIPQDLSFFVHRVGRTGRNGLPGTAI 343
Cdd:PLN00206 437 VRQVIIFDMPNTIKEYIHQIGRASRMGEKGTAI 469
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
14-203 |
1.24e-48 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 165.09 E-value: 1.24e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 14 EALKELKFTTPTEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIFQQLDEASDSVQAVITAPSRELAtqiYQVARQIS 93
Cdd:cd17955 12 KQCASLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALPILQRLSEDPYGIFALVLTPTRELA---YQIAEQFR 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 94 AH-SDVEVRVVNYVGGTDKARQIEKLeSNQPHIVIGTPGRIYDLVKSGDLAI---HKAKTFVVDEADMTLDMGFLETVDK 169
Cdd:cd17955 89 ALgAPLGLRCCVIVGGMDMVKQALEL-SKRPHIVVATPGRLADHLRSSDDTTkvlSRVKFLVLDEADRLLTGSFEDDLAT 167
|
170 180 190
....*....|....*....|....*....|....
gi 444285213 170 IADSLPKDLQFMVFSATIPQKLQPFLKKYLSNPV 203
Cdd:cd17955 168 ILSALPPKRQTLLFSATLTDALKALKELFGNKPF 201
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
15-207 |
1.70e-48 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 164.68 E-value: 1.70e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 15 ALKELKFTTPTEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIFQQLDEASDS------VQAVITAPSRELATQIYQV 88
Cdd:cd17961 8 AIAKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIQKILKAKAEsgeeqgTRALILVPTRELAQQVSKV 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 89 ARQISAHSDVEVRVVNYVGGTDKARQIEKLeSNQPHIVIGTPGRIYDLVKSGDLAI-HKAKTFVVDEADMTLDMGFLETV 167
Cdd:cd17961 88 LEQLTAYCRKDVRVVNLSASSSDSVQRALL-AEKPDIVVSTPARLLSHLESGSLLLlSTLKYLVIDEADLVLSYGYEEDL 166
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 444285213 168 DKIADSLPKDLQFMVFSATIPQKLQPFLKKYLSNPVMEKI 207
Cdd:cd17961 167 KSLLSYLPKNYQTFLMSATLSEDVEALKKLVLHNPAILKL 206
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
16-212 |
5.34e-48 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 163.43 E-value: 5.34e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 16 LKELKFTTPTEVQDKLIPIVLAG-RDLVGESKTGSGKTHTFLLPIFQQLDEaSDSVQAVITAPSRELATQIYQVARQISA 94
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEALKR-GKGGRVLVLVPTRELAEQWAEELKKLGP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 95 HSDVevRVVNYVGGTDKARQIEKLESNQPHIVIGTPGRIYDLVKSGDLAIHKAKTFVVDEADMTLDMGFLETVDKIADSL 174
Cdd:smart00487 80 SLGL--KVVGLYGGDSKREQLRKLESGKTDILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRLLDGGFGDQLEKLLKLL 157
|
170 180 190
....*....|....*....|....*....|....*...
gi 444285213 175 PKDLQFMVFSATIPQKLQPFLKKYLSNPVMEKIKTKTV 212
Cdd:smart00487 158 PKNVQLLLLSATPPEEIENLLELFLNDPVFIDVGFTPL 195
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
2-199 |
5.40e-48 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 163.81 E-value: 5.40e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 2 SFTKFQFKNYIREALKELKFTTPTEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIFQQL----DEASDSV------Q 71
Cdd:cd17967 1 SFEEAGLRELLLENIKRAGYTKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPIISKLledgPPSVGRGrrkaypS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 72 AVITAPSRELATQIYQVARQISAHSDVEVRVVnYvGGTDKARQIEKLEsNQPHIVIGTPGRIYDLVKSGDLAIHKAKTFV 151
Cdd:cd17967 81 ALILAPTRELAIQIYEEARKFSYRSGVRSVVV-Y-GGADVVHQQLQLL-RGCDILVATPGRLVDFIERGRISLSSIKFLV 157
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 444285213 152 VDEADMTLDMGFLETVDKIA---DSLPKDL-QFMVFSATIP---QKL-QPFLKKYL 199
Cdd:cd17967 158 LDEADRMLDMGFEPQIRKIVehpDMPPKGErQTLMFSATFPreiQRLaADFLKNYI 213
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
15-203 |
9.09e-47 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 159.73 E-value: 9.09e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 15 ALKELKFTTPTEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIFQQL---DEASDSVQAVITAPSRELATQIYQVARQ 91
Cdd:cd17947 4 ALSSLGFTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPILERLlyrPKKKAATRVLVLVPTRELAMQCFSVLQQ 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 92 ISAHSDVEVRVVnyVGGTDKARQIEKLESnQPHIVIGTPGRIYDLVK-SGDLAIHKAKTFVVDEADMTLDMGFLETVDKI 170
Cdd:cd17947 84 LAQFTDITFALA--VGGLSLKAQEAALRA-RPDIVIATPGRLIDHLRnSPSFDLDSIEILVLDEADRMLEEGFADELKEI 160
|
170 180 190
....*....|....*....|....*....|...
gi 444285213 171 ADSLPKDLQFMVFSATIPQKLQPFLKKYLSNPV 203
Cdd:cd17947 161 LRLCPRTRQTMLFSATMTDEVKDLAKLSLNKPV 193
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
15-203 |
1.04e-45 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 157.07 E-value: 1.04e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 15 ALKELKFTTPTEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIFQQLD----EASDSVQAVITAPSRELATQIYQVAR 90
Cdd:cd17941 4 GLKEAGFIKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLEKLYrerwTPEDGLGALIISPTRELAMQIFEVLR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 91 QISAHSDVEVRVVnyVGGTDKarQIEKLESNQPHIVIGTPGRIYD-LVKSGDLAIHKAKTFVVDEADMTLDMGFLETVDK 169
Cdd:cd17941 84 KVGKYHSFSAGLI--IGGKDV--KEEKERINRMNILVCTPGRLLQhMDETPGFDTSNLQMLVLDEADRILDMGFKETLDA 159
|
170 180 190
....*....|....*....|....*....|....
gi 444285213 170 IADSLPKDLQFMVFSATIPQKLQPFLKKYLSNPV 203
Cdd:cd17941 160 IVENLPKSRQTLLFSATQTKSVKDLARLSLKNPE 193
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
2-204 |
1.61e-44 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 154.43 E-value: 1.61e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 2 SFTKFQFKNYIREALKELKFTTPTEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIFQQLDEASDSVQAVITAPSREL 81
Cdd:cd17950 3 GFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTLQQLEPVDGQVSVLVICHTREL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 82 ATQIYQVARQISAH-SDVEVRVVnyVGGTDKARQIEKLESNQPHIVIGTPGRIYDLVKSGDLAIHKAKTFVVDEADM--- 157
Cdd:cd17950 83 AFQISNEYERFSKYmPNVKTAVF--FGGVPIKKDIEVLKNKCPHIVVGTPGRILALVREKKLKLSHVKHFVLDECDKmle 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 444285213 158 TLDMgfLETVDKIADSLPKDLQFMVFSATIPQKLQPFLKKYLSNPVM 204
Cdd:cd17950 161 QLDM--RRDVQEIFRATPHDKQVMMFSATLSKEIRPVCKKFMQDPLE 205
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
12-203 |
2.60e-44 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 154.46 E-value: 2.60e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 12 IREALKELKFTTPTEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIFQQLD-----EASDSVQAVITAPSRELATQIY 86
Cdd:cd17953 23 VLDLIKKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFRHIKdqrpvKPGEGPIGLIMAPTRELALQIY 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 87 QVARQISahSDVEVRVVNYVGGTDKARQIEKLESNQpHIVIGTPGRIYDLV--KSGDLAIHKAKTFVV-DEADMTLDMGF 163
Cdd:cd17953 103 VECKKFS--KALGLRVVCVYGGSGISEQIAELKRGA-EIVVCTPGRMIDILtaNNGRVTNLRRVTYVVlDEADRMFDMGF 179
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 444285213 164 LETVDKIADSLPKDLQFMVFSATIPQKLQPFLKKYLSNPV 203
Cdd:cd17953 180 EPQIMKIVNNIRPDRQTVLFSATFPRKVEALARKVLHKPI 219
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
1-199 |
2.62e-44 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 155.51 E-value: 2.62e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 1 MSFTKFQFKNYIREALKELKFTTPTEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIFQQL----DEASD-----SVQ 71
Cdd:cd18052 43 LTFEEANLCETLLKNIRKAGYEKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPVLTGMmkegLTASSfsevqEPQ 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 72 AVITAPSRELATQIYQVARQISAHSDVEVrVVNYvGGTDKARQIEKLESNqPHIVIGTPGRIYDLVKSGDLAIHKAKTFV 151
Cdd:cd18052 123 ALIVAPTRELANQIFLEARKFSYGTCIRP-VVVY-GGVSVGHQIRQIEKG-CHILVATPGRLLDFIGRGKISLSKLKYLI 199
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 444285213 152 VDEADMTLDMGFLETVDKIADSL---PK-DLQFMVFSATIPQKLQ----PFLKK-YL 199
Cdd:cd18052 200 LDEADRMLDMGFGPEIRKLVSEPgmpSKeDRQTLMFSATFPEEIQrlaaEFLKEdYL 256
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
12-203 |
3.63e-44 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 153.29 E-value: 3.63e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 12 IREALKELKFTTPTEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIF-----QQLDEASDSVQAVITAPSRELATQIY 86
Cdd:cd17966 1 VMDELKRQGFTEPTAIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPAIvhinaQPPLERGDGPIVLVLAPTRELAQQIQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 87 QVARQISAHSDVEVRVVnyVGGTDKARQIEKLESNqPHIVIGTPGRIYDLVKSGDLAIHKAKTFVVDEADMTLDMGFLET 166
Cdd:cd17966 81 QEANKFGGSSRLRNTCV--YGGAPKGPQIRDLRRG-VEICIATPGRLIDFLDQGKTNLRRVTYLVLDEADRMLDMGFEPQ 157
|
170 180 190
....*....|....*....|....*....|....*..
gi 444285213 167 VDKIADSLPKDLQFMVFSATIPQKLQPFLKKYLSNPV 203
Cdd:cd17966 158 IRKIVDQIRPDRQTLMWSATWPKEVRRLAEDFLKDYI 194
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
12-204 |
3.91e-43 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 151.32 E-value: 3.91e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 12 IREALKELKFTTPTEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIFQQLDEA--------SDSVQAVITAPSRELAT 83
Cdd:cd17945 1 LLRVIRKLGYKEPTPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIPLLVYISRLppldeetkDDGPYALILAPTRELAQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 84 QIYQVARQISAHSDveVRVVNYVGGTDKARQIEKLeSNQPHIVIGTPGRIYDLVKSGDLAIHKAKTFVVDEADMTLDMGF 163
Cdd:cd17945 81 QIEEETQKFAKPLG--IRVVSIVGGHSIEEQAFSL-RNGCEILIATPGRLLDCLERRLLVLNQCTYVVLDEADRMIDMGF 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 444285213 164 LETVDKIADSLPKDL--------------------QFMVFSATIPQKLQPFLKKYLSNPVM 204
Cdd:cd17945 158 EPQVTKILDAMPVSNkkpdteeaeklaasgkhryrQTMMFTATMPPAVEKIAKGYLRRPVV 218
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
21-203 |
4.06e-43 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 150.55 E-value: 4.06e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 21 FTTPTEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIFQQLDEASDSVQAVITAPSRELATQIYQVARQISAHSDVEV 100
Cdd:cd17939 17 FEKPSAIQQRAIVPIIKGRDVIAQAQSGTGKTATFSIGALQRIDTTVRETQALVLAPTRELAQQIQKVVKALGDYMGVKV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 101 RVvnYVGGTDKARQIEKLESNqPHIVIGTPGRIYDLVKSGDLAIHKAKTFVVDEADMTLDMGFLETVDKIADSLPKDLQF 180
Cdd:cd17939 97 HA--CIGGTSVREDRRKLQYG-PHIVVGTPGRVFDMLQRRSLRTDKIKMFVLDEADEMLSRGFKDQIYDIFQFLPPETQV 173
|
170 180
....*....|....*....|...
gi 444285213 181 MVFSATIPQKLQPFLKKYLSNPV 203
Cdd:cd17939 174 VLFSATMPHEVLEVTKKFMRDPV 196
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
217-346 |
6.88e-43 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 147.27 E-value: 6.88e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 217 IDNWLISTKGHDKNAQIY-QLTQSMQPYLAMIFVNTKTRADELHSYLTAQGLKVAKIHGDIAPRERKRIMNQVQNLDFEY 295
Cdd:cd18787 1 IKQLYVVVEEEEKKLLLLlLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVRV 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 444285213 296 IVATDLAARGIDIEGVSHVINDAIPQDLSFFVHRVGRTGRNGLPGTAITLY 346
Cdd:cd18787 81 LVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
16-204 |
1.36e-42 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 148.89 E-value: 1.36e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 16 LKELKFTTPTEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIFQQLDE--ASDSVQAVITAPSRELATQIYQVARQIS 93
Cdd:cd17957 5 LEESGYREPTPIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILQKLGKprKKKGLRALILAPTRELASQIYRELLKLS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 94 AHSDVEVRVVNYvGGTDKARQIEKLeSNQPHIVIGTPGRIYDLVKSGDLAIHKAKTFVVDEADMTLDMGFLETVDKIADS 173
Cdd:cd17957 85 KGTGLRIVLLSK-SLEAKAKDGPKS-ITKYDILVSTPLRLVFLLKQGPIDLSSVEYLVLDEADKLFEPGFREQTDEILAA 162
|
170 180 190
....*....|....*....|....*....|..
gi 444285213 174 LP-KDLQFMVFSATIPQKLQPFLKKYLSNPVM 204
Cdd:cd17957 163 CTnPNLQRSLFSATIPSEVEELARSVMKDPIR 194
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
2-201 |
1.78e-42 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 150.19 E-value: 1.78e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 2 SFTKFQFKNYIREALKELKFTTPTEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIFQQLDE-------ASDSVQ--- 71
Cdd:cd18051 22 TFSDLDLGEIIRNNIELARYTKPTPVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLPILSQIYEqgpgeslPSESGYygr 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 72 ------AVITAPSRELATQIYQVARQISAHSDVEVRVVnYvGGTDKARQIEKLESNqPHIVIGTPGRIYDLVKSGDLAIH 145
Cdd:cd18051 102 rkqyplALVLAPTRELASQIYDEARKFAYRSRVRPCVV-Y-GGADIGQQMRDLERG-CHLLVATPGRLVDMLERGKIGLD 178
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 146 KAKTFVVDEADMTLDMGFLETVDKIA--DSLPK--DLQFMVFSATIPQKLQPFLKKYLSN 201
Cdd:cd18051 179 YCKYLVLDEADRMLDMGFEPQIRRIVeqDTMPPtgERQTLMFSATFPKEIQMLARDFLDN 238
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
12-205 |
8.42e-42 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 147.08 E-value: 8.42e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 12 IREALKELKFTTPTEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIFQqldeasdSVQAVITAPSRELATQIYQVARQ 91
Cdd:cd17938 10 LIKAVEELDWLLPTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVLQ-------IVVALILEPSRELAEQTYNCIEN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 92 ISAH-SDVEVRVVNYVGGTDKARQIEKLESNQpHIVIGTPGRIYDLVKSGDLAIHKAKTFVVDEADMTLDMGFLETVDKI 170
Cdd:cd17938 83 FKKYlDNPKLRVALLIGGVKAREQLKRLESGV-DIVVGTPGRLEDLIKTGKLDLSSVRFFVLDEADRLLSQGNLETINRI 161
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 444285213 171 ADSLPK------DLQFMVFSATipqkLQPFLKKYLSNPVME 205
Cdd:cd17938 162 YNRIPKitsdgkRLQVIVCSAT----LHSFEVKKLADKIMH 198
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
21-203 |
9.70e-41 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 144.13 E-value: 9.70e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 21 FTTPTEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIFQQLDEASDSVQAVITAPSRELATQIYQVARQISAHSDVEV 100
Cdd:cd18046 19 FEKPSAIQQRAIMPCIKGYDVIAQAQSGTGKTATFSISILQQIDTSLKATQALVLAPTRELAQQIQKVVMALGDYMGIKC 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 101 RVVnyVGGTDKARQIEKLESNqPHIVIGTPGRIYDLVKSGDLAIHKAKTFVVDEADMTLDMGFLETVDKIADSLPKDLQF 180
Cdd:cd18046 99 HAC--IGGTSVRDDAQKLQAG-PHIVVGTPGRVFDMINRRYLRTDYIKMFVLDEADEMLSRGFKDQIYDIFQKLPPDTQV 175
|
170 180
....*....|....*....|...
gi 444285213 181 MVFSATIPQKLQPFLKKYLSNPV 203
Cdd:cd18046 176 VLLSATMPNDVLEVTTKFMRDPI 198
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
15-192 |
1.46e-40 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 143.65 E-value: 1.46e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 15 ALKELKFTTPTEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIFQQLDEAS----DSVQAVITAPSRELATQIYQVAR 90
Cdd:cd17942 4 AIEEMGFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPAIELLYKLKfkprNGTGVIIISPTRELALQIYGVAK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 91 QISAHSDVEVRVVnyVGGTDKARQIEKLESNQPhIVIGTPGRIYD-LVKSGDLAIHKAKTFVVDEADMTLDMGFLETVDK 169
Cdd:cd17942 84 ELLKYHSQTFGIV--IGGANRKAEAEKLGKGVN-ILVATPGRLLDhLQNTKGFLYKNLQCLIIDEADRILEIGFEEEMRQ 160
|
170 180
....*....|....*....|...
gi 444285213 170 IADSLPKDLQFMVFSATIPQKLQ 192
Cdd:cd17942 161 IIKLLPKRRQTMLFSATQTRKVE 183
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
12-203 |
9.34e-40 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 141.71 E-value: 9.34e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 12 IREALKELKFTTPTEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLP-IFQQLDE-------ASDSVQAVITAPSRELAT 83
Cdd:cd17951 1 ILKGLKKKGIKKPTPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPlIMFALEQekklpfiKGEGPYGLIVCPSRELAR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 84 QIYQVARQISAHSDV----EVRVVNYVGGTDKARQIEKLeSNQPHIVIGTPGRIYDLVKSGDLAIHKAKTFVVDEADMTL 159
Cdd:cd17951 81 QTHEVIEYYCKALQEggypQLRCLLCIGGMSVKEQLEVI-RKGVHIVVATPGRLMDMLNKKKINLDICRYLCLDEADRMI 159
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 444285213 160 DMGFLETVDKIADSLPKDLQFMVFSATIPQKLQPFLKKYLSNPV 203
Cdd:cd17951 160 DMGFEEDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPV 203
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
12-203 |
5.52e-39 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 139.47 E-value: 5.52e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 12 IREALKELKFTTPTEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIF-----QQLDEASDSVQAVITAPSRELATQIY 86
Cdd:cd17952 1 LLNAIRKQEYEQPTPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPMLvhimdQRELEKGEGPIAVIVAPTRELAQQIY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 87 QVARQISAHSDVEVRVVnyVGGTDKARQIEKLESNqPHIVIGTPGRIYDLVKSGDLAIHKAKTFVVDEADMTLDMGFLET 166
Cdd:cd17952 81 LEAKKFGKAYNLRVVAV--YGGGSKWEQAKALQEG-AEIVVATPGRLIDMVKKKATNLQRVTYLVLDEADRMFDMGFEYQ 157
|
170 180 190
....*....|....*....|....*....|....*..
gi 444285213 167 VDKIADSLPKDLQFMVFSATIPQKLQPFLKKYLSNPV 203
Cdd:cd17952 158 VRSIVGHVRPDRQTLLFSATFKKKIEQLARDILSDPI 194
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
16-203 |
1.18e-38 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 138.45 E-value: 1.18e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 16 LKELKFTTPTEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIFQQLDEASDSVQAVITAPSRELATQIYQVARQISAh 95
Cdd:cd17962 5 LKKAGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRCLTEHRNPSALILTPTRELAVQIEDQAKELMK- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 96 SDVEVRVVNYVGGTDKARQIEKLESNQpHIVIGTPGRIYDLVKSGDLAIHKAKTFVVDEADMTLDMGFLETVDKIADSLP 175
Cdd:cd17962 84 GLPPMKTALLVGGLPLPPQLYRLQQGV-KVIIATPGRLLDILKQSSVELDNIKIVVVDEADTMLKMGFQQQVLDILENIS 162
|
170 180
....*....|....*....|....*...
gi 444285213 176 KDLQFMVFSATIPQKLQPFLKKYLSNPV 203
Cdd:cd17962 163 HDHQTILVSATIPRGIEQLAGQLLQNPV 190
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
15-203 |
3.42e-38 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 137.32 E-value: 3.42e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 15 ALKELKFTTPTEVQDKLIPIVLAG--RDLVGESKTGSGKTHTFLLPIFQQLDEASDSVQAVITAPSRELATQIYQVARQI 92
Cdd:cd17963 8 GLYAMGFNKPSKIQETALPLILSDppENLIAQSQSGTGKTAAFVLAMLSRVDPTLKSPQALCLAPTRELARQIGEVVEKM 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 93 SAHSDVEVRVVnyVGGTDKARQiEKLESnqpHIVIGTPGRIYDLVKSGDLAIHKAKTFVVDEADMTLDM-GFLETVDKIA 171
Cdd:cd17963 88 GKFTGVKVALA--VPGNDVPRG-KKITA---QIVIGTPGTVLDWLKKRQLDLKKIKILVLDEADVMLDTqGHGDQSIRIK 161
|
170 180 190
....*....|....*....|....*....|..
gi 444285213 172 DSLPKDLQFMVFSATIPQKLQPFLKKYLSNPV 203
Cdd:cd17963 162 RMLPRNCQILLFSATFPDSVRKFAEKIAPNAN 193
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
21-203 |
2.83e-37 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 134.90 E-value: 2.83e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 21 FTTPTEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIFQQLDEASDSVQAVITAPSRELATQIYQVARQISAHSDVEV 100
Cdd:cd18045 19 FEKPSAIQQRAIKPIIKGRDVIAQSQSGTGKTATFSISVLQCLDIQVRETQALILSPTRELAVQIQKVLLALGDYMNVQC 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 101 RVVnyVGGTDKARQIEKLESNQpHIVIGTPGRIYDLVKSGDLAIHKAKTFVVDEADMTLDMGFLETVDKIADSLPKDLQF 180
Cdd:cd18045 99 HAC--IGGTSVGDDIRKLDYGQ-HIVSGTPGRVFDMIRRRSLRTRHIKMLVLDEADEMLNKGFKEQIYDVYRYLPPATQV 175
|
170 180
....*....|....*....|...
gi 444285213 181 MVFSATIPQKLQPFLKKYLSNPV 203
Cdd:cd18045 176 VLVSATLPQDILEMTNKFMTDPI 198
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
1-199 |
5.94e-37 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 135.14 E-value: 5.94e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 1 MSFTKFQFKNYIREALKELKFTTPTEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIF-----QQLDEASDSVQAVIT 75
Cdd:cd18049 24 LNFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIvhinhQPFLERGDGPICLVL 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 76 APSRELATQIYQVARQISAHSdvEVRVVNYVGGTDKARQIEKLESNQpHIVIGTPGRIYDLVKSGDLAIHKAKTFVVDEA 155
Cdd:cd18049 104 APTRELAQQVQQVAAEYGRAC--RLKSTCIYGGAPKGPQIRDLERGV-EICIATPGRLIDFLEAGKTNLRRCTYLVLDEA 180
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 444285213 156 DMTLDMGFLETVDKIADSLPKDLQFMVFSATIPQKL----QPFLKKYL 199
Cdd:cd18049 181 DRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVrqlaEDFLKDYI 228
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
2-203 |
5.00e-36 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 133.98 E-value: 5.00e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 2 SFTKFQFKNYIREALKELKFTTPTEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIFQQLD-----EASDSVQAVITA 76
Cdd:cd18050 63 AFHQANFPQYVMDVLLDQNFKEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINhqpylERGDGPICLVLA 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 77 PSRELATQIYQVARQISAHSDVEVRVVnyVGGTDKARQIEKLESNQpHIVIGTPGRIYDLVKSGDLAIHKAKTFVVDEAD 156
Cdd:cd18050 143 PTRELAQQVQQVADDYGKSSRLKSTCI--YGGAPKGPQIRDLERGV-EICIATPGRLIDFLEAGKTNLRRCTYLVLDEAD 219
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 444285213 157 MTLDMGFLETVDKIADSLPKDLQFMVFSATIPQKLQPFLKKYLSNPV 203
Cdd:cd18050 220 RMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLRDYV 266
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
12-218 |
7.68e-36 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 132.36 E-value: 7.68e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 12 IREALKELKFTTPTEVQDKLIP-IVLAGRDLVGESKTGSGKTHTFLLPIFQQLDEASDS---------VQAVITAPSREL 81
Cdd:cd17946 1 ILRALADLGFSEPTPIQALALPaAIRDGKDVIGAAETGSGKTLAFGIPILERLLSQKSSngvggkqkpLRALILTPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 82 ATQIYQVARQISAHSDVevRVVNYVGGTDKARQiEKLESNQPHIVIGTPGRIYDLVKSGD--LA-IHKAKTFVVDEADMT 158
Cdd:cd17946 81 AVQVKDHLKAIAKYTNI--KIASIVGGLAVQKQ-ERLLKKRPEIVVATPGRLWELIQEGNehLAnLKSLRFLVLDEADRM 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 444285213 159 LDMGFLETVDKIADSLPKD-------LQFMVFSATIPQKLQPFLKKyLSNPVMEKIKTKTVISDTID 218
Cdd:cd17946 158 LEKGHFAELEKILELLNKDragkkrkRQTFVFSATLTLDHQLPLKL-NSKKKKKKKEKKQKLELLIE 223
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
12-204 |
3.15e-34 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 126.81 E-value: 3.15e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 12 IREALKELKFTTPTEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIFQQLD------EASDSVQAVITAPSRELATQI 85
Cdd:cd17958 1 IMKEIKKQGFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPGFIHLDlqpiprEQRNGPGVLVLTPTRELALQI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 86 YQvarQISAHSDVEVRVVNYVGGTDKARQIEKLESNqPHIVIGTPGRIYDLVKSGDLAIHKAKTFVVDEADMTLDMGFLE 165
Cdd:cd17958 81 EA---ECSKYSYKGLKSVCVYGGGNRNEQIEDLSKG-VDIIIATPGRLNDLQMNNVINLKSITYLVLDEADRMLDMGFEP 156
|
170 180 190
....*....|....*....|....*....|....*....
gi 444285213 166 TVDKIADSLPKDLQFMVFSATIPQKLQPFLKKYLSNPVM 204
Cdd:cd17958 157 QIRKILLDIRPDRQTIMTSATWPDGVRRLAQSYLKDPMI 195
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
14-209 |
3.05e-33 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 125.17 E-value: 3.05e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 14 EALKELKFTTPTEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIFQQL--DEASDSVQ-----AVITAPSRELATQIY 86
Cdd:cd17948 3 EILQRQGITKPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIQRLlrYKLLAEGPfnaprGLVITPSRELAEQIG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 87 QVARQISAHSDVEVRVVnyVGGTDKaRQIEKLESNQPHIVIGTPGRIYDLVKSGDLAIHKAKTFVVDEADMTLDMGFLET 166
Cdd:cd17948 83 SVAQSLTEGLGLKVKVI--TGGRTK-RQIRNPHFEEVDILVATPGALSKLLTSRIYSLEQLRHLVLDEADTLLDDSFNEK 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 444285213 167 VDKI-------------ADSLPKDLQFMVFSATIPQKLQPFLKKYLSNPVMEKIKT 209
Cdd:cd17948 160 LSHFlrrfplasrrsenTDGLDPGTQLVLVSATMPSGVGEVLSKVIDVDSIETVTS 215
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
19-206 |
2.45e-32 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 121.92 E-value: 2.45e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 19 LKFTTPTEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIFQQLDEASDSVQ------AVITAPSRELATQIYQVARQI 92
Cdd:cd17949 9 MGIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQRLLSLEPRVDrsdgtlALVLVPTRELALQIYEVLEKL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 93 sahsdveVR-----VVNYV-GGT----DKARqIEKLESnqphIVIGTPGRIYDLVKSGD-LAIHKAKTFVVDEADMTLDM 161
Cdd:cd17949 89 -------LKpfhwiVPGYLiGGEkrksEKAR-LRKGVN----ILIATPGRLLDHLKNTQsFDVSNLRWLVLDEADRLLDM 156
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 444285213 162 GFLETVDKI-------------ADSLPKDLQFMVFSATIPQKLQPFLKKYLSNPVMEK 206
Cdd:cd17949 157 GFEKDITKIlellddkrskaggEKSKPSRRQTVLVSATLTDGVKRLAGLSLKDPVYID 214
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
27-199 |
1.07e-27 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 109.17 E-value: 1.07e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 27 VQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIFQQLDEASD------SVQAVITAPSRELATQIYQVARQISAhsdvEV 100
Cdd:cd17944 16 IQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPLIEKLQEDQQprkrgrAPKVLVLAPTRELANQVTKDFKDITR----KL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 101 RVVNYVGGTDKARQIEKLEsNQPHIVIGTPGRIYDLVKSGDLAIHKAKTFVVDEADMTLDMGFLETVDKI-ADSLPKDL- 178
Cdd:cd17944 92 SVACFYGGTPYQQQIFAIR-NGIDILVGTPGRIKDHLQNGRLDLTKLKHVVLDEVDQMLDMGFAEQVEEIlSVSYKKDSe 170
|
170 180
....*....|....*....|....
gi 444285213 179 ---QFMVFSATIPQKLQPFLKKYL 199
Cdd:cd17944 171 dnpQTLLFSATCPDWVYNVAKKYM 194
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
228-337 |
1.06e-25 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 100.75 E-value: 1.06e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 228 DKNAQIYQLTQSMQPYLAMIFVNTKTRADElHSYLTAQGLKVAKIHGDIAPRERKRIMNQVQNLDFEYIVATDLAARGID 307
Cdd:pfam00271 1 EKLEALLELLKKERGGKVLIFSQTKKTLEA-ELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLD 79
|
90 100 110
....*....|....*....|....*....|
gi 444285213 308 IEGVSHVINDAIPQDLSFFVHRVGRTGRNG 337
Cdd:pfam00271 80 LPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
2-208 |
3.05e-25 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 103.18 E-value: 3.05e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 2 SFTKFQFKNYIREALKELKFTTPTEVQDKLIPIVLAG--RDLVGESKTGSGKTHTFLLPIFQQLDEASDSVQAVITAPSR 79
Cdd:cd18048 19 SFEELHLKEELLRGIYAMGFNRPSKIQENALPMMLADppQNLIAQSQSGTGKTAAFVLAMLSRVDALKLYPQCLCLSPTF 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 80 ELATQIYQVARQISAHSdVEVRVVNYVGGT--DKARQIEKlesnqpHIVIGTPGRIYD-LVKSGDLAIHKAKTFVVDEAD 156
Cdd:cd18048 99 ELALQTGKVVEEMGKFC-VGIQVIYAIRGNrpGKGTDIEA------QIVIGTPGTVLDwCFKLRLIDVTNISVFVLDEAD 171
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 444285213 157 MTLDM-GFLETVDKIADSLPKDLQFMVFSATIPQKLQPFLKKYLSNPVMEKIK 208
Cdd:cd18048 172 VMINVqGHSDHSVRVKRSMPKECQMLLFSATFEDSVWAFAERIVPDPNIIKLK 224
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
12-202 |
2.60e-24 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 100.40 E-value: 2.60e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 12 IREALKELKFTTPTEVQDKLIPIVLAG---------RDLVGESKTGSGKTHTFLLPIFQQLDEASD-SVQAVITAPSREL 81
Cdd:cd17956 1 LLKNLQNNGITSAFPVQAAVIPWLLPSskstppyrpGDLCVSAPTGSGKTLAYVLPIVQALSKRVVpRLRALIVVPTKEL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 82 ATQIYQVARQISAHSDveVRVVNYVGGTD---KARQIEKLESNQ----PHIVIGTPGRIYDLVKSGD-LAIHKAKTFVVD 153
Cdd:cd17956 81 VQQVYKVFESLCKGTG--LKVVSLSGQKSfkkEQKLLLVDTSGRylsrVDILVATPGRLVDHLNSTPgFTLKHLRFLVID 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 444285213 154 EADMTLDMGF---LETVDK-----------------IADSLPKDLQFMVFSATI---PQKLQpFLKkyLSNP 202
Cdd:cd17956 159 EADRLLNQSFqdwLETVMKalgrptapdlgsfgdanLLERSVRPLQKLLFSATLtrdPEKLS-SLK--LHRP 227
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
2-202 |
8.70e-22 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 92.86 E-value: 8.70e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 2 SFTKFQFKNYIREALKELKFTTPTEVQDKLIPIVLAG--RDLVGESKTGSGKTHTFLLPIFQQLDEASDSVQAVITAPSR 79
Cdd:cd18047 2 SFEELRLKPQLLQGVYAMGFNRPSKIQENALPLMLAEppQNLIAQSQSGTGKTAAFVLAMLSQVEPANKYPQCLCLSPTY 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 80 ELATQIYQVARQISAHSDvEVRVVNYVGGtdkaRQIEKLESNQPHIVIGTPGRIYD-LVKSGDLAIHKAKTFVVDEAD-M 157
Cdd:cd18047 82 ELALQTGKVIEQMGKFYP-ELKLAYAVRG----NKLERGQKISEQIVIGTPGTVLDwCSKLKFIDPKKIKVFVLDEADvM 156
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 444285213 158 TLDMGFLETVDKIADSLPKDLQFMVFSATIPQKLQPFLKKYLSNP 202
Cdd:cd18047 157 IATQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDP 201
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
256-337 |
1.31e-21 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 88.42 E-value: 1.31e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 256 DELHSYLTAQGLKVAKIHGDIAPRERKRIMNQVQNLDFEYIVATDLAARGIDIEGVSHVINDAIPQDLSFFVHRVGRTGR 335
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGR 80
|
..
gi 444285213 336 NG 337
Cdd:smart00490 81 AG 82
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
12-197 |
7.09e-17 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 80.11 E-value: 7.09e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 12 IREALKE------LKFTT---PTEVQDKLIPIVL---AGRDLVGESK-------------TGSGKTHTFLLPIFQQL--D 64
Cdd:cd17965 10 VREAIIKeilkgsNKTDEeikPSPIQTLAIKKLLktlMRKVTKQTSNeepklevfllaaeTGSGKTLAYLAPLLDYLkrQ 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 65 EASDS---------------VQAVITAPSRELATQIYQVARQISAHSDVEVRVVNYVGGTDKaRQIEKLESNQPHIVIGT 129
Cdd:cd17965 90 EQEPFeeaeeeyesakdtgrPRSVILVPTHELVEQVYSVLKKLSHTVKLGIKTFSSGFGPSY-QRLQLAFKGRIDILVTT 168
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 444285213 130 PGRIYDLVKSGDLAIHKAKTFVVDEADMTLDMGFLETVDKIADSLPKDLQFMVFSATIPQKLQPFLKK 197
Cdd:cd17965 169 PGKLASLAKSRPKILSRVTHLVVDEADTLFDRSFLQDTTSIIKRAPKLKHLILCSATIPKEFDKTLRK 236
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
44-186 |
4.05e-16 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 75.13 E-value: 4.05e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 44 ESKTGSGKTHTFLLPIFQQLDEASDsvQAVITAPSRELATQIYQVARQISAHSdveVRVVNYVGGTDKARQiEKLESNQP 123
Cdd:cd00046 7 TAPTGSGKTLAALLAALLLLLKKGK--KVLVLVPTKALALQTAERLRELFGPG---IRVAVLVGGSSAEER-EKNKLGDA 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 444285213 124 HIVIGTPGRIYDLVKSGDLA-IHKAKTFVVDEADMTLDMGFLETVDKIAD--SLPKDLQFMVFSAT 186
Cdd:cd00046 81 DIIIATPDMLLNLLLREDRLfLKDLKLIIVDEAHALLIDSRGALILDLAVrkAGLKNAQVILLSAT 146
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
247-346 |
2.16e-11 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 61.07 E-value: 2.16e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 247 IFVNTKTRADELHSYLTAQGLKVAKIHGDIAPRERKRIMNQVQNLDFEYIVATDLAARGIDIEGVSHVINDAIPQDLSFF 326
Cdd:cd18794 35 IYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWLRDKIQVIVATVAFGMGIDKPDVRFVIHYSLPKSMESY 114
|
90 100
....*....|....*....|
gi 444285213 327 VHRVGRTGRNGLPGTAITLY 346
Cdd:cd18794 115 YQESGRAGRDGLPSECILFY 134
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
2-444 |
2.28e-11 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 65.82 E-value: 2.28e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 2 SFTKFQFKNYIREALKELKFTTPTEvQDKLIpIVLAgrdlvgeskTGSGKTHTFLLPIfqqlDEASDSVQAVITAPSREL 81
Cdd:COG1061 75 SGTSFELRPYQQEALEALLAALERG-GGRGL-VVAP---------TGTGKTVLALALA----AELLRGKRVLVLVPRREL 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 82 ATQIYQVARqisahsdvevRVVNYVGGTDKARQIEKlesnqpHIVIGTpgriYDLVKSGDL--AIHKAKTFVV-DEADMT 158
Cdd:COG1061 140 LEQWAEELR----------RFLGDPLAGGGKKDSDA------PITVAT----YQSLARRAHldELGDRFGLVIiDEAHHA 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 159 LDMGFLETVDKI--------------ADSLPKDLQF---MVFSATIPQKL-QPFLKKY----LSNPVMEKIKTKTVISDT 216
Cdd:COG1061 200 GAPSYRRILEAFpaayrlgltatpfrSDGREILLFLfdgIVYEYSLKEAIeDGYLAPPeyygIRVDLTDERAEYDALSER 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 217 IDNWLIStkGHDKNAQIYQ--LTQSMQPYLAMIFVNTKTRADELHSYLTAQGLKVAKIHGDIAPRERKRIMNQVQNLDFE 294
Cdd:COG1061 280 LREALAA--DAERKDKILRelLREHPDDRKTLVFCSSVDHAEALAELLNEAGIRAAVVTGDTPKKEREEILEAFRDGELR 357
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 295 YIVATDLAARGIDIEGVSHVINDAIPQDLSFFVHRVGRTGRNGLPGTAITLYqpsD--DSDIRELEKLGIKFSPKMVKDG 372
Cdd:COG1061 358 ILVTVDVLNEGVDVPRLDVAILLRPTGSPREFIQRLGRGLRPAPGKEDALVY---DfvGNDVPVLEELAKDLRDLAGYRV 434
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 444285213 373 EFQDTYDRDRRANREKKQDKLDIEMIGLVKKKKKKVKPGYKKKIQWAVDEKRRKTKRAENRARGRAERKAKR 444
Cdd:COG1061 435 EFLDEEESEELALLIAVKPALEVKGELEEELLEELELLEDALLLVLAELLLLELLALALELLELAKAEGKAE 506
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
227-401 |
2.31e-11 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 65.55 E-value: 2.31e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 227 HDKNAQIYQLTQSMQPYLAMIFVNTKTRADELHSYLTAQGLKVAKIHGDIAPRERKRIMNQVQNLDFEYIVATdlAA--R 304
Cdd:COG0514 215 DDKLAQLLDFLKEHPGGSGIVYCLSRKKVEELAEWLREAGIRAAAYHAGLDAEEREANQDRFLRDEVDVIVAT--IAfgM 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 305 GIDIEGVSHVINDAIPQDLSFFVHRVGRTGRNGLPGTAITLYQPSDDsDIREleklgikfspKMVKDGEFqdtyDRDRRA 384
Cdd:COG0514 293 GIDKPDVRFVIHYDLPKSIEAYYQEIGRAGRDGLPAEALLLYGPEDV-AIQR----------FFIEQSPP----DEERKR 357
|
170
....*....|....*..
gi 444285213 385 NREKKQDkldiEMIGLV 401
Cdd:COG0514 358 VERAKLD----AMLAYA 370
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
232-350 |
1.20e-10 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 63.58 E-value: 1.20e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 232 QIYQLTQSMQPYLAMIFVNTKTRADELHSYLTAQGLKVAKIHGDIAPRERKRIMNQVQNLDFEYIVATDLAARGIDIEGV 311
Cdd:PRK11057 226 QLMRYVQEQRGKSGIIYCNSRAKVEDTAARLQSRGISAAAYHAGLDNDVRADVQEAFQRDDLQIVVATVAFGMGINKPNV 305
|
90 100 110
....*....|....*....|....*....|....*....
gi 444285213 312 SHVINDAIPQDLSFFVHRVGRTGRNGLPGTAITLYQPSD 350
Cdd:PRK11057 306 RFVVHFDIPRNIESYYQETGRAGRDGLPAEAMLFYDPAD 344
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
12-351 |
7.13e-10 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 61.00 E-value: 7.13e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 12 IREALKELKFTTPTEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIFQQLDEASDSvQAVITAPSRELATQIYQVARQ 91
Cdd:COG1205 45 LRAALKKRGIERLYSHQAEAIEAARAGKNVVIATPTASGKSLAYLLPVLEALLEDPGA-TALYLYPTKALARDQLRRLRE 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 92 ISAHSDVEVRVVNYVGGTDKA--RQIEKlesnQPHIVIGTPgriyDLVKSGDLAIHKA--------KTFVVDEA------ 155
Cdd:COG1205 124 LAEALGLGVRVATYDGDTPPEerRWIRE----HPDIVLTNP----DMLHYGLLPHHTRwarffrnlRYVVIDEAhtyrgv 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 156 ---DMTLdmgFLETVDKIADSLPKDLQFMVFSATI--PQKL------QPFL----------KKY--LSNP-VMEKIKTKT 211
Cdd:COG1205 196 fgsHVAN---VLRRLRRICRHYGSDPQFILASATIgnPAEHaerltgRPVTvvdedgsprgERTfvLWNPpLVDDGIRRS 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 212 VISDTIDnwLISTkghdknaqiyqLTQSMQPYLAmiFVNTKTRADELHSYLTAQ------GLKVAKIHGDIAPRERKRIM 285
Cdd:COG1205 273 ALAEAAR--LLAD-----------LVREGLRTLV--FTRSRRGAELLARYARRAlrepdlADRVAAYRAGYLPEERREIE 337
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 444285213 286 NQVQN--LDFeyIVAT---DLaarGIDIEGVSHVINDAIPQDLSFFVHRVGRTGRNGLPGTAITLyqPSDD 351
Cdd:COG1205 338 RGLRSgeLLG--VVSTnalEL---GIDIGGLDAVVLAGYPGTRASFWQQAGRAGRRGQDSLVVLV--AGDD 401
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
38-154 |
1.81e-09 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 56.44 E-value: 1.81e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 38 GRDLVGESKTGSGKTHTFLLPIFQQL-DEASDSVQAVITAPSRELATQIYQVARQISAHSDVEVRVVNYVGGT---DKAR 113
Cdd:cd17922 1 GRNVLIAAPTGSGKTEAAFLPALSSLaDEPEKGVQVLYISPLKALINDQERRLEEPLDEIDLEIPVAVRHGDTsqsEKAK 80
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 444285213 114 QIEKLesnqPHIVIGTPGRIYDLV--KSGDLAIHKAKTFVVDE 154
Cdd:cd17922 81 QLKNP----PGILITTPESLELLLvnKKLRELFAGLRYVVVDE 119
|
|
| Cas3_I |
cd09639 |
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short ... |
40-337 |
1.26e-07 |
|
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I
Pssm-ID: 187770 [Multi-domain] Cd Length: 353 Bit Score: 53.20 E-value: 1.26e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 40 DLVGESKTGSGKTHTFLLPIFQQLDEA-SDSVqaVITAPSRELATQIYQVARQI-----SAHSDVEVRVVNYVGGTDKAR 113
Cdd:cd09639 1 LLVIEAPTGYGKTEAALLWALHSLKSQkADRV--IIALPTRATINAMYRRAKEAfgetgLYHSSILSSRIKEMGDSEEFE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 114 QIEKLESNQPHIVIGTPGRIYD---LVKSGDLAIHKAKT---------FVVDEADMTLD--MGFLETV-DKIADslpKDL 178
Cdd:cd09639 79 HLFPLYIHSNDTLFLDPITVCTidqVLKSVFGEFGHYEFtlasianslLIFDEVHFYDEytLALILAVlEVLKD---NDV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 179 QFMVFSATIPQKLQPFLKKYLsnPVMEKiktKTVISDTIDNWLISTKGHDKNAQIYQLTQSMQPYLA----MIFVNTKTR 254
Cdd:cd09639 156 PILLMSATLPKFLKEYAEKIG--YVEEN---EPLDLKPNERAPFIKIESDKVGEISSLERLLEFIKKggsvAIIVNTVDR 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 255 ADELHSYLTAQGLKVAK--IHGDIAP--RERK--RIMNQVQNLDFEYIVATDLAARGIDIEgVSHVINDAIPQDLsfFVH 328
Cdd:cd09639 231 AQEFYQQLKEKGPEEEImlIHSRFTEkdRAKKeaELLLEFKKSEKFVIVATQVIEASLDIS-VDVMITELAPIDS--LIQ 307
|
....*....
gi 444285213 329 RVGRTGRNG 337
Cdd:cd09639 308 RLGRLHRYG 316
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
35-187 |
1.44e-07 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 51.43 E-value: 1.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 35 VLAGRDLVGESKTGSGKTHTFLLPIFQQLDEASdSVQAVITAPSRELATQIYQVARQISAHSDVEVRVVNYVGGTDKARQ 114
Cdd:cd17923 12 ARAGRSVVVTTGTASGKSLCYQLPILEALLRDP-GSRALYLYPTKALAQDQLRSLRELLEQLGLGIRVATYDGDTPREER 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 115 iEKLESNQPHIVIGTPGRI-YDLVKSGDLAIH---KAKTFVVDEA---------DMTLdmgFLETVDKIADSLPKDLQFM 181
Cdd:cd17923 91 -RAIIRNPPRILLTNPDMLhYALLPHHDRWARflrNLRYVVLDEAhtyrgvfgsHVAL---LLRRLRRLCRRYGADPQFI 166
|
....*.
gi 444285213 182 VFSATI 187
Cdd:cd17923 167 LTSATI 172
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
47-189 |
7.65e-07 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 49.18 E-value: 7.65e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 47 TGSGKTHTFLLPIFQQLdEASDSVqAVITAPSRELATQIYQVARQISAHSdvEVRVVNYVGGTdkarQIEKLESNQPHIV 126
Cdd:cd17921 26 TSSGKTLIAELAILRAL-ATSGGK-AVYIAPTRALVNQKEADLRERFGPL--GKNVGLLTGDP----SVNKLLLAEADIL 97
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 444285213 127 IGTPgRIYDLV--KSGDLAIHKAKTFVVDEADM--------TLDmgflETVDKIADSLPKdLQFMVFSATIPQ 189
Cdd:cd17921 98 VATP-EKLDLLlrNGGERLIQDVRLVVVDEAHLigdgergvVLE----LLLSRLLRINKN-ARFVGLSATLPN 164
|
|
| PRK13767 |
PRK13767 |
ATP-dependent helicase; Provisional |
11-130 |
1.07e-06 |
|
ATP-dependent helicase; Provisional
Pssm-ID: 237497 [Multi-domain] Cd Length: 876 Bit Score: 51.04 E-value: 1.07e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 11 YIREALKElKFTTPTEVQDKLIPIVLAGRDLVGESKTGSGKTHTFLLPIFQQL------DEASDSVQAVITAPSRELA-- 82
Cdd:PRK13767 21 YVREWFKE-KFGTFTPPQRYAIPLIHEGKNVLISSPTGSGKTLAAFLAIIDELfrlgreGELEDKVYCLYVSPLRALNnd 99
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 83 ---------TQIYQVARQISAHSDvEVRVVNYVGGT---DKARQIEKlesnQPHIVIGTP 130
Cdd:PRK13767 100 ihrnleeplTEIREIAKERGEELP-EIRVAIRTGDTssyEKQKMLKK----PPHILITTP 154
|
|
| SF2_C_UvrB |
cd18790 |
C-terminal helicase domain of the UvrB family helicases; Excinuclease ABC subunit B (or UvrB) ... |
251-336 |
2.84e-06 |
|
C-terminal helicase domain of the UvrB family helicases; Excinuclease ABC subunit B (or UvrB) plays a central role in nucleotide excision repair (NER). Together with other components of the NER system, like UvrA, UvrC, UvrD (helicase II), and DNA polymerase I, it recognizes and cleaves damaged DNA in a multistep ATP-dependent reaction. UvrB is critical for the second phase of damage recognition by verifying the nature of the damage and forming the pre-incision complex. Its ATPase site becomes activated in the presence of UvrA and damaged DNA. Its activity is strand destabilization via distortion of the DNA at lesion site, with very limited DNA unwinding. UvrB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350177 [Multi-domain] Cd Length: 171 Bit Score: 47.24 E-value: 2.84e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 251 TKTRADELHSYLTAQGLKVAKIHGDIAPRERKRIMNQVQNLDFEYIVATDLAARGIDIEGVSHV-INDA----IPQDLSF 325
Cdd:cd18790 36 TKRMAEDLTEYLQELGVKVRYLHSEIDTLERVEIIRDLRLGEFDVLVGINLLREGLDLPEVSLVaILDAdkegFLRSETS 115
|
90
....*....|.
gi 444285213 326 FVHRVGRTGRN 336
Cdd:cd18790 116 LIQTIGRAARN 126
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
279-346 |
1.78e-05 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 42.69 E-value: 1.78e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 444285213 279 RERKRIMNQvqnldFEYIVATDLAARGIDIEGVSHVINDAIPQDLSFFVHRVGRTGRNG-LPGTAITLY 346
Cdd:cd18785 14 EHAEEIASS-----LEILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGkDEGEVILFV 77
|
|
| DEXHc_RecG |
cd17918 |
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase ... |
12-154 |
3.39e-05 |
|
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase RecG family is part of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350676 [Multi-domain] Cd Length: 180 Bit Score: 44.33 E-value: 3.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 12 IREALKELKFTtPTEVQDKLIPIVLAG------RDLVGESKTGSGKTHTFLLPIFqqlDEASDSVQAVITAPSRELATQI 85
Cdd:cd17918 5 IQELCKSLPFS-LTKDQAQAIKDIEKDlhspepMDRLLSGDVGSGKTLVALGAAL---LAYKNGKQVAILVPTEILAHQH 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 444285213 86 YQVARQISAhsdvEVRVVNYVGGTDkarqiEKLESnQPHIVIGTPGRIYDLVKSGDLAIhkaktFVVDE 154
Cdd:cd17918 81 YEEARKFLP----FINVELVTGGTK-----AQILS-GISLLVGTHALLHLDVKFKNLDL-----VIVDE 134
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
11-130 |
3.43e-05 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 46.25 E-value: 3.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 11 YIREALKElKFTTPTEVQDKLIPIVLAGRD-LVgESKTGSGKTHTFLLPIFQQL------DEASDSVQAV-IT------- 75
Cdd:COG1201 13 AVRAWFAA-RFGAPTPPQREAWPAIAAGEStLL-IAPTGSGKTLAAFLPALDELarrprpGELPDGLRVLyISplkalan 90
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 444285213 76 -------APSRELATQIYQVARQISahsdVEVRvvnyVGGT---DKARQIEKLesnqPHIVIGTP 130
Cdd:COG1201 91 diernlrAPLEEIGEAAGLPLPEIR----VGVR----TGDTpasERQRQRRRP----PHILITTP 143
|
|
| SF2_C_LHR |
cd18796 |
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ... |
247-335 |
4.70e-05 |
|
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350183 [Multi-domain] Cd Length: 150 Bit Score: 43.41 E-value: 4.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 247 IFVNTKTRADELHSYL------TAQGLKVAKIHGDIAPRERKRIMNQVQNLDFEYIVAT---DLaarGIDIEGVSHVIND 317
Cdd:cd18796 43 VFTNTRSQAERLAQRLrelcpdRVPPDFIALHHGSLSRELREEVEAALKRGDLKVVVATsslEL---GIDIGDVDLVIQI 119
|
90
....*....|....*...
gi 444285213 318 AIPQDLSFFVHRVGRTGR 335
Cdd:cd18796 120 GSPKSVARLLQRLGRSGH 137
|
|
| DEXHc_archSki2 |
cd18028 |
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ... |
35-188 |
6.24e-05 |
|
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350786 [Multi-domain] Cd Length: 177 Bit Score: 43.48 E-value: 6.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 35 VLAGRDLVGESKTGSGKThtfLLPIFQQLDEASDSVQAVITAPSRELATQIYqvaRQISAHSDVEVRVVNYVGgtDKARQ 114
Cdd:cd18028 14 LLKGENLLISIPTASGKT---LIAEMAMVNTLLEGGKALYLVPLRALASEKY---EEFKKLEEIGLKVGISTG--DYDED 85
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 444285213 115 IEKLESNqpHIVIGTPGRIYDLVKSGDLAIHKAKTFVVDEADMTLDM---GFLETVDKIADSLPKDLQFMVFSATIP 188
Cdd:cd18028 86 DEWLGDY--DIIVATYEKFDSLLRHSPSWLRDVGVVVVDEIHLISDEergPTLESIVARLRRLNPNTQIIGLSATIG 160
|
|
| DEXHc_dicer |
cd18034 |
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ... |
47-155 |
1.20e-04 |
|
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350792 [Multi-domain] Cd Length: 200 Bit Score: 43.02 E-value: 1.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 47 TGSGKTHTFLLPI----FQQLDEASDSVQAVITAPSRELATQIYQVARQisaHSDVEVRVvnYVGGTDK---ARQIEKLE 119
Cdd:cd18034 25 TGSGKTLIAVMLIkemgELNRKEKNPKKRAVFLVPTVPLVAQQAEAIRS---HTDLKVGE--YSGEMGVdkwTKERWKEE 99
|
90 100 110
....*....|....*....|....*....|....*.
gi 444285213 120 SNQPHIVIGTPGRIYDLVKSGDLAIHKAKTFVVDEA 155
Cdd:cd18034 100 LEKYDVLVMTAQILLDALRHGFLSLSDINLLIFDEC 135
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
247-316 |
2.36e-04 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 40.92 E-value: 2.36e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 444285213 247 IFVNTKTRADELHSYLTAQGLKVAKIHGDIAPRERKRIMNQVQNLD--FEYIVATDLAARGIDIEGVSHVIN 316
Cdd:cd18793 32 IFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPdiRVFLLSTKAGGVGLNLTAANRVIL 103
|
|
| SF2_C_EcoAI-like |
cd18799 |
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family ... |
245-308 |
3.23e-04 |
|
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family is composed of helicase restriction enzymes, including the HsdR subunit of restriction-modification enzymes such as Escherichia coli type I restriction enzyme EcoAI R protein (R.EcoAI). The EcoAI enzyme recognizes 5'-GAGN(7)GTCA-3'. The HsdR or R subunit is required for both nuclease and ATPase activities, but not for modification. These proteins are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350186 [Multi-domain] Cd Length: 116 Bit Score: 40.24 E-value: 3.23e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 444285213 245 AMIFVNTKTRADELHSYLTAQGLKVAKIHGDIAPRER---KRIMNQVQNLDFEYIVATDLAARGIDI 308
Cdd:cd18799 9 TLIFCVSIEHAEFMAEAFNEAGIDAVALNSDYSDRERgdeALILLFFGELKPPILVTVDLLTTGVDI 75
|
|
| SF2_C_TRCF |
cd18810 |
C-terminal helicase domain of the transcription-repair coupling factor; Transcription-repair ... |
267-349 |
3.60e-04 |
|
C-terminal helicase domain of the transcription-repair coupling factor; Transcription-repair coupling factor (TrcF) dissociates transcription elongation complexes blocked at nonpairing lesions and mediates recruitment of DNA repair proteins. TrcF is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350197 [Multi-domain] Cd Length: 151 Bit Score: 40.79 E-value: 3.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 267 LKVAKIHGDIAPRERKRIMNQVQNLDFEYIVATDLAARGIDIEGVSH-VINDAIPQDLSFFVHRVGRTGRNGLPGTAITL 345
Cdd:cd18810 52 ARIAIAHGQMTENELEEVMLEFAKGEYDILVCTTIIESGIDIPNANTiIIERADKFGLAQLYQLRGRVGRSKERAYAYFL 131
|
....
gi 444285213 346 YQPS 349
Cdd:cd18810 132 YPDQ 135
|
|
| DEXHc_RecG |
cd17992 |
DEXH/Q-box helicase domain of RecG; ATP-dependent DNA helicase RecG plays a critical role in ... |
48-154 |
4.81e-04 |
|
DEXH/Q-box helicase domain of RecG; ATP-dependent DNA helicase RecG plays a critical role in recombination and DNA repair. It is a member of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350750 [Multi-domain] Cd Length: 225 Bit Score: 41.36 E-value: 4.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 48 GSGKThtfLLPIFQQLDEASDSVQAVITAPSRELATQIYQVARQISAHSDVEVRVV-NYVGGTDKARQIEKLESNQPHIV 126
Cdd:cd17992 76 GSGKT---VVAALAMLAAVENGYQVALMAPTEILAEQHYDSLKKLLEPLGIRVALLtGSTKAKEKREILEKIASGEIDIV 152
|
90 100
....*....|....*....|....*...
gi 444285213 127 IGTPGRIYDLVKSGDLAIhkaktFVVDE 154
Cdd:cd17992 153 IGTHALIQEDVEFHNLGL-----VIIDE 175
|
|
| SF2_C_Hrq |
cd18797 |
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role ... |
248-343 |
6.84e-04 |
|
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. HrQ family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350184 [Multi-domain] Cd Length: 146 Bit Score: 39.93 E-value: 6.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 248 FVNTKTRADELHSYLTAQGLKVAKIHGDIA-------PRERKRIMNQVQNLDFEYIVATDLAARGIDIEGVSHVINDAIP 320
Cdd:cd18797 41 FCRSRKLAELLLRYLKARLVEEGPLASKVAsyragylAEDRREIEAELFNGELLGVVATNALELGIDIGGLDAVVLAGYP 120
|
90 100
....*....|....*....|...
gi 444285213 321 QDLSFFVHRVGRTGRNGLPGTAI 343
Cdd:cd18797 121 GSLASLWQQAGRAGRRGKDSLVI 143
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
245-337 |
8.62e-04 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 41.64 E-value: 8.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 245 AMIFVNTKTRADELHSYLTAQGLKVAKIHGDiAPRERKRIMNQVQNL---------DFEYIVATDLAARGIDIEGVSHVI 315
Cdd:COG1111 356 IIVFTQYRDTAEMIVEFLSEPGIKAGRFVGQ-ASKEGDKGLTQKEQIeilerfragEFNVLVATSVAEEGLDIPEVDLVI 434
|
90 100
....*....|....*....|...
gi 444285213 316 N-DAIPQDLSfFVHRVGRTGRNG 337
Cdd:COG1111 435 FyEPVPSEIR-SIQRKGRTGRKR 456
|
|
| PLN03137 |
PLN03137 |
ATP-dependent DNA helicase; Q4-like; Provisional |
262-350 |
3.38e-03 |
|
ATP-dependent DNA helicase; Q4-like; Provisional
Pssm-ID: 215597 [Multi-domain] Cd Length: 1195 Bit Score: 39.88 E-value: 3.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 262 LTAQGLKVAKIHGDIAPRERKRIMNQVQNLDFEYIVATDLAARGIDIEGVSHVINDAIPQDLSFFVHRVGRTGRNGLPGT 341
Cdd:PLN03137 700 LQEFGHKAAFYHGSMDPAQRAFVQKQWSKDEINIICATVAFGMGINKPDVRFVIHHSLPKSIEGYHQECGRAGRDGQRSS 779
|
....*....
gi 444285213 342 AITLYQPSD 350
Cdd:PLN03137 780 CVLYYSYSD 788
|
|
| DDXDc_reverse_gyrase |
cd17924 |
DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of ... |
37-187 |
4.58e-03 |
|
DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. Reverse gyrase belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350682 [Multi-domain] Cd Length: 189 Bit Score: 38.08 E-value: 4.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 37 AGRDLVGES-----KTGSGKThTFLLPIfqQLDEASDSVQAVITAPSRELATQIYQVARQISAHSDVEVRVVNYVGGTDK 111
Cdd:cd17924 26 AKRLLRGKSfaiiaPTGVGKT-TFGLAT--SLYLASKGKRSYLIFPTKSLVKQAYERLSKYAEKAGVEVKILVYHSRLKK 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 112 ARQ---IEKLESNQPHIVIGTPGRIYDLVKSgdLAIHKAKTFVVDEADMTLDMGfletvdKIADSLPKDLQF---MVFSA 185
Cdd:cd17924 103 KEKeelLEKIEKGDFDILVTTNQFLSKNFDL--LSNKKFDFVFVDDVDAVLKSS------KNIDRLLKLLGFgqlVVSSA 174
|
..
gi 444285213 186 TI 187
Cdd:cd17924 175 TG 176
|
|
| PRK10917 |
PRK10917 |
ATP-dependent DNA helicase RecG; Provisional |
48-154 |
5.18e-03 |
|
ATP-dependent DNA helicase RecG; Provisional
Pssm-ID: 236794 [Multi-domain] Cd Length: 681 Bit Score: 39.36 E-value: 5.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 48 GSGKTHTFLLPIFQqldeASDS-VQAVITAPSRELATQIYQVARQISAHSDVEVRVVnyVGGT---DKARQIEKLESNQP 123
Cdd:PRK10917 292 GSGKTVVAALAALA----AIEAgYQAALMAPTEILAEQHYENLKKLLEPLGIRVALL--TGSLkgkERREILEAIASGEA 365
|
90 100 110
....*....|....*....|....*....|.
gi 444285213 124 HIVIGTPGRIYDLVKSGDLAIhkaktFVVDE 154
Cdd:PRK10917 366 DIVIGTHALIQDDVEFHNLGL-----VIIDE 391
|
|
| SF2_C_FANCM_Hef |
cd18801 |
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ... |
227-335 |
9.93e-03 |
|
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350188 [Multi-domain] Cd Length: 143 Bit Score: 36.56 E-value: 9.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285213 227 HDKNAQIYQLTQsmqpylAMIFVNTKTRADELHSYLTAQGLKV-AKIHGDIAPRERKRIMNQVQNLD---------FEYI 296
Cdd:cd18801 21 HFKKKQEGSDTR------VIIFSEFRDSAEEIVNFLSKIRPGIrATRFIGQASGKSSKGMSQKEQKEvieqfrkggYNVL 94
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 444285213 297 VATDLAARGIDIEGVSHVI-NDAIPQDLSfFVHRVGRTGR 335
Cdd:cd18801 95 VATSIGEEGLDIGEVDLIIcYDASPSPIR-MIQRMGRTGR 133
|
|
| |
