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Conserved domains on  [gi|444285229|gb|ELU90310|]
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transcriptional regulator, TetR family [Streptococcus pneumoniae PNI0360]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 11442335)

TetR/AcrR family transcriptional regulator controls genes involved in a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

CATH:  1.10.357.10
Gene Ontology:  GO:0003677|GO:0006355

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
25-123 8.24e-09

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


:

Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 52.21  E-value: 8.24e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285229  25 TREAIETALLQLLEKKELTKISISELVKRAGVSRAAFYRNYDSKEEILESVFKRTVHNIMEQLH----HYDLKTDLYLVW 100
Cdd:COG1309    7 TRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEealaAEDPRERLRALL 86

                         90       100
                 ....*....|....*....|...
gi 444285229 101 VHLFREARKEARVIQLALDYHLE 123
Cdd:COG1309   87 RAYLEFLAENPALARLLLAEAAE 109
TetR_C_8 pfam14278
Transcriptional regulator C-terminal region; This domain is a tetracycline repressor, domain 2, ...
 101-178 1.04e-05

Transcriptional regulator C-terminal region; This domain is a tetracycline repressor, domain 2, or C-terminus.


:

Pssm-ID: 464123  Cd Length: 103  Bit Score: 42.61  E-value: 1.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285229  101 VHLFREARKEARVIQLAL----DYHLEKIFVQAMQEFLEKY---HGKSKGVS----SYLHSFWSSAIVSVLLKWIKDGMK 169
Cdd:pfam14278   8 LKIFEYIKENKDFYRNLLssngRESFERYLYELTKELILGVveeLSEGMNVSeedkDFIADFYSYGFVGLILDWLENGMK 87


                  ....*....
gi 444285229  170 VPAEKIADL 178
Cdd:pfam14278  88 ESPEEIAEL 96
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
25-123 8.24e-09

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 52.21  E-value: 8.24e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285229  25 TREAIETALLQLLEKKELTKISISELVKRAGVSRAAFYRNYDSKEEILESVFKRTVHNIMEQLH----HYDLKTDLYLVW 100
Cdd:COG1309    7 TRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEealaAEDPRERLRALL 86

                         90       100
                 ....*....|....*....|...
gi 444285229 101 VHLFREARKEARVIQLALDYHLE 123
Cdd:COG1309   87 RAYLEFLAENPALARLLLAEAAE 109
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
46-75 9.91e-06

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 41.24  E-value: 9.91e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 444285229   46 SISELVKRAGVSRAAFYRNYDSKEEILESV 75
Cdd:pfam00440  18 TVREIAKRAGVSKGALYRYFGSKEELLEAL 47
TetR_C_8 pfam14278
Transcriptional regulator C-terminal region; This domain is a tetracycline repressor, domain 2, ...
 101-178 1.04e-05

Transcriptional regulator C-terminal region; This domain is a tetracycline repressor, domain 2, or C-terminus.


Pssm-ID: 464123  Cd Length: 103  Bit Score: 42.61  E-value: 1.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285229  101 VHLFREARKEARVIQLAL----DYHLEKIFVQAMQEFLEKY---HGKSKGVS----SYLHSFWSSAIVSVLLKWIKDGMK 169
Cdd:pfam14278   8 LKIFEYIKENKDFYRNLLssngRESFERYLYELTKELILGVveeLSEGMNVSeedkDFIADFYSYGFVGLILDWLENGMK 87


                  ....*....
gi 444285229  170 VPAEKIADL 178
Cdd:pfam14278  88 ESPEEIAEL 96
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
46-106 2.54e-04

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 39.89  E-value: 2.54e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 444285229  46 SISELVKRAGVSRAAFYRNYDSKEEILESVFK---RTVHNIMEQLHHYD---LKT--DLYLVWVHLFRE 106
Cdd:NF041196  28 TISDILERAGVTKGALYFHFSSKEALARAVLEeqvARLREAVEPQRAGGgskLQElvDLTHVLARRLRT 96
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
25-123 8.24e-09

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 52.21  E-value: 8.24e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285229  25 TREAIETALLQLLEKKELTKISISELVKRAGVSRAAFYRNYDSKEEILESVFKRTVHNIMEQLH----HYDLKTDLYLVW 100
Cdd:COG1309    7 TRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEealaAEDPRERLRALL 86

                         90       100
                 ....*....|....*....|...
gi 444285229 101 VHLFREARKEARVIQLALDYHLE 123
Cdd:COG1309   87 RAYLEFLAENPALARLLLAEAAE 109
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
46-75 9.91e-06

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 41.24  E-value: 9.91e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 444285229   46 SISELVKRAGVSRAAFYRNYDSKEEILESV 75
Cdd:pfam00440  18 TVREIAKRAGVSKGALYRYFGSKEELLEAL 47
TetR_C_8 pfam14278
Transcriptional regulator C-terminal region; This domain is a tetracycline repressor, domain 2, ...
 101-178 1.04e-05

Transcriptional regulator C-terminal region; This domain is a tetracycline repressor, domain 2, or C-terminus.


Pssm-ID: 464123  Cd Length: 103  Bit Score: 42.61  E-value: 1.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285229  101 VHLFREARKEARVIQLAL----DYHLEKIFVQAMQEFLEKY---HGKSKGVS----SYLHSFWSSAIVSVLLKWIKDGMK 169
Cdd:pfam14278   8 LKIFEYIKENKDFYRNLLssngRESFERYLYELTKELILGVveeLSEGMNVSeedkDFIADFYSYGFVGLILDWLENGMK 87


                  ....*....
gi 444285229  170 VPAEKIADL 178
Cdd:pfam14278  88 ESPEEIAEL 96
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
46-106 2.54e-04

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 39.89  E-value: 2.54e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 444285229  46 SISELVKRAGVSRAAFYRNYDSKEEILESVFK---RTVHNIMEQLHHYD---LKT--DLYLVWVHLFRE 106
Cdd:NF041196  28 TISDILERAGVTKGALYFHFSSKEALARAVLEeqvARLREAVEPQRAGGgskLQElvDLTHVLARRLRT 96
DUF6262 pfam19776
Family of unknown function (DUF6262); This family of proteins, functionally uncharacterized, ...
 44-87 9.20e-04

Family of unknown function (DUF6262); This family of proteins, functionally uncharacterized, is found in bacteria. Proteins in this family are typically between 124 and 143 amino acids in length. Some members included in this family are hypothetical transposases, associated with transposon Tn554. There is a conserved sequence GV/LSR/K and a highly conserved tyrosine residue.


Pssm-ID: 466180 [Multi-domain]  Cd Length: 110  Bit Score: 37.21  E-value: 9.20e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 444285229   44 KISISELVKRAGVSRAAFYRN-----------------YDSKEEILESVFKRTVHNIMEQL 87
Cdd:pfam19776  33 KITVPELVKRTGLSRGFFYKNpevrreldeaieqqggmVNPKREILDMALEKRIELLKKEI 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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