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Conserved domains on  [gi|444285231|gb|ELU90312|]
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flavoprotein family protein [Streptococcus pneumoniae PNI0360]

Protein Classification

NAD(P)/FAD-dependent oxidoreductase( domain architecture ID 12044987)

NAD(P)/FAD-dependent oxidoreductase catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant

CATH:  3.50.50.60
EC:  1.14.13.-
Gene Ontology:  GO:0050660|GO:0050661
SCOP:  4000073

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
HI0933_like pfam03486
HI0933-like protein;
4-387 0e+00

HI0933-like protein;


:

Pssm-ID: 427330 [Multi-domain]  Cd Length: 406  Bit Score: 560.66  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231    4 FDTIVIGGGPAGMMATISSSFYGQKTLLIEKNRKLGKKLAGTGGGRCNVTN-NGSLDNLLAGIPGNGRFLYSVFSQFDNH 82
Cdd:pfam03486   1 FDVIVIGGGAAGLMAAISAAKRGRRVLLIEKGKKLGRKILISGGGRCNVTNlSEEPDNFLSRYPGNPKFLKSALSRFTPW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231   83 DIINFFTENGVKLKVEDHGRVFPASDKSRTIIEALEKKITELGGQVATQIEIVSVKKVDDQ-FVLKSADQTFTCEKLIVT 161
Cdd:pfam03486  81 DFIAFFESLGVPLKEEDHGRLFPDSDKASDIVDALLNELKELGVKIRLRTRVLSVEKDDDGrFRVKTGGEELEADSLVLA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231  162 TGGKSYPSTGSTGFGHEIARHFKHTITDLEAAESPLLTDFP---HKALQGISLDDVTLSYGKHVITH--DLLFTHFGLSG 236
Cdd:pfam03486 161 TGGLSWPKTGSTGFGYPLAEQFGHTIIPLRPALVPFTIDEPflfLKRLSGISLKNVVLSNGKGGITFrgELLFTHRGLSG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231  237 PAALRMSSFV------KGGEVLSLDVLPQLSEKDLVTFLEENRE----KSLKNALKTLLPERLAEFFVQ----GYPEKVK 302
Cdd:pfam03486 241 PAILQLSSYWrrailkKGGVTLSIDLLPDLDAEELAARLEKPRGahpkKSLKNSLAGLLPKRLAEFLLEqagiEPDKKLA 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231  303 QLTEKEREQLVQSIKELKIPVTGKMSLAKSFVTKGGVSLKEINPKTLESKLVPGLHFAGEVMDINAHTGGFNITSALCTG 382
Cdd:pfam03486 321 QLSKKELAALAQLLKAWTFTPNGTEGYRTAEVTAGGVDTKELSSKTMESKKVPGLFFAGEVLDVDGWTGGYNLQWAWSSG 400


                  ....*
gi 444285231  383 WVAGS 387
Cdd:pfam03486 401 YAAGQ 405
 
Name Accession Description Interval E-value
HI0933_like pfam03486
HI0933-like protein;
4-387 0e+00

HI0933-like protein;


Pssm-ID: 427330 [Multi-domain]  Cd Length: 406  Bit Score: 560.66  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231    4 FDTIVIGGGPAGMMATISSSFYGQKTLLIEKNRKLGKKLAGTGGGRCNVTN-NGSLDNLLAGIPGNGRFLYSVFSQFDNH 82
Cdd:pfam03486   1 FDVIVIGGGAAGLMAAISAAKRGRRVLLIEKGKKLGRKILISGGGRCNVTNlSEEPDNFLSRYPGNPKFLKSALSRFTPW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231   83 DIINFFTENGVKLKVEDHGRVFPASDKSRTIIEALEKKITELGGQVATQIEIVSVKKVDDQ-FVLKSADQTFTCEKLIVT 161
Cdd:pfam03486  81 DFIAFFESLGVPLKEEDHGRLFPDSDKASDIVDALLNELKELGVKIRLRTRVLSVEKDDDGrFRVKTGGEELEADSLVLA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231  162 TGGKSYPSTGSTGFGHEIARHFKHTITDLEAAESPLLTDFP---HKALQGISLDDVTLSYGKHVITH--DLLFTHFGLSG 236
Cdd:pfam03486 161 TGGLSWPKTGSTGFGYPLAEQFGHTIIPLRPALVPFTIDEPflfLKRLSGISLKNVVLSNGKGGITFrgELLFTHRGLSG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231  237 PAALRMSSFV------KGGEVLSLDVLPQLSEKDLVTFLEENRE----KSLKNALKTLLPERLAEFFVQ----GYPEKVK 302
Cdd:pfam03486 241 PAILQLSSYWrrailkKGGVTLSIDLLPDLDAEELAARLEKPRGahpkKSLKNSLAGLLPKRLAEFLLEqagiEPDKKLA 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231  303 QLTEKEREQLVQSIKELKIPVTGKMSLAKSFVTKGGVSLKEINPKTLESKLVPGLHFAGEVMDINAHTGGFNITSALCTG 382
Cdd:pfam03486 321 QLSKKELAALAQLLKAWTFTPNGTEGYRTAEVTAGGVDTKELSSKTMESKKVPGLFFAGEVLDVDGWTGGYNLQWAWSSG 400


                  ....*
gi 444285231  383 WVAGS 387
Cdd:pfam03486 401 YAAGQ 405
TIGR00275 TIGR00275
flavoprotein, HI0933 family; The model when searched with a partial length search brings in ...
 7-387 1.85e-180

flavoprotein, HI0933 family; The model when searched with a partial length search brings in proteins with a dinucleotide-binding motif (Rossman fold) over the initial 40 residues of the model, including oxidoreductases and dehydrogenases. Partially characterized members include an FAD-binding protein from Bacillus cereus and flavoprotein HI0933 from Haemophilus influenzae. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 272992 [Multi-domain]  Cd Length: 400  Bit Score: 507.13  E-value: 1.85e-180
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231    7 IVIGGGPAGMMATISSSFYGQKTLLIEKNRKLGKKLAGTGGGRCNVTNNGSLDNLLAGIPGNGRFLYSVFSQFDNHDIIN 86
Cdd:TIGR00275   1 IIIGGGAAGLMAAITAARAGLSVLLLEKNKKIGKKLLISGGGRCNLTNSCPTPEFVAYYPRNGKFLRSALSRFSNKDLID 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231   87 FFTENGVKLKVEDHGRVFPASDKSRTIIEALEKKITELGGQVATQIEIVSVKKVDDQFVLKSADQTFTCEKLIVTTGGKS 166
Cdd:TIGR00275  81 FFESLGLELKVEEDGRVFPCSDSAADVLDALLNELKELGVEILTNSKVKSIEKEDGGFGVETSGGEYEADKVIIATGGLS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231  167 YPSTGSTGFGHEIARHFKHTITDLEAAESPLLTDFP-HKALQGISLDDVTLSY--GKHVITH--DLLFTHFGLSGPAALR 241
Cdd:TIGR00275 161 YPQLGSTGDGYEIAESLGHTIVPPVPALVPLTLDESfLKELSGISLDGVVLSLvnGKKVLEEfgELLFTHFGLSGPAILD 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231  242 MSSFV------KGGEVLSLDVLPQLSEKDLVTFLEENRE----KSLKNALKTLLPERLAEFFVQGYP----EKVKQLTEK 307
Cdd:TIGR00275 241 LSAFAarallkHKGVELEIDLLPDLSEEELEQRLKRLRKsnpkKTVKNILKGLLPKRLAELLLEQLGidpdLPAAQLSKK 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231  308 EREQLVQSIKELKIPVTGKMSLAKSFVTKGGVSLKEINPKTLESKLVPGLHFAGEVMDINAHTGGFNITSALCTGWVAGS 387
Cdd:TIGR00275 321 EIKKLVQLLKNWPFTISGTRGFKEAEVTAGGVSLKEINPKTMESKLVPGLYFAGEVLDIDGDTGGYNLQWAWSSGYLAGK 400
YhiN COG2081
Predicted flavoprotein YhiN [General function prediction only];
7-386 2.86e-177

Predicted flavoprotein YhiN [General function prediction only];


Pssm-ID: 441684 [Multi-domain]  Cd Length: 402  Bit Score: 499.19  E-value: 2.86e-177
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231   7 IVIGGGPAGMMATISSSFYGQKTLLIEKNRKLGKKLAGTGGGRCNVTNNGSLDNLLAGIPGNGRFLYSVFSQFDNHDIIN 86
Cdd:COG2081    1 IVIGAGAAGLMAAITAAERGARVLLLEKNPKVGRKILISGGGRCNFTNSEPLPEFLNYYGGNPHFLKSALSRFTPEDLIA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231  87 FFTENGVKLKVEDHGRVFPASDKSRTIIEALEKKITELGGQVATQIEIVSVKKVDDQFVLKSAD-QTFTCEKLIVTTGGK 165
Cdd:COG2081   81 FFEGLGIETKEESSGRVFPDSSKASDILRALLAELREAGVEIRLRTRVTGIEKEDGGFGVETPDgETVRADAVVLATGGL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231 166 SYPSTGSTGFGHEIARHFKHTITDLEAAESPL-LTDFPHKALQGISLDDVTLSYGKHVITH---DLLFTHFGLSGPAALR 241
Cdd:COG2081  161 SYPKLGSTGDGYRLAEQFGHTITPLRPALVPLtLSEHFFKRLAGLSLKNVALSVGGKKIASfrgELLFTHRGLSGPAILQ 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231 242 MSSFV-----KGGEVLSLDVLPQLSEKDLVTFLEENRE----KSLKNALKTLLPERLAEFFVQGYPE--KVKQLTEKERE 310
Cdd:COG2081  241 LSSYWrdalkKGGATLTIDLLPDLDLEELDARLARPREkngkKSLKNVLRGLLPKRLAALLLELADPdkPLAQLSKKERE 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 444285231 311 QLVQSIKELKIPVTGKMSLAKSFVTKGGVSLKEINPKTLESKLVPGLHFAGEVMDINAHTGGFNITSALCTGWVAG 386
Cdd:COG2081  321 ALAALLKAWPLTPTGTRGYDEAIVTAGGVDTKELDPKTMESKKVPGLYFAGEVLDVDGPTGGYNLQWAWSSGYAAG 396
PRK06327 PRK06327
dihydrolipoamide dehydrogenase; Validated
 1-45 6.39e-06

dihydrolipoamide dehydrogenase; Validated


Pssm-ID: 235779 [Multi-domain]  Cd Length: 475  Bit Score: 48.00  E-value: 6.39e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 444285231   1 MKHFDTIVIGGGPAGMMATISSSFYGQKTLLIE--KNRKLGKKLAGT 45
Cdd:PRK06327   2 SKQFDVVVIGAGPGGYVAAIRAAQLGLKVACIEawKNPKGKPALGGT 48
 
Name Accession Description Interval E-value
HI0933_like pfam03486
HI0933-like protein;
4-387 0e+00

HI0933-like protein;


Pssm-ID: 427330 [Multi-domain]  Cd Length: 406  Bit Score: 560.66  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231    4 FDTIVIGGGPAGMMATISSSFYGQKTLLIEKNRKLGKKLAGTGGGRCNVTN-NGSLDNLLAGIPGNGRFLYSVFSQFDNH 82
Cdd:pfam03486   1 FDVIVIGGGAAGLMAAISAAKRGRRVLLIEKGKKLGRKILISGGGRCNVTNlSEEPDNFLSRYPGNPKFLKSALSRFTPW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231   83 DIINFFTENGVKLKVEDHGRVFPASDKSRTIIEALEKKITELGGQVATQIEIVSVKKVDDQ-FVLKSADQTFTCEKLIVT 161
Cdd:pfam03486  81 DFIAFFESLGVPLKEEDHGRLFPDSDKASDIVDALLNELKELGVKIRLRTRVLSVEKDDDGrFRVKTGGEELEADSLVLA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231  162 TGGKSYPSTGSTGFGHEIARHFKHTITDLEAAESPLLTDFP---HKALQGISLDDVTLSYGKHVITH--DLLFTHFGLSG 236
Cdd:pfam03486 161 TGGLSWPKTGSTGFGYPLAEQFGHTIIPLRPALVPFTIDEPflfLKRLSGISLKNVVLSNGKGGITFrgELLFTHRGLSG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231  237 PAALRMSSFV------KGGEVLSLDVLPQLSEKDLVTFLEENRE----KSLKNALKTLLPERLAEFFVQ----GYPEKVK 302
Cdd:pfam03486 241 PAILQLSSYWrrailkKGGVTLSIDLLPDLDAEELAARLEKPRGahpkKSLKNSLAGLLPKRLAEFLLEqagiEPDKKLA 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231  303 QLTEKEREQLVQSIKELKIPVTGKMSLAKSFVTKGGVSLKEINPKTLESKLVPGLHFAGEVMDINAHTGGFNITSALCTG 382
Cdd:pfam03486 321 QLSKKELAALAQLLKAWTFTPNGTEGYRTAEVTAGGVDTKELSSKTMESKKVPGLFFAGEVLDVDGWTGGYNLQWAWSSG 400


                  ....*
gi 444285231  383 WVAGS 387
Cdd:pfam03486 401 YAAGQ 405
TIGR00275 TIGR00275
flavoprotein, HI0933 family; The model when searched with a partial length search brings in ...
 7-387 1.85e-180

flavoprotein, HI0933 family; The model when searched with a partial length search brings in proteins with a dinucleotide-binding motif (Rossman fold) over the initial 40 residues of the model, including oxidoreductases and dehydrogenases. Partially characterized members include an FAD-binding protein from Bacillus cereus and flavoprotein HI0933 from Haemophilus influenzae. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 272992 [Multi-domain]  Cd Length: 400  Bit Score: 507.13  E-value: 1.85e-180
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231    7 IVIGGGPAGMMATISSSFYGQKTLLIEKNRKLGKKLAGTGGGRCNVTNNGSLDNLLAGIPGNGRFLYSVFSQFDNHDIIN 86
Cdd:TIGR00275   1 IIIGGGAAGLMAAITAARAGLSVLLLEKNKKIGKKLLISGGGRCNLTNSCPTPEFVAYYPRNGKFLRSALSRFSNKDLID 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231   87 FFTENGVKLKVEDHGRVFPASDKSRTIIEALEKKITELGGQVATQIEIVSVKKVDDQFVLKSADQTFTCEKLIVTTGGKS 166
Cdd:TIGR00275  81 FFESLGLELKVEEDGRVFPCSDSAADVLDALLNELKELGVEILTNSKVKSIEKEDGGFGVETSGGEYEADKVIIATGGLS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231  167 YPSTGSTGFGHEIARHFKHTITDLEAAESPLLTDFP-HKALQGISLDDVTLSY--GKHVITH--DLLFTHFGLSGPAALR 241
Cdd:TIGR00275 161 YPQLGSTGDGYEIAESLGHTIVPPVPALVPLTLDESfLKELSGISLDGVVLSLvnGKKVLEEfgELLFTHFGLSGPAILD 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231  242 MSSFV------KGGEVLSLDVLPQLSEKDLVTFLEENRE----KSLKNALKTLLPERLAEFFVQGYP----EKVKQLTEK 307
Cdd:TIGR00275 241 LSAFAarallkHKGVELEIDLLPDLSEEELEQRLKRLRKsnpkKTVKNILKGLLPKRLAELLLEQLGidpdLPAAQLSKK 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231  308 EREQLVQSIKELKIPVTGKMSLAKSFVTKGGVSLKEINPKTLESKLVPGLHFAGEVMDINAHTGGFNITSALCTGWVAGS 387
Cdd:TIGR00275 321 EIKKLVQLLKNWPFTISGTRGFKEAEVTAGGVSLKEINPKTMESKLVPGLYFAGEVLDIDGDTGGYNLQWAWSSGYLAGK 400
YhiN COG2081
Predicted flavoprotein YhiN [General function prediction only];
7-386 2.86e-177

Predicted flavoprotein YhiN [General function prediction only];


Pssm-ID: 441684 [Multi-domain]  Cd Length: 402  Bit Score: 499.19  E-value: 2.86e-177
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231   7 IVIGGGPAGMMATISSSFYGQKTLLIEKNRKLGKKLAGTGGGRCNVTNNGSLDNLLAGIPGNGRFLYSVFSQFDNHDIIN 86
Cdd:COG2081    1 IVIGAGAAGLMAAITAAERGARVLLLEKNPKVGRKILISGGGRCNFTNSEPLPEFLNYYGGNPHFLKSALSRFTPEDLIA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231  87 FFTENGVKLKVEDHGRVFPASDKSRTIIEALEKKITELGGQVATQIEIVSVKKVDDQFVLKSAD-QTFTCEKLIVTTGGK 165
Cdd:COG2081   81 FFEGLGIETKEESSGRVFPDSSKASDILRALLAELREAGVEIRLRTRVTGIEKEDGGFGVETPDgETVRADAVVLATGGL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231 166 SYPSTGSTGFGHEIARHFKHTITDLEAAESPL-LTDFPHKALQGISLDDVTLSYGKHVITH---DLLFTHFGLSGPAALR 241
Cdd:COG2081  161 SYPKLGSTGDGYRLAEQFGHTITPLRPALVPLtLSEHFFKRLAGLSLKNVALSVGGKKIASfrgELLFTHRGLSGPAILQ 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231 242 MSSFV-----KGGEVLSLDVLPQLSEKDLVTFLEENRE----KSLKNALKTLLPERLAEFFVQGYPE--KVKQLTEKERE 310
Cdd:COG2081  241 LSSYWrdalkKGGATLTIDLLPDLDLEELDARLARPREkngkKSLKNVLRGLLPKRLAALLLELADPdkPLAQLSKKERE 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 444285231 311 QLVQSIKELKIPVTGKMSLAKSFVTKGGVSLKEINPKTLESKLVPGLHFAGEVMDINAHTGGFNITSALCTGWVAG 386
Cdd:COG2081  321 ALAALLKAWPLTPTGTRGYDEAIVTAGGVDTKELDPKTMESKKVPGLYFAGEVLDVDGPTGGYNLQWAWSSGYAAG 396
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
4-163 1.20e-07

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 52.81  E-value: 1.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231   4 FDTIVIGGGPAGMMATISSSFYGQKTLLIEKnrklgkklaGTGGGRCNVTnngsldnllagipgngrflysvfsqfdnHD 83
Cdd:COG0492    1 YDVVIIGAGPAGLTAAIYAARAGLKTLVIEG---------GEPGGQLATT----------------------------KE 43

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231  84 IINFFtenGvklkvedhgrvFPASDKSRTIIEALEKKITELGGQVATQiEIVSVKKVDDQFVLKSAD-QTFTCEKLIVTT 162
Cdd:COG0492   44 IENYP---G-----------FPEGISGPELAERLREQAERFGAEILLE-EVTSVDKDDGPFRVTTDDgTEYEAKAVIIAT 108


                 .
gi 444285231 163 G 163
Cdd:COG0492  109 G 109
SdhA COG1053
Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and ...
 1-180 8.81e-07

Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440673 [Multi-domain]  Cd Length: 443  Bit Score: 50.60  E-value: 8.81e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231   1 MKHFDTIVIGGGPAGMMATISSSFYGQKTLLIEKNRKLGkklaGT----GGGrCNVTNNG--------SLDN----LLAG 64
Cdd:COG1053    1 DHEYDVVVVGSGGAGLRAALEAAEAGLKVLVLEKVPPRG----GHtaaaQGG-INAAGTNvqkaagedSPEEhfydTVKG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231  65 IPGNG------RFLysvfsqfDN-HDIINFFTENGVKLKVEDHGRV--FPASDKSRT----------IIEALEKKITELG 125
Cdd:COG1053   76 GDGLAdqdlveALA-------EEaPEAIDWLEAQGVPFSRTPDGRLpqFGGHSVGRTcyagdgtghaLLATLYQAALRLG 148

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 444285231 126 GQVATQIEIVSVKKVDDQF---VLKSAD---QTFTCEKLIVTTGG------------------KSYPSTGSTGFGHEIA 180
Cdd:COG1053  149 VEIFTETEVLDLIVDDGRVvgvVARDRTgeiVRIRAKAVVLATGGfgrnyemraeylpeaegaLSTNAPGNTGDGIAMA 227
Lpd COG1249
Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex ...
 1-39 4.99e-06

Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase [Energy production and conversion]; Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase is part of the Pathway/BioSystem: Glycine cleavagePyruvate oxidation


Pssm-ID: 440861 [Multi-domain]  Cd Length: 456  Bit Score: 48.16  E-value: 4.99e-06
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 444285231   1 MKHFDTIVIGGGPAGMMATISSSFYGQKTLLIEKnRKLG 39
Cdd:COG1249    1 MKDYDLVVIGAGPGGYVAAIRAAQLGLKVALVEK-GRLG 38
FAD_oxidored pfam12831
FAD dependent oxidoreductase; This family of proteins contains FAD dependent oxidoreductases ...
 5-64 5.90e-06

FAD dependent oxidoreductase; This family of proteins contains FAD dependent oxidoreductases and related proteins.


Pssm-ID: 432816 [Multi-domain]  Cd Length: 420  Bit Score: 47.99  E-value: 5.90e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231    5 DTIVIGGGPAGMMATISSSFYGQKTLLIEKNRKLGKklAGTGGGRCNVTNNGSLDNLLAG 64
Cdd:pfam12831   1 DVVVVGGGPAGVAAAIAAARAGAKVLLVERRGFLGG--MLTSGLVGPDMGFYLNKEQVVG 58
PRK06327 PRK06327
dihydrolipoamide dehydrogenase; Validated
 1-45 6.39e-06

dihydrolipoamide dehydrogenase; Validated


Pssm-ID: 235779 [Multi-domain]  Cd Length: 475  Bit Score: 48.00  E-value: 6.39e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 444285231   1 MKHFDTIVIGGGPAGMMATISSSFYGQKTLLIE--KNRKLGKKLAGT 45
Cdd:PRK06327   2 SKQFDVVVIGAGPGGYVAAIRAAQLGLKVACIEawKNPKGKPALGGT 48
lipoamide_DH TIGR01350
dihydrolipoamide dehydrogenase; This model describes dihydrolipoamide dehydrogenase, a ...
 3-179 6.67e-06

dihydrolipoamide dehydrogenase; This model describes dihydrolipoamide dehydrogenase, a flavoprotein that acts in a number of ways. It is the E3 component of dehydrogenase complexes for pyruvate, 2-oxoglutarate, 2-oxoisovalerate, and acetoin. It can also serve as the L protein of the glycine cleavage system. This family includes a few members known to have distinct functions (ferric leghemoglobin reductase and NADH:ferredoxin oxidoreductase) but that may be predicted by homology to act as dihydrolipoamide dehydrogenase as well. The motif GGXCXXXGCXP near the N-terminus contains a redox-active disulfide.


Pssm-ID: 273568 [Multi-domain]  Cd Length: 460  Bit Score: 48.02  E-value: 6.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231    3 HFDTIVIGGGPAGMMATISSSFYGQKTLLIEKnrklgKKLAGTgggrCnvTNNGSldnllagIPG----NGRFLYSVFSQ 78
Cdd:TIGR01350   1 AYDVIVIGGGPGGYVAAIRAAQLGLKVALVEK-----EYLGGT----C--LNVGC-------IPTkallHSAEVYDEIKH 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231   79 FDNHDIinffTENGVKLKVED-HGRVFPASDKSRTIIEALEK--KITELGGQ-VATQIEIVSVKKvddqfvlKSADQTFT 154
Cdd:TIGR01350  63 AKDLGI----EVENVSVDWEKmQKRKNKVVKKLVGGVSGLLKknKVTVIKGEaKFLDPGTVSVTG-------ENGEETLE 131

                         170       180
                  ....*....|....*....|....*
gi 444285231  155 CEKLIVTTGGKSYPSTGSTGFGHEI 179
Cdd:TIGR01350 132 AKNIIIATGSRPRSLPGPFDFDGKV 156
PRK05249 PRK05249
Si-specific NAD(P)(+) transhydrogenase;
1-39 3.28e-05

Si-specific NAD(P)(+) transhydrogenase;


Pssm-ID: 235373 [Multi-domain]  Cd Length: 461  Bit Score: 45.92  E-value: 3.28e-05
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 444285231   1 MKHFDTIVIGGGPAGMMATISSSFYGQKTLLIEKNRKLG 39
Cdd:PRK05249   3 MYDYDLVVIGSGPAGEGAAMQAAKLGKRVAVIERYRNVG 41
PRK06416 PRK06416
dihydrolipoamide dehydrogenase; Reviewed
 3-39 4.43e-05

dihydrolipoamide dehydrogenase; Reviewed


Pssm-ID: 235798 [Multi-domain]  Cd Length: 462  Bit Score: 45.14  E-value: 4.43e-05
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 444285231   3 HFDTIVIGGGPAGMMATISSSFYGQKTLLIEKnRKLG 39
Cdd:PRK06416   4 EYDVIVIGAGPGGYVAAIRAAQLGLKVAIVEK-EKLG 39
PRK06292 PRK06292
dihydrolipoamide dehydrogenase; Validated
 1-50 4.76e-05

dihydrolipoamide dehydrogenase; Validated


Pssm-ID: 235774 [Multi-domain]  Cd Length: 460  Bit Score: 45.17  E-value: 4.76e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 444285231   1 MKHFDTIVIGGGPAGMMATISSSFYGQKTLLIEKnrklgkklaGTGGGRC 50
Cdd:PRK06292   1 MEKYDVIVIGAGPAGYVAARRAAKLGKKVALIEK---------GPLGGTC 41
FAD_binding_2 pfam00890
FAD binding domain; This family includes members that bind FAD. This family includes the ...
 5-103 1.45e-04

FAD binding domain; This family includes members that bind FAD. This family includes the flavoprotein subunits from succinate and fumarate dehydrogenase, aspartate oxidase and the alpha subunit of adenylylsulphate reductase.


Pssm-ID: 395718 [Multi-domain]  Cd Length: 398  Bit Score: 43.43  E-value: 1.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231    5 DTIVIGGGPAGMMATISSSFYGQKTLLIEKNRKLGKKLAGTGGGRC--NVTNNGSLDN-------LLAGIPGNGRFLYSV 75
Cdd:pfam00890   1 DVLVIGGGLAGLAAALAAAEAGLKVAVVEKGQPFGGATAWSSGGIDalGNPPQGGIDSpelhptdTLKGLDELADHPYVE 80

                          90       100
                  ....*....|....*....|....*...
gi 444285231   76 FSQFDNHDIINFFTENGVKLKVEDHGRV 103
Cdd:pfam00890  81 AFVEAAPEAVDWLEALGVPFSRTEDGHL 108
PRK07494 PRK07494
UbiH/UbiF family hydroxylase;
1-32 3.39e-04

UbiH/UbiF family hydroxylase;


Pssm-ID: 181001 [Multi-domain]  Cd Length: 388  Bit Score: 42.58  E-value: 3.39e-04
                         10        20        30
                 ....*....|....*....|....*....|..
gi 444285231   1 MKHFDTIVIGGGPAGMMATISSSFYGQKTLLI 32
Cdd:PRK07494   5 KEHTDIAVIGGGPAGLAAAIALARAGASVALV 36
FAD_binding_3 pfam01494
FAD binding domain; This domain is involved in FAD binding in a number of enzymes.
 5-166 7.54e-04

FAD binding domain; This domain is involved in FAD binding in a number of enzymes.


Pssm-ID: 396193 [Multi-domain]  Cd Length: 348  Bit Score: 41.16  E-value: 7.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231    5 DTIVIGGGPAGMMATISSSFYGQKTLLIEKNRKLgkklagTGGGRCNVTNNGSLDnLL--AGIpgngrfLYSVFSQFDNH 82
Cdd:pfam01494   3 DVLIVGGGPAGLMLALLLARAGVRVVLVERHATT------SVLPRAHGLNQRTME-LLrqAGL------EDRILAEGVPH 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231   83 DIINFFTENG-VKLKVEDHGR-----VFPASDKSRTIIEALEkkitELGGQVATQIEIVSVKKVDD------QFVLKSAD 150
Cdd:pfam01494  70 EGMGLAFYNTrRRADLDFLTSpprvtVYPQTELEPILVEHAE----ARGAQVRFGTEVLSLEQDGDgvtavvRDRRDGEE 145

                         170
                  ....*....|....*.
gi 444285231  151 QTFTCEKLIVTTGGKS 166
Cdd:pfam01494 146 YTVRAKYLVGCDGGRS 161
PRK12835 PRK12835
3-ketosteroid-delta-1-dehydrogenase; Reviewed
 3-48 9.79e-04

3-ketosteroid-delta-1-dehydrogenase; Reviewed


Pssm-ID: 237221 [Multi-domain]  Cd Length: 584  Bit Score: 41.33  E-value: 9.79e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 444285231   3 HFDTIVIGGGPAGMMATISSSFYGQKTLLIEKNRKLGKKLAGTGGG 48
Cdd:PRK12835  11 EVDVLVVGSGGGGMTAALTAAARGLDTLVVEKSAHFGGSTALSGGG 56
PRK07843 PRK07843
3-oxosteroid 1-dehydrogenase;
4-48 1.14e-03

3-oxosteroid 1-dehydrogenase;


Pssm-ID: 236111 [Multi-domain]  Cd Length: 557  Bit Score: 40.79  E-value: 1.14e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 444285231   4 FDTIVIGGGPAGMMATISSSFYGQKTLLIEKNRKLGKKLAGTGGG 48
Cdd:PRK07843   8 YDVVVVGSGAAGMVAALTAAHRGLSTVVVEKAPHYGGSTARSGGG 52
PRK06134 PRK06134
putative FAD-binding dehydrogenase; Reviewed
 5-47 1.37e-03

putative FAD-binding dehydrogenase; Reviewed


Pssm-ID: 180419 [Multi-domain]  Cd Length: 581  Bit Score: 40.86  E-value: 1.37e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 444285231   5 DTIVIGGGPAGMMATISSSFYGQKTLLIEKNRKLGKKLAGTGG 47
Cdd:PRK06134  14 DVLVIGSGAAGLSAAVTAAWHGLKVIVVEKDPVFGGTTAWSGG 56
GlpB COG3075
Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism];
1-32 1.86e-03

Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism];


Pssm-ID: 442309  Cd Length: 415  Bit Score: 40.16  E-value: 1.86e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 444285231   1 MKhFDTIVIGGGPAGMMATISSSFYGQKTLLI 32
Cdd:COG3075    1 MK-FDVVVIGGGLAGLTAAIRAAEAGLRVAIV 31
PRK06370 PRK06370
FAD-containing oxidoreductase;
1-36 2.40e-03

FAD-containing oxidoreductase;


Pssm-ID: 235787 [Multi-domain]  Cd Length: 463  Bit Score: 39.80  E-value: 2.40e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 444285231   1 MKHFDTIVIGGGPAGMMATISSSFYGQKTLLIEKNR 36
Cdd:PRK06370   3 AQRYDAIVIGAGQAGPPLAARAAGLGMKVALIERGL 38
PRK12844 PRK12844
3-ketosteroid-delta-1-dehydrogenase; Reviewed
 4-48 2.56e-03

3-ketosteroid-delta-1-dehydrogenase; Reviewed


Pssm-ID: 183787 [Multi-domain]  Cd Length: 557  Bit Score: 39.74  E-value: 2.56e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 444285231   4 FDTIVIGGGPAGMMATISSSFYGQKTLLIEKNRKLGKKLAGTGGG 48
Cdd:PRK12844   7 YDVVVVGSGGGGMCAALAAADSGLEPLIVEKQDKVGGSTAMSGGV 51
COG1233 COG1233
Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and ...
 1-39 2.63e-03

Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440846 [Multi-domain]  Cd Length: 491  Bit Score: 39.83  E-value: 2.63e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 444285231   1 MKHFDTIVIGGGPAGMMATISSSFYGQKTLLIEKNRKLG 39
Cdd:COG1233    1 MMMYDVVVIGAGIGGLAAAALLARAGYRVTVLEKNDTPG 39
GIDA pfam01134
Glucose inhibited division protein A;
304-386 2.95e-03

Glucose inhibited division protein A;


Pssm-ID: 250388 [Multi-domain]  Cd Length: 391  Bit Score: 39.46  E-value: 2.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231  304 LTEKEREQLVQSIKelkipvtGkmsLAKSFVTKGGVSLKE--INP----KTLESKLVPGLHFAGevmDINAHTGgfnITS 377
Cdd:pfam01134 308 LPEDVQKRVLRTIP-------G---LENAEIVRPGYAIEYdyIDPpqllPTLETKKIPGLFFAG---QINGTEG---YEE 371


                  ....*....
gi 444285231  378 ALCTGWVAG 386
Cdd:pfam01134 372 AAAQGLLAG 380
PTZ00306 PTZ00306
NADH-dependent fumarate reductase; Provisional
 7-137 3.13e-03

NADH-dependent fumarate reductase; Provisional


Pssm-ID: 140327 [Multi-domain]  Cd Length: 1167  Bit Score: 39.76  E-value: 3.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231    7 IVIGGGPAGMMATISSSFYGQKTLLIEKNRKLG----KKLAGTGG------GRCNVTNNGSL---DNLLAGIPGNG---- 69
Cdd:PTZ00306  413 IVVGGGLAGCSAAIEAASCGAQVILLEKEAKLGgnsaKATSGINGwgtraqAKQDVLDGGKFferDTHLSGKGGHCdpgl 492

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444285231   70 -RFLySVFSQfdnhDIINFFTENGVKLKV------EDHGRVFPASDKSR--------TIIEALEKKI-TELGGQVaTQIE 133
Cdd:PTZ00306  493 vKTL-SVKSA----DAISWLSSLGVPLTVlsqlggASRKRCHRAPDKKDgtpvpigfTIMRTLEDHIrTKLSGRV-TIMT 566


                  ....
gi 444285231  134 IVSV 137
Cdd:PTZ00306  567 ETTV 570
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
8-43 3.23e-03

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 39.46  E-value: 3.23e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 444285231   8 VIGGGPAGMMATISSSFYGQKTLLIEKNRKLGKKLA 43
Cdd:COG1148  145 VIGGGIAGMTAALELAEQGYEVYLVEKEPELGGRAA 180
PRK12843 PRK12843
FAD-dependent oxidoreductase;
4-48 3.72e-03

FAD-dependent oxidoreductase;


Pssm-ID: 237225 [Multi-domain]  Cd Length: 578  Bit Score: 39.33  E-value: 3.72e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 444285231   4 FDTIVIGGGPAGMMATISSSFYGQKTLLIEKNRKLGKKLAGTGGG 48
Cdd:PRK12843  17 FDVIVIGAGAAGMSAALFAAIAGLKVLLVERTEYVGGTTATSAGT 61
PRK12839 PRK12839
FAD-dependent oxidoreductase;
4-47 4.43e-03

FAD-dependent oxidoreductase;


Pssm-ID: 237223 [Multi-domain]  Cd Length: 572  Bit Score: 39.04  E-value: 4.43e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 444285231   4 FDTIVIGGGPAGMMATISSSFYGQKTLLIEKNRKLGKKLAGTGG 47
Cdd:PRK12839   9 YDVVVVGSGAGGLSAAVAAAYGGAKVLVVEKASTCGGATAWSGG 52
PRK06116 PRK06116
glutathione reductase; Validated
 1-45 5.38e-03

glutathione reductase; Validated


Pssm-ID: 235701 [Multi-domain]  Cd Length: 450  Bit Score: 38.60  E-value: 5.38e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 444285231   1 MKHFDTIVIGGGPAGMMATISSSFYGQKTLLIEknrklGKKLAGT 45
Cdd:PRK06116   2 TKDYDLIVIGGGSGGIASANRAAMYGAKVALIE-----AKRLGGT 41
PRK05329 PRK05329
glycerol-3-phosphate dehydrogenase subunit GlpB;
2-35 8.23e-03

glycerol-3-phosphate dehydrogenase subunit GlpB;


Pssm-ID: 235412  Cd Length: 422  Bit Score: 37.91  E-value: 8.23e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 444285231   2 KHFDTIVIGGGPAGMMATISSSFYGQKTLLIEKN 35
Cdd:PRK05329   1 MKFDVLVIGGGLAGLTAALAAAEAGKRVALVAKG 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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