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Conserved domains on  [gi|451994471|gb|EMD86941|]
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hypothetical protein COCHEDRAFT_1217944 [Bipolaris maydis C5]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
13-100 6.29e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 53.86  E-value: 6.29e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451994471  13 LGRNYYKLKQYDKALEIFTKGIEtcQKPTL-NLYDYRAATYDKLERFSDAVKDGREMIRIQKSDVKGYLRTASVLEKMGK 91
Cdd:COG0457   14 LGLAYRRLGRYEEAIEDYEKALE--LDPDDaEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGR 91


                 ....*....
gi 451994471  92 EETALGIYK 100
Cdd:COG0457   92 YEEALEDYD 100
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 373-550 5.14e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd00116:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 319  Bit Score: 51.59  E-value: 5.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451994471 373 LALPDTLQHLVL-DNYWGLLPGITNTSPWARAKLADLTHLSLSGISVSPEKLemlldsyiedGALKSLPNSKPLQHLSL- 450
Cdd:cd00116   47 LRPQPSLKELCLsLNETGRIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGC----------GVLESLLRSSSLQELKLn 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451994471 451 RCLLDtdvtffIGPNAVLCRSPRVLTPALESLDLGTTPCTDDDVECL---LTYETGLKTIDLSNTNITGASIKMLADKLP 527
Cdd:cd00116  117 NNGLG------DRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALakaLRANRDLKELNLANNGIGDAGIRALAEGLK 190

                        170       180
                 ....*....|....*....|....*.
gi 451994471 528 S---LQSIVADNCmGITSRDAIQYAE 550
Cdd:cd00116  191 AncnLEVLDLNNN-GLTDEGASALAE 215
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 136-181 2.42e-06

F-box-like; This is an F-box-like family.


:

Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 44.40  E-value: 2.42e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 451994471  136 FSILPVELAEMVLEYLPFRHIVSCMRVSKGWRDyLSKLPKLWLHLD 181
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRE-LASDDSLWRRLC 45
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
13-100 6.29e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 53.86  E-value: 6.29e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451994471  13 LGRNYYKLKQYDKALEIFTKGIEtcQKPTL-NLYDYRAATYDKLERFSDAVKDGREMIRIQKSDVKGYLRTASVLEKMGK 91
Cdd:COG0457   14 LGLAYRRLGRYEEAIEDYEKALE--LDPDDaEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGR 91


                 ....*....
gi 451994471  92 EETALGIYK 100
Cdd:COG0457   92 YEEALEDYD 100
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 373-550 5.14e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 51.59  E-value: 5.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451994471 373 LALPDTLQHLVL-DNYWGLLPGITNTSPWARAKLADLTHLSLSGISVSPEKLemlldsyiedGALKSLPNSKPLQHLSL- 450
Cdd:cd00116   47 LRPQPSLKELCLsLNETGRIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGC----------GVLESLLRSSSLQELKLn 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451994471 451 RCLLDtdvtffIGPNAVLCRSPRVLTPALESLDLGTTPCTDDDVECL---LTYETGLKTIDLSNTNITGASIKMLADKLP 527
Cdd:cd00116  117 NNGLG------DRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALakaLRANRDLKELNLANNGIGDAGIRALAEGLK 190

                        170       180
                 ....*....|....*....|....*.
gi 451994471 528 S---LQSIVADNCmGITSRDAIQYAE 550
Cdd:cd00116  191 AncnLEVLDLNNN-GLTDEGASALAE 215
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 136-181 2.42e-06

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 44.40  E-value: 2.42e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 451994471  136 FSILPVELAEMVLEYLPFRHIVSCMRVSKGWRDyLSKLPKLWLHLD 181
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRE-LASDDSLWRRLC 45
FBOX smart00256
A Receptor for Ubiquitination Targets;
139-179 2.59e-06

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 44.35  E-value: 2.59e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 451994471   139 LPVELAEMVLEYLPFRHIVSCMRVSKGWRDYLSKLPKLWLH 179
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 3-96 3.47e-06

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 49.98  E-value: 3.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451994471    3 RQMSAEEFQELGRNYYKLKQYDKALEIFTKGIETcqKPTLNLYDYRAATYDKLERFSDAVKDGREMIRIQKSDVKGYLRT 82
Cdd:TIGR00990 123 RKKYAAKLKEKGNKAYRNKDFNKAIKLYSKAIEC--KPDPVYYSNRAACHNALGDWEKVVEDTTAALELDPDYSKALNRR 200

                          90
                  ....*....|....
gi 451994471   83 ASVLEKMGKEETAL 96
Cdd:TIGR00990 201 ANAYDGLGKYADAL 214
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 137-171 5.16e-05

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 40.51  E-value: 5.16e-05
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 451994471 137 SILPVELAEMVLEYLPFRHIVSCMRVSKGWRDYLS 171
Cdd:cd09917    1 SDLPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 7-95 5.22e-05

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 45.55  E-value: 5.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451994471   7 AEEFQELGRNYYKLKQYDKALEIFTKGIETcQKPTLNLYDYRAATYDKLERFSDAVKDGREMIRIQKSDVKGYLRTASVL 86
Cdd:PLN03088   2 AKDLEDKAKEAFVDDDFALAVDLYTQAIDL-DPNNAELYADRAQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGTAC 80


                 ....*....
gi 451994471  87 EKMGKEETA 95
Cdd:PLN03088  81 MKLEEYQTA 89
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
350-536 6.11e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.61  E-value: 6.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451994471 350 PQDASQMPPITTLvmkRVSFELYLALPDTLQHLVLDNywgllPGITNTsPWARAKLADLTHLSLSG--ISVSPE------ 421
Cdd:COG4886   89 LTDLGDLTNLTEL---DLSGNEELSNLTNLESLDLSG-----NQLTDL-PEELANLTNLKELDLSNnqLTDLPEplgnlt 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451994471 422 KLEMLldsYIEDGALKSLPNS----KPLQHLSLRcllDTDVTFFigpnavlcrsPRVLT--PALESLDLGTTPCTDddVE 495
Cdd:COG4886  160 NLKSL---DLSNNQLTDLPEElgnlTNLKELDLS---NNQITDL----------PEPLGnlTNLEELDLSGNQLTD--LP 221

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 451994471 496 CLLTYETGLKTIDLSNTNITgaSIKMLAdKLPSLQSIVADN 536
Cdd:COG4886  222 EPLANLTNLETLDLSNNQLT--DLPELG-NLTNLEELDLSN 259
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 7-35 2.71e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 35.50  E-value: 2.71e-03
                           10        20
                   ....*....|....*....|....*....
gi 451994471     7 AEEFQELGRNYYKLKQYDKALEIFTKGIE 35
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALE 29
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 7-35 2.92e-03

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 35.58  E-value: 2.92e-03
                          10        20
                  ....*....|....*....|....*....
gi 451994471    7 AEEFQELGRNYYKLKQYDKALEIFTKGIE 35
Cdd:pfam07719   1 AEALYNLGLAYYKLGDYEEALEAYEKALE 29
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
13-100 6.29e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 53.86  E-value: 6.29e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451994471  13 LGRNYYKLKQYDKALEIFTKGIEtcQKPTL-NLYDYRAATYDKLERFSDAVKDGREMIRIQKSDVKGYLRTASVLEKMGK 91
Cdd:COG0457   14 LGLAYRRLGRYEEAIEDYEKALE--LDPDDaEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGR 91


                 ....*....
gi 451994471  92 EETALGIYK 100
Cdd:COG0457   92 YEEALEDYD 100
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
7-100 1.30e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 53.09  E-value: 1.30e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451994471   7 AEEFQELGRNYYKLKQYDKALEIFTKGIETcqKPTL-NLYDYRAATYDKLERFSDAVKDGREMIRIQKSDVKGYLRTASV 85
Cdd:COG0457   42 AEALYNLGLAYLRLGRYEEALADYEQALEL--DPDDaEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLA 119

                         90
                 ....*....|....*
gi 451994471  86 LEKMGKEETALGIYK 100
Cdd:COG0457  120 LLELGRYDEAIEAYE 134
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 10-100 3.70e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 49.42  E-value: 3.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451994471  10 FQELGRNYYKLKQYDKALEIFTKGIEtcQKPT-LNLYDYRAATYDKLERFSDAVKDGREMIRIQKSDVKGYLRTASVLEK 88
Cdd:COG4783   41 FALLGEILLQLGDLDEAIVLLHEALE--LDPDePEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRA 118

                         90
                 ....*....|..
gi 451994471  89 MGKEETALGIYK 100
Cdd:COG4783  119 LGRPDEAIAALE 130
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 373-550 5.14e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 51.59  E-value: 5.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451994471 373 LALPDTLQHLVL-DNYWGLLPGITNTSPWARAKLADLTHLSLSGISVSPEKLemlldsyiedGALKSLPNSKPLQHLSL- 450
Cdd:cd00116   47 LRPQPSLKELCLsLNETGRIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGC----------GVLESLLRSSSLQELKLn 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451994471 451 RCLLDtdvtffIGPNAVLCRSPRVLTPALESLDLGTTPCTDDDVECL---LTYETGLKTIDLSNTNITGASIKMLADKLP 527
Cdd:cd00116  117 NNGLG------DRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALakaLRANRDLKELNLANNGIGDAGIRALAEGLK 190

                        170       180
                 ....*....|....*....|....*.
gi 451994471 528 S---LQSIVADNCmGITSRDAIQYAE 550
Cdd:cd00116  191 AncnLEVLDLNNN-GLTDEGASALAE 215
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 136-181 2.42e-06

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 44.40  E-value: 2.42e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 451994471  136 FSILPVELAEMVLEYLPFRHIVSCMRVSKGWRDyLSKLPKLWLHLD 181
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRE-LASDDSLWRRLC 45
FBOX smart00256
A Receptor for Ubiquitination Targets;
139-179 2.59e-06

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 44.35  E-value: 2.59e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 451994471   139 LPVELAEMVLEYLPFRHIVSCMRVSKGWRDYLSKLPKLWLH 179
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 7-104 3.01e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 47.11  E-value: 3.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451994471   7 AEEFQELGRNYYKLKQYDKALEIFTKGIEtcQKPT-LNLYDYRAATYDKLERFSDAVKDGREMIRIQKSDVKGYLRTASV 85
Cdd:COG4783    4 AEALYALAQALLLAGDYDEAEALLEKALE--LDPDnPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLA 81

                         90
                 ....*....|....*....
gi 451994471  86 LEKMGKEETALGIYKYGMK 104
Cdd:COG4783   82 LLKAGDYDEALALLEKALK 100
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 136-179 3.45e-06

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 44.07  E-value: 3.45e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 451994471  136 FSILPVELAEMVLEYLPFRHIVSCMRVSKGWRDyLSKLPKLWLH 179
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRS-LVDSLKLWKK 43
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 3-96 3.47e-06

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 49.98  E-value: 3.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451994471    3 RQMSAEEFQELGRNYYKLKQYDKALEIFTKGIETcqKPTLNLYDYRAATYDKLERFSDAVKDGREMIRIQKSDVKGYLRT 82
Cdd:TIGR00990 123 RKKYAAKLKEKGNKAYRNKDFNKAIKLYSKAIEC--KPDPVYYSNRAACHNALGDWEKVVEDTTAALELDPDYSKALNRR 200

                          90
                  ....*....|....
gi 451994471   83 ASVLEKMGKEETAL 96
Cdd:TIGR00990 201 ANAYDGLGKYADAL 214
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 11-100 5.55e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 48.19  E-value: 5.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451994471  11 QELGRNYYKLKQYDKALEIFTKGIETCQKpTLNLYDYRAATYDKLERFSDAVKDGREMIRIQKSDVKGYLRTASVLEKMG 90
Cdd:COG2956   80 LELAQDYLKAGLLDRAEELLEKLLELDPD-DAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQG 158

                         90
                 ....*....|
gi 451994471  91 KEETALGIYK 100
Cdd:COG2956  159 DYDEAIEALE 168
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 2-105 6.73e-06

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 46.49  E-value: 6.73e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451994471   2 ARQMSAEEFQELGRNYYKLKQYDKALEIFTKGIEtCQKPTLNLYDYRAATYDKLERFSDAVKDGREMIRIQKSDVKGYLR 81
Cdd:COG5010   49 KLAKAFAIESPSDNLYNKLGDFEESLALLEQALQ-LDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSN 127

                         90       100
                 ....*....|....*....|....
gi 451994471  82 TASVLEKMGKEETALGIYKYGMKN 105
Cdd:COG5010  128 LAALLLSLGQDDEAKAALQRALGT 151
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 6-123 3.25e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 43.84  E-value: 3.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451994471   6 SAEEFQELGRNYYKLKQYDKALEIFTKGIEtcQKP-TLNLYDYRAATYDKLERFSDAVKDGREMIRIQKSDVKGYLRTAS 84
Cdd:COG4235   16 DAEGWLLLGRAYLRLGRYDEALAAYEKALR--LDPdNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGL 93

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 451994471  85 VLEKMGKEETALGIYKyGMKNVGSKDKNFKLLQQLHDKL 123
Cdd:COG4235   94 AAFQQGDYAEAIAAWQ-KLLALLPADAPARLLEASIAEA 131
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 137-171 5.16e-05

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 40.51  E-value: 5.16e-05
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 451994471 137 SILPVELAEMVLEYLPFRHIVSCMRVSKGWRDYLS 171
Cdd:cd09917    1 SDLPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 7-95 5.22e-05

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 45.55  E-value: 5.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451994471   7 AEEFQELGRNYYKLKQYDKALEIFTKGIETcQKPTLNLYDYRAATYDKLERFSDAVKDGREMIRIQKSDVKGYLRTASVL 86
Cdd:PLN03088   2 AKDLEDKAKEAFVDDDFALAVDLYTQAIDL-DPNNAELYADRAQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGTAC 80


                 ....*....
gi 451994471  87 EKMGKEETA 95
Cdd:PLN03088  81 MKLEEYQTA 89
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 15-100 6.19e-05

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 42.67  E-value: 6.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451994471  15 RNYYKLKQYDKALEIFTKGIETCQKPTL--NLYDYRAATYDKLERFSDAVKDGREMIRIQKSDVK---GYLRTASVLEKM 89
Cdd:COG1729    1 KALLKAGDYDEAIAAFKAFLKRYPNSPLapDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKapdALLKLGLSYLEL 80

                         90
                 ....*....|.
gi 451994471  90 GKEETALGIYK 100
Cdd:COG1729   81 GDYDKARATLE 91
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
7-96 1.43e-04

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 43.37  E-value: 1.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451994471   7 AEEFQELGRNYYKLKQYDKALEIFTKGIETCqkPTL-NLYDYRAATYDKLERFSDAVKDGREMIRIQKSDVKGYLRTASV 85
Cdd:COG4785   73 AQLYYERGVAYDSLGDYDLAIADFDQALELD--PDLaEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIA 150

                         90
                 ....*....|.
gi 451994471  86 LEKMGKEETAL 96
Cdd:COG4785  151 LYYLGRYELAI 161
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 12-122 3.24e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.79  E-value: 3.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451994471  12 ELGRNYYKLKQYDKALEIFTKGIET---CQKPTLNLydyrAATYDKLERFSDAVKDGREMIRIQKSDVKGYLRTASVLEK 88
Cdd:COG2956  149 ELAELYLEQGDYDEAIEALEKALKLdpdCARALLLL----AELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEK 224

                         90       100       110
                 ....*....|....*....|....*....|....
gi 451994471  89 MGKEETALGIYKYGMKNVGSKDKNFKLLQQLHDK 122
Cdd:COG2956  225 LGDPEEALELLRKALELDPSDDLLLALADLLERK 258
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
350-536 6.11e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.61  E-value: 6.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451994471 350 PQDASQMPPITTLvmkRVSFELYLALPDTLQHLVLDNywgllPGITNTsPWARAKLADLTHLSLSG--ISVSPE------ 421
Cdd:COG4886   89 LTDLGDLTNLTEL---DLSGNEELSNLTNLESLDLSG-----NQLTDL-PEELANLTNLKELDLSNnqLTDLPEplgnlt 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451994471 422 KLEMLldsYIEDGALKSLPNS----KPLQHLSLRcllDTDVTFFigpnavlcrsPRVLT--PALESLDLGTTPCTDddVE 495
Cdd:COG4886  160 NLKSL---DLSNNQLTDLPEElgnlTNLKELDLS---NNQITDL----------PEPLGnlTNLEELDLSGNQLTD--LP 221

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 451994471 496 CLLTYETGLKTIDLSNTNITgaSIKMLAdKLPSLQSIVADN 536
Cdd:COG4886  222 EPLANLTNLETLDLSNNQLT--DLPELG-NLTNLEELDLSN 259
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
17-100 1.69e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 37.84  E-value: 1.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451994471  17 YYKLKQYDKALEIFTKGIEtcQKP-TLNLYDYRAATYDKLERFSDAVKdGREMIRIQKSDVKGYLRTASVLEKMGKEETA 95
Cdd:COG3063    2 YLKLGDLEEAEEYYEKALE--LDPdNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEA 78


                 ....*
gi 451994471  96 LGIYK 100
Cdd:COG3063   79 LAYLE 83
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
6-80 2.33e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 39.90  E-value: 2.33e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 451994471   6 SAEEFQELGRNYYKLKQYDKALEIFTKGIETcqKPT-LNLYDYRAATYDKLERFSDAVKDGREMIRIQKSDVKGYL 80
Cdd:COG4785  106 LAEAYNNRGLAYLLLGDYDAALEDFDRALEL--DPDyAYAYLNRGIALYYLGRYELAIADLEKALELDPNDPERAL 179
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 421-533 2.52e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.03  E-value: 2.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451994471 421 EKLEMLLDSYIEDGA---LKSLPNSKPLQHLSLR--CLLDTDVTFfigpnavLCRSPRVLtPALESLDLGTTPCTDDDV- 494
Cdd:cd00116  168 KELNLANNGIGDAGIralAEGLKANCNLEVLDLNnnGLTDEGASA-------LAETLASL-KSLEVLNLGDNNLTDAGAa 239

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 451994471 495 ---ECLLTYETGLKTIDLSNTNITGASIKMLADKLPSLQSIV 533
Cdd:cd00116  240 alaSALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLL 281
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 7-35 2.71e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 35.50  E-value: 2.71e-03
                           10        20
                   ....*....|....*....|....*....
gi 451994471     7 AEEFQELGRNYYKLKQYDKALEIFTKGIE 35
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALE 29
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 7-35 2.92e-03

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 35.58  E-value: 2.92e-03
                          10        20
                  ....*....|....*....|....*....
gi 451994471    7 AEEFQELGRNYYKLKQYDKALEIFTKGIE 35
Cdd:pfam07719   1 AEALYNLGLAYYKLGDYEEALEAYEKALE 29
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
13-101 3.36e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 39.60  E-value: 3.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451994471  13 LGRNYYKLKQYDKALEIFTKGIEtcQKPTL-NLYDYRAATYDKLERFSDAVKDGREMIRIQKSDVKGYLRTASVLEKMGK 91
Cdd:COG0457  116 LGLALLELGRYDEAIEAYERALE--LDPDDaDALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAA 193

                         90
                 ....*....|
gi 451994471  92 EETALGIYKY 101
Cdd:COG0457  194 EVLLALLLAL 203
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 431-543 3.76e-03

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 39.23  E-value: 3.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451994471 431 IEDGALKSLPNSKP-LQHLSLR-CLLDTDvtffIGPNAVLCRSPRvltpaLESLDLG-TTPC---TDDDVECLLTYETGL 504
Cdd:cd09293   65 IDDEGLIALAQSCPnLQVLDLRaCENITD----SGIVALATNCPK-----LQTINLGrHRNGhliTDVSLSALGKNCTFL 135

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 451994471 505 KTIDLSNTNITGASIKMLADK-LPSLQSIVADNCMGITSR 543
Cdd:cd09293  136 QTVGFAGCDVTDKGVWELASGcSKSLERLSLNNCRNLTDQ 175
F-box_SpPof1-like cd22147
F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar ...
 135-167 5.00e-03

F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar proteins; SpPof1, also called F-box/WD repeat-containing protein pof1, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is required for the inactivation of zip1 via ubiquitination. This subfamily also includes Saccharomyces cerevisiae methionine-requiring protein 30 (ScMET30, also called E3 ubiquitin ligase complex SCF(Met30) subunit MET30), Aspergillus niger sulfur controller B (AnSCONB, also called sulfur metabolite repression control protein B) and Neurospora crassa sulfur controller 2 (NcSCON2, also called sulfur metabolite repression control protein 2). ScMET30 acts as a transcriptional inhibitor that negatively regulates the expression of sulfur amino acid biosynthesis genes. It controls cell cycle function (being required for the G1/S transition and M-phase but not the S-phase), sulfur metabolism, and methionine biosynthesis as part of the E3 ubiquitin ligase complex SCF(Met30). AnSCONB and NcSCON2 are components of the SCF (sconB/scon-2) E3 ubiquitin ligase complexes involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438918  Cd Length: 46  Bit Score: 35.37  E-value: 5.00e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 451994471 135 PFSILPVELAEMVLEYLPFRHIVSCMRVSKGWR 167
Cdd:cd22147    1 FLSALPVELSLKILSYLDAKSLCRAAQVSKKWR 33
TPR_12 pfam13424
Tetratricopeptide repeat;
13-74 5.05e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 36.21  E-value: 5.05e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 451994471   13 LGRNYYKLKQYDKALEIFTKGIETCQK-------PTLNLYDYRAATYDKLERFSDAVKDGREMIRIQKS 74
Cdd:pfam13424   9 LAAVLRRLGRYDEALELLEKALEIARRllgpdhpLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 12-119 6.70e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 38.56  E-value: 6.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451994471  12 ELGRNYYKLKQYDKALEIFTKGIETCQKpTLNLYDYRAATYDKLERFSDAVKDGREMIRIQKSDVKGYLRTASVLEKMGK 91
Cdd:COG2956   13 FKGLNYLLNGQPDKAIDLLEEALELDPE-TVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGL 91

                         90       100
                 ....*....|....*....|....*...
gi 451994471  92 EETALGIYKygmKNVGSKDKNFKLLQQL 119
Cdd:COG2956   92 LDRAEELLE---KLLELDPDDAEALRLL 116
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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